鈴木 雄太

Last Update: 2019/06/19 02:20:05

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Name(Kanji/Kana/Abecedarium Latinum)
鈴木 雄太/スズキ ユウタ/Suzuki, Yuta
Primary Affiliation(Org1/Job title)
The HAKUBI Center for Advanced Research/Program-Specific Assistant Professor
E-mail Address
suzuki.yuta.2m @ kyoto-u.ac.jp
Academic Organizations You are Affiliated to in Japan
Organization name(Japanese) Organization name(English)
日本化学学会 The Chemical Society of Japan
日本蛋白質科学会 Protein Science Society of Japan
Academic Degree
Field(Japanese) Field(English) University(Japanese) University(English) Method
修士(Chemistry) M.S. (Chemistry) ミシガン大学 The University of Michigan, Ann Arbor
博士(Chemistry) Ph.D. (Chemistry) ミシガン大学 The University of Michigan, Ann Arbor
Graduate School
University(Japanese) University(English) Faculty(Japanese) Faculty(English) Major(Japanese) Major(English) Degree
ミシガン大学(米国) 化学学部ケミカルバイオロジー専攻 修了
Personal Profile
(Japanese)
 化学者が「デザイナー」となって思いのままに、タンパク質の機能や構造をデザインしコントロールすることが可能となれば、「必要な時、必要な機能を自発的に発動するバイオナノロボット」が、医薬・バイオテクノロジー分野で活躍する時代もそう遠くないのかもしれません。しかしながら、現行のタンパク質デザインでは、複雑性・多様性を有するタンパク質を人工的に制御する緻密かつ煩雑な技術を必要とするにも関わらず、タンパク質集合体の構造を構築するに留まっています。そこで、私が目標とするのは、タンパク質の特徴を無理矢理制御するのではなく、個々のタンパク質の本来持つ利点を最大限利用する新しい「タンパク質デザイン工学」を確立し、将来的に「バイオナノロボット」の創成を目指した研究を推進していきます。
(English)
The ability of chemists to act as "designers" to modify protein structure and functions using a combination of rationale design and directed evolution has the potential to usher in the new era allowing the development of “smart bionanorobots programmed to perform multiple tasks for biotechnology applications”. Such "protein nanorobots" could play active roles in the field of medicine and biotechnology, and development of this technology may not be far away. However, existing protein designs require advanced techniques in order to control the diversity and complexity of protein structures. Therefore, the probability of such success is still low, and many trials-and-errors are required. So far, only primitive construction of protein assembly has been achieved. For this reason, I propose to conduct research to establish “new protein design and engineering methodology” that maximizes the actual and natural characteristics of protein targets toward creating “smart bionanorobots”, rather than forcefully controlling such potentials and characteristics.
researchmap URL
https://researchmap.jp/7000025212
Published Papers
Author Author(Japanese) Author(English) Title Title(Japanese) Title(English) Bibliography Bibliography(Japanese) Bibliography(English) Publication date Refereed paper Language Publishing type Disclose
Robert Alberstein, Yuta Suzuki, Francesco Paesani, and F. Akif Tezcan Robert Alberstein, Yuta Suzuki, Francesco Paesani, and F. Akif Tezcan Robert Alberstein, Yuta Suzuki, Francesco Paesani, and F. Akif Tezcan Engineering the Entropy - Driven Energy Landscape of a Dynamic, Nanoporous Protein Assembly Engineering the Entropy - Driven Energy Landscape of a Dynamic, Nanoporous Protein Assembly Engineering the Entropy - Driven Energy Landscape of a Dynamic, Nanoporous Protein Assembly Nature Chemistry, 10, 732-739 Nature Chemistry, 10, 732-739 Nature Chemistry, 10, 732-739 2018/04 Refereed English Research paper(scientific journal) Disclose to all
Yuta Suzuki, Giovanni Cardone, David Restrepo, Pablo D. Zavattieri, Timothy S. Baker, and F. Akif Tezcan Yuta Suzuki, Giovanni Cardone, David Restrepo, Pablo D. Zavattieri, Timothy S. Baker, and F. Akif Tezcan Yuta Suzuki, Giovanni Cardone, David Restrepo, Pablo D. Zavattieri, Timothy S. Baker, and F. Akif Tezcan Self-Assembly of Coherently Dynamic, Auxetic Two-Dimensional Protein Crystals Self-Assembly of Coherently Dynamic, Auxetic Two-Dimensional Protein Crystals Self-Assembly of Coherently Dynamic, Auxetic Two-Dimensional Protein Crystals Nature, 533, 369-373 Nature, 533, 369-373 Nature, 533, 369-373 2016/05 Refereed English Research paper(scientific journal) Disclose to all
Samuel A. Kotler, Jeffrey R. Brender, Subramanian Vivekanandan, Yuta Suzuki, Kazutoshi Yamamoto, Martine Monette, Janarthanan Krishnamoorthy, Patrick Walsh, Meagan Cauble, Mark M. Banaszak Holl, E. Neil. G. Marsh, and Ayyalusamy Ramamoorthy Samuel A. Kotler, Jeffrey R. Brender, Subramanian Vivekanandan, Yuta Suzuki, Kazutoshi Yamamoto, Martine Monette, Janarthanan Krishnamoorthy, Patrick Walsh, Meagan Cauble, Mark M. Banaszak Holl, E. Neil. G. Marsh, and Ayyalusamy Ramamoorthy Samuel A. Kotler, Jeffrey R. Brender, Subramanian Vivekanandan, Yuta Suzuki, Kazutoshi Yamamoto, Martine Monette, Janarthanan Krishnamoorthy, Patrick Walsh, Meagan Cauble, Mark M. Banaszak Holl, E. Neil. G. Marsh, and Ayyalusamy Ramamoorthy High-resolution NMR characterization of low abundance oligomers of amyloid-β without purification High-resolution NMR characterization of low abundance oligomers of amyloid-β without purification High-resolution NMR characterization of low abundance oligomers of amyloid-β without purification Scientific Reports, 5, 11811 Scientific Reports, 5, 11811 Scientific Reports, 5, 11811 2015/07 Refereed English Research paper(scientific journal) Disclose to all
Hanumantharao Paritala, Yuta Suzuki, and Kate S. Carroll Hanumantharao Paritala, Yuta Suzuki, and Kate S. Carroll Hanumantharao Paritala, Yuta Suzuki, and Kate S. Carroll Design, Synthesis and Evaluation of Fe-S Targeted Adenosine 5′-Phosphosulfate Reductase Inhibitors Design, Synthesis and Evaluation of Fe-S Targeted Adenosine 5′-Phosphosulfate Reductase Inhibitors Design, Synthesis and Evaluation of Fe-S Targeted Adenosine 5′-Phosphosulfate Reductase Inhibitors Nucleosides, Nucleotides and Nucleic Acids, 34, 199-220 Nucleosides, Nucleotides and Nucleic Acids, 34, 199-220 Nucleosides, Nucleotides and Nucleic Acids, 34, 199-220 2015/03 Refereed English Research paper(scientific journal) Disclose to all
E. Neil G. Marsh and Yuta Suzuki E. Neil G. Marsh and Yuta Suzuki E. Neil G. Marsh and Yuta Suzuki Using 19F NMR to Probe Biological Interactions of Proteins and Peptides Using 19F NMR to Probe Biological Interactions of Proteins and Peptides Using 19F NMR to Probe Biological Interactions of Proteins and Peptides ACS Chemical Biology, 9, 1242-1250 ACS Chemical Biology, 9, 1242-1250 ACS Chemical Biology, 9, 1242-1250 2014/04 Refereed English Research paper(scientific journal) Disclose to all
Hanumantharao Paritala, Yuta Suzuki, and Kate S. Carroll Hanumantharao Paritala, Yuta Suzuki, and Kate S. Carroll Hanumantharao Paritala, Yuta Suzuki, and Kate S. Carroll Efficient microwave-assisted solid phase coupling of nucleosides, small library generation, and mild conditions for release of nucleoside derivatives Efficient microwave-assisted solid phase coupling of nucleosides, small library generation, and mild conditions for release of nucleoside derivatives Efficient microwave-assisted solid phase coupling of nucleosides, small library generation, and mild conditions for release of nucleoside derivatives Tetrahedron Letter, 54, 14, 1869-1872 Tetrahedron Letter, 54, 14, 1869-1872 Tetrahedron Letter, 54, 14, 1869-1872 2013/04 Refereed English Research paper(scientific journal) Disclose to all
Yuta Suzuki, Jeffrey R. Brender, Molly T. Soper, Janarthanan Krishnamoorthy, Yunlong Zhou, Brandon T. Ruotolo, Nicholas A. Kotov, Ayyalusamy Ramamoorthy, and E. Neil G. Marsh Yuta Suzuki, Jeffrey R. Brender, Molly T. Soper, Janarthanan Krishnamoorthy, Yunlong Zhou, Brandon T. Ruotolo, Nicholas A. Kotov, Ayyalusamy Ramamoorthy, and E. Neil G. Marsh Yuta Suzuki, Jeffrey R. Brender, Molly T. Soper, Janarthanan Krishnamoorthy, Yunlong Zhou, Brandon T. Ruotolo, Nicholas A. Kotov, Ayyalusamy Ramamoorthy, and E. Neil G. Marsh Resolution of Oligomeric Species during the Aggregation of Aβ1-40 Using 19F NMR Resolution of Oligomeric Species during the Aggregation of Aβ1-40 Using 19F NMR Resolution of Oligomeric Species during the Aggregation of Aβ1-40 Using 19F NMR Biochemistry, 52, 11, 1903-1912 Biochemistry, 52, 11, 1903-1912 Biochemistry, 52, 11, 1903-1912 2013/03 Refereed English Research paper(scientific journal) Disclose to all
Yuta Suzuki Yuta Suzuki Yuta Suzuki Fluorine NMR Studies on the Dynamics and Structure of Biologically Active Peptides. Fluorine NMR Studies on the Dynamics and Structure of Biologically Active Peptides. Fluorine NMR Studies on the Dynamics and Structure of Biologically Active Peptides. University of Michigan, Ann Arbor University of Michigan, Ann Arbor University of Michigan, Ann Arbor 2013 Refereed English Doctoral Thesis Disclose to all
Thangaiah Subramanian, June E. Pais, Suxia Liu, Jerry M. Troutman, Yuta Suzuki, Karunai L. Subramanian, Carol A. Fierke, Douglas A. Andres, and H. Peter Spielmann Thangaiah Subramanian, June E. Pais, Suxia Liu, Jerry M. Troutman, Yuta Suzuki, Karunai L. Subramanian, Carol A. Fierke, Douglas A. Andres, and H. Peter Spielmann Thangaiah Subramanian, June E. Pais, Suxia Liu, Jerry M. Troutman, Yuta Suzuki, Karunai L. Subramanian, Carol A. Fierke, Douglas A. Andres, and H. Peter Spielmann Farnesyl Diphosphate Analogues with Aryl Moieties are Efficient Alternate Substrates for Protein Farnesyltransferase Farnesyl Diphosphate Analogues with Aryl Moieties are Efficient Alternate Substrates for Protein Farnesyltransferase Farnesyl Diphosphate Analogues with Aryl Moieties are Efficient Alternate Substrates for Protein Farnesyltransferase Biochemistry, 51, 41, 8307-8319 Biochemistry, 51, 41, 8307-8319 Biochemistry, 51, 41, 8307-8319 2012/10 Refereed English Research paper(scientific journal) Disclose to all
Yuta Suzuki, Jeffrey R. Brender, Kevin Hartman, Ayyalusamy Ramamoorthy, and E. Neil G. Marsh Yuta Suzuki, Jeffrey R. Brender, Kevin Hartman, Ayyalusamy Ramamoorthy, and E. Neil G. Marsh Yuta Suzuki, Jeffrey R. Brender, Kevin Hartman, Ayyalusamy Ramamoorthy, and E. Neil G. Marsh Alternative Pathways of Human Islet Amyloid Polypeptide Aggregation Distinguished by 19F NMR Detected Kinetics of Monomer Consumption. Alternative Pathways of Human Islet Amyloid Polypeptide Aggregation Distinguished by 19F NMR Detected Kinetics of Monomer Consumption. Alternative Pathways of Human Islet Amyloid Polypeptide Aggregation Distinguished by 19F NMR Detected Kinetics of Monomer Consumption. Biochemistry, 51, 41, 8154-8162 Biochemistry, 51, 41, 8154-8162 Biochemistry, 51, 41, 8154-8162 2012/09 Refereed English Research paper(scientific journal) Disclose to all
Richard P. Cheng, Yi-Jen Weng, Wei-Ren Wang, Marc J. Koyack, Yuta Suzuki, Cheng-Hsun Wu, Po-An Yang, Hao-Chun Hsu, Hsiou-Ting Kuo, Prashant Girinath, Chun-Jen Fang Richard P. Cheng, Yi-Jen Weng, Wei-Ren Wang, Marc J. Koyack, Yuta Suzuki, Cheng-Hsun Wu, Po-An Yang, Hao-Chun Hsu, Hsiou-Ting Kuo, Prashant Girinath, Chun-Jen Fang Richard P. Cheng, Yi-Jen Weng, Wei-Ren Wang, Marc J. Koyack, Yuta Suzuki, Cheng-Hsun Wu, Po-An Yang, Hao-Chun Hsu, Hsiou-Ting Kuo, Prashant Girinath, Chun-Jen Fang Helix Formation and Capping Energetics of Arginine Analogs with Varying Side Chain Length Helix Formation and Capping Energetics of Arginine Analogs with Varying Side Chain Length Helix Formation and Capping Energetics of Arginine Analogs with Varying Side Chain Length Amino Acids, 43, 1, 195-206 Amino Acids, 43, 1, 195-206 Amino Acids, 43, 1, 195-206 2011/09 Refereed English Research paper(scientific journal) Disclose to all
Yuta Suzuki, Benjamin C. Buer, Hashim M. Al-Hashimi, and E. Neil G. Marsh Yuta Suzuki, Benjamin C. Buer, Hashim M. Al-Hashimi, and E. Neil G. Marsh Yuta Suzuki, Benjamin C. Buer, Hashim M. Al-Hashimi, and E. Neil G. Marsh Using Fluorine NMR to Probe Changes in Structure and Dynamics of Membrane-Active Peptides Interacting with the Lipid Bilayer Using Fluorine NMR to Probe Changes in Structure and Dynamics of Membrane-Active Peptides Interacting with the Lipid Bilayer Using Fluorine NMR to Probe Changes in Structure and Dynamics of Membrane-Active Peptides Interacting with the Lipid Bilayer Biochemistry, 50, 27, 5979-5987 Biochemistry, 50, 27, 5979-5987 Biochemistry, 50, 27, 5979-5987 2011/07 Refereed English Research paper(scientific journal) Disclose to all
Richard P. Cheng, Prashant Girinath, Yuta Suzuki, Hsiou-Ting Kuo, Hao-Chun Hsu, Wei-Ren Wang, Po-An Yang, Donald Gullickson, Cheng-Hsun Wu, Marc J. Koyack, Hsien-Po Chiu, Yi-Jen Weng, Pier Hart, Bashkim Kokona, Robert Fairman, Tzu-En Lin, and Olivia Barrett Richard P. Cheng, Prashant Girinath, Yuta Suzuki, Hsiou-Ting Kuo, Hao-Chun Hsu, Wei-Ren Wang, Po-An Yang, Donald Gullickson, Cheng-Hsun Wu, Marc J. Koyack, Hsien-Po Chiu, Yi-Jen Weng, Pier Hart, Bashkim Kokona, Robert Fairman, Tzu-En Lin, and Olivia Barrett Richard P. Cheng, Prashant Girinath, Yuta Suzuki, Hsiou-Ting Kuo, Hao-Chun Hsu, Wei-Ren Wang, Po-An Yang, Donald Gullickson, Cheng-Hsun Wu, Marc J. Koyack, Hsien-Po Chiu, Yi-Jen Weng, Pier Hart, Bashkim Kokona, Robert Fairman, Tzu-En Lin, and Olivia Barrett Positional Effects on Helical Ala-Based Peptides Positional Effects on Helical Ala-Based Peptides Positional Effects on Helical Ala-Based Peptides Biochemistry, 49, 43, 9372-9384 Biochemistry, 49, 43, 9372-9384 Biochemistry, 49, 43, 9372-9384 2010/10 Refereed English Research paper(scientific journal) Disclose to all
Hsien-Po Chiu, Yuta Suzuki, Donald Gullickson, Raheel Ahmad, Bashkim Kokona, Robert Fairman, and Richard P. Cheng Hsien-Po Chiu, Yuta Suzuki, Donald Gullickson, Raheel Ahmad, Bashkim Kokona, Robert Fairman, and Richard P. Cheng Hsien-Po Chiu, Yuta Suzuki, Donald Gullickson, Raheel Ahmad, Bashkim Kokona, Robert Fairman, and Richard P. Cheng Helix Propensity of Highly Fluorinated Amino Acids Helix Propensity of Highly Fluorinated Amino Acids Helix Propensity of Highly Fluorinated Amino Acids Journal of the American Chemical Society, 128, 49, 15556-15557 Journal of the American Chemical Society, 128, 49, 15556-15557 Journal of the American Chemical Society, 128, 49, 15556-15557 2006/11 Refereed English Research paper(scientific journal) Disclose to all

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Author Author(Japanese) Author(English) Title Title(Japanese) Title(English) Bibliography Bibliography(Japanese) Bibliography(English) Publication date Refereed paper Language Publishing type Disclose
鈴木 雄太 鈴木 雄太 SUNY/ミシガン/UCSD大学留学体験記 ~From Art To Chemistry~” SUNY/ミシガン/UCSD大学留学体験記 ~From Art To Chemistry~” 生命化学研究レター, 53, 26-33 生命化学研究レター, 53, 26-33 , 53, 26-33 2017/02 Japanese Prompt report, short report, and research note, etc.(scientific journal) Disclose to all
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