植田 和光

最終更新日時: 2016/07/22 09:29:28

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氏名(漢字/フリガナ/アルファベット表記)
植田 和光/ウエダ カズミツ/Kazumitsu Ueda
所属部署・職名(部局/所属/講座等/職名)
農学研究科/応用生命科学専攻応用生化学講座/教授
学部兼担
部局 所属 講座等 職名
農学部
学内兼務
部局 所属 講座等 職名
農学研究科 応用生命科学専攻 応用生化学講座 協力教員(教授)
連絡先住所
種別 住所(日本語) 住所(英語)
職場 606-8502 京都府京都市左京区北白川 Laboratory of Cellular Biochemistry,Division of Applied Life Sciences,Graduate School of Agriculture, Kyoto University,Kitasirakawa, Sakyo-ku,Kyoto 606-8502, Japan
連絡先電話番号
種別 番号
職場 075-753-6124
所属学会(国内)
学会名(日本語) 学会名(英語)
日本農芸化学会
日本生化学会
日本分子生物学会
取得学位
学位名(日本語) 学位名(英語) 大学(日本語) 大学(英語) 取得区分
農学修士 京都大学
農学博士 京都大学
出身大学院・研究科等
大学名(日本語) 大学名(英語) 研究科名(日本語) 研究科名(英語) 専攻名(日本語) 専攻名(英語) 修了区分
京都大学 大学院農学研究科修士課程 修了
出身学校・専攻等
大学名(日本語) 大学名(英語) 学部名(日本語) 学部名(英語) 学科名(日本語) 学科名(英語) 卒業区分
京都大学 農学部農芸化学科 卒業
職歴
期間 組織名(日本語) 組織名(英語) 職名(日本語) 職名(英語)
研究テーマ
(日本語)
ABC蛋白質の分子メカニズムの解明 HDL産生機構の解明
(英語)
Molecular mechanism of ABC proteins Mechanism of HDL formation
研究概要
(日本語)
私たちの身体は、約60兆個の細胞でできています。それらのうち、数千億個の細胞が毎日死に、新しい細胞に置き換わっています。つまり、私たちの身体の細胞は、半年もするとほぼすべて新しい細胞に置き換わるのです。それらの新しい細胞は、私たちが毎日食べている食物中の肉や穀物に含まれているアミノ酸、糖類や脂質をもとにして作られます。肉や穀物は消化されたのち、アミノ酸、糖、脂質として小腸から吸収され、肝臓に運ばれた後、全身の細胞へと血流に乗って運ばれ私たちの身体となります。私たちが健康を保つためには、吸収された栄養素が全身の細胞へと運ばれる仕組みがきちんと働く必要があります。 脂質のひとつであるコレステロールは、一般に悪者のように言われますが、実は細胞を作る上で非常に重要な栄養素のひとつです。しかし、コレステロールが過剰にたまると細胞が死んでしまうため、悪者のように言われています。コレステロールを過剰にため込んだ細胞が動脈壁に沈着し血液が流れにくくなる動脈硬化は、先進国の死因の約4分の1を占めるのです。 全身の細胞で過剰になったコレステロールは、善玉コレステロールと呼ばれるHDL粒子として血流を介して肝臓へ戻されます。一方、悪玉コレステロールLDLは、肝臓から全身の細胞へコレステロールを届けるためにあります。どちらも体にとっては必要なものですが、LDLが多いと動脈硬化になりやすいため、悪玉と呼ばれます。 私たちは、HDLが産生されるメカニズムを研究しています。私たちは、脂溶性物質が体の中で運ばれる仕組みを30年前に世界で初めて明らかにしました。それ以来、脂溶性物質やコレステロールが運ばれる仕組みを研究しています。HDLが多い人は動脈硬化になりにくいことがわかっています。私たちの研究でHDLの産生機構が明らかになれば、動脈硬化を予防できると期待されます。
(英語)
Our body is made of 60 trillion cells and hundreds of billions of the cells die and are renewed with fresh ones every day. The fresh cells are constructed by using amino acids, carbohydrates and lipids contained in daily diet. Meat, grains and other food are digested, and the nutrients are absorbed from intestine. They are first delivered to liver and then transported to all the body cells to be used as materials for the cells. To maintain our life and health, absorbed nutrients should be transported properly via bloodstream to all the body cells. Cholesterol, one of lipids, is also a very important nutrient to construct cells. However, it has a bad reputation, because its over-accumulation destroys cells. Buildup of dead cells, in which cholesterol is over-accumulated, in artery wall hampers blood flow and causes atherosclerosis. Cholesterol is delivered from liver to all the body cells through bloodstream as LDL particles, so-called bad cholesterol, and excess cholesterol in body cells are reversely transported to liver through bloodstream as HDL particles, so-called good cholesterol. While both LDL and HDL particles are necessary for us, people with high LDL in blood have high risk of atherosclerosis. It is why LDL particles are called bad cholesterol. 30 years ago, we discovered the mechanism by which lipophilic compounds are transported in our body for the first time. When our body has some defects in transporting lipophilic compounds including cholesterol, we suffer from various diseases, such as atherosclerosis, Alzheimer’s disease, skin diseases, eye diseases. Ueda group is trying to reveal the mechanism of lipid transport and HDL generation and to find ways to prevent and cure various diseases which trouble us.
研究分野(キーワード)
キーワード(日本語) キーワード(英語)
農芸化学,脂質生化学, 分子細胞生物学 Lipid biochemistry, Molecular Cell Biology, Agricultural Chemistry
研究分野(科研費分類コード)
科研費分類コード
応用生物化学
細胞生物学
情報学基礎
論文
著者 著者(日本語) 著者(英語) タイトル タイトル(日本語) タイトル(英語) 書誌情報等 出版年月 査読の有無 記述言語 掲載種別 公開
Nakato M, Matsuo M, Kono N, Arita M, Arai H, Ogawa J, Kioka N, Ueda K Nakato M, Matsuo M, Kono N, Arita M, Arai H, Ogawa J, Kioka N, Ueda K Nakato M, Matsuo M, Kono N, Arita M, Arai H, Ogawa J, Kioka N, Ueda K Neurite outgrowth stimulation by n3 and n6 polyunsaturated fatty acids of phospholipids in apolipoprotein E containing lipoproteins secreted from glial cells. Neurite outgrowth stimulation by n3 and n6 polyunsaturated fatty acids of phospholipids in apolipoprotein E containing lipoproteins secreted from glial cells. Neurite outgrowth stimulation by n3 and n6 polyunsaturated fatty acids of phospholipids in apolipoprotein E containing lipoproteins secreted from glial cells. Journal of lipid research 2015/08 公開
Yamauchi Y, Iwamoto N, Rogers MA, Abe-Dohmae S, Fujimoto T, Chang CC, Ishigami M, Kishimoto T, Kobayashi T, Ueda K, Furukawa K, Chang TY, Yokoyama S Yamauchi Y, Iwamoto N, Rogers MA, Abe-Dohmae S, Fujimoto T, Chang CC, Ishigami M, Kishimoto T, Kobayashi T, Ueda K, Furukawa K, Chang TY, Yokoyama S Yamauchi Y, Iwamoto N, Rogers MA, Abe-Dohmae S, Fujimoto T, Chang CC, Ishigami M, Kishimoto T, Kobayashi T, Ueda K, Furukawa K, Chang TY, Yokoyama S Deficiency in the lipid exporter ABCA1 impairs retrograde sterol movement and disrupts sterol sensing at the endoplasmic reticulum. Deficiency in the lipid exporter ABCA1 impairs retrograde sterol movement and disrupts sterol sensing at the endoplasmic reticulum. Deficiency in the lipid exporter ABCA1 impairs retrograde sterol movement and disrupts sterol sensing at the endoplasmic reticulum. The Journal of biological chemistry 2015/07 公開
Zhao Y, Ishigami M, Nagao K, Hanada K, Kono N, Arai H, Matsuo M, Kioka N, Ueda K Zhao Y, Ishigami M, Nagao K, Hanada K, Kono N, Arai H, Matsuo M, Kioka N, Ueda K Zhao Y, Ishigami M, Nagao K, Hanada K, Kono N, Arai H, Matsuo M, Kioka N, Ueda K ABCB4 exports phosphatidylcholine in a sphingomyelin-dependent manner. ABCB4 exports phosphatidylcholine in a sphingomyelin-dependent manner. ABCB4 exports phosphatidylcholine in a sphingomyelin-dependent manner. Journal of lipid research,56,3,644-652 2015/03 公開
Itoh S, Nagao K, Kimura Y, Matsuo M, Kioka N, Ueda K Itoh S, Nagao K, Kimura Y, Matsuo M, Kioka N, Ueda K Itoh S, Nagao K, Kimura Y, Matsuo M, Kioka N, Ueda K Position 834 in TM6 plays an important role in cholesterol and phosphatidylcholine transport by ABCA1. Position 834 in TM6 plays an important role in cholesterol and phosphatidylcholine transport by ABCA1. Position 834 in TM6 plays an important role in cholesterol and phosphatidylcholine transport by ABCA1. Bioscience, biotechnology, and biochemistry,79,5,775-781 2015 公開
Omura R, Nagao K, Kobayashi N, Ueda K, Saito H Omura R, Nagao K, Kobayashi N, Ueda K, Saito H Omura R, Nagao K, Kobayashi N, Ueda K, Saito H Direct detection of ABCA1-dependent HDL formation based on lipidation-induced hydrophobicity change in apoA-I. Direct detection of ABCA1-dependent HDL formation based on lipidation-induced hydrophobicity change in apoA-I. Direct detection of ABCA1-dependent HDL formation based on lipidation-induced hydrophobicity change in apoA-I. Journal of lipid research,55,11,2423-2431 2014/11 公開
Kuo TF, Mao D, Hirata N, Khambu B, Kimura Y, Kawase E, Shimogawa H, Ojika M, Nakatsuji N, Ueda K, Uesugi M Kuo TF, Mao D, Hirata N, Khambu B, Kimura Y, Kawase E, Shimogawa H, Ojika M, Nakatsuji N, Ueda K, Uesugi M Kuo TF, Mao D, Hirata N, Khambu B, Kimura Y, Kawase E, Shimogawa H, Ojika M, Nakatsuji N, Ueda K, Uesugi M Selective elimination of human pluripotent stem cells by a marine natural product derivative. Selective elimination of human pluripotent stem cells by a marine natural product derivative. Selective elimination of human pluripotent stem cells by a marine natural product derivative. Journal of the American Chemical Society,136,28,9798-9801 2014/07 公開
Hirata N, Nakagawa M, Fujibayashi Y, Yamauchi K, Murata A, Minami I, Tomioka M, Kondo T, Kuo TF, Endo H, Inoue H, Sato S, Ando S, Kawazoe Y, Aiba K, Nagata K, Kawase E, Chang YT, Suemori H, Eto K, Nakauchi H, Yamanaka S, Nakatsuji N, Ueda K, Uesugi M Hirata N, Nakagawa M, Fujibayashi Y, Yamauchi K, Murata A, Minami I, Tomioka M, Kondo T, Kuo TF, Endo H, Inoue H, Sato S, Ando S, Kawazoe Y, Aiba K, Nagata K, Kawase E, Chang YT, Suemori H, Eto K, Nakauchi H, Yamanaka S, Nakatsuji N, Ueda K, Uesugi M N. Hirata; M. Nakagawa; Y. Fujibayashi; K. Yamauchi; A. Murata; I. Minami; M. Tomioka; T. Kondo; T.-F. Kuo; H. Endo; H. Inoue; S.-I. Sato; S. Ando; Y. Kawazoe; K. Aiba; K. Nagata; E. Kawase; Y.-T. Chang; H. Suemori; K. Eto; H. Nakauchi; S. Yamanaka; N. Nakatsuji; K. Ueda; M. Uesugi A chemical probe that labels human pluripotent stem cells. A chemical probe that labels human pluripotent stem cells. A Chemical Probe that Labels Human Pluripotent Stem Cells Cell reports,6,6,1165-1174 2014/03 英語 公開
Chiba T, Sakurada T, Watanabe R, Yamaguchi K, Kimura Y, Kioka N, Kawagishi H, Matsuo M, Ueda K Chiba T, Sakurada T, Watanabe R, Yamaguchi K, Kimura Y, Kioka N, Kawagishi H, Matsuo M, Ueda K Chiba T, Sakurada T, Watanabe R, Yamaguchi K, Kimura Y, Kioka N, Kawagishi H, Matsuo M, Ueda K Fomiroid A, a novel compound from the mushroom fomitopsis nigra, inhibits NPC1L1-mediated cholesterol uptake via a mode of action distinct from that of ezetimibe. Fomiroid A, a novel compound from the mushroom fomitopsis nigra, inhibits NPC1L1-mediated cholesterol uptake via a mode of action distinct from that of ezetimibe. Fomiroid A, a novel compound from the mushroom fomitopsis nigra, inhibits NPC1L1-mediated cholesterol uptake via a mode of action distinct from that of ezetimibe. PloS one,9,12,e116162 2014 公開
Sano O, Ito S, Kato R, Shimizu Y, Kobayashi A, Kimura Y, Kioka N, Hanada K, Ueda K, Matsuo M Sano O, Ito S, Kato R, Shimizu Y, Kobayashi A, Kimura Y, Kioka N, Hanada K, Ueda K, Matsuo M Sano O, Ito S, Kato R, Shimizu Y, Kobayashi A, Kimura Y, Kioka N, Hanada K, Ueda K, Matsuo M ABCA1, ABCG1, and ABCG4 are distributed to distinct membrane meso-domains and disturb detergent-resistant domains on the plasma membrane. ABCA1, ABCG1, and ABCG4 are distributed to distinct membrane meso-domains and disturb detergent-resistant domains on the plasma membrane. ABCA1, ABCG1, and ABCG4 are distributed to distinct membrane meso-domains and disturb detergent-resistant domains on the plasma membrane. PloS one,9,10,e109886 2014 公開
K. Ueda; K. Takahashi; A. Kobayashi; M. Matsuo K. Ueda; K. Takahashi; A. Kobayashi; M. Matsuo ABC proteins move lipids ABC proteins move lipids Tanpakushitsu kakusan koso. Protein, nucleic acid, enzyme.,51,4,342-349 2006 日本語 公開
K. Ueda K. Ueda ABC proteins involved in lipid homeostasis ABC proteins involved in lipid homeostasis Seikagaku. The Journal of Japanese Biochemical Society,76,6,525-531 2004 日本語 公開
M. Matsuo; K. Ueda M. Matsuo; K. Ueda XYZ of ABC proteins?: where is the goal for the study of ABC protein structure? XYZ of ABC proteins?: where is the goal for the study of ABC protein structure? Tanpakushitsu kakusan koso. Protein, nucleic acid, enzyme,47,11,1431-1438 2002 日本語 公開
植田和光 植田和光 Molecular mechanism of multidrug transporter MDR 1: ABC in host-defense machinery. Molecular mechanism of multidrug transporter MDR 1: ABC in host-defense machinery. 蛋白質 核酸 酵素,46,5,588-595 2001/04/01 日本語 公開
植田 和光 植田 和光 分子メカニズムと生体防御機構における役割 分子メカニズムと生体防御機構における役割 バイオサイエンスとインダストリー = Bioscience & industry,58,1,24-27 2000/01/01 日本語 公開
植田 和光 植田 和光 ABCトランスポーター:医薬開発のターゲット ABCトランスポーター:医薬開発のターゲット バイオサイエンスとインダストリー,58/,23 2000 日本語 公開
植田 和光 植田 和光 環境有害物質に対する生物防御の分子メカニズム 環境有害物質に対する生物防御の分子メカニズム 農化,74/,791-794 2000 日本語 公開
K. Ueda; T. Amachi K. Ueda; T. Amachi Molecular mechanism of defence to toxic substance Molecular mechanism of defence to toxic substance Nippon Nogeikagaku Kaishi,74,7,791-794 2000 日本語 公開
植田 和光 植田 和光 アプローチ:ABCタンパク質の多機能性と生体防御. アプローチ:ABCタンパク質の多機能性と生体防御. 最新医学,54/,352-359 1999 日本語 公開
植田 和光 植田 和光 トランスポーター型ABCタンパク質P糖タンパク質 トランスポーター型ABCタンパク質P糖タンパク質 最新医学,54/,360-365 1999 日本語 公開
植田 和光 植田 和光 薬剤耐性の分子生物学的機序 薬剤耐性の分子生物学的機序 炎症と免疫,7/,114-120 1999 日本語 公開
植田 和光 植田 和光 MDR1/P-糖タンパク質の薬剤輸送の分子機構. MDR1/P-糖タンパク質の薬剤輸送の分子機構. 蛋白質核酸酵素,42/8,1263 1997 日本語 公開
植田 和光 植田 和光 抗癌剤に対する膜輸送機構の変化を介した耐性獲得. 抗癌剤に対する膜輸送機構の変化を介した耐性獲得. 日本臨床,55/5,1024 1997 日本語 公開
植田 和光 植田 和光 生体異物排出ポンプMDR1/P-糖タンパク質の分子機構. 生体異物排出ポンプMDR1/P-糖タンパク質の分子機構. 日本農芸化学会誌,71/8,785 1997 日本語 公開
植田 和光 植田 和光 生体異物排出ポンプP-糖蛋白質とMRPの構造と活性-分子標的としての重要性- 生体異物排出ポンプP-糖蛋白質とMRPの構造と活性-分子標的としての重要性- 癌と化学療法,/,24 1997 日本語 公開
K. Ueda K. Ueda Molecular mechanisms for drug transport by MDR1/P-glycoprotein Molecular mechanisms for drug transport by MDR1/P-glycoprotein Tanpakushitsu kakusan koso. Protein, nucleic acid, enzyme,42,8,1263-1272 1997 日本語 公開
K. Ueda K. Ueda MDR 1/P-glycoprotein : An efflux pump of lipophilic xenobiotics MDR 1/P-glycoprotein : An efflux pump of lipophilic xenobiotics Nippon Nogeikagaku Kaishi,71,8,785-788 1997 日本語 公開
植田和光 植田和光 Family and super family of gene and proteins. Membrane transporter. ATP binding cassette transporter super family. Family and super family of gene and proteins. Membrane transporter. ATP binding cassette transporter super family. 生体の科学,46,5,596-598 1995/09 日本語 公開
植田和光 植田和光 P glyco proteins and anticancer drug resistance. P glyco proteins and anticancer drug resistance. Bio Clin,9,14,1063-1067 1994/12 日本語 公開
植田和光;駒野徹 植田和光;駒野徹 Structure and function of multidrug resistance(MDR) gene. Structure and function of multidrug resistance(MDR) gene. 医学のあゆみ,167,3,147-149 1993/10/16 日本語 公開
植田 和光 植田 和光 [要修正] MDRI遺伝子の構造と機能 [要修正] MDRI遺伝子の構造と機能 ,30,688-695 1993 日本語 公開
植田 和光 植田 和光 P-糖蛋白質 P-糖蛋白質 廣川タンパク質化学第2巻受容体タンパク質II,2,453-459 1993 日本語 公開
植田 和光 植田 和光 Pー糖蛋白質の遺伝子と機能 Pー糖蛋白質の遺伝子と機能 ,/10,8-14 1993 日本語 公開
植田 和光 植田 和光 多剤耐性遺伝子MDR1 多剤耐性遺伝子MDR1 化学と生物,/30,410-411 1992 日本語 公開
植田 和光 植田 和光 癌の多剤耐性に関与するヒトPー糖蛋白質の機能の解析 癌の多剤耐性に関与するヒトPー糖蛋白質の機能の解析 日本農芸化学会誌,/66,1617-1624 1992 日本語 公開
植田 和光 植田 和光 抗癌剤を細胞外に排出するPー糖蛋白質の本来の基質は何か 抗癌剤を細胞外に排出するPー糖蛋白質の本来の基質は何か 化学,/46,428-429 1991 日本語 公開
植田 和光 植田 和光 MDR1とPー糖蛋白質 MDR1とPー糖蛋白質 ,/6,301-306 1990 日本語 公開
植田 和光 植田 和光 多剤耐性の分子機構 多剤耐性の分子機構 腫瘍と感染,/3,443-450 1990 日本語 公開
植田 和光 植田 和光 ヒト多剤耐性遺伝子を担うMDR1遺伝子の構造と機能 ヒト多剤耐性遺伝子を担うMDR1遺伝子の構造と機能 ファルマシア,/26,809-813 1990 日本語 公開
植田和光 植田和光 癌の多剤耐性はMDR1遺伝子が担っているのか? 癌の多剤耐性はMDR1遺伝子が担っているのか? 蛋白質 核酸 酵素,33,8,1287-1299 1988/07 日本語 公開
植田 和光 植田 和光 [要修正] 多剤耐性遺伝子MDR1. [要修正] 多剤耐性遺伝子MDR1. 癌と化学療法,/15,2858-2862 1988 日本語 公開
植田 和光 植田 和光 多剤耐性遺伝子MDR1とその発見機構 多剤耐性遺伝子MDR1とその発見機構 細胞工学,/9,96-104 1988 日本語 公開
A. Fojo; M. Cornwell; C. Cardarelli; D.P. Clark; N. Richert; D.-w. Shen; K. Ueda; M. Willingham; M.M. Gottesman; I. Pastan A. Fojo; M. Cornwell; C. Cardarelli; D.P. Clark; N. Richert; D.-w. Shen; K. Ueda; M. Willingham; M.M. Gottesman; I. Pastan [要修正] [要修正] Molecular biology of drug resistance ,9,1,5-16 1987 英語 公開
植田 和光 植田 和光 [要修正] [要修正] ATP binding/hydrolysis by and phosphorylation of peroxisomal ABC proteins PMP70 (ABCD3) and ALDP (ABCD1). J. Biol. Chem. 277, 40142-40147 英語 公開
Yamashita H, Ichikawa T, Matsuyama D, Kimura Y, Ueda K, Craig SW, Harada I, Kioka N Yamashita H, Ichikawa T, Matsuyama D, Kimura Y, Ueda K, Craig SW, Harada I, Kioka N The role of the interaction of the vinculin proline-rich linker region with vinexin α in sensing the stiffness of the extracellular matrix. The role of the interaction of the vinculin proline-rich linker region with vinexin α in sensing the stiffness of the extracellular matrix. ,127,Pt 9,1875-1886 2014/05 公開
A. Kodan; T. Yamaguchi; T. Nakatsu; K. Sakiyama; C.J. Hipolito; A. Fujioka; R. Hirokane; K. Ikeguchi; B. Watanabe; J. Hiratake; Y. Kimura; H. Suga; K. Ueda; H. Kato A. Kodan; T. Yamaguchi; T. Nakatsu; K. Sakiyama; C.J. Hipolito; A. Fujioka; R. Hirokane; K. Ikeguchi; B. Watanabe; J. Hiratake; Y. Kimura; H. Suga; K. Ueda; H. Kato Structural basis for gating mechanisms of a eukaryotic P-glycoprotein homolog Structural basis for gating mechanisms of a eukaryotic P-glycoprotein homolog ,111,11,4049-4054 2014 英語 公開
S. Kishino; M. Takeuchi; S.-B. Park; A. Hirata; N. Kitamura; J. Kunisawa; H. Kiyono; R. Iwamoto; Y. Isobe; M. Arita; H. Arai; K. Ueda; J. Shima; S. Takahashi; K. Yokozeki; S. Shimizu; J. Ogawa S. Kishino; M. Takeuchi; S.-B. Park; A. Hirata; N. Kitamura; J. Kunisawa; H. Kiyono; R. Iwamoto; Y. Isobe; M. Arita; H. Arai; K. Ueda; J. Shima; S. Takahashi; K. Yokozeki; S. Shimizu; J. Ogawa Polyunsaturated fatty acid saturation by gut lactic acid bacteria affecting host lipid composition Polyunsaturated fatty acid saturation by gut lactic acid bacteria affecting host lipid composition ,110,44,17808-17813 2013/10/29 英語 公開
A. Matsuda; K. Nagao; M. Matsuo; N. Kioka; K. Ueda A. Matsuda; K. Nagao; M. Matsuo; N. Kioka; K. Ueda 24(S)-hydroxycholesterol is actively eliminated from neuronal cells by ABCA1 24(S)-hydroxycholesterol is actively eliminated from neuronal cells by ABCA1 ,126,1,93-101 2013/07 英語 公開
N. Takemoto; T. Suehara; H.L. Frisco; S.-I. Sato; T. Sezaki; K. Kusamori; Y. Kawazoe; S.M. Park; S. Yamazoe; Y. Mizuhata; R. Inoue; G.J. Miller; S.U. Hansen; G.C. Jayson; J.M. Gardiner; T. Kanaya; N. Tokitoh; K. Ueda; Y. Takakura; N. Kioka; M. Nishikawa; M. Uesugi N. Takemoto; T. Suehara; H.L. Frisco; S.-I. Sato; T. Sezaki; K. Kusamori; Y. Kawazoe; S.M. Park; S. Yamazoe; Y. Mizuhata; R. Inoue; G.J. Miller; S.U. Hansen; G.C. Jayson; J.M. Gardiner; T. Kanaya; N. Tokitoh; K. Ueda; Y. Takakura; N. Kioka; M. Nishikawa; M. Uesugi Small-molecule-induced clustering of heparan sulfate promotes cell adhesion Small-molecule-induced clustering of heparan sulfate promotes cell adhesion ,135,30,11032-11039 2013/07 英語 公開
N. Shitan; F. Dalmas; K. Dan; N. Kato; K. Ueda; F. Sato; C. Forestier; K. Yazaki N. Shitan; F. Dalmas; K. Dan; N. Kato; K. Ueda; F. Sato; C. Forestier; K. Yazaki Characterization of Coptis japonica CjABCB2, an ATP-binding cassette protein involved in alkaloid transport Characterization of Coptis japonica CjABCB2, an ATP-binding cassette protein involved in alkaloid transport ,91,109-116 2013/07 英語 公開
T. Sezaki; L. Tomiyama; Y. Kimura; K. Ueda; N. Kioka T. Sezaki; L. Tomiyama; Y. Kimura; K. Ueda; N. Kioka Dlg5 interacts with the TGF-β receptor and promotes its degradation Dlg5 interacts with the TGF-β receptor and promotes its degradation ,587,11,1624-1629 2013/06 英語 公開
M. Ishigami; Y. Tominaga; K. Nagao; Y. Kimura; M. Matsuo; N. Kioka; K. Ueda M. Ishigami; Y. Tominaga; K. Nagao; Y. Kimura; M. Matsuo; N. Kioka; K. Ueda ATPase activity of nucleotide binding domains of human MDR3 in the context of MDR1 ATPase activity of nucleotide binding domains of human MDR3 in the context of MDR1 ,1831,4,683-690 2013/04 英語 公開
K.O. Nagata; C. Nakada; R.S. Kasai; A. Kusumi; K. Ueda K.O. Nagata; C. Nakada; R.S. Kasai; A. Kusumi; K. Ueda ABCA1 dimer-monomer interconversion during HDL generation revealed by single-molecule imaging ABCA1 dimer-monomer interconversion during HDL generation revealed by single-molecule imaging ,110,13,5034-5039 2013/03/26 英語 公開
K. Nagao; M. Maeda; N.B. Mañucat; K. Ueda K. Nagao; M. Maeda; N.B. Mañucat; K. Ueda Cyclosporine A and PSC833 inhibit ABCA1 function via direct binding Cyclosporine A and PSC833 inhibit ABCA1 function via direct binding ,1831,2,398-406 2013/02 英語 公開
H. Hirayama; Y. Kimura; N. Kioka; M. Matsuo; K. Ueda H. Hirayama; Y. Kimura; N. Kioka; M. Matsuo; K. Ueda ATPase activity of human ABCG1 is stimulated by cholesterol and sphingomyelin ATPase activity of human ABCG1 is stimulated by cholesterol and sphingomyelin ,54,2,496-502 2013/02 英語 公開
S. Kanaoka; Y. Kimura; M. Fujikawa; Y. Nakagawa; K. Ueda; M. Akamatsu S. Kanaoka; Y. Kimura; M. Fujikawa; Y. Nakagawa; K. Ueda; M. Akamatsu Substrate recognition by P-glycoprotein efflux transporters: Structure-ATPase activity relationship of diverse chemicals and agrochemicals Substrate recognition by P-glycoprotein efflux transporters: Structure-ATPase activity relationship of diverse chemicals and agrochemicals ,38,3,112-122 2013 英語 公開
M. Tomioka; Y. Toda; J. Kurisu; Y. Kimura; M. Kengaku; K. Ueda M. Tomioka; Y. Toda; J. Kurisu; Y. Kimura; M. Kengaku; K. Ueda The effects of neurological disorder-related codon variations of ABCA13 on the function of the ABC protein The effects of neurological disorder-related codon variations of ABCA13 on the function of the ABC protein ,76,12,2289-2293 2012/12 英語 公開
S. Hulpke; M. Tomioka; E. Kremmer; K. Ueda; R. Abele; R. Tampé S. Hulpke; M. Tomioka; E. Kremmer; K. Ueda; R. Abele; R. Tampé Direct evidence that the N-terminal extensions of the TAP complex act as autonomous interaction scaffolds for the assembly of the MHC i peptide-loading complex Direct evidence that the N-terminal extensions of the TAP complex act as autonomous interaction scaffolds for the assembly of the MHC i peptide-loading complex ,69,19,3317-3327 2012/10 英語 公開
T. Sezaki; K. Inada; T. Sogabe; K. Kakuda; L. Tomiyama; Y. Matsuno; T. Ichikawa; M. Matsuo; K. Ueda; N. Kioka T. Sezaki; K. Inada; T. Sogabe; K. Kakuda; L. Tomiyama; Y. Matsuno; T. Ichikawa; M. Matsuo; K. Ueda; N. Kioka Role of Dlg5/lp-dlg, a membrane-associated guanylate kinase family protein, in epithelial-mesenchymal transition in LLc-PK1 renal epithelial cells Role of Dlg5/lp-dlg, a membrane-associated guanylate kinase family protein, in epithelial-mesenchymal transition in LLc-PK1 renal epithelial cells ,7,4,e35519 2012/04/23 英語 公開
K. Nagao; Y. Kimura; K. Ueda K. Nagao; Y. Kimura; K. Ueda Lysine residues of ABCA1 are required for the interaction with apoA-I Lysine residues of ABCA1 are required for the interaction with apoA-I ,1821,3,530-535 2012/03 英語 公開
K. Nagao; K. Takahashi; Y. Azuma; M. Takada; Y. Kimura; M. Matsuo; N. Kioka; K. Ueda K. Nagao; K. Takahashi; Y. Azuma; M. Takada; Y. Kimura; M. Matsuo; N. Kioka; K. Ueda ATP hydrolysis-dependent conformational changes in the extracellular domain of ABCA1 are associated with apoA-I binding ATP hydrolysis-dependent conformational changes in the extracellular domain of ABCA1 are associated with apoA-I binding ,53,1,126-136 2012/01 英語 公開
K. Nagao; M. Tomioka; K. Ueda K. Nagao; M. Tomioka; K. Ueda Function and regulation of ABCA1 - Membrane meso-domain organization and reorganization Function and regulation of ABCA1 - Membrane meso-domain organization and reorganization ,278,18,3190-3203 2011/09 英語 公開
M. Hozoji-Inada; Y. Munehira; K. Nagao; N. Kioka; K. Ueda M. Hozoji-Inada; Y. Munehira; K. Nagao; N. Kioka; K. Ueda Liver X receptor β (LXRβ) interacts directly with ATP-binding cassette A1 (ABCA1) to promote high density lipoprotein formation during acute cholesterol accumulation Liver X receptor β (LXRβ) interacts directly with ATP-binding cassette A1 (ABCA1) to promote high density lipoprotein formation during acute cholesterol accumulation ,286,22,20117-20124 2011/06 英語 公開
H. Yamashita; K. Ueda; N. Kioka H. Yamashita; K. Ueda; N. Kioka WAVE2 forms a complex with PKA and is involved in PKA enhancement of membrane protrusions WAVE2 forms a complex with PKA and is involved in PKA enhancement of membrane protrusions ,286,5,3907-3914 2011/02/04 英語 公開
M. Matsuo; R.B. Campenot; D.E. Vance; K. Ueda; J.E. Vance M. Matsuo; R.B. Campenot; D.E. Vance; K. Ueda; J.E. Vance Involvement of low-density lipoprotein receptor-related protein and ABCG1 in stimulation of axonal extension by apoE-containing lipoproteins Involvement of low-density lipoprotein receptor-related protein and ABCG1 in stimulation of axonal extension by apoE-containing lipoproteins ,1811,1,31-38 2011/01 英語 公開
K. Ueda K. Ueda ABC proteins protect the human body and maintain optimal health ABC proteins protect the human body and maintain optimal health ,75,3,401-409 2011 英語 公開
Yamashita H., Ueda K., Kioka N. Yamashita H., Ueda K., Kioka N. WAVE2 forms a complex with cAMP-dependent protein kinase (PKA) and is involved in PKA enhancement of membrane protrusions. WAVE2 forms a complex with cAMP-dependent protein kinase (PKA) and is involved in PKA enhancement of membrane protrusions. 2011 英語 公開
Hozoji-Inada M., Munehira Y., Nagao K., Kioka N., Ueda K. Hozoji-Inada M., Munehira Y., Nagao K., Kioka N., Ueda K. LXR directly interacts with ABCA1 to promote HDL formation during acute cholesterol accumulation. LXR directly interacts with ABCA1 to promote HDL formation during acute cholesterol accumulation. 2011 英語 公開
K. Nagao; Y. Kimura; M. Mastuo; K. Ueda K. Nagao; Y. Kimura; M. Mastuo; K. Ueda Lipid outward translocation by ABC proteins Lipid outward translocation by ABC proteins ,584,13,2717-2723 2010/07/02 英語 公開
N. Kioka; T. Ito; H. Yamashita; N. Uekawa; T. Umemoto; S. Motoyoshi; H. Imai; K. Takahashi; H. Watanabe; M. Yamada; K. Ueda N. Kioka; T. Ito; H. Yamashita; N. Uekawa; T. Umemoto; S. Motoyoshi; H. Imai; K. Takahashi; H. Watanabe; M. Yamada; K. Ueda Crucial role of vinexin for keratinocyte migration in vitro and epidermal wound healing in vivo Crucial role of vinexin for keratinocyte migration in vitro and epidermal wound healing in vivo ,316,10,1728-1738 2010/06/10 英語 公開
M. Shichiri; Y. Takanezawa; D.E. Rotzoll; Y. Yoshida; T. Kokubu; K. Ueda; H. Tamai; H. Arai M. Shichiri; Y. Takanezawa; D.E. Rotzoll; Y. Yoshida; T. Kokubu; K. Ueda; H. Tamai; H. Arai ATP-Binding cassette transporter A1 is involved in hepatic α-tocopherol secretion ATP-Binding cassette transporter A1 is involved in hepatic α-tocopherol secretion ,21,5,451-456 2010/05 英語 公開
K. Terakado; A. Kodan; H. Nakano; Y. Kimura; K. Ueda; T. Nakatsu; H. Kato K. Terakado; A. Kodan; H. Nakano; Y. Kimura; K. Ueda; T. Nakatsu; H. Kato Deleting two C-terminal α-helices is effective to crystallize the bacterial ABC transporter Escherichia coli MsbA complexed with AMP-PNP Deleting two C-terminal α-helices is effective to crystallize the bacterial ABC transporter Escherichia coli MsbA complexed with AMP-PNP ,66,3,319-323 2010/03 英語 公開
T. Umemoto; K. Tanaka; K. Ueda; N. Kioka T. Umemoto; K. Tanaka; K. Ueda; N. Kioka Tyrosine phosphorylation of vinexin in v-Src-transformed cells attenuates the affinity for vinculin Tyrosine phosphorylation of vinexin in v-Src-transformed cells attenuates the affinity for vinculin ,387,1,191-195 2009/09/11 英語 公開
T. Sato; A. Kodan; Y. Kimura; K. Ueda; T. Nakatsu; H. Kato T. Sato; A. Kodan; Y. Kimura; K. Ueda; T. Nakatsu; H. Kato Functional role of the linker region in purified human P-glycoprotein Functional role of the linker region in purified human P-glycoprotein ,276,13,3504-3516 2009/07 英語 公開
T. Saeki; S. Mizushima; K. Ueda; K. Iwami; R. Kanamoto T. Saeki; S. Mizushima; K. Ueda; K. Iwami; R. Kanamoto Mutational analysis of uncharged polar residues and proline in the distal one-third (Thr<sup>130</sup>-Pro<sup>142</sup>) of the highly conserved region of mouse Slc10a2 Mutational analysis of uncharged polar residues and proline in the distal one-third (Thr<sup>130</sup>-Pro<sup>142</sup>) of the highly conserved region of mouse Slc10a2 ,73,7,1535-1540 2009/07 英語 公開
A. Kodan; H. Shibata; T. Matsumoto; K. Terakado; K. Sakiyama; M. Matsuo; K. Ueda; H. Kato A. Kodan; H. Shibata; T. Matsumoto; K. Terakado; K. Sakiyama; M. Matsuo; K. Ueda; H. Kato Improved expression and purification of human multidrug resistance protein MDR1 from baculovirus-infected insect cells Improved expression and purification of human multidrug resistance protein MDR1 from baculovirus-infected insect cells ,66,1,7-14 2009/07 英語 公開
T. Umemoto; T. Inomoto; K. Ueda; M. Hamaguchi; N. Kioka T. Umemoto; T. Inomoto; K. Ueda; M. Hamaguchi; N. Kioka v-Src-mediated transformation suppresses the expression of focal adhesion protein vinexin v-Src-mediated transformation suppresses the expression of focal adhesion protein vinexin ,279,1,22-29 2009/06/28 英語 公開
K. Nagao; Y. Zhao; K. Takahashi; Y. Kimura; K. Ueda K. Nagao; Y. Zhao; K. Takahashi; Y. Kimura; K. Ueda Sodium taurocholate-dependent lipid efflux by ABCA1: Effects of W590S mutation on lipid translocation and apolipoprotein A-I dissociation Sodium taurocholate-dependent lipid efflux by ABCA1: Effects of W590S mutation on lipid translocation and apolipoprotein A-I dissociation ,50,6,1165-1172 2009/06 英語 公開
Y. Azuma; M. Takada; M. Maeda; N. Kioka; K. Ueda Y. Azuma; M. Takada; M. Maeda; N. Kioka; K. Ueda The COP9 signalosome controls ubiquitinylation of ABCA1 The COP9 signalosome controls ubiquitinylation of ABCA1 ,382,1,145-148 2009/04/24 英語 公開
M. Hozoji; Y. Kimura; N. Kioka; K. Ueda M. Hozoji; Y. Kimura; N. Kioka; K. Ueda Formation of two intramolecular disulfide bonds is necessary for apoA-I-dependent cholesterol efflux mediated by ABCA1 Formation of two intramolecular disulfide bonds is necessary for apoA-I-dependent cholesterol efflux mediated by ABCA1 ,284,17,11293-11300 2009/04/24 英語 公開
T. Hirata; M. Okabe; A. Kobayashi; K. Ueda; M. Matsuo T. Hirata; M. Okabe; A. Kobayashi; K. Ueda; M. Matsuo Molecular mechanisms of subcellular localization of ABCG5 and ABCG8 Molecular mechanisms of subcellular localization of ABCG5 and ABCG8 ,73,3,619-626 2009/03 英語 公開
Y. Azuma; M. Takada; H.-W. Shin; N. Kioka; K. Nakayama; K. Ueda Y. Azuma; M. Takada; H.-W. Shin; N. Kioka; K. Nakayama; K. Ueda Retroendocytosis pathway of ABCA1/apoA-I contributes to HDL formation Retroendocytosis pathway of ABCA1/apoA-I contributes to HDL formation ,14,2,191-204 2009/02 英語 公開
M. Maekawa; J. Kikuchi; K. Kotani; K. Nagao; T. Odgerel; K. Ueda; M. Kawano; Y. Furukawa; I. Sakurabayashi M. Maekawa; J. Kikuchi; K. Kotani; K. Nagao; T. Odgerel; K. Ueda; M. Kawano; Y. Furukawa; I. Sakurabayashi A novel missense mutation of ABCA1 in transmembrane α-helix in a Japanese patient with Tangier disease A novel missense mutation of ABCA1 in transmembrane α-helix in a Japanese patient with Tangier disease ,206,1,216-222 2009 英語 公開
S.-Y. Morita; K. Ueda; S. Kitagawa S.-Y. Morita; K. Ueda; S. Kitagawa Enzymatic measurement of phosphatidic acid in cultured cells Enzymatic measurement of phosphatidic acid in cultured cells ,50,9,1945-1952 2009 英語 公開
S.-i. Akanuma; S. Ohtsuki; Y. Doi; M. Tachikawa; S. Ito; S. Hori; T. Asashima; T. Hashimoto; K. Yamada; K. Ueda; T. Iwatsubo; T. Terasaki S.-i. Akanuma; S. Ohtsuki; Y. Doi; M. Tachikawa; S. Ito; S. Hori; T. Asashima; T. Hashimoto; K. Yamada; K. Ueda; T. Iwatsubo; T. Terasaki ATP-binding cassette transporter A1 (ABCA1) deficiency does not attenuate the brain-to-blood efflux transport of human amyloid-β peptide (1-40) at the blood-brain barrier ATP-binding cassette transporter A1 (ABCA1) deficiency does not attenuate the brain-to-blood efflux transport of human amyloid-β peptide (1-40) at the blood-brain barrier ,52,6,956-961 2008 英語 公開
A.R. Tanaka; F. Kano; K. Ueda; M. Murata A.R. Tanaka; F. Kano; K. Ueda; M. Murata The ABCA1 Q597R mutant undergoes trafficking from the ER upon ER stress The ABCA1 Q597R mutant undergoes trafficking from the ER upon ER stress ,369,4,1174-1178 2008 英語 公開
A.R. Tanaka; F. Kano; A. Yamamoto; K. Ueda; M. Murata A.R. Tanaka; F. Kano; A. Yamamoto; K. Ueda; M. Murata Formation of cholesterol-enriched structures by aberrant intracellular accumulation of ATP-binding cassette transporter A1 Formation of cholesterol-enriched structures by aberrant intracellular accumulation of ATP-binding cassette transporter A1 ,13,8,889-904 2008 英語 公開
Hozoi M., Munehira Y., Ikeda Y., Makishima M., Matsuo M., Koika N., Ueda K. Hozoi M., Munehira Y., Ikeda Y., Makishima M., Matsuo M., Koika N., Ueda K. Direct interaction of nuclear receptor LXRβ with ABCA1 modulates cholesterol efflux. Direct interaction of nuclear receptor LXRβ with ABCA1 modulates cholesterol efflux. 2008 英語 公開
Y. Kimura; A. Kodan; M. Matsuo; K. Ueda Y. Kimura; A. Kodan; M. Matsuo; K. Ueda Cholesterol fill-in model: Mechanism for substrate recognition by ABC proteins Cholesterol fill-in model: Mechanism for substrate recognition by ABC proteins ,39,5-6,447-452 2007/12 英語 公開
K. Yasuhisa; M. Shin-ya; M. Michinori; U. Kazumitsu K. Yasuhisa; M. Shin-ya; M. Michinori; U. Kazumitsu Mechanism of multidrug recognition by MDR1/ABCB1 Mechanism of multidrug recognition by MDR1/ABCB1 ,98,9,1303-1310 2007/09 英語 公開
Y. Kimura; N. Kioka; H. Kato; M. Matsuo; K. Ueda Y. Kimura; N. Kioka; H. Kato; M. Matsuo; K. Ueda Modulation of drug-stimulated ATPase activity of human MDR1/P-glycoprotein by cholesterol Modulation of drug-stimulated ATPase activity of human MDR1/P-glycoprotein by cholesterol ,401,597-605 2007/01/15 英語 公開
N. Shitan; M. Tanaka; K. Terai; K. Ueda; K. Yazaki N. Shitan; M. Tanaka; K. Terai; K. Ueda; K. Yazaki Human MDR1 and MRP1 recognize berberine as their transport substrate Human MDR1 and MRP1 recognize berberine as their transport substrate ,71,1,242-245 2007/01 英語 公開
M. Mitsushima; K. Ueda; N. Kioka M. Mitsushima; K. Ueda; N. Kioka Involvement of phosphatases in the anchorage-dependent regulation of ERK2 activation Involvement of phosphatases in the anchorage-dependent regulation of ERK2 activation ,313,9,1830-1838 2007 英語 公開
K. Nagao; K. Takahashi; K. Hanada; N. Kioka; M. Matsuo; K. Ueda K. Nagao; K. Takahashi; K. Hanada; N. Kioka; M. Matsuo; K. Ueda Enhanced ApoA-I-dependent cholesterol efflux by ABCA1 from sphingomyelin-deficient Chinese hamster ovary cells Enhanced ApoA-I-dependent cholesterol efflux by ABCA1 from sphingomyelin-deficient Chinese hamster ovary cells ,282,20,14868-14874 2007 英語 公開
S.-Y. Morita; A. Kobayashi; Y. Takanezawa; N. Kioka; T. Handa; H. Arai; M. Matsuo; K. Ueda S.-Y. Morita; A. Kobayashi; Y. Takanezawa; N. Kioka; T. Handa; H. Arai; M. Matsuo; K. Ueda Bile salt-dependent efflux of cellular phospholipids mediated by ATP binding cassette protein B4 Bile salt-dependent efflux of cellular phospholipids mediated by ATP binding cassette protein B4 ,46,1,188-199 2007 英語 公開
O. Sano; A. Kobayashi; K. Nagao; K. Kumagai; N. Kioka; K. Hanada; K. Ueda; M. Matsuo O. Sano; A. Kobayashi; K. Nagao; K. Kumagai; N. Kioka; K. Hanada; K. Ueda; M. Matsuo Sphingomyelin-dependence of cholesterol efflux mediated by ABCG1 Sphingomyelin-dependence of cholesterol efflux mediated by ABCG1 ,48,11,2377-2384 2007 英語 公開
T. Saeki; Y. Munetaka; K. Ueda; K. Iwami; R. Kanamoto T. Saeki; Y. Munetaka; K. Ueda; K. Iwami; R. Kanamoto Effects of Ala substitution for conserved cys residues in mouse ileal and hepatic Na<sup>+</sup>-dependent bile acid transporters Effects of Ala substitution for conserved cys residues in mouse ileal and hepatic Na<sup>+</sup>-dependent bile acid transporters ,71,8,1865-1872 2007 英語 公開
S. Tachibana; M. Hirano; T. Hirata; M. Matsuo; I. Ikeda; K. Ueda; R. Sato S. Tachibana; M. Hirano; T. Hirata; M. Matsuo; I. Ikeda; K. Ueda; R. Sato Cholesterol and plant sterol efflux from cultured intestinal epithelial cells is mediated by ATP-binding cassette transporters Cholesterol and plant sterol efflux from cultured intestinal epithelial cells is mediated by ATP-binding cassette transporters ,71,8,1886-1895 2007 英語 公開
Y. Matsumura; N. Ban; K. Ueda; N. Inagaki Y. Matsumura; N. Ban; K. Ueda; N. Inagaki Characterization and classification of ATP-binding cassette transporter ABCA3 mutants in fatal surfactant deficiency Characterization and classification of ATP-binding cassette transporter ABCA3 mutants in fatal surfactant deficiency ,281,45,34503-34514 2006/11/10 英語 公開
K. Yazaki; N. Yamanaka; T. Masuno; S. Konagai; S. Kaneko; K. Ueda; F. Sato K. Yazaki; N. Yamanaka; T. Masuno; S. Konagai; S. Kaneko; K. Ueda; F. Sato Heterologous expression of a mammalian ABC transporter in plant and its application to phytoremediation Heterologous expression of a mammalian ABC transporter in plant and its application to phytoremediation ,61,3,491-503 2006/06 英語 公開
K. Takahashi; Y. Kimura; N. Kioka; M. Matsuo; K. Ueda K. Takahashi; Y. Kimura; N. Kioka; M. Matsuo; K. Ueda Purification and ATPase activity of human ABCA1 Purification and ATPase activity of human ABCA1 ,281,16,10760-10768 2006/04/21 英語 公開
K. Mutoh; J. Mitsuhashi; Y. Kimura; S. Tsukahara; E. Ishikawa; K. Sai; S. Ozawa; J.-I. Sawada; K. Ueda; K. Katayama; Y. Sugimoto K. Mutoh; J. Mitsuhashi; Y. Kimura; S. Tsukahara; E. Ishikawa; K. Sai; S. Ozawa; J.-I. Sawada; K. Ueda; K. Katayama; Y. Sugimoto A T3587G germ-line mutation of the MDR1 gene encodes a nonfunctional P-glycoprotein A T3587G germ-line mutation of the MDR1 gene encodes a nonfunctional P-glycoprotein ,5,4,877-884 2006/04 英語 公開
S. Abe-Dohmae; K. Ueda; S. Yokoyama S. Abe-Dohmae; K. Ueda; S. Yokoyama ABCA7, a molecule with unknown function ABCA7, a molecule with unknown function ,580,4,1178-1182 2006 英語 公開
M. Mitsushima; T. Sezaki; R. Akahane; K. Ueda; S. Suetsugu; T. Takenawa; N. Kioka M. Mitsushima; T. Sezaki; R. Akahane; K. Ueda; S. Suetsugu; T. Takenawa; N. Kioka Protein kinase A-dependent increase in WAVE2 expression induced by the focal adhesion protein vinexin Protein kinase A-dependent increase in WAVE2 expression induced by the focal adhesion protein vinexin ,11,3,281-292 2006 英語 公開
M. Mitsushima; H. Takahashi; T. Shishido; K. Ueda; N. Kioka M. Mitsushima; H. Takahashi; T. Shishido; K. Ueda; N. Kioka Abl kinase interacts with and phosphorylates vinexin Abl kinase interacts with and phosphorylates vinexin ,580,17,4288-4295 2006 英語 公開
S. Abe-Dohmae; K.H. Kato; Y. Kumon; W. Hu; H. Ishigami; N. Iwamoto; M. Okazaki; C.-A. Wu; M. Tsujita; K. Ueda; S. Yokoyama S. Abe-Dohmae; K.H. Kato; Y. Kumon; W. Hu; H. Ishigami; N. Iwamoto; M. Okazaki; C.-A. Wu; M. Tsujita; K. Ueda; S. Yokoyama Serum amyloid A generates high density lipoprotein with cellular lipid in an ABCA1- or ABCA7-dependent manner Serum amyloid A generates high density lipoprotein with cellular lipid in an ABCA1- or ABCA7-dependent manner ,47,7,1542-1550 2006 英語 公開
S. Nagao; K. Murao; H. Imachi; W.-M. Cao; X. Yu; J. Li; K. Matsumoto; T. Nishiuchi; R.A.M. Ahmed; N.C.W. Wong; K. Ueda; T. Ishida S. Nagao; K. Murao; H. Imachi; W.-M. Cao; X. Yu; J. Li; K. Matsumoto; T. Nishiuchi; R.A.M. Ahmed; N.C.W. Wong; K. Ueda; T. Ishida Platelet derived growth factor regulates ABCA1 expression in vascular smooth muscle cells Platelet derived growth factor regulates ABCA1 expression in vascular smooth muscle cells ,580,18,4371-4376 2006 英語 公開
A. Kobayashi; Y. Takanezawa; T. Hirata; Y. Shimizu; K. Misasa; N. Kioka; H. Arai; K. Ueda; M. Matsuo A. Kobayashi; Y. Takanezawa; T. Hirata; Y. Shimizu; K. Misasa; N. Kioka; H. Arai; K. Ueda; M. Matsuo Efflux of sphingomyelin, cholesterol, and phosphatidylcholine by ABCG1 Efflux of sphingomyelin, cholesterol, and phosphatidylcholine by ABCG1 ,47,8,1791-1802 2006 英語 公開
M. Mitsushima; K. Ueda; N. Kioka M. Mitsushima; K. Ueda; N. Kioka Vinexin β regulates the phosphorylation of epidermal growth factor receptor on the cell surface Vinexin β regulates the phosphorylation of epidermal growth factor receptor on the cell surface ,11,9,971-982 2006 英語 公開
K. Yazaki; N. Yamanaka; T. Masuno; S. Konagai; N. Shitan; S. Kaneko; K. Ueda; F. Sato K. Yazaki; N. Yamanaka; T. Masuno; S. Konagai; N. Shitan; S. Kaneko; K. Ueda; F. Sato Erratum: Heterologous expression of a mammalian ABC transporter in plant and its application to phytoremediation (Plant Molecular Biology (2006) 61, (3) (491-503) DOI: 10.1007/s11103-006-0024-9) Erratum: Heterologous expression of a mammalian ABC transporter in plant and its application to phytoremediation (Plant Molecular Biology (2006) 61, (3) (491-503) DOI: 10.1007/s11103-006-0024-9) ,61,6,961- 2006 英語 公開
M. Matsuo; Y. Kimura; K. Ueda M. Matsuo; Y. Kimura; K. Ueda K<sub>ATP</sub> channel interaction with adenine nucleotides K<sub>ATP</sub> channel interaction with adenine nucleotides ,38,6,907-916 2005/06 英語 公開
A. Kobayashi; Y. Kimura; M. Matsuo; K. Ueda A. Kobayashi; Y. Kimura; M. Matsuo; K. Ueda ABC proteins as molecular targets for drug discovery ABC proteins as molecular targets for drug discovery ,125,4,185-193 2005 英語 公開
R. Arakawa; N. Tamehiro; T. Nishimaki-Mogami; K. Ueda; S. Yokoyama R. Arakawa; N. Tamehiro; T. Nishimaki-Mogami; K. Ueda; S. Yokoyama Fenofibric acid, an active form of fenofibrate, increases apolipoprotein A-I-mediated high-density lipoprotein biogenesis by enhancing transcription of ATP-binding cassette transporter A1 gene in a liver X receptor-dependent manner Fenofibric acid, an active form of fenofibrate, increases apolipoprotein A-I-mediated high-density lipoprotein biogenesis by enhancing transcription of ATP-binding cassette transporter A1 gene in a liver X receptor-dependent manner ,25,6,1193-1197 2005 英語 公開
N. Ban; M. Sasaki; H. Sakai; K. Ueda; N. Inagaki N. Ban; M. Sasaki; H. Sakai; K. Ueda; N. Inagaki Cloning of ABCA17, a novel rodent sperm-specific ABC (ATP-binding cassette) transporter that regulates intracellular lipid metabolism Cloning of ABCA17, a novel rodent sperm-specific ABC (ATP-binding cassette) transporter that regulates intracellular lipid metabolism ,389,2,577-585 2005 英語 公開
M. Hayashi; S. Abe-Dohmae; M. Okazaki; K. Ueda; S. Yokoyama M. Hayashi; S. Abe-Dohmae; M. Okazaki; K. Ueda; S. Yokoyama Heterogeneity of high density lipoprotein generated by ABCA1 and ABCA7 Heterogeneity of high density lipoprotein generated by ABCA1 and ABCA7 ,46,8,1703-1711 2005 英語 公開
H. Takahashi; M. Mitsushima; N. Okada; T. Ito; S. Aizawa; R. Akahane; T. Umemoto; K. Ueda; N. Kioka H. Takahashi; M. Mitsushima; N. Okada; T. Ito; S. Aizawa; R. Akahane; T. Umemoto; K. Ueda; N. Kioka Role of interaction with vinculin in recruitment of vinexins to focal adhesions Role of interaction with vinculin in recruitment of vinexins to focal adhesions ,336,1,239-246 2005 英語 公開
K. Takahashi; Y. Kimura; K. Nagata; A. Yamamoto; M. Matsuo; K. Ueda K. Takahashi; Y. Kimura; K. Nagata; A. Yamamoto; M. Matsuo; K. Ueda ABC proteins: Key molecules for lipid homeostasis ABC proteins: Key molecules for lipid homeostasis ,38,1,2-12 2005 英語 公開
Y. Toda; R. Aoki; Y. Ikeda; Y. Azuma; N. Kioka; M. Matsuo; M. Sakamoto; S. Mori; M. Fukumoto; K. Ueda Y. Toda; R. Aoki; Y. Ikeda; Y. Azuma; N. Kioka; M. Matsuo; M. Sakamoto; S. Mori; M. Fukumoto; K. Ueda Detection of ABCA7-positive cells in salivary glands from patients with Sjögren\\'s syndrome Detection of ABCA7-positive cells in salivary glands from patients with Sjögren\\'s syndrome ,55,10,639-643 2005 英語 公開
K. Nagata; A. Yamamoto; N. Ban; A.R. Tanaka; M. Matsuo; N. Kioka; N. Inagaki; K. Ueda K. Nagata; A. Yamamoto; N. Ban; A.R. Tanaka; M. Matsuo; N. Kioka; N. Inagaki; K. Ueda Human ABCA3, a product of a responsible gene for abca3 for fatal surfactant deficiency in newborns, exhibits unique ATP hydrolysis activity and generates intracellular multilamellar vesicles Human ABCA3, a product of a responsible gene for abca3 for fatal surfactant deficiency in newborns, exhibits unique ATP hydrolysis activity and generates intracellular multilamellar vesicles ,324,1,262-268 2004/11/05 英語 公開
M. Mitsushima; A. Suwa; T. Amachi; K. Ueda; N. Kioka M. Mitsushima; A. Suwa; T. Amachi; K. Ueda; N. Kioka Extracellular signal-regulated kinase activated by epidermal growth factor and cell adhesion interacts with and phosphorylates vinexin Extracellular signal-regulated kinase activated by epidermal growth factor and cell adhesion interacts with and phosphorylates vinexin ,279,33,34570-34577 2004/08/13 英語 公開
Y. Munehira; T. Ohnishi; S. Kawamoto; A. Furuya; K. Shitara; M. Imamura; T. Yokota; S. Takeda; T. Amachi; M. Matsuo; N. Kioka; K. Ueda Y. Munehira; T. Ohnishi; S. Kawamoto; A. Furuya; K. Shitara; M. Imamura; T. Yokota; S. Takeda; T. Amachi; M. Matsuo; N. Kioka; K. Ueda α1-Syntrophin Modulates Turnover of ABCA1 α1-Syntrophin Modulates Turnover of ABCA1 ,279,15,15091-15095 2004/04/09 英語 公開
Y. Kimura; S. Shibasaki; K. Morisato; N. Ishizuka; H. Minakuchi; K. Nakanishi; M. Matsuo; T. Amachi; M. Ueda; K. Ueda Y. Kimura; S. Shibasaki; K. Morisato; N. Ishizuka; H. Minakuchi; K. Nakanishi; M. Matsuo; T. Amachi; M. Ueda; K. Ueda Microanalysis for MDR1 ATPase by high-performance liquid chromatography with a titanium dioxide column Microanalysis for MDR1 ATPase by high-performance liquid chromatography with a titanium dioxide column ,326,2,262-266 2004/03/15 英語 公開
Y. Kimura; M. Matsuo; K. Takahashi; T. Saeki; N. Kioka; T. Amachi; K. Ueda Y. Kimura; M. Matsuo; K. Takahashi; T. Saeki; N. Kioka; T. Amachi; K. Ueda ATP hydrolysis-dependent multidrug efflux transporter: MDR1/P-glycoprotein ATP hydrolysis-dependent multidrug efflux transporter: MDR1/P-glycoprotein ,5,1,1-10 2004/02 英語 公開
S. Abe-Dohmae; Y. Ikeda; M. Matsuo; M. Hayashi; K.-I. Okuhira; K. Ueda; S. Yokoyama S. Abe-Dohmae; Y. Ikeda; M. Matsuo; M. Hayashi; K.-I. Okuhira; K. Ueda; S. Yokoyama Human ABCA7 Supports Apolipoprotein-mediated Release of Cellular Cholesterol and Phospholipid to Generate High Density Lipoprotein Human ABCA7 Supports Apolipoprotein-mediated Release of Cellular Cholesterol and Phospholipid to Generate High Density Lipoprotein ,279,1,604-611 2004 英語 公開
S. Suzuki; T. Nishimaki-Mogami; N. Tamehiro; K. Inoue; R. Arakawa; S. Abe-Dohmae; A.R. Tanaka; K. Ueda; S. Yokoyama S. Suzuki; T. Nishimaki-Mogami; N. Tamehiro; K. Inoue; R. Arakawa; S. Abe-Dohmae; A.R. Tanaka; K. Ueda; S. Yokoyama Verapamil Increases the Apolipoprotein-Mediated Release of Cellular Cholesterol by Induction of ABCA1 Expression Via Liver X Receptor-Independent Mechanism Verapamil Increases the Apolipoprotein-Mediated Release of Cellular Cholesterol by Induction of ABCA1 Expression Via Liver X Receptor-Independent Mechanism ,24,3,519-525 2004 英語 公開
S. Sasawatari; M. Toki; T. Horie; Y. Nakano; T. Ikeda; K. Ueda; H. Fujise S. Sasawatari; M. Toki; T. Horie; Y. Nakano; T. Ikeda; K. Ueda; H. Fujise Effect of PCB-126 on intracellular accumulation and transepithelial transport of vinblastine in LLC-PK1 and its transformant cells expressing human P-glycoprotein Effect of PCB-126 on intracellular accumulation and transepithelial transport of vinblastine in LLC-PK1 and its transformant cells expressing human P-glycoprotein ,66,9,1079-1085 2004 英語 公開
H. Fujise; S. Sasawatari; T. Annoura; T. Ikeda; K. Ueda H. Fujise; S. Sasawatari; T. Annoura; T. Ikeda; K. Ueda 3,3′,4,4′,5-Pentachlorobiphenyl inhibits drug efflux through P-glycoprotein in KB-3 cells expressing mutant human P-glycoprotein 3,3′,4,4′,5-Pentachlorobiphenyl inhibits drug efflux through P-glycoprotein in KB-3 cells expressing mutant human P-glycoprotein ,2004,3,137-142 2004 英語 公開
Y. Ikeda; S. Abe-Dohmae; Y. Munehira; R. Aoki; S. Kawamoto; A. Furuya; K. Shitara; T. Amachi; N. Kioka; M. Matsuo; S. Yokoyama; K. Ueda Y. Ikeda; S. Abe-Dohmae; Y. Munehira; R. Aoki; S. Kawamoto; A. Furuya; K. Shitara; T. Amachi; N. Kioka; M. Matsuo; S. Yokoyama; K. Ueda Posttranscriptional regulation of human ABCA7 and its function for the apoA-I-dependent lipid release Posttranscriptional regulation of human ABCA7 and its function for the apoA-I-dependent lipid release ,311,2,313-318 2003/11/14 英語 公開
M. Wakabayashi; T. Ito; M. Mitsushima; S. Aizawa; K. Ueda; T. Amachi; N. Kioka M. Wakabayashi; T. Ito; M. Mitsushima; S. Aizawa; K. Ueda; T. Amachi; N. Kioka Interaction of lp-dlg/KIAA0583, a membrane-associated guanylate kinase family protein, with vinexin and β-catenin at sites of cell-cell contact Interaction of lp-dlg/KIAA0583, a membrane-associated guanylate kinase family protein, with vinexin and β-catenin at sites of cell-cell contact ,278,24,21709-21714 2003/06/13 英語 公開
A.R. Tanaka; S. Abe-Dohmae; T. Ohnishi; R. Aoki; G. Morinaga; K.-I. Okuhira; Y. Ikeda; F. Kano; M. Matsuo; N. Kioka; T. Amachi; M. Murata; S. Yokoyama; K. Ueda A.R. Tanaka; S. Abe-Dohmae; T. Ohnishi; R. Aoki; G. Morinaga; K.-I. Okuhira; Y. Ikeda; F. Kano; M. Matsuo; N. Kioka; T. Amachi; M. Murata; S. Yokoyama; K. Ueda Effects of mutations of ABCA1 in the first extracellular domain on subcellular trafficking and ATP binding/hydrolysis Effects of mutations of ABCA1 in the first extracellular domain on subcellular trafficking and ATP binding/hydrolysis ,278,10,8815-8819 2003/03/07 英語 公開
H. Umehara; Y. Nishii; M. Morishima; Y. Kakehi; N. Kioka; T. Amachi; J. Koizumi; M. Hagiwara; K. Ueda H. Umehara; Y. Nishii; M. Morishima; Y. Kakehi; N. Kioka; T. Amachi; J. Koizumi; M. Hagiwara; K. Ueda Effect of cisplatin treatment on speckled distribution of a serine/arginine-rich nuclear protein CROP/Luc7A Effect of cisplatin treatment on speckled distribution of a serine/arginine-rich nuclear protein CROP/Luc7A ,301,2,324-329 2003/02/07 英語 公開
K. Terasaka; N. Shitan; F. Sato; F. Maniwa; K. Ueda; K. Yazaki K. Terasaka; N. Shitan; F. Sato; F. Maniwa; K. Ueda; K. Yazaki Application of vanadate-induced nucleotide trapping to plant cells for detection of ABC proteins Application of vanadate-induced nucleotide trapping to plant cells for detection of ABC proteins ,44,2,198-200 2003/02 英語 公開
N. Shitan; I. Bazin; K. Dan; K. Obata; K. Kigawa; K. Ueda; F. Sato; C. Forestier; K. Yazaki N. Shitan; I. Bazin; K. Dan; K. Obata; K. Kigawa; K. Ueda; F. Sato; C. Forestier; K. Yazaki Involvement of CjMDR1, a plant multidrug-resistance-type ATP-binding cassette protein, in alkaloid transport in Coptis japonica Involvement of CjMDR1, a plant multidrug-resistance-type ATP-binding cassette protein, in alkaloid transport in Coptis japonica ,100,2,751-756 2003/01/21 英語 公開
Y. Sugimoto; S. Tsukahara; Y. Imai; Y. Sugimoto; K. Ueda; T. Tsuruo Y. Sugimoto; S. Tsukahara; Y. Imai; Y. Sugimoto; K. Ueda; T. Tsuruo Reversal of breast cancer resistance protein-mediated drug resistance by estrogen antagonists and agonists Reversal of breast cancer resistance protein-mediated drug resistance by estrogen antagonists and agonists ,2,1,105-112 2003 英語 公開
A.R. Tanaka; K. Tanabe; M. Morita; M. Kurisu; Y. Kasiwayama; M. Matsuo; N. Kioka; T. Amachi; T. Imanaka; K. Ueda A.R. Tanaka; K. Tanabe; M. Morita; M. Kurisu; Y. Kasiwayama; M. Matsuo; N. Kioka; T. Amachi; T. Imanaka; K. Ueda ATP binding/hydrolysis by and phosphorylation of peroxisomal ATP-binding cassette proteins PMP70 (ABCD3) and adrenoleukodystrophy protein (ABCD1) ATP binding/hydrolysis by and phosphorylation of peroxisomal ATP-binding cassette proteins PMP70 (ABCD3) and adrenoleukodystrophy protein (ABCD1) ,277,42,40142-40147 2002/10/18 英語 公開
K. Sakai; N. Shitan; F. Sato; K. Ueda; K. Yazaki K. Sakai; N. Shitan; F. Sato; K. Ueda; K. Yazaki Characterization of berberine transport into Coptis japonica cells and the involvement of ABC protein Characterization of berberine transport into Coptis japonica cells and the involvement of ABC protein ,53,376,1879-1886 2002/09 英語 公開
T. Ohama; K.-I. Hirano; Z. Zhang; R. Aoki; K.-I. Tsujii; Y. Nakagawa-Toyama; K. Tsukamoto; C. Ikegami; A. Matsuyama; M. Ishigami; N. Sakai; H. Hiraoka; K. Ueda; S. Yamashita; Y. Matsuzawa T. Ohama; K.-I. Hirano; Z. Zhang; R. Aoki; K.-I. Tsujii; Y. Nakagawa-Toyama; K. Tsukamoto; C. Ikegami; A. Matsuyama; M. Ishigami; N. Sakai; H. Hiraoka; K. Ueda; S. Yamashita; Y. Matsuzawa Dominant expression of ATP-binding cassette transporter-1 on basolateral surface of Caco-2 cells stimulated by LXR/RXR ligands Dominant expression of ATP-binding cassette transporter-1 on basolateral surface of Caco-2 cells stimulated by LXR/RXR ligands ,296,3,625-630 2002/08/23 英語 公開
M. Matsuo; M. Dabrowski; K. Ueda; F.M. Ashcroft M. Matsuo; M. Dabrowski; K. Ueda; F.M. Ashcroft Mutations in the linker domain of NBD2 of SUR inhibit transduction but not nucleotide binding Mutations in the linker domain of NBD2 of SUR inhibit transduction but not nucleotide binding ,21,16,4250-4258 2002/08/15 英語 公開
A. Suwa; M. Mitsushima; T. Ito; M. Akamatsu; K. Ueda; T. Amachi; N. Kioka A. Suwa; M. Mitsushima; T. Ito; M. Akamatsu; K. Ueda; T. Amachi; N. Kioka Vinexin β regulates the anchorage dependence of ERK2 activation stimulated by epidermal growth factor Vinexin β regulates the anchorage dependence of ERK2 activation stimulated by epidermal growth factor ,277,15,13053-13058 2002/04/12 英語 公開
N. Kioka; K. Ueda; T. Amachi N. Kioka; K. Ueda; T. Amachi Vinexin, CAP/ponsin, ArgBP2: A novel adaptor protein family regulating cytoskeletal organization and signal transduction Vinexin, CAP/ponsin, ArgBP2: A novel adaptor protein family regulating cytoskeletal organization and signal transduction ,27,1,1-7 2002/02 英語 公開
H. Fujise; T. Annoura; S. Sasawatari; T. Ikeda; K. Ueda H. Fujise; T. Annoura; S. Sasawatari; T. Ikeda; K. Ueda Transepithelial transport and cellular accumulation of steroid hormones and polychlorobiphenyl in porcine kidney cells expressed with human P-glycoprotein Transepithelial transport and cellular accumulation of steroid hormones and polychlorobiphenyl in porcine kidney cells expressed with human P-glycoprotein ,46,9-10,1505-1511 2002 英語 公開
K. Hashimoto; T. Uchiumi; T. Konno; T. Ebihara; T. Nakamura; M. Wada; S. Sakisaka; F. Maniwa; T. Amachi; K. Ueda; M. Kuwano K. Hashimoto; T. Uchiumi; T. Konno; T. Ebihara; T. Nakamura; M. Wada; S. Sakisaka; F. Maniwa; T. Amachi; K. Ueda; M. Kuwano Trafficking and functional defects by mutations of the ATP-binding domains in MRP2 in patients with Dubin-Johnson syndrome Trafficking and functional defects by mutations of the ATP-binding domains in MRP2 in patients with Dubin-Johnson syndrome ,36,5 II,1236-1245 2002 英語 公開
植田 和光 植田 和光 Trafficking-defect and functional-defect by mutations of the ATP-binding domains in multidrug resistance protein 2 (MRP2, ABCC2) in patients with Dubin-Johnson syndrome. Trafficking-defect and functional-defect by mutations of the ATP-binding domains in multidrug resistance protein 2 (MRP2, ABCC2) in patients with Dubin-Johnson syndrome. 2002 英語 公開
T. Kawauchi; M. Ikeya; S. Takada; K. Ueda; M. Shirai; Y. Takihara; N. Kioka; T. Amachi T. Kawauchi; M. Ikeya; S. Takada; K. Ueda; M. Shirai; Y. Takihara; N. Kioka; T. Amachi Expression of vinexin α in the dorsal half of the eye and in the cardiac outflow tract and atrioventricular canal Expression of vinexin α in the dorsal half of the eye and in the cardiac outflow tract and atrioventricular canal ,106,1-2,147-150 2001/08 英語 公開
Z.-S. Chen; S. Aoki; M. Komatsu; K. Ueda; T. Sumizawa; T. Furukawa; H. Okumura; X.-Q. Ren; M.G. Belinsky; K. Lee; G.D. Kruh; M. Kobayashi; S.-I. Akiyama Z.-S. Chen; S. Aoki; M. Komatsu; K. Ueda; T. Sumizawa; T. Furukawa; H. Okumura; X.-Q. Ren; M.G. Belinsky; K. Lee; G.D. Kruh; M. Kobayashi; S.-I. Akiyama Reversal of drug resistance mediated by multidrug resistance protein (MRP) 1 by dual effects of agosterol a on MRP1 function Reversal of drug resistance mediated by multidrug resistance protein (MRP) 1 by dual effects of agosterol a on MRP1 function ,93,1,107-113 2001/07/01 英語 公開
A.R. Tanaka; Y. Ikeda; S. Abe-Dohmae; R. Arakawa; K. Sadanami; A. Kidera; S. Nakagawa; T. Nagase; R. Aoki; N. Kioka; T. Amachi; S. Yokoyama; K. Ueda A.R. Tanaka; Y. Ikeda; S. Abe-Dohmae; R. Arakawa; K. Sadanami; A. Kidera; S. Nakagawa; T. Nagase; R. Aoki; N. Kioka; T. Amachi; S. Yokoyama; K. Ueda Human ABCA1 contains a large amino-terminal extracellular domain homologous to an epitope of Sjögren\\'s syndrome Human ABCA1 contains a large amino-terminal extracellular domain homologous to an epitope of Sjögren\\'s syndrome ,283,5,1019-1025 2001/05/25 英語 公開
K. Yazaki; N. Shitan; H. Takamatsu; K. Ueda; F. Sato K. Yazaki; N. Shitan; H. Takamatsu; K. Ueda; F. Sato A novel Coptis japonica multidrug-resistant protein preferentially expressed in the alkaloid-accumulating rhizome A novel Coptis japonica multidrug-resistant protein preferentially expressed in the alkaloid-accumulating rhizome ,52,357,877-879 2001 英語 公開
M. Matsuo; S. Trapp; Y. Tanizawa; N. Kioka; T. Amachi; Y. Oka; F.M. Ashcroft; K. Ueda M. Matsuo; S. Trapp; Y. Tanizawa; N. Kioka; T. Amachi; Y. Oka; F.M. Ashcroft; K. Ueda Functional analysis of a mutant sulfonylurea receptor, SUR1-R1420C, that is responsible for persistent hyperinsulinemic hypoglycemia of infancy Functional analysis of a mutant sulfonylurea receptor, SUR1-R1420C, that is responsible for persistent hyperinsulinemic hypoglycemia of infancy ,275,52,41184-41191 2000/12/29 英語 公開
M. Matsuo; K. Tanabe; N. Kioka; T. Amachi; K. Ueda M. Matsuo; K. Tanabe; N. Kioka; T. Amachi; K. Ueda Different binding properties and affinities for ATP and ADP among sulfonylurea receptor subtypes, SUR1, SUR2A, and SUR2B Different binding properties and affinities for ATP and ADP among sulfonylurea receptor subtypes, SUR1, SUR2A, and SUR2B ,275,37,28757-28763 2000/09/15 英語 公開
L.-X. Zhao; C.-J. Zhou; A. Tanaka; M. Nakata; T. Hirabayashi; T. Amachi; S. Shioda; K. Ueda; N. Inagaki L.-X. Zhao; C.-J. Zhou; A. Tanaka; M. Nakata; T. Hirabayashi; T. Amachi; S. Shioda; K. Ueda; N. Inagaki Cloning, characterization and tissue distribution of the rat ATP-binding cassette (ABC) transporter ABC2/ABCA2 Cloning, characterization and tissue distribution of the rat ATP-binding cassette (ABC) transporter ABC2/ABCA2 ,350,865-872 2000/09/15 英語 公開
K. Nagata; M. Nishitani; M. Matsuo; N. Kioka; T. Amachi; K. Ueda K. Nagata; M. Nishitani; M. Matsuo; N. Kioka; T. Amachi; K. Ueda Nonequivalent nucleotide trapping in the two nucleotide binding folds of the human multidrug resistance protein MRP1 Nonequivalent nucleotide trapping in the two nucleotide binding folds of the human multidrug resistance protein MRP1 ,275,23,17626-17630 2000/06/09 英語 公開
Y. Nishii; M. Morishima; Y. Kakehi; K. Umehara; N. Kioka; Y. Terano; T. Amachi; K. Ueda Y. Nishii; M. Morishima; Y. Kakehi; K. Umehara; N. Kioka; Y. Terano; T. Amachi; K. Ueda CROP/Luc7A, a novel serine/arginine-rich nuclear protein, isolated from cisplatin-resistant cell line CROP/Luc7A, a novel serine/arginine-rich nuclear protein, isolated from cisplatin-resistant cell line ,465,2-3,153-156 2000/01/14 英語 公開
Y. Tanizawa; K. Matsuda; M. Matsuo; Y. Ohta; N. Ochi; M. Adachi; M. Koga; S. Mizuno; M. Kajita; Y. Tanaka; K. Tachibana; H. Inoue; S. Furukawa; T. Amachi; K. Ueda; Y. Oka Y. Tanizawa; K. Matsuda; M. Matsuo; Y. Ohta; N. Ochi; M. Adachi; M. Koga; S. Mizuno; M. Kajita; Y. Tanaka; K. Tachibana; H. Inoue; S. Furukawa; T. Amachi; K. Ueda; Y. Oka Genetic analysis of Japanese patients with persistent hyperinsulinemic hypoglycemia of infancy: Nucleotide-binding fold-2 mutation impairs cooperative binding of adenine nucleotides to sulfonylurea receptor 1 Genetic analysis of Japanese patients with persistent hyperinsulinemic hypoglycemia of infancy: Nucleotide-binding fold-2 mutation impairs cooperative binding of adenine nucleotides to sulfonylurea receptor 1 ,49,1,114-120 2000/01 英語 公開
K. Tanabe; S.J. Tucker; F.M. Ashcroft; P. Proks; N. Kioka; T. Amachi; K. Ueda K. Tanabe; S.J. Tucker; F.M. Ashcroft; P. Proks; N. Kioka; T. Amachi; K. Ueda Direct photoaffinity labeling of Kir6.2 by [γ-<sup>32</sup>P]ATP-[γ]4-azidoanilide Direct photoaffinity labeling of Kir6.2 by [γ-<sup>32</sup>P]ATP-[γ]4-azidoanilide ,272,2,316-319 2000 英語 公開
M. Matsuo; N. Kioka; T. Amachi; K. Ueda M. Matsuo; N. Kioka; T. Amachi; K. Ueda ATP binding properties of the nucleotide-binding folds of SUR1 ATP binding properties of the nucleotide-binding folds of SUR1 ,274,52,37479-37482 1999/12/24 英語 公開
M. Akamatsu; S.-I. Aota; A. Suwa; K. Ueda; T. Amachi; K.M. Yamada; S.K. Akiyama; N. Kioka M. Akamatsu; S.-I. Aota; A. Suwa; K. Ueda; T. Amachi; K.M. Yamada; S.K. Akiyama; N. Kioka Vinexin forms a signaling complex with Sos and modulates epidermal growth factor-induced c-Jun N-terminal kinase/stress-activated protein kinase activities Vinexin forms a signaling complex with Sos and modulates epidermal growth factor-induced c-Jun N-terminal kinase/stress-activated protein kinase activities ,274,50,35933-35937 1999/12/10 英語 公開
K. Ueda; M. Matsuo; K. Tanabe; K. Morita; N. Kioka; T. Amachi K. Ueda; M. Matsuo; K. Tanabe; K. Morita; N. Kioka; T. Amachi Comparative aspects of the function and mechanism of SUR1 and MDR1 proteins Comparative aspects of the function and mechanism of SUR1 and MDR1 proteins ,1461,2,305-313 1999/12/06 英語 公開
T. Ashizawa; K. Kawashima; Y. Kanda; K. Goml; M. Okabe; K. Ueda; T. Tamaoki T. Ashizawa; K. Kawashima; Y. Kanda; K. Goml; M. Okabe; K. Ueda; T. Tamaoki Antitumor activity of KF22678, a novel thioester derivative of leinamycin Antitumor activity of KF22678, a novel thioester derivative of leinamycin ,10,9,829-836 1999/10 英語 公開
M. Matsuo; S.J. Tucker; F.M. Ashcroft; T. Amachi; K. Ueda M. Matsuo; S.J. Tucker; F.M. Ashcroft; T. Amachi; K. Ueda NEM modification prevents high-affinity ATP binding to the first nucleotide binding fold of the sulphonylurea receptor, SUR1 NEM modification prevents high-affinity ATP binding to the first nucleotide binding fold of the sulphonylurea receptor, SUR1 ,458,3,292-294 1999/09/24 英語 公開
S. Tsuruoka; K.-I. Sugimoto; K. Ueda; M. Suzuki; M. Imai; A. Fujimura S. Tsuruoka; K.-I. Sugimoto; K. Ueda; M. Suzuki; M. Imai; A. Fujimura Removal of digoxin and doxorubicin by multidrug resistance protein- overexpressed cell culture in hollow fiber Removal of digoxin and doxorubicin by multidrug resistance protein- overexpressed cell culture in hollow fiber ,56,1,154-163 1999/07 英語 公開
Z.-S. Chen; T. Furukawa; T. Sumizawa; K. Ono; K. Ueda; K. Seto; S.-I. Akiyama Z.-S. Chen; T. Furukawa; T. Sumizawa; K. Ono; K. Ueda; K. Seto; S.-I. Akiyama ATP-dependent efflux of CPT-11 and SN-38 by the multidrug resistance protein (MRP) and its inhibition by PAK-104P ATP-dependent efflux of CPT-11 and SN-38 by the multidrug resistance protein (MRP) and its inhibition by PAK-104P ,55,5,921-928 1999/05 英語 公開
K. Ueda; A. Yoshida; T. Amachi K. Ueda; A. Yoshida; T. Amachi Recent progress in P-glycoprotein research Recent progress in P-glycoprotein research ,14,2,115-121 1999/04 英語 公開
K. Ueda; J. Komine; M. Matsuo; S. Seino; T. Amachi K. Ueda; J. Komine; M. Matsuo; S. Seino; T. Amachi Cooperative binding of ATP and MgADP in the sulfonylurea receptor is modulated by glibenclamide Cooperative binding of ATP and MgADP in the sulfonylurea receptor is modulated by glibenclamide ,96,4,1268-1272 1999/02/16 英語 公開
K. Tanabe; S.J. Tucker; M. Matsuo; P. Proks; F.M. Ashcroft; S. Seino; T. Amachi; K. Ueda K. Tanabe; S.J. Tucker; M. Matsuo; P. Proks; F.M. Ashcroft; S. Seino; T. Amachi; K. Ueda Direct photoaffinity labeling of the Kir6.2 Subunit of the ATP-sensitive K<sup>+</sup> channel by 8-azido-ATP Direct photoaffinity labeling of the Kir6.2 Subunit of the ATP-sensitive K<sup>+</sup> channel by 8-azido-ATP ,274,7,3931-3933 1999/02/12 英語 公開
N. Kusunoki; K. Takara; Y. Tanigawara; A. Yamauchi; K. Ueda; F. Komada; Y. Ku; Y. Kuroda; Y. Saitoh; K. Okumura N. Kusunoki; K. Takara; Y. Tanigawara; A. Yamauchi; K. Ueda; F. Komada; Y. Ku; Y. Kuroda; Y. Saitoh; K. Okumura Inhibitory effects of a cyclosporin derivative, SDZ PSC 833, on transport of doxorubicin and vinblastine via human P-glycoprotein Inhibitory effects of a cyclosporin derivative, SDZ PSC 833, on transport of doxorubicin and vinblastine via human P-glycoprotein ,89,11,1220-1228 1998/11 英語 公開
Y. Takada; K. Yamada; Y. Taguchi; K. Kino; M. Matsuo; S.J. Tucker; T. Komano; T. Amachi; K. Ueda Y. Takada; K. Yamada; Y. Taguchi; K. Kino; M. Matsuo; S.J. Tucker; T. Komano; T. Amachi; K. Ueda Non-equivalent cooperation between the two nucleotide-binding folds of P-glycoprotein Non-equivalent cooperation between the two nucleotide-binding folds of P-glycoprotein ,1373,1,131-136 1998/08/14 英語 公開
K. Ueda; N. Inagaki; S. Seino K. Ueda; N. Inagaki; S. Seino MgADP antagonism to Mg<sup>2+</sup>-independent ATP binding of the sulfonylurea receptor SUR1 MgADP antagonism to Mg<sup>2+</sup>-independent ATP binding of the sulfonylurea receptor SUR1 ,272,37,22983-22986 1997/09/12 英語 公開
Y. Taguchi; M. Morishima; T. Komano; K. Ueda Y. Taguchi; M. Morishima; T. Komano; K. Ueda Amino acid substitutions in the first transmembrane domain (TM1) of P-glycoprotein that alter substrate specificity Amino acid substitutions in the first transmembrane domain (TM1) of P-glycoprotein that alter substrate specificity ,413,1,142-146 1997/08/11 英語 公開
Y. Taguchi; K. Kino; M. Morishima; T. Komano; S.E. Kane; K. Ueda Y. Taguchi; K. Kino; M. Morishima; T. Komano; S.E. Kane; K. Ueda Alteration of substrate specificity by mutations at the His<sup>61</sup> position in predicted transmembrane domain 1 of human MDR1/P-Glycoprotein Alteration of substrate specificity by mutations at the His<sup>61</sup> position in predicted transmembrane domain 1 of human MDR1/P-Glycoprotein ,36,29,8883-8889 1997/07/22 英語 公開
A. Miwa; K. Ueda; Y. Okada A. Miwa; K. Ueda; Y. Okada Protein kinase C-independent correlation between P-glycoprotein expression and volume sensitivity of Cl<sup>-</sup> channel Protein kinase C-independent correlation between P-glycoprotein expression and volume sensitivity of Cl<sup>-</sup> channel ,157,1,63-69 1997/05/01 英語 公開
K. Tanaka; M. Hirai; Y. Tanigawara; K. Ueda; M. Takano; R. Hori; K.-I. Inui K. Tanaka; M. Hirai; Y. Tanigawara; K. Ueda; M. Takano; R. Hori; K.-I. Inui Relationship between expression level of P-glycoprotein and daunorubicin transport in LLC-PK<sub>1</sub> cells transfected with human MDR1 gene Relationship between expression level of P-glycoprotein and daunorubicin transport in LLC-PK<sub>1</sub> cells transfected with human MDR1 gene ,53,5,741-746 1997/03/07 英語 公開
Y. Taguchi; A. Yoshida; Y. Takada; T. Komano; K. Ueda Y. Taguchi; A. Yoshida; Y. Takada; T. Komano; K. Ueda Anti-cancer drugs and glutathione stimulate vanadate-induced trapping of nucleotide in multidrug resistance-associated protein (MRP) Anti-cancer drugs and glutathione stimulate vanadate-induced trapping of nucleotide in multidrug resistance-associated protein (MRP) ,401,1,11-14 1997/01/13 英語 公開
Y. Okada; S. Oiki; M. Tominaga; M. Kubo; A. Miwa; T. Tominaga; T. Tsumura; K. Ueda Y. Okada; S. Oiki; M. Tominaga; M. Kubo; A. Miwa; T. Tominaga; T. Tsumura; K. Ueda Volume-sensitive Cl<sup>-</sup> channel in human epithelial cells: Regulation by ATP and relation to P-glycoprotein Volume-sensitive Cl<sup>-</sup> channel in human epithelial cells: Regulation by ATP and relation to P-glycoprotein ,47,SUPPL. 1,S19-S20 1997 英語 公開
K. Ueda; Y. Taguchi; M. Morishima K. Ueda; Y. Taguchi; M. Morishima How does P-glycoprotein recognize its substrates? How does P-glycoprotein recognize its substrates? ,8,3,151-159 1997 英語 公開
K. Kino; Y. Taguchi; K. Yamada; T. Komano; K. Ueda K. Kino; Y. Taguchi; K. Yamada; T. Komano; K. Ueda Aureobasidin A, an antifungal cyclic depsipeptide antibiotic, is a substrate for both human MDR1 and MDR2/P-glycoproteins Aureobasidin A, an antifungal cyclic depsipeptide antibiotic, is a substrate for both human MDR1 and MDR2/P-glycoproteins ,399,1-2,29-32 1996/12/09 英語 公開
K. Tanaka; M. Hirai; Y. Tanigawara; M. Yasuhara; R. Hori; K. Ueda; K.-I. Inui K. Tanaka; M. Hirai; Y. Tanigawara; M. Yasuhara; R. Hori; K. Ueda; K.-I. Inui Effect of cyclosporin analogues and FK506 on transcellular transport of daunorubicin and vinblastine via P-glycoprotein Effect of cyclosporin analogues and FK506 on transcellular transport of daunorubicin and vinblastine via P-glycoprotein ,13,7,1073-1077 1996/07 英語 公開
M. Hirai; K. Tanaka; T. Shimizu; Y. Tanigawara; M. Yasuhara; R. Hori; Y. Kakehi; O. Yoshida; K. Ueda; T. Komano; K.-I. Inui M. Hirai; K. Tanaka; T. Shimizu; Y. Tanigawara; M. Yasuhara; R. Hori; Y. Kakehi; O. Yoshida; K. Ueda; T. Komano; K.-I. Inui Cepharanthin, a multidrug resistant modifier, is a substrate for P- glycoprotein Cepharanthin, a multidrug resistant modifier, is a substrate for P- glycoprotein ,275,1,73-78 1995/10 英語 公開
K.T. Nguyen; B. Liu; K. Ueda; M.M. Gottesman; I. Pastan; K.-V. Chin K.T. Nguyen; B. Liu; K. Ueda; M.M. Gottesman; I. Pastan; K.-V. Chin Transactivation of the human multidrug resistance (MDR1) gene promoter by p53 mutants Transactivation of the human multidrug resistance (MDR1) gene promoter by p53 mutants ,6,2,71-77 1994 英語 公開
K. Ueda; T. Saeki; M. Hirai; Y. Tanigawara; K. Tanaka; M. Okamura; M. Yasuhara; R. Hori; K. Inui; T. Komano K. Ueda; T. Saeki; M. Hirai; Y. Tanigawara; K. Tanaka; M. Okamura; M. Yasuhara; R. Hori; K. Inui; T. Komano Human P-glycoprotein as a multi-drug transporter analyzed by using transepithelial transport system. Human P-glycoprotein as a multi-drug transporter analyzed by using transepithelial transport system. ,44,S67-S71 1994 英語 公開
K. Ueda; A.M. Shimabuku; H. Konishi; Y. Fujii; S. Takebe; K. Nishi; M. Yoshida; T. Beppu; T. Komano K. Ueda; A.M. Shimabuku; H. Konishi; Y. Fujii; S. Takebe; K. Nishi; M. Yoshida; T. Beppu; T. Komano Functional expression of human P-glycoprotein in Schizosaccharomyces pombe Functional expression of human P-glycoprotein in Schizosaccharomyces pombe ,330,3,279-282 1993/09/20 英語 公開
N. Okamura; M. Hirai; Y. Tanigawara; K. Tanaka; M. Yasuhara; K. Ueda; T. Komano; R. Hori N. Okamura; M. Hirai; Y. Tanigawara; K. Tanaka; M. Yasuhara; K. Ueda; T. Komano; R. Hori Digoxin-cyclosporin A interaction: Modulation of the multidrug transporter P-glycoprotein in the kidney Digoxin-cyclosporin A interaction: Modulation of the multidrug transporter P-glycoprotein in the kidney ,266,3,1614-1619 1993/09 英語 公開
T. Saeki; K. Ueda; Y. Tanigawara; R. Hori; T. Komano T. Saeki; K. Ueda; Y. Tanigawara; R. Hori; T. Komano P-glycoprotein-mediated transcellular transport of MDR-reversing agents P-glycoprotein-mediated transcellular transport of MDR-reversing agents ,324,1,99-102 1993/06/07 英語 公開
T. Saeki; K. Ueda; Y. Tanigawara; R. Hori; T. Komano T. Saeki; K. Ueda; Y. Tanigawara; R. Hori; T. Komano Human P-glycoprotein transports cyclosporin A and FK506 Human P-glycoprotein transports cyclosporin A and FK506 ,268,9,6077-6080 1993/03/25 英語 公開
K. Ueda; N. Okamura; M. Hirai; Y. Tanigawara; T. Saeki; N. Kioka; T. Komano; R. Hori K. Ueda; N. Okamura; M. Hirai; Y. Tanigawara; T. Saeki; N. Kioka; T. Komano; R. Hori Human P-glycoprotein transports cortisol, aldosterone, and dexamethasone, but not progesterone Human P-glycoprotein transports cortisol, aldosterone, and dexamethasone, but not progesterone ,267,34,24248-24252 1992/12/05 英語 公開
Y. Tanigawara; N. Okamura; M. Hirai; M. Yasuhara; K. Ueda; N. Kioka; T. Komano; R. Hori Y. Tanigawara; N. Okamura; M. Hirai; M. Yasuhara; K. Ueda; N. Kioka; T. Komano; R. Hori Transport of digoxin by human P-glycoprotein expressed in a porcine kidney epithelial cell line (LLC-PK<sub>1</sub>) Transport of digoxin by human P-glycoprotein expressed in a porcine kidney epithelial cell line (LLC-PK<sub>1</sub>) ,263,2,840-845 1992/11 英語 公開
I. Sugawara; A. Hirata; K. Ueda; S. Itoyama I. Sugawara; A. Hirata; K. Ueda; S. Itoyama Preparation and characterization of a murine monoclonal antibody (MDR3M) reactive with mdr3 gene product Preparation and characterization of a murine monoclonal antibody (MDR3M) reactive with mdr3 gene product ,83,8,795-797 1992/08 英語 公開
T. Saeki; A.M. Shimabuku; K. Ueda; T. Komano T. Saeki; A.M. Shimabuku; K. Ueda; T. Komano Specific drug binding by purified lipid-reconstituted P-glycoprotein: Dependence on the lipid composition Specific drug binding by purified lipid-reconstituted P-glycoprotein: Dependence on the lipid composition ,1107,1,105-110 1992/06/11 英語 公開
N. Kioka; N. Hosokawa; T. Komano; K. Hirayoshi; K. Nagate; K. Ueda N. Kioka; N. Hosokawa; T. Komano; K. Hirayoshi; K. Nagate; K. Ueda Quercetin, a bioflavonoid, inhibits the increase of human multidrug resistance gene (MDR1) expression caused by arsenite Quercetin, a bioflavonoid, inhibits the increase of human multidrug resistance gene (MDR1) expression caused by arsenite ,301,3,307-309 1992/04/27 英語 公開
N. Kioka; Y. Yamano; T. Komano; K. Ueda N. Kioka; Y. Yamano; T. Komano; K. Ueda Heat-shock responsive elements in the induction of the multidrug resistance gene (MDR1) Heat-shock responsive elements in the induction of the multidrug resistance gene (MDR1) ,301,1,37-40 1992/04/13 英語 公開
A.M. Shimabuku; T. Nishimoto; K. Uedat; T. Komano A.M. Shimabuku; T. Nishimoto; K. Uedat; T. Komano P-glycoprotein: ATP hydrolysis by the N-terminal nucleotide-binding domain P-glycoprotein: ATP hydrolysis by the N-terminal nucleotide-binding domain ,267,7,4308-4311 1992/03/05 英語 公開
K. Ueda; H. Hiasa; S. Takebe; H. Sakai; T. Komano K. Ueda; H. Hiasa; S. Takebe; H. Sakai; T. Komano Alternative secondary structures in the phage G4 origin of the complementary DNA strand synthesis: effects of NaCl concentration on the bleomycin-DNA interaction. Alternative secondary structures in the phage G4 origin of the complementary DNA strand synthesis: effects of NaCl concentration on the bleomycin-DNA interaction. ,56,3,394-398 1992/03 英語 公開
I. Sugawara; M. Watanabe; A. Masunaga; S. Itoyama; K. Ueda I. Sugawara; M. Watanabe; A. Masunaga; S. Itoyama; K. Ueda Primer-dependent amplification of mdr1 mRNA by polymerase chain reaction Primer-dependent amplification of mdr1 mRNA by polymerase chain reaction ,83,2,131-133 1992/02 英語 公開
K.-V. Chin; K. Ueda; I. Pastan; M.M. Gottesman K.-V. Chin; K. Ueda; I. Pastan; M.M. Gottesman Modulation of activity of the promoter of the human MDR1 gene by Ras and p53 Modulation of activity of the promoter of the human MDR1 gene by Ras and p53 ,255,5043,459-462 1992/01/24 英語 公開
T. Saeki; A.M. Shimabuku; Y. Azuma; Y. Shibano; T. Komano; K. Ueda T. Saeki; A.M. Shimabuku; Y. Azuma; Y. Shibano; T. Komano; K. Ueda Expression of human P-glycoprotein in yeast cells--effects of membrane component sterols on the activity of P-glycoprotein. Expression of human P-glycoprotein in yeast cells--effects of membrane component sterols on the activity of P-glycoprotein. ,55,7,1859-1865 1991/07 英語 公開
A.M. Shimabuku; T. Saeki; K. Ueda; T. Komano A.M. Shimabuku; T. Saeki; K. Ueda; T. Komano Production of a site specifically cleavable P-glycoprotein-beta-galactosidase fusion protein. Production of a site specifically cleavable P-glycoprotein-beta-galactosidase fusion protein. ,55,4,1075-1080 1991/04 英語 公開
H. Kuroda; T. Sugimoto; K. Ueda; S. Tsuchida; Y. Horii; J. Inazawa; K. Sato; T. Sawada H. Kuroda; T. Sugimoto; K. Ueda; S. Tsuchida; Y. Horii; J. Inazawa; K. Sato; T. Sawada Different drug sensitivity in two neuroblastoma cell lines established from the same patient before and after chemotherapy Different drug sensitivity in two neuroblastoma cell lines established from the same patient before and after chemotherapy ,47,5,732-737 1991/03/12 英語 公開
I. Sugawara; T. Koji; K. Ueda; I. Pastan; M.M. Gottesman; P.K. Nakane; S. Mori I. Sugawara; T. Koji; K. Ueda; I. Pastan; M.M. Gottesman; P.K. Nakane; S. Mori In situ localization of the human multidrug-resistance gene mRNA using thymine-thymine dimerized single-stranded cDNA In situ localization of the human multidrug-resistance gene mRNA using thymine-thymine dimerized single-stranded cDNA ,81,9,949-955 1990/09 英語 公開
J.R. McLachlin; M.A. Eglitis; K. Ueda; P.W. Kantoff; I.H. Pastan; W.F. Anderson; M.M. Gottesman J.R. McLachlin; M.A. Eglitis; K. Ueda; P.W. Kantoff; I.H. Pastan; W.F. Anderson; M.M. Gottesman Expression of a human complementary DNA for the multidrug resistance gene in murine hematopoietic precursor cells with the use of retroviral gene transfer Expression of a human complementary DNA for the multidrug resistance gene in murine hematopoietic precursor cells with the use of retroviral gene transfer ,82,15,1260-1263 1990/08/01 英語 公開
S. Tanaka; S.J. Currier; E.P. Bruggemann; K. Ueda; U.A. Germann; I. Pastan; M.M. Gottesman S. Tanaka; S.J. Currier; E.P. Bruggemann; K. Ueda; U.A. Germann; I. Pastan; M.M. Gottesman Use of recombinant P-glycoprotein fragments to produce antibodies to the multidrug transporter Use of recombinant P-glycoprotein fragments to produce antibodies to the multidrug transporter ,166,1,180-186 1990/01/15 英語 公開
L.J. Goldstein; A.T. Fojo; K. Ueda; W. Crist; A. Green; G. Brodeur; I. Pastan; M.M. Gottesman L.J. Goldstein; A.T. Fojo; K. Ueda; W. Crist; A. Green; G. Brodeur; I. Pastan; M.M. Gottesman Expression of the multidrug resistance, MDR1, gene in neuroblastomas Expression of the multidrug resistance, MDR1, gene in neuroblastomas ,8,1,128-136 1990/01 英語 公開
S. Kobayashi; K. Ueda; T. Komano S. Kobayashi; K. Ueda; T. Komano The effects of metal ions on the DNA damage induced by hydrogen peroxide. The effects of metal ions on the DNA damage induced by hydrogen peroxide. ,54,1,69-76 1990/01 英語 公開
C.-J. Chen; D. Clark; K. Ueda; I. Pastan; M.M. Gottesman; I.B. Roninson C.-J. Chen; D. Clark; K. Ueda; I. Pastan; M.M. Gottesman; I.B. Roninson Genomic organization of the human multidrug resistance (MDR1) gene and origin of P-glycoproteins Genomic organization of the human multidrug resistance (MDR1) gene and origin of P-glycoproteins ,265,1,506-514 1990 英語 公開
K. Ueda; Y. Yamano; N. Kioka; Y. Kakehi; O. Yoshida; M.M. Gottesman; I. Pastan; T. Komano K. Ueda; Y. Yamano; N. Kioka; Y. Kakehi; O. Yoshida; M.M. Gottesman; I. Pastan; T. Komano Detection of multidrug resistance (MDR1) gene RNA expression in human tumors by a sensitive ribonuclease protection assay Detection of multidrug resistance (MDR1) gene RNA expression in human tumors by a sensitive ribonuclease protection assay ,80,11,1127-1132 1989/11 英語 公開
S.J. Currier; K. Ueda; M.C. Willingham; I. Pastan; M.M. Gottesman S.J. Currier; K. Ueda; M.C. Willingham; I. Pastan; M.M. Gottesman Deletion and insertion mutants of the multidrug transporter Deletion and insertion mutants of the multidrug transporter ,264,24,14376-14381 1989/08/25 英語 公開
N. Kioka; J. Tsubota; Y. Kakehi; T. Komano; M.M. Gottesman; I. Pastan; K. Ueda N. Kioka; J. Tsubota; Y. Kakehi; T. Komano; M.M. Gottesman; I. Pastan; K. Ueda P-Glycoprotein gene (MDR1) cDNA from human adrenal: Normal P-glycoprotein carries Gly<sup>185</sup> with an altered pattern of multidrug resistance P-Glycoprotein gene (MDR1) cDNA from human adrenal: Normal P-glycoprotein carries Gly<sup>185</sup> with an altered pattern of multidrug resistance ,162,1,224-231 1989/07/14 英語 公開
S.E. Kane; B.R. Troen; S. Gal; K. Ueda; I. Pastan; M.M. Gottesman S.E. Kane; B.R. Troen; S. Gal; K. Ueda; I. Pastan; M.M. Gottesman Use of cloned multidrug resistance gene for coamplification and overproduction of major excreted protein,a transformation-regulated secreted acid protease Use of cloned multidrug resistance gene for coamplification and overproduction of major excreted protein,a transformation-regulated secreted acid protease ,8,8,3316-3321 1988/08 英語 公開
S. Kobayashi; K. Ueda; J. Morita; H. Sakai; T. Komano S. Kobayashi; K. Ueda; J. Morita; H. Sakai; T. Komano DNA damage induced by ascorbate in the presence of Cu<sup>2+</sup> DNA damage induced by ascorbate in the presence of Cu<sup>2+</sup> ,949,1,143-147 1988/01/25 英語 公開
I. Pastan; M.M. Gottesman; K. Ueda; E. Lovelace; A.V. Rutherford; M.C. Willingham I. Pastan; M.M. Gottesman; K. Ueda; E. Lovelace; A.V. Rutherford; M.C. Willingham A retrovirus carrying an MDR1 cDNA confers multidrug resistance and polarized expression of P-glycoprotein in MDCK cells A retrovirus carrying an MDR1 cDNA confers multidrug resistance and polarized expression of P-glycoprotein in MDCK cells ,85,12,4486-4490 1988 英語 公開
K. Ueda; T. Komano K. Ueda; T. Komano The multidrug-resistance gene MDR1 The multidrug-resistance gene MDR1 ,15,10,2858-2862 1988 英語 公開
K. Ueda; I. Pastan; M.M. Gottesman K. Ueda; I. Pastan; M.M. Gottesman Isolation and sequence of the promotor region of the human multidrug-resistance (P-glycoprotein) gene Isolation and sequence of the promotor region of the human multidrug-resistance (P-glycoprotein) gene ,262,36,17432-17436 1987/12/25 英語 公開
K. Ueda; C. Cardarelli; M.M. Gottesman; T. Pastan K. Ueda; C. Cardarelli; M.M. Gottesman; T. Pastan Expression of a full-length cDNA for the human \\'MDR1\\' gene confers resistance to colchicine, doxorubicin, and vinblastine Expression of a full-length cDNA for the human \\'MDR1\\' gene confers resistance to colchicine, doxorubicin, and vinblastine ,84,9,3004-3008 1987/05 英語 公開
A.T. Fojo; K. Ueda; D.J. Slamon; D.G. Poplack; M.M. Gottesman; I. Pastan A.T. Fojo; K. Ueda; D.J. Slamon; D.G. Poplack; M.M. Gottesman; I. Pastan Expression of a multidrug-resistance gene in human tumors and tissues Expression of a multidrug-resistance gene in human tumors and tissues ,84,1,265-269 1987/01 英語 公開
植田 和光 植田 和光 The human multidrug resistance(mdrl)gene. The human multidrug resistance(mdrl)gene. 1987 英語 公開
K. Ueda; M.M. Cornwell; M.M. Gottesman; I. Pastan; I.B. Roninson; V. Ling; J.R. Riordan K. Ueda; M.M. Cornwell; M.M. Gottesman; I. Pastan; I.B. Roninson; V. Ling; J.R. Riordan The mdrl gene, responsible for multidrug-resistance, codes for P-glycoprotein The mdrl gene, responsible for multidrug-resistance, codes for P-glycoprotein ,141,3,956-962 1986/12/30 英語 公開
J. Morita; K. Ueda; S. Kobayashi; T. Komano J. Morita; K. Ueda; S. Kobayashi; T. Komano Sequence-specific modification of DNA by 6-hydroxybenzo[a]pyrene Sequence-specific modification of DNA by 6-hydroxybenzo[a]pyrene ,868,1,87-90 1986/10/16 英語 公開
植田 和光 植田 和光 Internal dupilication and homology with bacterial transport proteins in the mdrl (P-glycoprotein) gene from multidrug-resistance human cells Internal dupilication and homology with bacterial transport proteins in the mdrl (P-glycoprotein) gene from multidrug-resistance human cells 1986 英語 公開
S. Nanjou; S. Fujii; J. Morita; K. Ueda; T. Komano S. Nanjou; S. Fujii; J. Morita; K. Ueda; T. Komano Sequence-specific alkali-labile lesions in DNA caused by d-isoglucosamine Sequence-specific alkali-labile lesions in DNA caused by d-isoglucosamine ,866,1,44-52 1986 英語 公開
C.-j. Chen; J.E. Chin; K. Ueda; D.P. Clark; I. Pastan; M.M. Gottesman; I.B. Roninson C.-j. Chen; J.E. Chin; K. Ueda; D.P. Clark; I. Pastan; M.M. Gottesman; I.B. Roninson Internal duplication and homology with bacterial transport proteins in the mdr1 (P-glycoprotein) gene from multidrug-resistant human cells Internal duplication and homology with bacterial transport proteins in the mdr1 (P-glycoprotein) gene from multidrug-resistant human cells ,47,3,381-389 1986 英語 公開
J. Morita; K. Ueda; S. Nanjo; T. Komanol J. Morita; K. Ueda; S. Nanjo; T. Komanol Sequence specific damage of DNA induced by reducing sugars Sequence specific damage of DNA induced by reducing sugars ,13,2,449-458 1985 英語 公開
NANJOU, S; FUJII, S; TANAKA, K; UEDA, K; KOMANO, T NANJOU, S; FUJII, S; TANAKA, K; UEDA, K; KOMANO, T INDUCTION OF SINGLE-STRAND SCISSION IN PHI-X174 RFI DNA BY D-ISOGLUCOSAMINE INDUCTION OF SINGLE-STRAND SCISSION IN PHI-X174 RFI DNA BY D-ISOGLUCOSAMINE ,49,2,459-466 1985 英語 公開
K. Ueda; S. Kobayashi; J. Morita; T. Komano K. Ueda; S. Kobayashi; J. Morita; T. Komano Site-specific DNA damage caused by lipid peroxidation products Site-specific DNA damage caused by lipid peroxidation products ,824,4,341-348 1985 英語 公開
K. Ueda; S. Kobayashi; H. Sakai; T. Komano K. Ueda; S. Kobayashi; H. Sakai; T. Komano Cleavage of stem-and-loop structure DNA by bleomycin. Reaction on the bacteriophage G4 origin of complementary strand synthesis Cleavage of stem-and-loop structure DNA by bleomycin. Reaction on the bacteriophage G4 origin of complementary strand synthesis ,260,9,5804-5807 1985 英語 公開
I. Saito; H. Sugiyama; T. Matsuura; K. Ueda; T. Komano I. Saito; H. Sugiyama; T. Matsuura; K. Ueda; T. Komano A new procedure for determining thymine residues in DNA sequencing. Photoinduced cleavage of DNA fragments in the presence of spermine A new procedure for determining thymine residues in DNA sequencing. Photoinduced cleavage of DNA fragments in the presence of spermine ,12,6,2879-2885 1984 英語 公開
K. Ueda; J. Morita; T. Komano K. Ueda; J. Morita; T. Komano Sequence specificity of heat-labile sites in DNA induced by mitomycin C Sequence specificity of heat-labile sites in DNA induced by mitomycin C ,23,8,1634-1640 1984 英語 公開
K. Ueda; T. Komano K. Ueda; T. Komano Sequence-specific DNA damage induced by reduced mitomycin C and 7-N-(p-hydroxyphenyl)mitomycin C Sequence-specific DNA damage induced by reduced mitomycin C and 7-N-(p-hydroxyphenyl)mitomycin C ,12,17,6673-6683 1984 英語 公開
NANJOU, S; FUJII, S; TANAKA, K; UEDA, K; KOMANO, T NANJOU, S; FUJII, S; TANAKA, K; UEDA, K; KOMANO, T INDUCTION OF STRAND BREAKAGE IN PHI-X174 RFI DNA BY AMINOSUGAR DERIVATIVES INDUCTION OF STRAND BREAKAGE IN PHI-X174 RFI DNA BY AMINOSUGAR DERIVATIVES ,48,11,2865-2867 1984 英語 公開
MORITA, J; UEDA, K; NAKAI, K; BABA, Y; KOMANO, T MORITA, J; UEDA, K; NAKAI, K; BABA, Y; KOMANO, T DNA STRAND BREAKAGE INVITRO BY AUTOXIDIZED UNSATURATED FATTY-ACIDS DNA STRAND BREAKAGE INVITRO BY AUTOXIDIZED UNSATURATED FATTY-ACIDS ,47,12,2977-2979 1983 英語 公開
K. Ueda; J. Morita; T. Komano K. Ueda; J. Morita; T. Komano Actions of mitomycin C reduced with sodium borohydride on bacteriophage ∅X174 and its single- and double-stranded DNAs Actions of mitomycin C reduced with sodium borohydride on bacteriophage ∅X174 and its single- and double-stranded DNAs ,46,6,1695-1697 1982 英語 公開
K. Ueda; J. Morita; T. Komano K. Ueda; J. Morita; T. Komano Phage inactivation and DNA strand scission activities of 7-N-(p-hydroxyphenyl)mitomycin C Phage inactivation and DNA strand scission activities of 7-N-(p-hydroxyphenyl)mitomycin C ,35,10,1380-1386 1982 英語 公開
K. Ueda; J. Morita; T. Komano K. Ueda; J. Morita; T. Komano Induction of single strand scission in bacteriophage φX174 replicative form I DNA by mitomycin C Induction of single strand scission in bacteriophage φX174 replicative form I DNA by mitomycin C ,34,3,317-322 1981 英語 公開
K. Ueda; J. Morita; K. Yamashita; T. Komano K. Ueda; J. Morita; K. Yamashita; T. Komano Inactivation of bacteriophage øX174 by mitomycin C in the presence of sodium hydrosulfite and cupric ions Inactivation of bacteriophage øX174 by mitomycin C in the presence of sodium hydrosulfite and cupric ions ,29,2,145-158 1980 英語 公開

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タイトル言語:
書籍等出版物
著者 著者(日本語) 著者(英語) タイトル タイトル(日本語) タイトル(英語) 出版社 出版年月 記述言語 担当区分 公開
植田 和光 植田 和光 ABCトランスポーター-生体防御のABC-遺伝子から疾患まで. ABCトランスポーター-生体防御のABC-遺伝子から疾患まで. 診断と治療社, 2002 日本語 公開
植田 和光 植田 和光 ガン細胞の薬剤耐性機構 ガン細胞の薬剤耐性機構 In動物細胞細胞工学ハンドブック:朝倉書店, 2001 日本語 公開
植田 和光 植田 和光 MDR1遺伝子を介した多剤耐性.In癌の薬剤耐性とその克服-基礎と臨床,大沼尚夫,and竹村譲eds. MDR1遺伝子を介した多剤耐性.In癌の薬剤耐性とその克服-基礎と臨床,大沼尚夫,and竹村譲eds. 宇宙堂八木書店,/,63-72 2001 日本語 公開
植田 和光 植田 和光 Cell volume regulation. The molecular mechanism and volume sensing machinery. (共著) Cell volume regulation. The molecular mechanism and volume sensing machinery. (共著) Volume sesor anion channel., 1998 日本語 公開
植田 和光 植田 和光 How does P-gp recognize its substrates? (共著) How does P-gp recognize its substrates? (共著) Seminars in Cancer Biology, 1997 日本語 公開
植田 和光 植田 和光 多剤耐性の分子機構 多剤耐性の分子機構 羊土社 1994 日本語 公開
植田 和光 植田 和光 脂溶性酸化物のDNA損傷作用及び脂溶性有害物質排出ポンプPー糖蛋白質(共著) 脂溶性酸化物のDNA損傷作用及び脂溶性有害物質排出ポンプPー糖蛋白質(共著) 食品の生体調節機能,/,319-330 1993 日本語 公開
植田 和光 植田 和光 ABCタンパク質:細胞のATPエンジン.In生体膜のエネルギー装置 ABCタンパク質:細胞のATPエンジン.In生体膜のエネルギー装置 バイオサイエンスの新世紀 共立出版,7 日本語 公開
植田 和光 植田 和光 Role of P-glycoprotein in the transport of hormones and peptides. Role of P-glycoprotein in the transport of hormones and peptides. Multidrug resistance in cancer cells. (共著), 1996 英語 公開
植田 和光 植田 和光 Substrates for P-glycoprotein in kidney Substrates for P-glycoprotein in kidney Transports in the liver (共著),/,223-232 1994 英語 公開
タイトル言語:
学術賞等
賞の名称(日本語) 賞の名称(英語) 授与組織名(日本語) 授与組織名(英語) 年月
日本農芸化学会奨励賞 日本農芸化学会 1992
日本農芸化学会賞 日本農芸化学会 2010/03
外部資金:競争的資金・科学研究費補助金
種別 代表/分担 テーマ(日本語) テーマ(英語) 期間
基盤研究(S) 代表 脂質輸送に関与するABC蛋白質の生理的基質と機能の解明
基盤研究(S) 脂質輸送に関与するABC蛋白質の生理的基質と機能の解明 2008〜2012
基盤研究(A) 代表 HDL(善玉コレステロール)形成の鍵をにぎるABC蛋白質の作用機構解明 2013〜2015
基盤研究(S) 代表 コレステロール恒常性の鍵をにぎるABC蛋白質の作用機構解明 2013〜2017
基盤研究(S) 代表 コレステロール恒常性の鍵をにぎるABC蛋白質の作用機構解明 (平成26年度分) 2014/04/01〜2015/03/31
基盤研究(S) 代表 コレステロール恒常性の鍵をにぎるABC蛋白質の作用機構解明 (平成27年度分) 2015/04/01〜2016/03/31
外部資金:競争的資金・科学研究費補助金以外
制度名 代表者名 研究課題(日本語) 研究課題(英語) 期間
抗癌剤排出ポンプP-糖蛋白質の作用メカニズムの解明 Molecular mechanism of multidrug transporter P-glycoprotein
ATP感受性K<sup>+</sup>チャンネルの分子メカニズム Molecular mechanism of ATP sensitine K<sup>+</sup> channel
ABCタンパク質の分子メカニズム Molecular mechanism of ABC proteins
脂質ホメオスタシスに関与するABC蛋白質の分子基盤
担当科目
講義名(日本語) 講義名(英語) 開講期 学部/研究科 年度
応用生命科学入門III 後期 農学部 2011/04〜2012/03
分子生物学II 後期 農学部 2011/04〜2012/03
細胞生化学専攻実験 農学研究科 2011/04〜2012/03
細胞生化学専攻演習 農学研究科 2011/04〜2012/03
応用生命科学 Applied Life Sciences 後期 全学共通科目 2011/04〜2012/03
分子生物学Ⅱ Molecular BiologyII 後期 農学部 2012/04〜2013/03
応用生命科学 Applied Life Sciences 後期 全学共通科目 2012/04〜2013/03
応用生命科学入門III Introduction to Applied Life Science III 後期 農学部 2012/04〜2013/03
細胞と物質をつなぐ科学 Integrated Cell-Material Sciences 後期 全学共通科目 2012/04〜2013/03
応用生命科学入門III Introduction to Applied Life Science III 後期 農学部 2013/04〜2014/03
分子生物学Ⅱ Molecular BiologyII 後期 農学部 2013/04〜2014/03
応用生命科学 III Applied Life Sciences III 前期集中 農学研究科 2013/04〜2014/03
細胞生化学講義 Cellular Biochemistry 後期集中 農学研究科 2013/04〜2014/03
細胞生化学専攻演習 Cellular Biochemistry Seminar 通年 農学研究科 2013/04〜2014/03
細胞生化学専攻実験 Experimental Course of Cellular Biochemistry 通年 農学研究科 2013/04〜2014/03
応用生命科学 Applied Life Sciences 後期 全学共通科目 2013/04〜2014/03
細胞と物質をつなぐ科学 Integrated Cell-Material Sciences 後期 全学共通科目 2013/04〜2014/03
応用生命科学入門III Introduction to Applied Life Science III 後期 農学部 2014/04〜2015/03
分子生物学Ⅱ Molecular BiologyII 後期 農学部 2014/04〜2015/03
応用生命科学 III Applied Life Sciences III 前期集中 農学研究科 2014/04〜2015/03
細胞生化学講義 Cellular Biochemistry 前期集中 農学研究科 2014/04〜2015/03
Advanced Applied Biochemistry Advanced Applied Biochemistry 後期集中 農学研究科 2014/04〜2015/03
細胞生化学専攻演習 Cellular Biochemistry Seminar 通年 農学研究科 2014/04〜2015/03
細胞生化学専攻実験 Experimental Course of Cellular Biochemistry 通年 農学研究科 2014/04〜2015/03
応用生命科学 Applied Life Sciences 後期 全学共通科目 2014/04〜2015/03
細胞と物質をつなぐ科学 Integrated Cell-Material Sciences 後期 全学共通科目 2014/04〜2015/03
分子生物学Ⅱ Molecular BiologyII 後期 農学部 2015/04〜2016/03
応用生命科学 III Applied Life Sciences III 前期集中 農学研究科 2015/04〜2016/03
応用生命科学入門III Introduction to Applied Life Science III 後期 農学部 2015/04〜2016/03
細胞と物質をつなぐ科学 Integrated Cell-Material Sciences 後期 全学共通科目 2015/04〜2016/03
細胞生化学専攻実験1 Experimental Course of Cellular Biochemistry1 通年 農学研究科 2015/04〜2016/03
細胞生化学専攻実験 Experimental Course of Cellular Biochemistry 通年 農学研究科 2015/04〜2016/03
細胞生化学専攻演習1 Cellular Biochemistry Seminar1 通年 農学研究科 2015/04〜2016/03
細胞生化学専攻演習 Cellular Biochemistry Seminar 通年 農学研究科 2015/04〜2016/03
細胞生化学講義 Cellular Biochemistry 前期集中 農学研究科 2015/04〜2016/03
Advanced Applied Biochemistry Advanced Applied Biochemistry 後期集中 農学研究科 2016/04〜2017/03
分子生物学Ⅱ Molecular BiologyII 後期 農学部 2016/04〜2017/03
応用生命科学 III Applied Life Sciences III 前期集中 農学研究科 2016/04〜2017/03
細胞生化学専攻実験1 Experimental Course of Cellular Biochemistry1 通年 農学研究科 2016/04〜2017/03
細胞生化学専攻実験2 Experimental Course of Cellular Biochemistry2 通年 農学研究科 2016/04〜2017/03
細胞生化学専攻実験 Experimental Course of Cellular Biochemistry 通年 農学研究科 2016/04〜2017/03
細胞生化学専攻演習1 Cellular Biochemistry Seminar1 通年 農学研究科 2016/04〜2017/03
細胞生化学専攻演習2 Cellular Biochemistry Seminar2 通年 農学研究科 2016/04〜2017/03
細胞生化学専攻演習 Cellular Biochemistry Seminar 通年 農学研究科 2016/04〜2017/03
細胞生化学講義 Cellular Biochemistry 前期集中 農学研究科 2016/04〜2017/03

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部局運営(役職等)
役職名 期間
PI議長 2014/04/01〜2015/03/31
農学研究科学部教務委員会 委員 2016/04/01〜2018/03/31
農学研究科研究活動推進委員会 委員 2016/04/01〜2018/03/31
学会活動:学会役員歴
学会名(日本語) 学会名(英語) 役職名(日本語) 役職名(英語) 期間
日本農芸化学会 会長 President 2015/05/01〜2017/04/30
日本癌学会 評議員
日本生化学会 常任理事 2008/04/01〜2010/03/31
学会活動:編集委員歴
学会名(日本語) 学会名(英語) ジャーナル名(日本語) ジャーナル名(英語) 役職名 期間
日本農芸化学会 Japan Society forBioscience, Biotechnology, and Agrochemistry Bioscience Biotechnology and Biochemistry Bioscience Biotechnology and Biochemistry 編集委員長 2013/05/01〜2014/12/31
その他活動:国・地方公共団体での活動
委員会名(日本語) 委員会名(英語) 役職名 公共団体の名称 期間
学術システム研究センター 主任研究員 日本学術振興会 2015/04/01〜2018/03/31