山田 真太郎

最終更新日時: 2019/06/20 09:59:44

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氏名(漢字/フリガナ/アルファベット表記)
山田 真太郎/ヤマダ シンタロウ/Yamada, Shintaro
所属部署・職名(部局/所属/講座等/職名)
医学研究科/医学専攻遺伝医学講座放射線遺伝学/助教
学部兼担
部局 所属 講座等 職名
医学部
取得学位
学位名(日本語) 学位名(英語) 大学(日本語) 大学(英語) 取得区分
修士(理学) 東京大学
博士(理学) 東京大学
ORCID ID
https://orcid.org/0000-0002-4882-0871
researchmap URL
https://researchmap.jp/7000025208
研究テーマ
(日本語)
DNA二重鎖切断修復機構の解明
(英語)
Understanding molecular mechanisms in DNA double-strand break repair
研究概要
(日本語)
放射線などの環境要因や内的要因から自然発生するゲノム切断の多くは切断端が化学修飾された「汚い」切断であり、発がん性の強いDNA損傷である。この「汚い」ゲノム切断の修復はまず切断端を「きれい」(3′末端に水酸基、5′末端にリン酸基が付いた状態)にする必要があるが、分子機構の多くが不明である。山田はこの「汚い」切断を「きれい」な切断にする過程を高解像度で測定するバイオアッセイ系を開発している。
(英語)
Radiation and other naturally occurring exogenous and endogenous DNA damage often generate genomic DNA breaks with chemically modified “dirty” ends, and are highly carcinogenic. DNA repair must start by cleaning “dirty” ends (modifying them into a 3′-OH dNMP and a 5′-P dNMP), but much remains unknown about its molecular mechanism. Yamada wants to understand this process and tries to develop a high-resolution bioassay system to monitor how cells make such “dirty” ends “clean” ends.
研究分野(キーワード)
キーワード(日本語) キーワード(英語)
放射線影響 Radiation influence
化学物質影響 Chemical substance influence
分子生物学 Molecular biology
ゲノム生物学 Genome biology
論文
著者 著者(日本語) 著者(英語) タイトル タイトル(日本語) タイトル(英語) 書誌情報等 書誌情報等(日本語) 書誌情報等(英語) 出版年月 査読の有無 記述言語 掲載種別 公開
Sasanuma H, Tsuda M, Morimoto S, Saha LK, Rahman MM, Kiyooka Y, Fujiike H, Cherniack AD, Itou J, Callen Moreu E, Toi M, Nakada S, Tanaka H, Tsutsui K, Yamada S, Nussenzweig A, Takeda S Sasanuma H, Tsuda M, Morimoto S, Saha LK, Rahman MM, Kiyooka Y, Fujiike H, Cherniack AD, Itou J, Callen Moreu E, Toi M, Nakada S, Tanaka H, Tsutsui K, Yamada S, Nussenzweig A, Takeda S Sasanuma H, Tsuda M, Morimoto S, Saha LK, Rahman MM, Kiyooka Y, Fujiike H, Cherniack AD, Itou J, Callen Moreu E, Toi M, Nakada S, Tanaka H, Tsutsui K, Yamada S, Nussenzweig A, Takeda S BRCA1 ensures genome integrity by eliminating estrogen-induced pathological topoisomerase II-DNA complexes. BRCA1 ensures genome integrity by eliminating estrogen-induced pathological topoisomerase II-DNA complexes. BRCA1 ensures genome integrity by eliminating estrogen-induced pathological topoisomerase II-DNA complexes. Proceedings of the National Academy of Sciences of the United States of America, 115, 45, E10642-E10651 Proceedings of the National Academy of Sciences of the United States of America, 115, 45, E10642-E10651 Proceedings of the National Academy of Sciences of the United States of America, 115, 45, E10642-E10651 2018/11 公開
Yamada S, Kugou K, Ding DQ, Fujita Y, Hiraoka Y, Murakami H, Ohta K, Yamada T Yamada S, Kugou K, Ding DQ, Fujita Y, Hiraoka Y, Murakami H, Ohta K, Yamada T Yamada S, Kugou K, Ding DQ, Fujita Y, Hiraoka Y, Murakami H, Ohta K, Yamada T The conserved histone variant H2A.Z illuminates meiotic recombination initiation. The conserved histone variant H2A.Z illuminates meiotic recombination initiation. The conserved histone variant H2A.Z illuminates meiotic recombination initiation. Current genetics, 64, 5, 1015-1019 Current genetics, 64, 5, 1015-1019 Current genetics, 64, 5, 1015-1019 2018/10 公開
Yamada S, Kugou K, Ding DQ, Fujita Y, Hiraoka Y, Murakami H, Ohta K, Yamada T Yamada S, Kugou K, Ding DQ, Fujita Y, Hiraoka Y, Murakami H, Ohta K, Yamada T Yamada S, Kugou K, Ding DQ, Fujita Y, Hiraoka Y, Murakami H, Ohta K, Yamada T The histone variant H2A.Z promotes initiation of meiotic recombination in fission yeast. The histone variant H2A.Z promotes initiation of meiotic recombination in fission yeast. The histone variant H2A.Z promotes initiation of meiotic recombination in fission yeast. Nucleic acids research, 46, 2, 609-620 Nucleic acids research, 46, 2, 609-620 Nucleic acids research, 46, 2, 609-620 2018/01 公開
Yamada S, Kim S, Tischfield SE, Jasin M, Lange J, Keeney S Yamada S, Kim S, Tischfield SE, Jasin M, Lange J, Keeney S Yamada S, Kim S, Tischfield SE, Jasin M, Lange J, Keeney S Genomic and chromatin features shaping meiotic double-strand break formation and repair in mice. Genomic and chromatin features shaping meiotic double-strand break formation and repair in mice. Genomic and chromatin features shaping meiotic double-strand break formation and repair in mice. Cell cycle (Georgetown, Tex.), 16, 20, 1870-1884 Cell cycle (Georgetown, Tex.), 16, 20, 1870-1884 Cell cycle (Georgetown, Tex.), 16, 20, 1870-1884 2017/10 公開
Yamada S, Okamura M, Oda A, Murakami H, Ohta K, Yamada T Yamada S, Okamura M, Oda A, Murakami H, Ohta K, Yamada T Yamada S, Okamura M, Oda A, Murakami H, Ohta K, Yamada T Correlation of Meiotic DSB Formation and Transcription Initiation Around Fission Yeast Recombination Hotspots. Correlation of Meiotic DSB Formation and Transcription Initiation Around Fission Yeast Recombination Hotspots. Correlation of Meiotic DSB Formation and Transcription Initiation Around Fission Yeast Recombination Hotspots. Genetics, 206, 2, 801-809 Genetics, 206, 2, 801-809 Genetics, 206, 2, 801-809 2017/06 公開
Mimitou EP, Yamada S, Keeney S Mimitou EP, Yamada S, Keeney S Mimitou EP, Yamada S, Keeney S A global view of meiotic double-strand break end resection. A global view of meiotic double-strand break end resection. A global view of meiotic double-strand break end resection. Science (New York, N.Y.), 355, 6320, 40-45 Science (New York, N.Y.), 355, 6320, 40-45 Science (New York, N.Y.), 355, 6320, 40-45 2017/01 公開
Lange J, Yamada S, Tischfield S. E, Pan J, Kim S, Zhu X, Socci N. D, Jasin M, Keeney S. Lange J, Yamada S, Tischfield S. E, Pan J, Kim S, Zhu X, Socci N. D, Jasin M, Keeney S. Lange J, Yamada S, Tischfield S. E, Pan J, Kim S, Zhu X, Socci N. D, Jasin M, Keeney S. The landscape of mouse meiotic double-strand break formation, processing, and repair The landscape of mouse meiotic double-strand break formation, processing, and repair The landscape of mouse meiotic double-strand break formation, processing, and repair Cell, 167, 3, 695-708.e16 Cell, 167, 3, 695-708.e16 Cell, 167, 3, 695-708.e16 2016/10 公開
Yamada S, Ohta K, Yamada T Yamada S, Ohta K, Yamada T Yamada S, Ohta K, Yamada T Acetylated Histone H3K9 is associated with meiotic recombination hotspots, and plays a role in recombination redundantly with other factors including the H3K4 methylase Set1 in fission yeast. Acetylated Histone H3K9 is associated with meiotic recombination hotspots, and plays a role in recombination redundantly with other factors including the H3K4 methylase Set1 in fission yeast. Acetylated Histone H3K9 is associated with meiotic recombination hotspots, and plays a role in recombination redundantly with other factors including the H3K4 methylase Set1 in fission yeast. Nucleic acids research, 41, 6, 3504-3517 Nucleic acids research, 41, 6, 3504-3517 Nucleic acids research, 41, 6, 3504-3517 2013/04 公開
Miyoshi T, Ito M, Kugou K, Yamada S, Furuichi M, Oda A, Yamada T, Hirota K, Masai H, Ohta K Miyoshi T, Ito M, Kugou K, Yamada S, Furuichi M, Oda A, Yamada T, Hirota K, Masai H, Ohta K Miyoshi T, Ito M, Kugou K, Yamada S, Furuichi M, Oda A, Yamada T, Hirota K, Masai H, Ohta K A central coupler for recombination initiation linking chromosome architecture to S phase checkpoint. A central coupler for recombination initiation linking chromosome architecture to S phase checkpoint. A central coupler for recombination initiation linking chromosome architecture to S phase checkpoint. Molecular cell, 47, 5, 722-733 Molecular cell, 47, 5, 722-733 Molecular cell, 47, 5, 722-733 2012/09 公開
Morita T, Yamada T, Yamada S, Matsumoto K, Ohta K Morita T, Yamada T, Yamada S, Matsumoto K, Ohta K Morita T, Yamada T, Yamada S, Matsumoto K, Ohta K Fission yeast ATF/CREB family protein Atf21 plays important roles in production of normal spores. Fission yeast ATF/CREB family protein Atf21 plays important roles in production of normal spores. Fission yeast ATF/CREB family protein Atf21 plays important roles in production of normal spores. Genes to cells : devoted to molecular & cellular mechanisms, 16, 2, 217-230 Genes to cells : devoted to molecular & cellular mechanisms, 16, 2, 217-230 Genes to cells : devoted to molecular & cellular mechanisms, 16, 2, 217-230 2011/02 公開
Kugou K, Fukuda T, Yamada S, Ito M, Sasanuma H, Mori S, Katou Y, Itoh T, Matsumoto K, Shibata T, Shirahige K, Ohta K Kugou K, Fukuda T, Yamada S, Ito M, Sasanuma H, Mori S, Katou Y, Itoh T, Matsumoto K, Shibata T, Shirahige K, Ohta K Kugou K, Fukuda T, Yamada S, Ito M, Sasanuma H, Mori S, Katou Y, Itoh T, Matsumoto K, Shibata T, Shirahige K, Ohta K Rec8 guides canonical Spo11 distribution along yeast meiotic chromosomes. Rec8 guides canonical Spo11 distribution along yeast meiotic chromosomes. Rec8 guides canonical Spo11 distribution along yeast meiotic chromosomes. Molecular biology of the cell, 20, 13, 3064-3076 Molecular biology of the cell, 20, 13, 3064-3076 Molecular biology of the cell, 20, 13, 3064-3076 2009/07 公開

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タイトル言語:
講演・口頭発表等
タイトル タイトル(日本語) タイトル(英語) 会議名 会議名(日本語) 会議名(英語) 主催者 主催者(日本語) 主催者(英語) 開催年月日 記述言語 会議種別 公開
マウスの減数分裂期のDNA二重鎖切断は反復配列で起こりにくいものの、それでも頻繁に起こっている[招待あり] マウスの減数分裂期のDNA二重鎖切断は反復配列で起こりにくいものの、それでも頻繁に起こっている [招待あり] Mouse meiotic double-strand breaks are underrepresented but nonetheless occur frequently within repeated sequences [招待あり] NYU 反復配列シンポジウム 2017 NYU 反復配列シンポジウム 2017 The 2017 NYU Repetitive DNA Symposium 2017/10/27 英語 シンポジウム・ワークショップパネル(公募) 公開
タイトル言語:
学術賞等
賞の名称(日本語) 賞の名称(英語) 授与組織名(日本語) 授与組織名(英語) 年月
日本学術振興会特別研究員DC1 Research Fellowship for Young Scientists from the Japan Society for the Promotion of Science 日本学術振興会 the Japan Society for the Promotion of Science 2010/04/01
村瀬九郎医師JMSA奨学金 Kuro Murase MD-JMSA Scholarship 米国日本人医師会 Japanese Medical Society of America 2015/05/09
第10回3Rシンポジウムベストポスター賞 The 10th 3R Symposium Best Poster Award 第10回3Rシンポジウム The 10th 3R Symposium 2016/11/16