松﨑朋子

Last Update: 2020/07/29 13:58:32

Name(Kanji/Kana/Abecedarium Latinum)

松﨑朋子/マツザキトモコ/Matsuzaki, Tomoko

Primary Affiliation(Org1/Job title)

Graduate Schools Medicine/Assistant Professor

Faculty

Org1	Job title
医学部

Academic Organizations You are Affiliated to in Japan

Organization name(Japanese)	Organization name(English)
日本生化学会	The Japanese Biochemical Society
日本癌学会	Japanese Cancer Association
日本分子生物学会	The Molecular Biology Society of Japan

Academic Degree

Field(Japanese)	Field(English)	University(Japanese)	University(English)	Method
博士（医学）	Doctor of Philosophy	東京医科歯科大学	Tokyo Medical and Dental University

Personal Profile

(Japanese)
細胞外で働くたんぱく質がいかに生体の機能を調節しているかを細胞外マトリックスの変化を通して調べています。様々な細胞外マトリックス制御因子が生体そのものの運命を左右している事を良く理解することによって、生命の謎を解き明かすと共に、様々な疾患の治療に役立てればと考えます。
(English)
I stady on regulators of extracelluler matrix remodeling. I am interested in how extracellular stimuli can affect the cell fate and how the cells control their enviroment.

Language of Instruction

Language(japanese)	Language(english)	Code
日本語	Japanese	jpn
英語	English	eng

researchmap URL

https://researchmap.jp/7000008421

Research Topics

(Japanese)
細胞外マトリックス（ECM）制御因子の個体発生、恒常性維持、腫瘍形成における役割解明
(English)
Studies on the roles of extracellular-matrix-regulators in animal development, homeostasis, and tumor suppression.

Overview of the research

(Japanese)
多くのがんで発現が抑制されているがん抑制遺伝子RECKは、マトリックスメタロプロテアーゼ(MMPｓ)抑制、NotchリガンドのADAM10による放出の制御、Wnt7シグナルの増強などの働きを持つことが既に知られている。我々は、新たに、RECKがマウス胎児脳血管形成においてWnt7シグナルのレセプター側（GPR124-FZD-LRP）だけでなくリガンド側（Wnt7）においてもシグナル伝達にとって必須の役割を担う事を見出した。成体マウスを用いた研究では、RECKが下垂体の成長ホルモン（GH）産生細胞で発現されており、成長ホルモン放出ホルモン受容体（GHRHR）やグレリン受容体(GHSR)の安定化に寄与していること、また、肝臓においても成長ホルモン受容体(GHR)の安定化に寄与している事を発見した。また、RECKはマルファン症候群で変異が見られるフィブリリン１（FBN1）と生体内で共発現しており、膜結合型マトリックスメタロプロテアーゼ(MT1-MMP)、メタロプロテアーゼ(ADAMTS10)と共に、FBN1線維形成に重要な役割を演ずる事を見出した。さらに、皮膚線維芽細胞ではRECKがproMT1-MMPを活性化するのに対し、精製したRECKは活性化型MT1-MMPの活性を抑制するという興味深い現象を見出した。これらの知見は、RECKの生理機能やフィブリリン細毛線維形成の分子機構に新たな光を当て、がん、成長障害、結合組織異常などの病態解明に資するものと考えている。
(English)
The tumor suppressor protein RECK has been implicated in the regulation of matrix metalloproteinases (MMPs), Notch-signaling, and WNT7-signaling. We recently found that RECK plays roles essential for vascular development in mouse central nervous system (CNS) not only on the receptor (GPR124-FZD-LRP) side but also on the ligand (Wnt7a/b) side of WNT7-signaling. In adult mouse, RECK is expressed abundantly in growth hormone (GH)-producing cells in anterior pituitary gland. We found that RECK contributes to the stabilization of several receptors involved in the GH-IGF1 axis (i.e., GHRHR, GHSR, GHR). We also found that RECK and fibrillin-1 are coexpressed in many human tissues. Fibrillin-1 mutations are found in Marfan syndrome. Our data suggest that three proteins, RECK, ADAMTS10 (secreted metalloprotease), and MT1-MMP (secreted membrane-bound matrix-metalloprotease) cooperate to support the formation of robust fibrillin-1 fibers. Interestingly, RECK is capable of activating proMT1-MMP in mouse dermal fibroblasts while it inhibits mature MT1-MMP in vitro. These findings shed some new lights on the physiological functions of RECK, the molecular mechanisms of fibrillin fiber formation, and the molecular bases of diseases such as cancer, growth defects, and connective tissue disorders.

Fields of research (key words)

Key words(Japanese)	Key words(English)
分子腫瘍学	molecular oncology
細胞外マトリックス	extracellular-matrix
がん抑制遺伝子	tumor suppressor gene

Published Papers

Author	Author(Japanese)	Author(English)	Title	Title(Japanese)	Title(English)	Bibliography	Bibliography(Japanese)	Bibliography(English)	Publication date	Refereed paper	Language	Publishing type	Disclose
TomokoMatsuzaki, HitoshiKitayama, AkiraOmura, EmiNishimoto, DavidB.Alexander and MakotoNoda	松﨑朋子、北山仁、大村彰、西幹栄美、ディビッドアレクサンダー、野田亮	TomokoMatsuzaki, HitoshiKitayama, AkiraOmura, EmiNishimoto, DavidB.Alexander and MakotoNoda	The RECK tumor suppressor protein binds and stabilizes ADAMTS10	The RECK tumor suppressor protein binds and stabilizes ADAMTS10	The RECK tumor suppressor protein binds and stabilizes ADAMTS10	Biology open, 7, 10	Biology open, 7, 10	Biology open, 7, 10	2018/10	Refereed	English	Research paper(scientific journal)	Disclose to all
Matsuzaki T, Wang H, Imamura Y, Kondo S, Ogawa S, Noda M.		Matsuzaki T, Wang H, Imamura Y, Kondo S, Ogawa S, Noda M.	Generation and characterization of a mouse line carrying Reck-CreERT2 knock-in allele.	Generation and characterization of a mouse line carrying Reck-CreERT2 knock-in allele.	Generation and characterization of a mouse line carrying Reck-CreERT2 knock-in allele.	Genesis, 56, 4, e23099	Genesis, 56, 4, e23099	Genesis, 56, 4, e23099	2018/04	Refereed	English	Research paper(scientific journal)	Disclose to all
Almeida GM, Yamamoto M, Morioka Y, Ogawa S, Matsuzaki T, Noda M.		Almeida GM, Yamamoto M, Morioka Y, Ogawa S, Matsuzaki T, Noda M.	Critical roles for murine Reck in the regulation of vascular patterning and stabilization.	Critical roles for murine Reck in the regulation of vascular patterning and stabilization.	Critical roles for murine Reck in the regulation of vascular patterning and stabilization.	Sci Rep, 5, 17860	Sci Rep, 5, 17860	Sci Rep, 5, 17860	2015	Refereed	English	Research paper(scientific journal)	Disclose to all
Yamamoto M, Matsuzaki T, Takahashi R, Adachi E, Maeda Y, Yamaguchi S, Kitayama H, Echizenya M, Morioka Y, Alexander DB, Yagi T, Itohara S, Nakamura T, Akiyama H, Noda M.		Yamamoto M, Matsuzaki T, Takahashi R, Adachi E, Maeda Y, Yamaguchi S, Kitayama H, Echizenya M, Morioka Y, Alexander DB, Yagi T, Itohara S, Nakamura T, Akiyama H, Noda M.	The transformation suppressor gene Reck is required for postaxial patterning in mouse forelimbs.	The transformation suppressor gene Reck is required for postaxial patterning in mouse forelimbs.	The transformation suppressor gene Reck is required for postaxial patterning in mouse forelimbs.	Biol Open, 1, 458-466	Biol Open, 1, 458-466	Biol Open, 1, 458-466	2012	Refereed	English	Research paper(scientific journal)	Disclose to all
E.P. Chandana; Y. Maeda; A. Ueda; H. Kiyonari; N. Oshima; M. Yamamoto; S. Kondo; J. Oh; R. Takahashi; Y. Yoshida; S. Kawashima; D.B. Alexander; H. Kitayama; C. Takahashi; Y. Tabata; T. Matsuzaki; M. Noda	E.P. Chandana; Y. Maeda; A. Ueda; H. Kiyonari; N. Oshima; M. Yamamoto; S. Kondo; J. Oh; R. Takahashi; Y. Yoshida; S. Kawashima; D.B. Alexander; H. Kitayama; C. Takahashi; Y. Tabata; T. Matsuzaki; M. Noda	E.P. Chandana; Y. Maeda; A. Ueda; H. Kiyonari; N. Oshima; M. Yamamoto; S. Kondo; J. Oh; R. Takahashi; Y. Yoshida; S. Kawashima; D.B. Alexander; H. Kitayama; C. Takahashi; Y. Tabata; T. Matsuzaki; M. Noda	Involvement of the Reck tumor suppressor protein in maternal and embryonic vascular remodeling in mice	Involvement of the Reck tumor suppressor protein in maternal and embryonic vascular remodeling in mice	Involvement of the Reck tumor suppressor protein in maternal and embryonic vascular remodeling in mice	BMC Developmental Biology, 10	BMC Developmental Biology, 10	BMC Developmental Biology, 10	2010/08/06	Refereed	English		Disclose to all
M. Noda; C. Takahashi; T. Matsuzaki; H. Kitayama	M. Noda; C. Takahashi; T. Matsuzaki; H. Kitayama	M. Noda; C. Takahashi; T. Matsuzaki; H. Kitayama	What we learn from transformation suppressor genes: Lessons from RECK	What we learn from transformation suppressor genes: Lessons from RECK	What we learn from transformation suppressor genes: Lessons from RECK	Future Oncology, 6, 7, 1105-1116	Future Oncology, 6, 7, 1105-1116	Future Oncology, 6, 7, 1105-1116	2010/07	Refereed	English		Disclose to all
F. Loayza-Puch; Y. Yoshida; T. Matsuzaki; C. Takahashi; H. Kitayama; M. Noda	F. Loayza-Puch; Y. Yoshida; T. Matsuzaki; C. Takahashi; H. Kitayama; M. Noda	F. Loayza-Puch; Y. Yoshida; T. Matsuzaki; C. Takahashi; H. Kitayama; M. Noda	Hypoxia and RAS-signaling pathways converge on, and cooperatively downregulate, the RECK tumor-suppressor protein through microRNAs	Hypoxia and RAS-signaling pathways converge on, and cooperatively downregulate, the RECK tumor-suppressor protein through microRNAs	Hypoxia and RAS-signaling pathways converge on, and cooperatively downregulate, the RECK tumor-suppressor protein through microRNAs	Oncogene, 29, 18, 2638-2648	Oncogene, 29, 18, 2638-2648	Oncogene, 29, 18, 2638-2648	2010/05/06	Refereed	English		Disclose to all
5. Loayza-Puch, F., Yoshida, Y., Matsuzaki, T., Takahashi, C., Kitayama, H., *Noda,M.:	5. Loayza-Puch, F., Yoshida, Y., Matsuzaki, T., Takahashi, C., Kitayama, H., *Noda,M.:	5. Loayza-Puch, F., Yoshida, Y., Matsuzaki, T., Takahashi, C., Kitayama, H., *Noda,M.:	Hypoxia and RAS signaling pathways converge on, and cooperatively down-regulate, the RECK tumor suppressor protein via microRNAs. Oncogene 2010 2010 May 6;29(18):2638-48. Epub 2010 Feb 15.	Hypoxia and RAS signaling pathways converge on, and cooperatively down-regulate, the RECK tumor suppressor protein via microRNAs. Oncogene 2010 2010 May 6;29(18):2638-48. Epub 2010 Feb 15.	Hypoxia and RAS signaling pathways converge on, and cooperatively down-regulate, the RECK tumor suppressor protein via microRNAs. Oncogene 2010 2010 May 6;29(18):2638-48. Epub 2010 Feb 15.				2010	Refereed	English		Disclose to all
M. Hatta; T. Matsuzaki; Y. Morioka; Y. Yoshida; M. Noda	M. Hatta; T. Matsuzaki; Y. Morioka; Y. Yoshida; M. Noda	M. Hatta; T. Matsuzaki; Y. Morioka; Y. Yoshida; M. Noda	Density- and serum-dependent regulation of the Reck tumor suppressor in mouse embryo fibroblasts	Density- and serum-dependent regulation of the Reck tumor suppressor in mouse embryo fibroblasts	Density- and serum-dependent regulation of the Reck tumor suppressor in mouse embryo fibroblasts	Cellular Signalling, 21, 12, 1885-1893	Cellular Signalling, 21, 12, 1885-1893	Cellular Signalling, 21, 12, 1885-1893	2009/12	Refereed	English		Disclose to all
Y. Morioka; J. Monypenny; T. Matsuzaki; S. Shi; D.B. Alexander; H. Kitayama; M. Noda	Y. Morioka; J. Monypenny; T. Matsuzaki; S. Shi; D.B. Alexander; H. Kitayama; M. Noda	Y. Morioka; J. Monypenny; T. Matsuzaki; S. Shi; D.B. Alexander; H. Kitayama; M. Noda	The membrane-anchored metalloproteinase regulator RECK stabilizes focal adhesions and anterior-posterior polarity in fibroblasts	The membrane-anchored metalloproteinase regulator RECK stabilizes focal adhesions and anterior-posterior polarity in fibroblasts	The membrane-anchored metalloproteinase regulator RECK stabilizes focal adhesions and anterior-posterior polarity in fibroblasts	Oncogene, 28, 11, 1454-1464	Oncogene, 28, 11, 1454-1464	Oncogene, 28, 11, 1454-1464	2009/03	Refereed	English		Disclose to all
A. Omura; T. Matsuzaki; K. Mio; T. Ogura; M. Yamamoto; A. Fujita; K. Okawa; H. Kitayama; C. Takahashi; C. Sato; M. Noda	A. Omura; T. Matsuzaki; K. Mio; T. Ogura; M. Yamamoto; A. Fujita; K. Okawa; H. Kitayama; C. Takahashi; C. Sato; M. Noda	A. Omura; T. Matsuzaki; K. Mio; T. Ogura; M. Yamamoto; A. Fujita; K. Okawa; H. Kitayama; C. Takahashi; C. Sato; M. Noda	RECK forms cowbell-shaped dimers and inhibits matrix metalloproteinase-catalyzed cleavage of fibronectin	RECK forms cowbell-shaped dimers and inhibits matrix metalloproteinase-catalyzed cleavage of fibronectin	RECK forms cowbell-shaped dimers and inhibits matrix metalloproteinase-catalyzed cleavage of fibronectin	Journal of Biological Chemistry, 284, 6, 3461-3469	Journal of Biological Chemistry, 284, 6, 3461-3469	Journal of Biological Chemistry, 284, 6, 3461-3469	2009/02/06	Refereed	English		Disclose to all
Y. Ohne; T. Takahara; R. Hatakeyama; T. Matsuzaki; M. Noda; N. Mizushima; T. Maeda	Y. Ohne; T. Takahara; R. Hatakeyama; T. Matsuzaki; M. Noda; N. Mizushima; T. Maeda	Y. Ohne; T. Takahara; R. Hatakeyama; T. Matsuzaki; M. Noda; N. Mizushima; T. Maeda	Isolation of hyperactive mutants of mammalian target of rapamycin	Isolation of hyperactive mutants of mammalian target of rapamycin	Isolation of hyperactive mutants of mammalian target of rapamycin	Journal of Biological Chemistry, 283, 46, 31861-31870	Journal of Biological Chemistry, 283, 46, 31861-31870	Journal of Biological Chemistry, 283, 46, 31861-31870	2008/11/14	Refereed	English		Disclose to all
T. Matsuzaki; K.-I. Aisaki; Y. Yamamura; M. Noda; Y. Ikawa	T. Matsuzaki; K.-I. Aisaki; Y. Yamamura; M. Noda; Y. Ikawa	T. Matsuzaki; K.-I. Aisaki; Y. Yamamura; M. Noda; Y. Ikawa	Induction of erythroid differentiation by inhibition of Ras/ERK pathway in a Friend murine leukemia cell line	Induction of erythroid differentiation by inhibition of Ras/ERK pathway in a Friend murine leukemia cell line	Induction of erythroid differentiation by inhibition of Ras/ERK pathway in a Friend murine leukemia cell line	Oncogene, 19, 12, 1500-1508	Oncogene, 19, 12, 1500-1508	Oncogene, 19, 12, 1500-1508	2000	Refereed	English		Disclose to all
Y. Yamamura; H. Senda; Y. Kageyama; T. Matsuzaki; M. Noda; Y. Ikawa	Y. Yamamura; H. Senda; Y. Kageyama; T. Matsuzaki; M. Noda; Y. Ikawa	Y. Yamamura; H. Senda; Y. Kageyama; T. Matsuzaki; M. Noda; Y. Ikawa	Erythropoietin and Friend virus gp55 activate different JAK/STAT pathways through the erythropoietin receptor in erythroid cells	Erythropoietin and Friend virus gp55 activate different JAK/STAT pathways through the erythropoietin receptor in erythroid cells	Erythropoietin and Friend virus gp55 activate different JAK/STAT pathways through the erythropoietin receptor in erythroid cells	Molecular and Cellular Biology, 18, 3, 1172-1180	Molecular and Cellular Biology, 18, 3, 1172-1180	Molecular and Cellular Biology, 18, 3, 1172-1180	1998	Refereed	English		Disclose to all
C. Takahashi; N. Akiyama; T. Matsuzaki; S. Takai; H. Kitayama; M. Noda	C. Takahashi; N. Akiyama; T. Matsuzaki; S. Takai; H. Kitayama; M. Noda	C. Takahashi; N. Akiyama; T. Matsuzaki; S. Takai; H. Kitayama; M. Noda	Characterization of a human MSX-2 cDNA and its fragment isolated as a transformation suppressor gene against v-Ki-ras oncogene	Characterization of a human MSX-2 cDNA and its fragment isolated as a transformation suppressor gene against v-Ki-ras oncogene	Characterization of a human MSX-2 cDNA and its fragment isolated as a transformation suppressor gene against v-Ki-ras oncogene	Oncogene, 12, 10, 2137-2146	Oncogene, 12, 10, 2137-2146	Oncogene, 12, 10, 2137-2146	1996	Refereed	English		Disclose to all
S. Murata; T. Matsuzaki; S. Takai; H. Yaoita; M. Noda	S. Murata; T. Matsuzaki; S. Takai; H. Yaoita; M. Noda	S. Murata; T. Matsuzaki; S. Takai; H. Yaoita; M. Noda	A new retroviral vector for detecting mutations and chromosomal instability in mammalian cells	A new retroviral vector for detecting mutations and chromosomal instability in mammalian cells	A new retroviral vector for detecting mutations and chromosomal instability in mammalian cells	Mutation Research/Environmental Mutagenesis and Related Subjects, 334, 3, 375-383	Mutation Research/Environmental Mutagenesis and Related Subjects, 334, 3, 375-383	Mutation Research/Environmental Mutagenesis and Related Subjects, 334, 3, 375-383	1995	Refereed	English		Disclose to all
S. Kumar; T. Matsuzaki; Y. Yoshida; M. Noda	S. Kumar; T. Matsuzaki; Y. Yoshida; M. Noda	S. Kumar; T. Matsuzaki; Y. Yoshida; M. Noda	Molecular cloning and biological activity of a novel developmentally regulated gene encoding a protein with β-transducin-like structure	Molecular cloning and biological activity of a novel developmentally regulated gene encoding a protein with β-transducin-like structure	Molecular cloning and biological activity of a novel developmentally regulated gene encoding a protein with β-transducin-like structure	Journal of Biological Chemistry, 269, 15, 11318-11326	Journal of Biological Chemistry, 269, 15, 11318-11326	Journal of Biological Chemistry, 269, 15, 11318-11326	1994	Refereed	English		Disclose to all
H. Kitayama; T. Matsuzaki; Y. Sugimoto; Y. Ikawa; M. Noda	H. Kitayama; T. Matsuzaki; Y. Sugimoto; Y. Ikawa; M. Noda	H. Kitayama; T. Matsuzaki; Y. Sugimoto; Y. Ikawa; M. Noda	Genetic analysis of the K-rev-1 transformation-suppressor gene	Genetic analysis of the K-rev-1 transformation-suppressor gene	Genetic analysis of the K-rev-1 transformation-suppressor gene	Environmental Health Perspectives, 93, 73-77	Environmental Health Perspectives, 93, 73-77	Environmental Health Perspectives, 93, 73-77	1991	Refereed	English		Disclose to all
H. Kitayama; T. Matsuzaki; Y. Ikawa; M. Noda	H. Kitayama; T. Matsuzaki; Y. Ikawa; M. Noda	H. Kitayama; T. Matsuzaki; Y. Ikawa; M. Noda	A domain responsible for the transformation suppressor activity in Krev-1 protein	A domain responsible for the transformation suppressor activity in Krev-1 protein	A domain responsible for the transformation suppressor activity in Krev-1 protein	Japanese Journal of Cancer Research, 81, 5, 445-448	Japanese Journal of Cancer Research, 81, 5, 445-448	Japanese Journal of Cancer Research, 81, 5, 445-448	1990/05	Refereed	English		Disclose to all
H. Kitayama; Y. Sugimoto; T. Matsuzaki; Y. Ikawa; M. Noda	H. Kitayama; Y. Sugimoto; T. Matsuzaki; Y. Ikawa; M. Noda	H. Kitayama; Y. Sugimoto; T. Matsuzaki; Y. Ikawa; M. Noda	A ras-related gene with transformation suppressor activity	A ras-related gene with transformation suppressor activity	A ras-related gene with transformation suppressor activity	Cell, 56, 1, 77-84	Cell, 56, 1, 77-84	Cell, 56, 1, 77-84	1989/01/13	Refereed	English		Disclose to all
M. Noda; H. Kitayama; S. Kanazawa; S. Murata; T. Matsuzaki; Y. Ikawa	M. Noda; H. Kitayama; S. Kanazawa; S. Murata; T. Matsuzaki; Y. Ikawa	M. Noda; H. Kitayama; S. Kanazawa; S. Murata; T. Matsuzaki; Y. Ikawa	Transformation suppressor genes.	Transformation suppressor genes.	Transformation suppressor genes.	Princess Takamatsu symposia, 20, 233-239	Princess Takamatsu symposia, 20, 233-239	Princess Takamatsu symposia, 20, 233-239	1989	Refereed	English		Disclose to all
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Misc

Author	Author(Japanese)	Author(English)	Title	Title(Japanese)	Title(English)	Bibliography	Bibliography(Japanese)	Bibliography(English)	Publication date	Refereed paper	Language	Disclose
H. Kitayama; T. Matsuzaki; Y. Ikawa; M. Noda	H. Kitayama; T. Matsuzaki; Y. Ikawa; M. Noda	H. Kitayama; T. Matsuzaki; Y. Ikawa; M. Noda	Genetic analysis of the Kirsten-ros-revertant 1 gene: Potentiation of its tumor suppressor activity by specific point mutations	Genetic analysis of the Kirsten-ros-revertant 1 gene: Potentiation of its tumor suppressor activity by specific point mutations	Genetic analysis of the Kirsten-ros-revertant 1 gene: Potentiation of its tumor suppressor activity by specific point mutations	Proceedings of the National Academy of Sciences of the United States of America, 87, 11, 4284-4288	Proceedings of the National Academy of Sciences of the United States of America, 87, 11, 4284-4288	Proceedings of the National Academy of Sciences of the United States of America, 87, 11, 4284-4288	1990/06	Refereed	English	Disclose to all
M. Noda; H. Kitayama; T. Matsuzaki; Y. Sugimoto; H. Okayama; R.H. Bassin; Y. Ikawa	M. Noda; H. Kitayama; T. Matsuzaki; Y. Sugimoto; H. Okayama; R.H. Bassin; Y. Ikawa	M. Noda; H. Kitayama; T. Matsuzaki; Y. Sugimoto; H. Okayama; R.H. Bassin; Y. Ikawa	Detection of genes with a potential for suppressing the transformed phenotype associated with activated ras genes	Detection of genes with a potential for suppressing the transformed phenotype associated with activated ras genes	Detection of genes with a potential for suppressing the transformed phenotype associated with activated ras genes	Proceedings of the National Academy of Sciences of the United States of America, 86, 1, 162-166	Proceedings of the National Academy of Sciences of the United States of America, 86, 1, 162-166	Proceedings of the National Academy of Sciences of the United States of America, 86, 1, 162-166	1989	Refereed	English	Disclose to all
Title language:

Faculty management (title, position)

Title	Period
医学図書委員	-
ウサギ、ラット小委員会	-
動物実験施設運営委員会	2013/04/01-2019/03/31

松﨑 朋子

松﨑朋子