井上実

最終更新日時: 2019/11/14 10:08:36

氏名(漢字／フリガナ／アルファベット表記)

井上実／イノウエミノル／Inoue, Minoru

所属部署・職名(部局／所属／講座等／職名)

医学部附属病院／放射線科（放射線治療科）／助教

取得学位

学位名(日本語)	学位名(英語)	大学(日本語)	大学(英語)	取得区分
博士（医学）		京都大学

職歴

期間	組織名(日本語)	組織名(英語)	職名(日本語)	職名(英語)
2015/04/01〜2018/03/31	プリンセスマーガレットキャンサーセンター	Princess Margaret Cancer Centre	博士研究員	Post-doctoral Fellow

ORCID ID

https://orcid.org/0000-0002-6312-6757

researchmap URL

https://researchmap.jp/7000023103

研究テーマ

(日本語)
放射線腫瘍学、がんの転移、レドックス恒常性、好中球細胞外トラップ、エッジコンピューティング、マイクロ内視鏡
(英語)
Radiation Oncology, Cancer metastasis, Redox homeostasis, Neutrophil extracellular traps (NETs), edge computing, microendoscopy

研究概要

(日本語)
個々のがん細胞の特徴に応じて、放射線治療を最適化することにより、放射線抵抗性を示すがん種を含めた全てのがんの克服を目指している。具体的には、培養細胞・動物モデル・臨床検体を用いた分子生物学的解析だけでなく、エッジコンピューティング技術と生体マイクロイメージングを融合させた内視鏡デバイスの開発にも携わり、個々の放射線感受性および治療後の転移リスクを予測する方法の確立を目指している。
(英語)
My research focus is on improving outcomes for patients with cancers exhibiting radioresistance through personalized treatments. Our laboratory is currently developing and validating blood-based biomarkers to predict the radiosensitivity of cancer and the future risk of distant metastasis.

研究分野（キーワード）

キーワード(日本語)	キーワード(英語)
がん	Cancer
放射線治療	Radiation Therapy
放射線生物学	Radiation Biology
活性酸素種	Reactive Oxygen Species
血清アルブミン	Serum Albumin
好中球	Neutrophil
好中球細胞外トラップ	Neutrophil Extracellular Traps
エッジコンピューティング	edge computing
マイクロ内視鏡	micro endoscopy

論文

著者	著者(日本語)	著者(英語)	タイトル	タイトル(日本語)	タイトル(英語)	書誌情報等	書誌情報等(日本語)	書誌情報等(英語)	出版年月	査読の有無	公開
Inoue M, Nakashima R, Enomoto M, Koike Y, Zhao X, Yip K, Huang SH, Waldron JN, Ikura M, Liu FF, Bratman SV	Inoue M, Nakashima R, Enomoto M, Koike Y, Zhao X, Yip K, Huang SH, Waldron JN, Ikura M, Liu FF, Bratman SV	Inoue M, Nakashima R, Enomoto M, Koike Y, Zhao X, Yip K, Huang SH, Waldron JN, Ikura M, Liu FF, Bratman SV	Plasma redox imbalance caused by albumin oxidation promotes lung-predominant NETosis and pulmonary cancer metastasis.	Plasma redox imbalance caused by albumin oxidation promotes lung-predominant NETosis and pulmonary cancer metastasis.	Plasma redox imbalance caused by albumin oxidation promotes lung-predominant NETosis and pulmonary cancer metastasis.	Nature communications, 9, 1, 5116	Nature communications, 9, 1, 5116	Nature communications, 9, 1, 5116	2018/11	有	公開
Ono Y, Yoshimura M, Hirata K, Ono T, Hirashima H, Mukumoto N, Nakamura M, Inoue M, Hiraoka M, Mizowaki T	Ono Y, Yoshimura M, Hirata K, Ono T, Hirashima H, Mukumoto N, Nakamura M, Inoue M, Hiraoka M, Mizowaki T	Ono Y, Yoshimura M, Hirata K, Ono T, Hirashima H, Mukumoto N, Nakamura M, Inoue M, Hiraoka M, Mizowaki T	Dosimetric advantages afforded by a new irradiation technique, Dynamic WaveArc, used for accelerated partial breast irradiation.	Dosimetric advantages afforded by a new irradiation technique, Dynamic WaveArc, used for accelerated partial breast irradiation.	Dosimetric advantages afforded by a new irradiation technique, Dynamic WaveArc, used for accelerated partial breast irradiation.	Physica medica : PM : an international journal devoted to the applications of physics to medicine and biology : official journal of the Italian Association of Biomedical Physics (AIFB), 48, 103-110	Physica medica : PM : an international journal devoted to the applications of physics to medicine and biology : official journal of the Italian Association of Biomedical Physics (AIFB), 48, 103-110	Physica medica : PM : an international journal devoted to the applications of physics to medicine and biology : official journal of the Italian Association of Biomedical Physics (AIFB), 48, 103-110	2018/04	有	公開
Hirata K, Yoshimura M, Mukumoto N, Nakamura M, Inoue M, Sasaki M, Fujimoto T, Yano S, Nakata M, Mizowaki T, Hiraoka M	Hirata K, Yoshimura M, Mukumoto N, Nakamura M, Inoue M, Sasaki M, Fujimoto T, Yano S, Nakata M, Mizowaki T, Hiraoka M	Hirata K, Yoshimura M, Mukumoto N, Nakamura M, Inoue M, Sasaki M, Fujimoto T, Yano S, Nakata M, Mizowaki T, Hiraoka M	Three-dimensional intrafractional internal target motions in accelerated partial breast irradiation using three-dimensional conformal external beam radiotherapy.	Three-dimensional intrafractional internal target motions in accelerated partial breast irradiation using three-dimensional conformal external beam radiotherapy.	Three-dimensional intrafractional internal target motions in accelerated partial breast irradiation using three-dimensional conformal external beam radiotherapy.	Radiotherapy and oncology : journal of the European Society for Therapeutic Radiology and Oncology, 124, 1, 118-123	Radiotherapy and oncology : journal of the European Society for Therapeutic Radiology and Oncology, 124, 1, 118-123	Radiotherapy and oncology : journal of the European Society for Therapeutic Radiology and Oncology, 124, 1, 118-123	2017/07	有	公開
Hirata K, Yoshimura M, Inoue M, Yamauchi C, Ogura M, Toi M, Suzuki E, Takeuchi M, Takada M, Hiraoka M	Hirata K, Yoshimura M, Inoue M, Yamauchi C, Ogura M, Toi M, Suzuki E, Takeuchi M, Takada M, Hiraoka M	Hirata K, Yoshimura M, Inoue M, Yamauchi C, Ogura M, Toi M, Suzuki E, Takeuchi M, Takada M, Hiraoka M	Regional recurrence in breast cancer patients with one to three positive axillary lymph nodes treated with breast-conserving surgery and whole breast irradiation.	Regional recurrence in breast cancer patients with one to three positive axillary lymph nodes treated with breast-conserving surgery and whole breast irradiation.	Regional recurrence in breast cancer patients with one to three positive axillary lymph nodes treated with breast-conserving surgery and whole breast irradiation.	Journal of radiation research, 58, 1, 79-85	Journal of radiation research, 58, 1, 79-85	Journal of radiation research, 58, 1, 79-85	2017/01	有	公開
Inoue M, Yoshimura M, Kobayashi M, Morinibu A, Itasaka S, Hiraoka M, Harada H	Inoue M, Yoshimura M, Kobayashi M, Morinibu A, Itasaka S, Hiraoka M, Harada H	Inoue M, Yoshimura M, Kobayashi M, Morinibu A, Itasaka S, Hiraoka M, Harada H	PLK1 blockade enhances therapeutic effects of radiation by inducing cell cycle arrest at the mitotic phase.	PLK1 blockade enhances therapeutic effects of radiation by inducing cell cycle arrest at the mitotic phase.	PLK1 blockade enhances therapeutic effects of radiation by inducing cell cycle arrest at the mitotic phase.	Scientific reports, 5, 15666	Scientific reports, 5, 15666	Scientific reports, 5, 15666	2015/10	有	公開
Inoue M, Yoshimura M, Sato S, Nakamura M, Yamada M, Hirata K, Sasaki M, Fujimoto T, Ogura M, Hiraoka M	Inoue M, Yoshimura M, Sato S, Nakamura M, Yamada M, Hirata K, Sasaki M, Fujimoto T, Ogura M, Hiraoka M	Inoue M, Yoshimura M, Sato S, Nakamura M, Yamada M, Hirata K, Sasaki M, Fujimoto T, Ogura M, Hiraoka M	Improvement of registration accuracy in accelerated partial breast irradiation using the point-based rigid-body registration algorithm for patients with implanted fiducial markers.	Improvement of registration accuracy in accelerated partial breast irradiation using the point-based rigid-body registration algorithm for patients with implanted fiducial markers.	Improvement of registration accuracy in accelerated partial breast irradiation using the point-based rigid-body registration algorithm for patients with implanted fiducial markers.	Medical physics, 42, 4, 1904-1910	Medical physics, 42, 4, 1904-1910	Medical physics, 42, 4, 1904-1910	2015/04	有	公開
Inoue M, Konno M, Ogawa H, Harada H, Asakura H, Fuji H, Murayama S, Nishimura T	Inoue M, Konno M, Ogawa H, Harada H, Asakura H, Fuji H, Murayama S, Nishimura T	Inoue M, Konno M, Ogawa H, Harada H, Asakura H, Fuji H, Murayama S, Nishimura T	A simpler method for total scalp irradiation: the multijaw-size concave arc technique.	A simpler method for total scalp irradiation: the multijaw-size concave arc technique.	A simpler method for total scalp irradiation: the multijaw-size concave arc technique.	Journal of applied clinical medical physics, 15, 4, 4786	Journal of applied clinical medical physics, 15, 4, 4786	Journal of applied clinical medical physics, 15, 4, 4786	2014/07	有	公開
Sasaki M, Nakata M, Inoue M, Sato S, Nakamura M, Fujimoto T, Tsuruta Y, Yano S, Higashimura K, Yoshimura M, Hiraoka M	Sasaki M, Nakata M, Inoue M, Sato S, Nakamura M, Fujimoto T, Tsuruta Y, Yano S, Higashimura K, Yoshimura M, Hiraoka M	Sasaki M, Nakata M, Inoue M, Sato S, Nakamura M, Fujimoto T, Tsuruta Y, Yano S, Higashimura K, Yoshimura M, Hiraoka M	[Use of surgical clips to verify positional accuracy in image-guided accelerated partial breast irradiation].	[Use of surgical clips to verify positional accuracy in image-guided accelerated partial breast irradiation].	[Use of surgical clips to verify positional accuracy in image-guided accelerated partial breast irradiation].	Nihon Hoshasen Gijutsu Gakkai zasshi, 70, 5, 467-475	Nihon Hoshasen Gijutsu Gakkai zasshi, 70, 5, 467-475	Nihon Hoshasen Gijutsu Gakkai zasshi, 70, 5, 467-475	2014/05	有	公開
タイトル言語:

講演・口頭発表等

タイトル	タイトル(日本語)	タイトル(英語)	会議名	会議名(日本語)	会議名(英語)	開催年月日	記述言語	会議種別	公開
Plasma Redox Imbalance Caused by Albumin Oxidation Promotes Lung-Predominant NETosis and Metastasis in Patients Treated With Definitive Radiation Therapy	Plasma Redox Imbalance Caused by Albumin Oxidation Promotes Lung-Predominant NETosis and Metastasis in Patients Treated With Definitive Radiation Therapy	Plasma Redox Imbalance Caused by Albumin Oxidation Promotes Lung-Predominant NETosis and Metastasis in Patients Treated With Definitive Radiation Therapy	2018 ASTRO annual meeting	2018 ASTRO annual meeting	2018 ASTRO annual meeting	2018/10/20	英語	口頭発表(一般)	公開
Intravascular redox balance regulates NETosis and cancer metastasis	Intravascular redox balance regulates NETosis and cancer metastasis	Intravascular redox balance regulates NETosis and cancer metastasis	Multidisciplinary Head and Neck Cancers Symposium	Multidisciplinary Head and Neck Cancers Symposium	Multidisciplinary Head and Neck Cancers Symposium	2018/02/15	英語	ポスター発表	公開
Starvation condition triggers neutrophil extracellular traps	Starvation condition triggers neutrophil extracellular traps	Starvation condition triggers neutrophil extracellular traps	Personalizing Cancer Medicine in 2016 Conference	Personalizing Cancer Medicine in 2016 Conference	Personalizing Cancer Medicine in 2016 Conference	2016/02/01	英語	ポスター発表	公開
PLK1 blockade enhances therapeutic effects of radiation by inducing cell cycle arrest at the mitotic phase	PLK1 blockade enhances therapeutic effects of radiation by inducing cell cycle arrest at the mitotic phase	PLK1 blockade enhances therapeutic effects of radiation by inducing cell cycle arrest at the mitotic phase	第17回癌治療増感シンポジウム	第17回癌治療増感シンポジウム		2014/12/11	日本語	口頭発表(一般)	公開
A novel small molecule inhibitor of PLK1, TAK-960, sensitizes therapeutic effect of radiation by inducing mitotic arrest.	A novel small molecule inhibitor of PLK1, TAK-960, sensitizes therapeutic effect of radiation by inducing mitotic arrest.	novel small molecule inhibitor of PLK1, TAK-960, sensitizes therapeutic effect of radiation by inducing mitotic arrest.	第20回癌治療増感研究会	第20回癌治療増感研究会		2014/06/06	日本語	口頭発表(一般)	公開
Implementation of a rigid-body registration algorithm that improves setup accuracy for accelerated partial breast irradiation	Implementation of a rigid-body registration algorithm that improves setup accuracy for accelerated partial breast irradiation	Implementation of a rigid-body registration algorithm that improves setup accuracy for accelerated partial breast irradiation	Kyoto Breast Cancer Consensus Conference 2014 International Convention	Kyoto Breast Cancer Consensus Conference 2014 International Convention	Kyoto Breast Cancer Consensus Conference 2014 International Convention	2014/02/20	英語	ポスター発表	公開
タイトル言語:

学術賞等

賞の名称(日本語)	賞の名称(英語)	授与組織名(日本語)	授与組織名(英語)	年月
	Basic/Translational Science Award		American Society for Radiation Oncology (ASTRO)	2018/10/21

外部資金：競争的資金・科学研究費補助金

種別	代表/分担	テーマ(日本語)	テーマ(英語)	期間
若手研究	代表	血清アルブミンの酸化度に基づくがんの放射線感受性予測法の開発		2019/04/01〜2021/03/31

外部資金：競争的資金・科学研究費補助金以外

制度名	代表者名	研究課題(日本語)	期間
藤原記念財団: 平成30年度研究奨励金	井上　実	がんの放射線治療効果における血清アルブミンのレドックス状態の関与の解明	2018/06/01〜2202/03/31
京都大学: 若手研究者スタートアップ研究費	井上　実	血清アルブミンの抗酸化作用に基づくがんの放射線感受性および治療効果予測の検討	2018/04/01〜2018/09/30
武田科学振興財団　医学研究助成	井上　実	がんゲノム医療への導入を見据えたアルブミンのオミックス解析の意義の検討	2019/10/16〜2020/10/16

海外での滞在歴

滞在機関名	部署	研究テーマ	国名	期間
Princess Margaret Cancer Centre	Department of Radiation Oncology	Neutrophil Extracellular Traps and Cancer Metastasis	カナダ	2015/04/01〜2018/03/31

井上 実

井上実