内田 周作

最終更新日時: 2019/06/13 12:34:01

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氏名(漢字/フリガナ/アルファベット表記)
内田 周作/ウチダ シュウサク/Uchida, Shusaku
所属部署・職名(部局/所属/講座等/職名)
医学研究科/メディカルイノベーションセンター/特定准教授
取得学位
学位名(日本語) 学位名(英語) 大学(日本語) 大学(英語) 取得区分
修士(農芸化学) 東京農業大学
博士(農芸化学) 東京農業大学
researchmap URL
https://researchmap.jp/shusaku
研究テーマ
(日本語)
ストレス適応・不適応の脳内分子神経基盤
(英語)
Epigenetic mechanisms of stress-induced depression
研究概要
(日本語)
気分障害の発症には、生物学的要因や心理学的要因に加えてストレスなどの環境要因が関わると指摘されている。すなわち、うつ病患者はストレスに対して脆弱な生物学的素因を有しており、慢性的な環境ストレス暴露により神経可塑性異常を引き起こすことで発症に至る、といったストレス脆弱性仮説である。現在までに、脳画像・遺伝学・分子生物学的手法等を用いて、精神疾患発病脆弱性や危険因子に関わる遺伝・神経生物学的基盤の解析研究が精力的に行われている。一方、慢性ストレスに暴露された人すべてが精神疾患を発症するわけではなく、むしろ大多数の人はストレスに適応して精神的安定性を維持することができる。このようなストレスの影響に対する予防・緩衝要因としてのレジリエンスは、ストレッサーに暴露されても健康的な精神状態を維持する力(抵抗力)と、発病後に健康な状態へと導く力(回復力)、の二側面を持つ概念と捉えられている。しかしながら、従来の精神疾患の神経生物学的基盤研究は、もっぱら脆弱性や発病後の病態を想定したものであり、精神疾患の発症・病態・回復の機序をより深く理解するためには、レジリエンスの側面も取り入れた、一面的でない基盤研究が望まれる。我々は、ストレス脆弱性とレジリエンスの生物学的基盤を解明することでうつ病などのストレス関連精神疾患の発症・回復機序の理解をめざしている。
(英語)
Stressful events are potent adverse environmental factors that can predispose individuals to psychiatric disorders such as major depression. Exposure to chronic stress can be differently perceived by individuals and can have persistent sequelae depending on the level of stress resilience or vulnerability of each person. While stress vulnerability may influence depression, the molecular and neural mechanisms underlying the susceptibility and resilience to chronic stress within the brain are poorly understood. I focus on the role of epigenetic mechanisms in stress resilience and susceptibility in rodents.
研究分野(キーワード)
キーワード(日本語) キーワード(英語)
ストレス Stress
神経可塑性 Neural plasticity
遺伝子発現 Gene expression
エピジェネティクス Epigenetics
精神疾患 Psychiatric disorder
論文
著者 著者(日本語) 著者(英語) タイトル タイトル(日本語) タイトル(英語) 書誌情報等 書誌情報等(日本語) 書誌情報等(英語) 出版年月 査読の有無 記述言語 掲載種別 公開
Uchida S, Shumyatsky GP Uchida S, Shumyatsky GP Uchida S, Shumyatsky GP Synaptically Localized Transcriptional Regulators in Memory Formation. Synaptically Localized Transcriptional Regulators in Memory Formation. Synaptically Localized Transcriptional Regulators in Memory Formation. Neuroscience, 370, 4-13 Neuroscience, 370, 4-13 Neuroscience, 370, 4-13 2018/02 公開
Uchida S, Yamagata H, Seki T, Watanabe Y Uchida S, Yamagata H, Seki T, Watanabe Y Uchida S, Yamagata H, Seki T, Watanabe Y Epigenetic mechanisms of major depression: Targeting neuronal plasticity. Epigenetic mechanisms of major depression: Targeting neuronal plasticity. Epigenetic mechanisms of major depression: Targeting neuronal plasticity. Psychiatry and clinical neurosciences Psychiatry and clinical neurosciences Psychiatry and clinical neurosciences 2017/11 公開
Yamagata H, Uchida S, Matsuo K, Harada K, Kobayashi A, Nakashima M, Higuchi F, Watanuki T, Matsubara T, Watanabe Y Yamagata H, Uchida S, Matsuo K, Harada K, Kobayashi A, Nakashima M, Higuchi F, Watanuki T, Matsubara T, Watanabe Y Yamagata H, Uchida S, Matsuo K, Harada K, Kobayashi A, Nakashima M, Higuchi F, Watanuki T, Matsubara T, Watanabe Y Altered plasma protein glycosylation in a mouse model of depression and in patients with major depression. Altered plasma protein glycosylation in a mouse model of depression and in patients with major depression. Altered plasma protein glycosylation in a mouse model of depression and in patients with major depression. Journal of affective disorders Journal of affective disorders Journal of affective disorders 2017/08 公開
Yamagata H, Uchida S, Matsuo K, Harada K, Kobayashi A, Nakashima M, Nakano M, Otsuki K, Abe-Higuchi N, Higuchi F, Watanuki T, Matsubara T, Miyata S, Fukuda M, Mikuni M, Watanabe Y Yamagata H, Uchida S, Matsuo K, Harada K, Kobayashi A, Nakashima M, Nakano M, Otsuki K, Abe-Higuchi N, Higuchi F, Watanuki T, Matsubara T, Miyata S, Fukuda M, Mikuni M, Watanabe Y Yamagata H, Uchida S, Matsuo K, Harada K, Kobayashi A, Nakashima M, Nakano M, Otsuki K, Abe-Higuchi N, Higuchi F, Watanuki T, Matsubara T, Miyata S, Fukuda M, Mikuni M, Watanabe Y Identification of commonly altered genes between in major depressive disorder and a mouse model of depression. Identification of commonly altered genes between in major depressive disorder and a mouse model of depression. Identification of commonly altered genes between in major depressive disorder and a mouse model of depression. Scientific reports, 7, 1, 3044 Scientific reports, 7, 1, 3044 Scientific reports, 7, 1, 3044 2017/06 公開
Uchida S, Teubner BJ, Hevi C, Hara K, Kobayashi A, Dave RM, Shintaku T, Jaikhan P, Yamagata H, Suzuki T, Watanabe Y, Zakharenko SS, Shumyatsky GP Uchida S, Teubner BJ, Hevi C, Hara K, Kobayashi A, Dave RM, Shintaku T, Jaikhan P, Yamagata H, Suzuki T, Watanabe Y, Zakharenko SS, Shumyatsky GP Uchida S, Teubner BJ, Hevi C, Hara K, Kobayashi A, Dave RM, Shintaku T, Jaikhan P, Yamagata H, Suzuki T, Watanabe Y, Zakharenko SS, Shumyatsky GP CRTC1 Nuclear Translocation Following Learning Modulates Memory Strength via Exchange of Chromatin Remodeling Complexes on the Fgf1 Gene. CRTC1 Nuclear Translocation Following Learning Modulates Memory Strength via Exchange of Chromatin Remodeling Complexes on the Fgf1 Gene. CRTC1 Nuclear Translocation Following Learning Modulates Memory Strength via Exchange of Chromatin Remodeling Complexes on the Fgf1 Gene. Cell reports, 18, 2, 352-366 Cell reports, 18, 2, 352-366 Cell reports, 18, 2, 352-366 2017/01 公開
Abe-Higuchi N, Uchida S, Yamagata H, Higuchi F, Hobara T, Hara K, Kobayashi A, Watanabe Y Abe-Higuchi N, Uchida S, Yamagata H, Higuchi F, Hobara T, Hara K, Kobayashi A, Watanabe Y Abe-Higuchi N, Uchida S, Yamagata H, Higuchi F, Hobara T, Hara K, Kobayashi A, Watanabe Y Hippocampal Sirtuin 1 Signaling Mediates Depression-like Behavior. Hippocampal Sirtuin 1 Signaling Mediates Depression-like Behavior. Hippocampal Sirtuin 1 Signaling Mediates Depression-like Behavior. Biological psychiatry, 80, 11, 815-826 Biological psychiatry, 80, 11, 815-826 Biological psychiatry, 80, 11, 815-826 2016/12 公開
Higuchi F, Uchida S, Yamagata H, Abe-Higuchi N, Hobara T, Hara K, Kobayashi A, Shintaku T, Itoh Y, Suzuki T, Watanabe Y Higuchi F, Uchida S, Yamagata H, Abe-Higuchi N, Hobara T, Hara K, Kobayashi A, Shintaku T, Itoh Y, Suzuki T, Watanabe Y Higuchi F, Uchida S, Yamagata H, Abe-Higuchi N, Hobara T, Hara K, Kobayashi A, Shintaku T, Itoh Y, Suzuki T, Watanabe Y Hippocampal MicroRNA-124 Enhances Chronic Stress Resilience in Mice. Hippocampal MicroRNA-124 Enhances Chronic Stress Resilience in Mice. Hippocampal MicroRNA-124 Enhances Chronic Stress Resilience in Mice. The Journal of neuroscience : the official journal of the Society for Neuroscience, 36, 27, 7253-7267 The Journal of neuroscience : the official journal of the Society for Neuroscience, 36, 27, 7253-7267 The Journal of neuroscience : the official journal of the Society for Neuroscience, 36, 27, 7253-7267 2016/07 公開
Martel G, Uchida S, Hevi C, Chévere-Torres I, Fuentes I, Park YJ, Hafeez H, Yamagata H, Watanabe Y, Shumyatsky GP Martel G, Uchida S, Hevi C, Chévere-Torres I, Fuentes I, Park YJ, Hafeez H, Yamagata H, Watanabe Y, Shumyatsky GP Martel G, Uchida S, Hevi C, Chévere-Torres I, Fuentes I, Park YJ, Hafeez H, Yamagata H, Watanabe Y, Shumyatsky GP Genetic Demonstration of a Role for Stathmin in Adult Hippocampal Neurogenesis, Spinogenesis, and NMDA Receptor-Dependent Memory. Genetic Demonstration of a Role for Stathmin in Adult Hippocampal Neurogenesis, Spinogenesis, and NMDA Receptor-Dependent Memory. Genetic Demonstration of a Role for Stathmin in Adult Hippocampal Neurogenesis, Spinogenesis, and NMDA Receptor-Dependent Memory. The Journal of neuroscience : the official journal of the Society for Neuroscience, 36, 4, 1185-1202 The Journal of neuroscience : the official journal of the Society for Neuroscience, 36, 4, 1185-1202 The Journal of neuroscience : the official journal of the Society for Neuroscience, 36, 4, 1185-1202 2016/01 公開
Uchida S, Shumyatsky GP Uchida S, Shumyatsky GP Uchida S, Shumyatsky GP Deceivingly dynamic: Learning-dependent changes in stathmin and microtubules. Deceivingly dynamic: Learning-dependent changes in stathmin and microtubules. Deceivingly dynamic: Learning-dependent changes in stathmin and microtubules. Neurobiology of learning and memory, 124, 52-61 Neurobiology of learning and memory, 124, 52-61 Neurobiology of learning and memory, 124, 52-61 2015/10 公開
Uchida S, Martel G, Pavlowsky A, Takizawa S, Hevi C, Watanabe Y, Kandel ER, Alarcon JM, Shumyatsky GP Uchida S, Martel G, Pavlowsky A, Takizawa S, Hevi C, Watanabe Y, Kandel ER, Alarcon JM, Shumyatsky GP Uchida S, Martel G, Pavlowsky A, Takizawa S, Hevi C, Watanabe Y, Kandel ER, Alarcon JM, Shumyatsky GP Learning-induced and stathmin-dependent changes in microtubule stability are critical for memory and disrupted in ageing. Learning-induced and stathmin-dependent changes in microtubule stability are critical for memory and disrupted in ageing. Learning-induced and stathmin-dependent changes in microtubule stability are critical for memory and disrupted in ageing. Nature communications, 5, 4389 Nature communications, 5, 4389 Nature communications, 5, 4389 2014/07 公開
Shibata T, Yamagata H, Uchida S, Otsuki K, Hobara T, Higuchi F, Abe N, Watanabe Y Shibata T, Yamagata H, Uchida S, Otsuki K, Hobara T, Higuchi F, Abe N, Watanabe Y Shibata T, Yamagata H, Uchida S, Otsuki K, Hobara T, Higuchi F, Abe N, Watanabe Y The alteration of hypoxia inducible factor-1 (HIF-1) and its target genes in mood disorder patients. The alteration of hypoxia inducible factor-1 (HIF-1) and its target genes in mood disorder patients. The alteration of hypoxia inducible factor-1 (HIF-1) and its target genes in mood disorder patients. Progress in neuro-psychopharmacology & biological psychiatry, 43, 222-229 Progress in neuro-psychopharmacology & biological psychiatry, 43, 222-229 Progress in neuro-psychopharmacology & biological psychiatry, 43, 222-229 2013/06 公開
Otsuki K, Uchida S, Hobara T, Yamagata H, Watanabe Y Otsuki K, Uchida S, Hobara T, Yamagata H, Watanabe Y Otsuki K, Uchida S, Hobara T, Yamagata H, Watanabe Y [Epigenetic regulation in depression]. [Epigenetic regulation in depression]. [Epigenetic regulation in depression]. Nihon shinkei seishin yakurigaku zasshi = Japanese journal of psychopharmacology, 32, 4, 181-186 Nihon shinkei seishin yakurigaku zasshi = Japanese journal of psychopharmacology, 32, 4, 181-186 Nihon shinkei seishin yakurigaku zasshi = Japanese journal of psychopharmacology, 32, 4, 181-186 2012/08 公開
Nomoto M, Takeda Y, Uchida S, Mitsuda K, Enomoto H, Saito K, Choi T, Watabe AM, Kobayashi S, Masushige S, Manabe T, Kida S Nomoto M, Takeda Y, Uchida S, Mitsuda K, Enomoto H, Saito K, Choi T, Watabe AM, Kobayashi S, Masushige S, Manabe T, Kida S Nomoto M, Takeda Y, Uchida S, Mitsuda K, Enomoto H, Saito K, Choi T, Watabe AM, Kobayashi S, Masushige S, Manabe T, Kida S Dysfunction of the RAR/RXR signaling pathway in the forebrain impairs hippocampal memory and synaptic plasticity. Dysfunction of the RAR/RXR signaling pathway in the forebrain impairs hippocampal memory and synaptic plasticity. Dysfunction of the RAR/RXR signaling pathway in the forebrain impairs hippocampal memory and synaptic plasticity. Molecular brain, 5, 8 Molecular brain, 5, 8 Molecular brain, 5, 8 2012/02 公開
Martel G, Hevi C, Wong A, Zushida K, Uchida S, Shumyatsky GP Martel G, Hevi C, Wong A, Zushida K, Uchida S, Shumyatsky GP Martel G, Hevi C, Wong A, Zushida K, Uchida S, Shumyatsky GP Murine GRPR and stathmin control in opposite directions both cued fear extinction and neural activities of the amygdala and prefrontal cortex. Murine GRPR and stathmin control in opposite directions both cued fear extinction and neural activities of the amygdala and prefrontal cortex. Murine GRPR and stathmin control in opposite directions both cued fear extinction and neural activities of the amygdala and prefrontal cortex. PloS one, 7, 2, e30942 PloS one, 7, 2, e30942 PloS one, 7, 2, e30942 2012 公開
Watanabe Y, Uchida S, Otsuki K, Yamagata H, Hobara T, Abe N, Higuchi F, Watanuki T, Matsubara T Watanabe Y, Uchida S, Otsuki K, Yamagata H, Hobara T, Abe N, Higuchi F, Watanuki T, Matsubara T Watanabe Y, Uchida S, Otsuki K, Yamagata H, Hobara T, Abe N, Higuchi F, Watanuki T, Matsubara T [Functional biomarkers of mood disorders: differential diagnosis and clinical classification with gene expression in peripheral leukocytes]. [Functional biomarkers of mood disorders: differential diagnosis and clinical classification with gene expression in peripheral leukocytes]. [Functional biomarkers of mood disorders: differential diagnosis and clinical classification with gene expression in peripheral leukocytes]. Seishin shinkeigaku zasshi = Psychiatria et neurologia Japonica, 114, 7, 812-820 Seishin shinkeigaku zasshi = Psychiatria et neurologia Japonica, 114, 7, 812-820 Seishin shinkeigaku zasshi = Psychiatria et neurologia Japonica, 114, 7, 812-820 2012 公開
Higuchi F, Uchida S, Yamagata H, Otsuki K, Hobara T, Abe N, Shibata T, Watanabe Y Higuchi F, Uchida S, Yamagata H, Otsuki K, Hobara T, Abe N, Shibata T, Watanabe Y Higuchi F, Uchida S, Yamagata H, Otsuki K, Hobara T, Abe N, Shibata T, Watanabe Y State-dependent changes in the expression of DNA methyltransferases in mood disorder patients. State-dependent changes in the expression of DNA methyltransferases in mood disorder patients. State-dependent changes in the expression of DNA methyltransferases in mood disorder patients. Journal of psychiatric research, 45, 10, 1295-1300 Journal of psychiatric research, 45, 10, 1295-1300 Journal of psychiatric research, 45, 10, 1295-1300 2011/10 公開
Abe N, Uchida S, Otsuki K, Hobara T, Yamagata H, Higuchi F, Shibata T, Watanabe Y Abe N, Uchida S, Otsuki K, Hobara T, Yamagata H, Higuchi F, Shibata T, Watanabe Y Abe N, Uchida S, Otsuki K, Hobara T, Yamagata H, Higuchi F, Shibata T, Watanabe Y Altered sirtuin deacetylase gene expression in patients with a mood disorder. Altered sirtuin deacetylase gene expression in patients with a mood disorder. Altered sirtuin deacetylase gene expression in patients with a mood disorder. Journal of psychiatric research, 45, 8, 1106-1112 Journal of psychiatric research, 45, 8, 1106-1112 Journal of psychiatric research, 45, 8, 1106-1112 2011/08 公開
Hosoda H, Miyao T, Uchida S, Sakai S, Kida S Hosoda H, Miyao T, Uchida S, Sakai S, Kida S Hosoda H, Miyao T, Uchida S, Sakai S, Kida S Development of a tightly-regulated tetracycline-dependent transcriptional activator and repressor co-expression system for the strong induction of transgene expression. Development of a tightly-regulated tetracycline-dependent transcriptional activator and repressor co-expression system for the strong induction of transgene expression. Development of a tightly-regulated tetracycline-dependent transcriptional activator and repressor co-expression system for the strong induction of transgene expression. Cytotechnology, 63, 3, 211-216 Cytotechnology, 63, 3, 211-216 Cytotechnology, 63, 3, 211-216 2011/05 公開
Uchida S, Hara K, Kobayashi A, Otsuki K, Yamagata H, Hobara T, Suzuki T, Miyata N, Watanabe Y Uchida S, Hara K, Kobayashi A, Otsuki K, Yamagata H, Hobara T, Suzuki T, Miyata N, Watanabe Y Uchida S, Hara K, Kobayashi A, Otsuki K, Yamagata H, Hobara T, Suzuki T, Miyata N, Watanabe Y Epigenetic status of Gdnf in the ventral striatum determines susceptibility and adaptation to daily stressful events. Epigenetic status of Gdnf in the ventral striatum determines susceptibility and adaptation to daily stressful events. Epigenetic status of Gdnf in the ventral striatum determines susceptibility and adaptation to daily stressful events. Neuron, 69, 2, 359-372 Neuron, 69, 2, 359-372 Neuron, 69, 2, 359-372 2011/01 公開
Uchida S, Hara K, Kobayashi A, Fujimoto M, Otsuki K, Yamagata H, Hobara T, Abe N, Higuchi F, Shibata T, Hasegawa S, Kida S, Nakai A, Watanabe Y Uchida S, Hara K, Kobayashi A, Fujimoto M, Otsuki K, Yamagata H, Hobara T, Abe N, Higuchi F, Shibata T, Hasegawa S, Kida S, Nakai A, Watanabe Y Uchida S, Hara K, Kobayashi A, Fujimoto M, Otsuki K, Yamagata H, Hobara T, Abe N, Higuchi F, Shibata T, Hasegawa S, Kida S, Nakai A, Watanabe Y Impaired hippocampal spinogenesis and neurogenesis and altered affective behavior in mice lacking heat shock factor 1. Impaired hippocampal spinogenesis and neurogenesis and altered affective behavior in mice lacking heat shock factor 1. Impaired hippocampal spinogenesis and neurogenesis and altered affective behavior in mice lacking heat shock factor 1. Proceedings of the National Academy of Sciences of the United States of America, 108, 4, 1681-1686 Proceedings of the National Academy of Sciences of the United States of America, 108, 4, 1681-1686 Proceedings of the National Academy of Sciences of the United States of America, 108, 4, 1681-1686 2011/01 公開
Uchida S, Hara K, Kobayashi A, Funato H, Hobara T, Otsuki K, Yamagata H, McEwen BS, Watanabe Y Uchida S, Hara K, Kobayashi A, Funato H, Hobara T, Otsuki K, Yamagata H, McEwen BS, Watanabe Y Uchida S, Hara K, Kobayashi A, Funato H, Hobara T, Otsuki K, Yamagata H, McEwen BS, Watanabe Y Early life stress enhances behavioral vulnerability to stress through the activation of REST4-mediated gene transcription in the medial prefrontal cortex of rodents. Early life stress enhances behavioral vulnerability to stress through the activation of REST4-mediated gene transcription in the medial prefrontal cortex of rodents. Early life stress enhances behavioral vulnerability to stress through the activation of REST4-mediated gene transcription in the medial prefrontal cortex of rodents. The Journal of neuroscience : the official journal of the Society for Neuroscience, 30, 45, 15007-15018 The Journal of neuroscience : the official journal of the Society for Neuroscience, 30, 45, 15007-15018 The Journal of neuroscience : the official journal of the Society for Neuroscience, 30, 45, 15007-15018 2010/11 公開
Otsuki K, Uchida S, Wakabayashi Y, Matsubara T, Hobara T, Funato H, Watanabe Y Otsuki K, Uchida S, Wakabayashi Y, Matsubara T, Hobara T, Funato H, Watanabe Y Otsuki K, Uchida S, Wakabayashi Y, Matsubara T, Hobara T, Funato H, Watanabe Y Aberrant REST-mediated transcriptional regulation in major depressive disorder. Aberrant REST-mediated transcriptional regulation in major depressive disorder. Aberrant REST-mediated transcriptional regulation in major depressive disorder. Journal of psychiatric research, 44, 6, 378-384 Journal of psychiatric research, 44, 6, 378-384 Journal of psychiatric research, 44, 6, 378-384 2010/04 公開
Hobara T, Uchida S, Otsuki K, Matsubara T, Funato H, Matsuo K, Suetsugi M, Watanabe Y Hobara T, Uchida S, Otsuki K, Matsubara T, Funato H, Matsuo K, Suetsugi M, Watanabe Y Hobara T, Uchida S, Otsuki K, Matsubara T, Funato H, Matsuo K, Suetsugi M, Watanabe Y Altered gene expression of histone deacetylases in mood disorder patients. Altered gene expression of histone deacetylases in mood disorder patients. Altered gene expression of histone deacetylases in mood disorder patients. Journal of psychiatric research, 44, 5, 263-270 Journal of psychiatric research, 44, 5, 263-270 Journal of psychiatric research, 44, 5, 263-270 2010/04 公開
Uchida S, Hara K, Kobayashi A, Otsuki K, Hobara T, Yamagata H, Watanabe Y Uchida S, Hara K, Kobayashi A, Otsuki K, Hobara T, Yamagata H, Watanabe Y Uchida S, Hara K, Kobayashi A, Otsuki K, Hobara T, Yamagata H, Watanabe Y Maternal and genetic factors in stress-resilient and -vulnerable rats: a cross-fostering study. Maternal and genetic factors in stress-resilient and -vulnerable rats: a cross-fostering study. Maternal and genetic factors in stress-resilient and -vulnerable rats: a cross-fostering study. Brain research, 1316, 43-50 Brain research, 1316, 43-50 Brain research, 1316, 43-50 2010/02 公開
Otsuki K, Uchida S, Watanuki T, Wakabayashi Y, Fujimoto M, Matsubara T, Funato H, Watanabe Y Otsuki K, Uchida S, Watanuki T, Wakabayashi Y, Fujimoto M, Matsubara T, Funato H, Watanabe Y Otsuki K, Uchida S, Watanuki T, Wakabayashi Y, Fujimoto M, Matsubara T, Funato H, Watanabe Y Altered expression of neurotrophic factors in patients with major depression. Altered expression of neurotrophic factors in patients with major depression. Altered expression of neurotrophic factors in patients with major depression. Journal of psychiatric research, 42, 14, 1145-1153 Journal of psychiatric research, 42, 14, 1145-1153 Journal of psychiatric research, 42, 14, 1145-1153 2008/10 公開
Watanuki T, Funato H, Uchida S, Matsubara T, Kobayashi A, Wakabayashi Y, Otsuki K, Nishida A, Watanabe Y Watanuki T, Funato H, Uchida S, Matsubara T, Kobayashi A, Wakabayashi Y, Otsuki K, Nishida A, Watanabe Y Watanuki T, Funato H, Uchida S, Matsubara T, Kobayashi A, Wakabayashi Y, Otsuki K, Nishida A, Watanabe Y Increased expression of splicing factor SRp20 mRNA in bipolar disorder patients. Increased expression of splicing factor SRp20 mRNA in bipolar disorder patients. Increased expression of splicing factor SRp20 mRNA in bipolar disorder patients. Journal of affective disorders, 110, 1-2, 62-69 Journal of affective disorders, 110, 1-2, 62-69 Journal of affective disorders, 110, 1-2, 62-69 2008/09 公開
Wakabayashi Y, Uchida S, Funato H, Matsubara T, Watanuki T, Otsuki K, Fujimoto M, Nishida A, Watanabe Y Wakabayashi Y, Uchida S, Funato H, Matsubara T, Watanuki T, Otsuki K, Fujimoto M, Nishida A, Watanabe Y Wakabayashi Y, Uchida S, Funato H, Matsubara T, Watanuki T, Otsuki K, Fujimoto M, Nishida A, Watanabe Y State-dependent changes in the expression levels of NCAM-140 and L1 in the peripheral blood cells of bipolar disorders, but not in the major depressive disorders. State-dependent changes in the expression levels of NCAM-140 and L1 in the peripheral blood cells of bipolar disorders, but not in the major depressive disorders. State-dependent changes in the expression levels of NCAM-140 and L1 in the peripheral blood cells of bipolar disorders, but not in the major depressive disorders. Progress in neuro-psychopharmacology & biological psychiatry, 32, 5, 1199-1205 Progress in neuro-psychopharmacology & biological psychiatry, 32, 5, 1199-1205 Progress in neuro-psychopharmacology & biological psychiatry, 32, 5, 1199-1205 2008/07 公開
Fujimoto M, Uchida S, Watanuki T, Wakabayashi Y, Otsuki K, Matsubara T, Suetsugi M, Funato H, Watanabe Y Fujimoto M, Uchida S, Watanuki T, Wakabayashi Y, Otsuki K, Matsubara T, Suetsugi M, Funato H, Watanabe Y Fujimoto M, Uchida S, Watanuki T, Wakabayashi Y, Otsuki K, Matsubara T, Suetsugi M, Funato H, Watanabe Y Reduced expression of glyoxalase-1 mRNA in mood disorder patients. Reduced expression of glyoxalase-1 mRNA in mood disorder patients. Reduced expression of glyoxalase-1 mRNA in mood disorder patients. Neuroscience letters, 438, 2, 196-199 Neuroscience letters, 438, 2, 196-199 Neuroscience letters, 438, 2, 196-199 2008/06 公開
Uchida S, Nishida A, Hara K, Kamemoto T, Suetsugi M, Fujimoto M, Watanuki T, Wakabayashi Y, Otsuki K, McEwen BS, Watanabe Y Uchida S, Nishida A, Hara K, Kamemoto T, Suetsugi M, Fujimoto M, Watanuki T, Wakabayashi Y, Otsuki K, McEwen BS, Watanabe Y Uchida S, Nishida A, Hara K, Kamemoto T, Suetsugi M, Fujimoto M, Watanuki T, Wakabayashi Y, Otsuki K, McEwen BS, Watanabe Y Characterization of the vulnerability to repeated stress in Fischer 344 rats: possible involvement of microRNA-mediated down-regulation of the glucocorticoid receptor. Characterization of the vulnerability to repeated stress in Fischer 344 rats: possible involvement of microRNA-mediated down-regulation of the glucocorticoid receptor. Characterization of the vulnerability to repeated stress in Fischer 344 rats: possible involvement of microRNA-mediated down-regulation of the glucocorticoid receptor. The European journal of neuroscience, 27, 9, 2250-2261 The European journal of neuroscience, 27, 9, 2250-2261 The European journal of neuroscience, 27, 9, 2250-2261 2008/05 公開
Uchida S, Umeeda H, Kitamoto A, Masushige S, Kida S Uchida S, Umeeda H, Kitamoto A, Masushige S, Kida S Uchida S, Umeeda H, Kitamoto A, Masushige S, Kida S Chronic reduction in dietary tryptophan leads to a selective impairment of contextual fear memory in mice. Chronic reduction in dietary tryptophan leads to a selective impairment of contextual fear memory in mice. Chronic reduction in dietary tryptophan leads to a selective impairment of contextual fear memory in mice. Brain research, 1149, 149-156 Brain research, 1149, 149-156 Brain research, 1149, 149-156 2007/05 公開
Suetsugi M, Mizuki Y, Yamamoto K, Uchida S, Watanabe Y Suetsugi M, Mizuki Y, Yamamoto K, Uchida S, Watanabe Y Suetsugi M, Mizuki Y, Yamamoto K, Uchida S, Watanabe Y The effect of placebo administration on the first-night effect in healthy young volunteers. The effect of placebo administration on the first-night effect in healthy young volunteers. The effect of placebo administration on the first-night effect in healthy young volunteers. Progress in neuro-psychopharmacology & biological psychiatry, 31, 4, 839-847 Progress in neuro-psychopharmacology & biological psychiatry, 31, 4, 839-847 Progress in neuro-psychopharmacology & biological psychiatry, 31, 4, 839-847 2007/05 公開
Uchida S, Sakai S, Furuichi T, Hosoda H, Toyota K, Ishii T, Kitamoto A, Sekine M, Koike K, Masushige S, Murphy G, Silva AJ, Kida S Uchida S, Sakai S, Furuichi T, Hosoda H, Toyota K, Ishii T, Kitamoto A, Sekine M, Koike K, Masushige S, Murphy G, Silva AJ, Kida S Uchida S, Sakai S, Furuichi T, Hosoda H, Toyota K, Ishii T, Kitamoto A, Sekine M, Koike K, Masushige S, Murphy G, Silva AJ, Kida S Tight regulation of transgene expression by tetracycline-dependent activator and repressor in brain. Tight regulation of transgene expression by tetracycline-dependent activator and repressor in brain. Tight regulation of transgene expression by tetracycline-dependent activator and repressor in brain. Genes, brain, and behavior, 5, 96-106 Genes, brain, and behavior, 5, 96-106 Genes, brain, and behavior, 5, 96-106 2006/02 公開
Uchida S, Kitamoto A, Umeeda H, Nakagawa N, Masushige S, Kida S Uchida S, Kitamoto A, Umeeda H, Nakagawa N, Masushige S, Kida S Uchida S, Kitamoto A, Umeeda H, Nakagawa N, Masushige S, Kida S Chronic reduction in dietary tryptophan leads to changes in the emotional response to stress in mice. Chronic reduction in dietary tryptophan leads to changes in the emotional response to stress in mice. Chronic reduction in dietary tryptophan leads to changes in the emotional response to stress in mice. Journal of nutritional science and vitaminology, 51, 3, 175-181 Journal of nutritional science and vitaminology, 51, 3, 175-181 Journal of nutritional science and vitaminology, 51, 3, 175-181 2005/06 公開
Kida S, Uchida S Kida S, Uchida S Kida S, Uchida S [Regulation of emotional behavior by nuclear receptors]. [Regulation of emotional behavior by nuclear receptors]. [Regulation of emotional behavior by nuclear receptors]. Nihon yakurigaku zasshi. Folia pharmacologica Japonica, 125, 1, 17-24 Nihon yakurigaku zasshi. Folia pharmacologica Japonica, 125, 1, 17-24 Nihon yakurigaku zasshi. Folia pharmacologica Japonica, 125, 1, 17-24 2005/01 公開

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タイトル言語:
外部資金:競争的資金・科学研究費補助金
種別 代表/分担 テーマ(日本語) テーマ(英語) 期間
基盤研究(B) 代表 うつ病発症脆弱性の個体差・性差構築に関わる分子神経基盤の解明 (平成30年度分) 2018/04/01〜2019/03/31