松﨑 朋子

Last Update: 2020/07/29 13:58:32

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Name(Kanji/Kana/Abecedarium Latinum)
松﨑 朋子/マツザキ トモコ/Matsuzaki, Tomoko
Primary Affiliation(Org1/Job title)
Graduate Schools Medicine/Assistant Professor
Faculty
Org1 Job title
医学部
Academic Organizations You are Affiliated to in Japan
Organization name(Japanese) Organization name(English)
日本生化学会 The Japanese Biochemical Society
日本癌学会 Japanese Cancer Association
日本分子生物学会 The Molecular Biology Society of Japan
Academic Degree
Field(Japanese) Field(English) University(Japanese) University(English) Method
博士(医学) Doctor of Philosophy 東京医科歯科大学 Tokyo Medical and Dental University
Personal Profile
(Japanese)
細胞外で働くたんぱく質がいかに生体の機能を調節しているかを細胞外マトリックスの変化を通して調べています。様々な細胞外マトリックス制御因子が生体そのものの運命を左右している事を良く理解することによって、生命の謎を解き明かすと共に、様々な疾患の治療に役立てればと考えます。
(English)
I stady on regulators of extracelluler matrix remodeling. I am interested in how extracellular stimuli can affect the cell fate and how the cells control their enviroment.
Language of Instruction
Language(japanese) Language(english) Code
日本語 Japanese jpn
英語 English eng
researchmap URL
https://researchmap.jp/7000008421
Research Topics
(Japanese)
細胞外マトリックス(ECM)制御因子の個体発生、恒常性維持、腫瘍形成における役割解明
(English)
Studies on the roles of extracellular-matrix-regulators in animal development, homeostasis, and tumor suppression.
Overview of the research
(Japanese)
多くのがんで発現が抑制されているがん抑制遺伝子RECKは、マトリックスメタロプロテアーゼ(MMPs)抑制、NotchリガンドのADAM10による放出の制御、Wnt7シグナルの増強などの働きを持つことが既に知られている。我々は、新たに、RECKがマウス胎児脳血管形成においてWnt7シグナルのレセプター側(GPR124-FZD-LRP)だけでなくリガンド側(Wnt7)においてもシグナル伝達にとって必須の役割を担う事を見出した。成体マウスを用いた研究では、RECKが下垂体の成長ホルモン(GH)産生細胞で発現されており、成長ホルモン放出ホルモン受容体(GHRHR)やグレリン受容体(GHSR)の安定化に寄与していること、また、肝臓においても成長ホルモン受容体(GHR)の安定化に寄与している事を発見した。また、RECKはマルファン症候群で変異が見られるフィブリリン1(FBN1)と生体内で共発現しており、膜結合型マトリックスメタロプロテアーゼ(MT1-MMP)、メタロプロテアーゼ(ADAMTS10)と共に、FBN1線維形成に重要な役割を演ずる事を見出した。さらに、皮膚線維芽細胞ではRECKがproMT1-MMPを活性化するのに対し、精製したRECKは活性化型MT1-MMPの活性を抑制するという興味深い現象を見出した。これらの知見は、RECKの生理機能やフィブリリン細毛線維形成の分子機構に新たな光を当て、がん、成長障害、結合組織異常などの病態解明に資するものと考えている。
(English)
The tumor suppressor protein RECK has been implicated in the regulation of matrix metalloproteinases (MMPs), Notch-signaling, and WNT7-signaling. We recently found that RECK plays roles essential for vascular development in mouse central nervous system (CNS) not only on the receptor (GPR124-FZD-LRP) side but also on the ligand (Wnt7a/b) side of WNT7-signaling. In adult mouse, RECK is expressed abundantly in growth hormone (GH)-producing cells in anterior pituitary gland. We found that RECK contributes to the stabilization of several receptors involved in the GH-IGF1 axis (i.e., GHRHR, GHSR, GHR). We also found that RECK and fibrillin-1 are coexpressed in many human tissues. Fibrillin-1 mutations are found in Marfan syndrome. Our data suggest that three proteins, RECK, ADAMTS10 (secreted metalloprotease), and MT1-MMP (secreted membrane-bound matrix-metalloprotease) cooperate to support the formation of robust fibrillin-1 fibers. Interestingly, RECK is capable of activating proMT1-MMP in mouse dermal fibroblasts while it inhibits mature MT1-MMP in vitro. These findings shed some new lights on the physiological functions of RECK, the molecular mechanisms of fibrillin fiber formation, and the molecular bases of diseases such as cancer, growth defects, and connective tissue disorders.
Fields of research (key words)
Key words(Japanese) Key words(English)
分子腫瘍学 molecular oncology
細胞外マトリックス extracellular-matrix
がん抑制遺伝子 tumor suppressor gene
Published Papers
Author Author(Japanese) Author(English) Title Title(Japanese) Title(English) Bibliography Bibliography(Japanese) Bibliography(English) Publication date Refereed paper Language Publishing type Disclose
TomokoMatsuzaki, HitoshiKitayama, AkiraOmura, EmiNishimoto, DavidB.Alexander and MakotoNoda 松﨑 朋子、北山仁、大村彰、西幹栄美、ディビッド アレクサンダー、野田亮 TomokoMatsuzaki, HitoshiKitayama, AkiraOmura, EmiNishimoto, DavidB.Alexander and MakotoNoda The RECK tumor suppressor protein binds and stabilizes ADAMTS10 The RECK tumor suppressor protein binds and stabilizes ADAMTS10 The RECK tumor suppressor protein binds and stabilizes ADAMTS10 Biology open, 7, 10 Biology open, 7, 10 Biology open, 7, 10 2018/10 Refereed English Research paper(scientific journal) Disclose to all
Matsuzaki T, Wang H, Imamura Y, Kondo S, Ogawa S, Noda M. Matsuzaki T, Wang H, Imamura Y, Kondo S, Ogawa S, Noda M. Generation and characterization of a mouse line carrying Reck-CreERT2 knock-in allele. Generation and characterization of a mouse line carrying Reck-CreERT2 knock-in allele. Generation and characterization of a mouse line carrying Reck-CreERT2 knock-in allele. Genesis, 56, 4, e23099 Genesis, 56, 4, e23099 Genesis, 56, 4, e23099 2018/04 Refereed English Research paper(scientific journal) Disclose to all
Almeida GM, Yamamoto M, Morioka Y, Ogawa S, Matsuzaki T, Noda M. Almeida GM, Yamamoto M, Morioka Y, Ogawa S, Matsuzaki T, Noda M. Critical roles for murine Reck in the regulation of vascular patterning and stabilization. Critical roles for murine Reck in the regulation of vascular patterning and stabilization. Critical roles for murine Reck in the regulation of vascular patterning and stabilization. Sci Rep, 5, 17860 Sci Rep, 5, 17860 Sci Rep, 5, 17860 2015 Refereed English Research paper(scientific journal) Disclose to all
Yamamoto M, Matsuzaki T, Takahashi R, Adachi E, Maeda Y, Yamaguchi S, Kitayama H, Echizenya M, Morioka Y, Alexander DB, Yagi T, Itohara S, Nakamura T, Akiyama H, Noda M. Yamamoto M, Matsuzaki T, Takahashi R, Adachi E, Maeda Y, Yamaguchi S, Kitayama H, Echizenya M, Morioka Y, Alexander DB, Yagi T, Itohara S, Nakamura T, Akiyama H, Noda M. The transformation suppressor gene Reck is required for postaxial patterning in mouse forelimbs. The transformation suppressor gene Reck is required for postaxial patterning in mouse forelimbs. The transformation suppressor gene Reck is required for postaxial patterning in mouse forelimbs. Biol Open, 1, 458-466 Biol Open, 1, 458-466 Biol Open, 1, 458-466 2012 Refereed English Research paper(scientific journal) Disclose to all
E.P. Chandana; Y. Maeda; A. Ueda; H. Kiyonari; N. Oshima; M. Yamamoto; S. Kondo; J. Oh; R. Takahashi; Y. Yoshida; S. Kawashima; D.B. Alexander; H. Kitayama; C. Takahashi; Y. Tabata; T. Matsuzaki; M. Noda E.P. Chandana; Y. Maeda; A. Ueda; H. Kiyonari; N. Oshima; M. Yamamoto; S. Kondo; J. Oh; R. Takahashi; Y. Yoshida; S. Kawashima; D.B. Alexander; H. Kitayama; C. Takahashi; Y. Tabata; T. Matsuzaki; M. Noda E.P. Chandana; Y. Maeda; A. Ueda; H. Kiyonari; N. Oshima; M. Yamamoto; S. Kondo; J. Oh; R. Takahashi; Y. Yoshida; S. Kawashima; D.B. Alexander; H. Kitayama; C. Takahashi; Y. Tabata; T. Matsuzaki; M. Noda Involvement of the Reck tumor suppressor protein in maternal and embryonic vascular remodeling in mice Involvement of the Reck tumor suppressor protein in maternal and embryonic vascular remodeling in mice Involvement of the Reck tumor suppressor protein in maternal and embryonic vascular remodeling in mice BMC Developmental Biology, 10 BMC Developmental Biology, 10 BMC Developmental Biology, 10 2010/08/06 Refereed English Disclose to all
M. Noda; C. Takahashi; T. Matsuzaki; H. Kitayama M. Noda; C. Takahashi; T. Matsuzaki; H. Kitayama M. Noda; C. Takahashi; T. Matsuzaki; H. Kitayama What we learn from transformation suppressor genes: Lessons from RECK What we learn from transformation suppressor genes: Lessons from RECK What we learn from transformation suppressor genes: Lessons from RECK Future Oncology, 6, 7, 1105-1116 Future Oncology, 6, 7, 1105-1116 Future Oncology, 6, 7, 1105-1116 2010/07 Refereed English Disclose to all
F. Loayza-Puch; Y. Yoshida; T. Matsuzaki; C. Takahashi; H. Kitayama; M. Noda F. Loayza-Puch; Y. Yoshida; T. Matsuzaki; C. Takahashi; H. Kitayama; M. Noda F. Loayza-Puch; Y. Yoshida; T. Matsuzaki; C. Takahashi; H. Kitayama; M. Noda Hypoxia and RAS-signaling pathways converge on, and cooperatively downregulate, the RECK tumor-suppressor protein through microRNAs Hypoxia and RAS-signaling pathways converge on, and cooperatively downregulate, the RECK tumor-suppressor protein through microRNAs Hypoxia and RAS-signaling pathways converge on, and cooperatively downregulate, the RECK tumor-suppressor protein through microRNAs Oncogene, 29, 18, 2638-2648 Oncogene, 29, 18, 2638-2648 Oncogene, 29, 18, 2638-2648 2010/05/06 Refereed English Disclose to all
5. Loayza-Puch, F., Yoshida, Y., Matsuzaki, T., Takahashi, C., Kitayama, H., *Noda,M.: 5. Loayza-Puch, F., Yoshida, Y., Matsuzaki, T., Takahashi, C., Kitayama, H., *Noda,M.: 5. Loayza-Puch, F., Yoshida, Y., Matsuzaki, T., Takahashi, C., Kitayama, H., *Noda,M.: Hypoxia and RAS signaling pathways converge on, and cooperatively down-regulate, the RECK tumor suppressor protein via microRNAs. Oncogene 2010 2010 May 6;29(18):2638-48. Epub 2010 Feb 15. Hypoxia and RAS signaling pathways converge on, and cooperatively down-regulate, the RECK tumor suppressor protein via microRNAs. Oncogene 2010 2010 May 6;29(18):2638-48. Epub 2010 Feb 15. Hypoxia and RAS signaling pathways converge on, and cooperatively down-regulate, the RECK tumor suppressor protein via microRNAs. Oncogene 2010 2010 May 6;29(18):2638-48. Epub 2010 Feb 15. 2010 Refereed English Disclose to all
M. Hatta; T. Matsuzaki; Y. Morioka; Y. Yoshida; M. Noda M. Hatta; T. Matsuzaki; Y. Morioka; Y. Yoshida; M. Noda M. Hatta; T. Matsuzaki; Y. Morioka; Y. Yoshida; M. Noda Density- and serum-dependent regulation of the Reck tumor suppressor in mouse embryo fibroblasts Density- and serum-dependent regulation of the Reck tumor suppressor in mouse embryo fibroblasts Density- and serum-dependent regulation of the Reck tumor suppressor in mouse embryo fibroblasts Cellular Signalling, 21, 12, 1885-1893 Cellular Signalling, 21, 12, 1885-1893 Cellular Signalling, 21, 12, 1885-1893 2009/12 Refereed English Disclose to all
Y. Morioka; J. Monypenny; T. Matsuzaki; S. Shi; D.B. Alexander; H. Kitayama; M. Noda Y. Morioka; J. Monypenny; T. Matsuzaki; S. Shi; D.B. Alexander; H. Kitayama; M. Noda Y. Morioka; J. Monypenny; T. Matsuzaki; S. Shi; D.B. Alexander; H. Kitayama; M. Noda The membrane-anchored metalloproteinase regulator RECK stabilizes focal adhesions and anterior-posterior polarity in fibroblasts The membrane-anchored metalloproteinase regulator RECK stabilizes focal adhesions and anterior-posterior polarity in fibroblasts The membrane-anchored metalloproteinase regulator RECK stabilizes focal adhesions and anterior-posterior polarity in fibroblasts Oncogene, 28, 11, 1454-1464 Oncogene, 28, 11, 1454-1464 Oncogene, 28, 11, 1454-1464 2009/03 Refereed English Disclose to all
A. Omura; T. Matsuzaki; K. Mio; T. Ogura; M. Yamamoto; A. Fujita; K. Okawa; H. Kitayama; C. Takahashi; C. Sato; M. Noda A. Omura; T. Matsuzaki; K. Mio; T. Ogura; M. Yamamoto; A. Fujita; K. Okawa; H. Kitayama; C. Takahashi; C. Sato; M. Noda A. Omura; T. Matsuzaki; K. Mio; T. Ogura; M. Yamamoto; A. Fujita; K. Okawa; H. Kitayama; C. Takahashi; C. Sato; M. Noda RECK forms cowbell-shaped dimers and inhibits matrix metalloproteinase-catalyzed cleavage of fibronectin RECK forms cowbell-shaped dimers and inhibits matrix metalloproteinase-catalyzed cleavage of fibronectin RECK forms cowbell-shaped dimers and inhibits matrix metalloproteinase-catalyzed cleavage of fibronectin Journal of Biological Chemistry, 284, 6, 3461-3469 Journal of Biological Chemistry, 284, 6, 3461-3469 Journal of Biological Chemistry, 284, 6, 3461-3469 2009/02/06 Refereed English Disclose to all
Y. Ohne; T. Takahara; R. Hatakeyama; T. Matsuzaki; M. Noda; N. Mizushima; T. Maeda Y. Ohne; T. Takahara; R. Hatakeyama; T. Matsuzaki; M. Noda; N. Mizushima; T. Maeda Y. Ohne; T. Takahara; R. Hatakeyama; T. Matsuzaki; M. Noda; N. Mizushima; T. Maeda Isolation of hyperactive mutants of mammalian target of rapamycin Isolation of hyperactive mutants of mammalian target of rapamycin Isolation of hyperactive mutants of mammalian target of rapamycin Journal of Biological Chemistry, 283, 46, 31861-31870 Journal of Biological Chemistry, 283, 46, 31861-31870 Journal of Biological Chemistry, 283, 46, 31861-31870 2008/11/14 Refereed English Disclose to all
T. Matsuzaki; K.-I. Aisaki; Y. Yamamura; M. Noda; Y. Ikawa T. Matsuzaki; K.-I. Aisaki; Y. Yamamura; M. Noda; Y. Ikawa T. Matsuzaki; K.-I. Aisaki; Y. Yamamura; M. Noda; Y. Ikawa Induction of erythroid differentiation by inhibition of Ras/ERK pathway in a Friend murine leukemia cell line Induction of erythroid differentiation by inhibition of Ras/ERK pathway in a Friend murine leukemia cell line Induction of erythroid differentiation by inhibition of Ras/ERK pathway in a Friend murine leukemia cell line Oncogene, 19, 12, 1500-1508 Oncogene, 19, 12, 1500-1508 Oncogene, 19, 12, 1500-1508 2000 Refereed English Disclose to all
Y. Yamamura; H. Senda; Y. Kageyama; T. Matsuzaki; M. Noda; Y. Ikawa Y. Yamamura; H. Senda; Y. Kageyama; T. Matsuzaki; M. Noda; Y. Ikawa Y. Yamamura; H. Senda; Y. Kageyama; T. Matsuzaki; M. Noda; Y. Ikawa Erythropoietin and Friend virus gp55 activate different JAK/STAT pathways through the erythropoietin receptor in erythroid cells Erythropoietin and Friend virus gp55 activate different JAK/STAT pathways through the erythropoietin receptor in erythroid cells Erythropoietin and Friend virus gp55 activate different JAK/STAT pathways through the erythropoietin receptor in erythroid cells Molecular and Cellular Biology, 18, 3, 1172-1180 Molecular and Cellular Biology, 18, 3, 1172-1180 Molecular and Cellular Biology, 18, 3, 1172-1180 1998 Refereed English Disclose to all
C. Takahashi; N. Akiyama; T. Matsuzaki; S. Takai; H. Kitayama; M. Noda C. Takahashi; N. Akiyama; T. Matsuzaki; S. Takai; H. Kitayama; M. Noda C. Takahashi; N. Akiyama; T. Matsuzaki; S. Takai; H. Kitayama; M. Noda Characterization of a human MSX-2 cDNA and its fragment isolated as a transformation suppressor gene against v-Ki-ras oncogene Characterization of a human MSX-2 cDNA and its fragment isolated as a transformation suppressor gene against v-Ki-ras oncogene Characterization of a human MSX-2 cDNA and its fragment isolated as a transformation suppressor gene against v-Ki-ras oncogene Oncogene, 12, 10, 2137-2146 Oncogene, 12, 10, 2137-2146 Oncogene, 12, 10, 2137-2146 1996 Refereed English Disclose to all
S. Murata; T. Matsuzaki; S. Takai; H. Yaoita; M. Noda S. Murata; T. Matsuzaki; S. Takai; H. Yaoita; M. Noda S. Murata; T. Matsuzaki; S. Takai; H. Yaoita; M. Noda A new retroviral vector for detecting mutations and chromosomal instability in mammalian cells A new retroviral vector for detecting mutations and chromosomal instability in mammalian cells A new retroviral vector for detecting mutations and chromosomal instability in mammalian cells Mutation Research/Environmental Mutagenesis and Related Subjects, 334, 3, 375-383 Mutation Research/Environmental Mutagenesis and Related Subjects, 334, 3, 375-383 Mutation Research/Environmental Mutagenesis and Related Subjects, 334, 3, 375-383 1995 Refereed English Disclose to all
S. Kumar; T. Matsuzaki; Y. Yoshida; M. Noda S. Kumar; T. Matsuzaki; Y. Yoshida; M. Noda S. Kumar; T. Matsuzaki; Y. Yoshida; M. Noda Molecular cloning and biological activity of a novel developmentally regulated gene encoding a protein with β-transducin-like structure Molecular cloning and biological activity of a novel developmentally regulated gene encoding a protein with β-transducin-like structure Molecular cloning and biological activity of a novel developmentally regulated gene encoding a protein with β-transducin-like structure Journal of Biological Chemistry, 269, 15, 11318-11326 Journal of Biological Chemistry, 269, 15, 11318-11326 Journal of Biological Chemistry, 269, 15, 11318-11326 1994 Refereed English Disclose to all
H. Kitayama; T. Matsuzaki; Y. Sugimoto; Y. Ikawa; M. Noda H. Kitayama; T. Matsuzaki; Y. Sugimoto; Y. Ikawa; M. Noda H. Kitayama; T. Matsuzaki; Y. Sugimoto; Y. Ikawa; M. Noda Genetic analysis of the K-rev-1 transformation-suppressor gene Genetic analysis of the K-rev-1 transformation-suppressor gene Genetic analysis of the K-rev-1 transformation-suppressor gene Environmental Health Perspectives, 93, 73-77 Environmental Health Perspectives, 93, 73-77 Environmental Health Perspectives, 93, 73-77 1991 Refereed English Disclose to all
H. Kitayama; T. Matsuzaki; Y. Ikawa; M. Noda H. Kitayama; T. Matsuzaki; Y. Ikawa; M. Noda H. Kitayama; T. Matsuzaki; Y. Ikawa; M. Noda A domain responsible for the transformation suppressor activity in Krev-1 protein A domain responsible for the transformation suppressor activity in Krev-1 protein A domain responsible for the transformation suppressor activity in Krev-1 protein Japanese Journal of Cancer Research, 81, 5, 445-448 Japanese Journal of Cancer Research, 81, 5, 445-448 Japanese Journal of Cancer Research, 81, 5, 445-448 1990/05 Refereed English Disclose to all
H. Kitayama; Y. Sugimoto; T. Matsuzaki; Y. Ikawa; M. Noda H. Kitayama; Y. Sugimoto; T. Matsuzaki; Y. Ikawa; M. Noda H. Kitayama; Y. Sugimoto; T. Matsuzaki; Y. Ikawa; M. Noda A ras-related gene with transformation suppressor activity A ras-related gene with transformation suppressor activity A ras-related gene with transformation suppressor activity Cell, 56, 1, 77-84 Cell, 56, 1, 77-84 Cell, 56, 1, 77-84 1989/01/13 Refereed English Disclose to all
M. Noda; H. Kitayama; S. Kanazawa; S. Murata; T. Matsuzaki; Y. Ikawa M. Noda; H. Kitayama; S. Kanazawa; S. Murata; T. Matsuzaki; Y. Ikawa M. Noda; H. Kitayama; S. Kanazawa; S. Murata; T. Matsuzaki; Y. Ikawa Transformation suppressor genes. Transformation suppressor genes. Transformation suppressor genes. Princess Takamatsu symposia, 20, 233-239 Princess Takamatsu symposia, 20, 233-239 Princess Takamatsu symposia, 20, 233-239 1989 Refereed English Disclose to all

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Misc
Author Author(Japanese) Author(English) Title Title(Japanese) Title(English) Bibliography Bibliography(Japanese) Bibliography(English) Publication date Refereed paper Language Publishing type Disclose
H. Kitayama; T. Matsuzaki; Y. Ikawa; M. Noda H. Kitayama; T. Matsuzaki; Y. Ikawa; M. Noda H. Kitayama; T. Matsuzaki; Y. Ikawa; M. Noda Genetic analysis of the Kirsten-ros-revertant 1 gene: Potentiation of its tumor suppressor activity by specific point mutations Genetic analysis of the Kirsten-ros-revertant 1 gene: Potentiation of its tumor suppressor activity by specific point mutations Genetic analysis of the Kirsten-ros-revertant 1 gene: Potentiation of its tumor suppressor activity by specific point mutations Proceedings of the National Academy of Sciences of the United States of America, 87, 11, 4284-4288 Proceedings of the National Academy of Sciences of the United States of America, 87, 11, 4284-4288 Proceedings of the National Academy of Sciences of the United States of America, 87, 11, 4284-4288 1990/06 Refereed English Disclose to all
M. Noda; H. Kitayama; T. Matsuzaki; Y. Sugimoto; H. Okayama; R.H. Bassin; Y. Ikawa M. Noda; H. Kitayama; T. Matsuzaki; Y. Sugimoto; H. Okayama; R.H. Bassin; Y. Ikawa M. Noda; H. Kitayama; T. Matsuzaki; Y. Sugimoto; H. Okayama; R.H. Bassin; Y. Ikawa Detection of genes with a potential for suppressing the transformed phenotype associated with activated ras genes Detection of genes with a potential for suppressing the transformed phenotype associated with activated ras genes Detection of genes with a potential for suppressing the transformed phenotype associated with activated ras genes Proceedings of the National Academy of Sciences of the United States of America, 86, 1, 162-166 Proceedings of the National Academy of Sciences of the United States of America, 86, 1, 162-166 Proceedings of the National Academy of Sciences of the United States of America, 86, 1, 162-166 1989 Refereed English Disclose to all
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医学図書委員 -
ウサギ、ラット小委員会 -
動物実験施設運営委員会 2013/04/01-2019/03/31