岡田 徹也

Last Update: 2018/06/29 18:45:02

Print

Name(Kanji/Kana/Abecedarium Latinum)
岡田 徹也/オカダ テツヤ/Tetsuya Okada
Primary department(Org1/Job title)
Graduate Schools Science/Assistant Professor
Faculty
Org1 Job title
理学部
Contact address
Type Address(Japanese) Address(English)
Office 〒606-8502 京都府京都市左京区追分町 Kitashirakawa-Oiwake, Sakyo-ku, Kyoto 606-8502, Japan
Affiliated academic organization(s) (Japanese)
Organization name(Japanese) Organization name(English)
日本生化学会 The Japanese Biochemical Society
日本分子生物学会 The Molecular Biology Society of Japan
日本細胞生物学会 Japan Society for Cell Biology
Academic degree
Field(Japanese) Field(English) University(Japanese) University(English) Method
修士(生命科学) 京都大学
博士(生命科学) 京都大学
Graduate school
University(Japanese) University(English) Faculty(Japanese) Faculty(English) Major(Japanese) Major(English) Degree
京都大学 大学院生命科学研究科博士後期課程高次生命科学専攻 修了
京都大学 大学院生命科学研究科修士課程高次生命科学専攻 修了
University
University(Japanese) University(English) Faculty(Japanese) Faculty(English) Major(s)(Japanese) Major(s)(English) Degree
京都大学 農学部生物生産科学科 卒業
Work Experience
Period Organization(Japanese) Organization(English) Job title(Japanese) Job title(English)
- 2004- 京都大学大学院理学研究科 助手 2004- Instructor, Graduate School of Science, Kyoto University
- 2007- 京都大学大学院理学研究科 助教 2007- Assistant Professor, Graduate School of Science, Kyoto University
Research Topics
(Japanese)
小胞体におけるタンパク質の品質管理機構と恒常性維持
(English)
mechanism of protein quality control and homeostasis in the endoplasmic reticulum
Overview of your research
(Japanese)
新しく合成された膜タンパク質や分泌タンパク質は、小胞体で正しい高次構造を獲得したのち、それぞれの最終目的地へ輸送される。このようなタンパク質の品質管理を担うのが、分子シャペロンなどによる高次構造形成促進と、構造異常タンパク質の分解である。私はこれらのシステムが種々の生理的病理的環境に応じて増強される分子機構の解析を行っている。
(English)
The endoplasmic reticulum (ER) provides an environment for the folding of newly synthesized secretory and membrane proteins, and is responsible for protein quality control, whereby only properly folded proteins are delivered to their final destinations. The ER possesses two systems for protein quality control, (1) the protein folding assisted by molecular chaperons and (2) the degradation of misfolded proteins. My research interest is molecular mechanisms for regulating the capacity of these systems in response to physiological or pathological stress conditions.
Fields of research (key words)
Key words(Japanese) Key words(English)
小胞体ストレス ER stress
タンパク質の品質管理 Quality Control
Fields of research (kaken code)
Kaken code
Cell biology
Functional biochemistry
Published Papers
Author Author(Japanese) Author(English) Title Title(Japanese) Title(English) Bibliography Bibliography(Japanese) Bibliography(English) Publication date Refereed paper Language Publishing type Disclose
T. Ishikawa, T. Toyama, Y. Nakamura, K. Tamada, H. Shimizu, S. Ninagawa, T. Okada, Y. Kamei, T. Ishikawa-Fujiwara,  T. Todo, E. Aoyama, M. Takigawa,  A. Harada and K. Mori T. Ishikawa, T. Toyama, Y. Nakamura, K. Tamada, H. Shimizu, S. Ninagawa, T. Okada, Y. Kamei, T. Ishikawa-Fujiwara,  T. Todo, E. Aoyama, M. Takigawa,  A. Harada and K. Mori T. Ishikawa, T. Toyama, Y. Nakamura, K. Tamada, H. Shimizu, S. Ninagawa, T. Okada, Y. Kamei, T. Ishikawa-Fujiwara,  T. Todo, E. Aoyama, M. Takigawa,  A. Harada and K. Mori UPR transducer BBF2H7 allows export of type II collagen in a cargo- and developmental stage-specific manner. UPR transducer BBF2H7 allows export of type II collagen in a cargo- and developmental stage-specific manner. UPR transducer BBF2H7 allows export of type II collagen in a cargo- and developmental stage-specific manner. The Journal of Cell Biology, 216, 6, 1761-1774 The Journal of Cell Biology, 216, 6, 1761-1774 The Journal of Cell Biology, 216, 6, 1761-1774 2017/05 Refereed English Research paper(scientific journal) Disclose to all
S. Ninagawa, T. Okada, Y. Sumitomo, S. Horimoto, T. Sugimoto, T. Ishikawa, S. Takeda, T. Yamamoto, T. Suzuki, Y. Kamiya, K. Kato and K. Mori S. Ninagawa, T. Okada, Y. Sumitomo, S. Horimoto, T. Sugimoto, T. Ishikawa, S. Takeda, T. Yamamoto, T. Suzuki, Y. Kamiya, K. Kato and K. Mori S. Ninagawa, T. Okada, Y. Sumitomo, S. Horimoto, T. Sugimoto, T. Ishikawa, S. Takeda, T. Yamamoto, T. Suzuki, Y. Kamiya, K. Kato and K. Mori Forcible destruction of severely misfolded mammalian glycoproteins by the non-glycoprotein ERAD pathway. Forcible destruction of severely misfolded mammalian glycoproteins by the non-glycoprotein ERAD pathway. Forcible destruction of severely misfolded mammalian glycoproteins by the non-glycoprotein ERAD pathway. The Journal of Cell Biology, 211, 775-784 The Journal of Cell Biology, 211, 775-784 The Journal of Cell Biology, 211, 775-784 2015 Refereed English Research paper(scientific journal) Disclose to all
S. Ninagawa, T. Okada, Y. Sumitomo, Y. Kamiya, K. Kato, S. Horimoto, T. Ishikawa, S. Takeda, T. Sakuma, T. Yamamoto and K. Mori S. Ninagawa, T. Okada, Y. Sumitomo, Y. Kamiya, K. Kato, S. Horimoto, T. Ishikawa, S. Takeda, T. Sakuma, T. Yamamoto and K. Mori S. Ninagawa, T. Okada, Y. Sumitomo, Y. Kamiya, K. Kato, S. Horimoto, T. Ishikawa, S. Takeda, T. Sakuma, T. Yamamoto and K. Mori EDEM2 initiates mammalian glycoprotein ERAD by catalyzing the first mannose trimming step. EDEM2 initiates mammalian glycoprotein ERAD by catalyzing the first mannose trimming step. EDEM2 initiates mammalian glycoprotein ERAD by catalyzing the first mannose trimming step. The Journal of Cell Biology, 206, 347-356 The Journal of Cell Biology, 206, 347-356 The Journal of Cell Biology, 206, 347-356 2015 Refereed English Research paper(scientific journal) Disclose to all
T. Ishikawa; T. Okada; T. Ishikawa-Fujiwara; T. Todo; Y. Kamei; S. Shigenobu; M. Tanaka; T.L. Saito; J. Yoshimura; S. Morishita; A. Toyoda; Y. Sakaki; Y. Taniguchi; S. Takeda; K. Mori T. Ishikawa; T. Okada; T. Ishikawa-Fujiwara; T. Todo; Y. Kamei; S. Shigenobu; M. Tanaka; T.L. Saito; J. Yoshimura; S. Morishita; A. Toyoda; Y. Sakaki; Y. Taniguchi; S. Takeda; K. Mori T. Ishikawa; T. Okada; T. Ishikawa-Fujiwara; T. Todo; Y. Kamei; S. Shigenobu; M. Tanaka; T.L. Saito; J. Yoshimura; S. Morishita; A. Toyoda; Y. Sakaki; Y. Taniguchi; S. Takeda; K. Mori ATF6α/β-mediated adjustment of ER chaperone levels is essential for development of the notochord in medaka fish ATF6α/β-mediated adjustment of ER chaperone levels is essential for development of the notochord in medaka fish ATF6α/β-mediated adjustment of ER chaperone levels is essential for development of the notochord in medaka fish Molecular Biology of the Cell, 24, 9, 1387-1395 Molecular Biology of the Cell, 24, 9, 1387-1395 Molecular Biology of the Cell, 24, 9, 1387-1395 2013/05 Refereed Japanese Research paper(scientific journal) Disclose to all
R. Ozasa; T. Okada; S. Nadanaka; T. Nagamine; A. Zyryanova; H. Harding; D. Ron; K. Mori R. Ozasa; T. Okada; S. Nadanaka; T. Nagamine; A. Zyryanova; H. Harding; D. Ron; K. Mori R. Ozasa; T. Okada; S. Nadanaka; T. Nagamine; A. Zyryanova; H. Harding; D. Ron; K. Mori The antipsychotic olanzapine induces apoptosis in insulin-secreting pancreatic β cells by blocking perk-mediated translational attenuation The antipsychotic olanzapine induces apoptosis in insulin-secreting pancreatic β cells by blocking perk-mediated translational attenuation The antipsychotic olanzapine induces apoptosis in insulin-secreting pancreatic β cells by blocking perk-mediated translational attenuation Cell Structure and Function, 38, 2, 183-194 Cell Structure and Function, 38, 2, 183-194 Cell Structure and Function, 38, 2, 183-194 2013 Refereed Japanese Research paper(scientific journal) Disclose to all
S. Horimoto; S. Ninagawa; T. Okada; H. Koba; T. Sugimoto; Y. Kamiya; K. Kato; S. Takeda; K. Mori S. Horimoto; S. Ninagawa; T. Okada; H. Koba; T. Sugimoto; Y. Kamiya; K. Kato; S. Takeda; K. Mori S. Horimoto; S. Ninagawa; T. Okada; H. Koba; T. Sugimoto; Y. Kamiya; K. Kato; S. Takeda; K. Mori The unfolded protein response transducer ATF6 represents a novel transmembrane-type endoplasmic reticulum-associated degradation substrate requiring both mannose trimming and SEL1L protein The unfolded protein response transducer ATF6 represents a novel transmembrane-type endoplasmic reticulum-associated degradation substrate requiring both mannose trimming and SEL1L protein The unfolded protein response transducer ATF6 represents a novel transmembrane-type endoplasmic reticulum-associated degradation substrate requiring both mannose trimming and SEL1L protein Journal of Biological Chemistry, 288, 44, 31517-31527 Journal of Biological Chemistry, 288, 44, 31517-31527 Journal of Biological Chemistry, 288, 44, 31517-31527 2013 Refereed English Research paper(scientific journal) Disclose to all
J.M. Lynch; M. Maillet; D. Vanhoutte; A. Schloemer; M.A. Sargent; N.S. Blair; K.A. Lynch; T. Okada; B.J. Aronow; H. Osinska; R. Prywes; J.N. Lorenz; K. Mori; J. Lawler; J. Robbins; J.D. Molkentin J.M. Lynch; M. Maillet; D. Vanhoutte; A. Schloemer; M.A. Sargent; N.S. Blair; K.A. Lynch; T. Okada; B.J. Aronow; H. Osinska; R. Prywes; J.N. Lorenz; K. Mori; J. Lawler; J. Robbins; J.D. Molkentin J.M. Lynch; M. Maillet; D. Vanhoutte; A. Schloemer; M.A. Sargent; N.S. Blair; K.A. Lynch; T. Okada; B.J. Aronow; H. Osinska; R. Prywes; J.N. Lorenz; K. Mori; J. Lawler; J. Robbins; J.D. Molkentin A thrombospondin-dependent pathway for a protective ER stress response A thrombospondin-dependent pathway for a protective ER stress response A thrombospondin-dependent pathway for a protective ER stress response Cell, 149, 6, 1257-1268 Cell, 149, 6, 1257-1268 Cell, 149, 6, 1257-1268 2012/06 Refereed English Research paper(scientific journal) Disclose to all
P. Gade; G. Ramachandran; U.B. Maachani; M.A. Rizzo; T. Okada; R. Prywes; A.S. Cross; K. Mori; D.V. Kalvakolanu P. Gade; G. Ramachandran; U.B. Maachani; M.A. Rizzo; T. Okada; R. Prywes; A.S. Cross; K. Mori; D.V. Kalvakolanu P. Gade; G. Ramachandran; U.B. Maachani; M.A. Rizzo; T. Okada; R. Prywes; A.S. Cross; K. Mori; D.V. Kalvakolanu An IFN-γ-stimulated ATF6-C/EBP-β-signaling pathway critical for the expression of death associated protein kinase 1 and induction of autophagy An IFN-γ-stimulated ATF6-C/EBP-β-signaling pathway critical for the expression of death associated protein kinase 1 and induction of autophagy An IFN-γ-stimulated ATF6-C/EBP-β-signaling pathway critical for the expression of death associated protein kinase 1 and induction of autophagy Proceedings of the National Academy of Sciences of the United States of America, 109, 26, 10316-10321 Proceedings of the National Academy of Sciences of the United States of America, 109, 26, 10316-10321 Proceedings of the National Academy of Sciences of the United States of America, 109, 26, 10316-10321 2012 Refereed English Research paper(scientific journal) Disclose to all
Y. Sato; S. Nadanaka; T. Okada; K. Okawa; K. Mori Y. Sato; S. Nadanaka; T. Okada; K. Okawa; K. Mori Y. Sato; S. Nadanaka; T. Okada; K. Okawa; K. Mori Luminal domain of ATF6 alone is sufficient for sensing endoplasmic reticulum stress and subsequent transport to the Golgi apparatus Luminal domain of ATF6 alone is sufficient for sensing endoplasmic reticulum stress and subsequent transport to the Golgi apparatus Luminal domain of ATF6 alone is sufficient for sensing endoplasmic reticulum stress and subsequent transport to the Golgi apparatus Cell Structure and Function, 36, 1, 35-47 Cell Structure and Function, 36, 1, 35-47 Cell Structure and Function, 36, 1, 35-47 2011 Refereed English Research paper(scientific journal) Disclose to all
S. Ninagawa; T. Okada; S. Takeda; K. Mori S. Ninagawa; T. Okada; S. Takeda; K. Mori S. Ninagawa; T. Okada; S. Takeda; K. Mori SEL1L is required for endoplasmic reticulum-associated degradation of misfolded luminal proteins but not transmembrane proteins in chicken DT40 cell line. SEL1L is required for endoplasmic reticulum-associated degradation of misfolded luminal proteins but not transmembrane proteins in chicken DT40 cell line. SEL1L is required for endoplasmic reticulum-associated degradation of misfolded luminal proteins but not transmembrane proteins in chicken DT40 cell line. Cell structure and function, 36, 2, 187-195 Cell structure and function, 36, 2, 187-195 Cell structure and function, 36, 2, 187-195 2011 Refereed English Research paper(scientific journal) Disclose to all
T. Ishikawa; Y. Taniguchi; T. Okada; S. Takeda; K. Mori T. Ishikawa; Y. Taniguchi; T. Okada; S. Takeda; K. Mori T. Ishikawa; Y. Taniguchi; T. Okada; S. Takeda; K. Mori Vertebrate unfolded protein response: mammalian signaling pathways are conserved in Medaka fish. Vertebrate unfolded protein response: mammalian signaling pathways are conserved in Medaka fish. Vertebrate unfolded protein response: mammalian signaling pathways are conserved in Medaka fish. Cell structure and function, 36, 2, 247-259 Cell structure and function, 36, 2, 247-259 Cell structure and function, 36, 2, 247-259 2011 Refereed English Research paper(scientific journal) Disclose to all
K. Yamamoto; K. Takahara; S. Oyadomari; T. Okada; T. Sato; A. Harada; K. Mori K. Yamamoto; K. Takahara; S. Oyadomari; T. Okada; T. Sato; A. Harada; K. Mori K. Yamamoto; K. Takahara; S. Oyadomari; T. Okada; T. Sato; A. Harada; K. Mori Induction of liver steatosis and lipid droplet formation in ATF6α-knockout mice burdened with pharmacological endoplasmic reticulum stress Induction of liver steatosis and lipid droplet formation in ATF6α-knockout mice burdened with pharmacological endoplasmic reticulum stress Induction of liver steatosis and lipid droplet formation in ATF6α-knockout mice burdened with pharmacological endoplasmic reticulum stress Molecular Biology of the Cell, 21, 17, 2975-2986 Molecular Biology of the Cell, 21, 17, 2975-2986 Molecular Biology of the Cell, 21, 17, 2975-2986 2010/09 Refereed English Research paper(scientific journal) Disclose to all
T. Uemura; T. Sato; T. Aoki; A. Yamamoto; T. Okada; R. Hirai; R. Harada; K. Mori; M. Tagaya; A. Harada T. Uemura; T. Sato; T. Aoki; A. Yamamoto; T. Okada; R. Hirai; R. Harada; K. Mori; M. Tagaya; A. Harada T. Uemura; T. Sato; T. Aoki; A. Yamamoto; T. Okada; R. Hirai; R. Harada; K. Mori; M. Tagaya; A. Harada p31 deficiency influences endoplasmic reticulum tubular morphology and cell survival p31 deficiency influences endoplasmic reticulum tubular morphology and cell survival p31 deficiency influences endoplasmic reticulum tubular morphology and cell survival Molecular and Cellular Biology, 29, 7, 1869-1881 Molecular and Cellular Biology, 29, 7, 1869-1881 Molecular and Cellular Biology, 29, 7, 1869-1881 2009/04 Refereed English Research paper(scientific journal) Disclose to all
K. Yamamoto; N. Suzuki; T. Wada; T. Okada; H. Yoshida; R.J. Kaufman; K. Mori K. Yamamoto; N. Suzuki; T. Wada; T. Okada; H. Yoshida; R.J. Kaufman; K. Mori K. Yamamoto; N. Suzuki; T. Wada; T. Okada; H. Yoshida; R.J. Kaufman; K. Mori Human HRD1 promoter carries a functional unfolded protein response element to which XBP1 but not ATF6 directly binds Human HRD1 promoter carries a functional unfolded protein response element to which XBP1 but not ATF6 directly binds Human HRD1 promoter carries a functional unfolded protein response element to which XBP1 but not ATF6 directly binds Journal of Biochemistry, 144, 4, 477-486 Journal of Biochemistry, 144, 4, 477-486 Journal of Biochemistry, 144, 4, 477-486 2008/10 Refereed English Research paper(scientific journal) Disclose to all
Y. Adachi; K. Yamamoto; T. Okada; H. Yoshida; A. Harada; K. Mori Y. Adachi; K. Yamamoto; T. Okada; H. Yoshida; A. Harada; K. Mori Y. Adachi; K. Yamamoto; T. Okada; H. Yoshida; A. Harada; K. Mori ATF6 is a transcription factor specializing in the regulation of quality control proteins in the endoplasmic reticulum ATF6 is a transcription factor specializing in the regulation of quality control proteins in the endoplasmic reticulum ATF6 is a transcription factor specializing in the regulation of quality control proteins in the endoplasmic reticulum Cell Structure and Function, 33, 1, 75-89 Cell Structure and Function, 33, 1, 75-89 Cell Structure and Function, 33, 1, 75-89 2008 Refereed Japanese Research paper(scientific journal) Disclose to all
K. Yamamoto; T. Sato; T. Matsui; M. Sato; T. Okada; H. Yoshida; A. Harada; K. Mori K. Yamamoto; T. Sato; T. Matsui; M. Sato; T. Okada; H. Yoshida; A. Harada; K. Mori K. Yamamoto; T. Sato; T. Matsui; M. Sato; T. Okada; H. Yoshida; A. Harada; K. Mori Transcriptional Induction of Mammalian ER Quality Control Proteins Is Mediated by Single or Combined Action of ATF6α and XBP1 Transcriptional Induction of Mammalian ER Quality Control Proteins Is Mediated by Single or Combined Action of ATF6α and XBP1 Transcriptional Induction of Mammalian ER Quality Control Proteins Is Mediated by Single or Combined Action of ATF6α and XBP1 Developmental Cell, 13, 3, 365-376 Developmental Cell, 13, 3, 365-376 Developmental Cell, 13, 3, 365-376 2007/09 Refereed English Research paper(scientific journal) Disclose to all
S. Nadanaka; T. Okada; H. Yoshida; K. Mori S. Nadanaka; T. Okada; H. Yoshida; K. Mori S. Nadanaka; T. Okada; H. Yoshida; K. Mori Role of disulfide bridges formed in the luminal domain of ATF6 in sensing endoplasmic reticulum stress Role of disulfide bridges formed in the luminal domain of ATF6 in sensing endoplasmic reticulum stress Role of disulfide bridges formed in the luminal domain of ATF6 in sensing endoplasmic reticulum stress Molecular and Cellular Biology, 27, 3, 1027-1043 Molecular and Cellular Biology, 27, 3, 1027-1043 Molecular and Cellular Biology, 27, 3, 1027-1043 2007/02 Refereed English Research paper(scientific journal) Disclose to all
Y. Oda; T. Okada; H. Yoshida; R.J. Kaufman; K. Nagata; K. Mori Y. Oda; T. Okada; H. Yoshida; R.J. Kaufman; K. Nagata; K. Mori Y. Oda; T. Okada; H. Yoshida; R.J. Kaufman; K. Nagata; K. Mori Derlin-2 and Derlin-3 are regulated by the mammalian unfolded protein response and are required for ER-associated degradation Derlin-2 and Derlin-3 are regulated by the mammalian unfolded protein response and are required for ER-associated degradation Derlin-2 and Derlin-3 are regulated by the mammalian unfolded protein response and are required for ER-associated degradation Journal of Cell Biology, 172, 3, 383-393 Journal of Cell Biology, 172, 3, 383-393 Journal of Cell Biology, 172, 3, 383-393 2006/01 Refereed English Research paper(scientific journal) Disclose to all
M. Flores-Diaz; J.-C. Higuita; I. Florin; T. Okada; P. Pollesello; T. Bergman; M. Thelestam; K. Mori; A. Alape-Giron M. Flores-Diaz; J.-C. Higuita; I. Florin; T. Okada; P. Pollesello; T. Bergman; M. Thelestam; K. Mori; A. Alape-Giron M. Flores-Diaz; J.-C. Higuita; I. Florin; T. Okada; P. Pollesello; T. Bergman; M. Thelestam; K. Mori; A. Alape-Giron A cellular UDP-glucose deficiency causes overexpression of glucose/oxygen-regulated proteins independent of the endoplasmic reticulum stress elements A cellular UDP-glucose deficiency causes overexpression of glucose/oxygen-regulated proteins independent of the endoplasmic reticulum stress elements A cellular UDP-glucose deficiency causes overexpression of glucose/oxygen-regulated proteins independent of the endoplasmic reticulum stress elements Journal of Biological Chemistry, 279, 21, 21724-21731 Journal of Biological Chemistry, 279, 21, 21724-21731 Journal of Biological Chemistry, 279, 21, 21724-21731 2004/05 Refereed English Research paper(scientific journal) Disclose to all
T. Okada; K. Haze; S. Nadanaka; H. Yoshida; N.G. Seidah; Y. Hirano; R. Sato; M. Negishi; K. Mori T. Okada; K. Haze; S. Nadanaka; H. Yoshida; N.G. Seidah; Y. Hirano; R. Sato; M. Negishi; K. Mori T. Okada; K. Haze; S. Nadanaka; H. Yoshida; N.G. Seidah; Y. Hirano; R. Sato; M. Negishi; K. Mori A serine protease inhibitor prevents endoplasmic reticulum stress-induced cleavage but not transport of the membrane-bound transcription factor ATF6 A serine protease inhibitor prevents endoplasmic reticulum stress-induced cleavage but not transport of the membrane-bound transcription factor ATF6 A serine protease inhibitor prevents endoplasmic reticulum stress-induced cleavage but not transport of the membrane-bound transcription factor ATF6 Journal of Biological Chemistry, 278, 33, 31024-31032 Journal of Biological Chemistry, 278, 33, 31024-31032 Journal of Biological Chemistry, 278, 33, 31024-31032 2003/08 Refereed English Research paper(scientific journal) Disclose to all
M. Shuda; N. Kondoh; N. Imazeki; K. Tanaka; T. Okada; K. Mori; A. Hada; M. Arai; T. Wakatsuki; O. Matsubara; N. Yamamoto; M. Yamamoto M. Shuda; N. Kondoh; N. Imazeki; K. Tanaka; T. Okada; K. Mori; A. Hada; M. Arai; T. Wakatsuki; O. Matsubara; N. Yamamoto; M. Yamamoto M. Shuda; N. Kondoh; N. Imazeki; K. Tanaka; T. Okada; K. Mori; A. Hada; M. Arai; T. Wakatsuki; O. Matsubara; N. Yamamoto; M. Yamamoto Activation of the ATF6, XBP1 and grp78 genes in human hepatocellular carcinoma: A possible involvement of the ER stress pathway in hepatocarcinogenesis Activation of the ATF6, XBP1 and grp78 genes in human hepatocellular carcinoma: A possible involvement of the ER stress pathway in hepatocarcinogenesis Activation of the ATF6, XBP1 and grp78 genes in human hepatocellular carcinoma: A possible involvement of the ER stress pathway in hepatocarcinogenesis Journal of Hepatology, 38, 5, 605-614 Journal of Hepatology, 38, 5, 605-614 Journal of Hepatology, 38, 5, 605-614 2003/05 Refereed English Research paper(scientific journal) Disclose to all
T. Okada; H. Yoshida; R. Akazawa; M. Negishi; K. Mori T. Okada; H. Yoshida; R. Akazawa; M. Negishi; K. Mori T. Okada; H. Yoshida; R. Akazawa; M. Negishi; K. Mori Distinct roles of activating transcription factor 6 (ATF6) and double-stranded RNA-activated protein kinase-like endoplasmic reticulum kinase (PERK) in transcription during the mammalian unfolded protein response Distinct roles of activating transcription factor 6 (ATF6) and double-stranded RNA-activated protein kinase-like endoplasmic reticulum kinase (PERK) in transcription during the mammalian unfolded protein response Distinct roles of activating transcription factor 6 (ATF6) and double-stranded RNA-activated protein kinase-like endoplasmic reticulum kinase (PERK) in transcription during the mammalian unfolded protein response Biochemical Journal, 366, 2, 585-594 Biochemical Journal, 366, 2, 585-594 Biochemical Journal, 366, 2, 585-594 2002/09 Refereed English Research paper(scientific journal) Disclose to all
K. Lee; W. Tirasophon; X. Shen; M. Michalak; R. Prywes; T. Okada; H. Yoshida; K. Mori; R.J. Kaufman K. Lee; W. Tirasophon; X. Shen; M. Michalak; R. Prywes; T. Okada; H. Yoshida; K. Mori; R.J. Kaufman K. Lee; W. Tirasophon; X. Shen; M. Michalak; R. Prywes; T. Okada; H. Yoshida; K. Mori; R.J. Kaufman IRE1-mediated unconventional mRNA splicing and S2P-mediated ATF6 cleavage merge to regulate XBP1 in signaling the unfolded protein response IRE1-mediated unconventional mRNA splicing and S2P-mediated ATF6 cleavage merge to regulate XBP1 in signaling the unfolded protein response IRE1-mediated unconventional mRNA splicing and S2P-mediated ATF6 cleavage merge to regulate XBP1 in signaling the unfolded protein response Genes and Development, 16, 4 Genes and Development, 16, 4 Genes and Development, 16, 4 2002/02 Refereed English Research paper(scientific journal) Disclose to all
H. Yoshida; T. Matsui; A. Yamamoto; T. Okada; K. Mori H. Yoshida; T. Matsui; A. Yamamoto; T. Okada; K. Mori H. Yoshida; T. Matsui; A. Yamamoto; T. Okada; K. Mori XBP1 mRNA is induced by ATF6 and spliced by IRE1 in response to ER stress to produce a highly active transcription factor XBP1 mRNA is induced by ATF6 and spliced by IRE1 in response to ER stress to produce a highly active transcription factor XBP1 mRNA is induced by ATF6 and spliced by IRE1 in response to ER stress to produce a highly active transcription factor Cell, 107, 7, 881-891 Cell, 107, 7, 881-891 Cell, 107, 7, 881-891 2001/12 Refereed English Research paper(scientific journal) Disclose to all
K. Haze; T. Okada; H. Yoshida; H. Yanagi; T. Yura; M. Negishi; K. Mori K. Haze; T. Okada; H. Yoshida; H. Yanagi; T. Yura; M. Negishi; K. Mori K. Haze; T. Okada; H. Yoshida; H. Yanagi; T. Yura; M. Negishi; K. Mori Identification of the G13 (cAMP-response-element-binding protein-related protein) gene product related to activating transcription factor 6 as a transcriptional activator of the mammalian unfolded protein response Identification of the G13 (cAMP-response-element-binding protein-related protein) gene product related to activating transcription factor 6 as a transcriptional activator of the mammalian unfolded protein response Identification of the G13 (cAMP-response-element-binding protein-related protein) gene product related to activating transcription factor 6 as a transcriptional activator of the mammalian unfolded protein response Biochemical Journal, 355, 1, 19-28 Biochemical Journal, 355, 1, 19-28 Biochemical Journal, 355, 1, 19-28 2001/04 Refereed English Research paper(scientific journal) Disclose to all
H. Yoshida; T. Okada; K. Haze; H. Yanagi; T. Yura; M. Negishi; K. Mori H. Yoshida; T. Okada; K. Haze; H. Yanagi; T. Yura; M. Negishi; K. Mori H. Yoshida; T. Okada; K. Haze; H. Yanagi; T. Yura; M. Negishi; K. Mori Endoplasmic reticulum stress-induced formation of transcription factor complex ERSF including NF-Y (CBF) and activating transcription factors 6α and 6β that activates the mammalian unfolded protein response Endoplasmic reticulum stress-induced formation of transcription factor complex ERSF including NF-Y (CBF) and activating transcription factors 6α and 6β that activates the mammalian unfolded protein response Endoplasmic reticulum stress-induced formation of transcription factor complex ERSF including NF-Y (CBF) and activating transcription factors 6α and 6β that activates the mammalian unfolded protein response Molecular and Cellular Biology, 21, 4, 1239-1248 Molecular and Cellular Biology, 21, 4, 1239-1248 Molecular and Cellular Biology, 21, 4, 1239-1248 2001/02 Refereed English Research paper(scientific journal) Disclose to all
H. Yoshida; T. Okada; K. Haze; H. Yanagi; T. Yura; M. Negishi; K. Mori H. Yoshida; T. Okada; K. Haze; H. Yanagi; T. Yura; M. Negishi; K. Mori H. Yoshida; T. Okada; K. Haze; H. Yanagi; T. Yura; M. Negishi; K. Mori ATF6 activated by proteolysis binds in the presence of NF-Y (CBF) directly to the cis-acting element responsible for the mammalian unfolded protein response ATF6 activated by proteolysis binds in the presence of NF-Y (CBF) directly to the cis-acting element responsible for the mammalian unfolded protein response ATF6 activated by proteolysis binds in the presence of NF-Y (CBF) directly to the cis-acting element responsible for the mammalian unfolded protein response Molecular and Cellular Biology, 20, 18, 6755-6767 Molecular and Cellular Biology, 20, 18, 6755-6767 Molecular and Cellular Biology, 20, 18, 6755-6767 2000/09 Refereed English Research paper(scientific journal) Disclose to all

  • <<
  • >>
Title language:
Misc
Author Author(Japanese) Author(English) Title Title(Japanese) Title(English) Bibliography Bibliography(Japanese) Bibliography(English) Publication date Refereed paper Language Publishing type Disclose
岡田 徹也、蜷川 暁、森 和俊 岡田 徹也、蜷川 暁、森 和俊 糖タンパク質の小胞体関連分解におけるマンノーストリミング機構 糖タンパク質の小胞体関連分解におけるマンノーストリミング機構 生化学, 88, 2, 257-260 生化学, 88, 2, 257-260 , 88, 2, 257-260 2016 Refereed Japanese Disclose to all
Title language:
Conference Activities & Talks
Title Title(Japanese) Title(English) Conference Conference(Japanese) Conference(English) Promotor Promotor(Japanese) Promotor(English) Date Language Assortment Disclose
タンパク質の品質管理を担う小胞体内オルガネラ・ゾーン タンパク質の品質管理を担う小胞体内オルガネラ・ゾーン 日本薬学会 第138年会 日本薬学会 第138年会 2018/03 Japanese Oral presentation(general) Disclose to all
小胞体の恒常性維持における膜結合性転写因子ATF6の役割[Invited] 小胞体の恒常性維持における膜結合性転写因子ATF6の役割 [Invited] 第89回 日本薬理学会年会 年会企画ワークショップ「小胞体ストレス入門」 第89回 日本薬理学会年会 年会企画ワークショップ「小胞体ストレス入門」 2016/03 Japanese Symposium workshop panel(nominated) Disclose to all
The unfolded protein response in chicken DT40 cell line: A novel tool for comprehensive genetic analysis of the mammalian-type unfolded protein response The unfolded protein response in chicken DT40 cell line: A novel tool for comprehensive genetic analysis of the mammalian-type unfolded protein response The unfolded protein response in chicken DT40 cell line: A novel tool for comprehensive genetic analysis of the mammalian-type unfolded protein response FASEB summer research conference FASEB summer research conference FASEB summer research conference 2010 English Poster presentation Disclose to all
Role of XBP1-ATF6 heterodimerization in the mammalian unfolded protein response Role of XBP1-ATF6 heterodimerization in the mammalian unfolded protein response Role of XBP1-ATF6 heterodimerization in the mammalian unfolded protein response Summer Research Conferences-From Unfolded Proteins in the Endoplasmic Reticulum to Desease Summer Research Conferences-From Unfolded Proteins in the Endoplasmic Reticulum to Desease Summer Research Conferences-From Unfolded Proteins in the Endoplasmic Reticulum to Desease 2007/08 English Poster presentation Disclose to all
Darlin-2 and Darlin-3 regulated by mammalian Unfolded Protein Response are required for ER-associated Degradation. Darlin-2 and Darlin-3 regulated by mammalian Unfolded Protein Response are required for ER-associated Degradation. Darlin-2 and Darlin-3 regulated by mammalian Unfolded Protein Response are required for ER-associated Degradation. International Symposium on Life of Proteins, Awaji (Japan), 2005. 10. 30-11.3 International Symposium on Life of Proteins, Awaji (Japan), 2005. 10. 30-11.3 International Symposium on Life of Proteins, Awaji (Japan), 2005. 10. 30-11.3 2005/10/30 English Disclose to all
IRE1-XBP1 経路で制御される新規遺伝子CERD1/Derlin-2 の機能解析 IRE1-XBP1 経路で制御される新規遺伝子CERD1/Derlin-2 の機能解析 第27 回日本分子生物学会大会(2004.12.9. 神戸市) 第27 回日本分子生物学会大会(2004.12.9. 神戸市) 2004 Japanese Disclose to all
CERD, a novel \ncomponent of ER-associated degradation machinery, regulated by the IRE1-XBP1 pathway. CERD, a novel \ncomponent of ER-associated degradation machinery, regulated by the IRE1-XBP1 pathway. CERD, a novel \ncomponent of ER-associated degradation machinery, regulated by the IRE1-XBP1 pathway. FASEB 2004 Summer Reserch Conferences(2004.9.31~8.5. Vermont (USA) FASEB 2004 Summer Reserch Conferences(2004.9.31~8.5. Vermont (USA) FASEB 2004 Summer Reserch Conferences(2004.9.31~8.5. Vermont (USA) 2004 English Disclose to all
Title language:
External funds, competitive funds and Grants-in-Aid for Scientific Research(kaken)
Type Position Title(Japanese) Title(English) Period
特別研究員奨励費DC2 Representative DNAマイクロアレイを用いた哺乳動物小胞体ストレス応答遺伝子の網羅的同定と解析 2003-2003
若手研究(B) Representative 小胞体膜結合性転写因子ATF6の活性化に関与する小胞輸送の分子機構解析 2005-2006
若手研究(B) Representative 小胞体ストレスに応答した膜結合性転写因子ATF6の選択的出芽機構 2007-2008
若手研究(B) Representative 膜結合性転写因子ATF6の小胞体ストレス応答性出芽機構 2009-2010
基盤研究(S) Assignment 遺伝子破壊細胞を使った、化学物質の生物効果をハイスループットに解析するシステム 2010-
基盤研究(C) Representative 小胞体マンノシダーゼEDEMの基質特異性と異常タンパク質選別機構 (平成27年度分) 2015/04/01-2016/03/31
基盤研究(C) Representative 小胞体マンノシダーゼEDEMの基質特異性と異常タンパク質選別機構 (平成28年度分) 2016/04/01-2017/03/31
基盤研究(C) Representative 小胞体マンノシダーゼEDEMの基質特異性と異常タンパク質選別機構 (平成29年度分) 2017/04/01-2018/03/31
Teaching subject(s)
Name(Japanese) Name(English) Term Department Period
生物学実習A (2) 前期 理学部 2011/04-2012/03
生物学セミナ-B (12) 後期 理学部 2011/04-2012/03
生物科学課題研究17 通年 理学部 2011/04-2012/03
生物学セミナ-B Seminars in Biological Science B 後期 理学部 2012/04-2013/03
生物学実習A Laboratory work in Biological Science A 前期 理学部 2012/04-2013/03
生物科学課題研究17 Special Study CourseII(Biological Sciences) 17 通年 理学部 2012/04-2013/03
生物学実習A Laboratory work in Biological Science A 前期 理学部 2013/04-2014/03
生物学セミナ−B Seminars in Biological Science B 後期 理学部 2013/04-2014/03
生物科学課題研究17 Special Study CourseII(Biological Sciences) 17 通年 理学部 2013/04-2014/03
生物学実習A Laboratory work in Biological Science A 前期 理学部 2014/04-2015/03
生物学セミナ-B Seminars in Biological Science B 後期 理学部 2014/04-2015/03
生物科学課題研究17 Special Study CourseII(Biological Sciences) 17 通年 理学部 2014/04-2015/03
ゲノム情報発現学ゼミナールIA Seminar on Expression of Genomic Information IA 前期 理学研究科 2014/04-2015/03
ゲノム情報発現学ゼミナールIB Seminar on Expression of Genomic Information IB 後期 理学研究科 2014/04-2015/03
ゲノム情報発現学ゼミナールIC Seminar on Expression of Genomic Information IC 前期 理学研究科 2014/04-2015/03
ゲノム情報発現学ゼミナールID Seminar on Expression of Genomic Information ID 後期 理学研究科 2014/04-2015/03
ゲノム情報発現学ゼミナールIIA Seminar on Expression of Genomic Information IIA 前期 理学研究科 2014/04-2015/03
ゲノム情報発現学ゼミナールIIB Seminar on Expression of Genomic Information IIB 後期 理学研究科 2014/04-2015/03
ゲノム情報発現学ゼミナールIIC Seminar on Expression of Genomic Information IIC 前期 理学研究科 2014/04-2015/03
ゲノム情報発現学ゼミナールIID Seminar on Expression of Genomic Information IID 後期 理学研究科 2014/04-2015/03
ゲノム情報発現学ゼミナールIA Seminar on Expression of Genomic Information IA 前期 理学研究科 2015/04-2016/03
ゲノム情報発現学ゼミナールIB Seminar on Expression of Genomic Information IB 後期 理学研究科 2015/04-2016/03
ゲノム情報発現学ゼミナールIC Seminar on Expression of Genomic Information IC 前期 理学研究科 2015/04-2016/03
ゲノム情報発現学ゼミナールID Seminar on Expression of Genomic Information ID 後期 理学研究科 2015/04-2016/03
ゲノム情報発現学ゼミナールIIA Seminar on Expression of Genomic Information IIA 前期 理学研究科 2015/04-2016/03
ゲノム情報発現学ゼミナールIIB Seminar on Expression of Genomic Information IIB 後期 理学研究科 2015/04-2016/03
ゲノム情報発現学ゼミナールIIC Seminar on Expression of Genomic Information IIC 前期 理学研究科 2015/04-2016/03
ゲノム情報発現学ゼミナールIID Seminar on Expression of Genomic Information IID 後期 理学研究科 2015/04-2016/03
生物学セミナ-B Seminars in Biological Science B 後期 理学部 2015/04-2016/03
生物学実習A Laboratory work in Biological Science A 前期 理学部 2015/04-2016/03
生物科学課題研究17 Special Study CourseII(Biological Sciences) 17 通年 理学部 2015/04-2016/03
ゲノム情報発現学ゼミナールIA Seminar on Expression of Genomic Information IA 前期 理学研究科 2016/04-2017/03
ゲノム情報発現学ゼミナールIB Seminar on Expression of Genomic Information IB 後期 理学研究科 2016/04-2017/03
ゲノム情報発現学ゼミナールIC Seminar on Expression of Genomic Information IC 前期 理学研究科 2016/04-2017/03
ゲノム情報発現学ゼミナールID Seminar on Expression of Genomic Information ID 後期 理学研究科 2016/04-2017/03
ゲノム情報発現学ゼミナールIIA Seminar on Expression of Genomic Information IIA 前期 理学研究科 2016/04-2017/03
ゲノム情報発現学ゼミナールIIB Seminar on Expression of Genomic Information IIB 後期 理学研究科 2016/04-2017/03
ゲノム情報発現学ゼミナールIIC Seminar on Expression of Genomic Information IIC 前期 理学研究科 2016/04-2017/03
ゲノム情報発現学ゼミナールIID Seminar on Expression of Genomic Information IID 後期 理学研究科 2016/04-2017/03
生物学セミナ-B Seminars in Biological Science B 後期 理学部 2016/04-2017/03
生物学実習A Laboratory work in Biological Science A 前期集中 理学部 2016/04-2017/03
生物科学課題研究17 Special Study CourseII(Biological Sciences) 17 通年 理学部 2016/04-2017/03
ゲノム情報発現学ゼミナールIA Seminar on Expression of Genomic Information IA 前期 理学研究科 2017/04-2018/03
ゲノム情報発現学ゼミナールIB Seminar on Expression of Genomic Information IB 後期 理学研究科 2017/04-2018/03
ゲノム情報発現学ゼミナールIC Seminar on Expression of Genomic Information IC 前期 理学研究科 2017/04-2018/03
ゲノム情報発現学ゼミナールID Seminar on Expression of Genomic Information ID 後期 理学研究科 2017/04-2018/03
ゲノム情報発現学ゼミナールIIA Seminar on Expression of Genomic Information IIA 前期 理学研究科 2017/04-2018/03
ゲノム情報発現学ゼミナールIIB Seminar on Expression of Genomic Information IIB 後期 理学研究科 2017/04-2018/03
ゲノム情報発現学ゼミナールIIC Seminar on Expression of Genomic Information IIC 前期 理学研究科 2017/04-2018/03
ゲノム情報発現学ゼミナールIID Seminar on Expression of Genomic Information IID 後期 理学研究科 2017/04-2018/03
生物学セミナ-B Seminars in Biological Science B 後期 理学部 2017/04-2018/03
生物学実習A Laboratory work in Biological Science A 前期集中 理学部 2017/04-2018/03
生物科学課題研究17 Special Study CourseII(Biological Sciences) 17 通年 理学部 2017/04-2018/03
基礎生物学実験II Experimental Course of Fundamental Biology II 後期集中 理学部 2018/04-2019/03
ゲノム情報発現学ゼミナールIA Seminar on Expression of Genomic Information IA 前期 理学研究科 2018/04-2019/03
ゲノム情報発現学ゼミナールIB Seminar on Expression of Genomic Information IB 後期 理学研究科 2018/04-2019/03
ゲノム情報発現学ゼミナールIC Seminar on Expression of Genomic Information IC 前期 理学研究科 2018/04-2019/03
ゲノム情報発現学ゼミナールID Seminar on Expression of Genomic Information ID 後期 理学研究科 2018/04-2019/03
ゲノム情報発現学ゼミナールIIA Seminar on Expression of Genomic Information IIA 前期 理学研究科 2018/04-2019/03
ゲノム情報発現学ゼミナールIIB Seminar on Expression of Genomic Information IIB 後期 理学研究科 2018/04-2019/03
ゲノム情報発現学ゼミナールIIC Seminar on Expression of Genomic Information IIC 前期 理学研究科 2018/04-2019/03
ゲノム情報発現学ゼミナールIID Seminar on Expression of Genomic Information IID 後期 理学研究科 2018/04-2019/03
生物学セミナ-B Seminars in Biological Science B 後期 理学部 2018/04-2019/03
生物学実習A Laboratory work in Biological Science A 前期集中 理学部 2018/04-2019/03
生物科学課題研究17 Special Study CourseII(Biological Sciences) 17 通年 理学部 2018/04-2019/03

  • <<
  • >>
Faculty management (title, position)
Title Period
理学研究科社会交流室運営委員会委員 2017/04/01-2018/03/31
理学研究科社会交流室運営委員会委員 2016/04/01-2018/03/31
理学研究科国際・社会交流・広報委員会委員 2018/04/01-2019/03/31
理学研究科国際・社会交流・広報委員会 国際交流・奨学生推薦小委員会委員 2018/04/01-2019/03/31