髙瀬 隆一

最終更新日時: 2019/06/27 17:35:52

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氏名(漢字/フリガナ/アルファベット表記)
髙瀬 隆一/タカセ リュウイチ/Takase, Ryuichi
所属部署・職名(部局/所属/講座等/職名)
農学研究科/食品生物科学専攻食品生産工学講座/助教
学部兼担
部局 所属 講座等 職名
農学部
取得学位
学位名(日本語) 学位名(英語) 大学(日本語) 大学(英語) 取得区分
修士(農学) Master of Agriculture 京都大学 KYOTO UNIVERSITY
博士(農学) Doctor of Agriculture, Ph.D. 京都大学 KYOTO UNIVERSITY
ORCID ID
https://orcid.org/0000-0002-7423-9407
researchmap URL
https://researchmap.jp/takase_r
研究テーマ
(日本語)
細胞膜の湾曲・切除・融合にかかる微生物の細胞膜動態制御機構の解明と膜小胞を利用した有用物質生産
(英語)
Studies on elucidation of bacterial cell membrane dynamics regarding curvature, scission, and fusion, and production of useful substances using membrane vesicle
研究概要
(日本語)
膜小胞は脂質二重層から成り、ほぼ全ての生物の細胞が産生する。近年微生物の膜小胞が免疫からの忌避や、疎水性物質の輸送など、重要な生理学的機能をもつことが分かってきた。一方、その形成機構には不明な点が多い。膜小胞の形成にはタンパク質による能動的な細胞膜変形反応が必要であると考えられる。本研究では窒素固定細菌を含む微生物の膜小胞形成機構の解明、並びに膜小胞の形態と機能の制御を通じた有用物質生産を目指す。
(英語)
All domains of life produce membrane vesicle composed of lipid bilayer structure. Recently, bacterial membrane vesicle (MV) has been known to have important physiological functions such as evasion from host immune system or transportation of hydrophobic signal substances. However, the mechanism of MV production remains to be clarified. Active membrane deformation reactions caused by unknown proteins should be necessary for MV production. We aim to elucidate MV formation mechanism of microbes including nitrogen-fixing bacteria and establish a new basic biotechnology to control cell membrane structure and function. The findings will enable us to produce useful substances and transport them through MV.
研究分野(キーワード)
キーワード(日本語) キーワード(英語)
微生物機能 Microbial function
生体膜 Biological membrane
構造生物学 Structural biology
合成生物学 Synthetic biology
論文
著者 著者(日本語) 著者(英語) タイトル タイトル(日本語) タイトル(英語) 書誌情報等 書誌情報等(日本語) 書誌情報等(英語) 出版年月 査読の有無 記述言語 掲載種別 公開
Weterman MAJ, Kuo M, Kenter SB, Gordillo S, Karjosukarso DW, Takase R, Bronk M, Oprescu S, van Ruissen F, Witteveen RJW, Bienfait HME, Breuning M, Verhamme C, Hou YM, de Visser M, Antonellis A, Baas F Weterman MAJ, Kuo M, Kenter SB, Gordillo S, Karjosukarso DW, Takase R, Bronk M, Oprescu S, van Ruissen F, Witteveen RJW, Bienfait HME, Breuning M, Verhamme C, Hou YM, de Visser M, Antonellis A, Baas F Weterman MAJ, Kuo M, Kenter SB, Gordillo S, Karjosukarso DW, Takase R, Bronk M, Oprescu S, van Ruissen F, Witteveen RJW, Bienfait HME, Breuning M, Verhamme C, Hou YM, de Visser M, Antonellis A, Baas F Hypermorphic and hypomorphic AARS alleles in patients with CMT2N expand clinical and molecular heterogeneities. Hypermorphic and hypomorphic AARS alleles in patients with CMT2N expand clinical and molecular heterogeneities. Hypermorphic and hypomorphic AARS alleles in patients with CMT2N expand clinical and molecular heterogeneities. Human molecular genetics, 27, 23, 4036-4050 Human molecular genetics, 27, 23, 4036-4050 Human molecular genetics, 27, 23, 4036-4050 2018/12 公開
Masuda I, Takase R, Matsubara R, Paulines MJ, Gamper H, Limbach PA, Hou YM Masuda I, Takase R, Matsubara R, Paulines MJ, Gamper H, Limbach PA, Hou YM Masuda I, Takase R, Matsubara R, Paulines MJ, Gamper H, Limbach PA, Hou YM Selective terminal methylation of a tRNA wobble base. Selective terminal methylation of a tRNA wobble base. Selective terminal methylation of a tRNA wobble base. Nucleic acids research, 46, 7, e37 Nucleic acids research, 46, 7, e37 Nucleic acids research, 46, 7, e37 2018/04 公開
Oprescu SN, Chepa-Lotrea X, Takase R, Golas G, Markello TC, Adams DR, Toro C, Gropman AL, Hou YM, Malicdan MCV, Gahl WA, Tifft CJ, Antonellis A Oprescu SN, Chepa-Lotrea X, Takase R, Golas G, Markello TC, Adams DR, Toro C, Gropman AL, Hou YM, Malicdan MCV, Gahl WA, Tifft CJ, Antonellis A Oprescu SN, Chepa-Lotrea X, Takase R, Golas G, Markello TC, Adams DR, Toro C, Gropman AL, Hou YM, Malicdan MCV, Gahl WA, Tifft CJ, Antonellis A Compound heterozygosity for loss-of-function GARS variants results in a multisystem developmental syndrome that includes severe growth retardation. Compound heterozygosity for loss-of-function GARS variants results in a multisystem developmental syndrome that includes severe growth retardation. Compound heterozygosity for loss-of-function GARS variants results in a multisystem developmental syndrome that includes severe growth retardation. Human mutation, 38, 10, 1412-1420 Human mutation, 38, 10, 1412-1420 Human mutation, 38, 10, 1412-1420 2017/10 公開
Masuda I, Igarashi T, Sakaguchi R, Nitharwal RG, Takase R, Han KY, Leslie BJ, Liu C, Gamper H, Ha T, Sanyal S, Hou YM Masuda I, Igarashi T, Sakaguchi R, Nitharwal RG, Takase R, Han KY, Leslie BJ, Liu C, Gamper H, Ha T, Sanyal S, Hou YM Masuda I, Igarashi T, Sakaguchi R, Nitharwal RG, Takase R, Han KY, Leslie BJ, Liu C, Gamper H, Ha T, Sanyal S, Hou YM A genetically encoded fluorescent tRNA is active in live-cell protein synthesis. A genetically encoded fluorescent tRNA is active in live-cell protein synthesis. A genetically encoded fluorescent tRNA is active in live-cell protein synthesis. Nucleic acids research, 45, 7, 4081-4093 Nucleic acids research, 45, 7, 4081-4093 Nucleic acids research, 45, 7, 4081-4093 2017/04 公開
Hou YM, Matsubara R, Takase R, Masuda I, Sulkowska JI Hou YM, Matsubara R, Takase R, Masuda I, Sulkowska JI Hou YM, Matsubara R, Takase R, Masuda I, Sulkowska JI TrmD: A Methyl Transferase for tRNA Methylation With m<sup>1</sup>G37. TrmD: A Methyl Transferase for tRNA Methylation With m<sup>1</sup>G37. TrmD: A Methyl Transferase for tRNA Methylation With m<sup>1</sup>G37. The Enzymes, 41, 89-115 The Enzymes, 41, 89-115 The Enzymes, 41, 89-115 2017 公開
Takase R, Maruyama Y, Oiki S, Mikami B, Murata K, Hashimoto W Takase R, Maruyama Y, Oiki S, Mikami B, Murata K, Hashimoto W Takase R, Maruyama Y, Oiki S, Mikami B, Murata K, Hashimoto W Structural determinants in bacterial 2-keto-3-deoxy-D-gluconate dehydrogenase KduD for dual-coenzyme specificity. Structural determinants in bacterial 2-keto-3-deoxy-D-gluconate dehydrogenase KduD for dual-coenzyme specificity. Structural determinants in bacterial 2-keto-3-deoxy-D-gluconate dehydrogenase KduD for dual-coenzyme specificity. Proteins, 84, 7, 934-947 Proteins, 84, 7, 934-947 Proteins, 84, 7, 934-947 2016/07 公開
Liu C, Stonestrom AJ, Christian T, Yong J, Takase R, Hou YM, Yang X Liu C, Stonestrom AJ, Christian T, Yong J, Takase R, Hou YM, Yang X Liu C, Stonestrom AJ, Christian T, Yong J, Takase R, Hou YM, Yang X Molecular Basis and Consequences of the Cytochrome c-tRNA Interaction. Molecular Basis and Consequences of the Cytochrome c-tRNA Interaction. Molecular Basis and Consequences of the Cytochrome c-tRNA Interaction. The Journal of biological chemistry, 291, 19, 10426-10436 The Journal of biological chemistry, 291, 19, 10426-10436 The Journal of biological chemistry, 291, 19, 10426-10436 2016/05 公開
Falk MJ, Gai X, Shigematsu M, Vilardo E, Takase R, McCormick E, Christian T, Place E, Pierce EA, Consugar M, Gamper HB, Rossmanith W, Hou YM Falk MJ, Gai X, Shigematsu M, Vilardo E, Takase R, McCormick E, Christian T, Place E, Pierce EA, Consugar M, Gamper HB, Rossmanith W, Hou YM Falk MJ, Gai X, Shigematsu M, Vilardo E, Takase R, McCormick E, Christian T, Place E, Pierce EA, Consugar M, Gamper HB, Rossmanith W, Hou YM A novel HSD17B10 mutation impairing the activities of the mitochondrial RNase P complex causes X-linked intractable epilepsy and neurodevelopmental regression. A novel HSD17B10 mutation impairing the activities of the mitochondrial RNase P complex causes X-linked intractable epilepsy and neurodevelopmental regression. A novel HSD17B10 mutation impairing the activities of the mitochondrial RNase P complex causes X-linked intractable epilepsy and neurodevelopmental regression. RNA biology, 13, 5, 477-485 RNA biology, 13, 5, 477-485 RNA biology, 13, 5, 477-485 2016/05 公開
Maruyama Y, Oiki S, Takase R, Mikami B, Murata K, Hashimoto W Maruyama Y, Oiki S, Takase R, Mikami B, Murata K, Hashimoto W Maruyama Y, Oiki S, Takase R, Mikami B, Murata K, Hashimoto W Metabolic fate of unsaturated glucuronic/iduronic acids from glycosaminoglycans: molecular identification and structure determination of streptococcal isomerase and dehydrogenase. Metabolic fate of unsaturated glucuronic/iduronic acids from glycosaminoglycans: molecular identification and structure determination of streptococcal isomerase and dehydrogenase. Metabolic fate of unsaturated glucuronic/iduronic acids from glycosaminoglycans: molecular identification and structure determination of streptococcal isomerase and dehydrogenase. The Journal of biological chemistry, 290, 10, 6281-6292 The Journal of biological chemistry, 290, 10, 6281-6292 The Journal of biological chemistry, 290, 10, 6281-6292 2015/03 公開
Takase R, Mikami B, Kawai S, Murata K, Hashimoto W Takase R, Mikami B, Kawai S, Murata K, Hashimoto W Takase R, Mikami B, Kawai S, Murata K, Hashimoto W Structure-based conversion of the coenzyme requirement of a short-chain dehydrogenase/reductase involved in bacterial alginate metabolism. Structure-based conversion of the coenzyme requirement of a short-chain dehydrogenase/reductase involved in bacterial alginate metabolism. Structure-based conversion of the coenzyme requirement of a short-chain dehydrogenase/reductase involved in bacterial alginate metabolism. The Journal of biological chemistry, 289, 48, 33198-33214 The Journal of biological chemistry, 289, 48, 33198-33214 The Journal of biological chemistry, 289, 48, 33198-33214 2014/11 公開
Hayashi C, Takase R, Momma K, Maruyama Y, Murata K, Hashimoto W Hayashi C, Takase R, Momma K, Maruyama Y, Murata K, Hashimoto W Hayashi C, Takase R, Momma K, Maruyama Y, Murata K, Hashimoto W Alginate-dependent gene expression mechanism in Sphingomonas sp. strain A1. Alginate-dependent gene expression mechanism in Sphingomonas sp. strain A1. Alginate-dependent gene expression mechanism in Sphingomonas sp. strain A1. Journal of bacteriology, 196, 14, 2691-2700 Journal of bacteriology, 196, 14, 2691-2700 Journal of bacteriology, 196, 14, 2691-2700 2014/07 公開
Takase R, Ochiai A, Mikami B, Hashimoto W, Murata K Takase R, Ochiai A, Mikami B, Hashimoto W, Murata K Takase R, Ochiai A, Mikami B, Hashimoto W, Murata K Molecular identification of unsaturated uronate reductase prerequisite for alginate metabolism in Sphingomonas sp. A1. Molecular identification of unsaturated uronate reductase prerequisite for alginate metabolism in Sphingomonas sp. A1. Molecular identification of unsaturated uronate reductase prerequisite for alginate metabolism in Sphingomonas sp. A1. Biochimica et biophysica acta, 1804, 9, 1925-1936 Biochimica et biophysica acta, 1804, 9, 1925-1936 Biochimica et biophysica acta, 1804, 9, 1925-1936 2010/09 公開

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担当科目
講義名(日本語) 講義名(英語) 開講期 学部/研究科 年度
ILASセミナー ILAS Seminar 前期集中 全学共通科目 2019/04〜2020/03
応用微生物学実験及び実験法 Laboratory Course in Applied Microbiology 後期 農学部 2019/04〜2020/03
生化学・微生物学演習 Seminar on Biochemistry and Microbiology 後期 農学部 2019/04〜2020/03