岩井 一宏

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Name(Kanji/Kana/Abecedarium Latinum)
岩井 一宏/イワイ カズヒロ/Iwai, Kazuhiro
Primary Affiliation(Org1/Job title)
Graduate Schools Medicine/Professor
Faculty
Org1 Job title
医学部
Contact Address
Type Address(Japanese) Address(English)
Office 〒606-8501 京都市左京区吉田近衛町 Department of Molecular and Cellular Physiology, Graduate School of Medicine, Kyoto University Yoshida-konoe-cho, Sakyo-ku, Kyoto 606-8501, Japan
Phone
Type Number
Office 075-753-4671
E-mail Address
E-mail address
kiwai @ mcp.med.kyoto-u.ac.jp
Academic Organizations You are Affiliated to in Japan
Organization name(Japanese) Organization name(English)
日本生化学会 The Japanese Biochemical Society
日本分子生物学会 The Molecular Biology Society of Japan
日本癌学会 Japanese Cancer Association
日本細胞生物学会 Japan Society of Cell Biology
日本鉄バイオサイエンス学会 The Japan Bio Iron Society
日本病態プロテアーゼ学会 Japan Society for Proteases in Pathophysiology
Academic Organizations Overaseas You are Affiliated to
Organization name Country
The American Society for Biochemistry and Molecular Biology 米国
American Society for Microbiology 米国
The American Association of Immunologists 米国
Academic Degree
Field(Japanese) Field(English) University(Japanese) University(English) Method
博士(医学) Doctor of Medical Science (equivalent to Ph. D) 京都大学 Kyoto University
Graduate School
University(Japanese) University(English) Faculty(Japanese) Faculty(English) Major(Japanese) Major(English) Degree
京都大学 Kyoto University 大学院医学研究科博士課程内科系専攻 Graduate School of Medicine Internal Medicine 研究指導認定退学
京都大学 Kyoto University 大学院医学研究科博士課程内科系専攻 Graduate School of Medicine Internal Medicine 修了
Undergraduate School / Major(s)
University(Japanese) University(English) Faculty(Japanese) Faculty(English) Major(s)(Japanese) Major(s)(English) Degree
京都大学 Kyoto University 医学部医学科 Faculty of Medicine 卒業
京都大学 Kyoto University 医学部医学進学課程 修了
Work Experience
Period Organization(Japanese) Organization(English) Job title(Japanese) Job title(English)
1985/06/01-1987/03/31 神戸市立中央市民病院 Kobe General Hospital, Kobe, Japan 内科研修医 Resident physician
1992/10/1-1993/03/31 京都大学医学部 Faculty of Medicine, Kyoto University, Kyoto, Japan 助手 Instructor
1993/04/01-1996/03/28 米国国立保健研究所 National Institute of Child Health and Human Development, National Institutes of Health, USA 研究員 Visiting Fellow
1996/03/29-1997/05/31 京都大学大学院医学研究科 Graduate School of Medicine, Kyoto University, Japan 助手 Assistant Professor
1997/06/01-1999/03/31 京都大学大学院医学研究科 Graduate School of Medicine, Kyoto University, Japan 助教授 Associate Professor
1999/04/01-2001/06/30 京都大学大学院生命科学研究科 Graduate School of Biostudies, Kyoto University, Japan 助教授 Associate Professor
2001/07/01-2008/03/31 大阪市立大学大学院医学研究科 Graduate School of Medicine, Osaka City University, Japan 教授 Professor
2008/04/01-2012/03/31 大阪大学大学院生命機能研究科/医学系研究科 Graduate School of Frontier Biosciences and Graduate School of Medicine, Osaka University, Japan 教授 Professor
2012/04/01- 京都大学大学院医学研究科 Graduate School of Medicine, Kyoto University, Japan 教授 Professor
Language of Instruction
Language(japanese) Language(english) Code
英語 English eng
Personal Website(s) (URL(s))
URL
http://www.mcp-kyoto-u.jp
ORCID ID
https://orcid.org/0000-0001-5620-5951
researchmap URL
https://researchmap.jp/Kazuhiro_Iwai
Research Topics
(Japanese)
ユビキチン修飾系による生体制御機構 ユビキチン系の破綻による炎症性疾患、がんの発症機構 ユビキチン修飾系によるNF-kappaB活性化、細胞死抑制機構 鉄代謝調節機構
(English)
ubiquitin conjugation system Involvement of the ubiquitin system in the pathogenesis of inflammatory diseases and cancer Roles of the ubiquitin system played in NF-kappaB activation and cell death protection Iron metabolism
Fields of research (key words)
Key words(Japanese) Key words(English)
ユビキチン ubiquitin
NF-kappaB NF-kappaB
鉄代謝 iron metabolism
直鎖状ポリユビキチン鎖 linear polyubiquitination
細胞死抑制 Cell death protection
Published Papers
Author Author(Japanese) Author(English) Title Title(Japanese) Title(English) Bibliography Bibliography(Japanese) Bibliography(English) Publication date Refereed paper Language Publishing type Disclose
Yasuhiro Fuseya, Hiroaki Fujita, Minsoo Kim, Fumiaki Ohtake, Akira Nishide, Katsuhiro Sasaki, Yasushi Saeki, Keiji Tanaka, Ryosuke Takahashi, Kazuhiro Iwai Yasuhiro Fuseya, Hiroaki Fujita, Minsoo Kim, Fumiaki Ohtake, Akira Nishide, Katsuhiro Sasaki, Yasushi Saeki, Keiji Tanaka, Ryosuke Takahashi, Kazuhiro Iwai Yasuhiro Fuseya, Hiroaki Fujita, Minsoo Kim, Fumiaki Ohtake, Akira Nishide, Katsuhiro Sasaki, Yasushi Saeki, Keiji Tanaka, Ryosuke Takahashi, Kazuhiro Iwai The HOIL-1L ligase modulates immune signalling and cell death via monoubiquitination of LUBAC The HOIL-1L ligase modulates immune signalling and cell death via monoubiquitination of LUBAC The HOIL-1L ligase modulates immune signalling and cell death via monoubiquitination of LUBAC Nature Cell Biology, 22, 6, 663-673 Nature Cell Biology, 22, 6, 663-673 Nature Cell Biology, 22, 6, 663-673 2020/06/11 Refereed Research paper(scientific journal) Disclose to all
Patricia L. Brazee, Luisa Morales-Nebreda, Natalia D. Magnani, Joe G.N. Garcia, Alexander V. Misharin, Karen M. Ridge, G.R. Scott Budinger, Kazuhiro Iwai, Laura A. Dada, Jacob I. Sznajder Patricia L. Brazee, Luisa Morales-Nebreda, Natalia D. Magnani, Joe G.N. Garcia, Alexander V. Misharin, Karen M. Ridge, G.R. Scott Budinger, Kazuhiro Iwai, Laura A. Dada, Jacob I. Sznajder Patricia L. Brazee, Luisa Morales-Nebreda, Natalia D. Magnani, Joe G.N. Garcia, Alexander V. Misharin, Karen M. Ridge, G.R. Scott Budinger, Kazuhiro Iwai, Laura A. Dada, Jacob I. Sznajder Linear ubiquitin assembly complex regulates lung epithelial–driven responses during influenza infection Linear ubiquitin assembly complex regulates lung epithelial–driven responses during influenza infection Linear ubiquitin assembly complex regulates lung epithelial–driven responses during influenza infection Journal of Clinical Investigation Journal of Clinical Investigation Journal of Clinical Investigation 2020/01/27 Refereed Research paper(scientific journal) Disclose to all
Katsuhiro Sasaki, Ai Himeno, Tomoko Nakagawa, Yoshiteru Sasaki, Hiroshi Kiyonari, Kazuhiro Iwai Katsuhiro Sasaki, Ai Himeno, Tomoko Nakagawa, Yoshiteru Sasaki, Hiroshi Kiyonari, Kazuhiro Iwai Katsuhiro Sasaki, Ai Himeno, Tomoko Nakagawa, Yoshiteru Sasaki, Hiroshi Kiyonari, Kazuhiro Iwai Modulation of autoimmune pathogenesis by T cell-triggered inflammatory cell death Modulation of autoimmune pathogenesis by T cell-triggered inflammatory cell death Modulation of autoimmune pathogenesis by T cell-triggered inflammatory cell death Nature Communications, 10, 1 Nature Communications, 10, 1 Nature Communications, 10, 1 2019/12 Refereed Research paper(scientific journal) Disclose to all
Yudai Nishitani, Hirotaka Okutani, Yukiko Takeda, Takeshi Uchida, Kazuhiro Iwai, Koichiro Ishimori Yudai Nishitani, Hirotaka Okutani, Yukiko Takeda, Takeshi Uchida, Kazuhiro Iwai, Koichiro Ishimori Yudai Nishitani, Hirotaka Okutani, Yukiko Takeda, Takeshi Uchida, Kazuhiro Iwai, Koichiro Ishimori Specific heme binding to heme regulatory motifs in iron regulatory proteins and its functional significance Specific heme binding to heme regulatory motifs in iron regulatory proteins and its functional significance Specific heme binding to heme regulatory motifs in iron regulatory proteins and its functional significance Journal of Inorganic Biochemistry, 198, 110726 Journal of Inorganic Biochemistry, 198, 110726 Journal of Inorganic Biochemistry, 198, 110726 2019/09 Refereed English Research paper(scientific journal) Disclose to all
Iwai K 岩井 一宏 Iwai K Regulation of cellular iron metabolism: Iron-dependent degradation of IRP by SCFFBXL5 ubiquitin ligase. Regulation of cellular iron metabolism: Iron-dependent degradation of IRP by SCFFBXL5 ubiquitin ligase. Regulation of cellular iron metabolism: Iron-dependent degradation of IRP by SCFFBXL5 ubiquitin ligase. Free Radic. Biol. Med., 133, 64-68 Free Radic. Biol. Med., 133, 64-68 Free Radic. Biol. Med., 133, 64-68 2019/03 Refereed English Research paper(scientific journal) Disclose to all
Wu, M, Chang, Y, Hu, H, Mu, R, Zhang, Y, Qin, X, Duan, X, Li, W, Tu, H, Zhang, W, Wang, G, Han, Q, Li, A, Zhou, T, Iwai, K, Zhang, X, Li, H Wu, M, Chang, Y, Hu, H, Mu, R, Zhang, Y, Qin, X, Duan, X, Li, W, Tu, H, Zhang, W, Wang, G, Han, Q, Li, A, Zhou, T, Iwai, K, Zhang, X, Li, H LUBAC controls chromosome alignment by targeting CENP-E to attached kinetochores. LUBAC controls chromosome alignment by targeting CENP-E to attached kinetochores. LUBAC controls chromosome alignment by targeting CENP-E to attached kinetochores. Nature Commun., 10, 1 Nature Commun., 10, 1 Nature Commun., 10, 1 2019/01 Refereed English Research paper(scientific journal) Disclose to all
Ishii N, Walinda E, Iwakawa N, Morimoto D, Iwai K, Sugase K, Shirakawa M Ishii N, Walinda E, Iwakawa N, Morimoto D, Iwai K, Sugase K, Shirakawa M Ishii N, Walinda E, Iwakawa N, Morimoto D, Iwai K, Sugase K, Shirakawa M NMR resonance assignments of the NZF domain of mouse HOIL-1L free and bound to linear di-ubiquitin. NMR resonance assignments of the NZF domain of mouse HOIL-1L free and bound to linear di-ubiquitin. NMR resonance assignments of the NZF domain of mouse HOIL-1L free and bound to linear di-ubiquitin. Biomol NMR Assign, 13, 1, 149-153 Biomol NMR Assign, 13, 1, 149-153 Biomol NMR Assign, 13, 1, 149-153 2018/12 Refereed English Research paper(scientific journal) Disclose to all
MacDuff, D.A, Baldridge, M.T, Qaqish, A.M, Nice, T.J, Darbandi, A.D, Hartley, V.L, Peterson, S.T, Miner, J.J, Iwai, K, Virgin, H MacDuff, D.A, Baldridge, M.T, Qaqish, A.M, Nice, T.J, Darbandi, A.D, Hartley, V.L, Peterson, S.T, Miner, J.J, Iwai, K, Virgin, H HOIL1 is essential for the induction of type I and III interferons by MDA5 and regulates persistent murine norovirus infection. HOIL1 is essential for the induction of type I and III interferons by MDA5 and regulates persistent murine norovirus infection. HOIL1 is essential for the induction of type I and III interferons by MDA5 and regulates persistent murine norovirus infection. J. Virol., 92, 23 J. Virol., 92, 23 J. Virol., 92, 23 2018/12 Refereed English Research paper(scientific journal) Disclose to all
Fujita, H, Tokunaga, A, Shimizu, S, Whiting, A. L, Aguilar-Alonso, F, Takagi, K, Walinda, E, Sasaki, Y, Shimokawa, T, Mizushima, T, Ohki, I, Ariyoshi, M, Tochio, H, Bernal, F, Shirakawa, M, Iwai, K Fujita, H, Tokunaga, A, Shimizu, S, Whiting, A. L, Aguilar-Alonso, F, Takagi, K, Walinda, E, Sasaki, Y, Shimokawa, T, Mizushima, T, Ohki, I, Ariyoshi, M, Tochio, H, Bernal, F, Shirakawa, M, Iwai, K Cooperative domain formation by homologous motifs in HOIL-1L and SHARPIN plays crucial roles in LUBAC stabilization. Cooperative domain formation by homologous motifs in HOIL-1L and SHARPIN plays crucial roles in LUBAC stabilization. Cooperative domain formation by homologous motifs in HOIL-1L and SHARPIN plays crucial roles in LUBAC stabilization. Cell Reports, 23, 4, 1192-1204 Cell Reports, 23, 4, 1192-1204 Cell Reports, 23, 4, 1192-1204 2018/04 Refereed English Research paper(scientific journal) Disclose to all
Sasaki, Y, Iwai, K 岩井 一宏 Sasaki, Y, Iwai, K Crucial role of LUBAC-mediated inhibition of programmed cell death in TLR4-mediated B cell responses and B1b cell development. Crucial role of LUBAC-mediated inhibition of programmed cell death in TLR4-mediated B cell responses and B1b cell development. Crucial role of LUBAC-mediated inhibition of programmed cell death in TLR4-mediated B cell responses and B1b cell development. J. Immunol., 200, 10, 3438-3449 J. Immunol., 200, 10, 3438-3449 J. Immunol., 200, 10, 3438-3449 2018/04 Refereed English Research paper(scientific journal) Disclose to all
Ogura, M, Endo, R, Ishikawa, H, Takeda, Y, Uchida, T, Iwai, K, Kobayashi, K, Ishimori, K 岩井 一宏 Ogura, M, Endo, R, Ishikawa, H, Takeda, Y, Uchida, T, Iwai, K, Kobayashi, K, Ishimori, K Redox-dependent axial ligand replacement and its functional significance in heme-bound iron regulatory proteins. Redox-dependent axial ligand replacement and its functional significance in heme-bound iron regulatory proteins. Redox-dependent axial ligand replacement and its functional significance in heme-bound iron regulatory proteins. J. Inorg. Biochem., 182, 238-248 J. Inorg. Biochem., 182, 238-248 J. Inorg. Biochem., 182, 238-248 2018/02 Refereed English Research paper(scientific journal) Disclose to all
Kaji, S, Maki, T, Kinoshita, H, Uemura, N, Ayaki, T, Kawamoto, Y, Furuta, T, Urushitani, M, Hasegawa, M, Kinoshita, Y, Ono, Y, Mao, X, Quach, T.H, Iwai, K, Dawson, V.L, Dawson, T.M, Takahashi, R 岩井 一宏 Kaji, S, Maki, T, Kinoshita, H, Uemura, N, Ayaki, T, Kawamoto, Y, Furuta, T, Urushitani, M, Hasegawa, M, Kinoshita, Y, Ono, Y, Mao, X, Quach, T.H, Iwai, K, Dawson, V.L, Dawson, T.M, Takahashi, R Pathological Endogenous α-Synuclein Accumulation in Oligodendrocyte Precursor Cells Potentially Induces Inclusions in Multiple System Atrophy. Pathological Endogenous α-Synuclein Accumulation in Oligodendrocyte Precursor Cells Potentially Induces Inclusions in Multiple System Atrophy. Pathological Endogenous α-Synuclein Accumulation in Oligodendrocyte Precursor Cells Potentially Induces Inclusions in Multiple System Atrophy. Stem Cell Reports, 10, 2, 356-365 Stem Cell Reports, 10, 2, 356-365 Stem Cell Reports, 10, 2, 356-365 2018/02 Refereed English Research paper(scientific journal) Disclose to all
Tamiya, H, Kim, H, Klymenko, O, Kim, H, Feng, Y, Zhang, T, Han, J.Y, Murao, A, Snipas, S.J, Jilaveanu, L, Brown, K, Kluger, H, Zhang, H, Iwai, K, Ronai, Z.A 岩井 一宏 Tamiya, H, Kim, H, Klymenko, O, Kim, H, Feng, Y, Zhang, T, Han, J.Y, Murao, A, Snipas, S.J, Jilaveanu, L, Brown, K, Kluger, H, Zhang, H, Iwai, K, Ronai, Z.A SHARPIN-mediated regulation of protein arginine methyltransferase 5 controls melanoma growth. SHARPIN-mediated regulation of protein arginine methyltransferase 5 controls melanoma growth. SHARPIN-mediated regulation of protein arginine methyltransferase 5 controls melanoma growth. J. Clin. Invest., 128, 1, 517-530 J. Clin. Invest., 128, 1, 517-530 J. Clin. Invest., 128, 1, 517-530 2018/01 Refereed English Research paper(scientific journal) Disclose to all
Natalia D. Magnani, Laura A. Dada, Markus A. Queisser, Patricia L. Brazee, Lynn C. Welch, Kishore R. Anekalla, Guofei Zhou, Olga Vagin, Alexander V. Misharin, G. R. Scott Budinger, Kazuhiro Iwai, Aaron J. Ciechanover, Jacob I. Sznajder 岩井 一宏 Natalia D. Magnani, Laura A. Dada, Markus A. Queisser, Patricia L. Brazee, Lynn C. Welch, Kishore R. Anekalla, Guofei Zhou, Olga Vagin, Alexander V. Misharin, G. R. Scott Budinger, Kazuhiro Iwai, Aaron J. Ciechanover, Jacob I. Sznajder HIF and HOIL-1L-mediated PKC zeta degradation stabilizes plasma membrane Na,K-ATPase to protect against hypoxia-induced lung injury HOIL-1L-mediated PKCζ degradation stabilizes plasma membrane Na,K-ATPase to protect against hypoxia-induced lung injury. HIF and HOIL-1L-mediated PKC zeta degradation stabilizes plasma membrane Na,K-ATPase to protect against hypoxia-induced lung injury PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 114, 47, E10178-E10186 Proc. Natl. Acad. Sci. USA., 114, 47, E10178-E10186 PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 114, 47, E10178-E10186 2017/11 Refereed English Research paper(scientific journal) Disclose to all
Yukiko Yoshida, Sayaka Yasuda, Toshiharu Fujita, Maho Hamasaki, Arisa Murakami, Junko Kawawaki, Kazuhiro Iwai, Yasushi Saeki, Tamotsu Yoshimori, Noriyuki Matsuda, Keiji Tanaka Yukiko Yoshida, Sayaka Yasuda, Toshiharu Fujita, Maho Hamasaki, Arisa Murakami, Junko Kawawaki, Kazuhiro Iwai, Yasushi Saeki, Tamotsu Yoshimori, Noriyuki Matsuda, Keiji Tanaka Yukiko Yoshida, Sayaka Yasuda, Toshiharu Fujita, Maho Hamasaki, Arisa Murakami, Junko Kawawaki, Kazuhiro Iwai, Yasushi Saeki, Tamotsu Yoshimori, Noriyuki Matsuda, Keiji Tanaka Ubiquitination of exposed glycoproteins by SCFFBXO27 directs damaged lysosomes for autophagy Ubiquitination of exposed glycoproteins by SCFFBXO27 directs damaged lysosomes for autophagy Ubiquitination of exposed glycoproteins by SCFFBXO27 directs damaged lysosomes for autophagy PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 114, 32, 8574-8579 PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 114, 32, 8574-8579 PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 114, 32, 8574-8579 2017/08 Refereed English Research paper(scientific journal) Disclose to all
Yuri Shibata, Fuminori Tokunaga, Eiji Goto, Ginga Komatsu, Jin Gohda, Yasushi Saeki, Keiji Tanaka, Hirotaka Takahashi, Tatsuya Sawasaki, Satoshi Inoue, Hiroyuki Oshiumi, Tsukasa Seya, Hiroyasu Nakano, Yuetsu Tanaka, Kazuhiro Iwai, Jun-ichiro Inoue Yuri Shibata, Fuminori Tokunaga, Eiji Goto, Ginga Komatsu, Jin Gohda, Yasushi Saeki, Keiji Tanaka, Hirotaka Takahashi, Tatsuya Sawasaki, Satoshi Inoue, Hiroyuki Oshiumi, Tsukasa Seya, Hiroyasu Nakano, Yuetsu Tanaka, Kazuhiro Iwai, Jun-ichiro Inoue Yuri Shibata, Fuminori Tokunaga, Eiji Goto, Ginga Komatsu, Jin Gohda, Yasushi Saeki, Keiji Tanaka, Hirotaka Takahashi, Tatsuya Sawasaki, Satoshi Inoue, Hiroyuki Oshiumi, Tsukasa Seya, Hiroyasu Nakano, Yuetsu Tanaka, Kazuhiro Iwai, Jun-ichiro Inoue HTLV-1 Tax Induces Formation of the Active Macromolecular IKK Complex by Generating Lys63-and Met1-Linked Hybrid Polyubiquitin Chains HTLV-1 Tax Induces Formation of the Active Macromolecular IKK Complex by Generating Lys63-and Met1-Linked Hybrid Polyubiquitin Chains HTLV-1 Tax Induces Formation of the Active Macromolecular IKK Complex by Generating Lys63-and Met1-Linked Hybrid Polyubiquitin Chains PLOS PATHOGENS, 13, 1 PLOS PATHOGENS, 13, 1 PLOS PATHOGENS, 13, 1 2017/01 Refereed English Research paper(scientific journal) Disclose to all
Kazumi Okamura, Akiko Kitamura, Yoshiteru Sasaki, Doo Hyun Chung, Shoji Kagami, Kazuhiro Iwai, Koji Yasutomo Kazumi Okamura, Akiko Kitamura, Yoshiteru Sasaki, Doo Hyun Chung, Shoji Kagami, Kazuhiro Iwai, Koji Yasutomo Kazumi Okamura, Akiko Kitamura, Yoshiteru Sasaki, Doo Hyun Chung, Shoji Kagami, Kazuhiro Iwai, Koji Yasutomo Survival of mature T cells depends on signaling through HOIP Survival of mature T cells depends on signaling through HOIP Survival of mature T cells depends on signaling through HOIP SCIENTIFIC REPORTS, 6, 36135 SCIENTIFIC REPORTS, 6, 36135 SCIENTIFIC REPORTS, 6, 36135 2016/10 Refereed English Research paper(scientific journal) Disclose to all
Emi Yamano, Masahiro Sugimoto, Akiyoshi Hirayama, Satoshi Kume, Masanori Yamato, Guanghua Jin, Seiki Tajima, Nobuhito Goda, Kazuhiro Iwai, Sanae Fukuda, Kouzi Yamaguti, Hirohiko Kuratsune, Tomoyoshi Soga, Yasuyoshi Watanabe, Yosky Kataoka Emi Yamano, Masahiro Sugimoto, Akiyoshi Hirayama, Satoshi Kume, Masanori Yamato, Guanghua Jin, Seiki Tajima, Nobuhito Goda, Kazuhiro Iwai, Sanae Fukuda, Kouzi Yamaguti, Hirohiko Kuratsune, Tomoyoshi Soga, Yasuyoshi Watanabe, Yosky Kataoka Emi Yamano, Masahiro Sugimoto, Akiyoshi Hirayama, Satoshi Kume, Masanori Yamato, Guanghua Jin, Seiki Tajima, Nobuhito Goda, Kazuhiro Iwai, Sanae Fukuda, Kouzi Yamaguti, Hirohiko Kuratsune, Tomoyoshi Soga, Yasuyoshi Watanabe, Yosky Kataoka Index markers of chronic fatigue syndrome with dysfunction of TCA and urea cycles Index markers of chronic fatigue syndrome with dysfunction of TCA and urea cycles Index markers of chronic fatigue syndrome with dysfunction of TCA and urea cycles SCIENTIFIC REPORTS, 6, 34990 SCIENTIFIC REPORTS, 6, 34990 SCIENTIFIC REPORTS, 6, 34990 2016/10 Refereed English Research paper(scientific journal) Disclose to all
Seshiru Nakazawa, Daisuke Oikawa, Ryohei Ishii, Takashi Ayaki, Hirotaka Takahashi, Hiroyuki Takeda, Ryuichiro Ishitani, Kiyoko Kamei, Izumi Takeyoshi, Hideshi Kawakami, Kazuhiro Iwai, Izuho Hatada, Tatsuya Sawasaki, Hidefumi Ito, Osamu Nureki, Fuminori Tokunaga Seshiru Nakazawa, Daisuke Oikawa, Ryohei Ishii, Takashi Ayaki, Hirotaka Takahashi, Hiroyuki Takeda, Ryuichiro Ishitani, Kiyoko Kamei, Izumi Takeyoshi, Hideshi Kawakami, Kazuhiro Iwai, Izuho Hatada, Tatsuya Sawasaki, Hidefumi Ito, Osamu Nureki, Fuminori Tokunaga Seshiru Nakazawa, Daisuke Oikawa, Ryohei Ishii, Takashi Ayaki, Hirotaka Takahashi, Hiroyuki Takeda, Ryuichiro Ishitani, Kiyoko Kamei, Izumi Takeyoshi, Hideshi Kawakami, Kazuhiro Iwai, Izuho Hatada, Tatsuya Sawasaki, Hidefumi Ito, Osamu Nureki, Fuminori Tokunaga Linear ubiquitination is involved in the pathogenesis of optineurin-associated amyotrophic lateral sclerosis Linear ubiquitination is involved in the pathogenesis of optineurin-associated amyotrophic lateral sclerosis Linear ubiquitination is involved in the pathogenesis of optineurin-associated amyotrophic lateral sclerosis NATURE COMMUNICATIONS, 7, 12547 NATURE COMMUNICATIONS, 7, 12547 NATURE COMMUNICATIONS, 7, 12547 2016/08 Refereed English Research paper(scientific journal) Disclose to all
Kazuo Kobayashi, Megumi Nakagaki, Haruto Ishikawa, Kazuhiro Iwai, Mark R. O'Brian, Koichiro Ishimori Kazuo Kobayashi, Megumi Nakagaki, Haruto Ishikawa, Kazuhiro Iwai, Mark R. O'Brian, Koichiro Ishimori Kazuo Kobayashi, Megumi Nakagaki, Haruto Ishikawa, Kazuhiro Iwai, Mark R. O'Brian, Koichiro Ishimori Redox-Dependent Dynamics in Heme-Bound Bacterial Iron Response Regulator (Irr) Protein Redox-Dependent Dynamics in Heme-Bound Bacterial Iron Response Regulator (Irr) Protein Redox-Dependent Dynamics in Heme-Bound Bacterial Iron Response Regulator (Irr) Protein BIOCHEMISTRY, 55, 29, 4047-4054 BIOCHEMISTRY, 55, 29, 4047-4054 BIOCHEMISTRY, 55, 29, 4047-4054 2016/07 Refereed English Research paper(scientific journal) Disclose to all
Satoshi Shimizu, Hiroaki Fujita, Yoshiteru Sasaki, Tatsuaki Tsuruyama, Kazuhiko Fukuda, Kazuhiro Iwai Satoshi Shimizu, Hiroaki Fujita, Yoshiteru Sasaki, Tatsuaki Tsuruyama, Kazuhiko Fukuda, Kazuhiro Iwai Satoshi Shimizu, Hiroaki Fujita, Yoshiteru Sasaki, Tatsuaki Tsuruyama, Kazuhiko Fukuda, Kazuhiro Iwai Differential Involvement of the Npl4 Zinc Finger Domains of SHARPIN and HOIL-1L in Linear Ubiquitin Chain Assembly Complex-Mediated Cell Death Protection Differential Involvement of the Npl4 Zinc Finger Domains of SHARPIN and HOIL-1L in Linear Ubiquitin Chain Assembly Complex-Mediated Cell Death Protection Differential Involvement of the Npl4 Zinc Finger Domains of SHARPIN and HOIL-1L in Linear Ubiquitin Chain Assembly Complex-Mediated Cell Death Protection MOLECULAR AND CELLULAR BIOLOGY, 36, 10, 1569-1583 MOLECULAR AND CELLULAR BIOLOGY, 36, 10, 1569-1583 MOLECULAR AND CELLULAR BIOLOGY, 36, 10, 1569-1583 2016/05 Refereed English Research paper(scientific journal) Disclose to all
Yoshiteru Sasaki, Kazuhiro Iwai 岩井 一宏 Yoshiteru Sasaki, Kazuhiro Iwai Roles of the NF-kappa B Pathway in B-Lymphocyte Biology Roles of the NF-κB Pathway in B-Lymphocyte Biology. Roles of the NF-kappa B Pathway in B-Lymphocyte Biology B CELL RECEPTOR SIGNALING, 393, 177-209 Curr. Top. Microbiol. Immunol., 393, 177-209 B CELL RECEPTOR SIGNALING, 393, 177-209 2016 Refereed English Disclose to all
Daisuke Morita, Yukie Yamamoto, Tatsuaki Mizutani, Takeshi Ishikawa, Juri Suzuki, Tatsuhiko Igarashi, Naoki Mori, Takashi Shiina, Hidetoshi Inoko, Hiroaki Fujita, Kazuhiro Iwai, Yoshimasa Tanaka, Bunzo Mikami, Masahiko Sugita Daisuke Morita, Yukie Yamamoto, Tatsuaki Mizutani, Takeshi Ishikawa, Juri Suzuki, Tatsuhiko Igarashi, Naoki Mori, Takashi Shiina, Hidetoshi Inoko, Hiroaki Fujita, Kazuhiro Iwai, Yoshimasa Tanaka, Bunzo Mikami, Masahiko Sugita Daisuke Morita, Yukie Yamamoto, Tatsuaki Mizutani, Takeshi Ishikawa, Juri Suzuki, Tatsuhiko Igarashi, Naoki Mori, Takashi Shiina, Hidetoshi Inoko, Hiroaki Fujita, Kazuhiro Iwai, Yoshimasa Tanaka, Bunzo Mikami, Masahiko Sugita Crystal structure of the N-myristoylated lipopeptide-bound MHC class I complex Crystal structure of the N-myristoylated lipopeptide-bound MHC class I complex Crystal structure of the N-myristoylated lipopeptide-bound MHC class I complex NATURE COMMUNICATIONS, 7, 10356. NATURE COMMUNICATIONS, 7, 10356. NATURE COMMUNICATIONS, 7, 10356. 2016/01 Refereed English Research paper(scientific journal) Disclose to all
Chihiro Kitatsuji, Kozue Izumi, Shusuke Nambu, Masaki Kurogochi, Takeshi Uchida, Shin-Ichiro Nishimura, Kazuhiro Iwai, Mark R. O'Brian, Masao Ikeda-Saito, Koichiro Ishimori Chihiro Kitatsuji, Kozue Izumi, Shusuke Nambu, Masaki Kurogochi, Takeshi Uchida, Shin-Ichiro Nishimura, Kazuhiro Iwai, Mark R. O'Brian, Masao Ikeda-Saito, Koichiro Ishimori Chihiro Kitatsuji, Kozue Izumi, Shusuke Nambu, Masaki Kurogochi, Takeshi Uchida, Shin-Ichiro Nishimura, Kazuhiro Iwai, Mark R. O'Brian, Masao Ikeda-Saito, Koichiro Ishimori Protein oxidation mediated by heme-induced active site conversion specific for heme-regulated transcription factor, iron response regulator Protein oxidation mediated by heme-induced active site conversion specific for heme-regulated transcription factor, iron response regulator Protein oxidation mediated by heme-induced active site conversion specific for heme-regulated transcription factor, iron response regulator SCIENTIFIC REPORTS, 6, 18703 SCIENTIFIC REPORTS, 6, 18703 SCIENTIFIC REPORTS, 6, 18703 2016/01 Refereed English Research paper(scientific journal) Disclose to all
James Bowman, Mary A. Rodgers, Mude Shi, Rina Amatya, Bruce Hostager, Kazuhiro Iwai, Shou-Jiang Gao, Jae U. Jung James Bowman, Mary A. Rodgers, Mude Shi, Rina Amatya, Bruce Hostager, Kazuhiro Iwai, Shou-Jiang Gao, Jae U. Jung James Bowman, Mary A. Rodgers, Mude Shi, Rina Amatya, Bruce Hostager, Kazuhiro Iwai, Shou-Jiang Gao, Jae U. Jung Posttranslational Modification of HOIP Blocks Toll-Like Receptor 4-Mediated Linear-Ubiquitin-Chain Formation Posttranslational Modification of HOIP Blocks Toll-Like Receptor 4-Mediated Linear-Ubiquitin-Chain Formation Posttranslational Modification of HOIP Blocks Toll-Like Receptor 4-Mediated Linear-Ubiquitin-Chain Formation MBIO, 6, 6, e01777-15 MBIO, 6, 6, e01777-15 MBIO, 6, 6, e01777-15 2015/11 Refereed English Research paper(scientific journal) Disclose to all
Taichi Kumanomidou, Kazuya Nishio, Kenji Takagi, Tomomi Nakagawa, Atsuo Suzuki, Takashi Yamane, Fuminori Tokunaga, Kazuhiro Iwai, Arisa Murakami, Yukiko Yoshida, Keiji Tanaka, Tsunehiro Mizushima Taichi Kumanomidou, Kazuya Nishio, Kenji Takagi, Tomomi Nakagawa, Atsuo Suzuki, Takashi Yamane, Fuminori Tokunaga, Kazuhiro Iwai, Arisa Murakami, Yukiko Yoshida, Keiji Tanaka, Tsunehiro Mizushima Taichi Kumanomidou, Kazuya Nishio, Kenji Takagi, Tomomi Nakagawa, Atsuo Suzuki, Takashi Yamane, Fuminori Tokunaga, Kazuhiro Iwai, Arisa Murakami, Yukiko Yoshida, Keiji Tanaka, Tsunehiro Mizushima The Structural Differences between a Glycoprotein Specific F-Box Protein Fbs1 and Its Homologous Protein FBG3 The Structural Differences between a Glycoprotein Specific F-Box Protein Fbs1 and Its Homologous Protein FBG3 The Structural Differences between a Glycoprotein Specific F-Box Protein Fbs1 and Its Homologous Protein FBG3 PLOS ONE, 10, 10, e0140366 PLOS ONE, 10, 10, e0140366 PLOS ONE, 10, 10, e0140366 2015/10 Refereed English Research paper(scientific journal) Disclose to all
Yongge Zhao, Chi A. Ma, Liming Wu, Kazuhiro Iwai, Jonathan D. Ashwell, Eugene M. Oltz, Dean W. Ballard, Ashish Jain Yongge Zhao, Chi A. Ma, Liming Wu, Kazuhiro Iwai, Jonathan D. Ashwell, Eugene M. Oltz, Dean W. Ballard, Ashish Jain Yongge Zhao, Chi A. Ma, Liming Wu, Kazuhiro Iwai, Jonathan D. Ashwell, Eugene M. Oltz, Dean W. Ballard, Ashish Jain CYLD and the NEMO Zinc Finger Regulate Tumor Necrosis Factor Signaling and Early Embryogenesis CYLD and the NEMO Zinc Finger Regulate Tumor Necrosis Factor Signaling and Early Embryogenesis CYLD and the NEMO Zinc Finger Regulate Tumor Necrosis Factor Signaling and Early Embryogenesis JOURNAL OF BIOLOGICAL CHEMISTRY, 290, 36, 22076-22084 JOURNAL OF BIOLOGICAL CHEMISTRY, 290, 36, 22076-22084 JOURNAL OF BIOLOGICAL CHEMISTRY, 290, 36, 22076-22084 2015/09 Refereed English Research paper(scientific journal) Disclose to all
Takeshi Asano, Masato Koike, Shin-ichi Sakata, Yukiko Takeda, Tomoko Nakagawa, Taku Hatano, Satoshi Ohashi, Manabu Funayama, Kenji Yoshimi, Masato Asanuma, Shinya Toyokuni, Hideki Mochizuki, Yasuo Uchiyama, Nobutaka Hattori, Kazuhiro Iwai Takeshi Asano, Masato Koike, Shin-ichi Sakata, Yukiko Takeda, Tomoko Nakagawa, Taku Hatano, Satoshi Ohashi, Manabu Funayama, Kenji Yoshimi, Masato Asanuma, Shinya Toyokuni, Hideki Mochizuki, Yasuo Uchiyama, Nobutaka Hattori, Kazuhiro Iwai Takeshi Asano, Masato Koike, Shin-ichi Sakata, Yukiko Takeda, Tomoko Nakagawa, Taku Hatano, Satoshi Ohashi, Manabu Funayama, Kenji Yoshimi, Masato Asanuma, Shinya Toyokuni, Hideki Mochizuki, Yasuo Uchiyama, Nobutaka Hattori, Kazuhiro Iwai Possible involvement of iron-induced oxidative insults in neurodegeneration Possible involvement of iron-induced oxidative insults in neurodegeneration Possible involvement of iron-induced oxidative insults in neurodegeneration NEUROSCIENCE LETTERS, 588, 29-35 NEUROSCIENCE LETTERS, 588, 29-35 NEUROSCIENCE LETTERS, 588, 29-35 2015/02 Refereed English Research paper(scientific journal) Disclose to all
Sasaki Y, Fujita H, Nakai M, Iwai K Sasaki Y, Fujita H, Nakai M, Iwai K Sasaki Y, Fujita H, Nakai M, Iwai K Immunoblot analysis of linear polyubiquitination of NEMO. Immunoblot analysis of linear polyubiquitination of NEMO. Immunoblot analysis of linear polyubiquitination of NEMO. Methods in molecular biology (Clifton, N.J.), 1280, 297-309 Methods in molecular biology (Clifton, N.J.), 1280, 297-309 Methods in molecular biology (Clifton, N.J.), 1280, 297-309 2015 Refereed Disclose to all
Kume S, Yamato M, Tamura Y, Jin G, Nakano M, Miyashige Y, Eguchi A, Ogata Y, Goda N, Iwai K, Yamano E, Watanabe Y, Soga T, Kataoka Y Kume S, Yamato M, Tamura Y, Jin G, Nakano M, Miyashige Y, Eguchi A, Ogata Y, Goda N, Iwai K, Yamano E, Watanabe Y, Soga T, Kataoka Y Kume S, Yamato M, Tamura Y, Jin G, Nakano M, Miyashige Y, Eguchi A, Ogata Y, Goda N, Iwai K, Yamano E, Watanabe Y, Soga T, Kataoka Y Potential biomarkers of fatigue identified by plasma metabolome analysis in rats. Potential biomarkers of fatigue identified by plasma metabolome analysis in rats. Potential biomarkers of fatigue identified by plasma metabolome analysis in rats. PloS one, 10, 3, e0120106 PloS one, 10, 3, e0120106 PloS one, 10, 3, e0120106 2015 Refereed Disclose to all
Sasaki, K, Iwai, K 岩井 一宏 Sasaki, K, Iwai, K Roles of linear ubiquitinylation, a crucial regulator of NF-κB and cell death, in the immune system. Roles of linear ubiquitinylation, a crucial regulator of NF-κB and cell death, in the immune system. Roles of linear ubiquitinylation, a crucial regulator of NF-κB and cell death, in the immune system. Immunol. Rev., 266, 1, 175-189 Immunol. Rev., 266, 1, 175-189 Immunol. Rev., 266, 1, 175-189 2015 Refereed English Research paper(scientific journal) Disclose to all
Donna A. MacDuff, Tiffany A. Reese, Jacqueline M. Kimmey, Leslie A. Weiss, Christina Song, Xin Zhang, Amal Kambal, Erning Duan, Javier A. Carrero, Bertrand Boisson, Emmanuel Laplantine, Alain Israel, Capucine Picard, Marco Colonna, Brian T. Edelson, L. David Sibley, Christina L. Stallings, Jean-Laurent Casanova, Kazuhiro Iwai, Herbert W. Virgin Donna A. MacDuff, Tiffany A. Reese, Jacqueline M. Kimmey, Leslie A. Weiss, Christina Song, Xin Zhang, Amal Kambal, Erning Duan, Javier A. Carrero, Bertrand Boisson, Emmanuel Laplantine, Alain Israel, Capucine Picard, Marco Colonna, Brian T. Edelson, L. David Sibley, Christina L. Stallings, Jean-Laurent Casanova, Kazuhiro Iwai, Herbert W. Virgin Donna A. MacDuff, Tiffany A. Reese, Jacqueline M. Kimmey, Leslie A. Weiss, Christina Song, Xin Zhang, Amal Kambal, Erning Duan, Javier A. Carrero, Bertrand Boisson, Emmanuel Laplantine, Alain Israel, Capucine Picard, Marco Colonna, Brian T. Edelson, L. David Sibley, Christina L. Stallings, Jean-Laurent Casanova, Kazuhiro Iwai, Herbert W. Virgin Phenotypic complementation of genetic immunodeficiency by chronic herpesvirus infection Phenotypic complementation of genetic immunodeficiency by chronic herpesvirus infection Phenotypic complementation of genetic immunodeficiency by chronic herpesvirus infection ELIFE, 4, e04494 ELIFE, 4, e04494 ELIFE, 4, e04494 2015/01 Refereed English Research paper(scientific journal) Disclose to all
Daichi Morimoto, Erik Walinda, Harumi Fukada, Yu-Shin Sou, Shun Kageyama, Masaru Hoshino, Takashi Fujii, Hikaru Tsuchiya, Yasushi Saeki, Kyohei Arita, Mariko Ariyoshi, Hidehito Tochio, Kazuhiro Iwai, Keiichi Namba, Masaaki Komatsu, Keiji Tanaka, Masahiro Shirakawa Daichi Morimoto, Erik Walinda, Harumi Fukada, Yu-Shin Sou, Shun Kageyama, Masaru Hoshino, Takashi Fujii, Hikaru Tsuchiya, Yasushi Saeki, Kyohei Arita, Mariko Ariyoshi, Hidehito Tochio, Kazuhiro Iwai, Keiichi Namba, Masaaki Komatsu, Keiji Tanaka, Masahiro Shirakawa Daichi Morimoto, Erik Walinda, Harumi Fukada, Yu-Shin Sou, Shun Kageyama, Masaru Hoshino, Takashi Fujii, Hikaru Tsuchiya, Yasushi Saeki, Kyohei Arita, Mariko Ariyoshi, Hidehito Tochio, Kazuhiro Iwai, Keiichi Namba, Masaaki Komatsu, Keiji Tanaka, Masahiro Shirakawa The unexpected role of polyubiquitin chains in the formation of fibrillar aggregates The unexpected role of polyubiquitin chains in the formation of fibrillar aggregates The unexpected role of polyubiquitin chains in the formation of fibrillar aggregates Nature Communications, 6, 6116 Nature Communications, 6, 6116 Nature Communications, 6, 6116 2015/01 Refereed English Research paper(scientific journal) Disclose to all
Sakamoto, H, Egashira, S, Saito, N, Kirisako, T, Miller, S, Sasaki, Y, Matsumoto, T, Shimonishi, M, Komatsu, T, Terai, T, Ueno, T, Hanaoka, K, Kojima, H, Okabe, T, Wakatsuki, S, Iwai, K, corresponding author, Nagano, T 岩井 一宏 Sakamoto, H, Egashira, S, Saito, N, Kirisako, T, Miller, S, Sasaki, Y, Matsumoto, T, Shimonishi, M, Komatsu, T, Terai, T, Ueno, T, Hanaoka, K, Kojima, H, Okabe, T, Wakatsuki, S, Iwai, K, corresponding author, Nagano, T Gliotoxin suppresses NF-κB activation by selectively inhibiting linear ubiquitin chain assembly complex (LUBAC). Gliotoxin suppresses NF-κB activation by selectively inhibiting linear ubiquitin chain assembly complex (LUBAC). Gliotoxin suppresses NF-κB activation by selectively inhibiting linear ubiquitin chain assembly complex (LUBAC). ACS Chem. Biol. ACS Chem. Biol. ACS Chem. Biol. 2014/12 Refereed English Research paper(scientific journal) Disclose to all
Kazuhiro Iwai, Keiji Tanaka Kazuhiro Iwai, Keiji Tanaka Kazuhiro Iwai, Keiji Tanaka Ubiquitin Chain Elongation: An Intriguing Strategy Ubiquitin Chain Elongation: An Intriguing Strategy Ubiquitin Chain Elongation: An Intriguing Strategy MOLECULAR CELL, 56, 2, 189-191 MOLECULAR CELL, 56, 2, 189-191 MOLECULAR CELL, 56, 2, 189-191 2014/10 English Research paper(scientific journal) Disclose to all
Markus A. Queisser, Laura A. Dada, Nimrod Deiss-Yehiely, Martin Angulo, Guofei Zhou, Fotini M. Kouri, Lawrence M. Knab, Jing Liu, Alexander H. Stegh, Malcolm M. DeCamp, G. R. Scott Budinger, Navdeep S. Chandel, Aaron Ciechanover, Kazuhiro Lwai, Jacob I. Sznajder 岩井 一宏 Markus A. Queisser, Laura A. Dada, Nimrod Deiss-Yehiely, Martin Angulo, Guofei Zhou, Fotini M. Kouri, Lawrence M. Knab, Jing Liu, Alexander H. Stegh, Malcolm M. DeCamp, G. R. Scott Budinger, Navdeep S. Chandel, Aaron Ciechanover, Kazuhiro Lwai, Jacob I. Sznajder HOIL-1L Functions as the PKC zeta Ubiquitin Ligase to Promote Lung Tumor Growth HOIL-1L Functions as the PKCζ Ubiquitin Ligase to Promote Lung Tumor Growth. HOIL-1L Functions as the PKC zeta Ubiquitin Ligase to Promote Lung Tumor Growth AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE, 190, 6, 688-698 Am. J. Respir. Crit. Care Med., 190, 6, 688-698 AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE, 190, 6, 688-698 2014/09 Refereed English Research paper(scientific journal) Disclose to all
Kazuhiro Iwai, Hiroaki Fujita, Yoshiteru Sasaki 岩井 一宏 Kazuhiro Iwai, Hiroaki Fujita, Yoshiteru Sasaki Linear ubiquitin chains: NF-kappa B signalling, cell death and beyond Linear ubiquitin chains: NF-κB signalling, cell death, and beyond. Linear ubiquitin chains: NF-kappa B signalling, cell death and beyond NATURE REVIEWS MOLECULAR CELL BIOLOGY, 15, 8, 503-508 Nature Rev. Mol. Cell Biol., 15, 8, 503-508 NATURE REVIEWS MOLECULAR CELL BIOLOGY, 15, 8, 503-508 2014/08 Refereed English Research paper(scientific journal) Disclose to all
Mary A. Rodgers, James W. Bowman, Hiroaki Fujita, Nicole Orazio, Mude Shi, Qiming Liang, Rina Amatya, Thomas J. Kelly, Kazuhiro Iwai, Jenny Ting, Jae U. Jung Mary A. Rodgers, James W. Bowman, Hiroaki Fujita, Nicole Orazio, Mude Shi, Qiming Liang, Rina Amatya, Thomas J. Kelly, Kazuhiro Iwai, Jenny Ting, Jae U. Jung Mary A. Rodgers, James W. Bowman, Hiroaki Fujita, Nicole Orazio, Mude Shi, Qiming Liang, Rina Amatya, Thomas J. Kelly, Kazuhiro Iwai, Jenny Ting, Jae U. Jung The linear ubiquitin assembly complex (LUBAC) is essential for NLRP3 inflammasome activation The linear ubiquitin assembly complex (LUBAC) is essential for NLRP3 inflammasome activation The linear ubiquitin assembly complex (LUBAC) is essential for NLRP3 inflammasome activation JOURNAL OF EXPERIMENTAL MEDICINE, 211, 7, 1331-1345 JOURNAL OF EXPERIMENTAL MEDICINE, 211, 7, 1331-1345 JOURNAL OF EXPERIMENTAL MEDICINE, 211, 7, 1331-1345 2014/06 Refereed English Research paper(scientific journal) Disclose to all
Hiroaki Fujita, Simin Rahighi, Mariko Akita, Ryuichi Kato, Yoshiteru Sasaki, Soichi Wakatsuki, Kazuhiro Iwai Fujita H, Rahighi S, Akita M, Kato R, Sasaki Y, Wakatsuki S, Iwai K Hiroaki Fujita, Simin Rahighi, Mariko Akita, Ryuichi Kato, Yoshiteru Sasaki, Soichi Wakatsuki, Kazuhiro Iwai Mechanism Underlying I kappa B Kinase Activation Mediated by the Linear Ubiquitin Chain Assembly Complex Mechanism underlying IκB kinase activation mediated by the linear ubiquitin chain assembly complex. Mechanism Underlying I kappa B Kinase Activation Mediated by the Linear Ubiquitin Chain Assembly Complex MOLECULAR AND CELLULAR BIOLOGY, 34, 7, 1322-1335 Molecular and cellular biology, 34, 7, 1322-1335 MOLECULAR AND CELLULAR BIOLOGY, 34, 7, 1322-1335 2014/04 Refereed English Research paper(scientific journal) Disclose to all
Hironari Tamiya, Mika Terao, Tsuyoshi Takiuchi, Masaki Nakahara, Yoshiteru Sasaki, Ichiro Katayama, Hideki Yoshikawa, Kazuhiro Iwai 岩井 一宏 Hironari Tamiya, Mika Terao, Tsuyoshi Takiuchi, Masaki Nakahara, Yoshiteru Sasaki, Ichiro Katayama, Hideki Yoshikawa, Kazuhiro Iwai IFN-gamma or IFN-alpha Ameliorates Chronic Proliferative Dermatitis by Inducing Expression of Linear Ubiquitin Chain Assembly Complex IFN-γ or IFN-α ameliorates chronic proliferative dermatitis by inducing expression of linear ubiquitin chain assembly complex. IFN-gamma or IFN-alpha Ameliorates Chronic Proliferative Dermatitis by Inducing Expression of Linear Ubiquitin Chain Assembly Complex JOURNAL OF IMMUNOLOGY, 192, 8, 3793-3804 J. Immunol., 192, 8, 3793-3804 JOURNAL OF IMMUNOLOGY, 192, 8, 3793-3804 2014/04 Refereed English Research paper(scientific journal) Disclose to all
Yibin Yang, Roland Schmitz, Joseph Mitala, Amanda Whiting, Wenming Xiao, Michele Ceribelli, George W. Wright, Hong Zhao, Yandan Yang, Weihong Xu, Andreas Rosenwald, German Ott, Randy D. Gascoyne, Joseph M. Connors, Lisa M. Rimsza, Elias Campo, Elaine S. Jaffe, Jan Delabie, Erlend B. Smeland, Rita M. Braziel, Raymond R. Tubbs, James R. Cook, Dennis D. Weisenburger, Wing C. Chan, Adrian Wiestner, Michael J. Kruhlak, Kazuhiro Iwai, Federico Bernal, Louis M. Staudt Yibin Yang, Roland Schmitz, Joseph Mitala, Amanda Whiting, Wenming Xiao, Michele Ceribelli, George W. Wright, Hong Zhao, Yandan Yang, Weihong Xu, Andreas Rosenwald, German Ott, Randy D. Gascoyne, Joseph M. Connors, Lisa M. Rimsza, Elias Campo, Elaine S. Jaffe, Jan Delabie, Erlend B. Smeland, Rita M. Braziel, Raymond R. Tubbs, James R. Cook, Dennis D. Weisenburger, Wing C. Chan, Adrian Wiestner, Michael J. Kruhlak, Kazuhiro Iwai, Federico Bernal, Louis M. Staudt Yibin Yang, Roland Schmitz, Joseph Mitala, Amanda Whiting, Wenming Xiao, Michele Ceribelli, George W. Wright, Hong Zhao, Yandan Yang, Weihong Xu, Andreas Rosenwald, German Ott, Randy D. Gascoyne, Joseph M. Connors, Lisa M. Rimsza, Elias Campo, Elaine S. Jaffe, Jan Delabie, Erlend B. Smeland, Rita M. Braziel, Raymond R. Tubbs, James R. Cook, Dennis D. Weisenburger, Wing C. Chan, Adrian Wiestner, Michael J. Kruhlak, Kazuhiro Iwai, Federico Bernal, Louis M. Staudt Essential Role of the Linear Ubiquitin Chain Assembly Complex in Lymphoma Revealed by Rare Germline Polymorphisms Essential Role of the Linear Ubiquitin Chain Assembly Complex in Lymphoma Revealed by Rare Germline Polymorphisms Essential Role of the Linear Ubiquitin Chain Assembly Complex in Lymphoma Revealed by Rare Germline Polymorphisms CANCER DISCOVERY, 4, 4, 480-493 CANCER DISCOVERY, 4, 4, 480-493 CANCER DISCOVERY, 4, 4, 480-493 2014/04 Refereed English Research paper(scientific journal) Disclose to all
Tsuyoshi Takiuchi, Tomoko Nakagawa, Hironari Tamiya, Hiroaki Fujita, Yoshiteru Sasaki, Yasushi Saeki, Hiroyuki Takeda, Tatsuya Sawasaki, Alexander Buchberger, Tadashi Kimura, Kazuhiro Iwai Tsuyoshi Takiuchi, Tomoko Nakagawa, Hironari Tamiya, Hiroaki Fujita, Yoshiteru Sasaki, Yasushi Saeki, Hiroyuki Takeda, Tatsuya Sawasaki, Alexander Buchberger, Tadashi Kimura, Kazuhiro Iwai Tsuyoshi Takiuchi, Tomoko Nakagawa, Hironari Tamiya, Hiroaki Fujita, Yoshiteru Sasaki, Yasushi Saeki, Hiroyuki Takeda, Tatsuya Sawasaki, Alexander Buchberger, Tadashi Kimura, Kazuhiro Iwai Suppression of LUBAC-mediated linear ubiquitination by a specific interaction between LUBAC and the deubiquitinases CYLD and OTULIN Suppression of LUBAC-mediated linear ubiquitination by a specific interaction between LUBAC and the deubiquitinases CYLD and OTULIN Suppression of LUBAC-mediated linear ubiquitination by a specific interaction between LUBAC and the deubiquitinases CYLD and OTULIN GENES TO CELLS, 19, 3, 254-272 GENES TO CELLS, 19, 3, 254-272 GENES TO CELLS, 19, 3, 254-272 2014/03 Refereed English Research paper(scientific journal) Disclose to all
Kazuhiro Iwai Kazuhiro Iwai Kazuhiro Iwai Diverse roles of the ubiquitin system in NF-kappa B activation Diverse roles of the ubiquitin system in NF-kappa B activation Diverse roles of the ubiquitin system in NF-kappa B activation BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH, 1843, 1, 129-136 BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH, 1843, 1, 129-136 BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH, 1843, 1, 129-136 2014/01 Refereed English Disclose to all
Naonobu Fujita, Eiji Morita, Takashi Itoh, Atsushi Tanaka, Megumi Nakaoka, Yuki Osada, Tetsuo Umemoto, Tatsuya Saitoh, Hitoshi Nakatogawa, Shouhei Kobayashi, Tokuko Haraguchi, Jun-Lin Guan, Kazuhiro Iwai, Fuminori Tokunaga, Kazunobu Saito, Koutaro Ishibashi, Shizuo Akira, Mitsunori Fukuda, Takeshi Noda, Tamotsu Yoshimori Naonobu Fujita, Eiji Morita, Takashi Itoh, Atsushi Tanaka, Megumi Nakaoka, Yuki Osada, Tetsuo Umemoto, Tatsuya Saitoh, Hitoshi Nakatogawa, Shouhei Kobayashi, Tokuko Haraguchi, Jun-Lin Guan, Kazuhiro Iwai, Fuminori Tokunaga, Kazunobu Saito, Koutaro Ishibashi, Shizuo Akira, Mitsunori Fukuda, Takeshi Noda, Tamotsu Yoshimori Naonobu Fujita, Eiji Morita, Takashi Itoh, Atsushi Tanaka, Megumi Nakaoka, Yuki Osada, Tetsuo Umemoto, Tatsuya Saitoh, Hitoshi Nakatogawa, Shouhei Kobayashi, Tokuko Haraguchi, Jun-Lin Guan, Kazuhiro Iwai, Fuminori Tokunaga, Kazunobu Saito, Koutaro Ishibashi, Shizuo Akira, Mitsunori Fukuda, Takeshi Noda, Tamotsu Yoshimori Recruitment of the autophagic machinery to endosomes during infection is mediated by ubiquitin Recruitment of the autophagic machinery to endosomes during infection is mediated by ubiquitin Recruitment of the autophagic machinery to endosomes during infection is mediated by ubiquitin JOURNAL OF CELL BIOLOGY, 203, 1, 115-128 JOURNAL OF CELL BIOLOGY, 203, 1, 115-128 JOURNAL OF CELL BIOLOGY, 203, 1, 115-128 2013/10 Refereed English Research paper(scientific journal) Disclose to all
Mineaki Seki, Yukiko Takeda, Kazuhiro Iwai, Kiyoji Tanaka Mineaki Seki, Yukiko Takeda, Kazuhiro Iwai, Kiyoji Tanaka Mineaki Seki, Yukiko Takeda, Kazuhiro Iwai, Kiyoji Tanaka IOP1 Protein Is an External Component of the Human Cytosolic Iron-Sulfur Cluster Assembly (CIA) Machinery and Functions in the MMS19 Protein-dependent CIA Pathway IOP1 Protein Is an External Component of the Human Cytosolic Iron-Sulfur Cluster Assembly (CIA) Machinery and Functions in the MMS19 Protein-dependent CIA Pathway IOP1 Protein Is an External Component of the Human Cytosolic Iron-Sulfur Cluster Assembly (CIA) Machinery and Functions in the MMS19 Protein-dependent CIA Pathway JOURNAL OF BIOLOGICAL CHEMISTRY, 288, 23, 16680-16689 JOURNAL OF BIOLOGICAL CHEMISTRY, 288, 23, 16680-16689 JOURNAL OF BIOLOGICAL CHEMISTRY, 288, 23, 16680-16689 2013/06 Refereed English Research paper(scientific journal) Disclose to all
Ken Blackwell, Laiqun Zhang, Lauren M. Workman, Adrian T. Ting, Kazuhiro Iwai, Hasem Habelhah Ken Blackwell, Laiqun Zhang, Lauren M. Workman, Adrian T. Ting, Kazuhiro Iwai, Hasem Habelhah Ken Blackwell, Laiqun Zhang, Lauren M. Workman, Adrian T. Ting, Kazuhiro Iwai, Hasem Habelhah Two Coordinated Mechanisms Underlie Tumor Necrosis Factor Alpha-Induced Immediate and Delayed I kappa B Kinase Activation Two Coordinated Mechanisms Underlie Tumor Necrosis Factor Alpha-Induced Immediate and Delayed I kappa B Kinase Activation Two Coordinated Mechanisms Underlie Tumor Necrosis Factor Alpha-Induced Immediate and Delayed I kappa B Kinase Activation MOLECULAR AND CELLULAR BIOLOGY, 33, 10, 1901-1915 MOLECULAR AND CELLULAR BIOLOGY, 33, 10, 1901-1915 MOLECULAR AND CELLULAR BIOLOGY, 33, 10, 1901-1915 2013/05 Refereed English Research paper(scientific journal) Disclose to all
Y. Sasaki, S. Sano, M. Nakahara, S. Murata, K. Kometani, Y. Aiba, S. Sakamoto, Y. Watanabe, K. Tanaka, T. Kurosaki, K. Iwai Y. Sasaki, S. Sano, M. Nakahara, S. Murata, K. Kometani, Y. Aiba, S. Sakamoto, Y. Watanabe, K. Tanaka, T. Kurosaki, K. Iwai Y. Sasaki, S. Sano, M. Nakahara, S. Murata, K. Kometani, Y. Aiba, S. Sakamoto, Y. Watanabe, K. Tanaka, T. Kurosaki, K. Iwai Defective immune responses in mice lacking LUBAC-mediated linear ubiquitination in B cells Defective immune responses in mice lacking LUBAC-mediated linear ubiquitination in B cells Defective immune responses in mice lacking LUBAC-mediated linear ubiquitination in B cells EMBO Journal, 32, 18, 2463-2476 EMBO Journal, 32, 18, 2463-2476 EMBO Journal, 32, 18, 2463-2476 2013 Refereed English Disclose to all
Ryo Ueta, Naoko Fujiwara, Kazuhiro Iwai, Yuko Yamaguchi-Iwai Ryo Ueta, Naoko Fujiwara, Kazuhiro Iwai, Yuko Yamaguchi-Iwai Ryo Ueta, Naoko Fujiwara, Kazuhiro Iwai, Yuko Yamaguchi-Iwai Iron-Induced Dissociation of the Aft1p Transcriptional Regulator from Target Gene Promoters Is an Initial Event in Iron-Dependent Gene Suppression Iron-Induced Dissociation of the Aft1p Transcriptional Regulator from Target Gene Promoters Is an Initial Event in Iron-Dependent Gene Suppression Iron-Induced Dissociation of the Aft1p Transcriptional Regulator from Target Gene Promoters Is an Initial Event in Iron-Dependent Gene Suppression MOLECULAR AND CELLULAR BIOLOGY, 32, 24, 4998-5008 MOLECULAR AND CELLULAR BIOLOGY, 32, 24, 4998-5008 MOLECULAR AND CELLULAR BIOLOGY, 32, 24, 4998-5008 2012/12 Refereed English Research paper(scientific journal) Disclose to all
Fuminori Tokunaga, Hiroshi Nishimasu, Ryuichiro Ishitani, Eiji Goto, Takuya Noguchi, Kazuhiro Mio, Kiyoko Kamei, Averil Ma, Kazuhiro Iwai, Osamu Nureki Fuminori Tokunaga, Hiroshi Nishimasu, Ryuichiro Ishitani, Eiji Goto, Takuya Noguchi, Kazuhiro Mio, Kiyoko Kamei, Averil Ma, Kazuhiro Iwai, Osamu Nureki Fuminori Tokunaga, Hiroshi Nishimasu, Ryuichiro Ishitani, Eiji Goto, Takuya Noguchi, Kazuhiro Mio, Kiyoko Kamei, Averil Ma, Kazuhiro Iwai, Osamu Nureki Specific recognition of linear polyubiquitin by A20 zinc finger 7 is involved in NF-kappa B regulation Specific recognition of linear polyubiquitin by A20 zinc finger 7 is involved in NF-kappa B regulation Specific recognition of linear polyubiquitin by A20 zinc finger 7 is involved in NF-kappa B regulation EMBO JOURNAL, 31, 19, 3856-3870 EMBO JOURNAL, 31, 19, 3856-3870 EMBO JOURNAL, 31, 19, 3856-3870 2012/10 Refereed English Research paper(scientific journal) Disclose to all
Yoshinori Uekusa, Syunsuke Mimura, Hiroaki Sasakawa, Eiji Kurimoto, Eri Sakata, Serve Olivier, Hirokazu Yagi, Fuminori Tokunaga, Kazuhiro Iwai, Koichi Kato Yoshinori Uekusa, Syunsuke Mimura, Hiroaki Sasakawa, Eiji Kurimoto, Eri Sakata, Serve Olivier, Hirokazu Yagi, Fuminori Tokunaga, Kazuhiro Iwai, Koichi Kato Yoshinori Uekusa, Syunsuke Mimura, Hiroaki Sasakawa, Eiji Kurimoto, Eri Sakata, Serve Olivier, Hirokazu Yagi, Fuminori Tokunaga, Kazuhiro Iwai, Koichi Kato Backbone and side chain 1H, 13C, and 15N assignments of the ubiquitin-like domain of human HOIL-1L, an essential component of linear ubiquitin chain assembly complex. Backbone and side chain 1H, 13C, and 15N assignments of the ubiquitin-like domain of human HOIL-1L, an essential component of linear ubiquitin chain assembly complex. Backbone and side chain 1H, 13C, and 15N assignments of the ubiquitin-like domain of human HOIL-1L, an essential component of linear ubiquitin chain assembly complex. Biomolecular NMR assignments, 6, 2, 177-80 Biomolecular NMR assignments, 6, 2, 177-80 Biomolecular NMR assignments, 6, 2, 177-80 2012/10 Refereed English Disclose to all
Yoshinori Uekusa, Syunsuke Mimura, Hiroaki Sasakawa, Eiji Kurimoto, Eri Sakata, Serve Olivier, Hirokazu Yagi, Fuminori Tokunaga, Kazuhiro Iwai, Koichi Kato Yoshinori Uekusa, Syunsuke Mimura, Hiroaki Sasakawa, Eiji Kurimoto, Eri Sakata, Serve Olivier, Hirokazu Yagi, Fuminori Tokunaga, Kazuhiro Iwai, Koichi Kato Yoshinori Uekusa, Syunsuke Mimura, Hiroaki Sasakawa, Eiji Kurimoto, Eri Sakata, Serve Olivier, Hirokazu Yagi, Fuminori Tokunaga, Kazuhiro Iwai, Koichi Kato Backbone and side chain 1H, 13C, and 15N assignments of the ubiquitin-like domain of human HOIL-1L, an essential component of linear ubiquitin chain assembly complex. Backbone and side chain 1H, 13C, and 15N assignments of the ubiquitin-like domain of human HOIL-1L, an essential component of linear ubiquitin chain assembly complex. Backbone and side chain 1H, 13C, and 15N assignments of the ubiquitin-like domain of human HOIL-1L, an essential component of linear ubiquitin chain assembly complex. Biomolecular NMR assignments, 6, 2, 177-80 Biomolecular NMR assignments, 6, 2, 177-80 Biomolecular NMR assignments, 6, 2, 177-80 2012/10 Refereed English Disclose to all
S. Mehdi Belgnaoui, Suzanne Paz, Sara Samuel, Marie-Line Goulet, Qiang Sun, Marjolein Kikkert, Kazuhiro Iwai, Ivan Dikic, John Hiscott, Rongtuan Lin S. Mehdi Belgnaoui, Suzanne Paz, Sara Samuel, Marie-Line Goulet, Qiang Sun, Marjolein Kikkert, Kazuhiro Iwai, Ivan Dikic, John Hiscott, Rongtuan Lin S. Mehdi Belgnaoui, Suzanne Paz, Sara Samuel, Marie-Line Goulet, Qiang Sun, Marjolein Kikkert, Kazuhiro Iwai, Ivan Dikic, John Hiscott, Rongtuan Lin Linear Ubiquitination of NEMO Negatively Regulates the Interferon Antiviral Response through Disruption of the MAVS-TRAF3 Complex Linear Ubiquitination of NEMO Negatively Regulates the Interferon Antiviral Response through Disruption of the MAVS-TRAF3 Complex Linear Ubiquitination of NEMO Negatively Regulates the Interferon Antiviral Response through Disruption of the MAVS-TRAF3 Complex CELL HOST & MICROBE, 12, 2, 211-222 CELL HOST & MICROBE, 12, 2, 211-222 CELL HOST & MICROBE, 12, 2, 211-222 2012/08 Refereed English Research paper(scientific journal) Disclose to all
Fuminori Tokunaga, Kazuhiro Iwai Fuminori Tokunaga, Kazuhiro Iwai Fuminori Tokunaga, Kazuhiro Iwai Linear ubiquitination: A novel NF-kappa B regulatory mechanism for inflammatory and immune responses by the LUBAC ubiquitin ligase complex Linear ubiquitination: A novel NF-kappa B regulatory mechanism for inflammatory and immune responses by the LUBAC ubiquitin ligase complex Linear ubiquitination: A novel NF-kappa B regulatory mechanism for inflammatory and immune responses by the LUBAC ubiquitin ligase complex ENDOCRINE JOURNAL, 59, 8, 641-652 ENDOCRINE JOURNAL, 59, 8, 641-652 ENDOCRINE JOURNAL, 59, 8, 641-652 2012/08 Refereed English Disclose to all
Fuminori Tokunaga, Kazuhiro Iwai Fuminori Tokunaga, Kazuhiro Iwai Fuminori Tokunaga, Kazuhiro Iwai LUBAC, a novel ubiquitin ligase for linear ubiquitination, is crucial for inflammation and immune responses LUBAC, a novel ubiquitin ligase for linear ubiquitination, is crucial for inflammation and immune responses LUBAC, a novel ubiquitin ligase for linear ubiquitination, is crucial for inflammation and immune responses MICROBES AND INFECTION, 14, 7-8, 563-572 MICROBES AND INFECTION, 14, 7-8, 563-572 MICROBES AND INFECTION, 14, 7-8, 563-572 2012/07 Refereed English Disclose to all
Kazuhiro Iwai Kazuhiro Iwai Kazuhiro Iwai Diverse ubiquitin signaling in NF-kappa B activation Diverse ubiquitin signaling in NF-kappa B activation Diverse ubiquitin signaling in NF-kappa B activation TRENDS IN CELL BIOLOGY, 22, 7, 355-364 TRENDS IN CELL BIOLOGY, 22, 7, 355-364 TRENDS IN CELL BIOLOGY, 22, 7, 355-364 2012/07 Refereed English Disclose to all
Tobias Kensche, Fuminori Tokunaga, Fumiyo Ikeda, Eiji Goto, Kazuhiro Iwai, Ivan Dikic Tobias Kensche, Fuminori Tokunaga, Fumiyo Ikeda, Eiji Goto, Kazuhiro Iwai, Ivan Dikic Tobias Kensche, Fuminori Tokunaga, Fumiyo Ikeda, Eiji Goto, Kazuhiro Iwai, Ivan Dikic Analysis of Nuclear Factor-kappa B (NF-kappa B) Essential Modulator (NEMO) Binding to Linear and Lysine-linked Ubiquitin Chains and Its Role in the Activation of NF-kappa B Analysis of Nuclear Factor-kappa B (NF-kappa B) Essential Modulator (NEMO) Binding to Linear and Lysine-linked Ubiquitin Chains and Its Role in the Activation of NF-kappa B Analysis of Nuclear Factor-kappa B (NF-kappa B) Essential Modulator (NEMO) Binding to Linear and Lysine-linked Ubiquitin Chains and Its Role in the Activation of NF-kappa B JOURNAL OF BIOLOGICAL CHEMISTRY, 287, 28, 23626-23634 JOURNAL OF BIOLOGICAL CHEMISTRY, 287, 28, 23626-23634 JOURNAL OF BIOLOGICAL CHEMISTRY, 287, 28, 23626-23634 2012/07 Refereed English Research paper(scientific journal) Disclose to all
Hirokazu Yagi, Kazuhiro Ishimoto, Takeshi Hiromoto, Hiroaki Fujita, Tsunehiro Mizushima, Yoshinori Uekusa, Maho Yagi-Utsumi, Eiji Kurimoto, Masanori Noda, Susumu Uchiyama, Fuminori Tokunaga, Kazuhiro Iwai, Koichi Kato Hirokazu Yagi, Kazuhiro Ishimoto, Takeshi Hiromoto, Hiroaki Fujita, Tsunehiro Mizushima, Yoshinori Uekusa, Maho Yagi-Utsumi, Eiji Kurimoto, Masanori Noda, Susumu Uchiyama, Fuminori Tokunaga, Kazuhiro Iwai, Koichi Kato Hirokazu Yagi, Kazuhiro Ishimoto, Takeshi Hiromoto, Hiroaki Fujita, Tsunehiro Mizushima, Yoshinori Uekusa, Maho Yagi-Utsumi, Eiji Kurimoto, Masanori Noda, Susumu Uchiyama, Fuminori Tokunaga, Kazuhiro Iwai, Koichi Kato A non-canonical UBA-UBL interaction forms the linear-ubiquitin-chain assembly complex. A non-canonical UBA-UBL interaction forms the linear-ubiquitin-chain assembly complex. A non-canonical UBA-UBL interaction forms the linear-ubiquitin-chain assembly complex. EMBO reports, 13, 5, 462-8 EMBO reports, 13, 5, 462-8 EMBO reports, 13, 5, 462-8 2012/05/01 Refereed English Disclose to all
Hirokazu Yagi, Kazuhiro Ishimoto, Takeshi Hiromoto, Hiroaki Fujita, Tsunehiro Mizushima, Yoshinori Uekusa, Maho Yagi-Utsumi, Eiji Kurimoto, Masanori Noda, Susumu Uchiyama, Fuminori Tokunaga, Kazuhiro Iwai, Koichi Kato Hirokazu Yagi, Kazuhiro Ishimoto, Takeshi Hiromoto, Hiroaki Fujita, Tsunehiro Mizushima, Yoshinori Uekusa, Maho Yagi-Utsumi, Eiji Kurimoto, Masanori Noda, Susumu Uchiyama, Fuminori Tokunaga, Kazuhiro Iwai, Koichi Kato Hirokazu Yagi, Kazuhiro Ishimoto, Takeshi Hiromoto, Hiroaki Fujita, Tsunehiro Mizushima, Yoshinori Uekusa, Maho Yagi-Utsumi, Eiji Kurimoto, Masanori Noda, Susumu Uchiyama, Fuminori Tokunaga, Kazuhiro Iwai, Koichi Kato A non-canonical UBA-UBL interaction forms the linear-ubiquitin-chain assembly complex. A non-canonical UBA-UBL interaction forms the linear-ubiquitin-chain assembly complex. A non-canonical UBA-UBL interaction forms the linear-ubiquitin-chain assembly complex. EMBO reports, 13, 5, 462-8 EMBO reports, 13, 5, 462-8 EMBO reports, 13, 5, 462-8 2012/05/01 Refereed English Disclose to all
Henning Walczak, Kazuhiro Iwai, Ivan Dikic Henning Walczak, Kazuhiro Iwai, Ivan Dikic Henning Walczak, Kazuhiro Iwai, Ivan Dikic Generation and physiological roles of linear ubiquitin chains Generation and physiological roles of linear ubiquitin chains Generation and physiological roles of linear ubiquitin chains BMC BIOLOGY, 10 BMC BIOLOGY, 10 BMC BIOLOGY, 10 2012/03 Refereed English Disclose to all
Masato Tomonaga, Nobuyuki Hashimoto, Fuminori Tokunaga, Megumi Onishi, Akira Myoui, Hideki Yoshikawa, Kazuhiro Iwai Masato Tomonaga, Nobuyuki Hashimoto, Fuminori Tokunaga, Megumi Onishi, Akira Myoui, Hideki Yoshikawa, Kazuhiro Iwai Masato Tomonaga, Nobuyuki Hashimoto, Fuminori Tokunaga, Megumi Onishi, Akira Myoui, Hideki Yoshikawa, Kazuhiro Iwai Activation of nuclear factor-kappa B by linear ubiquitin chain assembly complex contributes to lung metastasis of osteosarcoma cells Activation of nuclear factor-kappa B by linear ubiquitin chain assembly complex contributes to lung metastasis of osteosarcoma cells Activation of nuclear factor-kappa B by linear ubiquitin chain assembly complex contributes to lung metastasis of osteosarcoma cells INTERNATIONAL JOURNAL OF ONCOLOGY, 40, 2, 409-417 INTERNATIONAL JOURNAL OF ONCOLOGY, 40, 2, 409-417 INTERNATIONAL JOURNAL OF ONCOLOGY, 40, 2, 409-417 2012/02 Refereed English Research paper(scientific journal) Disclose to all
K. Iwai K. Iwai K. Iwai Synthesis and analysis of linear ubiquitin chains. Synthesis and analysis of linear ubiquitin chains. Synthesis and analysis of linear ubiquitin chains. Methods in molecular biology (Clifton, N.J.), 832, 229-238 Methods in molecular biology (Clifton, N.J.), 832, 229-238 Methods in molecular biology (Clifton, N.J.), 832, 229-238 2012 Refereed English Disclose to all
Sato Y, Fujita H, Yoshikawa A, Yamashita M, Yamagata A, Kaiser SE, Iwai K, Fukai S Sato Y, Fujita H, Yoshikawa A, Yamashita M, Yamagata A, Kaiser SE, Iwai K, Fukai S Sato Y, Fujita H, Yoshikawa A, Yamashita M, Yamagata A, Kaiser SE, Iwai K, Fukai S Specific recognition of linear ubiquitin chains by the Npl4 zinc finger (NZF) domain of the HOIL-1L subunit of the linear ubiquitin chain assembly complex. Specific recognition of linear ubiquitin chains by the Npl4 zinc finger (NZF) domain of the HOIL-1L subunit of the linear ubiquitin chain assembly complex. Specific recognition of linear ubiquitin chains by the Npl4 zinc finger (NZF) domain of the HOIL-1L subunit of the linear ubiquitin chain assembly complex. Proceedings of the National Academy of Sciences of the United States of America, 108, 51, 20520-20525 Proceedings of the National Academy of Sciences of the United States of America, 108, 51, 20520-20525 Proceedings of the National Academy of Sciences of the United States of America, 108, 51, 20520-20525 2011/12 Refereed Disclose to all
Jixiao Niu, Yuling Shi, Kazuhiro Iwai, Zhao-Hui Wu Jixiao Niu, Yuling Shi, Kazuhiro Iwai, Zhao-Hui Wu Jixiao Niu, Yuling Shi, Kazuhiro Iwai, Zhao-Hui Wu LUBAC regulates NF-kappa B activation upon genotoxic stress by promoting linear ubiquitination of NEMO LUBAC regulates NF-kappa B activation upon genotoxic stress by promoting linear ubiquitination of NEMO LUBAC regulates NF-kappa B activation upon genotoxic stress by promoting linear ubiquitination of NEMO EMBO JOURNAL, 30, 18, 3741-3753 EMBO JOURNAL, 30, 18, 3741-3753 EMBO JOURNAL, 30, 18, 3741-3753 2011/09 Refereed English Research paper(scientific journal) Disclose to all
Toshiro Moroishi, Masaaki Nishiyama, Yukiko Takeda, Kazuhiro Iwai, Keiichi I. Nakayama Toshiro Moroishi, Masaaki Nishiyama, Yukiko Takeda, Kazuhiro Iwai, Keiichi I. Nakayama Toshiro Moroishi, Masaaki Nishiyama, Yukiko Takeda, Kazuhiro Iwai, Keiichi I. Nakayama The FBXL5-IRP2 Axis Is Integral to Control of Iron Metabolism In Vivo The FBXL5-IRP2 Axis Is Integral to Control of Iron Metabolism In Vivo The FBXL5-IRP2 Axis Is Integral to Control of Iron Metabolism In Vivo CELL METABOLISM, 14, 3, 339-351 CELL METABOLISM, 14, 3, 339-351 CELL METABOLISM, 14, 3, 339-351 2011/09 Refereed English Research paper(scientific journal) Disclose to all
Kazuhiro Iwai Kazuhiro Iwai Kazuhiro Iwai Linear polyubiquitin chains A new modifier involved in NF kappa B activation and chronic inflammation including dermatitis Linear polyubiquitin chains A new modifier involved in NF kappa B activation and chronic inflammation including dermatitis Linear polyubiquitin chains A new modifier involved in NF kappa B activation and chronic inflammation including dermatitis CELL CYCLE, 10, 18, 3095-3104 CELL CYCLE, 10, 18, 3095-3104 CELL CYCLE, 10, 18, 3095-3104 2011/09 Refereed English Research paper(scientific journal) Disclose to all
Masaki Takatsuka, Mayuko Osada-Oka, Eisuke F. Satoh, Kengo Kitadokoro, Yukiko Nishiuchi, Mamiko Niki, Masayasu Inoue, Kazuhiro Iwai, Tetsuo Arakawa, Yoshihiro Shimoji, Hisashi Ogura, Kazuo Kobayashi, Anura Rambukkana, Sohkichi Matsumoto Masaki Takatsuka, Mayuko Osada-Oka, Eisuke F. Satoh, Kengo Kitadokoro, Yukiko Nishiuchi, Mamiko Niki, Masayasu Inoue, Kazuhiro Iwai, Tetsuo Arakawa, Yoshihiro Shimoji, Hisashi Ogura, Kazuo Kobayashi, Anura Rambukkana, Sohkichi Matsumoto Masaki Takatsuka, Mayuko Osada-Oka, Eisuke F. Satoh, Kengo Kitadokoro, Yukiko Nishiuchi, Mamiko Niki, Masayasu Inoue, Kazuhiro Iwai, Tetsuo Arakawa, Yoshihiro Shimoji, Hisashi Ogura, Kazuo Kobayashi, Anura Rambukkana, Sohkichi Matsumoto A Histone-Like Protein of Mycobacteria Possesses Ferritin Superfamily Protein-Like Activity and Protects against DNA Damage by Fenton Reaction A Histone-Like Protein of Mycobacteria Possesses Ferritin Superfamily Protein-Like Activity and Protects against DNA Damage by Fenton Reaction A Histone-Like Protein of Mycobacteria Possesses Ferritin Superfamily Protein-Like Activity and Protects against DNA Damage by Fenton Reaction PLOS ONE, 6, 6 PLOS ONE, 6, 6 PLOS ONE, 6, 6 2011/06 Refereed English Research paper(scientific journal) Disclose to all
Takeshi Asano, Masaaki Komatsu, Yuko Yamaguchi-Iwai, Fuyuki Ishikawa, Noboru Mizushima, Kazuhiro Iwai Takeshi Asano, Masaaki Komatsu, Yuko Yamaguchi-Iwai, Fuyuki Ishikawa, Noboru Mizushima, Kazuhiro Iwai Takeshi Asano, Masaaki Komatsu, Yuko Yamaguchi-Iwai, Fuyuki Ishikawa, Noboru Mizushima, Kazuhiro Iwai Distinct Mechanisms of Ferritin Delivery to Lysosomes in Iron-Depleted and Iron-Replete Cells Distinct Mechanisms of Ferritin Delivery to Lysosomes in Iron-Depleted and Iron-Replete Cells Distinct Mechanisms of Ferritin Delivery to Lysosomes in Iron-Depleted and Iron-Replete Cells MOLECULAR AND CELLULAR BIOLOGY, 31, 10, 2040-2052 MOLECULAR AND CELLULAR BIOLOGY, 31, 10, 2040-2052 MOLECULAR AND CELLULAR BIOLOGY, 31, 10, 2040-2052 2011/05 Refereed English Research paper(scientific journal) Disclose to all
Fuminori Tokunaga, Tomoko Nakagawa, Masaki Nakahara, Yasushi Saeki, Masami Taniguchi, Shin-ichi Sakata, Keiji Tanaka, Hiroyasu Nakano, Kazuhiro Iwai Fuminori Tokunaga, Tomoko Nakagawa, Masaki Nakahara, Yasushi Saeki, Masami Taniguchi, Shin-ichi Sakata, Keiji Tanaka, Hiroyasu Nakano, Kazuhiro Iwai Fuminori Tokunaga, Tomoko Nakagawa, Masaki Nakahara, Yasushi Saeki, Masami Taniguchi, Shin-ichi Sakata, Keiji Tanaka, Hiroyasu Nakano, Kazuhiro Iwai SHARPIN is a component of the NF-kappa B-activating linear ubiquitin chain assembly complex SHARPIN is a component of the NF-kappa B-activating linear ubiquitin chain assembly complex SHARPIN is a component of the NF-kappa B-activating linear ubiquitin chain assembly complex NATURE, 471, 7340, 633-U113 NATURE, 471, 7340, 633-U113 NATURE, 471, 7340, 633-U113 2011/03 Refereed English Research paper(scientific journal) Disclose to all
Fumiyo Ikeda, Yonathan Lissanu Deribe, Sigrid S. Skanland, Benjamin Stieglitz, Caroline Grabbe, Mirita Franz-Wachtel, Sjoerd J. L. van Wijk, Panchali Goswami, Vanja Nagy, Janos Terzic, Fuminori Tokunaga, Ariadne Androulidaki, Tomoko Nakagawa, Manolis Pasparakis, Kazuhiro Iwai, John P. Sundberg, Liliana Schaefer, Katrin Rittinger, Boris Macek, Ivan Dikic Fumiyo Ikeda, Yonathan Lissanu Deribe, Sigrid S. Skanland, Benjamin Stieglitz, Caroline Grabbe, Mirita Franz-Wachtel, Sjoerd J. L. van Wijk, Panchali Goswami, Vanja Nagy, Janos Terzic, Fuminori Tokunaga, Ariadne Androulidaki, Tomoko Nakagawa, Manolis Pasparakis, Kazuhiro Iwai, John P. Sundberg, Liliana Schaefer, Katrin Rittinger, Boris Macek, Ivan Dikic Fumiyo Ikeda, Yonathan Lissanu Deribe, Sigrid S. Skanland, Benjamin Stieglitz, Caroline Grabbe, Mirita Franz-Wachtel, Sjoerd J. L. van Wijk, Panchali Goswami, Vanja Nagy, Janos Terzic, Fuminori Tokunaga, Ariadne Androulidaki, Tomoko Nakagawa, Manolis Pasparakis, Kazuhiro Iwai, John P. Sundberg, Liliana Schaefer, Katrin Rittinger, Boris Macek, Ivan Dikic SHARPIN forms a linear ubiquitin ligase complex regulating NF-kappa B activity and apoptosis SHARPIN forms a linear ubiquitin ligase complex regulating NF-kappa B activity and apoptosis SHARPIN forms a linear ubiquitin ligase complex regulating NF-kappa B activity and apoptosis NATURE, 471, 7340, 637-U120 NATURE, 471, 7340, 637-U120 NATURE, 471, 7340, 637-U120 2011/03 Refereed English Research paper(scientific journal) Disclose to all
Haruto Ishikawa, Megumi Nakagaki, Ai Bamba, Takeshi Uchida, Hiroshi Hori, Mark R. O'Brian, Kazuhiro Iwai, Koichiro Ishimori Haruto Ishikawa, Megumi Nakagaki, Ai Bamba, Takeshi Uchida, Hiroshi Hori, Mark R. O'Brian, Kazuhiro Iwai, Koichiro Ishimori Haruto Ishikawa, Megumi Nakagaki, Ai Bamba, Takeshi Uchida, Hiroshi Hori, Mark R. O'Brian, Kazuhiro Iwai, Koichiro Ishimori Unusual Heme Binding in the Bacterial Iron Response Regulator Protein: Spectral Characterization of Heme Binding to the Heme Regulatory Motif Unusual Heme Binding in the Bacterial Iron Response Regulator Protein: Spectral Characterization of Heme Binding to the Heme Regulatory Motif Unusual Heme Binding in the Bacterial Iron Response Regulator Protein: Spectral Characterization of Heme Binding to the Heme Regulatory Motif BIOCHEMISTRY, 50, 6, 1016-1022 BIOCHEMISTRY, 50, 6, 1016-1022 BIOCHEMISTRY, 50, 6, 1016-1022 2011/02 Refereed English Research paper(scientific journal) Disclose to all
Kyung-Soo Inn, Michaela U. Gack, Fuminori Tokunaga, Mude Shi, Lai-Yee Wong, Kazuhiro Iwai, Jae U. Jung Kyung-Soo Inn, Michaela U. Gack, Fuminori Tokunaga, Mude Shi, Lai-Yee Wong, Kazuhiro Iwai, Jae U. Jung Kyung-Soo Inn, Michaela U. Gack, Fuminori Tokunaga, Mude Shi, Lai-Yee Wong, Kazuhiro Iwai, Jae U. Jung Linear Ubiquitin Assembly Complex Negatively Regulates RIG-I- and TRIM25-Mediated Type I Interferon Induction Linear Ubiquitin Assembly Complex Negatively Regulates RIG-I- and TRIM25-Mediated Type I Interferon Induction Linear Ubiquitin Assembly Complex Negatively Regulates RIG-I- and TRIM25-Mediated Type I Interferon Induction MOLECULAR CELL, 41, 3, 354-365 MOLECULAR CELL, 41, 3, 354-365 MOLECULAR CELL, 41, 3, 354-365 2011/02 Refereed English Research paper(scientific journal) Disclose to all
Kana Shimada, Makio Saeki, Hiroshi Egusa, Sho Fukuyasu, Yoshiaki Yura, Kazuhiro Iwai, Yoshinori Kamisaki Kana Shimada, Makio Saeki, Hiroshi Egusa, Sho Fukuyasu, Yoshiaki Yura, Kazuhiro Iwai, Yoshinori Kamisaki Kana Shimada, Makio Saeki, Hiroshi Egusa, Sho Fukuyasu, Yoshiaki Yura, Kazuhiro Iwai, Yoshinori Kamisaki RPAP3 enhances cytotoxicity of doxorubicin by impairing NF-kappa B pathway RPAP3 enhances cytotoxicity of doxorubicin by impairing NF-kappa B pathway RPAP3 enhances cytotoxicity of doxorubicin by impairing NF-kappa B pathway BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 404, 4, 910-914 BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 404, 4, 910-914 BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 404, 4, 910-914 2011/01 Refereed English Research paper(scientific journal) Disclose to all
Hanako Morikawa, Minsoo Kim, Hitomi Mimuro, Claire Punginelli, Tomohiro Koyama, Shinya Nagai, Atsushi Miyawaki, Kazuhiro Iwai, Chihiro Sasakawa Hanako Morikawa, Minsoo Kim, Hitomi Mimuro, Claire Punginelli, Tomohiro Koyama, Shinya Nagai, Atsushi Miyawaki, Kazuhiro Iwai, Chihiro Sasakawa Hanako Morikawa, Minsoo Kim, Hitomi Mimuro, Claire Punginelli, Tomohiro Koyama, Shinya Nagai, Atsushi Miyawaki, Kazuhiro Iwai, Chihiro Sasakawa The bacterial effector Cif interferes with SCF ubiquitin ligase function by inhibiting deneddylation of Cullin1 The bacterial effector Cif interferes with SCF ubiquitin ligase function by inhibiting deneddylation of Cullin1 The bacterial effector Cif interferes with SCF ubiquitin ligase function by inhibiting deneddylation of Cullin1 BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 401, 2, 268-274 BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 401, 2, 268-274 BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 401, 2, 268-274 2010/10 Refereed English Research paper(scientific journal) Disclose to all
Taichi Kumanomidou, Tomomi Nakagawa, Tsunehiro Mizushima, Atsuo Suzuki, Fuminori Tokunaga, Kazuhiro Iwai, Yukiko Yoshida, Keiji Tanaka, Takashi Yamane Taichi Kumanomidou, Tomomi Nakagawa, Tsunehiro Mizushima, Atsuo Suzuki, Fuminori Tokunaga, Kazuhiro Iwai, Yukiko Yoshida, Keiji Tanaka, Takashi Yamane Taichi Kumanomidou, Tomomi Nakagawa, Tsunehiro Mizushima, Atsuo Suzuki, Fuminori Tokunaga, Kazuhiro Iwai, Yukiko Yoshida, Keiji Tanaka, Takashi Yamane Crystallization and preliminary X-ray characterization of the Skp1-Fbg3 complex Crystallization and preliminary X-ray characterization of the Skp1-Fbg3 complex Crystallization and preliminary X-ray characterization of the Skp1-Fbg3 complex ACTA CRYSTALLOGRAPHICA SECTION F-STRUCTURAL BIOLOGY AND CRYSTALLIZATION COMMUNICATIONS, 66, 1, 95-98 ACTA CRYSTALLOGRAPHICA SECTION F-STRUCTURAL BIOLOGY AND CRYSTALLIZATION COMMUNICATIONS, 66, 1, 95-98 ACTA CRYSTALLOGRAPHICA SECTION F-STRUCTURAL BIOLOGY AND CRYSTALLIZATION COMMUNICATIONS, 66, 1, 95-98 2010/01 Refereed English Research paper(scientific journal) Disclose to all
Kazuhiro Iwai, Fuminori Tokunaga K. Iwai, F. Tokunaga Kazuhiro Iwai, Fuminori Tokunaga Linear polyubiquitination: a new regulator of NF-kappa B activation Linear polyubiquitination: A new regulator of NF-κB activation Linear polyubiquitination: a new regulator of NF-kappa B activation EMBO REPORTS, 10, 7, 706-713 EMBO Reports, 10, 7, 706-713 EMBO REPORTS, 10, 7, 706-713 2009/07 Refereed English Disclose to all
Tokunaga F, Iwai K Tokunaga F, Iwai K Tokunaga F, Iwai K [Involvement of LUBAC-mediated linear polyubiquitination of NEMO in NF-kappaB activation]. [Involvement of LUBAC-mediated linear polyubiquitination of NEMO in NF-kappaB activation]. [Involvement of LUBAC-mediated linear polyubiquitination of NEMO in NF-kappaB activation]. Tanpakushitsu kakusan koso. Protein, nucleic acid, enzyme, 54, 5, 635-642 Tanpakushitsu kakusan koso. Protein, nucleic acid, enzyme, 54, 5, 635-642 Tanpakushitsu kakusan koso. Protein, nucleic acid, enzyme, 54, 5, 635-642 2009/04 Refereed Disclose to all
Kiyo-aki Ishii, Toshio Fumoto, Kazuhiro Iwai, Sunao Takeshita, Masako Ito, Nobuyuki Shimohata, Hiroyuki Aburatani, Shigeru Taketani, Christopher J. Lelliott, Antonio Vidal-Puig, Kyoji Ikeda Kiyo-aki Ishii, Toshio Fumoto, Kazuhiro Iwai, Sunao Takeshita, Masako Ito, Nobuyuki Shimohata, Hiroyuki Aburatani, Shigeru Taketani, Christopher J. Lelliott, Antonio Vidal-Puig, Kyoji Ikeda Kiyo-aki Ishii, Toshio Fumoto, Kazuhiro Iwai, Sunao Takeshita, Masako Ito, Nobuyuki Shimohata, Hiroyuki Aburatani, Shigeru Taketani, Christopher J. Lelliott, Antonio Vidal-Puig, Kyoji Ikeda Coordination of PGC-1 beta and iron uptake in mitochondrial biogenesis and osteoclast activation Coordination of PGC-1 beta and iron uptake in mitochondrial biogenesis and osteoclast activation Coordination of PGC-1 beta and iron uptake in mitochondrial biogenesis and osteoclast activation NATURE MEDICINE, 15, 3, 259-266 NATURE MEDICINE, 15, 3, 259-266 NATURE MEDICINE, 15, 3, 259-266 2009/03 Refereed English Research paper(scientific journal) Disclose to all
Fuminori Tokunaga, Shin-ichi Sakata, Yasushi Saeki, Yoshinori Satomi, Takayoshi Kirisako, Kiyoko Kamei, Tomoko Nakagawa, Michiko Kato, Shigeo Murata, Shoji Yamaoka, Masahiro Yamamoto, Shizuo Akira, Toshifumi Takao, Keiji Tanaka, Kazuhiro Iwai Fuminori Tokunaga, Shin-ichi Sakata, Yasushi Saeki, Yoshinori Satomi, Takayoshi Kirisako, Kiyoko Kamei, Tomoko Nakagawa, Michiko Kato, Shigeo Murata, Shoji Yamaoka, Masahiro Yamamoto, Shizuo Akira, Toshifumi Takao, Keiji Tanaka, Kazuhiro Iwai Fuminori Tokunaga, Shin-ichi Sakata, Yasushi Saeki, Yoshinori Satomi, Takayoshi Kirisako, Kiyoko Kamei, Tomoko Nakagawa, Michiko Kato, Shigeo Murata, Shoji Yamaoka, Masahiro Yamamoto, Shizuo Akira, Toshifumi Takao, Keiji Tanaka, Kazuhiro Iwai Involvement of linear polyubiquitylation of NEMO in NF-kappa B activation Involvement of linear polyubiquitylation of NEMO in NF-kappa B activation Involvement of linear polyubiquitylation of NEMO in NF-kappa B activation NATURE CELL BIOLOGY, 11, 2, 123-U40 NATURE CELL BIOLOGY, 11, 2, 123-U40 NATURE CELL BIOLOGY, 11, 2, 123-U40 2009/02 Refereed English Research paper(scientific journal) Disclose to all
Taisuke Izumi, Akifumi Takaori-Kondo, Kotaro Shirakawa, Hiroaki Higashitsuji, Katsuhiko Itoh, Katsuhiro Io, Masashi Matsui, Kazuhiro Iwai, Hiroshi Kondoh, Toshihiro Sato, Mitsunori Tomonaga, Satoru Ikeda, Hirofumi Akari, Yoshio Koyanagi, Jun Fujita, Takashi Uchiyama Taisuke Izumi, Akifumi Takaori-Kondo, Kotaro Shirakawa, Hiroaki Higashitsuji, Katsuhiko Itoh, Katsuhiro Io, Masashi Matsui, Kazuhiro Iwai, Hiroshi Kondoh, Toshihiro Sato, Mitsunori Tomonaga, Satoru Ikeda, Hirofumi Akari, Yoshio Koyanagi, Jun Fujita, Takashi Uchiyama Taisuke Izumi, Akifumi Takaori-Kondo, Kotaro Shirakawa, Hiroaki Higashitsuji, Katsuhiko Itoh, Katsuhiro Io, Masashi Matsui, Kazuhiro Iwai, Hiroshi Kondoh, Toshihiro Sato, Mitsunori Tomonaga, Satoru Ikeda, Hirofumi Akari, Yoshio Koyanagi, Jun Fujita, Takashi Uchiyama MDM2 is a novel E3 ligase for HIV-1 Vif MDM2 is a novel E3 ligase for HIV-1 Vif MDM2 is a novel E3 ligase for HIV-1 Vif RETROVIROLOGY, 6 RETROVIROLOGY, 6 RETROVIROLOGY, 6 2009/01 Refereed English Research paper(scientific journal) Disclose to all
Yusuke Sato, Azusa Yoshikawa, Atsushi Yamagata, Hisatoshi Mimura, Masami Yamashita, Kayoko Ookata, Osamu Nureki, Kazuhiro Iwai, Masayuki Komada, Shuya Fukai Yusuke Sato, Azusa Yoshikawa, Atsushi Yamagata, Hisatoshi Mimura, Masami Yamashita, Kayoko Ookata, Osamu Nureki, Kazuhiro Iwai, Masayuki Komada, Shuya Fukai Yusuke Sato, Azusa Yoshikawa, Atsushi Yamagata, Hisatoshi Mimura, Masami Yamashita, Kayoko Ookata, Osamu Nureki, Kazuhiro Iwai, Masayuki Komada, Shuya Fukai Structural basis for specific cleavage of Lys 63-linked polyubiquitin chains (vol 455, pg 358, 2008) Structural basis for specific cleavage of Lys 63-linked polyubiquitin chains (vol 455, pg 358, 2008) Structural basis for specific cleavage of Lys 63-linked polyubiquitin chains (vol 455, pg 358, 2008) NATURE, 456, 7219, 274-274 NATURE, 456, 7219, 274-274 NATURE, 456, 7219, 274-274 2008/11 Refereed English Disclose to all
Yusuke Sato, Azusa Yoshikawa, Atsushi Yamagata, Hisatoshi Mimura, Masami Yamashita, Kayoko Ookata, Osamu Nureki, Kazuhiro Iwai, Masayuki Komada, Shuya Fukai Yusuke Sato, Azusa Yoshikawa, Atsushi Yamagata, Hisatoshi Mimura, Masami Yamashita, Kayoko Ookata, Osamu Nureki, Kazuhiro Iwai, Masayuki Komada, Shuya Fukai Yusuke Sato, Azusa Yoshikawa, Atsushi Yamagata, Hisatoshi Mimura, Masami Yamashita, Kayoko Ookata, Osamu Nureki, Kazuhiro Iwai, Masayuki Komada, Shuya Fukai Structural basis for specific cleavage of Lys 63-linked polyubiquitin chains Structural basis for specific cleavage of Lys 63-linked polyubiquitin chains Structural basis for specific cleavage of Lys 63-linked polyubiquitin chains NATURE, 455, 7211, 358-U19 NATURE, 455, 7211, 358-U19 NATURE, 455, 7211, 358-U19 2008/09 Refereed English Research paper(scientific journal) Disclose to all
Yasuhiro Miyauchi, Michiko Kato, Fuminori Tokunaga, Kazuhiro Iwai Yasuhiro Miyauchi, Michiko Kato, Fuminori Tokunaga, Kazuhiro Iwai Yasuhiro Miyauchi, Michiko Kato, Fuminori Tokunaga, Kazuhiro Iwai The COP9/signalosome increases the efficiency of von hippel-lindau protein ubiquitin ligase-mediated hypoxia-inducible factor-alpha ubiquitination The COP9/signalosome increases the efficiency of von hippel-lindau protein ubiquitin ligase-mediated hypoxia-inducible factor-alpha ubiquitination The COP9/signalosome increases the efficiency of von hippel-lindau protein ubiquitin ligase-mediated hypoxia-inducible factor-alpha ubiquitination JOURNAL OF BIOLOGICAL CHEMISTRY, 283, 24, 16622-16631 JOURNAL OF BIOLOGICAL CHEMISTRY, 283, 24, 16622-16631 JOURNAL OF BIOLOGICAL CHEMISTRY, 283, 24, 16622-16631 2008/06 Refereed English Research paper(scientific journal) Disclose to all
Guofei Zhou, Laura A. Dada, Navdeep S. Chandel, Kazuhiro Iwai, Emilia Lecuona, Aaron Ciechanover, Jacob I. Sznajder Guofei Zhou, Laura A. Dada, Navdeep S. Chandel, Kazuhiro Iwai, Emilia Lecuona, Aaron Ciechanover, Jacob I. Sznajder Guofei Zhou, Laura A. Dada, Navdeep S. Chandel, Kazuhiro Iwai, Emilia Lecuona, Aaron Ciechanover, Jacob I. Sznajder Hypoxia-mediated Na-K-ATPase degradation requires von Hippel Lindau protein Hypoxia-mediated Na-K-ATPase degradation requires von Hippel Lindau protein Hypoxia-mediated Na-K-ATPase degradation requires von Hippel Lindau protein FASEB JOURNAL, 22, 5, 1335-1342 FASEB JOURNAL, 22, 5, 1335-1342 FASEB JOURNAL, 22, 5, 1335-1342 2008/05 Refereed English Research paper(scientific journal) Disclose to all
Daisuke Morito, Kazuyoshi Hirao, Yukako Oda, Nobuko Hosokawa, Fuminori Tokunaga, Douglas M. Cyr, Keiji Tanaka, Kazuhiro Iwai, Kazuhiro Nagata Daisuke Morito, Kazuyoshi Hirao, Yukako Oda, Nobuko Hosokawa, Fuminori Tokunaga, Douglas M. Cyr, Keiji Tanaka, Kazuhiro Iwai, Kazuhiro Nagata Daisuke Morito, Kazuyoshi Hirao, Yukako Oda, Nobuko Hosokawa, Fuminori Tokunaga, Douglas M. Cyr, Keiji Tanaka, Kazuhiro Iwai, Kazuhiro Nagata Gp78 cooperates with RMA1 in endoplasmic reticulum-associated degradation of CFTR Delta F508 Gp78 cooperates with RMA1 in endoplasmic reticulum-associated degradation of CFTR Delta F508 Gp78 cooperates with RMA1 in endoplasmic reticulum-associated degradation of CFTR Delta F508 MOLECULAR BIOLOGY OF THE CELL, 19, 4, 1328-1336 MOLECULAR BIOLOGY OF THE CELL, 19, 4, 1328-1336 MOLECULAR BIOLOGY OF THE CELL, 19, 4, 1328-1336 2008/04 Refereed English Research paper(scientific journal) Disclose to all
Hajime Yano, Itaru Kobayashi, Yasuhito Onodera, Frederic Luton, Michel Franco, Yuichi Mazaki, Shigeru Hashimoto, Kazuhiro Iwai, Ze'ev Ronai, Hisataka Sabe Hajime Yano, Itaru Kobayashi, Yasuhito Onodera, Frederic Luton, Michel Franco, Yuichi Mazaki, Shigeru Hashimoto, Kazuhiro Iwai, Ze'ev Ronai, Hisataka Sabe Hajime Yano, Itaru Kobayashi, Yasuhito Onodera, Frederic Luton, Michel Franco, Yuichi Mazaki, Shigeru Hashimoto, Kazuhiro Iwai, Ze'ev Ronai, Hisataka Sabe Fbx8 makes Arf6 refractory to function via ubiquitination Fbx8 makes Arf6 refractory to function via ubiquitination Fbx8 makes Arf6 refractory to function via ubiquitination MOLECULAR BIOLOGY OF THE CELL, 19, 3, 822-832 MOLECULAR BIOLOGY OF THE CELL, 19, 3, 822-832 MOLECULAR BIOLOGY OF THE CELL, 19, 3, 822-832 2008/03 Refereed English Research paper(scientific journal) Disclose to all
Nitzan Shabek, Kazuhiro Iwai, Aaron Ciechanover Nitzan Shabek, Kazuhiro Iwai, Aaron Ciechanover Nitzan Shabek, Kazuhiro Iwai, Aaron Ciechanover Ubiquitin is degraded by the ubiquitin system as a monomer and as part of its conjugated target Ubiquitin is degraded by the ubiquitin system as a monomer and as part of its conjugated target Ubiquitin is degraded by the ubiquitin system as a monomer and as part of its conjugated target BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 363, 2, 425-431 BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 363, 2, 425-431 BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 363, 2, 425-431 2007/11 Refereed English Research paper(scientific journal) Disclose to all
Kazuchika Nishitsuji, Takami Tomiyama, Kenichi Ishibashi, Fuyuki Kametani, Kazuharu Ozawa, Ryota Okada, Marion L. Maat-Schieman, Raymund A. C. Roos, Kazuhiro Iwai, Hiroshi Mori Kazuchika Nishitsuji, Takami Tomiyama, Kenichi Ishibashi, Fuyuki Kametani, Kazuharu Ozawa, Ryota Okada, Marion L. Maat-Schieman, Raymund A. C. Roos, Kazuhiro Iwai, Hiroshi Mori Kazuchika Nishitsuji, Takami Tomiyama, Kenichi Ishibashi, Fuyuki Kametani, Kazuharu Ozawa, Ryota Okada, Marion L. Maat-Schieman, Raymund A. C. Roos, Kazuhiro Iwai, Hiroshi Mori Cerebral vascular accumulation of dutch-type A beta 42, but not wild-type A beta 42, in hereditary cerebral hemorrhage with amyloidosis, Dutch type Cerebral vascular accumulation of dutch-type A beta 42, but not wild-type A beta 42, in hereditary cerebral hemorrhage with amyloidosis, Dutch type Cerebral vascular accumulation of dutch-type A beta 42, but not wild-type A beta 42, in hereditary cerebral hemorrhage with amyloidosis, Dutch type JOURNAL OF NEUROSCIENCE RESEARCH, 85, 13, 2917-2923 JOURNAL OF NEUROSCIENCE RESEARCH, 85, 13, 2917-2923 JOURNAL OF NEUROSCIENCE RESEARCH, 85, 13, 2917-2923 2007/10 Refereed English Research paper(scientific journal) Disclose to all
Yukari Zenke-Kawasaki, Yoshihiro Dohi, Yasutake Katoh, Tsuyoshi Ikura, Masae Ikura, Toshimasa Asahara, Furninori Tokunaga, Kazuhiro Iwai, Kazuhiko Igarashi Yukari Zenke-Kawasaki, Yoshihiro Dohi, Yasutake Katoh, Tsuyoshi Ikura, Masae Ikura, Toshimasa Asahara, Furninori Tokunaga, Kazuhiro Iwai, Kazuhiko Igarashi Yukari Zenke-Kawasaki, Yoshihiro Dohi, Yasutake Katoh, Tsuyoshi Ikura, Masae Ikura, Toshimasa Asahara, Furninori Tokunaga, Kazuhiro Iwai, Kazuhiko Igarashi Heme induces ubiquitination and degradation of the transcription factor bach1 Heme induces ubiquitination and degradation of the transcription factor bach1 Heme induces ubiquitination and degradation of the transcription factor bach1 MOLECULAR AND CELLULAR BIOLOGY, 27, 19, 6962-6971 MOLECULAR AND CELLULAR BIOLOGY, 27, 19, 6962-6971 MOLECULAR AND CELLULAR BIOLOGY, 27, 19, 6962-6971 2007/10 Refereed English Research paper(scientific journal) Disclose to all
Ryo Ueta, Naoko Fujiwara, Kazuhiro Iwai, Yuko Yamaguchi-Iwai Ryo Ueta, Naoko Fujiwara, Kazuhiro Iwai, Yuko Yamaguchi-Iwai Ryo Ueta, Naoko Fujiwara, Kazuhiro Iwai, Yuko Yamaguchi-Iwai Mechanism underlying the iron-dependent nuclear export of the iron-responsive transcription factor Aft1p in Saccharomyces cerevisiae Mechanism underlying the iron-dependent nuclear export of the iron-responsive transcription factor Aft1p in Saccharomyces cerevisiae Mechanism underlying the iron-dependent nuclear export of the iron-responsive transcription factor Aft1p in Saccharomyces cerevisiae MOLECULAR BIOLOGY OF THE CELL, 18, 8, 2980-2990 MOLECULAR BIOLOGY OF THE CELL, 18, 8, 2980-2990 MOLECULAR BIOLOGY OF THE CELL, 18, 8, 2980-2990 2007/08 Refereed English Research paper(scientific journal) Disclose to all
Yukiko Yoshida, Arisa Murakami, Kazuhiro Iwai, Keiji Tanaka Yukiko Yoshida, Arisa Murakami, Kazuhiro Iwai, Keiji Tanaka Yukiko Yoshida, Arisa Murakami, Kazuhiro Iwai, Keiji Tanaka A neural-specific F-box protein Fbs1 functions as a chaperone suppressing glycoprotein aggregation A neural-specific F-box protein Fbs1 functions as a chaperone suppressing glycoprotein aggregation A neural-specific F-box protein Fbs1 functions as a chaperone suppressing glycoprotein aggregation JOURNAL OF BIOLOGICAL CHEMISTRY, 282, 10, 7137-7144 JOURNAL OF BIOLOGICAL CHEMISTRY, 282, 10, 7137-7144 JOURNAL OF BIOLOGICAL CHEMISTRY, 282, 10, 7137-7144 2007/03 Refereed English Research paper(scientific journal) Disclose to all
Eri Sakata, Yoshiki Yamaguchi, Yasuhiro Miyauchi, Kazuhiro Iwai, Tomoki Chiba, Yasushi Saeki, Noriyuki Matsuda, Keiji Tanaka, Koichi Kato Eri Sakata, Yoshiki Yamaguchi, Yasuhiro Miyauchi, Kazuhiro Iwai, Tomoki Chiba, Yasushi Saeki, Noriyuki Matsuda, Keiji Tanaka, Koichi Kato Eri Sakata, Yoshiki Yamaguchi, Yasuhiro Miyauchi, Kazuhiro Iwai, Tomoki Chiba, Yasushi Saeki, Noriyuki Matsuda, Keiji Tanaka, Koichi Kato Direct interactions between NEDD8 and ubiquitin E2 conjugating enzymes upregulate cullin-based E3 ligase activity Direct interactions between NEDD8 and ubiquitin E2 conjugating enzymes upregulate cullin-based E3 ligase activity Direct interactions between NEDD8 and ubiquitin E2 conjugating enzymes upregulate cullin-based E3 ligase activity NATURE STRUCTURAL & MOLECULAR BIOLOGY, 14, 2, 167-168 NATURE STRUCTURAL & MOLECULAR BIOLOGY, 14, 2, 167-168 NATURE STRUCTURAL & MOLECULAR BIOLOGY, 14, 2, 167-168 2007/02 Refereed English Research paper(scientific journal) Disclose to all
Munehiro Nakamura, Fuminori Tokunaga, Shin-ichi Sakata, Kazuhiro Iwai Munehiro Nakamura, Fuminori Tokunaga, Shin-ichi Sakata, Kazuhiro Iwai Munehiro Nakamura, Fuminori Tokunaga, Shin-ichi Sakata, Kazuhiro Iwai Mutual regulation of conventional protein kinase C and a ubiquitin ligase complex Mutual regulation of conventional protein kinase C and a ubiquitin ligase complex Mutual regulation of conventional protein kinase C and a ubiquitin ligase complex BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 351, 2, 340-347 BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 351, 2, 340-347 BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 351, 2, 340-347 2006/12 Refereed English Research paper(scientific journal) Disclose to all
Olga N. Burchak, Michel Jaquinod, Claire Cottin, Laurent Mugherli, Kazuhiro Iwai, Francois Chatelain, Maxim Y. Balakirev Olga N. Burchak, Michel Jaquinod, Claire Cottin, Laurent Mugherli, Kazuhiro Iwai, Francois Chatelain, Maxim Y. Balakirev Olga N. Burchak, Michel Jaquinod, Claire Cottin, Laurent Mugherli, Kazuhiro Iwai, Francois Chatelain, Maxim Y. Balakirev Chemoenzymatic ubiquitination of artificial substrates Chemoenzymatic ubiquitination of artificial substrates Chemoenzymatic ubiquitination of artificial substrates CHEMBIOCHEM, 7, 11, 1667-+ CHEMBIOCHEM, 7, 11, 1667-+ CHEMBIOCHEM, 7, 11, 1667-+ 2006/11 Refereed English Research paper(scientific journal) Disclose to all
Takayoshi Kirisako, Kiyoko Kamei, Shigeo Murata, Michiko Kato, Hiromi Fukumoto, Masato Kanie, Soichi Sano, Fuminori Tokunaga, Keiji Tanaka, Kazuhiro Iwai Takayoshi Kirisako, Kiyoko Kamei, Shigeo Murata, Michiko Kato, Hiromi Fukumoto, Masato Kanie, Soichi Sano, Fuminori Tokunaga, Keiji Tanaka, Kazuhiro Iwai Takayoshi Kirisako, Kiyoko Kamei, Shigeo Murata, Michiko Kato, Hiromi Fukumoto, Masato Kanie, Soichi Sano, Fuminori Tokunaga, Keiji Tanaka, Kazuhiro Iwai A ubiquitin ligase complex assembles linear polyubiquitin chains A ubiquitin ligase complex assembles linear polyubiquitin chains A ubiquitin ligase complex assembles linear polyubiquitin chains EMBO JOURNAL, 25, 20, 4877-4887 EMBO JOURNAL, 25, 20, 4877-4887 EMBO JOURNAL, 25, 20, 4877-4887 2006/10 Refereed English Research paper(scientific journal) Disclose to all
J Bayle, S Lopez, K Iwai, P Dubreuil, P De Sepulveda J Bayle, S Lopez, K Iwai, P Dubreuil, P De Sepulveda J Bayle, S Lopez, K Iwai, P Dubreuil, P De Sepulveda The E3 ubiquitin ligase HOIL-1 induces the polyubiquitination and degradation of SOCS6 associated proteins The E3 ubiquitin ligase HOIL-1 induces the polyubiquitination and degradation of SOCS6 associated proteins The E3 ubiquitin ligase HOIL-1 induces the polyubiquitination and degradation of SOCS6 associated proteins FEBS LETTERS, 580, 11, 2609-2614 FEBS LETTERS, 580, 11, 2609-2614 FEBS LETTERS, 580, 11, 2609-2614 2006/05 Refereed English Research paper(scientific journal) Disclose to all
K Shirakawa, A Takaori-Kondo, M Kobayashi, M Tomonaga, T Izumi, K Fukunaga, A Sasada, A Abudu, Y Miyauchi, H Akari, K Iwai, T Uchiyama K Shirakawa, A Takaori-Kondo, M Kobayashi, M Tomonaga, T Izumi, K Fukunaga, A Sasada, A Abudu, Y Miyauchi, H Akari, K Iwai, T Uchiyama K Shirakawa, A Takaori-Kondo, M Kobayashi, M Tomonaga, T Izumi, K Fukunaga, A Sasada, A Abudu, Y Miyauchi, H Akari, K Iwai, T Uchiyama Ubiquitination of APOBEC3 proteins by the Vif-Cullin5-ElonginB-ElonginC complex Ubiquitination of APOBEC3 proteins by the Vif-Cullin5-ElonginB-ElonginC complex Ubiquitination of APOBEC3 proteins by the Vif-Cullin5-ElonginB-ElonginC complex VIROLOGY, 344, 2, 263-266 VIROLOGY, 344, 2, 263-266 VIROLOGY, 344, 2, 263-266 2006/01 Refereed English Research paper(scientific journal) Disclose to all
K.L. Lorick, Y. Yang, J.P. Jensen, K. Iwai, A.M. Weissman K.L. Lorick, Y. Yang, J.P. Jensen, K. Iwai, A.M. Weissman K.L. Lorick, Y. Yang, J.P. Jensen, K. Iwai, A.M. Weissman Studies of the ubiquitin proteasome system. Studies of the ubiquitin proteasome system. Studies of the ubiquitin proteasome system. Current protocols in cell biology / editorial board, Juan S. Bonifacino ... [et al.], Chapter 15, Unit 15.9 Current protocols in cell biology / editorial board, Juan S. Bonifacino ... [et al.], Chapter 15, Unit 15.9 Current protocols in cell biology / editorial board, Juan S. Bonifacino ... [et al.], Chapter 15, Unit 15.9 2006 Refereed English Disclose to all
Iwai K, Ishikawa H Iwai K, Ishikawa H Iwai K, Ishikawa H Mechanism underlying ubiquitination of iron regulatory protein 2 (IRP2) Mechanism underlying ubiquitination of iron regulatory protein 2 (IRP2) Mechanism underlying ubiquitination of iron regulatory protein 2 (IRP2) Tanpakushitsu kakusan koso. Protein, nucleic acid, enzyme., 51, 10 Suppl, 1287-1291 Tanpakushitsu kakusan koso. Protein, nucleic acid, enzyme., 51, 10 Suppl, 1287-1291 Tanpakushitsu kakusan koso. Protein, nucleic acid, enzyme., 51, 10 Suppl, 1287-1291 2006 Refereed Disclose to all
H Ishikawa, M Kato, H Hori, K Ishimori, T Kirisako, F Tokunaga, K Iwai H Ishikawa, M Kato, H Hori, K Ishimori, T Kirisako, F Tokunaga, K Iwai H Ishikawa, M Kato, H Hori, K Ishimori, T Kirisako, F Tokunaga, K Iwai Involvement of heme regulatory motif in heme-mediated ubiquitination and degradation of IRP2 Involvement of heme regulatory motif in heme-mediated ubiquitination and degradation of IRP2 Involvement of heme regulatory motif in heme-mediated ubiquitination and degradation of IRP2 MOLECULAR CELL, 19, 2, 171-181 MOLECULAR CELL, 19, 2, 171-181 MOLECULAR CELL, 19, 2, 171-181 2005/07 Refereed English Research paper(scientific journal) Disclose to all
Y Megumi, Y Miyauchi, H Sakurai, H Nobeyama, K Lorick, E Nakamura, T Chiba, K Tanaka, AM Weissman, T Kirisako, O Ogawa, K Iwai Y Megumi, Y Miyauchi, H Sakurai, H Nobeyama, K Lorick, E Nakamura, T Chiba, K Tanaka, AM Weissman, T Kirisako, O Ogawa, K Iwai Y Megumi, Y Miyauchi, H Sakurai, H Nobeyama, K Lorick, E Nakamura, T Chiba, K Tanaka, AM Weissman, T Kirisako, O Ogawa, K Iwai Multiple roles of Rbx1 in the VBC-Cul2 ubiquitin ligase complex Multiple roles of Rbx1 in the VBC-Cul2 ubiquitin ligase complex Multiple roles of Rbx1 in the VBC-Cul2 ubiquitin ligase complex GENES TO CELLS, 10, 7, 679-691 GENES TO CELLS, 10, 7, 679-691 GENES TO CELLS, 10, 7, 679-691 2005/07 Refereed English Research paper(scientific journal) Disclose to all
M Kobayashi, A Takaori-Kondo, Y Miyauchi, K Iwai, T Uchiyama M Kobayashi, A Takaori-Kondo, Y Miyauchi, K Iwai, T Uchiyama M Kobayashi, A Takaori-Kondo, Y Miyauchi, K Iwai, T Uchiyama Ubiquitination of APOBEC3G by an HIV-1 Vif-Cullin5-Elongin B-Elongin C complex is essential for Vif function Ubiquitination of APOBEC3G by an HIV-1 Vif-Cullin5-Elongin B-Elongin C complex is essential for Vif function Ubiquitination of APOBEC3G by an HIV-1 Vif-Cullin5-Elongin B-Elongin C complex is essential for Vif function JOURNAL OF BIOLOGICAL CHEMISTRY, 280, 19, 18573-18578 JOURNAL OF BIOLOGICAL CHEMISTRY, 280, 19, 18573-18578 JOURNAL OF BIOLOGICAL CHEMISTRY, 280, 19, 18573-18578 2005/05 Refereed English Research paper(scientific journal) Disclose to all
Y Yoshida, E Adachi, K Fukiya, K Iwai, K Tanaka Y Yoshida, E Adachi, K Fukiya, K Iwai, K Tanaka Y Yoshida, E Adachi, K Fukiya, K Iwai, K Tanaka Glycoprotein-specific ubiquitin ligases recognize N-glycans in unfolded substrates Glycoprotein-specific ubiquitin ligases recognize N-glycans in unfolded substrates Glycoprotein-specific ubiquitin ligases recognize N-glycans in unfolded substrates EMBO REPORTS, 6, 3, 239-244 EMBO REPORTS, 6, 3, 239-244 EMBO REPORTS, 6, 3, 239-244 2005/03 Refereed English Research paper(scientific journal) Disclose to all
K Iwai, H Ishikawa, T Kirisako K Iwai, H Ishikawa, T Kirisako K Iwai, H Ishikawa, T Kirisako Identification, expression, and assay of an oxidation-specific ubiquitin ligase, HOIL-1 Identification, expression, and assay of an oxidation-specific ubiquitin ligase, HOIL-1 Identification, expression, and assay of an oxidation-specific ubiquitin ligase, HOIL-1 UBIQUITIN AND PROTEIN DEGRADATION, PART A, 398, 256-271 UBIQUITIN AND PROTEIN DEGRADATION, PART A, 398, 256-271 UBIQUITIN AND PROTEIN DEGRADATION, PART A, 398, 256-271 2005 Refereed English Disclose to all
T Tenno, K Fujiwara, H Tochio, K Iwai, EH Morita, H Hayashi, S Murata, H Hiroaki, M Sato, K Tanaka, M Shirakawa T Tenno, K Fujiwara, H Tochio, K Iwai, EH Morita, H Hayashi, S Murata, H Hiroaki, M Sato, K Tanaka, M Shirakawa T Tenno, K Fujiwara, H Tochio, K Iwai, EH Morita, H Hayashi, S Murata, H Hiroaki, M Sato, K Tanaka, M Shirakawa Structural basis for distinct roles of Lys63- and Lys48-linked polyubiquitin chains (vol 9, pg 865, 2004) Structural basis for distinct roles of Lys63- and Lys48-linked polyubiquitin chains (vol 9, pg 865, 2004) Structural basis for distinct roles of Lys63- and Lys48-linked polyubiquitin chains (vol 9, pg 865, 2004) GENES TO CELLS, 9, 11, 1137-1137 GENES TO CELLS, 9, 11, 1137-1137 GENES TO CELLS, 9, 11, 1137-1137 2004/11 Refereed English Disclose to all
T Tenno, K Fujiwara, H Tochio, K Iwai, EH Morita, H Hayashi, S Murata, H Hiroaki, M Sato, K Tanaka, M Shirakawa T Tenno, K Fujiwara, H Tochio, K Iwai, EH Morita, H Hayashi, S Murata, H Hiroaki, M Sato, K Tanaka, M Shirakawa T Tenno, K Fujiwara, H Tochio, K Iwai, EH Morita, H Hayashi, S Murata, H Hiroaki, M Sato, K Tanaka, M Shirakawa Structural basis for distinct roles of Lys63- and Lys48-linked polyubiquitin chains Structural basis for distinct roles of Lys63- and Lys48-linked polyubiquitin chains Structural basis for distinct roles of Lys63- and Lys48-linked polyubiquitin chains GENES TO CELLS, 9, 10, 865-875 GENES TO CELLS, 9, 10, 865-875 GENES TO CELLS, 9, 10, 865-875 2004/10 Refereed English Research paper(scientific journal) Disclose to all
H Nobeyama, T Sumi, F Misugi, E Okamoto, K Hattori, Y Matsumoto, T Yasui, K Honda, K Iwai, O Ishiko H Nobeyama, T Sumi, F Misugi, E Okamoto, K Hattori, Y Matsumoto, T Yasui, K Honda, K Iwai, O Ishiko H Nobeyama, T Sumi, F Misugi, E Okamoto, K Hattori, Y Matsumoto, T Yasui, K Honda, K Iwai, O Ishiko Association of HPV infection with prognosis after neoadjuvant chemotherapy in advanced uterine cervical cancer Association of HPV infection with prognosis after neoadjuvant chemotherapy in advanced uterine cervical cancer Association of HPV infection with prognosis after neoadjuvant chemotherapy in advanced uterine cervical cancer INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE, 14, 1, 101-105 INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE, 14, 1, 101-105 INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE, 14, 1, 101-105 2004/07 Refereed English Research paper(scientific journal) Disclose to all
A Ciechanover, K Iwai A Ciechanover, K Iwai A Ciechanover, K Iwai The ubiquitin system: From basic mechanisms to the patient bed The ubiquitin system: From basic mechanisms to the patient bed The ubiquitin system: From basic mechanisms to the patient bed IUBMB LIFE, 56, 4, 193-201 IUBMB LIFE, 56, 4, 193-201 IUBMB LIFE, 56, 4, 193-201 2004/04 Refereed English Disclose to all
T Mizushima, T Hirao, Y Yoshida, SJ Lee, T Chiba, K Iwai, Y Yamaguchi, K Kato, T Tsukihara, K Tanaka T Mizushima, T Hirao, Y Yoshida, SJ Lee, T Chiba, K Iwai, Y Yamaguchi, K Kato, T Tsukihara, K Tanaka T Mizushima, T Hirao, Y Yoshida, SJ Lee, T Chiba, K Iwai, Y Yamaguchi, K Kato, T Tsukihara, K Tanaka Structural basis of sugar-recognizing ubiquitin ligase Structural basis of sugar-recognizing ubiquitin ligase Structural basis of sugar-recognizing ubiquitin ligase NATURE STRUCTURAL & MOLECULAR BIOLOGY, 11, 4, 365-370 NATURE STRUCTURAL & MOLECULAR BIOLOGY, 11, 4, 365-370 NATURE STRUCTURAL & MOLECULAR BIOLOGY, 11, 4, 365-370 2004/04 Refereed English Research paper(scientific journal) Disclose to all
EG Meyron-Holtz, MC Ghosh, K Iwai, T LaVaute, Brazzolotto, X, UV Berger, W Land, H Ollivierre-Wilson, A Grinberg, P Love, TA Rouault EG Meyron-Holtz, MC Ghosh, K Iwai, T LaVaute, Brazzolotto, X, UV Berger, W Land, H Ollivierre-Wilson, A Grinberg, P Love, TA Rouault EG Meyron-Holtz, MC Ghosh, K Iwai, T LaVaute, Brazzolotto, X, UV Berger, W Land, H Ollivierre-Wilson, A Grinberg, P Love, TA Rouault Genetic ablations of iron regulatory proteins 1 and 2 reveal why iron regulatory protein 2 dominates iron homeostasis Genetic ablations of iron regulatory proteins 1 and 2 reveal why iron regulatory protein 2 dominates iron homeostasis Genetic ablations of iron regulatory proteins 1 and 2 reveal why iron regulatory protein 2 dominates iron homeostasis EMBO JOURNAL, 23, 2, 386-395 EMBO JOURNAL, 23, 2, 386-395 EMBO JOURNAL, 23, 2, 386-395 2004/01 Refereed English Research paper(scientific journal) Disclose to all
Y Yoshida, F Tokunaga, T Chiba, K Iwai, K Tanaka, T Tai Y Yoshida, F Tokunaga, T Chiba, K Iwai, K Tanaka, T Tai Y Yoshida, F Tokunaga, T Chiba, K Iwai, K Tanaka, T Tai Fbs2 is a new member of the E3 ubiquitin ligase family that recognizes sugar chains Fbs2 is a new member of the E3 ubiquitin ligase family that recognizes sugar chains Fbs2 is a new member of the E3 ubiquitin ligase family that recognizes sugar chains JOURNAL OF BIOLOGICAL CHEMISTRY, 278, 44, 43877-43884 JOURNAL OF BIOLOGICAL CHEMISTRY, 278, 44, 43877-43884 JOURNAL OF BIOLOGICAL CHEMISTRY, 278, 44, 43877-43884 2003/10 Refereed English Research paper(scientific journal) Disclose to all
K Iwai K Iwai K Iwai An ubiquitin ligase recognizing a protein oxidized by iron: Implications for the turnover of oxidatively damaged proteins An ubiquitin ligase recognizing a protein oxidized by iron: Implications for the turnover of oxidatively damaged proteins An ubiquitin ligase recognizing a protein oxidized by iron: Implications for the turnover of oxidatively damaged proteins JOURNAL OF BIOCHEMISTRY, 134, 2, 175-182 JOURNAL OF BIOCHEMISTRY, 134, 2, 175-182 JOURNAL OF BIOCHEMISTRY, 134, 2, 175-182 2003/08 Refereed English Disclose to all
D Ishida, K Kometani, HL Yang, K Kakugawa, K Masuda, K Iwai, M Suzuki, S Itohara, T Nakahata, H Hiai, H Kawamoto, M Hattori, N Minato D Ishida, K Kometani, HL Yang, K Kakugawa, K Masuda, K Iwai, M Suzuki, S Itohara, T Nakahata, H Hiai, H Kawamoto, M Hattori, N Minato D Ishida, K Kometani, HL Yang, K Kakugawa, K Masuda, K Iwai, M Suzuki, S Itohara, T Nakahata, H Hiai, H Kawamoto, M Hattori, N Minato Myeloproliferative stem cell disorders by deregulated Rap1 activation in SPA-1-deficient mice Myeloproliferative stem cell disorders by deregulated Rap1 activation in SPA-1-deficient mice Myeloproliferative stem cell disorders by deregulated Rap1 activation in SPA-1-deficient mice CANCER CELL, 4, 1, 55-65 CANCER CELL, 4, 1, 55-65 CANCER CELL, 4, 1, 55-65 2003/07 Refereed English Research paper(scientific journal) Disclose to all
K Yamanaka, H Ishikawa, Y Megumi, F Tokunaga, M Kanie, TA Rouault, Morishima, I, N Minato, K Ishimori, K Iwai K Yamanaka, H Ishikawa, Y Megumi, F Tokunaga, M Kanie, TA Rouault, Morishima, I, N Minato, K Ishimori, K Iwai K Yamanaka, H Ishikawa, Y Megumi, F Tokunaga, M Kanie, TA Rouault, Morishima, I, N Minato, K Ishimori, K Iwai Identification of the ubiquitin-protein ligase that recognizes oxidized IRP2 Identification of the ubiquitin-protein ligase that recognizes oxidized IRP2 Identification of the ubiquitin-protein ligase that recognizes oxidized IRP2 NATURE CELL BIOLOGY, 5, 4, 336-340 NATURE CELL BIOLOGY, 5, 4, 336-340 NATURE CELL BIOLOGY, 5, 4, 336-340 2003/04 Refereed English Research paper(scientific journal) Disclose to all
M Ashizuka, T Fukuda, T Nakamura, K Shirasuna, K Iwai, H Izumi, K Kohno, M Kuwano, T Uchiumi M Ashizuka, T Fukuda, T Nakamura, K Shirasuna, K Iwai, H Izumi, K Kohno, M Kuwano, T Uchiumi M Ashizuka, T Fukuda, T Nakamura, K Shirasuna, K Iwai, H Izumi, K Kohno, M Kuwano, T Uchiumi Novel translational control through an iron-responsive element by interaction of multifunctional protein YB-1 and IRP2 Novel translational control through an iron-responsive element by interaction of multifunctional protein YB-1 and IRP2 Novel translational control through an iron-responsive element by interaction of multifunctional protein YB-1 and IRP2 MOLECULAR AND CELLULAR BIOLOGY, 22, 18, 6375-6383 MOLECULAR AND CELLULAR BIOLOGY, 22, 18, 6375-6383 MOLECULAR AND CELLULAR BIOLOGY, 22, 18, 6375-6383 2002/09 Refereed English Research paper(scientific journal) Disclose to all
Yoshida, Y, Chiba, T, Tokunaga, F, Kawasaki, H, Iwai, K, Suzuki, T, Ito, Y, Matsuoka, K, Yoshida, M, Tanaka, K, Tai, T Yoshida, Y, Chiba, T, Tokunaga, F, Kawasaki, H, Iwai, K, Suzuki, T, Ito, Y, Matsuoka, K, Yoshida, M, Tanaka, K, Tai, T Yoshida, Y, Chiba, T, Tokunaga, F, Kawasaki, H, Iwai, K, Suzuki, T, Ito, Y, Matsuoka, K, Yoshida, M, Tanaka, K, Tai, T E3 ubigutin ligase that recognizes sugar chains E3 ubigutin ligase that recognizes sugar chains E3 ubigutin ligase that recognizes sugar chains Nature, 418, 6896, 438-442 Nature, 418, 6896, 438-442 Nature, 418, 6896, 438-442 2002/07 Refereed English Research paper(scientific journal) Disclose to all
RE Amir, K Iwai, A Ciechanover RE Amir, K Iwai, A Ciechanover RE Amir, K Iwai, A Ciechanover The NEDD8 pathway is essential for SCF beta-TrCp-mediated ubiquitination and processing of the NF-kappa B precursor p105 The NEDD8 pathway is essential for SCF beta-TrCp-mediated ubiquitination and processing of the NF-kappa B precursor p105 The NEDD8 pathway is essential for SCF beta-TrCp-mediated ubiquitination and processing of the NF-kappa B precursor p105 JOURNAL OF BIOLOGICAL CHEMISTRY, 277, 26, 23253-23259 JOURNAL OF BIOLOGICAL CHEMISTRY, 277, 26, 23253-23259 JOURNAL OF BIOLOGICAL CHEMISTRY, 277, 26, 23253-23259 2002/06 Refereed English Research paper(scientific journal) Disclose to all
A Sasaki, Y Masuda, K Iwai, K Ikeda, K Watanabe A Sasaki, Y Masuda, K Iwai, K Ikeda, K Watanabe A Sasaki, Y Masuda, K Iwai, K Ikeda, K Watanabe A RING finger protein praja1 regulates Dlx5-dependent transcription through its ubiquitin ligase activity for the Dlx/Msx-interacting MAGE/Needin family protein, Dlxin-1 A RING finger protein praja1 regulates Dlx5-dependent transcription through its ubiquitin ligase activity for the Dlx/Msx-interacting MAGE/Needin family protein, Dlxin-1 A RING finger protein praja1 regulates Dlx5-dependent transcription through its ubiquitin ligase activity for the Dlx/Msx-interacting MAGE/Needin family protein, Dlxin-1 JOURNAL OF BIOLOGICAL CHEMISTRY, 277, 25, 22541-22546 JOURNAL OF BIOLOGICAL CHEMISTRY, 277, 25, 22541-22546 JOURNAL OF BIOLOGICAL CHEMISTRY, 277, 25, 22541-22546 2002/06 Refereed English Research paper(scientific journal) Disclose to all
H Okuda, K Saitoh, S Hirai, K Iwai, Y Takaki, M Baba, N Minato, S Ohno, T Shuin H Okuda, K Saitoh, S Hirai, K Iwai, Y Takaki, M Baba, N Minato, S Ohno, T Shuin H Okuda, K Saitoh, S Hirai, K Iwai, Y Takaki, M Baba, N Minato, S Ohno, T Shuin The von Hippel-Lindau tumor suppressor protein mediates ubiquitination of activated atypical protein kinase C The von Hippel-Lindau tumor suppressor protein mediates ubiquitination of activated atypical protein kinase C The von Hippel-Lindau tumor suppressor protein mediates ubiquitination of activated atypical protein kinase C JOURNAL OF BIOLOGICAL CHEMISTRY, 276, 47, 43611-43617 JOURNAL OF BIOLOGICAL CHEMISTRY, 276, 47, 43611-43617 JOURNAL OF BIOLOGICAL CHEMISTRY, 276, 47, 43611-43617 2001/11 Refereed English Research paper(scientific journal) Disclose to all
T Kawakami, T Chiba, T Suzuki, K Iwai, K Yamanaka, N Minato, H Suzuki, N Shimbara, Y Hidaka, F Osaka, M Omata, K Tanaka T Kawakami, T Chiba, T Suzuki, K Iwai, K Yamanaka, N Minato, H Suzuki, N Shimbara, Y Hidaka, F Osaka, M Omata, K Tanaka T Kawakami, T Chiba, T Suzuki, K Iwai, K Yamanaka, N Minato, H Suzuki, N Shimbara, Y Hidaka, F Osaka, M Omata, K Tanaka NEDD8 recruits E2-ubiquitin to SCF E3 ligase NEDD8 recruits E2-ubiquitin to SCF E3 ligase NEDD8 recruits E2-ubiquitin to SCF E3 ligase EMBO JOURNAL, 20, 15, 4003-4012 EMBO JOURNAL, 20, 15, 4003-4012 EMBO JOURNAL, 20, 15, 4003-4012 2001/08 Refereed English Research paper(scientific journal) Disclose to all
A Ciechanover, H Gonen, B Bercovich, S Cohen, Fajerman, I, A Israel, F Mercurio, C Kahana, AL Schwartz, K Iwai, A Orian A Ciechanover, H Gonen, B Bercovich, S Cohen, Fajerman, I, A Israel, F Mercurio, C Kahana, AL Schwartz, K Iwai, A Orian A Ciechanover, H Gonen, B Bercovich, S Cohen, Fajerman, I, A Israel, F Mercurio, C Kahana, AL Schwartz, K Iwai, A Orian Mechanisms of ubiquitin-mediated, limited processing of the NF-kappa B1 precursor protein p105 Mechanisms of ubiquitin-mediated, limited processing of the NF-kappa B1 precursor protein p105 Mechanisms of ubiquitin-mediated, limited processing of the NF-kappa B1 precursor protein p105 BIOCHIMIE, 83, 3-4, 341-349 BIOCHIMIE, 83, 3-4, 341-349 BIOCHIMIE, 83, 3-4, 341-349 2001/03 Refereed English Research paper(scientific journal) Disclose to all
T LaVaute, S Smith, S Cooperman, K Iwai, W Land, E Meyron-Holtz, SK Drake, G Miller, M Abu-Asab, M Tsokos, R Switzer, A Grinberg, P Love, N Tresser, TA Rouault T LaVaute, S Smith, S Cooperman, K Iwai, W Land, E Meyron-Holtz, SK Drake, G Miller, M Abu-Asab, M Tsokos, R Switzer, A Grinberg, P Love, N Tresser, TA Rouault T LaVaute, S Smith, S Cooperman, K Iwai, W Land, E Meyron-Holtz, SK Drake, G Miller, M Abu-Asab, M Tsokos, R Switzer, A Grinberg, P Love, N Tresser, TA Rouault Targeted deletion of the gene encoding iron regulatory protein-2 causes misregulation of iron metabolism and neurodegenerative disease in mice Targeted deletion of the gene encoding iron regulatory protein-2 causes misregulation of iron metabolism and neurodegenerative disease in mice Targeted deletion of the gene encoding iron regulatory protein-2 causes misregulation of iron metabolism and neurodegenerative disease in mice NATURE GENETICS, 27, 2, 209-214 NATURE GENETICS, 27, 2, 209-214 NATURE GENETICS, 27, 2, 209-214 2001/02 Refereed English Research paper(scientific journal) Disclose to all
H Shimura, N Hattori, S Kubo, Y Mizuno, S Asakawa, S Minoshima, N Shimizu, K Iwai, T Chiba, K Tanaka, T Suzuki H Shimura, N Hattori, S Kubo, Y Mizuno, S Asakawa, S Minoshima, N Shimizu, K Iwai, T Chiba, K Tanaka, T Suzuki H Shimura, N Hattori, S Kubo, Y Mizuno, S Asakawa, S Minoshima, N Shimizu, K Iwai, T Chiba, K Tanaka, T Suzuki Familial Parkinson disease gene product, parkin, is a ubiquitin-protein ligase Familial Parkinson disease gene product, parkin, is a ubiquitin-protein ligase Familial Parkinson disease gene product, parkin, is a ubiquitin-protein ligase NATURE GENETICS, 25, 3, 302-305 NATURE GENETICS, 25, 3, 302-305 NATURE GENETICS, 25, 3, 302-305 2000/07 Refereed English Research paper(scientific journal) Disclose to all
A Orian, H Gonen, B Bercovich, Fajerman, I, E Eytan, A Israel, F Mercurio, K Iwai, AL Schwartz, A Ciechanover A Orian, H Gonen, B Bercovich, Fajerman, I, E Eytan, A Israel, F Mercurio, K Iwai, AL Schwartz, A Ciechanover A Orian, H Gonen, B Bercovich, Fajerman, I, E Eytan, A Israel, F Mercurio, K Iwai, AL Schwartz, A Ciechanover SCF beta-TrcP ubiquitin ligase-mediated processing of NF-kappa B p105 requires phosphorylation of its C-terminus by I kappa B kinase SCF beta-TrcP ubiquitin ligase-mediated processing of NF-kappa B p105 requires phosphorylation of its C-terminus by I kappa B kinase SCF beta-TrcP ubiquitin ligase-mediated processing of NF-kappa B p105 requires phosphorylation of its C-terminus by I kappa B kinase EMBO JOURNAL, 19, 11, 2580-2591 EMBO JOURNAL, 19, 11, 2580-2591 EMBO JOURNAL, 19, 11, 2580-2591 2000/06 Refereed English Research paper(scientific journal) Disclose to all
E Sadot, Simcha, I, K Iwai, A Ciechanover, B Geiger, A Ben-Ze'ev E Sadot, Simcha, I, K Iwai, A Ciechanover, B Geiger, A Ben-Ze'ev E Sadot, Simcha, I, K Iwai, A Ciechanover, B Geiger, A Ben-Ze'ev Differential interaction of plakoglobin and beta-catenin with the ubiquitin-proteasome system Differential interaction of plakoglobin and beta-catenin with the ubiquitin-proteasome system Differential interaction of plakoglobin and beta-catenin with the ubiquitin-proteasome system ONCOGENE, 19, 16, 1992-2001 ONCOGENE, 19, 16, 1992-2001 ONCOGENE, 19, 16, 1992-2001 2000/04 Refereed English Research paper(scientific journal) Disclose to all
G Levkowitz, H Waterman, SA Ettenberg, M Katz, AY Tsygankov, Alroy, I, S Lavi, K Iwai, Y Reiss, A Ciechanover, S Lipkowitz, Y Yarden G Levkowitz, H Waterman, SA Ettenberg, M Katz, AY Tsygankov, Alroy, I, S Lavi, K Iwai, Y Reiss, A Ciechanover, S Lipkowitz, Y Yarden G Levkowitz, H Waterman, SA Ettenberg, M Katz, AY Tsygankov, Alroy, I, S Lavi, K Iwai, Y Reiss, A Ciechanover, S Lipkowitz, Y Yarden Ubiquitin ligase activity and tyrosine phosphorylation underlie suppression of growth factor signaling by c-Cbl/Sli-1 Ubiquitin ligase activity and tyrosine phosphorylation underlie suppression of growth factor signaling by c-Cbl/Sli-1 Ubiquitin ligase activity and tyrosine phosphorylation underlie suppression of growth factor signaling by c-Cbl/Sli-1 MOLECULAR CELL, 4, 6, 1029-1040 MOLECULAR CELL, 4, 6, 1029-1040 MOLECULAR CELL, 4, 6, 1029-1040 1999/12 Refereed English Research paper(scientific journal) Disclose to all
H Gonen, B Bercovich, A Orian, A Carrano, C Takizawa, K Yamanaka, M Pagano, K Iwai, A Ciechanover H Gonen, B Bercovich, A Orian, A Carrano, C Takizawa, K Yamanaka, M Pagano, K Iwai, A Ciechanover H Gonen, B Bercovich, A Orian, A Carrano, C Takizawa, K Yamanaka, M Pagano, K Iwai, A Ciechanover Identification of the ubiquitin carrier proteins, E2s, involved in signal-induced conjugation and subsequent degradation of I kappa B alpha Identification of the ubiquitin carrier proteins, E2s, involved in signal-induced conjugation and subsequent degradation of I kappa B alpha Identification of the ubiquitin carrier proteins, E2s, involved in signal-induced conjugation and subsequent degradation of I kappa B alpha JOURNAL OF BIOLOGICAL CHEMISTRY, 274, 21, 14823-14830 JOURNAL OF BIOLOGICAL CHEMISTRY, 274, 21, 14823-14830 JOURNAL OF BIOLOGICAL CHEMISTRY, 274, 21, 14823-14830 1999/05 Refereed English Research paper(scientific journal) Disclose to all
E Nakamura, M Sato, HL Yang, F Miyagawa, M Harasaki, K Tomita, S Matsuoka, A Noma, K Iwai, N Minato E Nakamura, M Sato, HL Yang, F Miyagawa, M Harasaki, K Tomita, S Matsuoka, A Noma, K Iwai, N Minato E Nakamura, M Sato, HL Yang, F Miyagawa, M Harasaki, K Tomita, S Matsuoka, A Noma, K Iwai, N Minato 4F2 (CD98) heavy chain is associated covalently with an amino acid transporter and controls intracellular trafficking and membrane topology of 4F2 heterodimer 4F2 (CD98) heavy chain is associated covalently with an amino acid transporter and controls intracellular trafficking and membrane topology of 4F2 heterodimer 4F2 (CD98) heavy chain is associated covalently with an amino acid transporter and controls intracellular trafficking and membrane topology of 4F2 heterodimer JOURNAL OF BIOLOGICAL CHEMISTRY, 274, 5, 3009-3016 JOURNAL OF BIOLOGICAL CHEMISTRY, 274, 5, 3009-3016 JOURNAL OF BIOLOGICAL CHEMISTRY, 274, 5, 3009-3016 1999/01 Refereed English Research paper(scientific journal) Disclose to all
K. Yamanaka, N. Minato, K. Iwai K. Yamanaka, N. Minato, K. Iwai K. Yamanaka, N. Minato, K. Iwai Stabilization of iron regulatory protein 2, IRP2, by aluminum Stabilization of iron regulatory protein 2, IRP2, by aluminum Stabilization of iron regulatory protein 2, IRP2, by aluminum FEBS Letters, 462, 1-2, 216-220 FEBS Letters, 462, 1-2, 216-220 FEBS Letters, 462, 1-2, 216-220 1999 Refereed English Disclose to all
H Kurachi, Y Wada, N Tsukamoto, M Maeda, H Kubota, M Hattori, K Iwai, N Minato H Kurachi, Y Wada, N Tsukamoto, M Maeda, H Kubota, M Hattori, K Iwai, N Minato H Kurachi, Y Wada, N Tsukamoto, M Maeda, H Kubota, M Hattori, K Iwai, N Minato Human SPA-1 gene product selectively expressed in lymphoid tissues is a specific GTPase-activating protein for Rap1 and Rap2 - Segregate expression profiles from a rap1GAP gene product Human SPA-1 gene product selectively expressed in lymphoid tissues is a specific GTPase-activating protein for Rap1 and Rap2 - Segregate expression profiles from a rap1GAP gene product Human SPA-1 gene product selectively expressed in lymphoid tissues is a specific GTPase-activating protein for Rap1 and Rap2 - Segregate expression profiles from a rap1GAP gene product JOURNAL OF BIOLOGICAL CHEMISTRY, 272, 44, 28081-28088 JOURNAL OF BIOLOGICAL CHEMISTRY, 272, 44, 28081-28088 JOURNAL OF BIOLOGICAL CHEMISTRY, 272, 44, 28081-28088 1997/10 Refereed English Research paper(scientific journal) Disclose to all
Y Wada, H Kubota, M Maeda, M Taniwaki, M Hattori, S Imamura, K Iwai, N Minato Y Wada, H Kubota, M Maeda, M Taniwaki, M Hattori, S Imamura, K Iwai, N Minato Y Wada, H Kubota, M Maeda, M Taniwaki, M Hattori, S Imamura, K Iwai, N Minato Mitogen-inducible SIPA1 is mapped to the conserved syntenic groups of chromosome 19 in mouse and chromosome 11q13.3 centromeric to BCL1 in human Mitogen-inducible SIPA1 is mapped to the conserved syntenic groups of chromosome 19 in mouse and chromosome 11q13.3 centromeric to BCL1 in human Mitogen-inducible SIPA1 is mapped to the conserved syntenic groups of chromosome 19 in mouse and chromosome 11q13.3 centromeric to BCL1 in human GENOMICS, 39, 1, 66-73 GENOMICS, 39, 1, 66-73 GENOMICS, 39, 1, 66-73 1997/01 Refereed English Research paper(scientific journal) Disclose to all
HY Kim, T LaVaute, K Iwai, RD Klausner, TA Rouault HY Kim, T LaVaute, K Iwai, RD Klausner, TA Rouault HY Kim, T LaVaute, K Iwai, RD Klausner, TA Rouault Identification of a conserved and functional iron-responsive element in the 5'-untranslated region of mammalian mitochondrial aconitase Identification of a conserved and functional iron-responsive element in the 5'-untranslated region of mammalian mitochondrial aconitase Identification of a conserved and functional iron-responsive element in the 5'-untranslated region of mammalian mitochondrial aconitase JOURNAL OF BIOLOGICAL CHEMISTRY, 271, 39, 24226-24230 JOURNAL OF BIOLOGICAL CHEMISTRY, 271, 39, 24226-24230 JOURNAL OF BIOLOGICAL CHEMISTRY, 271, 39, 24226-24230 1996/09 Refereed English Research paper(scientific journal) Disclose to all
K IWAI, RD KLAUSNER, TA ROUAULT K IWAI, RD KLAUSNER, TA ROUAULT K IWAI, RD KLAUSNER, TA ROUAULT REQUIREMENTS FOR IRON-REGULATED DEGRADATION OF THE RNA-BINDING PROTEIN, IRON REGULATORY PROTEIN-2 REQUIREMENTS FOR IRON-REGULATED DEGRADATION OF THE RNA-BINDING PROTEIN, IRON REGULATORY PROTEIN-2 REQUIREMENTS FOR IRON-REGULATED DEGRADATION OF THE RNA-BINDING PROTEIN, IRON REGULATORY PROTEIN-2 EMBO JOURNAL, 14, 21, 5350-5357 EMBO JOURNAL, 14, 21, 5350-5357 EMBO JOURNAL, 14, 21, 5350-5357 1995/11 Refereed English Research paper(scientific journal) Disclose to all
PA DERUSSO, CC PHILPOTT, K IWAI, HS MOSTOWSKI, RD KLAUSNER, TA ROUAULT PA DERUSSO, CC PHILPOTT, K IWAI, HS MOSTOWSKI, RD KLAUSNER, TA ROUAULT PA DERUSSO, CC PHILPOTT, K IWAI, HS MOSTOWSKI, RD KLAUSNER, TA ROUAULT EXPRESSION OF A CONSTITUTIVE MUTANT OF IRON REGULATORY PROTEIN-1 ABOLISHES IRON HOMEOSTASIS IN MAMMALIAN-CELLS EXPRESSION OF A CONSTITUTIVE MUTANT OF IRON REGULATORY PROTEIN-1 ABOLISHES IRON HOMEOSTASIS IN MAMMALIAN-CELLS EXPRESSION OF A CONSTITUTIVE MUTANT OF IRON REGULATORY PROTEIN-1 ABOLISHES IRON HOMEOSTASIS IN MAMMALIAN-CELLS JOURNAL OF BIOLOGICAL CHEMISTRY, 270, 26, 15451-15454 JOURNAL OF BIOLOGICAL CHEMISTRY, 270, 26, 15451-15454 JOURNAL OF BIOLOGICAL CHEMISTRY, 270, 26, 15451-15454 1995/06 Refereed English Disclose to all
M HATTORI, N TSUKAMOTO, MSA NUREKAMAL, B RUBINFELD, K IWAI, H KUBOTA, H MARUTA, N MINATO M HATTORI, N TSUKAMOTO, MSA NUREKAMAL, B RUBINFELD, K IWAI, H KUBOTA, H MARUTA, N MINATO M HATTORI, N TSUKAMOTO, MSA NUREKAMAL, B RUBINFELD, K IWAI, H KUBOTA, H MARUTA, N MINATO MOLECULAR-CLONING OF A NOVEL MITOGEN-INDUCIBLE NUCLEAR-PROTEIN WITH A RAN GTPASE-ACTIVATING DOMAIN THAT AFFECTS CELL-CYCLE PROGRESSION MOLECULAR-CLONING OF A NOVEL MITOGEN-INDUCIBLE NUCLEAR-PROTEIN WITH A RAN GTPASE-ACTIVATING DOMAIN THAT AFFECTS CELL-CYCLE PROGRESSION MOLECULAR-CLONING OF A NOVEL MITOGEN-INDUCIBLE NUCLEAR-PROTEIN WITH A RAN GTPASE-ACTIVATING DOMAIN THAT AFFECTS CELL-CYCLE PROGRESSION MOLECULAR AND CELLULAR BIOLOGY, 15, 1, 552-560 MOLECULAR AND CELLULAR BIOLOGY, 15, 1, 552-560 MOLECULAR AND CELLULAR BIOLOGY, 15, 1, 552-560 1995/01 Refereed English Research paper(scientific journal) Disclose to all
F SAMANIEGO, J CHIN, K IWAI, TA ROUAULT, RD KLAUSNER F SAMANIEGO, J CHIN, K IWAI, TA ROUAULT, RD KLAUSNER F SAMANIEGO, J CHIN, K IWAI, TA ROUAULT, RD KLAUSNER MOLECULAR CHARACTERIZATION OF A 2ND IRON-RESPONSIVE ELEMENT-BINDING PROTEIN, IRON REGULATORY PROTEIN-2 - STRUCTURE, FUNCTION, AND POSTTRANSLATIONAL REGULATION MOLECULAR CHARACTERIZATION OF A 2ND IRON-RESPONSIVE ELEMENT-BINDING PROTEIN, IRON REGULATORY PROTEIN-2 - STRUCTURE, FUNCTION, AND POSTTRANSLATIONAL REGULATION MOLECULAR CHARACTERIZATION OF A 2ND IRON-RESPONSIVE ELEMENT-BINDING PROTEIN, IRON REGULATORY PROTEIN-2 - STRUCTURE, FUNCTION, AND POSTTRANSLATIONAL REGULATION JOURNAL OF BIOLOGICAL CHEMISTRY, 269, 49, 30904-30910 JOURNAL OF BIOLOGICAL CHEMISTRY, 269, 49, 30904-30910 JOURNAL OF BIOLOGICAL CHEMISTRY, 269, 49, 30904-30910 1994/12 Refereed English Research paper(scientific journal) Disclose to all
H KUBOTA, M SATO, Y OGAWA, K IWAI, M HATTORI, T YOSHIDA, N MINATO H KUBOTA, M SATO, Y OGAWA, K IWAI, M HATTORI, T YOSHIDA, N MINATO H KUBOTA, M SATO, Y OGAWA, K IWAI, M HATTORI, T YOSHIDA, N MINATO INVOLVEMENT OF 4F2 ANTIGEN EXPRESSED ON THE MHC-NEGATIVE TARGET-CELLS IN THE RECOGNITION OF MURINE CD3+CD4-CD8- ALPHA-BETA (V(ALPHA)4/V(BETA)2) T-CELLS INVOLVEMENT OF 4F2 ANTIGEN EXPRESSED ON THE MHC-NEGATIVE TARGET-CELLS IN THE RECOGNITION OF MURINE CD3+CD4-CD8- ALPHA-BETA (V(ALPHA)4/V(BETA)2) T-CELLS INVOLVEMENT OF 4F2 ANTIGEN EXPRESSED ON THE MHC-NEGATIVE TARGET-CELLS IN THE RECOGNITION OF MURINE CD3+CD4-CD8- ALPHA-BETA (V(ALPHA)4/V(BETA)2) T-CELLS INTERNATIONAL IMMUNOLOGY, 6, 9, 1323-1331 INTERNATIONAL IMMUNOLOGY, 6, 9, 1323-1331 INTERNATIONAL IMMUNOLOGY, 6, 9, 1323-1331 1994/09 Refereed English Research paper(scientific journal) Disclose to all
M. Tomana, S. Ideyama, K. Iwai, J.-I. Gyotoku, W.T.V. Germeraad, S. Muramatsu, Y. Katsura M. Tomana, S. Ideyama, K. Iwai, J.-I. Gyotoku, W.T.V. Germeraad, S. Muramatsu, Y. Katsura M. Tomana, S. Ideyama, K. Iwai, J.-I. Gyotoku, W.T.V. Germeraad, S. Muramatsu, Y. Katsura Involvement of IL-7 in the development of γδ T cells in the thymus Involvement of IL-7 in the development of γδ T cells in the thymus Involvement of IL-7 in the development of γδ T cells in the thymus Thymus, 21, 3, 141-157 Thymus, 21, 3, 141-157 Thymus, 21, 3, 141-157 1993 Refereed English Disclose to all
M MURAKAMI, S KUMAGAI, M SUGITA, K IWAI, H IMURA M MURAKAMI, S KUMAGAI, M SUGITA, K IWAI, H IMURA M MURAKAMI, S KUMAGAI, M SUGITA, K IWAI, H IMURA INVITRO INDUCTION OF IGG ANTI-DNA ANTIBODY FROM HIGH-DENSITY B-CELLS OF SYSTEMIC LUPUS-ERYTHEMATOSUS PATIENTS BY AN HLA DR-RESTRICTED T-CELL CLONE INVITRO INDUCTION OF IGG ANTI-DNA ANTIBODY FROM HIGH-DENSITY B-CELLS OF SYSTEMIC LUPUS-ERYTHEMATOSUS PATIENTS BY AN HLA DR-RESTRICTED T-CELL CLONE INVITRO INDUCTION OF IGG ANTI-DNA ANTIBODY FROM HIGH-DENSITY B-CELLS OF SYSTEMIC LUPUS-ERYTHEMATOSUS PATIENTS BY AN HLA DR-RESTRICTED T-CELL CLONE CLINICAL AND EXPERIMENTAL IMMUNOLOGY, 90, 2, 245-250 CLINICAL AND EXPERIMENTAL IMMUNOLOGY, 90, 2, 245-250 CLINICAL AND EXPERIMENTAL IMMUNOLOGY, 90, 2, 245-250 1992/11 Refereed English Research paper(scientific journal) Disclose to all
Y WATANABE, O MAZDA, Y AIBA, K IWAI, J GYOTOKU, S IDEYAMA, J MIYAZAKI, Y KATSURA Y WATANABE, O MAZDA, Y AIBA, K IWAI, J GYOTOKU, S IDEYAMA, J MIYAZAKI, Y KATSURA Y WATANABE, O MAZDA, Y AIBA, K IWAI, J GYOTOKU, S IDEYAMA, J MIYAZAKI, Y KATSURA A MURINE THYMIC STROMAL CELL-LINE WHICH MAY SUPPORT THE DIFFERENTIATION OF CD4-8- THYMOCYTES INTO CD4+8- ALPHA-BETA-T-CELL RECEPTOR POSITIVE T-CELLS A MURINE THYMIC STROMAL CELL-LINE WHICH MAY SUPPORT THE DIFFERENTIATION OF CD4-8- THYMOCYTES INTO CD4+8- ALPHA-BETA-T-CELL RECEPTOR POSITIVE T-CELLS A MURINE THYMIC STROMAL CELL-LINE WHICH MAY SUPPORT THE DIFFERENTIATION OF CD4-8- THYMOCYTES INTO CD4+8- ALPHA-BETA-T-CELL RECEPTOR POSITIVE T-CELLS CELLULAR IMMUNOLOGY, 142, 2, 385-397 CELLULAR IMMUNOLOGY, 142, 2, 385-397 CELLULAR IMMUNOLOGY, 142, 2, 385-397 1992/07 Refereed English Research paper(scientific journal) Disclose to all
K IWAI, T TSUBATA, Y KATSURA, S KUMAGAI, H IMURA K IWAI, T TSUBATA, Y KATSURA, S KUMAGAI, H IMURA K IWAI, T TSUBATA, Y KATSURA, S KUMAGAI, H IMURA QUALITATIVE DIFFERENCE OF ANTI-DNA ANTIBODY-PRODUCING CELL PRECURSORS IN THE PREIMMUNE B-CELL REPERTOIRE BETWEEN NORMAL AND LUPUS-PRONE MICE QUALITATIVE DIFFERENCE OF ANTI-DNA ANTIBODY-PRODUCING CELL PRECURSORS IN THE PREIMMUNE B-CELL REPERTOIRE BETWEEN NORMAL AND LUPUS-PRONE MICE QUALITATIVE DIFFERENCE OF ANTI-DNA ANTIBODY-PRODUCING CELL PRECURSORS IN THE PREIMMUNE B-CELL REPERTOIRE BETWEEN NORMAL AND LUPUS-PRONE MICE CLINICAL AND EXPERIMENTAL IMMUNOLOGY, 86, 1, 106-111 CLINICAL AND EXPERIMENTAL IMMUNOLOGY, 86, 1, 106-111 CLINICAL AND EXPERIMENTAL IMMUNOLOGY, 86, 1, 106-111 1991/10 Refereed English Research paper(scientific journal) Disclose to all
M SUGITA, S KUMAGAI, H UMEHARA, K IWAI, K SORACHI, H IMURA M SUGITA, S KUMAGAI, H UMEHARA, K IWAI, K SORACHI, H IMURA M SUGITA, S KUMAGAI, H UMEHARA, K IWAI, K SORACHI, H IMURA HLA-DQ-SPECIFIC AUTOREACTIVE T-CELL CLONE WITH HELPER AND CYTOTOXIC FUNCTIONS HLA-DQ-SPECIFIC AUTOREACTIVE T-CELL CLONE WITH HELPER AND CYTOTOXIC FUNCTIONS HLA-DQ-SPECIFIC AUTOREACTIVE T-CELL CLONE WITH HELPER AND CYTOTOXIC FUNCTIONS IMMUNOLOGY LETTERS, 26, 3, 265-270 IMMUNOLOGY LETTERS, 26, 3, 265-270 IMMUNOLOGY LETTERS, 26, 3, 265-270 1990/12 Refereed English Research paper(scientific journal) Disclose to all

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Title language:
Misc
Author Author(Japanese) Author(English) Title Title(Japanese) Title(English) Bibliography Bibliography(Japanese) Bibliography(English) Publication date Refereed paper Language Publishing type Disclose
Donna Alexandra MacDuff, Tiffany A. Reese, Megan T. Baldridge, Jacqueline M. Kimmey, Leslie A. Weiss, Christina Song, Timothy J. Nice, Javier Carrero, Marco Colonna, Brian T. Edelson, David Sibley, Christina L. Stallings, Jean-Laurent Casanova, Kazuhiro Iwai, Skip Virgin Donna Alexandra MacDuff, Tiffany A. Reese, Megan T. Baldridge, Jacqueline M. Kimmey, Leslie A. Weiss, Christina Song, Timothy J. Nice, Javier Carrero, Marco Colonna, Brian T. Edelson, David Sibley, Christina L. Stallings, Jean-Laurent Casanova, Kazuhiro Iwai, Skip Virgin Donna Alexandra MacDuff, Tiffany A. Reese, Megan T. Baldridge, Jacqueline M. Kimmey, Leslie A. Weiss, Christina Song, Timothy J. Nice, Javier Carrero, Marco Colonna, Brian T. Edelson, David Sibley, Christina L. Stallings, Jean-Laurent Casanova, Kazuhiro Iwai, Skip Virgin Regulation of Inflammation, Innate Immunity and Intestinal Homeostasis by HOIL1 Regulation of Inflammation, Innate Immunity and Intestinal Homeostasis by HOIL1 Regulation of Inflammation, Innate Immunity and Intestinal Homeostasis by HOIL1 FASEB JOURNAL, 31 FASEB JOURNAL, 31 FASEB JOURNAL, 31 2017/04 English Summary of the papers read (international conference) Disclose to all
中澤 世識, 及川 大輔, 石井 亮平, 綾木 孝, 高橋 宏隆, 竹田 浩之, 石谷 隆一郎, 亀井 希代子, 竹吉 泉, 川上 秀史, 岩井 一宏, 畑田 出穂, 澤崎 達也, 伊東 秀文, 濡木 理, 徳永 文稔 中澤 世識, 及川 大輔, 石井 亮平, 綾木 孝, 高橋 宏隆, 竹田 浩之, 石谷 隆一郎, 亀井 希代子, 竹吉 泉, 川上 秀史, 岩井 一宏, 畑田 出穂, 澤崎 達也, 伊東 秀文, 濡木 理, 徳永 文稔 中澤 世識, 及川 大輔, 石井 亮平, 綾木 孝, 高橋 宏隆, 竹田 浩之, 石谷 隆一郎, 亀井 希代子, 竹吉 泉, 川上 秀史, 岩井 一宏, 畑田 出穂, 澤崎 達也, 伊東 秀文, 濡木 理, 徳永 文稔 Optineurin遺伝子変異に伴うALS発症における直鎖状ポリユビキチン鎖の寄与 Optineurin遺伝子変異に伴うALS発症における直鎖状ポリユビキチン鎖の寄与 Optineurin遺伝子変異に伴うALS発症における直鎖状ポリユビキチン鎖の寄与 大阪市医学会雑誌, 65, 49-50 大阪市医学会雑誌, 65, 49-50 大阪市医学会雑誌, 65, 49-50 2016/12 Japanese Disclose to all
清水 覚司, 藤田 宏明, 岩井 一宏 清水 覚司, 藤田 宏明, 岩井 一宏 清水 覚司, 藤田 宏明, 岩井 一宏 ユビキチンシステムが切り開く新たな生命現象 LUBACアクセサリー分子SHARPINとHOIL-1Lがプログラム細胞死抑制において果たす機能的差異の解析 ユビキチンシステムが切り開く新たな生命現象 LUBACアクセサリー分子SHARPINとHOIL-1Lがプログラム細胞死抑制において果たす機能的差異の解析 ユビキチンシステムが切り開く新たな生命現象 LUBACアクセサリー分子SHARPINとHOIL-1Lがプログラム細胞死抑制において果たす機能的差異の解析 日本生化学会大会・日本分子生物学会年会合同大会講演要旨集, 88回・38回, [1W11-p 日本生化学会大会・日本分子生物学会年会合同大会講演要旨集, 88回・38回, [1W11-p 日本生化学会大会・日本分子生物学会年会合同大会講演要旨集, 88回・38回, [1W11-p 2015/12 Japanese Disclose to all
藤田 宏明, 清水 覚司, 徳永 暉, Walinda Erik, 高木 賢治, 水島 恒裕, 栃尾 豪人, 岩井 一宏 藤田 宏明, 清水 覚司, 徳永 暉, Walinda Erik, 高木 賢治, 水島 恒裕, 栃尾 豪人, 岩井 一宏 藤田 宏明, 清水 覚司, 徳永 暉, Walinda Erik, 高木 賢治, 水島 恒裕, 栃尾 豪人, 岩井 一宏 LUBACリガーゼ形成における相同性の高いHOIL-1L、SHARPINのUBLの機能的差異 LUBACリガーゼ形成における相同性の高いHOIL-1L、SHARPINのUBLの機能的差異 LUBACリガーゼ形成における相同性の高いHOIL-1L、SHARPINのUBLの機能的差異 日本生化学会大会・日本分子生物学会年会合同大会講演要旨集, 88回・38回, [2P0452]-[2P0452] 日本生化学会大会・日本分子生物学会年会合同大会講演要旨集, 88回・38回, [2P0452]-[2P0452] 日本生化学会大会・日本分子生物学会年会合同大会講演要旨集, 88回・38回, [2P0452]-[2P0452] 2015/12 Japanese Disclose to all
徳永文稔, 西増弘志, 石谷隆一郎, 後藤栄治, 野口拓也, 岩井一宏, 濡木理 徳永文稔, 西増弘志, 石谷隆一郎, 後藤栄治, 野口拓也, 岩井一宏, 濡木理 徳永文稔, 西増弘志, 石谷隆一郎, 後藤栄治, 野口拓也, 岩井一宏, 濡木理 A20の直鎖状ポリユビキチン鎖特異的結合を介したNF‐kappaB制御 A20の直鎖状ポリユビキチン鎖特異的結合を介したNF‐kappaB制御 A20の直鎖状ポリユビキチン鎖特異的結合を介したNF‐kappaB制御 日本生化学会大会(Web), 85th, 3S10-3 (WEB ONLY) 日本生化学会大会(Web), 85th, 3S10-3 (WEB ONLY) 日本生化学会大会(Web), 85th, 3S10-3 (WEB ONLY) 2012 Japanese Disclose to all
浅野 剛史, 小松 雅明, 水島 昇, 岩井 一宏 浅野 剛史, 小松 雅明, 水島 昇, 岩井 一宏 浅野 剛史, 小松 雅明, 水島 昇, 岩井 一宏 細胞質の鉄貯蔵たんぱく質フェリチンに貯蔵された鉄の運命 細胞質の鉄貯蔵たんぱく質フェリチンに貯蔵された鉄の運命 細胞質の鉄貯蔵たんぱく質フェリチンに貯蔵された鉄の運命 日本生化学会大会・日本分子生物学会年会合同大会講演要旨集, 83回・33回, 4P-0605 日本生化学会大会・日本分子生物学会年会合同大会講演要旨集, 83回・33回, 4P-0605 日本生化学会大会・日本分子生物学会年会合同大会講演要旨集, 83回・33回, 4P-0605 2010/12 Japanese Disclose to all
森戸大介, 平尾和義, 細川暢子, 徳永文稔, 田中啓二, 岩井一宏, 永田和宏 森戸大介, 平尾和義, 細川暢子, 徳永文稔, 田中啓二, 岩井一宏, 永田和宏 小胞体膜貫通型ユビキチンリガーゼ gp78 のE4 活性による変異型CFTR のユビキチン化 小胞体膜貫通型ユビキチンリガーゼ gp78 のE4 活性による変異型CFTR のユビキチン化 第1 回臨床ストレス応答学会大会,京都市,2006.11.22 -23 第1 回臨床ストレス応答学会大会,京都市,2006.11.22 -23 2006 Refereed Japanese Disclose to all
吉田 雪子, 川崎 博史, 岩井 一宏, 千葉 智樹, 鈴木 俊顕, 松岡 浩司, 田中 啓二, 田井 直 吉田 雪子, 川崎 博史, 岩井 一宏, 千葉 智樹, 鈴木 俊顕, 松岡 浩司, 田中 啓二, 田井 直 吉田 雪子, 川崎 博史, 岩井 一宏, 千葉 智樹, 鈴木 俊顕, 松岡 浩司, 田中 啓二, 田井 直 N型糖鎖を認識するユビキチンリガーゼ N型糖鎖を認識するユビキチンリガーゼ N型糖鎖を認識するユビキチンリガーゼ 生化学, 73, 8, 696-696 生化学, 73, 8, 696-696 生化学, 73, 8, 696-696 2001/08 Japanese Disclose to all
K. Iwai, K. Yamanaka, T. Kamura, N. Minato, R.C. Conaway, J.W. Conaway, R.D. Klausner, A. Pause K. Iwai, K. Yamanaka, T. Kamura, N. Minato, R.C. Conaway, J.W. Conaway, R.D. Klausner, A. Pause K. Iwai, K. Yamanaka, T. Kamura, N. Minato, R.C. Conaway, J.W. Conaway, R.D. Klausner, A. Pause Identification of the von Hippel-Lindau tumor-suppressor protein as part of an active E3 ubiquitin ligase complex Identification of the von Hippel-Lindau tumor-suppressor protein as part of an active E3 ubiquitin ligase complex Identification of the von Hippel-Lindau tumor-suppressor protein as part of an active E3 ubiquitin ligase complex Proceedings of the National Academy of Sciences of the United States of America, 96, 22, 12436-12441 Proceedings of the National Academy of Sciences of the United States of America, 96, 22, 12436-12441 Proceedings of the National Academy of Sciences of the United States of America, 96, 22, 12436-12441 1999 Refereed English Disclose to all
K. Iwai, S.K. Drake, N.B. Wehr, A.M. Weissman, T. LaVaute, N. Minato, R.D. Klausner, R.L. Levine, T.A. Rouault K. Iwai, S.K. Drake, N.B. Wehr, A.M. Weissman, T. LaVaute, N. Minato, R.D. Klausner, R.L. Levine, T.A. Rouault K. Iwai, S.K. Drake, N.B. Wehr, A.M. Weissman, T. LaVaute, N. Minato, R.D. Klausner, R.L. Levine, T.A. Rouault Iron-dependent oxidation, ubiquitination, and degradation of iron regulatory protein 2: Implications for degradation of oxidized proteins Iron-dependent oxidation, ubiquitination, and degradation of iron regulatory protein 2: Implications for degradation of oxidized proteins Iron-dependent oxidation, ubiquitination, and degradation of iron regulatory protein 2: Implications for degradation of oxidized proteins Proceedings of the National Academy of Sciences of the United States of America, 95, 9, 4924-4928 Proceedings of the National Academy of Sciences of the United States of America, 95, 9, 4924-4928 Proceedings of the National Academy of Sciences of the United States of America, 95, 9, 4924-4928 1998 Refereed English Disclose to all
Title language:
Conference Activities & Talks
Title Title(Japanese) Title(English) Conference Conference(Japanese) Conference(English) Promotor Promotor(Japanese) Promotor(English) Date Language Assortment Disclose
Mechanisms underlying the formation and destabilization of the LUBAC ligase complex.[Invited] Mechanisms underlying the formation and destabilization of the LUBAC ligase complex. [Invited] Mechanisms underlying the formation and destabilization of the LUBAC ligase complex. [Invited] Cold Spring Harbor Asia Conference “Ubiquitin Family, Autophagy & Diseases” Cold Spring Harbor Asia Conference “Ubiquitin Family, Autophagy & Diseases” Cold Spring Harbor Asia Conference “Ubiquitin Family, Autophagy & Diseases” 2018/04 English Oral presentation(invited, special) Disclose to all
Linear ubiquitin chains: NF-kappaB activation, cell death, and oncogenesis[Invited] Linear ubiquitin chains: NF-kappaB activation, cell death, and oncogenesis [Invited] Linear ubiquitin chains: NF-kappaB activation, cell death, and oncogenesis [Invited] 2017 International protein metabolism and disease conference 2017 International protein metabolism and disease conference 2017 International protein metabolism and disease conference 2017/07 English Oral presentation(invited, special) Disclose to all
Differential involvement of subunits of LUBAC ubiquitin ligase in signalling and cell death. Differential involvement of subunits of LUBAC ubiquitin ligase in signalling and cell death. Differential involvement of subunits of LUBAC ubiquitin ligase in signalling and cell death. EMBO Conference “Ubiquitin and ubiquitin-like modifiers: From molecular mechanisms to human diseases EMBO Conference “Ubiquitin and ubiquitin-like modifiers: From molecular mechanisms to human diseases EMBO Conference “Ubiquitin and ubiquitin-like modifiers: From molecular mechanisms to human diseases 2015/09 English Oral presentation(general) Disclose to all
Linear ubiquitin chains: NF-kappaB activation, cell death, and cancer.[Invited] Linear ubiquitin chains: NF-kappaB activation, cell death, and cancer. [Invited] Linear ubiquitin chains: NF-kappaB activation, cell death, and cancer. [Invited] International Symposium on Ubiquitin and Diseases. International Symposium on Ubiquitin and Diseases. International Symposium on Ubiquitin and Diseases. 2015/06 English Oral presentation(invited, special) Disclose to all
Linear ubiquitin chains: a new regulator of NF-kappaB activation and cell death signaling.[Invited] Linear ubiquitin chains: a new regulator of NF-kappaB activation and cell death signaling. [Invited] Linear ubiquitin chains: a new regulator of NF-kappaB activation and cell death signaling. [Invited] 1st SPS International Symposium Xiamen University 1st SPS International Symposium Xiamen University 1st SPS International Symposium Xiamen University 2015/06 English Oral presentation(invited, special) Disclose to all
Inhibition of LUBAC-mediated linear ubiquitination by a virulence factor of Aspergillus, gliotoxin Inhibition of LUBAC-mediated linear ubiquitination by a virulence factor of Aspergillus, gliotoxin Inhibition of LUBAC-mediated linear ubiquitination by a virulence factor of Aspergillus, gliotoxin Cold Spring Harbor Laboratory meeting “The Ubiquitin Family” Cold Spring Harbor Laboratory meeting “The Ubiquitin Family” Cold Spring Harbor Laboratory meeting “The Ubiquitin Family” 2015/04 English Oral presentation(general) Disclose to all
Phenotypical difference between mice lacking subunits of LUBAC ubiquitin ligase.[Invited] Phenotypical difference between mice lacking subunits of LUBAC ubiquitin ligase. [Invited] Phenotypical difference between mice lacking subunits of LUBAC ubiquitin ligase. [Invited] 1st International Symposium for New Aspects of the Ubiquitin Research 1st International Symposium for New Aspects of the Ubiquitin Research 1st International Symposium for New Aspects of the Ubiquitin Research 2014/11 English Oral presentation(invited, special) Disclose to all
Induction of expression of linear ubiquitin chain generating LUBAC ligase and amelioration of dermatitis in cpdm mice by interferons. Induction of expression of linear ubiquitin chain generating LUBAC ligase and amelioration of dermatitis in cpdm mice by interferons. Induction of expression of linear ubiquitin chain generating LUBAC ligase and amelioration of dermatitis in cpdm mice by interferons. The EMBO conference “Ubiquitin & ubiquitin-like proteins: At the crossroads from chromatin to protein” The EMBO conference “Ubiquitin & ubiquitin-like proteins: At the crossroads from chromatin to protein” The EMBO conference “Ubiquitin & ubiquitin-like proteins: At the crossroads from chromatin to protein” 2014/10 English Oral presentation(general) Disclose to all
Linear ubiquitination : a new regulator of NF-kappaB and cell death signaling.[Invited] Linear ubiquitination : a new regulator of NF-kappaB and cell death signaling. [Invited] Linear ubiquitination : a new regulator of NF-kappaB and cell death signaling. [Invited] 2014 International Conference on Protein Metabolism & Diseases 2014 International Conference on Protein Metabolism & Diseases 2014 International Conference on Protein Metabolism & Diseases 2014/07 English Oral presentation(invited, special) Disclose to all
Molecular mechanism and regulation of linear chain-mediated NF-B activation.[Invited] Molecular mechanism and regulation of linear chain-mediated NF-B activation. [Invited] Molecular mechanism and regulation of linear chain-mediated NF-B activation. [Invited] Cold Spring Harbor Asia Conference “ Protein Modifications & Homeostasis” Cold Spring Harbor Asia Conference “ Protein Modifications & Homeostasis” Cold Spring Harbor Asia Conference “ Protein Modifications & Homeostasis” 2014/06 English Oral presentation(invited, special) Disclose to all
Linear Polyubiquitination: a Crucial Regulator of NF-kappaB Activation.[Invited] Linear Polyubiquitination: a Crucial Regulator of NF-kappaB Activation. [Invited] Linear Polyubiquitination: a Crucial Regulator of NF-kappaB Activation. [Invited] THE UEHARA MEMORIAL FOUNDATION SYMPOSIUM 2014, Innovative Medicine : Basic Research and Development THE UEHARA MEMORIAL FOUNDATION SYMPOSIUM 2014, Innovative Medicine : Basic Research and Development THE UEHARA MEMORIAL FOUNDATION SYMPOSIUM 2014, Innovative Medicine : Basic Research and Development 2014/06 English Oral presentation(invited, special) Disclose to all
Increased redox-active iron induces mitochondrial damage that recruits Parkin.[Invited] Increased redox-active iron induces mitochondrial damage that recruits Parkin. [Invited] Increased redox-active iron induces mitochondrial damage that recruits Parkin. [Invited] The 17th Biennial Meeting of Society for Free Radical Research International. Symposium “Redox-Active Iron in Disease Pathology and Treatment” The 17th Biennial Meeting of Society for Free Radical Research International. Symposium “Redox-Active Iron in Disease Pathology and Treatment” The 17th Biennial Meeting of Society for Free Radical Research International. Symposium “Redox-Active Iron in Disease Pathology and Treatment” 2014/03 English Oral presentation(invited, special) Disclose to all
Differential requirement of LUBAC-mediated linear polyubiquitination in CD40- or BCR-mediated canonical NF-kappaB activation in B cells. Differential requirement of LUBAC-mediated linear polyubiquitination in CD40- or BCR-mediated canonical NF-kappaB activation in B cells. Differential requirement of LUBAC-mediated linear polyubiquitination in CD40- or BCR-mediated canonical NF-kappaB activation in B cells. The EMBO Conference “Ubiquitin and Ubiquitin-like Proteins: From structure to function” The EMBO Conference “Ubiquitin and Ubiquitin-like Proteins: From structure to function” The EMBO Conference “Ubiquitin and Ubiquitin-like Proteins: From structure to function” 2013/10 English Oral presentation(general) Disclose to all
Linear polyubiquitination: a new regulator of NF-kappaB activation.[Invited] Linear polyubiquitination: a new regulator of NF-kappaB activation. [Invited] Linear polyubiquitination: a new regulator of NF-kappaB activation. [Invited] The 38th FEBS congress symposium “Regulation of biological processes by ubiquitin and ubiquitin-like proteins in health and disease: proteolysis, autophagy and apoptosis” The 38th FEBS congress symposium “Regulation of biological processes by ubiquitin and ubiquitin-like proteins in health and disease: proteolysis, autophagy and apoptosis” The 38th FEBS congress symposium “Regulation of biological processes by ubiquitin and ubiquitin-like proteins in health and disease: proteolysis, autophagy and apoptosis” 2013/07 English Oral presentation(invited, special) Disclose to all
Linear polyubiquitination : A crucial regulator of NF-kappaB signaling.[Invited] Linear polyubiquitination : A crucial regulator of NF-kappaB signaling. [Invited] Linear polyubiquitination : A crucial regulator of NF-kappaB signaling. [Invited] The 3rd International Symposium "Signaling and Regulation in the Immune and Nervous Systems“ The 3rd International Symposium "Signaling and Regulation in the Immune and Nervous Systems“ The 3rd International Symposium "Signaling and Regulation in the Immune and Nervous Systems“ 2012/11 English Oral presentation(invited, special) Disclose to all
Linear polyubiquitination: A crucial regulator of NF-kappaB signalling[Invited] Linear polyubiquitination: A crucial regulator of NF-kappaB signalling [Invited] Linear polyubiquitination: A crucial regulator of NF-kappaB signalling [Invited] ZOMESVII conference ZOMESVII conference ZOMESVII conference 2012/09 English Oral presentation(invited, special) Disclose to all
Mechanism underlying generation of linear polyubiquitin chains.[Invited] Mechanism underlying generation of linear polyubiquitin chains. [Invited] Mechanism underlying generation of linear polyubiquitin chains. [Invited] 4th Annual Ubiquitin Drug Discovery & Diagnostics Conference 2012 4th Annual Ubiquitin Drug Discovery & Diagnostics Conference 2012 4th Annual Ubiquitin Drug Discovery & Diagnostics Conference 2012 2012/07 English Oral presentation(invited, special) Disclose to all
Linear polyubiquitination: a regulator of NF-kappaB activation.[Invited] Linear polyubiquitination: a regulator of NF-kappaB activation. [Invited] Linear polyubiquitination: a regulator of NF-kappaB activation. [Invited] FASEB Summer Research Conferences “Ubiquitin & Cellular Regulation” FASEB Summer Research Conferences “Ubiquitin & Cellular Regulation” FASEB Summer Research Conferences “Ubiquitin & Cellular Regulation” 2012/06 English Oral presentation(invited, special) Disclose to all
Linear polyubiquitination : A crucial regulator of NF-kappaB signaling.[Invited] Linear polyubiquitination : A crucial regulator of NF-kappaB signaling. [Invited] Linear polyubiquitination : A crucial regulator of NF-kappaB signaling. [Invited] Keystone Symposium “NF-B signaling and Biology: From Bench to Bedside” and “Ubiquitin Signaling” Keystone Symposium “NF-kappaB signaling and Biology: From Bench to Bedside” and “Ubiquitin Signaling” Keystone Symposium “NF-B signaling and Biology: From Bench to Bedside” and “Ubiquitin Signaling” 2012/03 English Oral presentation(invited, special) Disclose to all
Linear polyubiquitination : A new regulator of NF-kappaB activation.[Invited] Linear polyubiquitination : A new regulator of NF-kappaB activation. [Invited] Linear polyubiquitination : A new regulator of NF-kappaB activation. [Invited] The EMBO Conference “Ubiquitin and Ubiquitin-like Modifiers: From functional modules to system biology The EMBO Conference “Ubiquitin and Ubiquitin-like Modifiers: From functional modules to system biology The EMBO Conference “Ubiquitin and Ubiquitin-like Modifiers: From functional modules to system biology 2011/09 English Oral presentation(invited, special) Disclose to all
Linear polyubiquitination: a new regulator of NF-kappaB signaling.[Invited] Linear polyubiquitination: a new regulator of NF-kappaB signaling. [Invited] Linear polyubiquitination: a new regulator of NF-kappaB signaling. [Invited] Banbury Center meetings, “SIGNALING THROUGH UBIQUITIN” Banbury Center meetings, “SIGNALING THROUGH UBIQUITIN” Banbury Center meetings, “SIGNALING THROUGH UBIQUITIN” 2010/11 English Oral presentation(invited, special) Disclose to all
Dissection of intracellular heme transport mechanism using a baker’s yeast, Saccharomyces cerevisiae.[Invited] Dissection of intracellular heme transport mechanism using a baker’s yeast, Saccharomyces cerevisiae. [Invited] Dissection of intracellular heme transport mechanism using a baker’s yeast, Saccharomyces cerevisiae. [Invited] JSH International Symposium 2010 in Akita, Seven Wonders of Erythropoiesis JSH International Symposium 2010 in Akita, Seven Wonders of Erythropoiesis JSH International Symposium 2010 in Akita, Seven Wonders of Erythropoiesis 2010/07 English Oral presentation(invited, special) Disclose to all
Linear polyubiquitination: a new regulator of NF-kappaB signaling.[Invited] Linear polyubiquitination: a new regulator of NF-kappaB signaling. [Invited] Linear polyubiquitination: a new regulator of NF-kappaB signaling. [Invited] FASEB Summer Research Conferences “Ubiquitin and Cellular Regulation” FASEB Summer Research Conferences “Ubiquitin and Cellular Regulation” FASEB Summer Research Conferences “Ubiquitin and Cellular Regulation” 2010/06 English Oral presentation(invited, special) Disclose to all
Linear Polyubiquitination: A Newly Identified Regulator of NF-kB Signaling.[Invited] Linear Polyubiquitination: A Newly Identified Regulator of NF-kB Signaling. [Invited] Linear Polyubiquitination: A Newly Identified Regulator of NF-kB Signaling. [Invited] “BIOLOGY OF THE UBIQUITIN AND THE UBIQUITIN-LIKE SYSTEMS” Research Conference of the Institute for Advanced Studies, the Israel Science Foundation. “BIOLOGY OF THE UBIQUITIN AND THE UBIQUITIN-LIKE SYSTEMS” Research Conference of the Institute for Advanced Studies, the Israel Science Foundation. “BIOLOGY OF THE UBIQUITIN AND THE UBIQUITIN-LIKE SYSTEMS” Research Conference of the Institute for Advanced Studies, the Israel Science Foundation. 2010/03 English Oral presentation(invited, special) Disclose to all
Linear polyubiquitination : A newly identified regulator of NF-kappaB signaling. Linear polyubiquitination : A newly identified regulator of NF-kappaB signaling. Linear polyubiquitination : A newly identified regulator of NF-kappaB signaling. Keystone Symposium “NF-kappaB in Inflammation and Disease” Keystone Symposium “NF-kappaB in Inflammation and Disease” Keystone Symposium “NF-kappaB in Inflammation and Disease” 2010/01 English Oral presentation(general) Disclose to all
Linear polyubiquitination : A newly identified regulator of NF-kappaB signaling.[Invited] Linear polyubiquitination : A newly identified regulator of NF-kappaB signaling. [Invited] Linear polyubiquitination : A newly identified regulator of NF-kappaB signaling. [Invited] The EMBO Conference “Ubiquitin and Ubiquitin-like Modifiers in Cellular Regulation” The EMBO Conference “Ubiquitin and Ubiquitin-like Modifiers in Cellular Regulation” The EMBO Conference “Ubiquitin and Ubiquitin-like Modifiers in Cellular Regulation” 2009/09 English Oral presentation(invited, special) Disclose to all
Involvement of linear polyubiquitination of NEMO in NF-kappaB activation. Involvement of linear polyubiquitination of NEMO in NF-kappaB activation. Involvement of linear polyubiquitination of NEMO in NF-kappaB activation. Cold Spring Harbor Laboratory meeting “The Ubiquitin Family” Cold Spring Harbor Laboratory meeting “The Ubiquitin Family” Cold Spring Harbor Laboratory meeting “The Ubiquitin Family” 2009/04 English Oral presentation(general) Disclose to all
Physiological Function of Linear Polyubiquitin Chain.[Invited] Physiological Function of Linear Polyubiquitin Chain. [Invited] Physiological Function of Linear Polyubiquitin Chain. [Invited] Keystone Symposium “The Many Faces of Ubiquitin” Keystone Symposium “The Many Faces of Ubiquitin” Keystone Symposium “The Many Faces of Ubiquitin” 2009/01 English Oral presentation(invited, special) Disclose to all
Prevention of TNF-alpha induced apoptosis by linear polyubiquitination.[Invited] Prevention of TNF-alpha induced apoptosis by linear polyubiquitination. [Invited] Prevention of TNF-alpha induced apoptosis by linear polyubiquitination. [Invited] Takeda Science Foundation Symposium on Bioscience “Cell Death: What have we learned and what will we learn?” Takeda Science Foundation Symposium on Bioscience “Cell Death: What have we learned and what will we learn?” Takeda Science Foundation Symposium on Bioscience “Cell Death: What have we learned and what will we learn?” 2008/12 English Oral presentation(invited, special) Disclose to all
The COP9/Signalosome increases the efficiency of pVHL-containing ubiquitin ligase–mediated HIF-alpha ubiquitination.[Invited] The COP9/Signalosome increases the efficiency of pVHL-containing ubiquitin ligase–mediated HIF-alpha ubiquitination. [Invited] The COP9/Signalosome increases the efficiency of pVHL-containing ubiquitin ligase–mediated HIF-alpha ubiquitination. [Invited] ZOMESV: The Fifth International Symposium on the COP9 signalosome, Proteasome and eIF3: At the interface between signaling and proteolysis ZOMESV: The Fifth International Symposium on the COP9 signalosome, Proteasome and eIF3: At the interface between signaling and proteolysis ZOMESV: The Fifth International Symposium on the COP9 signalosome, Proteasome and eIF3: At the interface between signaling and proteolysis 2008/11 English Oral presentation(invited, special) Disclose to all
Disturbed heme metabolism in the liver of fatigue model rats and its involvement of fatigue.[Invited] Disturbed heme metabolism in the liver of fatigue model rats and its involvement of fatigue. [Invited] Disturbed heme metabolism in the liver of fatigue model rats and its involvement of fatigue. [Invited] The International Conference on Fatigue Science The International Conference on Fatigue Science The International Conference on Fatigue Science 2008/09 English Oral presentation(invited, special) Disclose to all
Involvement of the mitochondrial Fe-S cluster biogenetic system in the regulation of cellular iron metabolism.[Invited] Involvement of the mitochondrial Fe-S cluster biogenetic system in the regulation of cellular iron metabolism. [Invited] Involvement of the mitochondrial Fe-S cluster biogenetic system in the regulation of cellular iron metabolism. [Invited] 3nd International Workshop on Cell Regulations in Division and Arrest under Stress 3nd International Workshop on Cell Regulations in Division and Arrest under Stress 3nd International Workshop on Cell Regulations in Division and Arrest under Stress 2008/04 English Oral presentation(invited, special) Disclose to all
Mechanism underlying the iron-dependent regulation of the iron-sensing transcription factor Aft1p in Saccharomyces cerevisiae.[Invited] Mechanism underlying the iron-dependent regulation of the iron-sensing transcription factor Aft1p in Saccharomyces cerevisiae. [Invited] Mechanism underlying the iron-dependent regulation of the iron-sensing transcription factor Aft1p in Saccharomyces cerevisiae. [Invited] Okazaki Conference Molecular Science and Chemical Biology of Biomolecular Function Okazaki Conference Molecular Science and Chemical Biology of Biomolecular Function Okazaki Conference Molecular Science and Chemical Biology of Biomolecular Function 2007/11 English Oral presentation(invited, special) Disclose to all
Linear ubiquitination of NEMO triggers NF-kappaB activation. Linear ubiquitination of NEMO triggers NF-kappaB activation. Linear ubiquitination of NEMO triggers NF-kappaB activation. The EMBO Conference “Ubiquitin and Ubiquitin-like Modifiers in Cellular Regulation” The EMBO Conference “Ubiquitin and Ubiquitin-like Modifiers in Cellular Regulation” The EMBO Conference “Ubiquitin and Ubiquitin-like Modifiers in Cellular Regulation” 2007/09 English Oral presentation(general) Disclose to all
Identification of a ligase complex polymerizing linear polyubiquitin chains and its physiological role.[Invited] Identification of a ligase complex polymerizing linear polyubiquitin chains and its physiological role. [Invited] Identification of a ligase complex polymerizing linear polyubiquitin chains and its physiological role. [Invited] The Fourth NIBB-EMBL Symposium The Fourth NIBB-EMBL Symposium The Fourth NIBB-EMBL Symposium 2006/12 English Oral presentation(invited, special) Disclose to all
Involvement of heme regulatory motif in iron-sensing, ubiquitination and degradation of IRP2[Invited] Involvement of heme regulatory motif in iron-sensing, ubiquitination and degradation of IRP2 [Invited] Involvement of heme regulatory motif in iron-sensing, ubiquitination and degradation of IRP2 [Invited] Symposium in EABS & 44th Annual Meeting of the Biophysical Society of Japan Symposium in EABS & 44th Annual Meeting of the Biophysical Society of Japan Symposium in EABS & 44th Annual Meeting of the Biophysical Society of Japan 2006/11 English Oral presentation(invited, special) Disclose to all
Involvement of Heme Regulatory Motif in Iron-sensing, Ubiquitination and Degradation of IRP2.[Invited] Involvement of Heme Regulatory Motif in Iron-sensing, Ubiquitination and Degradation of IRP2. [Invited] Involvement of Heme Regulatory Motif in Iron-sensing, Ubiquitination and Degradation of IRP2. [Invited] The 20th IUBMB The 20th IUBMB The 20th IUBMB 2006/06 English Oral presentation(general) Disclose to all
Mechanism underlying oxidation-induced ubiquitylation.[Invited] Mechanism underlying oxidation-induced ubiquitylation. [Invited] Mechanism underlying oxidation-induced ubiquitylation. [Invited] The Hebrew University of Jerusalem, The Institute for Advances Studies Workshop “Ubiquitin in Cancer and in Chronic Diseases” The Hebrew University of Jerusalem, The Institute for Advances Studies Workshop “Ubiquitin in Cancer and in Chronic Diseases” The Hebrew University of Jerusalem, The Institute for Advances Studies Workshop “Ubiquitin in Cancer and in Chronic Diseases” 2004/05 English Oral presentation(invited, special) Disclose to all
Identification of HOIL-1 ubiquitin ligase that recognizes Heme Oxidized IRP2.[Invited] Identification of HOIL-1 ubiquitin ligase that recognizes Heme Oxidized IRP2. [Invited] Identification of HOIL-1 ubiquitin ligase that recognizes Heme Oxidized IRP2. [Invited] 3rd General Meeting of the International Proteolytic Society. 3rd General Meeting of the International Proteolytic Society. 3rd General Meeting of the International Proteolytic Society. 2003/11 English Oral presentation(invited, special) Disclose to all
Identification of the ubiquitin-protein ligase that recognizes heme-oxidized IRP2 Identification of the ubiquitin-protein ligase that recognizes heme-oxidized IRP2 Identification of the ubiquitin-protein ligase that recognizes heme-oxidized IRP2 World Congress on Iron Metabolism World Congress on Iron Metabolism World Congress on Iron Metabolism 2003/05 English Oral presentation(general) Disclose to all
Identification of the ubiquitin-protein ligase that recognized oxidized IRP2. Identification of the ubiquitin-protein ligase that recognized oxidized IRP2. Identification of the ubiquitin-protein ligase that recognized oxidized IRP2. Cold Spring Harbor Laboratory Symposium “Ubiquitin family” Cold Spring Harbor Laboratory Symposium “Ubiquitin family” Cold Spring Harbor Laboratory Symposium “Ubiquitin family” 2003/04 English Oral presentation(general) Disclose to all
Identification of an ubiquitin-protein ligase recognizing oxidized proteins.[Invited] Identification of an ubiquitin-protein ligase recognizing oxidized proteins. [Invited] Identification of an ubiquitin-protein ligase recognizing oxidized proteins. [Invited] The 3rd International Symposium on Autophagy The 3rd International Symposium on Autophagy The 3rd International Symposium on Autophagy 2002/09 English Oral presentation(invited, special) Disclose to all
Isolation of the candidate of E3, which recognizes oxidized IRP2 Isolation of the candidate of E3, which recognizes oxidized IRP2 Isolation of the candidate of E3, which recognizes oxidized IRP2 FASEB summer research conference ”Ubiquitin and intracellular protein degradation” FASEB summer research conference ”Ubiquitin and intracellular protein degradation” FASEB summer research conference ”Ubiquitin and intracellular protein degradation” 2001/06 English Oral presentation(general) Disclose to all
Identification of the von Hippel-Lindau tumor suppressor protein as part of an active E3 ubiquitin ligase complex[Invited] Identification of the von Hippel-Lindau tumor suppressor protein as part of an active E3 ubiquitin ligase complex [Invited] Identification of the von Hippel-Lindau tumor suppressor protein as part of an active E3 ubiquitin ligase complex [Invited] The EMBO workshop "ubiquitin-proteasome pathway and cellular regulation" The EMBO workshop "ubiquitin-proteasome pathway and cellular regulation" The EMBO workshop "ubiquitin-proteasome pathway and cellular regulation" 2000/05 English Oral presentation(invited, special) Disclose to all
Oxidation-induced ubiquitination of iron regulatory protein 2: Implications for degradation of oxidized proteins.[Invited] Oxidation-induced ubiquitination of iron regulatory protein 2: Implications for degradation of oxidized proteins. [Invited] Oxidation-induced ubiquitination of iron regulatory protein 2: Implications for degradation of oxidized proteins. [Invited] The 6th CGGH symposium The 6th CGGH symposium The 6th CGGH symposium 1999/05 English Disclose to all
Oxidative modification is the signal of the iron-dependent degradation of iron regulatory protein 2 (IRP2) via uhiquitin proteasome pathway. Oxidative modification is the signal of the iron-dependent degradation of iron regulatory protein 2 (IRP2) via uhiquitin proteasome pathway. Oxidative modification is the signal of the iron-dependent degradation of iron regulatory protein 2 (IRP2) via uhiquitin proteasome pathway. FASEB summer reserch conference ”Ubiquitin and protein degradation” FASEB summer reserch conference ”Ubiquitin and protein degradation” FASEB summer reserch conference ”Ubiquitin and protein degradation” 1997/06 English Oral presentation(general) Disclose to all
Iron dependent degradation of a second iron-responsive element binding protein, IRP2(iron regulatory protein 2): implication of ubiquitin system. Iron dependent degradation of a second iron-responsive element binding protein, IRP2(iron regulatory protein 2): implication of ubiquitin system. Iron dependent degradation of a second iron-responsive element binding protein, IRP2(iron regulatory protein 2): implication of ubiquitin system. FASEB summer research conference”Ubiquitin and protein degradation” FASEB summer research conference”Ubiquitin and protein degradation” FASEB summer research conference”Ubiquitin and protein degradation” 1995/06 English Oral presentation(general) Disclose to all

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Title language:
Industrial Property Rights (Patent)
Inventor(s) Inventor(s) (Japanese) Inventor(s) (English) Title Title(Japanese) Title(English) Stage Patent number Date Disclose
IWAI Kazuhiro 岩井 一宏 IWAI Kazuhiro UBIQUITIN LIGASE HAVING LINEAR POLYUBIQUITINATIONACTIVITY AND USE THEREOF UBIQUITIN LIGASE HAVING LINEAR POLYUBIQUITINATIONACTIVITY AND USE THEREOF UBIQUITIN LIGASE HAVING LINEAR POLYUBIQUITINATIONACTIVITY AND USE THEREOF 特許公表 特表217972 2015/12/25 Disclose to all
IWAI Kazuhiro 岩井 一宏 IWAI Kazuhiro UBIQUITIN LIGASE AND USE THEREOF UBIQUITIN LIGASE AND USE THEREOF UBIQUITIN LIGASE AND USE THEREOF 特許登録 特許8,56,094 B2 2013/10/01 Disclose to all
岩井 一宏 岩井 一宏 新規なユビキチンリガーゼおよびその利用 新規なユビキチンリガーゼおよびその利用 特許登録 特許5234865 2013/04/05 Disclose to all
池田 恭治, 石井 晴朗, 岩井 一宏, 伊東 昌子 池田 恭治, 石井 晴朗, 岩井 一宏, 伊東 昌子 破骨細胞制御剤とそのスクリーニング方法 破骨細胞制御剤とそのスクリーニング方法 特許出願 特願2007-151307 2007/06 Disclose to all
Title language:
Awards
Title(Japanese) Title(English) Organization name(Japanese) Organization name(English) Date
日本医師会医学賞 Medical Award of The Japan Medical Association 日本医師会 The Japan Medical Association 2015/11/01
持田記念学術賞 Academic Award of the Mochida Memorial Foundation 持田記念医学薬学振興財団 Mochida Memorial Foundation for Medical and Pharmaceutical Research 2017/11/09
武田医学賞 Takeda Medical Prize 武田科学振興財団 Takeda Science Foundation 2019/11/12
上原賞 Uehara Prize 上原記念生命科学財団 The Uehara Memorial Foundation 2020/03/11
External funds: competitive funds and Grants-in-Aid for Scientific Research (Kakenhi)
Type Position Title(Japanese) Title(English) Period
挑戦的萌芽研究 Representative NF-κB活性化を制御するユビキチンリガーゼ活性調節薬の開発 2012-2013
新学術領域研究(研究領域提案型) Representative ユビキチンネオバイオロジー:拡大するタンパク質制御システム 2012-2016
新学術領域研究(研究領域提案型) Representative 直鎖状ポリユビキチン鎖の選択的生成機構とその役割 2012-2016
新学術領域研究(研究領域提案型) Representative ユビキチンネオバイオロジー:拡大するタンパク質制御システム 2012/04/01-2017/03/31
新学術領域研究(研究領域提案型) Representative 直鎖状ポリユビキチン鎖の選択的生成機構とその役割 2012/04/01-2017/03/31
基盤研究(A) Representative 直鎖状ポリユビキチン鎖生成リガーゼの機能とその異常による疾患発症機構 2013-2015
挑戦的萌芽研究 Representative NF-κBを制御する直鎖状ユビキチン鎖生成調節薬の開発 (平成26年度分) 2014/04/01-2015/03/31
新学術領域研究(研究領域提案型) Representative 直鎖状ポリユビキチン鎖の選択的生成機構とその役割 (平成26年度分) 2014/04/01-2015/03/31
新学術領域研究(研究領域提案型) Representative 直鎖状ポリユビキチン鎖の選択的生成機構とその役割 (平成26年度分) 2014/04/01-2015/03/31
新学術領域研究(研究領域提案型) Representative ユビキチンネオバイオロジー:拡大するタンパク質制御システム (平成26年度分) 2014/04/01-2015/03/31
基盤研究(A) Representative 直鎖状ポリユビキチン鎖生成リガーゼの機能とその異常による疾患発症機構 (平成26年度分) 2014/04/01-2015/03/31
基盤研究(A) Representative 直鎖状ポリユビキチン鎖生成リガーゼの機能とその異常による疾患発症機構 (平成27年度分) 2015/04/01-2016/03/31
新学術領域研究(研究領域提案型) Representative ユビキチンネオバイオロジー:拡大するタンパク質制御システム (平成27年度分) 2015/04/01-2016/03/31
新学術領域研究(研究領域提案型) Representative 直鎖状ポリユビキチン鎖の選択的生成機構とその役割 (平成27年度分) 2015/04/01-2016/03/31
基盤研究(A) Representative 直鎖状ポリユビキチン鎖生成リガーゼの機能とその異常による疾患発症機構 (平成27年度分) 2015/04/01-2016/03/31
挑戦的萌芽研究 Representative NF-κBを制御する直鎖状ユビキチン鎖生成調節薬の開発 (平成27年度分) 2015/04/01-2016/03/31
新学術領域研究(研究領域提案型) Representative ユビキチンネオバイオロジー:拡大するタンパク質制御システム (平成28年度分) 2016/04/01-2017/03/31
新学術領域研究(研究領域提案型) Representative 直鎖状ポリユビキチン鎖の選択的生成機構とその役割 (平成28年度分) 2016/04/01-2017/03/31
新学術領域研究(研究領域提案型) Representative 直鎖状ポリユビキチン鎖の選択的生成機構とその役割 (平成28年度分) 2016/04/01-2017/03/31
基盤研究(A) Representative 直鎖状ポリユビキチン鎖生成リガーゼの機能とその異常による疾患発症機構 (平成28年度分) 2016/04/01-2017/03/31
基盤研究(A) Representative 直鎖状ユビキチン鎖による生体制御機構の解析 (平成29年度分) 2017/04/01-2018/03/31
基盤研究(S) Representative 直鎖状ユビキチン鎖を生成するLUBACリガーゼの統括的研究 (平成29年度分) 2017/04/01-2018/03/31
新学術領域研究(研究領域提案型) Representative ユビキチンネオバイオロジー:拡大するタンパク質制御システム (平成29年度分) 2017/04/01-2018/03/31
基盤研究(S) Representative 直鎖状ユビキチン鎖を生成するLUBACリガーゼの統括的研究 (平成30年度分) 2018/04/01-2019/03/31
新学術領域研究(研究領域提案型) Representative ケモテクノロジーを利用したユビキチン鎖の機能解析と制御 (平成30年度分) 2018/04/01-2019/03/31
基盤研究(S) Representative 直鎖状ユビキチン鎖を生成するLUBACリガーゼの統括的研究 (2019年度分) 2019/04/01-2020/03/31
新学術領域研究(研究領域提案型) Representative ケモテクノロジーを利用したユビキチン鎖の機能解析と制御 (2019年度分) 2019/04/01-2020/03/31

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Teaching subject(s)
Name(Japanese) Name(English) Term Department Period
A4ab 生理学・同実習 Physiology 後期後半 医学部 2013/04-2014/03
A4a 生理学 Physiology 後期後半 医学部 2014/04-2015/03
A4b 生理学実習 Laboratory Course in Physiology 後期後半 医学部 2014/04-2015/03
生理学 I Physiology I 後期不定 医学研究科 2014/04-2015/03
生理学 II Physiology II 後期不定 医学研究科 2014/04-2015/03
生理学 Physiology 後期不定 医学研究科 2014/04-2015/03
A4a 生理学 Physiology 後期後半 医学部 2015/04-2016/03
A4b 生理学実習 Laboratory Course in Physiology 後期後半 医学部 2015/04-2016/03
生理学 II Physiology II 後期不定 医学研究科 2015/04-2016/03
生理学 I Physiology I 後期不定 医学研究科 2015/04-2016/03
生理学 Physiology 後期不定 医学研究科 2015/04-2016/03
生理学 Physiology 後期 工学研究科 2015/04-2016/03
A4a 生理学 Physiology 後期後半 医学部 2016/04-2017/03
A4b 生理学実習 Laboratory Course in Physiology 後期後半 医学部 2016/04-2017/03
生理学 II Physiology II 後期不定 医学研究科 2016/04-2017/03
生理学 I Physiology I 後期不定 医学研究科 2016/04-2017/03
生理学 Physiology 後期不定 医学研究科 2016/04-2017/03
生理学 Physiology 後期 工学研究科 2016/04-2017/03
A4a 生理学 Physiology 後期後半 医学部 2018/04-2019/03
A4b 生理学実習 Laboratory Course in Physiology 後期後半 医学部 2018/04-2019/03
B5a 生理学 Physiology 後期前半 医学部 2018/04-2019/03
B5b 生理学実習 Laboratory Course in Physiology 後期前半 医学部 2018/04-2019/03
生理学II Physiology II 前期後半 医学部(人間健康科学科) 2018/04-2019/03
生理学 II Physiology II 後期不定 医学研究科 2018/04-2019/03
生理学 I Physiology I 後期不定 医学研究科 2018/04-2019/03
生理学 Physiology 後期不定 医学研究科 2018/04-2019/03
A4a 生理学 Physiology 後期後半 医学部 2019/04-2020/03
A4b 生理学実習 Laboratory Course in Physiology 後期後半 医学部 2019/04-2020/03
B5a 生理学 Physiology 後期前半 医学部 2019/04-2020/03
B5b 生理学実習 Laboratory Course in Physiology 後期前半 医学部 2019/04-2020/03
生理学II Physiology II 前期後半 医学部(人間健康科学科) 2019/04-2020/03
A4a 生理学 Physiology 後期後半 医学部 2020/04-2021/03
A4b 生理学実習 Laboratory Course in Physiology 後期後半 医学部 2020/04-2021/03
B5a 生理学 Physiology 後期前半 医学部 2020/04-2021/03
B5b 生理学実習 Laboratory Course in Physiology 後期前半 医学部 2020/04-2021/03

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School management (title, position)
Title Period
学生生活委員会 委員 2013/04/01-2015/03/31
奨学金返還免除候補者選考委員会 委員 2013/04/01-2015/03/31
企画委員会 委員 2016/10/01-2018/09/30
国際高等教育院 企画評価専門委員会 生物学部会 委員 2015/05/01-2017/04/30
教育研究評議会 評議員 2017/10/01-2019/03/31
医学研究科 研究科長 2018/10/01-2020/09/30
医学部 学部長 2018/10/01-2020/09/30
医学教育・国際化推進センター長 2018/10/01-2020/09/30
企画委員会 委員 2018/10/01-2020/09/30
企画委員会 若手重点戦略定員専門委員会 委員 2018/07/24-2020/09/30
京都大学情報環境整備委員会 委員 2018/10/01-2021/03/31
全学情報セキュリティ委員会 委員 2018/10/01-
国際高等教育院 教養・共通教育協議会 協議員 2018/10/01-2020/09/30
国際高等教育院 大学院共通・横断教育基盤協議会 協議員 2018/10/01-2020/09/30
京都大学スーパーグローバルコース実施運営協議会 委員 2018/10/01-2020/03/31
大学院横断教育プログラム推進センター運営協議会 協議員 2018/10/01-2020/03/31
入学試験委員会 委員 2018/10/01-2020/09/30
競争的資金等の不正防止計画推進室 室員 2019/04/01-2020/09/30
研究公正推進委員会 委員 2019/04/01-2020/09/30
研究公正委員会 委員 2018/10/01-2020/09/30
京都大学利益相反マネジメント委員会 委員 2018/10/01-2020/09/30
産学共同実用化促進事業実施委員会 委員 2018/10/01-2019/09/09
産官学連携本部運営協議会 委員 2018/10/01-2020/09/30
環境安全保健委員会 委員 2019/04/01-2021/03/31
教育研究評議会 評議員 2018/10/01-2020/09/30
部局長会議 2018/10/01-2020/09/30
研究科長部会 2018/10/01-2020/09/30
基金運営委員会 委員 2018/10/01-2020/09/30
教員活動評価委員会 委員 2018/10/01-2019/03/31
核燃料物質専門委員会 -
原子力研究整備委員会 -
情報環境整備委員会 2019/04/01-2021/03/31
創立百二十五周年記念事業委員会幹事会 2018/10/01-2020/09/30
京都大学学術研究支援室運営委員会 委員 2018/10/01-2020/03/31
京都大学研究者情報整備委員会 2018/10/01-2020/03/31
環境安全保健機構運営協議会協議員 2018/10/01-2020/06/30
全学教員部教員選考会議(環境安全保健機構)構成員 2019/02/06-
スーパーグローバルコース実施運営協議会 協議員 2018/10/01-2020/09/30
大学院横断教育プログラム推進センター運営協議会 協議員 2018/10/01-2020/09/30
京都大学研究者情報整備委員会 委員 2020/04/01-2020/09/30
京都大学利益相反マネジメント委員会 委員 2018/10/01-2022/03/31

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Faculty management (title, position)
Title Period
人事連絡委員会 2012/10/01-2020/09/30
副研究科長 2017/10/01-2019/03/31
医学図書館図書連絡委員 2013/09/01-2015/03/31
医学研究科・医学部将来計画検討委員会 2017/10/01-2020/09/30
医学研究科等防犯カメラ設置運用委員会 2013/04/01-2020/09/30
医学研究科運営委員会 -2018/03/31
管理体制委員会 2016/10/01-2018/09/30
基礎系副専攻長 2013/04/01-2015/06/10
M.D./Ph.D.コース運営委員会 2017/04/01-
大倉辰三郎・喜美奨学金 選考小委員会 2015/04/01-2018/09/30
動物実験施設管理委員会 2018/10/01-2020/09/30
学務委員会 2018/04/01-2020/09/30
寄附講座運営委員会(創薬医学) 2016/04/01-2020/03/31
寄附講座運営委員会(免疫ゲノム医学) 2016/04/01-2020/03/31
教員人事活性化委員会 2015/09/24-
再生医科学研究所運営委員会 2016/04/01-2018/03/31
病院長・評議員 2017/10/01-2019/03/31
医学研究科・医学部財務委員会 -
ウイルス・再生医科学研究所・再生医学・再生医療の先端融合的共同研究拠点運営委員会 2018/04/01-2020/03/31
医学図書館図書連絡委員 2018/04/01-2019/03/31
医学研究科長・医学部長 2018/10/01-2020/09/30
附属医学教育・国際化推進センター 2018/10/01-2020/09/30
医学教育・国際化推進センター運営委員会 -
医学図書館図書運営委員 2017/10/01-2020/09/30
放射線障害防止委員会 -
学術情報システム・情報セキュリティ委員会 2018/10/01-2020/09/30
IFOM-KU 国際共同ラボ 運営委員会 -
京都大学医薬系総合研究棟管理運営委員会 2018/10/01-2020/09/30
京都大学分子生物実験研究棟管理運営委員会 -
京都大学白眉センター運営委員会 2018/10/01-2020/09/30
京都大学白眉センター伯楽会議委員 2018/12/01-2020/06/30
大学院総合生存学館教授会(思修館協議会) 2018/10/01-2020/09/30
ウイルス・再生医科学研究所諮問会議委員 2018/02/01-2020/03/31

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Number of times you have hosted foreign researchers (short-term)
Visitor name Organization Country Date
Aaron J. Ciechanover (Nobel Prize in Chemistry 2004) Technion-Israel Institute of Technology Israel 2016/11/27-2016/12/10