大槻元

Last Update: 2019/09/25 18:11:33

Name(Kanji/Kana/Abecedarium Latinum)

大槻元/オオツキゲン/Ohtsuki, Gen

Primary Affiliation(Org1/Job title)

Graduate Schools Medicine/Program-Specific Professor

Academic Degree

Field(Japanese)	Field(English)	University(Japanese)	University(English)	Method
修士（理学）		京都大学
博士（理学)		京都大学

ORCID ID

https://orcid.org/0000-0003-3004-5886

researchmap URL

https://researchmap.jp/7000011336

Published Papers

Author	Author(Japanese)	Author(English)	Title	Title(Japanese)	Title(English)	Bibliography	Bibliography(Japanese)	Bibliography(English)	Publication date	Refereed paper	Language	Publishing type	Disclose
Gen Ohtsuki, Masamichi Yamamoto, Minsoo Kim, Hirohiko Imai, Yamato Itakura		Gen Ohtsuki, Masamichi Yamamoto, Minsoo Kim, Hirohiko Imai, Yamato Itakura	Microglia-triggered plasticity of intrinsic excitability modulates psychomotor behaviors in acute cerebellar inflammation	Microglia-triggered plasticity of intrinsic excitability modulates psychomotor behaviors in acute cerebellar inflammation	Microglia-triggered plasticity of intrinsic excitability modulates psychomotor behaviors in acute cerebellar inflammation	Cell Reports, 28, 11, 2923-2938.e8	Cell Reports, 28, 11, 2923-2938.e8	, 28, 11, 2923-2938.e8	2019/09	Refereed	English	Research paper(scientific journal)	Disclose to all
Yamamoto M, Kim M, Imai H, Ohtsuki G		Yamamoto M, Kim M, Imai H, Ohtsuki G	Microglia-triggered hyperexcitability in the cerebellum depresses animal behaviors	Microglia-triggered hyperexcitability in the cerebellum depresses animal behaviors	Microglia-triggered hyperexcitability in the cerebellum depresses animal behaviors	bioRxiv	bioRxiv	bioRxiv	2018/06		English	Research paper(scientific journal)	Disclose to all
Ohtsuki G and C Hansel	Ohtsuki G and C Hansel	Ohtsuki G and C Hansel	Synaptic drive and plasticity of an SK2 channel gate determine spike burst activity in cerebellar Purkinje cells	Synaptic drive and plasticity of an SK2 channel gate determine spike burst activity in cerebellar Purkinje cells	Synaptic drive and plasticity of an SK2 channel gate determine spike burst activity in cerebellar Purkinje cells	iScience, 1, 1, 49-54	iScience, 1, 1, 49-54	iScience, 1, 1, 49-54	2018/03	Refereed	English	Research paper(scientific journal)	Disclose to all
Grasselli G, He Q, Wan V, Adelman J.P, Ohtsuki G, Hansel C.	Grasselli G, He Q, Wan V, Adelman J.P, Ohtsuki G, Hansel C.	Grasselli G, He Q, Wan V, Adelman J.P, Ohtsuki G, Hansel C.	Activity-Dependent Plasticity of Spike Pauses in Cerebellar Purkinje Cells	Activity-Dependent Plasticity of Spike Pauses in Cerebellar Purkinje Cells	Activity-Dependent Plasticity of Spike Pauses in Cerebellar Purkinje Cells	Cell Reports, 14, 11, 2546-2553	Cell Reports, 14, 11, 2546-2553	Cell Reports, 14, 11, 2546-2553	2016	Refereed			Disclose to all
Shih E.K, Sekerkov{\'a} G, Ohtsuki G, Aldinger K.A, Chizhikov V.V, Hansel C, Mugnaini E, Millen K.J.	Shih E.K, Sekerkov{\'a} G, Ohtsuki G, Aldinger K.A, Chizhikov V.V, Hansel C, Mugnaini E, Millen K.J.	Shih E.K, Sekerkov{\'a} G, Ohtsuki G, Aldinger K.A, Chizhikov V.V, Hansel C, Mugnaini E, Millen K.J.	The Spontaneous Ataxic Mouse Mutant Tippy is Characterized by a Novel Purkinje Cell Morphogenesis and Degeneration Phenotype	The Spontaneous Ataxic Mouse Mutant Tippy is Characterized by a Novel Purkinje Cell Morphogenesis and Degeneration Phenotype	The Spontaneous Ataxic Mouse Mutant Tippy is Characterized by a Novel Purkinje Cell Morphogenesis and Degeneration Phenotype	Cerebellum, 14, 3, 292-307	Cerebellum, 14, 3, 292-307	Cerebellum, 14, 3, 292-307	2015	Refereed			Disclose to all
Ohtsuki G, Piochon C, Adelman J.P, Hansel C.	Ohtsuki G, Piochon C, Adelman J.P, Hansel C.	Ohtsuki G, Piochon C, Adelman J.P, Hansel C.	SK2 channel modulation contributes to compartment-specific dendritic plasticity in cerebellar Purkinje cells	SK2 channel modulation contributes to compartment-specific dendritic plasticity in cerebellar Purkinje cells	SK2 channel modulation contributes to compartment-specific dendritic plasticity in cerebellar Purkinje cells	Neuron, 75, 1, 108-120	Neuron, 75, 1, 108-120	Neuron, 75, 1, 108-120	2012	Refereed			Disclose to all
Ohtsuki G, Nishiyama M, Yoshida T, Murakami T, Histed M, Lois C, Ohki K.	Ohtsuki G, Nishiyama M, Yoshida T, Murakami T, Histed M, Lois C, Ohki K.	Ohtsuki G, Nishiyama M, Yoshida T, Murakami T, Histed M, Lois C, Ohki K.	Similarity of visual selectivity among clonally related neurons in visual cortex	Similarity of visual selectivity among clonally related neurons in visual cortex	Similarity of visual selectivity among clonally related neurons in visual cortex	Neuron, 75, 1, 65-72	Neuron, 75, 1, 65-72	Neuron, 75, 1, 65-72	2012	Refereed			Disclose to all
Belmeguenai A, Hosy E, Bengtsson F, Pedroarena C.M, Piochon C, Teuling E, He Q, Ohtsuki G, De Jeu M.T.G, Elgersma Y, De Zeeuw C.I, J{\"o}rntell H, Hansel C.	Belmeguenai A, Hosy E, Bengtsson F, Pedroarena C.M, Piochon C, Teuling E, He Q, Ohtsuki G, De Jeu M.T.G, Elgersma Y, De Zeeuw C.I, J{\"o}rntell H, Hansel C.	Belmeguenai A, Hosy E, Bengtsson F, Pedroarena C.M, Piochon C, Teuling E, He Q, Ohtsuki G, De Jeu M.T.G, Elgersma Y, De Zeeuw C.I, J{\"o}rntell H, Hansel C.	Intrinsic plasticity complements long-term potentiation in parallel fiber input gain control in cerebellar Purkinje cells	Intrinsic plasticity complements long-term potentiation in parallel fiber input gain control in cerebellar Purkinje cells	Intrinsic plasticity complements long-term potentiation in parallel fiber input gain control in cerebellar Purkinje cells	Journal of Neuroscience, 30, 41, 13630-13643	Journal of Neuroscience, 30, 41, 13630-13643	Journal of Neuroscience, 30, 41, 13630-13643	2010	Refereed			Disclose to all
Piochon C, Levenes C, Ohtsuki G, Hansel C.	Piochon C, Levenes C, Ohtsuki G, Hansel C.	Piochon C, Levenes C, Ohtsuki G, Hansel C.	Purkinje cell NMDA receptors assume a key role in synaptic gain control in the mature cerebellum	Purkinje cell NMDA receptors assume a key role in synaptic gain control in the mature cerebellum	Purkinje cell NMDA receptors assume a key role in synaptic gain control in the mature cerebellum	Journal of Neuroscience, 30, 45, 15330-15335	Journal of Neuroscience, 30, 45, 15330-15335	Journal of Neuroscience, 30, 45, 15330-15335	2010	Refereed			Disclose to all
Schonewille M, Belmeguenai A, Koekkoek S.K, Houtman S.H, Boele H.J, van Beugen B.J, Gao Z, Badura A, Ohtsuki G, Amerika W.E, Hosy E, Hoebeek F.E, Elgersma Y, Hansel C, De Zeeuw C.I.	Schonewille M, Belmeguenai A, Koekkoek S.K, Houtman S.H, Boele H.J, van Beugen B.J, Gao Z, Badura A, Ohtsuki G, Amerika W.E, Hosy E, Hoebeek F.E, Elgersma Y, Hansel C, De Zeeuw C.I.	Schonewille M, Belmeguenai A, Koekkoek S.K, Houtman S.H, Boele H.J, van Beugen B.J, Gao Z, Badura A, Ohtsuki G, Amerika W.E, Hosy E, Hoebeek F.E, Elgersma Y, Hansel C, De Zeeuw C.I.	Purkinje cell-specific knockout of the protein phosphatase PP2B impairs potentiation and cerebellar motor learning	Purkinje cell-specific knockout of the protein phosphatase PP2B impairs potentiation and cerebellar motor learning	Purkinje cell-specific knockout of the protein phosphatase PP2B impairs potentiation and cerebellar motor learning	Neuron, 67, 4, 618-628	Neuron, 67, 4, 618-628	Neuron, 67, 4, 618-628	2010	Refereed			Disclose to all
Ohtsuki G, Piochon C, Hansel C.	Ohtsuki G, Piochon C, Hansel C.	Ohtsuki G, Piochon C, Hansel C.	Climbing fiber signaling and cerebellar gain control	Climbing fiber signaling and cerebellar gain control	Climbing fiber signaling and cerebellar gain control	Frontiers in Cellular Neuroscience, 3, JUL	Frontiers in Cellular Neuroscience, 3, JUL	Frontiers in Cellular Neuroscience, 3, JUL	2009	Refereed			Disclose to all
Ohtsuki G, Hirano T.	Ohtsuki G, Hirano T.	Ohtsuki G, Hirano T.	Bidirectional plasticity at developing climbing fiber-Purkinje neuron synapses	Bidirectional plasticity at developing climbing fiber-Purkinje neuron synapses	Bidirectional plasticity at developing climbing fiber-Purkinje neuron synapses	European Journal of Neuroscience, 28, 12, 2393-2400	European Journal of Neuroscience, 28, 12, 2393-2400	European Journal of Neuroscience, 28, 12, 2393-2400	2008	Refereed			Disclose to all
Takeuchi T, Ohtsuki G, Yoshida T, Fukaya M, Wainai T, Yamashita M, Yamazaki Y, Mori H, Sakimura K, Kawamoto S, Watanabe M, Hirano T, Mishina M.	Takeuchi T, Ohtsuki G, Yoshida T, Fukaya M, Wainai T, Yamashita M, Yamazaki Y, Mori H, Sakimura K, Kawamoto S, Watanabe M, Hirano T, Mishina M.	Takeuchi T, Ohtsuki G, Yoshida T, Fukaya M, Wainai T, Yamashita M, Yamazaki Y, Mori H, Sakimura K, Kawamoto S, Watanabe M, Hirano T, Mishina M.	Enhancement of both long-term depression induction and optokinetic response adaptation in mice lacking delphilin	Enhancement of both long-term depression induction and optokinetic response adaptation in mice lacking delphilin	Enhancement of both long-term depression induction and optokinetic response adaptation in mice lacking delphilin	PLoS ONE, 3, 5	PLoS ONE, 3, 5	PLoS ONE, 3, 5	2008	Refereed			Disclose to all
Ohtsuki G, Kawaguchi S.-Y, Mishina M, Hirano T.	Ohtsuki G, Kawaguchi S.-Y, Mishina M, Hirano T.	Ohtsuki G, Kawaguchi S.-Y, Mishina M, Hirano T.	Enhanced inhibitory synaptic transmission in the cerebellar molecular layer of the GluRδ2 knock-out mouse	Enhanced inhibitory synaptic transmission in the cerebellar molecular layer of the GluRδ2 knock-out mouse	Enhanced inhibitory synaptic transmission in the cerebellar molecular layer of the GluRδ2 knock-out mouse	Journal of Neuroscience, 24, 48, 10900-10907	Journal of Neuroscience, 24, 48, 10900-10907	Journal of Neuroscience, 24, 48, 10900-10907	2004	Refereed			Disclose to all
Yoskida T, Katoh A, Ohtsuki G, Mishina M, Hirano T.	Yoskida T, Katoh A, Ohtsuki G, Mishina M, Hirano T.	Yoskida T, Katoh A, Ohtsuki G, Mishina M, Hirano T.	Oscillating Purkinje Neuron Activity Causing Involuntary Eye Movement in a Mutant Mouse Deficient in the Glutamate Receptor δ2 Subunit	Oscillating Purkinje Neuron Activity Causing Involuntary Eye Movement in a Mutant Mouse Deficient in the Glutamate Receptor δ2 Subunit	Oscillating Purkinje Neuron Activity Causing Involuntary Eye Movement in a Mutant Mouse Deficient in the Glutamate Receptor δ2 Subunit	Journal of Neuroscience, 24, 10, 2440-2448	Journal of Neuroscience, 24, 10, 2440-2448	Journal of Neuroscience, 24, 10, 2440-2448	2004	Refereed			Disclose to all
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Conference Activities & Talks

Title	Title(Japanese)	Title(English)	Conference	Conference(Japanese)	Conference(English)	Promotor	Promotor(Japanese)	Date	Language	Assortment	Disclose
Excitability plasticity and mental depressiveness during acute inflammation in the cerebellum[Invited]	Excitability plasticity and mental depressiveness during acute inflammation in the cerebellum [Invited]	Excitability plasticity and mental depressiveness during acute inflammation in the cerebellum [Invited]	WMU-IFAR, Wenzhou Medical University Institute for Advanced Research	温州医科大学高等研究院学内招待講演	WMU-IFAR, Wenzhou Medical University Institute for Advanced Research	Jian Yang and Zi-Bing JIN	Jian Yang and Zi-Bing JIN	2019/09/15	English	Public discourse, seminar, tutorial, course, lecture and others	Disclose to all
Functional Diversification in Clonal Cells after Eye-Opening in Mouse Visual Cortex	Functional Diversification in Clonal Cells after Eye-Opening in Mouse Visual Cortex	Functional Diversification in Clonal Cells after Eye-Opening in Mouse Visual Cortex	京都大学大学院理学研究科ミニシンポジウム	京都大学大学院理学研究科ミニシンポジウム		田川義晃	田川義晃	2015/07	English	Symposium workshop panel(nominated)	Disclose to all
Functional organization of clonally related neurons in mouse visual cortex during development	Functional organization of clonally related neurons in mouse visual cortex during development	Functional organization of clonally related neurons in mouse visual cortex during development	日本神経科学学会	日本神経科学学会		日本神経科学学会	日本神経科学学会	2013/07	English	Oral presentation(general)	Disclose to all
Activity-dependent control of signaling gains in neuronal dendrites	Activity-dependent control of signaling gains in neuronal dendrites	Activity-dependent control of signaling gains in neuronal dendrites	Gordon Research Seminar Dendrites: Molecules, Structure & Function	ゴードンリサーチセミナー	Gordon Research Seminar Dendrites: Molecules, Structure & Function	Georgeann S. Sack and Denise Cook	Georgeann S. Sack and Denise Cook	2011/03/12	English	Oral presentation(general)	Disclose to all
Long-term plasticity at cerebellar climbing fiber-Purkinje cell synapses[Invited]	Long-term plasticity at cerebellar climbing fiber-Purkinje cell synapses [Invited]	Long-term plasticity at cerebellar climbing fiber-Purkinje cell synapses [Invited]	Long-term plasticity at cerebellar climbing fiber-Purkinje cell synapses	Long-term plasticity at cerebellar climbing fiber-Purkinje cell synapses	Long-term plasticity at cerebellar climbing fiber-Purkinje cell synapses	ノースウエスタン大学医学部	ノースウエスタン大学医学部	2010	English		Disclose to all
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Books etc

Author	Author(Japanese)	Author(English)	Title	Title(Japanese)	Title(English)	Publisher	Publisher(Japanese)	Publisher(English)	Publication date	Language	Type	Disclose
Gen Ohtsuki	大槻元	Gen Ohtsuki	Modulation of the neural function based on the plasticity of intrinsic excitability in the cerebellum	小脳興奮性可塑性に基づく神経細胞機能変化	Modulation of the neural function based on the plasticity of intrinsic excitability in the cerebellum	(公財)ブレインサイエンス振興財団	(公財)ブレインサイエンス振興財団		2019/06		Contributor	Disclose to all
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Newspaper articles

Title	Media name	Column name	Date
An overactive cerebellum causes issues across the brain	EurekAlert! AAAS	ウェブニュース	2019/09/10
我们发现了小脑出现炎症时由脑的可塑性而引起的类抑郁症状或类自闭症状的产生机理	EurekAlert! AAAS	ウェブニュース	2019/09/10
An overactive cerebellum causes issues across the brain	SCIENCE Codex	ウェブニュース	2019/09/10
小脳の炎症でうつ発生、過度な免疫抑えて回復　京大が発見	日刊工業新聞	ウェブニュース	2019/09/11
An overactive cerebellum causes issues across the brain	Medical Xpress	ウェブニュース	2019/09/10
京大、小脳炎症時の神経活動の過興奮によって鬱様症状が起こる仕組みを解明	日本経済新聞	ウェブニュース	2019/09/11
小脳炎症での精神不調一端解明京大、ラット実験	京都新聞（紙面）	朝刊社３	2019/09/12
小脳炎症で精神不調来す仕組み解明京大グループ、ラット実験で	京都新聞	ウェブニュース	2019/09/12
小脳炎症で精神不調来す仕組み解明　京大グループ、ラット実験で	Yahoo ニュース	ウェブニュース	2019/09/12
小脳炎症によるうつ様症状を、免疫抑制で回復させることに成功—京大	医療NEWS QLifePro	ウェブニュース	2019/09/13
An Overactive Cerebellum Causes Widespread Problems Across the Brain	NNR\| Neuroscience News & Research from TECHNOLOGY NETWORKS	ウェブニュース	2019/09/12
Acute cerebellar inflammation create a temporary decrease in motivation and sociability	Debug Lies News	ウェブニュース	2019/09/10
Un estudio desvela que un cerebelo hiperactivo puede provocar comportamientos depresivos	EUROPA PRESS　20minutos	ウェブニュース	2019/09/11
Estudio desvela que un cerebelo hiperactivo provoca depresion	Salud y belleza	ウェブニュース	2019/09/11
小脑过度活跃，会引起整个大脑的问题	腾讯新闻	ウェブニュース	2019/09/11
小脑过度活跃，会引起整个大脑的问题	中国生物技术网	ウェブニュース	2019/09/11
小脑过度活跃，会引起整个大脑的问题	东方都市网	ウェブニュース	2019/09/12
大鼠研究：过度活跃的小脑会引起整个大脑的问题	艾德医讯	ウェブニュース	2019/09/15
乐普医疗股票-Cell Rep: 小脑过度活跃，会引起整个大脑的问题	医疗频道	ウェブニュース	2019/09/14
大鼠研究：過度活躍的小腦會引起整個大腦的問題	每日頭條	ウェブニュース	2019/09/15
小脳炎症時の神経活動の過興奮によって鬱様症状が起こる仕組みを解明	テック・アイ技術情報研究所ウェブサイト	ウェブニュース	2019/09/11
La unión entre cerebelo y depresión	JAEN, spain	ウェブニュース	2019/09/16
A Connection Between Motivation and Brain Inflammation	Psychology Today	ウェブニュース	2019/09/14
Acute cerebellar inflammation and hyperexcitability induces ‘depression-like’ behavior	Neuroscience News	ウェブニュース	2019/09/13
Estudio revela que un cerebelo hiperactivo induce un comportamiento similar a la depresión	La Bandera Noticias: News	ウェブニュース	2019/09/17
Estudio revela que un cerebelo hiperactivo induce un comportamiento similar a la depression	sinembargo.mx	ウェブニュース	2019/09/17
小脳炎症時の神経活動の過興奮によって鬱様症状が起こる仕組みを解明	日本の研究.com	ウェブニュース	2019/09/11
Un estudio desvela que un cerebelo hiperactivo puede provocar comportamientos depresivos	Ver más en	ウェブニュース	2019/09/11
Un estudio desvela que un cerebelo hiperactivo puede provocar comportamientos depresivos	BIENESTAR, COMIDA, NOTICIAS24MX	ウェブニュース	2019/09/11
Un estudio desvela que un cerebelo hiperactivo puede provocar comportamientos depresivos	NOTICIAS SIN	ウェブニュース	2019/09/12
小脳で炎症　うつ症状に京大チーム、ラットで確認	読売新聞（紙面）	朝刊 19ページ科学	2019/09/20
小脳の急性炎症による『心のはたらき』の不調とその回復	一般社団法人日本生理学会（ホームページ記事）	サイエンストピック 130	2019/09/12
Acute cerebellar inflammation and cerebellar hyperexcitability may cause depressive-like behaviors	The Physiological Society of Japan	Science Topics – 130	2019/09/20
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External funds: competitive funds and Grants-in-Aid for Scientific Research (Kakenhi)

Type	Position	Title(Japanese)	Period
若手研究（Ａ）	Representative	大脳皮質視覚野における同一神経幹細胞由来機能相同性配列の発達の解析（平成27年度分）	2015/04/01-2016/03/31
若手研究(A)	Representative	大脳皮質視覚野における同一神経幹細胞由来機能相同性配列の発達の解析（平成28年度分）	2016/04/01-2017/03/31
若手研究(A)	Representative	大脳皮質視覚野における同一神経幹細胞由来機能相同性配列の発達の解析（平成29年度分）	2017/04/01-2018/03/31

Teaching subject(s)

Name(Japanese)	Name(English)	Term	Department	Period
統合生命科学	Interdisciplinary Life Science Course	後期	理学研究科	2015/04-2016/03
統合生命科学	Interdisciplinary Life Science Course	後期	理学研究科	2016/04-2017/03
統合生命科学	Interdisciplinary Life Science Course	後期	理学研究科	2017/04-2018/03

大槻 元

大槻元