山田 真太郎

最終更新日時: 2020/08/04 17:51:38

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氏名(漢字/フリガナ/アルファベット表記)
山田 真太郎/ヤマダ シンタロウ/Yamada, Shintaro
所属部署・職名(部局/所属/講座等/職名)
医学研究科/医学専攻遺伝医学講座放射線遺伝学/助教
学部兼担
部局 所属 講座等 職名
医学部
取得学位
学位名(日本語) 学位名(英語) 大学(日本語) 大学(英語) 取得区分
修士(理学) 東京大学
博士(理学) 東京大学
ORCID ID
https://orcid.org/0000-0002-4882-0871
researchmap URL
https://researchmap.jp/7000025208
研究テーマ
(日本語)
DNA二重鎖切断修復機構の解明
(英語)
Understanding molecular mechanisms in DNA double-strand break repair
研究概要
(日本語)
放射線などの環境要因や内的要因から自然発生するゲノム切断の多くは切断端が化学修飾された「汚い」切断であり、発がん性の強いDNA損傷である。この「汚い」ゲノム切断の修復はまず切断端を「きれい」(3′末端に水酸基、5′末端にリン酸基が付いた状態)にする必要があるが、分子機構の多くが不明である。山田はこの「汚い」切断を「きれい」な切断にする過程を高解像度で測定するバイオアッセイ系を開発している。
(英語)
Radiation and other naturally occurring exogenous and endogenous DNA damage often generate genomic DNA breaks with chemically modified “dirty” ends, and are highly carcinogenic. DNA repair must start by cleaning “dirty” ends (modifying them into a 3′-OH dNMP and a 5′-P dNMP), but much remains unknown about its molecular mechanism. Yamada wants to understand this process and tries to develop a high-resolution bioassay system to monitor how cells make such “dirty” ends “clean” ends.
研究分野(キーワード)
キーワード(日本語) キーワード(英語)
放射線影響 Radiation influence
化学物質影響 Chemical substance influence
分子生物学 Molecular biology
ゲノム生物学 Genome biology
論文
著者 著者(日本語) 著者(英語) タイトル タイトル(日本語) タイトル(英語) 書誌情報等 書誌情報等(日本語) 書誌情報等(英語) 出版年月 査読の有無 記述言語 掲載種別 公開
Takatomi Yamada, Shintaro Yamada, Da-Qiao Ding, Yurika Fujita, Emi Takaya, Yasushi Hiraoka, Hiroshi Murakami, Kunihiro Ohta Takatomi Yamada, Shintaro Yamada, Da-Qiao Ding, Yurika Fujita, Emi Takaya, Yasushi Hiraoka, Hiroshi Murakami, Kunihiro Ohta Takatomi Yamada, Shintaro Yamada, Da-Qiao Ding, Yurika Fujita, Emi Takaya, Yasushi Hiraoka, Hiroshi Murakami, Kunihiro Ohta Maintenance of meiotic crossover against reduced double-strand break formation in fission yeast lacking histone H2A.Z. Maintenance of meiotic crossover against reduced double-strand break formation in fission yeast lacking histone H2A.Z. Maintenance of meiotic crossover against reduced double-strand break formation in fission yeast lacking histone H2A.Z. Gene, 743, 144615-144615 Gene, 743, 144615-144615 Gene, 743, 144615-144615 2020/06/15 英語 研究論文(学術雑誌) 公開
Shintaro Yamada, Anjali Gupta Hinch, Hisashi Kamido, Yongwei Zhang, Winfried Edelmann, Scott Keeney Shintaro Yamada, Anjali Gupta Hinch, Hisashi Kamido, Yongwei Zhang, Winfried Edelmann, Scott Keeney Shintaro Yamada, Anjali Gupta Hinch, Hisashi Kamido, Yongwei Zhang, Winfried Edelmann, Scott Keeney Molecular structures and mechanisms of DNA break processing in mouse meiosis. Molecular structures and mechanisms of DNA break processing in mouse meiosis. Molecular structures and mechanisms of DNA break processing in mouse meiosis. Genes & development, 34, 11-12, 806-818 Genes & development, 34, 11-12, 806-818 Genes & development, 34, 11-12, 806-818 2020/06/01 英語 研究論文(学術雑誌) 公開
Remi Akagawa, Hai Thanh Trinh, Liton Kumar Saha, Masataka Tsuda, Kouji Hirota, Shintaro Yamada, Atsushi Shibata, Masato T Kanemaki, Shinichiro Nakada, Shunichi Takeda, Hiroyuki Sasanuma Remi Akagawa, Hai Thanh Trinh, Liton Kumar Saha, Masataka Tsuda, Kouji Hirota, Shintaro Yamada, Atsushi Shibata, Masato T Kanemaki, Shinichiro Nakada, Shunichi Takeda, Hiroyuki Sasanuma Remi Akagawa, Hai Thanh Trinh, Liton Kumar Saha, Masataka Tsuda, Kouji Hirota, Shintaro Yamada, Atsushi Shibata, Masato T Kanemaki, Shinichiro Nakada, Shunichi Takeda, Hiroyuki Sasanuma UBC13-Mediated Ubiquitin Signaling Promotes Removal of Blocking Adducts from DNA Double-Strand Breaks. UBC13-Mediated Ubiquitin Signaling Promotes Removal of Blocking Adducts from DNA Double-Strand Breaks. UBC13-Mediated Ubiquitin Signaling Promotes Removal of Blocking Adducts from DNA Double-Strand Breaks. iScience, 23, 4, 101027-101027 iScience, 23, 4, 101027-101027 iScience, 23, 4, 101027-101027 2020/03/31 英語 研究論文(学術雑誌) 公開
Jacob Paiano, Wei Wu, Shintaro Yamada, Nicholas Sciascia, Elsa Callen, Ana Paola Cotrim, Rajashree A Deshpande, Yaakov Maman, Amanda Day, Tanya T Paull, André Nussenzweig Jacob Paiano, Wei Wu, Shintaro Yamada, Nicholas Sciascia, Elsa Callen, Ana Paola Cotrim, Rajashree A Deshpande, Yaakov Maman, Amanda Day, Tanya T Paull, André Nussenzweig Jacob Paiano, Wei Wu, Shintaro Yamada, Nicholas Sciascia, Elsa Callen, Ana Paola Cotrim, Rajashree A Deshpande, Yaakov Maman, Amanda Day, Tanya T Paull, André Nussenzweig ATM and PRDM9 regulate SPO11-bound recombination intermediates during meiosis. ATM and PRDM9 regulate SPO11-bound recombination intermediates during meiosis. ATM and PRDM9 regulate SPO11-bound recombination intermediates during meiosis. Nature communications, 11, 1, 857-857 Nature communications, 11, 1, 857-857 Nature communications, 11, 1, 857-857 2020/02/12 英語 研究論文(学術雑誌) 公開
Hiroyuki Sasanuma, Masataka Tsuda, Suguru Morimoto, Liton Kumar Saha, Md Maminur Rahman, Yusuke Kiyooka, Haruna Fujiike, Andrew D Cherniack, Junji Itou, Elsa Callen Moreu, Masakazu Toi, Shinichiro Nakada, Hisashi Tanaka, Ken Tsutsui, Shintaro Yamada, Andre Nussenzweig, Shunichi Takeda Hiroyuki Sasanuma, Masataka Tsuda, Suguru Morimoto, Liton Kumar Saha, Md Maminur Rahman, Yusuke Kiyooka, Haruna Fujiike, Andrew D Cherniack, Junji Itou, Elsa Callen Moreu, Masakazu Toi, Shinichiro Nakada, Hisashi Tanaka, Ken Tsutsui, Shintaro Yamada, Andre Nussenzweig, Shunichi Takeda Hiroyuki Sasanuma, Masataka Tsuda, Suguru Morimoto, Liton Kumar Saha, Md Maminur Rahman, Yusuke Kiyooka, Haruna Fujiike, Andrew D Cherniack, Junji Itou, Elsa Callen Moreu, Masakazu Toi, Shinichiro Nakada, Hisashi Tanaka, Ken Tsutsui, Shintaro Yamada, Andre Nussenzweig, Shunichi Takeda BRCA1 ensures genome integrity by eliminating estrogen-induced pathological topoisomerase II-DNA complexes. BRCA1 ensures genome integrity by eliminating estrogen-induced pathological topoisomerase II-DNA complexes. BRCA1 ensures genome integrity by eliminating estrogen-induced pathological topoisomerase II-DNA complexes. Proceedings of the National Academy of Sciences of the United States of America, 115, 45, E10642-E10651-E10651 Proceedings of the National Academy of Sciences of the United States of America, 115, 45, E10642-E10651-E10651 Proceedings of the National Academy of Sciences of the United States of America, 115, 45, E10642-E10651-E10651 2018/11/06 英語 研究論文(学術雑誌) 公開
Shintaro Yamada, Kazuto Kugou, Da-Qiao Ding, Yurika Fujita, Yasushi Hiraoka, Hiroshi Murakami, Kunihiro Ohta, Takatomi Yamada Shintaro Yamada, Kazuto Kugou, Da-Qiao Ding, Yurika Fujita, Yasushi Hiraoka, Hiroshi Murakami, Kunihiro Ohta, Takatomi Yamada Shintaro Yamada, Kazuto Kugou, Da-Qiao Ding, Yurika Fujita, Yasushi Hiraoka, Hiroshi Murakami, Kunihiro Ohta, Takatomi Yamada The conserved histone variant H2A.Z illuminates meiotic recombination initiation. The conserved histone variant H2A.Z illuminates meiotic recombination initiation. The conserved histone variant H2A.Z illuminates meiotic recombination initiation. Current genetics, 64, 5, 1015-1019 Current genetics, 64, 5, 1015-1019 Current genetics, 64, 5, 1015-1019 2018/10 英語 研究論文(学術雑誌) 公開
Shintaro Yamada, Kazuto Kugou, Da-Qiao Ding, Yurika Fujita, Yasushi Hiraoka, Hiroshi Murakami, Kunihiro Ohta, Takatomi Yamada Shintaro Yamada, Kazuto Kugou, Da-Qiao Ding, Yurika Fujita, Yasushi Hiraoka, Hiroshi Murakami, Kunihiro Ohta, Takatomi Yamada Shintaro Yamada, Kazuto Kugou, Da-Qiao Ding, Yurika Fujita, Yasushi Hiraoka, Hiroshi Murakami, Kunihiro Ohta, Takatomi Yamada The histone variant H2A.Z promotes initiation of meiotic recombination in fission yeast. The histone variant H2A.Z promotes initiation of meiotic recombination in fission yeast. The histone variant H2A.Z promotes initiation of meiotic recombination in fission yeast. Nucleic acids research, 46, 2, 609-620 Nucleic acids research, 46, 2, 609-620 Nucleic acids research, 46, 2, 609-620 2018/01/25 英語 研究論文(学術雑誌) 公開
Shintaro Yamada, Seoyoung Kim, Sam E Tischfield, Maria Jasin, Julian Lange, Scott Keeney Shintaro Yamada, Seoyoung Kim, Sam E Tischfield, Maria Jasin, Julian Lange, Scott Keeney Shintaro Yamada, Seoyoung Kim, Sam E Tischfield, Maria Jasin, Julian Lange, Scott Keeney Genomic and chromatin features shaping meiotic double-strand break formation and repair in mice. Genomic and chromatin features shaping meiotic double-strand break formation and repair in mice. Genomic and chromatin features shaping meiotic double-strand break formation and repair in mice. Cell cycle (Georgetown, Tex.), 16, 20, 1870-1884 Cell cycle (Georgetown, Tex.), 16, 20, 1870-1884 Cell cycle (Georgetown, Tex.), 16, 20, 1870-1884 2017/10/18 英語 研究論文(学術雑誌) 公開
Shintaro Yamada, Mika Okamura, Arisa Oda, Hiroshi Murakami, Kunihiro Ohta, Takatomi Yamada Shintaro Yamada, Mika Okamura, Arisa Oda, Hiroshi Murakami, Kunihiro Ohta, Takatomi Yamada Shintaro Yamada, Mika Okamura, Arisa Oda, Hiroshi Murakami, Kunihiro Ohta, Takatomi Yamada Correlation of Meiotic DSB Formation and Transcription Initiation Around Fission Yeast Recombination Hotspots. Correlation of Meiotic DSB Formation and Transcription Initiation Around Fission Yeast Recombination Hotspots. Correlation of Meiotic DSB Formation and Transcription Initiation Around Fission Yeast Recombination Hotspots. Genetics, 206, 2, 801-809 Genetics, 206, 2, 801-809 Genetics, 206, 2, 801-809 2017/06 英語 研究論文(学術雑誌) 公開
Eleni P Mimitou, Shintaro Yamada, Scott Keeney Eleni P Mimitou, Shintaro Yamada, Scott Keeney Eleni P Mimitou, Shintaro Yamada, Scott Keeney A global view of meiotic double-strand break end resection. A global view of meiotic double-strand break end resection. A global view of meiotic double-strand break end resection. Science (New York, N.Y.), 355, 6320, 40-45 Science (New York, N.Y.), 355, 6320, 40-45 Science (New York, N.Y.), 355, 6320, 40-45 2017/01/06 英語 研究論文(学術雑誌) 公開
Julian Lange, Shintaro Yamada, Sam E Tischfield, Jing Pan, Seoyoung Kim, Xuan Zhu, Nicholas D Socci, Maria Jasin, Scott Keeney Julian Lange, Shintaro Yamada, Sam E Tischfield, Jing Pan, Seoyoung Kim, Xuan Zhu, Nicholas D Socci, Maria Jasin, Scott Keeney Julian Lange, Shintaro Yamada, Sam E Tischfield, Jing Pan, Seoyoung Kim, Xuan Zhu, Nicholas D Socci, Maria Jasin, Scott Keeney The Landscape of Mouse Meiotic Double-Strand Break Formation, Processing, and Repair. The Landscape of Mouse Meiotic Double-Strand Break Formation, Processing, and Repair. The Landscape of Mouse Meiotic Double-Strand Break Formation, Processing, and Repair. Cell, 167, 3, 695-708 Cell, 167, 3, 695-708 Cell, 167, 3, 695-708 2016/10/20 英語 研究論文(学術雑誌) 公開
Shintaro Yamada, Kunihiro Ohta, Takatomi Yamada Shintaro Yamada, Kunihiro Ohta, Takatomi Yamada Shintaro Yamada, Kunihiro Ohta, Takatomi Yamada Acetylated Histone H3K9 is associated with meiotic recombination hotspots, and plays a role in recombination redundantly with other factors including the H3K4 methylase Set1 in fission yeast. Acetylated Histone H3K9 is associated with meiotic recombination hotspots, and plays a role in recombination redundantly with other factors including the H3K4 methylase Set1 in fission yeast. Acetylated Histone H3K9 is associated with meiotic recombination hotspots, and plays a role in recombination redundantly with other factors including the H3K4 methylase Set1 in fission yeast. Nucleic acids research, 41, 6, 3504-17 Nucleic acids research, 41, 6, 3504-17 Nucleic acids research, 41, 6, 3504-17 2013/04/01 英語 研究論文(学術雑誌) 公開
Tomoichiro Miyoshi, Masaru Ito, Kazuto Kugou, Shintaro Yamada, Masaki Furuichi, Arisa Oda, Takatomi Yamada, Kouji Hirota, Hisao Masai, Kunihiro Ohta Tomoichiro Miyoshi, Masaru Ito, Kazuto Kugou, Shintaro Yamada, Masaki Furuichi, Arisa Oda, Takatomi Yamada, Kouji Hirota, Hisao Masai, Kunihiro Ohta Tomoichiro Miyoshi, Masaru Ito, Kazuto Kugou, Shintaro Yamada, Masaki Furuichi, Arisa Oda, Takatomi Yamada, Kouji Hirota, Hisao Masai, Kunihiro Ohta A central coupler for recombination initiation linking chromosome architecture to S phase checkpoint. A central coupler for recombination initiation linking chromosome architecture to S phase checkpoint. A central coupler for recombination initiation linking chromosome architecture to S phase checkpoint. Molecular cell, 47, 5, 722-33 Molecular cell, 47, 5, 722-33 Molecular cell, 47, 5, 722-33 2012/09/14 英語 研究論文(学術雑誌) 公開
Tomohiko Morita, Takatomi Yamada, Shintaro Yamada, Kouji Matsumoto, Kunihiro Ohta Tomohiko Morita, Takatomi Yamada, Shintaro Yamada, Kouji Matsumoto, Kunihiro Ohta Tomohiko Morita, Takatomi Yamada, Shintaro Yamada, Kouji Matsumoto, Kunihiro Ohta Fission yeast ATF/CREB family protein Atf21 plays important roles in production of normal spores. Fission yeast ATF/CREB family protein Atf21 plays important roles in production of normal spores. Fission yeast ATF/CREB family protein Atf21 plays important roles in production of normal spores. Genes to cells : devoted to molecular & cellular mechanisms, 16, 2, 217-30 Genes to cells : devoted to molecular & cellular mechanisms, 16, 2, 217-30 Genes to cells : devoted to molecular & cellular mechanisms, 16, 2, 217-30 2011/02 英語 研究論文(学術雑誌) 公開
Kazuto Kugou, Tomoyuki Fukuda, Shintaro Yamada, Masaru Ito, Hiroyuki Sasanuma, Saori Mori, Yuki Katou, Takehiko Itoh, Kouji Matsumoto, Takehiko Shibata, Katsuhiko Shirahige, Kunihiro Ohta Kazuto Kugou, Tomoyuki Fukuda, Shintaro Yamada, Masaru Ito, Hiroyuki Sasanuma, Saori Mori, Yuki Katou, Takehiko Itoh, Kouji Matsumoto, Takehiko Shibata, Katsuhiko Shirahige, Kunihiro Ohta Kazuto Kugou, Tomoyuki Fukuda, Shintaro Yamada, Masaru Ito, Hiroyuki Sasanuma, Saori Mori, Yuki Katou, Takehiko Itoh, Kouji Matsumoto, Takehiko Shibata, Katsuhiko Shirahige, Kunihiro Ohta Rec8 guides canonical Spo11 distribution along yeast meiotic chromosomes. Rec8 guides canonical Spo11 distribution along yeast meiotic chromosomes. Rec8 guides canonical Spo11 distribution along yeast meiotic chromosomes. Molecular biology of the cell, 20, 13, 3064-76 Molecular biology of the cell, 20, 13, 3064-76 Molecular biology of the cell, 20, 13, 3064-76 2009/07 英語 研究論文(学術雑誌) 公開

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タイトル言語:
Misc
著者 著者(日本語) 著者(英語) タイトル タイトル(日本語) タイトル(英語) 書誌情報等 書誌情報等(日本語) 書誌情報等(英語) 出版年月 査読の有無 記述言語 掲載種別 公開
Kazuto Kugou, Masaru Ito, Tomoyuki Fukuda, Shintaro Yamada, Takehiko Shibata, Katsuhiko Shirahige, Kunihiro Ohta Kazuto Kugou, Masaru Ito, Tomoyuki Fukuda, Shintaro Yamada, Takehiko Shibata, Katsuhiko Shirahige, Kunihiro Ohta Kazuto Kugou, Masaru Ito, Tomoyuki Fukuda, Shintaro Yamada, Takehiko Shibata, Katsuhiko Shirahige, Kunihiro Ohta Relationship between meiotic cohesin component Rec8 and DSB proteins Relationship between meiotic cohesin component Rec8 and DSB proteins Relationship between meiotic cohesin component Rec8 and DSB proteins GENES & GENETIC SYSTEMS, 85, 6, 416-416 GENES & GENETIC SYSTEMS, 85, 6, 416-416 GENES & GENETIC SYSTEMS, 85, 6, 416-416 2010/12 英語 研究発表要旨(国際会議) 公開
タイトル言語:
講演・口頭発表等
タイトル タイトル(日本語) タイトル(英語) 会議名 会議名(日本語) 会議名(英語) 主催者 主催者(日本語) 主催者(英語) 開催年月日 記述言語 会議種別 公開
マウスの減数分裂期のDNA二重鎖切断は反復配列で起こりにくいものの、それでも頻繁に起こっている[招待あり] マウスの減数分裂期のDNA二重鎖切断は反復配列で起こりにくいものの、それでも頻繁に起こっている [招待あり] Mouse meiotic double-strand breaks are underrepresented but nonetheless occur frequently within repeated sequences [招待あり] NYU 反復配列シンポジウム 2017 NYU 反復配列シンポジウム 2017 The 2017 NYU Repetitive DNA Symposium 2017/10/27 英語 シンポジウム・ワークショップパネル(公募) 公開
タイトル言語:
学術賞等
賞の名称(日本語) 賞の名称(英語) 授与組織名(日本語) 授与組織名(英語) 年月
東京大学理学部学生選抜国際派遣プログラム The University of Tokyo Faculty of Science, Elite Science Student Visit Abroad Program 東京大学理学部 The University of Tokyo Faculty of Science 2008/03/31
東京大学理学部生物情報科学学部教育特別プログラム The University of Tokyo Faculty of Science, Undergraduate Program for Bioinformatics and Systems Biology 東京大学理学部 The University of Tokyo Faculty of Science 2007/03/31
日本学術振興会特別研究員DC1 Research Fellowship for Young Scientists from the Japan Society for the Promotion of Science 日本学術振興会 the Japan Society for the Promotion of Science 2010/04/01
村瀬九郎医師JMSA奨学金 Kuro Murase MD-JMSA Scholarship 米国日本人医師会 Japanese Medical Society of America 2015/05/09
第10回3Rシンポジウムベストポスター賞 The 10th 3R Symposium Best Poster Award 第10回3Rシンポジウム The 10th 3R Symposium 2016/11/16
外部資金:競争的資金 (科学研究費補助金)
種別 代表/分担 テーマ(日本語) テーマ(英語) 期間
若手研究 代表 放射線等で生じる、異常な付加体が付くゲノム切断端から付加体を除去する機序の解明 (2019年度分) 2019/04/01〜2020/03/31