藤田 芳久

Last Update: 2019/07/05 17:46:37

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Name(Kanji/Kana/Abecedarium Latinum)
藤田 芳久/フジタ ヨシヒサ/Fujita, Yoshihisa
Primary Affiliation(Org1/Job title)
Kyoto University Hospital/医員(研修医)
Academic Degree
Field(Japanese) Field(English) University(Japanese) University(English) Method
博士(医学) 京都大学
researchmap URL
https://researchmap.jp/yoshihisa_fujita
Research Topics
(Japanese)
生命現象の計算モデリング
Overview of the research
(Japanese)
複雑な生命現象の背後にあるメカニズムを数理的手法を用いて理解することを目指す。計算モデル構築、シミュレーションおよび大規模実験データの解析を駆使して研究を行う。
Fields of research (key words)
Key words(Japanese) Key words(English)
システム生物学 Systems biology
計算論的神経科学 Computational neuroscience
Published Papers
Author Author(Japanese) Author(English) Title Title(Japanese) Title(English) Bibliography Bibliography(Japanese) Bibliography(English) Publication date Refereed paper Language Publishing type Disclose
Muta Y, Fujita Y, Sumiyama K, Sakurai A, Taketo MM, Chiba T, Seno H, Aoki K, Matsuda M, Imajo M Muta Y, Fujita Y, Sumiyama K, Sakurai A, Taketo MM, Chiba T, Seno H, Aoki K, Matsuda M, Imajo M Muta Y, Fujita Y, Sumiyama K, Sakurai A, Taketo MM, Chiba T, Seno H, Aoki K, Matsuda M, Imajo M Composite regulation of ERK activity dynamics underlying tumour-specific traits in the intestine. Composite regulation of ERK activity dynamics underlying tumour-specific traits in the intestine. Composite regulation of ERK activity dynamics underlying tumour-specific traits in the intestine. Nature communications, 9, 1, 2174 Nature communications, 9, 1, 2174 Nature communications, 9, 1, 2174 2018/06 Refereed Disclose to all
Hiratsuka T, Fujita Y, Naoki H, Aoki K, Kamioka Y, Matsuda M Hiratsuka T, Fujita Y, Naoki H, Aoki K, Kamioka Y, Matsuda M Hiratsuka T, Fujita Y, Naoki H, Aoki K, Kamioka Y, Matsuda M Intercellular propagation of extracellular signal-regulated kinase activation revealed by in vivo imaging of mouse skin. Intercellular propagation of extracellular signal-regulated kinase activation revealed by in vivo imaging of mouse skin. Intercellular propagation of extracellular signal-regulated kinase activation revealed by in vivo imaging of mouse skin. eLife, 4, e05178 eLife, 4, e05178 eLife, 4, e05178 2015/02 Refereed Disclose to all
Komatsu N, Fujita Y, Matsuda M, Aoki K Komatsu N, Fujita Y, Matsuda M, Aoki K Komatsu N, Fujita Y, Matsuda M, Aoki K mTORC1 upregulation via ERK-dependent gene expression change confers intrinsic resistance to MEK inhibitors in oncogenic KRas-mutant cancer cells. mTORC1 upregulation via ERK-dependent gene expression change confers intrinsic resistance to MEK inhibitors in oncogenic KRas-mutant cancer cells. mTORC1 upregulation via ERK-dependent gene expression change confers intrinsic resistance to MEK inhibitors in oncogenic KRas-mutant cancer cells. Oncogene Oncogene Oncogene 2015/02 Refereed Disclose to all
Fujita Y, Komatsu N, Matsuda M, Aoki K Fujita Y, Komatsu N, Matsuda M, Aoki K Fujita Y, Komatsu N, Matsuda M, Aoki K Fluorescence resonance energy transfer based quantitative analysis of feedforward and feedback loops in epidermal growth factor receptor signaling and the sensitivity to molecular targeting drugs. Fluorescence resonance energy transfer based quantitative analysis of feedforward and feedback loops in epidermal growth factor receptor signaling and the sensitivity to molecular targeting drugs. Fluorescence resonance energy transfer based quantitative analysis of feedforward and feedback loops in epidermal growth factor receptor signaling and the sensitivity to molecular targeting drugs. The FEBS journal, 281, 14, 3177-3192 The FEBS journal, 281, 14, 3177-3192 The FEBS journal, 281, 14, 3177-3192 2014/07 Refereed Disclose to all
Aoki K, Kumagai Y, Sakurai A, Komatsu N, Fujita Y, Shionyu C, Matsuda M Aoki K, Kumagai Y, Sakurai A, Komatsu N, Fujita Y, Shionyu C, Matsuda M Aoki K, Kumagai Y, Sakurai A, Komatsu N, Fujita Y, Shionyu C, Matsuda M Stochastic ERK activation induced by noise and cell-to-cell propagation regulates cell density-dependent proliferation. Stochastic ERK activation induced by noise and cell-to-cell propagation regulates cell density-dependent proliferation. Stochastic ERK activation induced by noise and cell-to-cell propagation regulates cell density-dependent proliferation. Molecular cell, 52, 4, 529-540 Molecular cell, 52, 4, 529-540 Molecular cell, 52, 4, 529-540 2013/11 Refereed Disclose to all
Komatsu N, Aoki K, Yamada M, Yukinaga H, Fujita Y, Kamioka Y, Matsuda M Komatsu N, Aoki K, Yamada M, Yukinaga H, Fujita Y, Kamioka Y, Matsuda M Komatsu N, Aoki K, Yamada M, Yukinaga H, Fujita Y, Kamioka Y, Matsuda M Development of an optimized backbone of FRET biosensors for kinases and GTPases. Development of an optimized backbone of FRET biosensors for kinases and GTPases. Development of an optimized backbone of FRET biosensors for kinases and GTPases. Molecular biology of the cell, 22, 23, 4647-4656 Molecular biology of the cell, 22, 23, 4647-4656 Molecular biology of the cell, 22, 23, 4647-4656 2011/12 Refereed Disclose to all
Kamioka Y, Yasuda S, Fujita Y, Aoki K, Matsuda M Kamioka Y, Yasuda S, Fujita Y, Aoki K, Matsuda M Kamioka Y, Yasuda S, Fujita Y, Aoki K, Matsuda M Multiple decisive phosphorylation sites for the negative feedback regulation of SOS1 via ERK. Multiple decisive phosphorylation sites for the negative feedback regulation of SOS1 via ERK. Multiple decisive phosphorylation sites for the negative feedback regulation of SOS1 via ERK. The Journal of biological chemistry, 285, 43, 33540-33548 The Journal of biological chemistry, 285, 43, 33540-33548 The Journal of biological chemistry, 285, 43, 33540-33548 2010/10 Refereed Disclose to all
Matsunaga-Udagawa R, Fujita Y, Yoshiki S, Terai K, Kamioka Y, Kiyokawa E, Yugi K, Aoki K, Matsuda M Matsunaga-Udagawa R, Fujita Y, Yoshiki S, Terai K, Kamioka Y, Kiyokawa E, Yugi K, Aoki K, Matsuda M Matsunaga-Udagawa R, Fujita Y, Yoshiki S, Terai K, Kamioka Y, Kiyokawa E, Yugi K, Aoki K, Matsuda M The scaffold protein Shoc2/SUR-8 accelerates the interaction of Ras and Raf. The scaffold protein Shoc2/SUR-8 accelerates the interaction of Ras and Raf. The scaffold protein Shoc2/SUR-8 accelerates the interaction of Ras and Raf. The Journal of biological chemistry, 285, 10, 7818-7826 The Journal of biological chemistry, 285, 10, 7818-7826 The Journal of biological chemistry, 285, 10, 7818-7826 2010/03 Refereed Disclose to all
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