小段 篤史

Last Update: 2016/07/29 17:00:11

Print

Name(Kanji/Kana/Abecedarium Latinum)
小段 篤史/コダン アツシ/Atsushi Kodan
Primary department(Org1/Org2/Org3/Job title)
農学研究科/応用生命科学専攻応用生化学講座/特定研究員
Contact address
Type Address(Japanese) Address(English)
Office
Phone
Type Number
Office
Academic degree
Field(Japanese) Field(English) University(Japanese) University(English) Method
修士(農学) 京都大学
博士(農学) 京都大学
Research Topics
(Japanese)
ABCタンパク質の立体構造研究
(English)
Structural analysis of ABC proteins
Overview of your research
(English)
ABC proteins are involved in host defense mechanisms, glucose homeostasis, and lipid homeostasis. Defects in their functions cause various diseases, suggesting that they play very important roles for human wellness. Although their predicted secondary structures are very much alike and share well-conserved nucleotide binding domains, they have divergent functions and can be classified as transporters, channels, and regulators. Furthermore, some ABC proteins, such as ABCA1 and ABCG1, are proposed to be involved in the re-organization of raft-like membrane meso-domain. However, the mechanisms of their functions are still not clear. Thus, determination of three-dimensional structure at high resolution is important to elucidate their functions. The findings would allow us to design integrated functional architectures of physiologically important ABC proteins.
Fields of research (key words)
Key words(Japanese) Key words(English)
ABCタンパク質 ABC proteins
膜タンパク質 membrane proteins
Fields of research (kaken code)
Kaken code
Applied pharmacology
Physical pharmaceutical science
Applied Biochemistry
Published Papers > Published Papers
(文系研究者の一般的な論文集への寄稿や単行本の分担執筆などは「著書等」を参照してください)
Authors Title Bibliography Date Peer-Review Language
A. Kodan; T. Yamaguchi; T. Nakatsu; K. Sakiyama; C.J. Hipolito; A. Fujioka; R. Hirokane; K. Ikeguchi; B. Watanabe; J. Hiratake; Y. Kimura; H. Suga; K. Ueda; H. Kato Structural basis for gating mechanisms of a eukaryotic P-glycoprotein homolog Proceedings of the National Academy of Sciences of the United States of America,111,11,4049-4054 2014 Refereed English
K. Terakado; A. Kodan; H. Nakano; Y. Kimura; K. Ueda; T. Nakatsu; H. Kato Deleting two C-terminal α-helices is effective to crystallize the bacterial ABC transporter Escherichia coli MsbA complexed with AMP-PNP Acta Crystallographica Section D: Biological Crystallography,66,Pt 3,319-323 2010/03 Refereed Japanese
T. Sato; A. Kodan; Y. Kimura; K. Ueda; T. Nakatsu; H. Kato Functional role of the linker region in purified human P-glycoprotein FEBS Journal,276,13,3504-3516 2009/07 Refereed English
A. Kodan; H. Shibata; T. Matsumoto; K. Terakado; K. Sakiyama; M. Matsuo; K. Ueda; H. Kato Improved expression and purification of human multidrug resistance protein MDR1 from baculovirus-infected insect cells Protein Expression and Purification,66,1,7-14 2009/07 Refereed English
Y. Kimura; A. Kodan; M. Matsuo; K. Ueda Cholesterol fill-in model: Mechanism for substrate recognition by ABC proteins Journal of Bioenergetics and Biomembranes,39,5-6,447-452 2007/12 Refereed English
A. Kodan; H. Kuroda; F. Sakai A stilbene synthase from Japanese red pine (Pinus densiflora): Implications for phytoalexin accumulation and down-regulation of flavonoid biosynthesis Proceedings of the National Academy of Sciences of the United States of America,99,5,3335-3339 2002/03 Refereed English
A. Kodan; H. Kuroda; F. Sakai Simultaneous expression of stilbene synthase genes in Japanese red pine (Pinus densiflora) seedlings Journal of Wood Science,47,1,58-62 2001 Refereed English
Conference Presentation > Conference Presentation
(文系研究者の一般的な学会報告の業績は「講演等」を参照してください)
Authors Title Bibliography Date Peer-Review Language
小段篤史、木村泰久、加藤博章、植田和光 ABC(ATP-binding cassette)タンパク質の構造解析が拓く創薬の未来 未来材料,6,10,30-36 2006/10 Refereed Japanese
Lectures > Invited Lectures
(文系研究者の一般的な学会報告はこの項に収録されております)
Title Conference name Organization name Date Language
High-resolution crystal structure of an ABC multidrug exporter from Cyanidioschyzon merolae, a thermophilic unicellular eukaryote [Invited] ABC2014, the 5th FEBS Special Meeting “ATP-Binding Cassette Proteins: From Multidrug Resistance to Genetic Disease” 2014/03/08 English
Lectures > Public Talks
(文系研究者の一般的な学会報告はこの項に収録されております)
Title Conference name Organization name Date Language
X-ray crystallographic analysis of an exporter-type ABC transporter. 4th FEBS Special Meeting on ABC Proteins - ABC2012 2012/03/03 English
X-ray crystallographic analysis of an exporter-type ABC transporter Kakenhi Kiban (S)/iCeMS Joint International Symposium “ABC2011 in Kyoto -ABC Proteins/Membrane Meso-domains/ES-iPS cells” 2011/11/11 English
Publications > Books
Authors Title Publisher Date Language
小段篤史、木村泰久、加藤博章、植田和光 ABC (ATP-binding cassette) タンパク質の構造解析が拓く創薬の未来 エヌ・ティー・エス 2006 Japanese
加藤博章、小段篤史、柴田洋之 ABC蛋白質の立体構造研究—現状と課題 「ABC蛋白質」(編集:植田和光) 学会出版センター p245-274 2005 Japanese
Newspaper articles
Title Media name Column name Date
「京大と東大、がん化学療法の阻害たんぱく質の類似分子構造を解明」 日刊工業新聞 19面 2014/03/04
Article Recommendations F1000Prime http://f1000.com/prime/718297947 2014/04/04
京大グループ、抗がん剤働きを阻害、原因タンパク質を解明、薬剤開発に期待 京都新聞 27面 2014/03/04
薬効かない再発がん、仕組み解明 読売新聞 17面 2014/03/31
External funds, competitive funds and Grants-in-Aid for Scientific Research(kaken)
Type Position Title(Japanese) Title(English) Period
若手研究(B) Representative ABC輸送体のX線結晶構造解析 2010/04/01-2012/03/31
若手研究(A) Representative ABC輸送体の分子機構の解明     2012/04/01-2013/03/31
若手研究(A) Representative ABC輸送体の分子機構の解明     2012/04/01-2013/03/31
若手研究(A) Representative ABC輸送体の分子機構の解明     2013/04/01-2014/03/31
若手研究(A) Representative ABC輸送体の分子機構の解明     2013/04/01-2014/03/31
若手研究(A) Representative ABC輸送体の分子機構の解明     2014/04/01-2015/03/31
若手研究(A) Representative ABC輸送体の分子機構の解明     2014/04/01-2015/03/31
Non-external, competitive funds or grants other than grants-in-aid for Scientific research (kaken)
System Main person Title(Japanese) Title(English) Period
京都大学コアステージバックアップ研究費 小段 篤史 ABC輸送体による薬物輸送の構造基盤 Structural basis for drug transport of ABC transporters 2015/04/01-2016/03/31
Teaching subject(s)
Name(Japanese) Name(English) Term Department Period
細胞生化学専攻実験1 Experimental Course of Cellular Biochemistry1 通年 農学研究科 2015/04-2016/03
細胞生化学専攻実験 Experimental Course of Cellular Biochemistry 通年 農学研究科 2015/04-2016/03
細胞生化学専攻演習1 Cellular Biochemistry Seminar1 通年 農学研究科 2015/04-2016/03
細胞生化学専攻演習 Cellular Biochemistry Seminar 通年 農学研究科 2015/04-2016/03
細胞生化学専攻実験1 Experimental Course of Cellular Biochemistry1 通年 農学研究科 2016/04-2017/03
細胞生化学専攻実験2 Experimental Course of Cellular Biochemistry2 通年 農学研究科 2016/04-2017/03
細胞生化学専攻実験 Experimental Course of Cellular Biochemistry 通年 農学研究科 2016/04-2017/03
細胞生化学専攻演習1 Cellular Biochemistry Seminar1 通年 農学研究科 2016/04-2017/03
細胞生化学専攻演習2 Cellular Biochemistry Seminar2 通年 農学研究科 2016/04-2017/03
細胞生化学専攻演習 Cellular Biochemistry Seminar 通年 農学研究科 2016/04-2017/03