ＷＯＬＴＪＥＮ ＫＮＵＴ

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氏名(漢字／フリガナ／アルファベット表記)
ＷＯＬＴＪＥＮ ＫＮＵＴ／ウォルツェン クヌート／Woltjen, Knut
所属部署・職名(部局／所属／講座等／職名)
ｉＰＳ細胞研究所／未来生命科学開拓部門／准教授
連絡先住所
種別 住所(日本語) 住所(英語)
職場 〒606-8507 京都市 左京区 聖護院川原町５３ 日本 53 Kawahara-cho, Shogoin, Sakyo-ku Kyoto 〒606-8507 Japan
連絡先電話番号
種別 番号
職場 075-366-7000
取得学位
学位名(日本語) 学位名(英語) 大学(日本語) 大学(英語) 取得区分
Ph.D. University of Calgary
使用言語
言語名
English
Japanese
個人ホームページ
URL
http://www.cira.kyoto-u.ac.jp/woltjen/
researchmap URL
https://researchmap.jp/7000008096
研究分野（キーワード）
キーワード(日本語) キーワード(英語)
DNA recombination, stem cell biology, regenerative medicine, genomics
論文
著者 著者(日本語) 著者(英語) タイトル タイトル(日本語) タイトル(英語) 書誌情報等 書誌情報等(日本語) 書誌情報等(英語) 出版年月 査読の有無 記述言語 掲載種別 公開
Yagi M, Kabata M, Ukai T, Ohta S, Tanaka A, Shimada Y, Sugimoto M, Araki K, Okita K, Woltjen K, Hochedlinger K, Yamamoto T, Yamada Y Yagi M, Kabata M, Ukai T, Ohta S, Tanaka A, Shimada Y, Sugimoto M, Araki K, Okita K, Woltjen K, Hochedlinger K, Yamamoto T, Yamada Y Yagi M, Kabata M, Ukai T, Ohta S, Tanaka A, Shimada Y, Sugimoto M, Araki K, Okita K, Woltjen K, Hochedlinger K, Yamamoto T, Yamada Y De Novo DNA Methylation at Imprinted Loci during Reprogramming into Naive and Primed Pluripotency. De Novo DNA Methylation at Imprinted Loci during Reprogramming into Naive and Primed Pluripotency. De Novo DNA Methylation at Imprinted Loci during Reprogramming into Naive and Primed Pluripotency. Stem cell reports, 12, 5, 1113-1128 Stem cell reports, 12, 5, 1113-1128 Stem cell reports, 12, 5, 1113-1128 2019/05 有 公開
Jo N, Sogabe Y, Yamada Y, Ukai T, Kagawa H, Mitsunaga K, Woltjen K, Yamada Y Jo N, Sogabe Y, Yamada Y, Ukai T, Kagawa H, Mitsunaga K, Woltjen K, Yamada Y Jo N, Sogabe Y, Yamada Y, Ukai T, Kagawa H, Mitsunaga K, Woltjen K, Yamada Y Platforms of in vivo genome editing with inducible Cas9 for advanced cancer modeling. Platforms of in vivo genome editing with inducible Cas9 for advanced cancer modeling. Platforms of in vivo genome editing with inducible Cas9 for advanced cancer modeling. Cancer science, 110, 3, 926-938 Cancer science, 110, 3, 926-938 Cancer science, 110, 3, 926-938 2019/03 有 公開
Kagawa H, Shimamoto R, Kim SI, Oceguera-Yanez F, Yamamoto T, Schroeder T, Woltjen K Kagawa H, Shimamoto R, Kim SI, Oceguera-Yanez F, Yamamoto T, Schroeder T, Woltjen K Kagawa H, Shimamoto R, Kim SI, Oceguera-Yanez F, Yamamoto T, Schroeder T, Woltjen K OVOL1 Influences the Determination and Expansion of iPSC Reprogramming Intermediates. OVOL1 Influences the Determination and Expansion of iPSC Reprogramming Intermediates. OVOL1 Influences the Determination and Expansion of iPSC Reprogramming Intermediates. Stem cell reports, 12, 2, 319-332 Stem cell reports, 12, 2, 319-332 Stem cell reports, 12, 2, 319-332 2019/02 有 公開
Woltjen K, Bortvin A Woltjen K, Bortvin A Woltjen K, Bortvin A Editorial overview: Embroidering the canvas of life. Editorial overview: Embroidering the canvas of life. Editorial overview: Embroidering the canvas of life. Current opinion in genetics & development, 52, ii-iv Current opinion in genetics & development, 52, ii-iv Current opinion in genetics & development, 52, ii-iv 2018/10 有 公開
Shibata H, Komura S, Yamada Y, Sankoda N, Tanaka A, Ukai T, Kabata M, Sakurai S, Kuze B, Woltjen K, Haga H, Ito Y, Kawaguchi Y, Yamamoto T, Yamada Y Shibata H, Komura S, Yamada Y, Sankoda N, Tanaka A, Ukai T, Kabata M, Sakurai S, Kuze B, Woltjen K, Haga H, Ito Y, Kawaguchi Y, Yamamoto T, Yamada Y Shibata H, Komura S, Yamada Y, Sankoda N, Tanaka A, Ukai T, Kabata M, Sakurai S, Kuze B, Woltjen K, Haga H, Ito Y, Kawaguchi Y, Yamamoto T, Yamada Y In vivo reprogramming drives Kras-induced cancer development. In vivo reprogramming drives Kras-induced cancer development. In vivo reprogramming drives Kras-induced cancer development. Nature communications, 9, 1, 2081 Nature communications, 9, 1, 2081 Nature communications, 9, 1, 2081 2018/05 有 公開
Ikeda T, Hikichi T, Miura H, Shibata H, Mitsunaga K, Yamada Y, Woltjen K, Miyamoto K, Hiratani I, Yamada Y, Hotta A, Yamamoto T, Okita K, Masui S Ikeda T, Hikichi T, Miura H, Shibata H, Mitsunaga K, Yamada Y, Woltjen K, Miyamoto K, Hiratani I, Yamada Y, Hotta A, Yamamoto T, Okita K, Masui S Ikeda T, Hikichi T, Miura H, Shibata H, Mitsunaga K, Yamada Y, Woltjen K, Miyamoto K, Hiratani I, Yamada Y, Hotta A, Yamamoto T, Okita K, Masui S Srf destabilizes cellular identity by suppressing cell-type-specific gene expression programs. Srf destabilizes cellular identity by suppressing cell-type-specific gene expression programs. Srf destabilizes cellular identity by suppressing cell-type-specific gene expression programs. Nature communications, 9, 1, 1387 Nature communications, 9, 1, 1387 Nature communications, 9, 1, 1387 2018/04 有 公開
Kim SI, Matsumoto T, Kagawa H, Nakamura M, Hirohata R, Ueno A, Ohishi M, Sakuma T, Soga T, Yamamoto T, Woltjen K Kim SI, Matsumoto T, Kagawa H, Nakamura M, Hirohata R, Ueno A, Ohishi M, Sakuma T, Soga T, Yamamoto T, Woltjen K Kim SI, Matsumoto T, Kagawa H, Nakamura M, Hirohata R, Ueno A, Ohishi M, Sakuma T, Soga T, Yamamoto T, Woltjen K Microhomology-assisted scarless genome editing in human iPSCs. Microhomology-assisted scarless genome editing in human iPSCs. Microhomology-assisted scarless genome editing in human iPSCs. Nature communications, 9, 1, 939 Nature communications, 9, 1, 939 Nature communications, 9, 1, 939 2018/03 有 公開
Kondo T, Imamura K, Funayama M, Tsukita K, Miyake M, Ohta A, Woltjen K, Nakagawa M, Asada T, Arai T, Kawakatsu S, Izumi Y, Kaji R, Iwata N, Inoue H Kondo T, Imamura K, Funayama M, Tsukita K, Miyake M, Ohta A, Woltjen K, Nakagawa M, Asada T, Arai T, Kawakatsu S, Izumi Y, Kaji R, Iwata N, Inoue H Kondo T, Imamura K, Funayama M, Tsukita K, Miyake M, Ohta A, Woltjen K, Nakagawa M, Asada T, Arai T, Kawakatsu S, Izumi Y, Kaji R, Iwata N, Inoue H iPSC-Based Compound Screening and In Vitro Trials Identify a Synergistic Anti-amyloid β Combination for Alzheimer's Disease. iPSC-Based Compound Screening and In Vitro Trials Identify a Synergistic Anti-amyloid β Combination for Alzheimer's Disease. iPSC-Based Compound Screening and In Vitro Trials Identify a Synergistic Anti-amyloid β Combination for Alzheimer's Disease. Cell reports, 21, 8, 2304-2312 Cell reports, 21, 8, 2304-2312 Cell reports, 21, 8, 2304-2312 2017/11 有 公開
Kojima Y, Sasaki K, Yokobayashi S, Sakai Y, Nakamura T, Yabuta Y, Nakaki F, Nagaoka S, Woltjen K, Hotta A, Yamamoto T, Saitou M Kojima Y, Sasaki K, Yokobayashi S, Sakai Y, Nakamura T, Yabuta Y, Nakaki F, Nagaoka S, Woltjen K, Hotta A, Yamamoto T, Saitou M Kojima Y, Sasaki K, Yokobayashi S, Sakai Y, Nakamura T, Yabuta Y, Nakaki F, Nagaoka S, Woltjen K, Hotta A, Yamamoto T, Saitou M Evolutionarily Distinctive Transcriptional and Signaling Programs Drive Human Germ Cell Lineage Specification from Pluripotent Stem Cells. Evolutionarily Distinctive Transcriptional and Signaling Programs Drive Human Germ Cell Lineage Specification from Pluripotent Stem Cells. Evolutionarily Distinctive Transcriptional and Signaling Programs Drive Human Germ Cell Lineage Specification from Pluripotent Stem Cells. Cell stem cell, 21, 4, 517-532.e5 Cell stem cell, 21, 4, 517-532.e5 Cell stem cell, 21, 4, 517-532.e5 2017/10 有 公開
Kieffer TJ, Woltjen K, Osafune K, Yabe D, Inagaki N Kieffer TJ, Woltjen K, Osafune K, Yabe D, Inagaki N Kieffer TJ, Woltjen K, Osafune K, Yabe D, Inagaki N Beta-cell replacement strategies for diabetes. Beta-cell replacement strategies for diabetes. Beta-cell replacement strategies for diabetes. Journal of diabetes investigation Journal of diabetes investigation Journal of diabetes investigation 2017/10 有 公開
Hirosawa M, Fujita Y, Parr CJC, Hayashi K, Kashida S, Hotta A, Woltjen K, Saito H Hirosawa M, Fujita Y, Parr CJC, Hayashi K, Kashida S, Hotta A, Woltjen K, Saito H Hirosawa M, Fujita Y, Parr CJC, Hayashi K, Kashida S, Hotta A, Woltjen K, Saito H Cell-type-specific genome editing with a microRNA-responsive CRISPR-Cas9 switch. Cell-type-specific genome editing with a microRNA-responsive CRISPR-Cas9 switch. Cell-type-specific genome editing with a microRNA-responsive CRISPR-Cas9 switch. Nucleic acids research, 45, 13, e118 Nucleic acids research, 45, 13, e118 Nucleic acids research, 45, 13, e118 2017/07 有 公開
Imamura K, Izumi Y, Watanabe A, Tsukita K, Woltjen K, Yamamoto T, Hotta A, Kondo T, Kitaoka S, Ohta A, Tanaka A, Watanabe D, Morita M, Takuma H, Tamaoka A, Kunath T, Wray S, Furuya H, Era T, Makioka K, Okamoto K, Fujisawa T, Nishitoh H, Homma K, Ichijo H, Julien JP, Obata N, Hosokawa M, Akiyama H, Kaneko S, Ayaki T, Ito H, Kaji R, Takahashi R, Yamanaka S, Inoue H Imamura K, Izumi Y, Watanabe A, Tsukita K, Woltjen K, Yamamoto T, Hotta A, Kondo T, Kitaoka S, Ohta A, Tanaka A, Watanabe D, Morita M, Takuma H, Tamaoka A, Kunath T, Wray S, Furuya H, Era T, Makioka K, Okamoto K, Fujisawa T, Nishitoh H, Homma K, Ichijo H, Julien JP, Obata N, Hosokawa M, Akiyama H, Kaneko S, Ayaki T, Ito H, Kaji R, Takahashi R, Yamanaka S, Inoue H Imamura K, Izumi Y, Watanabe A, Tsukita K, Woltjen K, Yamamoto T, Hotta A, Kondo T, Kitaoka S, Ohta A, Tanaka A, Watanabe D, Morita M, Takuma H, Tamaoka A, Kunath T, Wray S, Furuya H, Era T, Makioka K, Okamoto K, Fujisawa T, Nishitoh H, Homma K, Ichijo H, Julien JP, Obata N, Hosokawa M, Akiyama H, Kaneko S, Ayaki T, Ito H, Kaji R, Takahashi R, Yamanaka S, Inoue H The Src/c-Abl pathway is a potential therapeutic target in amyotrophic lateral sclerosis. The Src/c-Abl pathway is a potential therapeutic target in amyotrophic lateral sclerosis. The Src/c-Abl pathway is a potential therapeutic target in amyotrophic lateral sclerosis. Science translational medicine, 9, 391 Science translational medicine, 9, 391 Science translational medicine, 9, 391 2017/05 有 公開
Sone M, Morone N, Nakamura T, Tanaka A, Okita K, Woltjen K, Nakagawa M, Heuser JE, Yamada Y, Yamanaka S, Yamamoto T Sone M, Morone N, Nakamura T, Tanaka A, Okita K, Woltjen K, Nakagawa M, Heuser JE, Yamada Y, Yamanaka S, Yamamoto T Sone M, Morone N, Nakamura T, Tanaka A, Okita K, Woltjen K, Nakagawa M, Heuser JE, Yamada Y, Yamanaka S, Yamamoto T Hybrid Cellular Metabolism Coordinated by Zic3 and Esrrb Synergistically Enhances Induction of Naive Pluripotency. Hybrid Cellular Metabolism Coordinated by Zic3 and Esrrb Synergistically Enhances Induction of Naive Pluripotency. Hybrid Cellular Metabolism Coordinated by Zic3 and Esrrb Synergistically Enhances Induction of Naive Pluripotency. Cell metabolism, 25, 5, 1103-1117.e6 Cell metabolism, 25, 5, 1103-1117.e6 Cell metabolism, 25, 5, 1103-1117.e6 2017/05 有 公開
Hashimoto K, Yamada Y, Semi K, Yagi M, Tanaka A, Itakura F, Aoki H, Kunisada T, Woltjen K, Haga H, Sakai Y, Yamamoto T, Yamada Y Hashimoto K, Yamada Y, Semi K, Yagi M, Tanaka A, Itakura F, Aoki H, Kunisada T, Woltjen K, Haga H, Sakai Y, Yamamoto T, Yamada Y Hashimoto K, Yamada Y, Semi K, Yagi M, Tanaka A, Itakura F, Aoki H, Kunisada T, Woltjen K, Haga H, Sakai Y, Yamamoto T, Yamada Y Cellular context-dependent consequences of Apc mutations on gene regulation and cellular behavior. Cellular context-dependent consequences of Apc mutations on gene regulation and cellular behavior. Cellular context-dependent consequences of Apc mutations on gene regulation and cellular behavior. Proceedings of the National Academy of Sciences of the United States of America, 114, 4, 758-763 Proceedings of the National Academy of Sciences of the United States of America, 114, 4, 758-763 Proceedings of the National Academy of Sciences of the United States of America, 114, 4, 758-763 2017/01 有 公開
Woltjen K, Yamamoto T, Kokubu C, Takeda J Woltjen K, Yamamoto T, Kokubu C, Takeda J Woltjen K, Yamamoto T, Kokubu C, Takeda J Report on the Conference on Transposition and Genome Engineering 2015 (TGE 2015): advancing cutting-edge genomics technology in the ancient city of Nara. Report on the Conference on Transposition and Genome Engineering 2015 (TGE 2015): advancing cutting-edge genomics technology in the ancient city of Nara. Report on the Conference on Transposition and Genome Engineering 2015 (TGE 2015): advancing cutting-edge genomics technology in the ancient city of Nara. Genes to cells : devoted to molecular & cellular mechanisms, 21, 5, 392-395 Genes to cells : devoted to molecular & cellular mechanisms, 21, 5, 392-395 Genes to cells : devoted to molecular & cellular mechanisms, 21, 5, 392-395 2016/05 有 公開
Oceguera-Yanez F, Kim SI, Matsumoto T, Tan GW, Xiang L, Hatani T, Kondo T, Ikeya M, Yoshida Y, Inoue H, Woltjen K Oceguera-Yanez F, Kim SI, Matsumoto T, Tan GW, Xiang L, Hatani T, Kondo T, Ikeya M, Yoshida Y, Inoue H, Woltjen K Oceguera-Yanez F, Kim SI, Matsumoto T, Tan GW, Xiang L, Hatani T, Kondo T, Ikeya M, Yoshida Y, Inoue H, Woltjen K Engineering the AAVS1 locus for consistent and scalable transgene expression in human iPSCs and their differentiated derivatives. Engineering the AAVS1 locus for consistent and scalable transgene expression in human iPSCs and their differentiated derivatives. Engineering the AAVS1 locus for consistent and scalable transgene expression in human iPSCs and their differentiated derivatives. Methods (San Diego, Calif.), 101, 43-55 Methods (San Diego, Calif.), 101, 43-55 Methods (San Diego, Calif.), 101, 43-55 2016/05 有 公開
Komura S, Semi K, Itakura F, Shibata H, Ohno T, Hotta A, Woltjen K, Yamamoto T, Akiyama H, Yamada Y Komura S, Semi K, Itakura F, Shibata H, Ohno T, Hotta A, Woltjen K, Yamamoto T, Akiyama H, Yamada Y Komura S, Semi K, Itakura F, Shibata H, Ohno T, Hotta A, Woltjen K, Yamamoto T, Akiyama H, Yamada Y An EWS-FLI1-Induced Osteosarcoma Model Unveiled a Crucial Role of Impaired Osteogenic Differentiation on Osteosarcoma Development. An EWS-FLI1-Induced Osteosarcoma Model Unveiled a Crucial Role of Impaired Osteogenic Differentiation on Osteosarcoma Development. An EWS-FLI1-Induced Osteosarcoma Model Unveiled a Crucial Role of Impaired Osteogenic Differentiation on Osteosarcoma Development. Stem cell reports, 6, 4, 592-606 Stem cell reports, 6, 4, 592-606 Stem cell reports, 6, 4, 592-606 2016/04 有 公開
Woltjen K, Kim SI, Nagy A Woltjen K, Kim SI, Nagy A Woltjen K, Kim SI, Nagy A The piggyBac Transposon as a Platform Technology for Somatic Cell Reprogramming Studies in Mouse. The piggyBac Transposon as a Platform Technology for Somatic Cell Reprogramming Studies in Mouse. The piggyBac Transposon as a Platform Technology for Somatic Cell Reprogramming Studies in Mouse. Methods in molecular biology (Clifton, N.J.), 1357, 1-22 Methods in molecular biology (Clifton, N.J.), 1357, 1-22 Methods in molecular biology (Clifton, N.J.), 1357, 1-22 2016 有 公開
Chantzoura E, Skylaki S, Menendez S, Kim SI, Johnsson A, Linnarsson S, Woltjen K, Chambers I, Kaji K Chantzoura E, Skylaki S, Menendez S, Kim SI, Johnsson A, Linnarsson S, Woltjen K, Chambers I, Kaji K Chantzoura E, Skylaki S, Menendez S, Kim SI, Johnsson A, Linnarsson S, Woltjen K, Chambers I, Kaji K Reprogramming Roadblocks Are System Dependent. Reprogramming Roadblocks Are System Dependent. Reprogramming Roadblocks Are System Dependent. Stem cell reports, 5, 3, 350-364 Stem cell reports, 5, 3, 350-364 Stem cell reports, 5, 3, 350-364 2015/09 有 公開
Sasaki K, Yokobayashi S, Nakamura T, Okamoto I, Yabuta Y, Kurimoto K, Ohta H, Moritoki Y, Iwatani C, Tsuchiya H, Nakamura S, Sekiguchi K, Sakuma T, Yamamoto T, Mori T, Woltjen K, Nakagawa M, Yamamoto T, Takahashi K, Yamanaka S, Saitou M Sasaki K, Yokobayashi S, Nakamura T, Okamoto I, Yabuta Y, Kurimoto K, Ohta H, Moritoki Y, Iwatani C, Tsuchiya H, Nakamura S, Sekiguchi K, Sakuma T, Yamamoto T, Mori T, Woltjen K, Nakagawa M, Yamamoto T, Takahashi K, Yamanaka S, Saitou M Sasaki K, Yokobayashi S, Nakamura T, Okamoto I, Yabuta Y, Kurimoto K, Ohta H, Moritoki Y, Iwatani C, Tsuchiya H, Nakamura S, Sekiguchi K, Sakuma T, Yamamoto T, Mori T, Woltjen K, Nakagawa M, Yamamoto T, Takahashi K, Yamanaka S, Saitou M Robust In Vitro Induction of Human Germ Cell Fate from Pluripotent Stem Cells. Robust In Vitro Induction of Human Germ Cell Fate from Pluripotent Stem Cells. Robust In Vitro Induction of Human Germ Cell Fate from Pluripotent Stem Cells. Cell stem cell, 17, 2, 178-194 Cell stem cell, 17, 2, 178-194 Cell stem cell, 17, 2, 178-194 2015/08 有 公開
WOLTJEN KNUT WOLTJEN KNUT Kim SI, Oceguera-Yanez F, Hirohata R, Linker S, Okita K, Yamada Y, Yamamoto T, Yamanaka S, Woltjen K. KLF4 N-terminal variance modulates induced reprogramming to pluripotency. KLF4 N-terminal variance modulates induced reprogramming to pluripotency. KLF4 N-terminal variance modulates induced reprogramming to pluripotency. Stem Cell Reports, 4, 4, 727-743 Stem Cell Reports, 4, 4, 727-743 Stem Cell Reports, 4, 4, 727-743 2015/04 有 英語 研究論文(学術雑誌) 公開
WOLTJEN KNUT WOLTJEN KNUT Matsuda M, Koga M, Woltjen K, Nishida E, Ebisuya M. Synthetic lateral inhibition governs cell-type bifurcation with robust ratios. Synthetic lateral inhibition governs cell-type bifurcation with robust ratios. Synthetic lateral inhibition governs cell-type bifurcation with robust ratios. Nature Communications, 6, 6195 Nature Communications, 6, 6195 Nature Communications, 6, 6195 2015 有 英語 研究論文(学術雑誌) 公開
WOLTJEN KNUT WOLTJEN KNUT Shoji E, Woltjen K, Sakurai H. Directed Myogenic Differentiation of Human Induced Pluripotent Stem Cells. Directed Myogenic Differentiation of Human Induced Pluripotent Stem Cells. Directed Myogenic Differentiation of Human Induced Pluripotent Stem Cells. Methods in Molecular Biology, 1353, 89-99 Methods in Molecular Biology, 1353, 89-99 Methods in Molecular Biology, 1353, 89-99 2015 有 英語 研究論文(学術雑誌) 公開
WOLTJEN KNUT WOLTJEN KNUT Kim SI, Oceguera-Yanez F, Sakurai C, Nakagawa M, Yamanaka S, Woltjen K Inducible Transgene Expression in Human iPS Cells Using Versatile All-in-One piggyBac Transposons. Inducible Transgene Expression in Human iPS Cells Using Versatile All-in-One piggyBac Transposons. Inducible Transgene Expression in Human iPS Cells Using Versatile All-in-One piggyBac Transposons. Methods in Molecular Biology, 1357, 111-131 Methods in Molecular Biology, 1357, 111-131 Methods in Molecular Biology, 1357, 111-131 2015 有 英語 研究論文(学術雑誌) 公開
Tamaki S, Fukuta M, Sekiguchi K, Jin Y, Nagata S, Hayakawa K, Hineno S, Okamoto T, Watanabe M, Woltjen K, Ikeya M, Kato T Jr, Toguchida J Tamaki S, Fukuta M, Sekiguchi K, Jin Y, Nagata S, Hayakawa K, Hineno S, Okamoto T, Watanabe M, Woltjen K, Ikeya M, Kato T Jr, Toguchida J Tamaki S, Fukuta M, Sekiguchi K, Jin Y, Nagata S, Hayakawa K, Hineno S, Okamoto T, Watanabe M, Woltjen K, Ikeya M, Kato T Jr, Toguchida J SS18-SSX, the Oncogenic Fusion Protein in Synovial Sarcoma, Is a Cellular Context-Dependent Epigenetic Modifier. SS18-SSX, the Oncogenic Fusion Protein in Synovial Sarcoma, Is a Cellular Context-Dependent Epigenetic Modifier. SS18-SSX, the Oncogenic Fusion Protein in Synovial Sarcoma, Is a Cellular Context-Dependent Epigenetic Modifier. PloS one, 10, 11, e0142991 PloS one, 10, 11, e0142991 PloS one, 10, 11, e0142991 2015 有 公開
Jin Y, Elalaf H, Watanabe M, Tamaki S, Hineno S, Matsunaga K, Woltjen K, Kobayashi Y, Nagata S, Ikeya M, Kato T Jr, Okamoto T, Matsuda S, Toguchida J Jin Y, Elalaf H, Watanabe M, Tamaki S, Hineno S, Matsunaga K, Woltjen K, Kobayashi Y, Nagata S, Ikeya M, Kato T Jr, Okamoto T, Matsuda S, Toguchida J Jin Y, Elalaf H, Watanabe M, Tamaki S, Hineno S, Matsunaga K, Woltjen K, Kobayashi Y, Nagata S, Ikeya M, Kato T Jr, Okamoto T, Matsuda S, Toguchida J Mutant IDH1 Dysregulates the Differentiation of Mesenchymal Stem Cells in Association with Gene-Specific Histone Modifications to Cartilage- and Bone-Related Genes. Mutant IDH1 Dysregulates the Differentiation of Mesenchymal Stem Cells in Association with Gene-Specific Histone Modifications to Cartilage- and Bone-Related Genes. Mutant IDH1 Dysregulates the Differentiation of Mesenchymal Stem Cells in Association with Gene-Specific Histone Modifications to Cartilage- and Bone-Related Genes. PloS one, 10, 7, e0131998 PloS one, 10, 7, e0131998 PloS one, 10, 7, e0131998 2015 有 公開
Ohnishi K, Semi K, Yamamoto T, Shimizu M, Tanaka A, Mitsunaga K, Okita K, Osafune K, Arioka Y, Maeda T, Soejima H, Moriwaki H, Yamanaka S, Woltjen K, Yamada Y Ohnishi K, Semi K, Yamamoto T, Shimizu M, Tanaka A, Mitsunaga K, Okita K, Osafune K, Arioka Y, Maeda T, Soejima H, Moriwaki H, Yamanaka S, Woltjen K, Yamada Y K. Ohnishi; K. Semi; T. Yamamoto; M. Shimizu; A. Tanaka; K. Mitsunaga; K. Okita; K. Osafune; Y. Arioka; T. Maeda; H. Soejima; H. Moriwaki; S. Yamanaka; K. Woltjen; Y. Yamada Premature termination of reprogramming in vivo leads to cancer development through altered epigenetic regulation. Premature termination of reprogramming in vivo leads to cancer development through altered epigenetic regulation. Premature termination of reprogramming in vivo leads to cancer development through altered epigenetic regulation Cell, 156, 4, 663-677 Cell, 156, 4, 663-677 Cell, 156, 4, 663-677 2014/02 有 英語 公開
Sakuma T, Woltjen K Sakuma T, Woltjen K T. Sakuma; K. Woltjen Nuclease-mediated genome editing: At the front-line of functional genomics technology. Nuclease-mediated genome editing: At the front-line of functional genomics technology. Nuclease-mediated genome editing: At the front-line of functional genomics technology Development, growth & differentiation, 56, 1, 2-13 Development, growth & differentiation, 56, 1, 2-13 Development Growth and Differentiation, 56, 1, 2-13 2014/01 有 英語 公開
WOLTJEN KNUT WOLTJEN KNUT Gallagher D, Norman AA, Woodard CL, Yang G, Gauthier-Fisher A, Fujitani M, Vessey JP, Cancino GI, Sachewsky N, Woltjen K, Fatt MP, Morshead CM, Kaplan DR, Miller FD. Transient maternal IL-6 mediates long-lasting changes in neural stem cell pools by deregulating an endogenous self-renewal pathway. Transient maternal IL-6 mediates long-lasting changes in neural stem cell pools by deregulating an endogenous self-renewal pathway. Transient maternal IL-6 mediates long-lasting changes in neural stem cell pools by deregulating an endogenous self-renewal pathway. Cell Stem Cell, 13, 5, 564-576 Cell Stem Cell, 13, 5, 564-576 Cell Stem Cell, 13, 5, 564-576 2013/11 有 英語 研究論文(学術雑誌) 公開
Sakuma T, Hosoi S, Woltjen K, Suzuki K, Kashiwagi K, Wada H, Ochiai H, Miyamoto T, Kawai N, Sasakura Y, Matsuura S, Okada Y, Kawahara A, Hayashi S, Yamamoto T Sakuma T, Hosoi S, Woltjen K, Suzuki K, Kashiwagi K, Wada H, Ochiai H, Miyamoto T, Kawai N, Sasakura Y, Matsuura S, Okada Y, Kawahara A, Hayashi S, Yamamoto T T. Sakuma; S. Hosoi; K. Woltjen; K.-I. Suzuki; K. Kashiwagi; H. Wada; H. Ochiai; T. Miyamoto; N. Kawai; Y. Sasakura; S. Matsuura; Y. Okada; A. Kawahara; S. Hayashi; T. Yamamoto Efficient TALEN construction and evaluation methods for human cell and animal applications. Efficient TALEN construction and evaluation methods for human cell and animal applications. Efficient TALEN construction and evaluation methods for human cell and animal applications Genes to cells : devoted to molecular & cellular mechanisms, 18, 4, 315-326 Genes to cells : devoted to molecular & cellular mechanisms, 18, 4, 315-326 Genes to Cells, 18, 4, 315-326 2013/04 有 英語 公開
Hayakawa K, Ikeya M, Fukuta M, Woltjen K, Tamaki S, Takahara N, Kato T Jr, Sato S, Otsuka T, Toguchida J Hayakawa K, Ikeya M, Fukuta M, Woltjen K, Tamaki S, Takahara N, Kato T Jr, Sato S, Otsuka T, Toguchida J K. Hayakawa; M. Ikeya; M. Fukuta; K. Woltjen; S. Tamaki; N. Takahara; T. Kato; S. Sato; T. Otsuka; J. Toguchida Identification of target genes of synovial sarcoma-associated fusion oncoprotein using human pluripotent stem cells. Identification of target genes of synovial sarcoma-associated fusion oncoprotein using human pluripotent stem cells. Identification of target genes of synovial sarcoma-associated fusion oncoprotein using human pluripotent stem cells Biochemical and biophysical research communications, 432, 4, 713-719 Biochemical and biophysical research communications, 432, 4, 713-719 Biochemical and Biophysical Research Communications, 432, 4, 713-719 2013/03 有 英語 公開
Yamashita A, Liu S, Woltjen K, Thomas B, Meng G, Hotta A, Takahashi K, Ellis J, Yamanaka S, Rancourt DE Yamashita A, Liu S, Woltjen K, Thomas B, Meng G, Hotta A, Takahashi K, Ellis J, Yamanaka S, Rancourt DE A. Yamashita; S. Liu; K. Woltjen; B. Thomas; G. Meng; A. Hotta; K. Takahashi; J. Ellis; S. Yamanaka; D.E. Rancourt Cartilage tissue engineering identifies abnormal human induced pluripotent stem cells. Cartilage tissue engineering identifies abnormal human induced pluripotent stem cells. Cartilage tissue engineering identifies abnormal human induced pluripotent stem cells Scientific reports, 3, 1978 Scientific reports, 3, 1978 Scientific Reports, 3, 1978 2013 有 英語 公開
Tanaka A, Woltjen K, Miyake K, Hotta A, Ikeya M, Yamamoto T, Nishino T, Shoji E, Sehara-Fujisawa A, Manabe Y, Fujii N, Hanaoka K, Era T, Yamashita S, Isobe K, Kimura E, Sakurai H Tanaka A, Woltjen K, Miyake K, Hotta A, Ikeya M, Yamamoto T, Nishino T, Shoji E, Sehara-Fujisawa A, Manabe Y, Fujii N, Hanaoka K, Era T, Yamashita S, Isobe K, Kimura E, Sakurai H A. Tanaka; K. Woltjen; K. Miyake; A. Hotta; M. Ikeya; T. Yamamoto; T. Nishino; E. Shoji; A. Sehara-Fujisawa; Y. Manabe; N. Fujii; K. Hanaoka; T. Era; S. Yamashita; K.-I. Isobe; E. Kimura; H. Sakurai Efficient and reproducible myogenic differentiation from human iPS cells: prospects for modeling Miyoshi Myopathy in vitro. Efficient and reproducible myogenic differentiation from human iPS cells: prospects for modeling Miyoshi Myopathy in vitro. Efficient and Reproducible Myogenic Differentiation from Human iPS Cells: Prospects for Modeling Miyoshi Myopathy In Vitro PloS one, 8, 4, e61540 PloS one, 8, 4, e61540 PLoS ONE, 8, 4, e61540 2013 有 英語 公開
Michael IP, Monetti C, Chiu AC, Zhang P, Baba T, Nishino K, Agha-Mohammadi S, Woltjen K, Sung HK, Nagy A Michael IP, Monetti C, Chiu AC, Zhang P, Baba T, Nishino K, Agha-Mohammadi S, Woltjen K, Sung HK, Nagy A I.P. Michael; C. Monetti; A.C. Chiu; P. Zhang; T. Baba; K. Nishino; S. Agha-Mohammadi; K. Woltjen; H.-K. Sung; A. Nagy Highly efficient site-specific transgenesis in cancer cell lines. Highly efficient site-specific transgenesis in cancer cell lines. Highly efficient site-specific transgenesis in cancer cell lines Molecular cancer, 11, 89 Molecular cancer, 11, 89 Molecular Cancer, 11, 89 2012/12 有 英語 公開
Gabut M, Samavarchi-Tehrani P, Wang X, Slobodeniuc V, O'Hanlon D, Sung HK, Alvarez M, Talukder S, Pan Q, Mazzoni EO, Nedelec S, Wichterle H, Woltjen K, Hughes TR, Zandstra PW, Nagy A, Wrana JL, Blencowe BJ Gabut M, Samavarchi-Tehrani P, Wang X, Slobodeniuc V, O'Hanlon D, Sung HK, Alvarez M, Talukder S, Pan Q, Mazzoni EO, Nedelec S, Wichterle H, Woltjen K, Hughes TR, Zandstra PW, Nagy A, Wrana JL, Blencowe BJ M. Gabut; P. Samavarchi-Tehrani; X. Wang; V. Slobodeniuc; D. O'Hanlon; H.-K. Sung; M. Alvarez; S. Talukder; Q. Pan; E.O. Mazzoni; S. Nedelec; H. Wichterle; K. Woltjen; T.R. Hughes; P.W. Zandstra; A. Nagy; J.L. Wrana; B.J. Blencowe An alternative splicing switch regulates embryonic stem cell pluripotency and reprogramming. An alternative splicing switch regulates embryonic stem cell pluripotency and reprogramming. An alternative splicing switch regulates embryonic stem cell pluripotency and reprogramming Cell, 147, 1, 132-146 Cell, 147, 1, 132-146 Cell, 147, 1, 132-146 2011/09 有 英語 公開
Nagy K, Sung HK, Zhang P, Laflamme S, Vincent P, Agha-Mohammadi S, Woltjen K, Monetti C, Michael IP, Smith LC, Nagy A Nagy K, Sung HK, Zhang P, Laflamme S, Vincent P, Agha-Mohammadi S, Woltjen K, Monetti C, Michael IP, Smith LC, Nagy A K. Nagy; H.-K. Sung; P. Zhang; S. Laflamme; P. Vincent; S. Agha-Mohammadi; K. Woltjen; C. Monetti; I.P. Michael; L.C. Smith; A. Nagy Induced pluripotent stem cell lines derived from equine fibroblasts. Induced pluripotent stem cell lines derived from equine fibroblasts. Induced Pluripotent Stem Cell Lines Derived from Equine Fibroblasts Stem cell reviews, 7, 3, 693-702 Stem cell reviews, 7, 3, 693-702 Stem Cell Reviews and Reports, 7, 3, 693-702 2011/09 有 英語 公開
Monetti C, Nishino K, Biechele S, Zhang P, Baba T, Woltjen K, Nagy A Monetti C, Nishino K, Biechele S, Zhang P, Baba T, Woltjen K, Nagy A C. Monetti; K. Nishino; S. Biechele; P. Zhang; T. Baba; K. Woltjen; A. Nagy PhiC31 integrase facilitates genetic approaches combining multiple recombinases. PhiC31 integrase facilitates genetic approaches combining multiple recombinases. PhiC31 integrase facilitates genetic approaches combining multiple recombinases Methods (San Diego, Calif.), 53, 4, 380-385 Methods (San Diego, Calif.), 53, 4, 380-385 Methods, 53, 4, 380-385 2011/04 有 英語 公開
Woltjen K, Hämäläinen R, Kibschull M, Mileikovsky M, Nagy A Woltjen K, Hämäläinen R, Kibschull M, Mileikovsky M, Nagy A K. Woltjen; R. Hämäläinen; M. Kibschull; M. Mileikovsky; A. Nagy Transgene-free production of pluripotent stem cells using piggyBac transposons. Transgene-free production of pluripotent stem cells using piggyBac transposons. Transgene-free production of pluripotent stem cells using piggyBac transposons Methods in molecular biology (Clifton, N.J.), 767, 87-103 Methods in molecular biology (Clifton, N.J.), 767, 87-103 Methods in Molecular Biology, 767, 87-103 2011 有 英語 公開
Samavarchi-Tehrani P, Golipour A, David L, Sung HK, Beyer TA, Datti A, Woltjen K, Nagy A, Wrana JL Samavarchi-Tehrani P, Golipour A, David L, Sung HK, Beyer TA, Datti A, Woltjen K, Nagy A, Wrana JL P. Samavarchi-Tehrani; A. Golipour; L. David; H.-K. Sung; T.A. Beyer; A. Datti; K. Woltjen; A. Nagy; J.L. Wrana Functional genomics reveals a BMP-driven mesenchymal-to-epithelial transition in the initiation of somatic cell reprogramming. Functional genomics reveals a BMP-driven mesenchymal-to-epithelial transition in the initiation of somatic cell reprogramming. Functional genomics reveals a BMP-Driven mesenchymal-to-Epithelial transition in the initiation of somatic cell reprogramming Cell stem cell, 7, 1, 64-77 Cell stem cell, 7, 1, 64-77 Cell Stem Cell, 7, 1, 64-77 2010/07 有 英語 公開
Woltjen K, Stanford WL Woltjen K, Stanford WL K. Woltjen; W.L. Stanford Preview. Inhibition of Tgf-beta signaling improves mouse fibroblast reprogramming. Preview. Inhibition of Tgf-beta signaling improves mouse fibroblast reprogramming. Inhibition of Tgf-β Signaling Improves Mouse Fibroblast Reprogramming Cell stem cell, 5, 5, 457-458 Cell stem cell, 5, 5, 457-458 Cell Stem Cell, 5, 5, 457-458 2009/11 有 英語 公開
O'Malley J, Woltjen K, Kaji K O'Malley J, Woltjen K, Kaji K J. O'Malley; K. Woltjen; K. Kaji New strategies to generate induced pluripotent stem cells. New strategies to generate induced pluripotent stem cells. New strategies to generate induced pluripotent stem cells Current opinion in biotechnology, 20, 5, 516-521 Current opinion in biotechnology, 20, 5, 516-521 Current Opinion in Biotechnology, 20, 5, 516-521 2009/10 有 英語 公開
Woltjen K, Michael IP, Mohseni P, Desai R, Mileikovsky M, Hämäläinen R, Cowling R, Wang W, Liu P, Gertsenstein M, Kaji K, Sung HK, Nagy A Woltjen K, Michael IP, Mohseni P, Desai R, Mileikovsky M, Hämäläinen R, Cowling R, Wang W, Liu P, Gertsenstein M, Kaji K, Sung HK, Nagy A K. Woltjen; I.P. Michael; P. Mohseni; R. Desai; M. Mileikovsky; R. Hämäläinen; R. Cowling; W. Wang; P. Liu; M. Gertsenstein; K. Kaji; H.-K. Sung; A. Nagy piggyBac transposition reprograms fibroblasts to induced pluripotent stem cells. piggyBac transposition reprograms fibroblasts to induced pluripotent stem cells. PiggyBac transposition reprograms fibroblasts to induced pluripotent stem cells Nature, 458, 7239, 766-770 Nature, 458, 7239, 766-770 Nature, 458, 7239, 766-770 2009/04 有 英語 公開
Kaji K, Norrby K, Paca A, Mileikovsky M, Mohseni P, Woltjen K Kaji K, Norrby K, Paca A, Mileikovsky M, Mohseni P, Woltjen K K. Kaji; K. Norrby; A. Paca; M. Mileikovsky; P. Mohseni; K. Woltjen Virus-free induction of pluripotency and subsequent excision of reprogramming factors. Virus-free induction of pluripotency and subsequent excision of reprogramming factors. Virus-free induction of pluripotency and subsequent excision of reprogramming factors Nature, 458, 7239, 771-775 Nature, 458, 7239, 771-775 Nature, 458, 7239, 771-775 2009/04 有 英語 公開
Woltjen K, Ito K, Tsuzuki T, Rancourt DE Woltjen K, Ito K, Tsuzuki T, Rancourt DE Woltjen K, Ito K, Tsuzuki T, Rancourt DE Orpheus recombination : a comprehensive bacteriophage system for murine targeting vector construction by transplacement. Orpheus recombination : a comprehensive bacteriophage system for murine targeting vector construction by transplacement. Orpheus recombination : a comprehensive bacteriophage system for murine targeting vector construction by transplacement. Methods in molecular biology (Clifton, N.J.), 435, 79-94 Methods in molecular biology (Clifton, N.J.), 435, 79-94 Methods in molecular biology (Clifton, N.J.), 435, 79-94 2008 有 公開
Thomas B, Woltjen K, Rancourt DE Thomas B, Woltjen K, Rancourt DE B. Thomas; K. Woltjen; D.E. Rancourt Deep screening of recombination proficient bacteriophage libraries. Deep screening of recombination proficient bacteriophage libraries. Deep screening of recombination proficient bacteriophage libraries BioTechniques, 34, 1, 36-8, 40 BioTechniques, 34, 1, 36-8, 40 BioTechniques, 34, 1, 36-8, 40 2003/01 有 英語 公開
Woltjen K, Unger MW, Rancourt DE Woltjen K, Unger MW, Rancourt DE K. Woltjen; M.W. Unger; D.E. Rancourt Transplacement mutagenesis. A recombination-based in situ mutagenesis protocol. Transplacement mutagenesis. A recombination-based in situ mutagenesis protocol. Transplacement mutagenesis. A recombination-based in situ mutagenesis protocol. Methods in molecular biology (Clifton, N.J.), 182, 189-207 Methods in molecular biology (Clifton, N.J.), 182, 189-207 Methods in molecular biology (Clifton, N.J.), 182, 189-207 2002 有 英語 研究論文(学術雑誌) 公開
K. Nagy; H.-K. Sung; P. Zhang; S. Laflamme; P. Vincent; S. Agha-Mohammadi; K. Woltjen; C. Monetti; I.P. Michael; L.C. Smith; A. Nagy K. Nagy; H.-K. Sung; P. Zhang; S. Laflamme; P. Vincent; S. Agha-Mohammadi; K. Woltjen; C. Monetti; I.P. Michael; L.C. Smith; A. Nagy Erratum to: Induced Pluripotent Stem Cell Lines Derived from Equine Fibroblasts (Stem Cell Rev and Rep, 10.1007/s12015-011-9239-5) Erratum to: Induced Pluripotent Stem Cell Lines Derived from Equine Fibroblasts (Stem Cell Rev and Rep, 10.1007/s12015-011-9239-5) Stem Cell Reviews and Reports, 8, 2, 546- , 8, 2, 546- Stem Cell Reviews and Reports, 8, 2, 546- 2012 有 英語 公開
Woltjen K, Hamalainen R, Kibschull M, Mileikovsky M, Nagy A. Woltjen K, Hamalainen R, Kibschull M, Mileikovsky M, Nagy A. Transposon-based production of genetically unmodified induced pluripotent stem cells from human embryonic fibroblasts Transposon-based production of genetically unmodified induced pluripotent stem cells from human embryonic fibroblasts Methods in Molecular Biology 767 (87):103 Methods in Molecular Biology 767 (87):103 2011 有 英語 公開
K. Sciabica; K. Woltjen; A. Hotta K. Sciabica; K. Woltjen; A. Hotta Obtaining Pluripotency Biomarker Signatures Obtaining Pluripotency Biomarker Signatures Genetic Engineering and Biotechnology News, 30, 3 , 30, 3 Genetic Engineering and Biotechnology News, 30, 3 2010 英語 公開
C. Aoyama; K. Woltjen; F.C. Mansergh; K. Ishidate; D.E. Rancourt C. Aoyama; K. Woltjen; F.C. Mansergh; K. Ishidate; D.E. Rancourt Bacteriophage gene targeting vectors generated by transplacement Bacteriophage gene targeting vectors generated by transplacement BioTechniques, 33, 4, 806-812 , 33, 4, 806-812 BioTechniques, 33, 4, 806-812 2002 有 英語 公開
K. Woltjen; G. Bain; D.E. Rancourt K. Woltjen; G. Bain; D.E. Rancourt Retro-recombination screening of a mouse embryonic stem cell genomic library. Retro-recombination screening of a mouse embryonic stem cell genomic library. Nucleic acids research, 28, 9, E41 , 28, 9, E41 Nucleic acids research, 28, 9, E41 2000 有 英語 公開

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著者 著者(日本語) 著者(英語) タイトル タイトル(日本語) タイトル(英語) 書誌情報等 書誌情報等(日本語) 書誌情報等(英語) 出版年月 査読の有無 記述言語 掲載種別 公開
早川和男,福田誠,玉置さくら,佐藤信吾,池谷真,大塚隆信,Knut Woltjen,戸口田淳也 早川和男,福田誠,玉置さくら,佐藤信吾,池谷真,大塚隆信,Knut Woltjen,戸口田淳也 薬剤誘導型発現ベクターを用いたSYT-SSX 融合遺伝子導入iPS 細胞の樹立 薬剤誘導型発現ベクターを用いたSYT-SSX 融合遺伝子導入iPS 細胞の樹立 第45 回日本整形外科学会骨軟部腫瘍学術 集会（2012.7.15．東京） 第45 回日本整形外科学会骨軟部腫瘍学術 集会（2012.7.15．東京） 2012 有 日本語 公開
福田誠,早川和男,玉置さくら,沖田圭介,池谷真,Knut Woltjen,大塚隆信,戸口田淳也 福田誠,早川和男,玉置さくら,沖田圭介,池谷真,Knut Woltjen,大塚隆信,戸口田淳也 PS 細胞を用いた肉腫研究：滑膜肉腫の起源細胞の解明をめざして PS 細胞を用いた肉腫研究：滑膜肉腫の起源細胞の解明をめざして 第27 回日本整形外科学会基礎学術集会（2012.10.26． 名古屋） 第27 回日本整形外科学会基礎学術集会（2012.10.26． 名古屋） 2012 有 日本語 公開
Hayakawa K, Fukuta M, TamaiS, Kato T, Ikeya M, Otsuka T, Woltjen K, Toguchida J. Hayakawa K, Fukuta M, TamaiS, Kato T, Ikeya M, Otsuka T, Woltjen K, Toguchida J. Application of iPS cell technology \nfor the analysis of origin-unknown sarcoma characterized by a specific fusion gene． Application of iPS cell technology \nfor the analysis of origin-unknown sarcoma characterized by a specific fusion gene． 第17 回CTOS （2012.11.16．Prague） 第17 回CTOS （2012.11.16．Prague） 2012/11/16 有 英語 公開
Fukuta M, Hayakawa K, Tamaki S, Sato S, Ikeya M, Otsuka Y, Woltjen K, Toguchida J. Fukuta M, Hayakawa K, Tamaki S, Sato S, Ikeya M, Otsuka Y, Woltjen K, Toguchida J. Establishment and functional \nanalysis of iPS cells with drug-inducible SYT-SSX fusion gene． Establishment and functional \nanalysis of iPS cells with drug-inducible SYT-SSX fusion gene． 第10 回ISSCR（2012.6.14．横浜） 第10 回ISSCR（2012.6.14．横浜） 2012 有 英語 公開
タイトル言語:
講演・口頭発表等
タイトル タイトル(日本語) タイトル(英語) 会議名 会議名(日本語) 会議名(英語) 主催者 主催者(日本語) 主催者(英語) 開催年月日 記述言語 会議種別 公開
Precise Human Disease Allele Creation and Correction through Microhomology-Mediated End Joining[招待あり] Precise Human Disease Allele Creation and Correction through Microhomology-Mediated End Joining [招待あり] Precise Human Disease Allele Creation and Correction through Microhomology-Mediated End Joining [招待あり] 2019 Keystone Symposia 『Genome Engineering: From Mechanisms to Therapies (B4)』 2019 Keystone Symposia 『Genome Engineering: From Mechanisms to Therapies (B4)』 2019 Keystone Symposia 『Genome Engineering: From Mechanisms to Therapies (B4)』 2019/02/21 英語 口頭発表(招待・特別) 公開
The history and potential of iPSC research[招待あり] The history and potential of iPSC research [招待あり] The history and potential of iPSC research [招待あり] AAAS 2019 Annual Meeting AAAS 2019 Annual Meeting AAAS 2019 Annual Meeting 2019/02/15 英語 口頭発表(招待・特別) 公開
医療応用に向けたヒトiPS細胞でのゲノム編集[招待あり] 医療応用に向けたヒトiPS細胞でのゲノム編集 [招待あり] OPERA「ゲノム編集」産学共創コンソーシアム・公開シンポジウム、卓越大学院キックオフシンポジウム OPERA「ゲノム編集」産学共創コンソーシアム・公開シンポジウム、卓越大学院キックオフシンポジウム 2018/12/10 英語 シンポジウム・ワークショップパネル(指名) 公開
Japan’s experience in regenerative medicine and superdonor cells[招待あり] Japan’s experience in regenerative medicine and superdonor cells [招待あり] Japan’s experience in regenerative medicine and superdonor cells [招待あり] NRC’s HEALTH CHALLENGE PROGRAM WORKSHOP : ‘Transforming Health Outcomes through Engineered Cell and Gene Therapies’ NRC’s HEALTH CHALLENGE PROGRAM WORKSHOP : ‘Transforming Health Outcomes through Engineered Cell and Gene Therapies’ NRC’s HEALTH CHALLENGE PROGRAM WORKSHOP : ‘Transforming Health Outcomes through Engineered Cell and Gene Therapies’ 2018/12/07 英語 シンポジウム・ワークショップパネル(指名) 公開
Precise Human Disease Allele Creation and Correction through Microhomology-Mediated End Joining[招待あり] Precise Human Disease Allele Creation and Correction through Microhomology-Mediated End Joining [招待あり] Precise Human Disease Allele Creation and Correction through Microhomology-Mediated End Joining [招待あり] Concordia University Seminar Concordia University Seminar Concordia University Seminar 2018/12/06 英語 公開講演、セミナー、チュートリアル、講習、講義 公開
Precise human disease allele creation and correction through microhomology-mediated end joining[招待あり] Precise human disease allele creation and correction through microhomology-mediated end joining [招待あり] Precise human disease allele creation and correction through microhomology-mediated end joining [招待あり] 第４１回日本分子生物学会年会 第４１回日本分子生物学会年会 The 41st Annual Meeting of the Molecular Biology Society of Japan 2018/11/28 英語 口頭発表(招待・特別) 公開
Genome editing in stem cells to study the mechanisms of reprogramming and human disease[招待あり] Genome editing in stem cells to study the mechanisms of reprogramming and human disease [招待あり] Genome editing in stem cells to study the mechanisms of reprogramming and human disease [招待あり] Basel Stem Cell Network (BSCN)　International Lecture Series（＠ETH Zürich, D-BSSE） Basel Stem Cell Network (BSCN)　International Lecture Series（＠ETH Zürich, D-BSSE） Basel Stem Cell Network (BSCN)　International Lecture Series（＠ETH Zürich, D-BSSE） 2018/09/14 英語 公開講演、セミナー、チュートリアル、講習、講義 公開
Creation and correction of human disease alleles in iPSCs through microhomology-mediated end joining Creation and correction of human disease alleles in iPSCs through microhomology-mediated end joining Creation and correction of human disease alleles in iPSCs through microhomology-mediated end joining EMBO at BASEL LIFE 2018 EMBO at BASEL LIFE 2018 EMBO at BASEL LIFE 2018 2018/09/13 英語 口頭発表(招待・特別) 公開
Precise human disease allele creation and correction through microhomology-mediated end joining[招待あり] Precise human disease allele creation and correction through microhomology-mediated end joining [招待あり] Precise human disease allele creation and correction through microhomology-mediated end joining [招待あり] IREM seminar（ University of Zurich） IREM seminar（ University of Zurich） IREM seminar（ University of Zurich） 2018/09/12 英語 公開講演、セミナー、チュートリアル、講習、講義 公開
Precise human disease allele creation and correction through microhomology-mediated end joining[招待あり] Precise human disease allele creation and correction through microhomology-mediated end joining [招待あり] Precise human disease allele creation and correction through microhomology-mediated end joining [招待あり] Genome Engineering: The CRISPR-Cas Revolution Genome Engineering: The CRISPR-Cas Revolution Genome Engineering: The CRISPR-Cas Revolution 2018/08/25 英語 口頭発表(招待・特別) 公開
Employing microhomology-mediated end joining for the creation and correction of human disease alleles[招待あり] Employing microhomology-mediated end joining for the creation and correction of human disease alleles [招待あり] Employing microhomology-mediated end joining for the creation and correction of human disease alleles [招待あり] Developmental Biology Guest Research Seminar(Memorial Sloan Kettering Cancer Center) Developmental Biology Guest Research Seminar(Memorial Sloan Kettering Cancer Center) Developmental Biology Guest Research Seminar(Memorial Sloan Kettering Cancer Center) 2018/08/22 英語 公開講演、セミナー、チュートリアル、講習、講義 公開
Scarless editing of human disease alleles through microhomology-mediated end joining (MMEJ)[招待あり] Scarless editing of human disease alleles through microhomology-mediated end joining (MMEJ) [招待あり] Scarless editing of human disease alleles through microhomology-mediated end joining (MMEJ) [招待あり] 日本ゲノム編集学会第3回大会 日本ゲノム編集学会第3回大会 3rd Annual Meeting of The Japanese Society for Genome Editing 2018/06/19 英語 口頭発表(招待・特別) 公開
GENES AND CELLS: THE LIVING DRUGS OF A NEW MEDICAL ERA[招待あり] GENES AND CELLS: THE LIVING DRUGS OF A NEW MEDICAL ERA [招待あり] GENES AND CELLS: THE LIVING DRUGS OF A NEW MEDICAL ERA [招待あり] "Stem Cells and Regenerative Medicine: What does the Future Hold?"　（The University of British Columbia ) "Stem Cells and Regenerative Medicine: What does the Future Hold?"　（The University of British Columbia ) "Stem Cells and Regenerative Medicine: What does the Future Hold?"　（The University of British Columbia ) 2018/03/29 英語 公開講演、セミナー、チュートリアル、講習、講義 公開
The development of induced pluripotent stem cells and emerging tools for genome editing[招待あり] The development of induced pluripotent stem cells and emerging tools for genome editing [招待あり] The development of induced pluripotent stem cells and emerging tools for genome editing [招待あり] "Stem Cells and Regenerative Medicine: What does the Future Hold?"　（The University of British Columbia ) "Stem Cells and Regenerative Medicine: What does the Future Hold?"　（The University of British Columbia ) "Stem Cells and Regenerative Medicine: What does the Future Hold?"　（The University of British Columbia ) 2018/03/28 英語 公開講演、セミナー、チュートリアル、講習、講義 公開
Creation and correction of human disease alleles through microhomology-mediated end joining (MMEJ)[招待あり] Creation and correction of human disease alleles through microhomology-mediated end joining (MMEJ) [招待あり] Creation and correction of human disease alleles through microhomology-mediated end joining (MMEJ) [招待あり] 第9回武田科学振興財団薬科学シンポジウム 第9回武田科学振興財団薬科学シンポジウム The 9th Takeda Science Foundation Symposium on PharmaSciences 2018/02/07 英語 シンポジウム・ワークショップパネル(指名) 公開
Endogenous DNA repair pathways for gene editing in human induced pluripotent stem cells[招待あり] Endogenous DNA repair pathways for gene editing in human induced pluripotent stem cells [招待あり] Endogenous DNA repair pathways for gene editing in human induced pluripotent stem cells [招待あり] Celllular & Physiological Sciences Departmental Seminar（The University of British Columbia ) Celllular & Physiological Sciences Departmental Seminar（The University of British Columbia ) Celllular & Physiological Sciences Departmental Seminar（The University of British Columbia ) 2017/09/14 英語 公開講演、セミナー、チュートリアル、講習、講義 公開
Genetic engineering of iPS cells for modelling genodermatoses[招待あり] Genetic engineering of iPS cells for modelling genodermatoses [招待あり] Genetic engineering of iPS cells for modelling genodermatoses [招待あり] 第38回日本炎症・再生医学会 第38回日本炎症・再生医学会 The 38th Annual Meeting of the Japanese Society of Inflammation and Regeneration 2017/07/19 英語 口頭発表(招待・特別) 公開
Simultaneous derivation of point-mutants and concordant isogenic clones from human iPSCs[招待あり] Simultaneous derivation of point-mutants and concordant isogenic clones from human iPSCs [招待あり] Simultaneous derivation of point-mutants and concordant isogenic clones from human iPSCs [招待あり] 日本ゲノム編集学会第2回大会 日本ゲノム編集学会第2回大会 2nd Annual Meeting of The Japanese Society for Genome Editing 2017/06/29 英語 口頭発表(招待・特別) 公開
Genetic engineering of pluripotent stem cells by CRISPR/Cas[招待あり] Genetic engineering of pluripotent stem cells by CRISPR/Cas [招待あり] Genetic engineering of pluripotent stem cells by CRISPR/Cas [招待あり] 糖尿病ミニシンポジウム「Kyoto Diabetes Mini-Symposium – Beta-Cell Replacement Strategies」 糖尿病ミニシンポジウム「Kyoto Diabetes Mini-Symposium – Beta-Cell Replacement Strategies」 糖尿病ミニシンポジウム「Kyoto Diabetes Mini-Symposium – Beta-Cell Replacement Strategies」 2017/06/05 英語 シンポジウム・ワークショップパネル(指名) 公開
Engineering iPS cell models of human disease[招待あり] Engineering iPS cell models of human disease [招待あり] Engineering iPS cell models of human disease [招待あり] 第75回日本癌学会学術総会 第75回日本癌学会学術総会 The 75th Annual Meeting of the Japanese Cancer Association 2016/10/07 英語 口頭発表(招待・特別) 公開
An epithelial program driven by KLF4 stoichiometry determines hallmarks of somatic cell reprogramming[招待あり] An epithelial program driven by KLF4 stoichiometry determines hallmarks of somatic cell reprogramming [招待あり] An epithelial program driven by KLF4 stoichiometry determines hallmarks of somatic cell reprogramming [招待あり] 熊本大学リエゾンラボ研究会／HIGOプログラム最先端研究セミナー 熊本大学リエゾンラボ研究会／HIGOプログラム最先端研究セミナー Liaison Laboratory Regular Seminar/HIGO Program Cutting-edge Seminar 2016/02/17 英語 公開講演、セミナー、チュートリアル、講習、講義 公開
An epithelial program driven by KLF4 stoichiometry determines hallmarks of somatic cell reprogramming[招待あり] An epithelial program driven by KLF4 stoichiometry determines hallmarks of somatic cell reprogramming [招待あり] An epithelial program driven by KLF4 stoichiometry determines hallmarks of somatic cell reprogramming [招待あり] 九州大学大学院医学研究院 第３５回生命医科学セミナー 九州大学大学院医学研究院 第３５回生命医科学セミナー 2016/02/16 英語 公開講演、セミナー、チュートリアル、講習、講義 公開
At the Conflux of Genome Engineering and Pluripotent Stem Cell Biology[招待あり] At the Conflux of Genome Engineering and Pluripotent Stem Cell Biology [招待あり] At the Conflux of Genome Engineering and Pluripotent Stem Cell Biology [招待あり] Conference on Transposition and Genome Engineering 2015 Conference on Transposition and Genome Engineering 2015 Conference on Transposition and Genome Engineering 2015 2015/11/20 英語 口頭発表(招待・特別) 公開
Engineering the Human Genome: Strategies for iPS Cell Derivation and Disease Modeling[招待あり] Engineering the Human Genome: Strategies for iPS Cell Derivation and Disease Modeling [招待あり] Engineering the Human Genome: Strategies for iPS Cell Derivation and Disease Modeling [招待あり] Wakate International Symposium “Discovery of Medical Sciences,” (WISDoMS) Wakate International Symposium “Discovery of Medical Sciences,” (WISDoMS) Wakate International Symposium “Discovery of Medical Sciences,” (WISDoMS) 2014/11/06 英語 口頭発表(招待・特別) 公開
From Transposons to Nucleases: Genome Engineering Strategies for iPS Cell Derivation and Disease Modeling[招待あり] From Transposons to Nucleases: Genome Engineering Strategies for iPS Cell Derivation and Disease Modeling [招待あり] From Transposons to Nucleases: Genome Engineering Strategies for iPS Cell Derivation and Disease Modeling [招待あり] The 71th of Stem Cell Biology and Regenerative Medicine Forum The 71th of Stem Cell Biology and Regenerative Medicine Forum The 71st of Stem Cell Biology and Regenerative Medicine Forum 2014/06/30 英語 公開講演、セミナー、チュートリアル、講習、講義 公開
Recombinant DNA and Cell Technologies Enabling Human Functional Genomics[招待あり] Recombinant DNA and Cell Technologies Enabling Human Functional Genomics [招待あり] Recombinant DNA and Cell Technologies Enabling Human Functional Genomics [招待あり] Tokyo Tech Bio 2013 Tokyo Tech Bio 2013 Tokyo Tech Bio 2013 2014/01/29 英語 シンポジウム・ワークショップパネル(指名) 公開
Recombinant DNA and Cell Technologies Enabling Human Functional Genomics[招待あり] Recombinant DNA and Cell Technologies Enabling Human Functional Genomics [招待あり] Recombinant DNA and Cell Technologies Enabling Human Functional Genomics [招待あり] Department of Biological Sciences Molecules, Cells, and Systems Seminar Series (University of Alberta) Department of Biological Sciences Molecules, Cells, and Systems Seminar Series (University of Alberta) Department of Biological Sciences Molecules, Cells, and Systems Seminar Series (University of Alberta) 2013/11/04 英語 公開講演、セミナー、チュートリアル、講習、講義 公開
Transposed and targeted expression systems for guiding somatic cell reprogramming and differentiation[招待あり] Transposed and targeted expression systems for guiding somatic cell reprogramming and differentiation [招待あり] Transposed and targeted expression systems for guiding somatic cell reprogramming and differentiation [招待あり] Transposition and Genome Engineering 2013 Transposition and Genome Engineering 2013 Transposition and Genome Engineering 2013 2013/09 英語 口頭発表(招待・特別) 公開
Transposed and Targeted Gene Expression Systems for Guiding Somatic Cell Reprogramming and Differentiation[招待あり] Transposed and Targeted Gene Expression Systems for Guiding Somatic Cell Reprogramming and Differentiation [招待あり] Transposed and Targeted Gene Expression Systems for Guiding Somatic Cell Reprogramming and Differentiation [招待あり] 第４６回日本発生生物学会 第４６回日本発生生物学会 46th Annual Meeting of the Japanese Society of Development Biologists 2013/05/31 英語 口頭発表(招待・特別) 公開
Cell Identity Transitions During Induced Reprogramming to Pluripotency[招待あり] Cell Identity Transitions During Induced Reprogramming to Pluripotency [招待あり] Cell Identity Transitions During Induced Reprogramming to Pluripotency [招待あり] 第７回日本エピジェネティクス研究会年会 第７回日本エピジェネティクス研究会年会 The 7th Annual Meeting of the Japanese Society for Epigenetics 2013/05 英語 口頭発表(招待・特別) 公開
Cell Identity Transitions During Induced Reprogramming to Pluripotency[招待あり] Cell Identity Transitions During Induced Reprogramming to Pluripotency [招待あり] Cell Identity Transitions During Induced Reprogramming to Pluripotency [招待あり] CDB Seminar CDB Seminar CDB Seminar 2013/03/29 英語 公開講演、セミナー、チュートリアル、講習、講義 公開
Transposon Systems to Guiding Somatic Cell Reprogramming and Differentiation[招待あり] Transposon Systems to Guiding Somatic Cell Reprogramming and Differentiation [招待あり] Transposon Systems to Guiding Somatic Cell Reprogramming and Differentiation [招待あり] iCeMS-Stem Cells Australia Joint Symposium iCeMS-Stem Cells Australia Joint Symposium iCeMS-Stem Cells Australia Joint Symposium 2013/02/12 英語 シンポジウム・ワークショップパネル(指名) 公開

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タイトル言語:
書籍等出版物
著者 著者(日本語) 著者(英語) タイトル タイトル(日本語) タイトル(英語) 出版社 出版社(日本語) 出版社(英語) 出版年月 記述言語 担当区分 公開
香川　晴信、松本　智子、金　信一、ウォルツェン　クヌート 香川　晴信、松本　智子、金　信一、ウォルツェン　クヌート Harunobu Kagawa, Tomoko Matsumoto, Shin-Il Kim, and Knut Woltjen iPS細胞を用いた正確な ゲノム編集法(MhAX法) iPS細胞を用いた正確な ゲノム編集法(MhAX法) iPS細胞を用いた正確な ゲノム編集法(MhAX法) 実験医学 実験医学 実験医学 2018/10 分担執筆 公開
タイトル言語:
特許
発明者 発明者(日本語) 発明者(英語) 発明の名称 発明の名称(日本語) 発明の名称(英語) 審査の段階 番号 年月 公開
ウォルツェン　クヌート、金　信一、松本　智子 ウォルツェン　クヌート、金　信一、松本　智子 Knut Woltjen, Shin-Il Kim, Tomoko Matsumoto Method for genome editing Method for genome editing Method for genome editing 特許出願 特願PCT/IB2017/054736 2017/08/02 公開
タイトル言語:
外部資金：競争的資金・科学研究費補助金
種別 代表/分担 テーマ(日本語) テーマ(英語) 期間
若手研究（Ｂ） 代表 トランスポゾンを利用した一塩基レベル遺伝子ターゲティング 2011〜2013
外部資金：競争的資金・科学研究費補助金以外
制度名 代表者名 研究課題(日本語) 研究課題(英語) 期間
リプログラミング開始における細胞応答の解析 Immediate Early Events in Reprogramming Leading to Cellular Plasticity 2010〜2012
担当科目
講義名(日本語) 講義名(英語) 開講期 学部/研究科 年度
Global Frontier in Life Science A Global Frontier in Life Science A 前期 生命科学研究科 2013/04〜2014/03
Global Frontier in Life Science A Global Frontier in Life Science A 前期 生命科学研究科 2014/04〜2015/03
Global Frontier in Life Science A Global Frontier in Life Science A 前期 生命科学研究科 2015/04〜2016/03

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