中野 雅博

Last Update: 2019/09/24 12:59:31

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Name(Kanji/Kana/Abecedarium Latinum)
中野 雅博/ナカノ マサヒロ/Nakano, Masahiro
Primary Affiliation(Org1/Job title)
Institute for Frontier Life and Medical Sciences/Assistant Professor
Affiliated programs (koza)
Org1 Job title
Graduate Schools Biostudies Assistant Professor
Academic Degree
Field(Japanese) Field(English) University(Japanese) University(English) Method
修士(農学) 九州大学
博士(農学) 九州大学
researchmap URL
https://researchmap.jp/7000015496
Research Topics
(Japanese)
インフルエンザウイルスのゲノム転写・複製機構の解明
Overview of the research
(Japanese)
インフルエンザウイルスのゲノムRNAは、核タンパク質NPやポリメラーゼとともにvRNPを形成する。vRNPはmRNA合成(転写)およびcRNA合成(複製の第一段階)を担う。ウイルス粒子から精製したvRNPは、柔軟な二重らせん構造を持つことが近年の電子顕微鏡解析より明らかとなっている。しかし、mRNAあるいはcRNA合成中のvRNPの構造については全く解明されておらず、また、これらのRNAがどのようにして合成されるのかも分かっていない。そこで私は、高速原子間力顕微鏡(AFM)を用いて機能的な状態のvRNPを解析することによって、微細構造学的観点からインフルエンザウイルスのゲノム転写・複製機構を明らかにすることを目的として研究を行っている。
Fields of research (key words)
Key words(Japanese) Key words(English)
ウイルス学
分子生物学
Published Papers
Author Author(Japanese) Author(English) Title Title(Japanese) Title(English) Bibliography Bibliography(Japanese) Bibliography(English) Publication date Refereed paper Language Publishing type Disclose
Yamagata Y, Muramoto Y, Miyamoto S, Shindo K, Nakano M, Noda T Yamagata Y, Muramoto Y, Miyamoto S, Shindo K, Nakano M, Noda T Yamagata Y, Muramoto Y, Miyamoto S, Shindo K, Nakano M, Noda T Generation of a purely clonal defective interfering influenza virus. Generation of a purely clonal defective interfering influenza virus. Generation of a purely clonal defective interfering influenza virus. Microbiology and immunology, 63, 5, 164-171 Microbiology and immunology, 63, 5, 164-171 Microbiology and immunology, 63, 5, 164-171 2019/05 Refereed Disclose to all
Shimada T, Yamamoto K, Nakano M, Watanabe H, Schleheck D, Ishihama A Shimada T, Yamamoto K, Nakano M, Watanabe H, Schleheck D, Ishihama A Shimada T, Yamamoto K, Nakano M, Watanabe H, Schleheck D, Ishihama A Regulatory role of CsqR (YihW) in transcription of the genes for catabolism of the anionic sugar sulfoquinovose (SQ) in Escherichia coli K-12. Regulatory role of CsqR (YihW) in transcription of the genes for catabolism of the anionic sugar sulfoquinovose (SQ) in Escherichia coli K-12. Regulatory role of CsqR (YihW) in transcription of the genes for catabolism of the anionic sugar sulfoquinovose (SQ) in Escherichia coli K-12. Microbiology (Reading, England), 165, 1, 78-89 Microbiology (Reading, England), 165, 1, 78-89 Microbiology (Reading, England), 165, 1, 78-89 2019/01 Refereed Disclose to all
Hatakeyama D, Shoji M, Yamayoshi S, Yoh R, Ohmi N, Takenaka S, Saitoh A, Arakaki Y, Masuda A, Komatsu T, Nagano R, Nakano M, Noda T, Kawaoka Y, Kuzuhara T Hatakeyama D, Shoji M, Yamayoshi S, Yoh R, Ohmi N, Takenaka S, Saitoh A, Arakaki Y, Masuda A, Komatsu T, Nagano R, Nakano M, Noda T, Kawaoka Y, Kuzuhara T Hatakeyama D, Shoji M, Yamayoshi S, Yoh R, Ohmi N, Takenaka S, Saitoh A, Arakaki Y, Masuda A, Komatsu T, Nagano R, Nakano M, Noda T, Kawaoka Y, Kuzuhara T Influenza A virus nucleoprotein is acetylated by histone acetyltransferases PCAF and GCN5. Influenza A virus nucleoprotein is acetylated by histone acetyltransferases PCAF and GCN5. Influenza A virus nucleoprotein is acetylated by histone acetyltransferases PCAF and GCN5. The Journal of biological chemistry, 293, 19, 7126-7138 The Journal of biological chemistry, 293, 19, 7126-7138 The Journal of biological chemistry, 293, 19, 7126-7138 2018/05 Refereed Disclose to all
Sugino H, Usui T, Shimada T, Nakano M, Ogasawara H, Ishihama A, Hirata A Sugino H, Usui T, Shimada T, Nakano M, Ogasawara H, Ishihama A, Hirata A Sugino H, Usui T, Shimada T, Nakano M, Ogasawara H, Ishihama A, Hirata A A structural sketch of RcdA, a transcription factor controlling the master regulator of biofilm formation. A structural sketch of RcdA, a transcription factor controlling the master regulator of biofilm formation. A structural sketch of RcdA, a transcription factor controlling the master regulator of biofilm formation. FEBS letters FEBS letters FEBS letters 2017/06 Refereed Disclose to all
Takada H, Shimada T, Dey D, Quyyum MZ, Nakano M, Ishiguro A, Yoshida H, Yamamoto K, Sen R, Ishihama A Takada H, Shimada T, Dey D, Quyyum MZ, Nakano M, Ishiguro A, Yoshida H, Yamamoto K, Sen R, Ishihama A Takada H, Shimada T, Dey D, Quyyum MZ, Nakano M, Ishiguro A, Yoshida H, Yamamoto K, Sen R, Ishihama A Differential Regulation of rRNA and tRNA Transcription from the rRNA-tRNA Composite Operon in Escherichia coli. Differential Regulation of rRNA and tRNA Transcription from the rRNA-tRNA Composite Operon in Escherichia coli. Differential Regulation of rRNA and tRNA Transcription from the rRNA-tRNA Composite Operon in Escherichia coli. PloS one, 11, 12, e0163057 PloS one, 11, 12, e0163057 PloS one, 11, 12, e0163057 2016 Refereed Disclose to all
Nakano M, Kamino K Nakano M, Kamino K Nakano M, Kamino K Amyloid-like conformation and interaction for the self-assembly in barnacle underwater cement. Amyloid-like conformation and interaction for the self-assembly in barnacle underwater cement. Amyloid-like conformation and interaction for the self-assembly in barnacle underwater cement. Biochemistry, 54, 3, 826-835 Biochemistry, 54, 3, 826-835 Biochemistry, 54, 3, 826-835 2015/01 Refereed Disclose to all
Yamamoto K, Nakano M, Ishihama A Yamamoto K, Nakano M, Ishihama A Yamamoto K, Nakano M, Ishihama A Regulatory role of transcription factor SutR (YdcN) in sulfur utilization in Escherichia coli. Regulatory role of transcription factor SutR (YdcN) in sulfur utilization in Escherichia coli. Regulatory role of transcription factor SutR (YdcN) in sulfur utilization in Escherichia coli. Microbiology (Reading, England), 161, Pt 1, 99-111 Microbiology (Reading, England), 161, Pt 1, 99-111 Microbiology (Reading, England), 161, Pt 1, 99-111 2015/01 Refereed Disclose to all
Hatakeyama D, Shoji M, Yamayoshi S, Hirota T, Nagae M, Yanagisawa S, Nakano M, Ohmi N, Noda T, Kawaoka Y, Kuzuhara T Hatakeyama D, Shoji M, Yamayoshi S, Hirota T, Nagae M, Yanagisawa S, Nakano M, Ohmi N, Noda T, Kawaoka Y, Kuzuhara T Hatakeyama D, Shoji M, Yamayoshi S, Hirota T, Nagae M, Yanagisawa S, Nakano M, Ohmi N, Noda T, Kawaoka Y, Kuzuhara T A novel functional site in the PB2 subunit of influenza A virus essential for acetyl-CoA interaction, RNA polymerase activity, and viral replication. A novel functional site in the PB2 subunit of influenza A virus essential for acetyl-CoA interaction, RNA polymerase activity, and viral replication. A novel functional site in the PB2 subunit of influenza A virus essential for acetyl-CoA interaction, RNA polymerase activity, and viral replication. The Journal of biological chemistry, 289, 36, 24980-24994 The Journal of biological chemistry, 289, 36, 24980-24994 The Journal of biological chemistry, 289, 36, 24980-24994 2014/09 Refereed Disclose to all
Nakano M, Ogasawara H, Shimada T, Yamamoto K, Ishihama A Nakano M, Ogasawara H, Shimada T, Yamamoto K, Ishihama A Nakano M, Ogasawara H, Shimada T, Yamamoto K, Ishihama A Involvement of cAMP-CRP in transcription activation and repression of the pck gene encoding PEP carboxykinase, the key enzyme of gluconeogenesis. Involvement of cAMP-CRP in transcription activation and repression of the pck gene encoding PEP carboxykinase, the key enzyme of gluconeogenesis. Involvement of cAMP-CRP in transcription activation and repression of the pck gene encoding PEP carboxykinase, the key enzyme of gluconeogenesis. FEMS microbiology letters, 355, 2, 93-99 FEMS microbiology letters, 355, 2, 93-99 FEMS microbiology letters, 355, 2, 93-99 2014/06 Refereed Disclose to all
Shimada T, Katayama Y, Kawakita S, Ogasawara H, Nakano M, Yamamoto K, Ishihama A Shimada T, Katayama Y, Kawakita S, Ogasawara H, Nakano M, Yamamoto K, Ishihama A Shimada T, Katayama Y, Kawakita S, Ogasawara H, Nakano M, Yamamoto K, Ishihama A A novel regulator RcdA of the csgD gene encoding the master regulator of biofilm formation in Escherichia coli. A novel regulator RcdA of the csgD gene encoding the master regulator of biofilm formation in Escherichia coli. A novel regulator RcdA of the csgD gene encoding the master regulator of biofilm formation in Escherichia coli. MicrobiologyOpen, 1, 4, 381-394 MicrobiologyOpen, 1, 4, 381-394 MicrobiologyOpen, 1, 4, 381-394 2012/12 Refereed Disclose to all
Kamino K, Nakano M, Kanai S Kamino K, Nakano M, Kanai S Kamino K, Nakano M, Kanai S Significance of the conformation of building blocks in curing of barnacle underwater adhesive. Significance of the conformation of building blocks in curing of barnacle underwater adhesive. Significance of the conformation of building blocks in curing of barnacle underwater adhesive. The FEBS journal, 279, 10, 1750-1760 The FEBS journal, 279, 10, 1750-1760 The FEBS journal, 279, 10, 1750-1760 2012/05 Refereed Disclose to all

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Conference Activities & Talks
Title Title(Japanese) Title(English) Conference Conference(Japanese) Conference(English) Promotor Promotor(Japanese) Promotor(English) Date Language Assortment Disclose
Ultrastructure of the influenza virus ribonucleoprotein complexes producing viral RNAs Ultrastructure of the influenza virus ribonucleoprotein complexes producing viral RNAs Ultrastructure of the influenza virus ribonucleoprotein complexes producing viral RNAs 17th NSV 2018 17th NSV 2018 17th NSV 2018 2018/06 English Oral presentation(general) Disclose to all
AFM analysis of dsRNA binding mechanism of influenza A virus NS1 原子間力顕微鏡を用いたA型インフルエンザウイルスNS1の二本鎖RNAに対する結合機構の解析 AFM analysis of dsRNA binding mechanism of influenza A virus NS1 7th Negative Strand Virus-Japan Symposium 7th Negative Strand Virus-Japan Symposium 7th Negative Strand Virus-Japan Symposium 2018/01 Japanese Oral presentation(general) Disclose to all
Ultrastructural analysis of RNA synthesized by influenza virus vRNP インフルエンザウイルスRNPが合成するRNAの微細構造解析 Ultrastructural analysis of RNA synthesized by influenza virus vRNP RNAフロンティアミーティング2017 RNAフロンティアミーティング2017 2017/11 Japanese Oral presentation(general) Disclose to all
The mechanism of genome transcription and replication of influenza virus analyzed by high-speed atomic force microscopy 高速原子間力顕微鏡を用いたインフルエンザウイルスのゲノム転写・複製機構の解明 The mechanism of genome transcription and replication of influenza virus analyzed by high-speed atomic force microscopy 6th Negative Strand Virus-Japan Symposium 6th Negative Strand Virus-Japan Symposium 6th Negative Strand Virus-Japan Symposium 2017/01 Japanese Oral presentation(general) Disclose to all
Ultrastructural analysis of the influenza virus vRNP during transcription 転写中インフルエンザウイルスRNPの微細構造解析 Ultrastructural analysis of the influenza virus vRNP during transcription 5th Negative Strand Virus-Japan Symposium 5th Negative Strand Virus-Japan Symposium 5th Negative Strand Virus-Japan Symposium 2016/01 Japanese Oral presentation(general) Disclose to all
Analysis of influenza virus transcription using high-speed atomic force microscopy 高速原子間力顕微鏡を用いたインフルエンザウイルス転写機構の解析 Analysis of influenza virus transcription using high-speed atomic force microscopy 第29回 インフルエンザ研究者交流の会シンポジウム 第29回 インフルエンザ研究者交流の会シンポジウム 2015/05 Japanese Oral presentation(general) Disclose to all
Title language:
External funds: competitive funds and Grants-in-Aid for Scientific Research (Kakenhi)
Type Position Title(Japanese) Title(English) Period
基板研究(C) Representative 高速原子間力顕微鏡を用いたウイルス転写複合体の微細構造解析 2016/04/01-2019/03/31
基盤研究(C) Representative 高速原子間力顕微鏡を用いたウイルス転写複合体の微細構造解析 (平成28年度分) 2016/04/01-2017/03/31
基盤研究(C) Representative 高速原子間力顕微鏡を用いたウイルス転写複合体の微細構造解析 (平成29年度分) 2017/04/01-2018/03/31
基盤研究(C) Representative 高速原子間力顕微鏡を用いたウイルス転写複合体の微細構造解析 (平成30年度分) 2018/04/01-2019/03/31
Faculty management (title, position)
Title Period
共同利用機器等委員会 2016/04/01-2017/03/31
化学物質管理委員会 委員 2016/04/01-2017/03/31
(旧ウイルス研)共同利用機器等委員会 委員 2016/10/01-
化学物質管理委員会 委員 2016/10/01-
共同利用機器等委員会 2018/04/01-2020/03/31