佐々木 克博

Last Update: 2019/06/17 18:53:07

Print

Name(Kanji/Kana/Abecedarium Latinum)
佐々木 克博/ササキ カツヒロ/Sasaki, Katsuhiro
Primary Affiliation(Org1/Job title)
Graduate Schools Medicine/Senior Lecturer/ Junior Associate Professor
Faculty
Org1 Job title
医学部
Academic Degree
Field(Japanese) Field(English) University(Japanese) University(English) Method
修士(生命科学) 東京大学
博士(生命科学) 東京大学
researchmap URL
https://researchmap.jp/7000009703
Research Topics
(Japanese)
免疫疾患・腫瘍形成に係るユビキチンネットワーク機構の解明
(English)
Pathophysiological significance of ubiquitin-mediated intracellular network on immune-mediated diseases and cancer
Overview of the research
(Japanese)
ユビキチンは単独もしくは数珠上に連なった鎖状としてタンパク質に修飾され、タンパク質の量的な恒常性の維持や、シグナル伝達ネットワークへの関与等多様な細胞内プロセスに関与する。研究では、主にマウスを利用し、ユビキチン修飾系が、免疫疾患の発症や腫瘍化といった病態形成過程において、どのような役割を有するか明確な答えを導き出すことを目的としている。
(English)
Ubiquitin is a small modifer conjugated on its substrates as monomers or homopolymers (chains) that critically regulates various intracellular events including protein degradation, cell cycle, and signaling pathway. Our interests focus on the ubiquitin-mediated mechanisms on immune-mediated disease and tumor development.
Fields of research (key words)
Key words(Japanese) Key words(English)
ユビキチン Ubiquitin
炎症 Inflammation
LUBAC LUBAC
直鎖状ユビキチン Linear ubiqitination
Cancer
自己免疫疾患 Autoimmunity
Published Papers
Author Author(Japanese) Author(English) Title Title(Japanese) Title(English) Bibliography Bibliography(Japanese) Bibliography(English) Publication date Refereed paper Language Publishing type Disclose
Stadinski BD, Shekhar K, Gómez-Touriño I, Jung J, Sasaki K, Sewell AK, Peakman M, Chakraborty AK, Huseby ES. Stadinski BD, Shekhar K, Gómez-Touriño I, Jung J, Sasaki K, Sewell AK, Peakman M, Chakraborty AK, Huseby ES. Stadinski BD, Shekhar K, Gómez-Touriño I, Jung J, Sasaki K, Sewell AK, Peakman M, Chakraborty AK, Huseby ES. Hydrophobic CDR3 residues promote the development of self-reactive T cells. Hydrophobic CDR3 residues promote the development of self-reactive T cells. Hydrophobic CDR3 residues promote the development of self-reactive T cells. Nat Immunol., 17, 8, 946-955 Nat Immunol., 17, 8, 946-955 Nat Immunol., 17, 8, 946-955 2016/08 Refereed English Research paper(scientific journal) Disclose to all
Huseby ES, Kamimura D, Arima Y, Parello CS, Sasaki K, Murakami M. Huseby ES, Kamimura D, Arima Y, Parello CS, Sasaki K, Murakami M. Huseby ES, Kamimura D, Arima Y, Parello CS, Sasaki K, Murakami M. Huseby ES, Kamimura D, Arima Y, Parello CS, Sasaki K, Murakami M. Role of T cell-glial cell interactions in creating and amplifying central nervous system inflammation and multiple scleårosis disease symptoms. Huseby ES, Kamimura D, Arima Y, Parello CS, Sasaki K, Murakami M. Front Cell Neurosci., 9, 295 Front Cell Neurosci., 9, 295 Front Cell Neurosci., 9, 295 2015/08 Refereed English Research paper(scientific journal) Disclose to all
Sasaki K, Iwai K. Sasaki K, Iwai K. Sasaki K, Iwai K. Roles of linear ubiquitinylation, a crucial regulator of NF-κB and cell death, in the immune system. Roles of linear ubiquitinylation, a crucial regulator of NF-κB and cell death, in the immune system. Roles of linear ubiquitinylation, a crucial regulator of NF-κB and cell death, in the immune system. Immunol Rev., 266, 1, 175-189 Immunol Rev., 266, 1, 175-189 Immunol Rev., 266, 1, 175-189 2015/07 Refereed English Research paper(scientific journal) Disclose to all
Sasaki K, Takada K, Ohte Y, Kondo H, Sorimachi H, Tanaka K, Takahama Y, Murata S. Sasaki K, Takada K, Ohte Y, Kondo H, Sorimachi H, Tanaka K, Takahama Y, Murata S. Sasaki K, Takada K, Ohte Y, Kondo H, Sorimachi H, Tanaka K, Takahama Y, Murata S. Thymoproteasomes produce unique peptide motifs for positive selection of CD8(+) T cells. Thymoproteasomes produce unique peptide motifs for positive selection of CD8(+) T cells. Thymoproteasomes produce unique peptide motifs for positive selection of CD8(+) T cells. Nat Commun., 6, 7484 Nat Commun., 6, 7484 Nat Commun., 6, 7484 2015/06 Refereed English Research paper(scientific journal) Disclose to all
Cho Y, Hori M, Okoshi Y, Fujisawa F, Shinagawa A, Kudo D, Komeno T, Yoshida C, Katsura Y, Ota I, Shimizu S, Kamoshita M, Sasaki K, Tanaka K, Mukai HY, Kojima H. Cho Y, Hori M, Okoshi Y, Fujisawa F, Shinagawa A, Kudo D, Komeno T, Yoshida C, Katsura Y, Ota I, Shimizu S, Kamoshita M, Sasaki K, Tanaka K, Mukai HY, Kojima H. Cho Y, Hori M, Okoshi Y, Fujisawa F, Shinagawa A, Kudo D, Komeno T, Yoshida C, Katsura Y, Ota I, Shimizu S, Kamoshita M, Sasaki K, Tanaka K, Mukai HY, Kojima H. Measurement of Proteasome Activity in Peripheral Blood Mononuclear Cells as an Indicator of Susceptibility to Bortezomib-Induced Severe Neurological Adverse Events in Patients with Multiple Myeloma. Measurement of Proteasome Activity in Peripheral Blood Mononuclear Cells as an Indicator of Susceptibility to Bortezomib-Induced Severe Neurological Adverse Events in Patients with Multiple Myeloma. Measurement of Proteasome Activity in Peripheral Blood Mononuclear Cells as an Indicator of Susceptibility to Bortezomib-Induced Severe Neurological Adverse Events in Patients with Multiple Myeloma. Acta Haematol., 134, 1, 25-31 Acta Haematol., 134, 1, 25-31 Acta Haematol., 134, 1, 25-31 2015 Refereed English Research paper(scientific journal) Disclose to all
Sasaki K, Bean A, Shah S, Schutten E, Huseby PG, Peters B, Shen ZT, Vanguri V, Liggitt D, Huseby ES. Sasaki K, Bean A, Shah S, Schutten E, Huseby PG, Peters B, Shen ZT, Vanguri V, Liggitt D, Huseby ES. Sasaki K, Bean A, Shah S, Schutten E, Huseby PG, Peters B, Shen ZT, Vanguri V, Liggitt D, Huseby ES. Relapsing-remitting central nervous system autoimmunity mediated by GFAP-specific CD8 T cells. Relapsing-remitting central nervous system autoimmunity mediated by GFAP-specific CD8 T cells. Relapsing-remitting central nervous system autoimmunity mediated by GFAP-specific CD8 T cells. J Immunol., 192, 7, 3029-3042 J Immunol., 192, 7, 3029-3042 J Immunol., 192, 7, 3029-3042 2014/04 Refereed English Research paper(scientific journal) Disclose to all
Florea BI, Verdoes M, Li N, van der Linden WA, Geurink PP, van den Elst H, Hofmann T, de Ru A, van Veelen PA, Tanaka K, Sasaki K, Murata S, den Dulk H, Brouwer J, Ossendorp FA, Kisselev AF, Overkleeft HS. Florea BI, Verdoes M, Li N, van der Linden WA, Geurink PP, van den Elst H, Hofmann T, de Ru A, van Veelen PA, Tanaka K, Sasaki K, Murata S, den Dulk H, Brouwer J, Ossendorp FA, Kisselev AF, Overkleeft HS. Florea BI, Verdoes M, Li N, van der Linden WA, Geurink PP, van den Elst H, Hofmann T, de Ru A, van Veelen PA, Tanaka K, Sasaki K, Murata S, den Dulk H, Brouwer J, Ossendorp FA, Kisselev AF, Overkleeft HS. Activity-based profiling reveals reactivity of the murine thymoproteasome-specific subunit beta5t. Activity-based profiling reveals reactivity of the murine thymoproteasome-specific subunit beta5t. Activity-based profiling reveals reactivity of the murine thymoproteasome-specific subunit beta5t. Chem Biol., 17, 8, 795-801 Chem Biol., 17, 8, 795-801 Chem Biol., 17, 8, 795-801 2010/08 Refereed English Research paper(scientific journal) Disclose to all
Sasaki K, Hamazaki J, Koike M, Hirano Y, Komatsu M, Uchiyama Y, Tanaka K, Murata S. Sasaki K, Hamazaki J, Koike M, Hirano Y, Komatsu M, Uchiyama Y, Tanaka K, Murata S. Sasaki K, Hamazaki J, Koike M, Hirano Y, Komatsu M, Uchiyama Y, Tanaka K, Murata S. PAC1 gene knockout reveals an essential role of chaperone-mediated 20S proteasome biogenesis and latent 20S proteasomes in cellular homeostasis. PAC1 gene knockout reveals an essential role of chaperone-mediated 20S proteasome biogenesis and latent 20S proteasomes in cellular homeostasis. PAC1 gene knockout reveals an essential role of chaperone-mediated 20S proteasome biogenesis and latent 20S proteasomes in cellular homeostasis. Mol Cell Biol., 30, 15, 3864-3874 Mol Cell Biol., 30, 15, 3864-3874 Mol Cell Biol., 30, 15, 3864-3874 2010/08 Refereed English Research paper(scientific journal) Disclose to all
Nitta T, Murata S, Sasaki K, Fujii H, Ripen AM, Ishimaru N, Koyasu S, Tanaka K, Takahama Y. Nitta T, Murata S, Sasaki K, Fujii H, Ripen AM, Ishimaru N, Koyasu S, Tanaka K, Takahama Y. Nitta T, Murata S, Sasaki K, Fujii H, Ripen AM, Ishimaru N, Koyasu S, Tanaka K, Takahama Y. Thymoproteasome shapes immunocompetent repertoire of CD8+ T cells. Thymoproteasome shapes immunocompetent repertoire of CD8+ T cells. Thymoproteasome shapes immunocompetent repertoire of CD8+ T cells. Immunity., 32, 1, 29-40 Immunity., 32, 1, 29-40 Immunity., 32, 1, 29-40 2010/01 Refereed English Research paper(scientific journal) Disclose to all
Kaneko T, Hamazaki J, Iemura S, Sasaki K, Furuyama K, Natsume T, Tanaka K, Murata S. Kaneko T, Hamazaki J, Iemura S, Sasaki K, Furuyama K, Natsume T, Tanaka K, Murata S. Kaneko T, Hamazaki J, Iemura S, Sasaki K, Furuyama K, Natsume T, Tanaka K, Murata S. Assembly pathway of the Mammalian proteasome base subcomplex is mediated by multiple specific chaperones. Assembly pathway of the Mammalian proteasome base subcomplex is mediated by multiple specific chaperones. Assembly pathway of the Mammalian proteasome base subcomplex is mediated by multiple specific chaperones. Cell, 137, 5, 914-925 Cell, 137, 5, 914-925 Cell, 137, 5, 914-925 2009/05 Refereed English Research paper(scientific journal) Disclose to all
Hamazaki J, Sasaki K, Kawahara H, Hisanaga S, Tanaka K, Murata S. Hamazaki J, Sasaki K, Kawahara H, Hisanaga S, Tanaka K, Murata S. Hamazaki J, Sasaki K, Kawahara H, Hisanaga S, Tanaka K, Murata S. Rpn10-mediated degradation of ubiquitinated proteins is essential for mouse development. Rpn10-mediated degradation of ubiquitinated proteins is essential for mouse development. Rpn10-mediated degradation of ubiquitinated proteins is essential for mouse development. Mol Cell Biol., 27, 19, 6629-6638 Mol Cell Biol., 27, 19, 6629-6638 Mol Cell Biol., 27, 19, 6629-6638 2007/10 Refereed English Research paper(scientific journal) Disclose to all
Murata S, Sasaki K, Kishimoto T, Niwa S, Hayashi H, Takahama Y, Tanaka K. Murata S, Sasaki K, Kishimoto T, Niwa S, Hayashi H, Takahama Y, Tanaka K. Murata S, Sasaki K, Kishimoto T, Niwa S, Hayashi H, Takahama Y, Tanaka K. Regulation of CD8+ T cell development by thymus-specific proteasomes. Regulation of CD8+ T cell development by thymus-specific proteasomes. Regulation of CD8+ T cell development by thymus-specific proteasomes. Science, 316, 5829, 1349-1353 Science, 316, 5829, 1349-1353 Science, 316, 5829, 1349-1353 2007/06 Refereed English Research paper(scientific journal) Disclose to all

  • <<
  • >>
Title language:
Conference Activities & Talks
Title Title(Japanese) Title(English) Conference Conference(Japanese) Conference(English) Promotor Promotor(Japanese) Promotor(English) Date Language Assortment Disclose
An autoinflammatory mechanism by TNFa-expressing T cells An autoinflammatory mechanism by TNFa-expressing T cells An autoinflammatory mechanism by TNFa-expressing T cells 17th TNF conference 2019 17th TNF conference 2019 17th TNF conference 2019 2019/06/05 English Poster presentation Disclose to all
LUBACによる炎症制御機構 LUBACによる炎症制御機構 第一回ユビキチン研究会 第一回ユビキチン研究会 2018/01 Japanese Oral presentation(general) Disclose to all
LUBAC-mediated immune maintenance for tissue homeostasis 直鎖状ユビキチン鎖生成酵素LUBACによる免疫恒常性維持と炎症制御 LUBAC-mediated immune maintenance for tissue homeostasis ConBio2017 ConBio2017 ConBio2017 2017/12/09 Japanese Symposium workshop panel(nominated) Disclose to all
LUBAC deficiency of regulatory T cells induces autoinflammaory-like pathology as an alternative autoimmune manifestation LUBAC deficiency of regulatory T cells induces autoinflammaory-like pathology as an alternative autoimmune manifestation LUBAC deficiency of regulatory T cells induces autoinflammaory-like pathology as an alternative autoimmune manifestation The 45th Annual Meeting of The Japanese Society for Immunology The 45th Annual Meeting of The Japanese Society for Immunology The 45th Annual Meeting of The Japanese Society for Immunology 2016/12 English Poster presentation Disclose to all
SHARPIN欠損マウスにおける免疫恒常性の破綻 SHARPIN欠損マウスにおける免疫恒常性の破綻 第8回シグナルネットワーク研究会 第8回シグナルネットワーク研究会 2016/05/27 Japanese Oral presentation(general) Disclose to all
A loss of anti-inflammatory T cells in cpdm mice A loss of anti-inflammatory T cells in cpdm mice A loss of anti-inflammatory T cells in cpdm mice The 44th Annual Meeting of The Japanese Society for Immunology The 44th Annual Meeting of The Japanese Society for Immunology The 44th Annual Meeting of The Japanese Society for Immunology 2015/11 English Oral presentation(general) Disclose to all
• Regulation of intrathymic peptide production by the thymus-specific proteasome subunit β5t. • Regulation of intrathymic peptide production by the thymus-specific proteasome subunit β5t. • Regulation of intrathymic peptide production by the thymus-specific proteasome subunit β5t. 1st Conference on Proteomics of Protein Degradation & Ubiquitin Pathways. 1st Conference on Proteomics of Protein Degradation & Ubiquitin Pathways. 1st Conference on Proteomics of Protein Degradation & Ubiquitin Pathways. 2010 English Oral presentation(general) Disclose to all
• Genetic analysis of proteasome assembling chaperone 1 in mice • Genetic analysis of proteasome assembling chaperone 1 in mice • Genetic analysis of proteasome assembling chaperone 1 in mice Zomes V Zomes V Zomes V 2008 English Poster presentation Disclose to all
Title language:
Books etc
Author Author(Japanese) Author(English) Title Title(Japanese) Title(English) Publisher Publisher(Japanese) Publisher(English) Publication date Language Type Disclose
佐々木 克博 佐々木 克博 医学のあゆみ 医学のあゆみ 医歯薬出版 医歯薬出版 2018/12 Contributor Disclose to all
Title language:
External funds: competitive funds and Grants-in-Aid for Scientific Research (Kakenhi)
Type Position Title(Japanese) Title(English) Period
科研費 Representative ネクロプトーシス誘導を介したT細胞依存性自己炎症病態機構の解明 2018/04/01-2020/03/31
科研費 Representative LUBAC欠損型自己炎症性疾患における抗炎症性T細胞の同定と機能解析 2016/04/01-2018/03/31
External funds: other than those above
System Main person Title(Japanese) Title(English) Period
特別研究員奨励費(PD) 佐々木克博 胸腺特異的タンパク質分解メカニズムによる免疫制御機構の解明 2011/04/01-2013/09/31
特別研究員奨励費(DC1) 佐々木克博 胸腺プロテアソームによる免疫制御機構の解明 2008/04/01-2010/03/31
Faculty management (title, position)
Title Period
動物実験委員会 2018/04/01-2018/09/30