高原 和彦

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Name(Kanji/Kana/Abecedarium Latinum)
高原 和彦/タカハラ カズヒコ/Takahara, Kazuhiko
Primary Affiliation(Org1/Job title)
Graduate Schools Biostudies/Associate Professor
Faculty
Org1 Job title
理学部
Contact Address
Type Address(Japanese) Address(English)
Office 〒606-8501 京都府京都市左京区吉田近衛町 Yoshida-Konoe, Sakyo, Kyoto, Kyoto 606-8501, Japan
Phone
Type Number
Office 075-753-4106
Academic Organizations You are Affiliated to in Japan
Organization name(Japanese) Organization name(English)
日本生化学会 Japanese Biochemical Society
日本免疫学会 Japanese Society for Immunology
Academic Degree
Field(Japanese) Field(English) University(Japanese) University(English) Method
工学修士 広島大学
博士(工学) 広島大学
Graduate School
University(Japanese) University(English) Faculty(Japanese) Faculty(English) Major(Japanese) Major(English) Degree
広島大学 大学院工学研究科博士課程(前期)工業化学専攻 修了
Undergraduate School / Major(s)
University(Japanese) University(English) Faculty(Japanese) Faculty(English) Major(s)(Japanese) Major(s)(English) Degree
広島大学 工学部第三類(化学系) 卒業
Work Experience
Period Organization(Japanese) Organization(English) Job title(Japanese) Job title(English)
1986-1993 1986-1993 宝酒造(株) 1986-1993 Researcher, Takara shuzo 研究員
1987-1988 1987-1988 大阪大学細胞工学センター 1987-1988 Institute for Molecular and cellular Biology, Osaka University 派遣研究員
1988-1990 国立ガンセンター研究所 1988-1990 National Cancer Center Research Institute. 派遣研究員
1993-1997 1993-1997 米国ウィスコンシン大学医学部病理学 1993-1997 Post doctoral fellow, Dep. of Pathology. University of Wisconsin ポストドクトラルフェロー
1997-1999 1997-1999 京都大学理学部 1997-1999 Graduate School of Science, Kyoto University. Instructor 助手 Instructor
1999-2002 1999-2002 京都大学大学院生命科学研究科 1999-2002 Graduate School of Bio studies, Kyoto University. Instructor 助手 Instructor
2002-2015/11/30 2002- 京都大学大学院生命科学研究科 2002- Graduate School of Biostudies, Kyoto University 講師 Lecturer
2015/12/01- 京都大学大学院生命科学研究科 Graduate School of Biostudies, Kyoto University 准教授 Associate Professor
Language of Instruction
Language(japanese) Language(english) Code
英語 English eng
ORCID ID
https://orcid.org/0000-0003-4730-8187
researchmap URL
https://researchmap.jp/read0057493
Research Topics
(Japanese)
高次生命体の非自己認識機構を分子・細胞・個体レベルで解析し誘導される応答の制御機構を明らかにする。さらに、それを基にして新たな免疫制御法の開発を目指す。
(English)
Development of new methods to control immune reactions though understanding immune system.
Overview of the research
(Japanese)
1. ヒトV型コラーゲン遺伝子のクローニングとEhlers-Danlos症候群における変異の同定  V型コラーゲンは他の繊維状コラーゲンの径・強度を制御すると考えられていた。そこで、当該cDNAをクローニングし、さらに遺伝子(Exon-Intron)構造を明らかにした。その結果、V型コラーゲンにはN末端非コラーゲン領域が存在し、これが繊維の径・強度に影響を与えるものと考えられた。さらに、皮膚、関節、血管等の脆弱性を示すEhlers-Danlos症候群の患者で、V型コラーゲン遺伝子の転座およびN末端非コラーゲン領域にてExon skipが生じる変異を同定した。 2. コラーゲンの不溶化に働く酵素の同定  コラーゲン前駆体は可溶性で、細胞外でC末端非コラーゲン領域が切断され不溶化する。しかし、その切断部位は非特異的分解を受けやすく、切断酵素の同定が困難であった。そこで始めに、当該切断活性を促進する因子PCOLCEをクローニングした。PCOLCEは蛋白間結合に働くCUBドメイン有していた。そこで、同ドメインを有するハエ胚背腹軸形成因子BMP-1を上記切断酵素であると予想し、これを証明した。以上の研究より、長年課題であったコラーゲンの不溶化機構を明らかにした。 3. 免疫系細胞に発現するレクチンの同定と糖鎖認識に関する研究  樹状細胞 (dendritic cell, DC)やマクロファージ(macrophage, Mf)は、多様なpattern recognition receptor(PRR)により病原体を認識する。このPRRの一つであるレクチンの機能を解析するために、マウスDC/Mfに発現するランゲリンおよび5個のSIGNRファミリー遺伝子を新規に同定し機能を解析した。続いて、その中のSIGNR1がサルモネラやキャンディダ等を認識し、サイトカイン産生を昂進する事を示した。また、それら病原体表面のSIGNR1認識糖鎖構造を明らかにした。 4. 病原体認識における異なるPRRの共同作用に関する研究  実際の免疫細胞による病原体認識は、多様なPRRにより同時に起こる。そこで、SIGNR1を中心に他のPRRとの共同作用を検討した。その結果、SIGNR1が同じくレクチンであるDectin-1や、タイプの異なるtoll-like receptor (TLR)2および4と物理的に会合し、殺菌性酸素種および炎症性サイトカインの産生を昂進する事を見出した。 5. レクチンを介した免疫抑制機構に関する研究  C. albicans表面の可溶性糖蛋白はヒトを免疫抑制状態に導く。そこでヒトレクチンDC-SIGNの同機構への関与を検討した。先ず、糖鎖アレイ解析でDC-SIGNは病原性C. albicans N-glycanには結合するが、非病原性のS. cerevisiae のそれには結合しないことを示した。また、DC-SIGN発現RAW264.7細胞株は、S. cerevisiaeよりもC. albicansのN-glycanに対して多くの免疫抑制性サイトカインIL-10を産生した。よって、C. albicansは当該N-glycanおよび宿主DC-SIGNを介して免疫応答を抑制すると思われる。 6. 微細粒子に対するサイズ依存的な細胞応答経路の解析  シリカやアスベスト等の微細粒子はDC/MfからのIL-1bの産生を誘導する。しかし、これ迄は被検粒子が様々サイズの混合物であった為、粒子のサイズに依存する細胞応答が存在するかは不明であった。そこで、骨髄由来Mfを様々な大きさのラッテクスビーズ(LxB)で刺激したところ、1,000および20 nm径LxBはIL-1bの産生を誘導するが、100 nm径LxBはしないことを見出した。さらに1,000 nm径LxBはミトコンドリアからの活性酸素種依存的、20 nm径LxBは食胞からのcathepsin Bの漏出依存的に、独立してIL-1b産生に働くことが示された。これらの結果は、粒子サイズ依存的な応答経路の存在を示し、また、微細粒子の生体毒性機構の解明と新たな治療法の開発に寄与するものと考える。
(English)
Our interest is the induction and control of immunity. We focus on dendritic cells (DC), which are a primary antigen-presenting cell in the immune system. We are especially interested in functions of lectin molecules expressed on DC and its relative, macrophage, that recognize polysaccharides on pathogenic agents. The study includes analyses of interaction between polysaccharides and lectins, and subsequent cellular and systemic responses in co-operation with TLR signaling. In this study, we found that certain lectin-polysaccharide interaction induced immune suppressive environment, ameliorating excessive and lethal inflammation. By these studies, we would like to develop new methods to control immune system.
Fields of research (key words)
Key words(Japanese) Key words(English)
免疫学 Immunology
レクチン Lectin
樹状細胞 Dendritic Cells
マクロファージ Macrophage
Published Papers
Author Author(Japanese) Author(English) Title Title(Japanese) Title(English) Bibliography Bibliography(Japanese) Bibliography(English) Publication date Refereed paper Language Publishing type Disclose
Guangwei Cui, Akihiro Shimba, Guangyong Ma, Kazuhiko Takahara, Shizue Tani-Ichi, Yuanbo Zhu, Takuma Asahi, Akifumi Abe, Hitoshi Miyachi, Satsuki Kitano, Takahiro Hara, Jun-Ichirou Yasunaga, Hirotsugu Suwanai, Hisakata Yamada, Masao Matsuoka, Kohjiro Ueki, Yasunobu Yoshikai, Koichi Ikuta Guangwei Cui, Akihiro Shimba, Guangyong Ma, Kazuhiko Takahara, Shizue Tani-Ichi, Yuanbo Zhu, Takuma Asahi, Akifumi Abe, Hitoshi Miyachi, Satsuki Kitano, Takahiro Hara, Jun-Ichirou Yasunaga, Hirotsugu Suwanai, Hisakata Yamada, Masao Matsuoka, Kohjiro Ueki, Yasunobu Yoshikai, Koichi Ikuta Guangwei Cui, Akihiro Shimba, Guangyong Ma, Kazuhiko Takahara, Shizue Tani-Ichi, Yuanbo Zhu, Takuma Asahi, Akifumi Abe, Hitoshi Miyachi, Satsuki Kitano, Takahiro Hara, Jun-Ichirou Yasunaga, Hirotsugu Suwanai, Hisakata Yamada, Masao Matsuoka, Kohjiro Ueki, Yasunobu Yoshikai, Koichi Ikuta IL-7R-Dependent Phosphatidylinositol 3-Kinase Competes with the STAT5 Signal to Modulate T Cell Development and Homeostasis. IL-7R-Dependent Phosphatidylinositol 3-Kinase Competes with the STAT5 Signal to Modulate T Cell Development and Homeostasis. IL-7R-Dependent Phosphatidylinositol 3-Kinase Competes with the STAT5 Signal to Modulate T Cell Development and Homeostasis. Journal of immunology (Baltimore, Md. : 1950), 204, 4, 844-857 Journal of immunology (Baltimore, Md. : 1950), 204, 4, 844-857 Journal of immunology (Baltimore, Md. : 1950), 204, 4, 844-857 2020/02/15 Refereed English Research paper(scientific journal) Disclose to all
Takeo Goji, Kazuhiko Takahara, Manabu Negishi, Hironori Katoh Takeo Goji, Kazuhiko Takahara, Manabu Negishi, Hironori Katoh Takeo Goji, Kazuhiko Takahara, Manabu Negishi, Hironori Katoh Cystine uptake through the cystine/glutamate antiporter xCT triggers glioblastoma cell death under glucose deprivation Cystine uptake through the cystine/glutamate antiporter xCT triggers glioblastoma cell death under glucose deprivation Cystine uptake through the cystine/glutamate antiporter xCT triggers glioblastoma cell death under glucose deprivation JOURNAL OF BIOLOGICAL CHEMISTRY, 292, 48, 19721-19732 JOURNAL OF BIOLOGICAL CHEMISTRY, 292, 48, 19721-19732 JOURNAL OF BIOLOGICAL CHEMISTRY, 292, 48, 19721-19732 2017/12 Refereed English Research paper(scientific journal) Disclose to all
Toshifumi Ishiguro, Tetsuya Fukawa, Kotaro Akaki, Koji Nagaoka, Tatsuki Takeda, Yoichiro Iwakura, Kayo Inaba, Kazuhiko Takahara Toshifumi Ishiguro, Tetsuya Fukawa, Kotaro Akaki, Koji Nagaoka, Tatsuki Takeda, Yoichiro Iwakura, Kayo Inaba, Kazuhiko Takahara Toshifumi Ishiguro, Tetsuya Fukawa, Kotaro Akaki, Koji Nagaoka, Tatsuki Takeda, Yoichiro Iwakura, Kayo Inaba, Kazuhiko Takahara Absence of DCIR1 reduces the mortality rate of endotoxemic hepatitis in mice Absence of DCIR1 reduces the mortality rate of endotoxemic hepatitis in mice Absence of DCIR1 reduces the mortality rate of endotoxemic hepatitis in mice EUROPEAN JOURNAL OF IMMUNOLOGY, 47, 4, 704-712 EUROPEAN JOURNAL OF IMMUNOLOGY, 47, 4, 704-712 EUROPEAN JOURNAL OF IMMUNOLOGY, 47, 4, 704-712 2017/04 Refereed English Research paper(scientific journal) Disclose to all
Maki Ushida, Tomonori Iyoda, Mitsuhiro Kanamori, Hiroshi Watarai, Kazuhiko Takahara, Kayo Inaba M. Ushida, T. Iyoda, M. Kanamori, H. Watarai, K. Takahara, K. Inaba Maki Ushida, Tomonori Iyoda, Mitsuhiro Kanamori, Hiroshi Watarai, Kazuhiko Takahara, Kayo Inaba In vivo and in vitro analyses of alpha-galactosylceramide uptake by conventional dendritic cell subsets using its fluorescence-labeled derivative In vivo and in vitro analyses of α-galactosylceramide uptake by conventional dendritic cell subsets using its fluorescence-labeled derivative In vivo and in vitro analyses of alpha-galactosylceramide uptake by conventional dendritic cell subsets using its fluorescence-labeled derivative IMMUNOLOGY LETTERS, 168, 2, 300-305 Immunology Letters, 168, 2, 300-305 IMMUNOLOGY LETTERS, 168, 2, 300-305 2015/12 Refereed English Research paper(scientific journal) Disclose to all
Sumika Tokieda, Marie Komori, Toshifumi Ishiguro, Yoichiro Iwakura, Kazuhiko Takahara, Kayo Inaba Sumika Tokieda, Marie Komori, Toshifumi Ishiguro, Yoichiro Iwakura, Kazuhiko Takahara, Kayo Inaba Sumika Tokieda, Marie Komori, Toshifumi Ishiguro, Yoichiro Iwakura, Kazuhiko Takahara, Kayo Inaba Dendritic cell immunoreceptor 1 alters neutrophil responses in the development of experimental colitis Dendritic cell immunoreceptor 1 alters neutrophil responses in the development of experimental colitis Dendritic cell immunoreceptor 1 alters neutrophil responses in the development of experimental colitis BMC IMMUNOLOGY, 16 BMC IMMUNOLOGY, 16 BMC IMMUNOLOGY, 16 2015/10 Refereed English Research paper(scientific journal) Disclose to all
Jun Taneo, Takumi Adachi, Aiko Yoshida, Kunio Takayasu, Kazuhiko Takahara, Kayo Inaba J. Taneo, T. Adachi, A. Yoshida, K. Takayasu, K. Takahara, K. Inaba Jun Taneo, Takumi Adachi, Aiko Yoshida, Kunio Takayasu, Kazuhiko Takahara, Kayo Inaba Amyloid beta oligomers induce interleukin-1 beta production in primary microglia in a cathepsin B- and reactive oxygen species-dependent manner Amyloid β oligomers induce interleukin-1β production in primary microglia in a cathepsin B- and reactive oxygen species-dependent manner Amyloid beta oligomers induce interleukin-1 beta production in primary microglia in a cathepsin B- and reactive oxygen species-dependent manner BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 458, 3, 561-567 Biochemical and Biophysical Research Communications, 458, 3, 561-567 BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 458, 3, 561-567 2015/03 Refereed English Research paper(scientific journal) Disclose to all
Takumi Adachi, Kazuhiko Takahara, Jun Taneo, Yasuo Uchiyama, Kayo Inaba Takumi Adachi, Kazuhiko Takahara, Jun Taneo, Yasuo Uchiyama, Kayo Inaba Takumi Adachi, Kazuhiko Takahara, Jun Taneo, Yasuo Uchiyama, Kayo Inaba Particle Size of Latex Beads Dictates IL-1 beta Production Mechanism Particle Size of Latex Beads Dictates IL-1 beta Production Mechanism Particle Size of Latex Beads Dictates IL-1 beta Production Mechanism PLOS ONE, 8, 7, e68499 PLOS ONE, 8, 7, e68499 PLOS ONE, 8, 7, e68499 2013/07 Refereed English Research paper(scientific journal) Disclose to all
Kento Minamino, Kazuhiko Takahara, Takumi Adachi, Koji Nagaoka, Tomonori Iyoda, Shinsuke Taki, Kayo Inaba Kento Minamino, Kazuhiko Takahara, Takumi Adachi, Koji Nagaoka, Tomonori Iyoda, Shinsuke Taki, Kayo Inaba Kento Minamino, Kazuhiko Takahara, Takumi Adachi, Koji Nagaoka, Tomonori Iyoda, Shinsuke Taki, Kayo Inaba IRF-2 regulates B-cell proliferation and antibody production through distinct mechanisms IRF-2 regulates B-cell proliferation and antibody production through distinct mechanisms IRF-2 regulates B-cell proliferation and antibody production through distinct mechanisms INTERNATIONAL IMMUNOLOGY, 24, 9, 573-581 INTERNATIONAL IMMUNOLOGY, 24, 9, 573-581 INTERNATIONAL IMMUNOLOGY, 24, 9, 573-581 2012/09 Refereed English Research paper(scientific journal) Disclose to all
Kazuhiko Takahara, Takuya Arita, Sumika Tokieda, Nobuyuki Shibata, Yoshio Okawa, Hiroaki Tateno, Jun Hirabayashi, Kayo Inaba Kazuhiko Takahara, Takuya Arita, Sumika Tokieda, Nobuyuki Shibata, Yoshio Okawa, Hiroaki Tateno, Jun Hirabayashi, Kayo Inaba Kazuhiko Takahara, Takuya Arita, Sumika Tokieda, Nobuyuki Shibata, Yoshio Okawa, Hiroaki Tateno, Jun Hirabayashi, Kayo Inaba Difference in Fine Specificity to Polysaccharides of Candida albicans Mannoprotein between Mouse SIGNR1 and Human DC-SIGN Difference in Fine Specificity to Polysaccharides of Candida albicans Mannoprotein between Mouse SIGNR1 and Human DC-SIGN Difference in Fine Specificity to Polysaccharides of Candida albicans Mannoprotein between Mouse SIGNR1 and Human DC-SIGN INFECTION AND IMMUNITY, 80, 5, 1699-1706 INFECTION AND IMMUNITY, 80, 5, 1699-1706 INFECTION AND IMMUNITY, 80, 5, 1699-1706 2012/05 Refereed English Research paper(scientific journal) Disclose to all
Kazuhiko Takahara, Sumika Tokieda, Koji Nagaoka, Kayo Inaba Kazuhiko Takahara, Sumika Tokieda, Koji Nagaoka, Kayo Inaba Efficient capture of Candida albicans and zymosan by SIGNR1 augments TLR2-dependent TNF-alpha production Efficient capture of Candida albicans and zymosan by SIGNR1 augments TLR2-dependent TNF-α production[要修正] Efficient capture of Candida albicans and zymosan by SIGNR1 augments TLR2-dependent TNF-alpha production INTERNATIONAL IMMUNOLOGY, 24, 2, 89-+ , 24, 2, 89-+ INTERNATIONAL IMMUNOLOGY, 24, 2, 89-+ 2012/02 Refereed English Research paper(scientific journal) Disclose to all
Chisa Kobayashi, Takashi Shiina, Atsuko Tokioka, Yuki Hattori, Takaya Komori, Mikiko Kobayashi-Miura, Toshihiro Takizawa, Kazuhiko Takahara, Kayo Inaba, Hidetoshi Inoko, Motohiro Takeya, Glenn Dranoff, Masahiko Sugita Chisa Kobayashi, Takashi Shiina, Atsuko Tokioka, Yuki Hattori, Takaya Komori, Mikiko Kobayashi-Miura, Toshihiro Takizawa, Kazuhiko Takahara, Kayo Inaba, Hidetoshi Inoko, Motohiro Takeya, Glenn Dranoff, Masahiko Sugita Chisa Kobayashi, Takashi Shiina, Atsuko Tokioka, Yuki Hattori, Takaya Komori, Mikiko Kobayashi-Miura, Toshihiro Takizawa, Kazuhiko Takahara, Kayo Inaba, Hidetoshi Inoko, Motohiro Takeya, Glenn Dranoff, Masahiko Sugita GM-CSF-Independent CD1a Expression in Epidermal Langerhans Cells: Evidence from Human CD1A Genome-Transgenic Mice GM-CSF-Independent CD1a Expression in Epidermal Langerhans Cells: Evidence from Human CD1A Genome-Transgenic Mice GM-CSF-Independent CD1a Expression in Epidermal Langerhans Cells: Evidence from Human CD1A Genome-Transgenic Mice JOURNAL OF INVESTIGATIVE DERMATOLOGY, 132, 1, 241-244 JOURNAL OF INVESTIGATIVE DERMATOLOGY, 132, 1, 241-244 JOURNAL OF INVESTIGATIVE DERMATOLOGY, 132, 1, 241-244 2012/01 Refereed English Disclose to all
Kazuhiko Takahara, Sumika Tokieda, Koji Nagaoka, Tatsuki Takeda, Yukino Kimura, Kayo Inaba Kazuhiko Takahara, Sumika Tokieda, Koji Nagaoka, Tatsuki Takeda, Yukino Kimura, Kayo Inaba Kazuhiko Takahara, Sumika Tokieda, Koji Nagaoka, Tatsuki Takeda, Yukino Kimura, Kayo Inaba C-type lectin SIGNR1 enhances cellular oxidative burst response against C. albicans in cooperation with Dectin-1 C-type lectin SIGNR1 enhances cellular oxidative burst response against C. albicans in cooperation with Dectin-1 C-type lectin SIGNR1 enhances cellular oxidative burst response against C. albicans in cooperation with Dectin-1 EUROPEAN JOURNAL OF IMMUNOLOGY, 41, 5, 1435-1444 EUROPEAN JOURNAL OF IMMUNOLOGY, 41, 5, 1435-1444 EUROPEAN JOURNAL OF IMMUNOLOGY, 41, 5, 1435-1444 2011/05 Refereed English Research paper(scientific journal) Disclose to all
Koji Nagaoka, Kazuhiko Takahara, Kento Minamino, Tatsuki Takeda, Yoko Yoshida, Kayo Inaba Koji Nagaoka, Kazuhiko Takahara, Kento Minamino, Tatsuki Takeda, Yoko Yoshida, Kayo Inaba Koji Nagaoka, Kazuhiko Takahara, Kento Minamino, Tatsuki Takeda, Yoko Yoshida, Kayo Inaba Expression of C-type lectin, SIGNR3, on subsets of dendritic cells, macrophages, and monocytes Expression of C-type lectin, SIGNR3, on subsets of dendritic cells, macrophages, and monocytes Expression of C-type lectin, SIGNR3, on subsets of dendritic cells, macrophages, and monocytes JOURNAL OF LEUKOCYTE BIOLOGY, 88, 5, 913-924 JOURNAL OF LEUKOCYTE BIOLOGY, 88, 5, 913-924 JOURNAL OF LEUKOCYTE BIOLOGY, 88, 5, 913-924 2010/11 Refereed English Research paper(scientific journal) Disclose to all
Dong-Min Shin, Chul-Su Yang, Jae-Min Yuk, Ji-Yeon Lee, Ki Hye Kim, Sung Jae Shin, Kazuhiko Takahara, Sung Joong Lee, Eun-Kyeong Jo Dong-Min Shin, Chul-Su Yang, Jae-Min Yuk, Ji-Yeon Lee, Ki Hye Kim, Sung Jae Shin, Kazuhiko Takahara, Sung Joong Lee, Eun-Kyeong Jo Dong-Min Shin, Chul-Su Yang, Jae-Min Yuk, Ji-Yeon Lee, Ki Hye Kim, Sung Jae Shin, Kazuhiko Takahara, Sung Joong Lee, Eun-Kyeong Jo Mycobacterium abscessus activates the macrophage innate immune response via a physical and functional interaction between TLR2 and dectin-1 Mycobacterium abscessus activates the macrophage innate immune response via a physical and functional interaction between TLR2 and dectin-1 Mycobacterium abscessus activates the macrophage innate immune response via a physical and functional interaction between TLR2 and dectin-1 CELLULAR MICROBIOLOGY, 10, 8, 1608-1621 CELLULAR MICROBIOLOGY, 10, 8, 1608-1621 CELLULAR MICROBIOLOGY, 10, 8, 1608-1621 2008/08 Refereed English Research paper(scientific journal) Disclose to all
K Nagaoka, K Takahara, H Yoshida, RM Steinman, S Saitoh, S Akashi-Takamura, K Miyake, YS Kang, CG Park, K Inaba K Nagaoka, K Takahara, H Yoshida, RM Steinman, S Saitoh, S Akashi-Takamura, K Miyake, YS Kang, CG Park, K Inaba K Nagaoka, K Takahara, H Yoshida, RM Steinman, S Saitoh, S Akashi-Takamura, K Miyake, YS Kang, CG Park, K Inaba Association of SIGNR1 with TLR4-MD-2 enhances signal transduction by recognition of LPS in gram-negative bacteria Association of SIGNR1 with TLR4-MD-2 enhances signal transduction by recognition of LPS in gram-negative bacteria Association of SIGNR1 with TLR4-MD-2 enhances signal transduction by recognition of LPS in gram-negative bacteria INTERNATIONAL IMMUNOLOGY, 17, 7, 827-836 INTERNATIONAL IMMUNOLOGY, 17, 7, 827-836 INTERNATIONAL IMMUNOLOGY, 17, 7, 827-836 2005/07 Refereed English Research paper(scientific journal) Disclose to all
K Takahara, Y Yashima, Y Omatsu, H Yoshida, Y Kimura, YS Kang, RM Steinman, CG Park, K Inaba K Takahara, Y Yashima, Y Omatsu, H Yoshida, Y Kimura, YS Kang, RM Steinman, CG Park, K Inaba K Takahara, Y Yashima, Y Omatsu, H Yoshida, Y Kimura, YS Kang, RM Steinman, CG Park, K Inaba Functional comparison of the mouse DC-SIGN, SIGNR1, SIGNR3 and Langerin, C-type lectins Functional comparison of the mouse DC-SIGN, SIGNR1, SIGNR3 and Langerin, C-type lectins Functional comparison of the mouse DC-SIGN, SIGNR1, SIGNR3 and Langerin, C-type lectins INTERNATIONAL IMMUNOLOGY, 16, 6, 819-829 INTERNATIONAL IMMUNOLOGY, 16, 6, 819-829 INTERNATIONAL IMMUNOLOGY, 16, 6, 819-829 2004/06 Refereed English Research paper(scientific journal) Disclose to all
E Ichikawa, S Hida, Y Omatsu, S Shimoyama, K Takahara, S Miyagawa, K Inaba, S Taki E Ichikawa, S Hida, Y Omatsu, S Shimoyama, K Takahara, S Miyagawa, K Inaba, S Taki E Ichikawa, S Hida, Y Omatsu, S Shimoyama, K Takahara, S Miyagawa, K Inaba, S Taki Defective development of splenic and epidermal CD4(+) dendritic cells in mice deficient for IFN regulatory factor-2 Defective development of splenic and epidermal CD4(+) dendritic cells in mice deficient for IFN regulatory factor-2 Defective development of splenic and epidermal CD4(+) dendritic cells in mice deficient for IFN regulatory factor-2 PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 101, 11, 3909-3914 PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 101, 11, 3909-3914 PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 101, 11, 3909-3914 2004/03 Refereed English Research paper(scientific journal) Disclose to all
WM Wang, S Lee, BM Steiglitz, IC Scott, CC Lebares, ML Allen, MC Brenner, K Takahara, DS Greenspan WM Wang, S Lee, BM Steiglitz, IC Scott, CC Lebares, ML Allen, MC Brenner, K Takahara, DS Greenspan WM Wang, S Lee, BM Steiglitz, IC Scott, CC Lebares, ML Allen, MC Brenner, K Takahara, DS Greenspan Transforming growth factor-beta induces secretion of activated ADAMTS-2 - A procollagen IIIN-proteinase Transforming growth factor-beta induces secretion of activated ADAMTS-2 - A procollagen IIIN-proteinase Transforming growth factor-beta induces secretion of activated ADAMTS-2 - A procollagen IIIN-proteinase JOURNAL OF BIOLOGICAL CHEMISTRY, 278, 21, 19549-19557 JOURNAL OF BIOLOGICAL CHEMISTRY, 278, 21, 19549-19557 JOURNAL OF BIOLOGICAL CHEMISTRY, 278, 21, 19549-19557 2003/05 Refereed English Research paper(scientific journal) Disclose to all
YS Kang, S Yamazaki, T Iyoda, M Pack, SA Bruening, JY Kim, K Takahara, K Inaba, RM Steinman, CG Park YS Kang, S Yamazaki, T Iyoda, M Pack, SA Bruening, JY Kim, K Takahara, K Inaba, RM Steinman, CG Park YS Kang, S Yamazaki, T Iyoda, M Pack, SA Bruening, JY Kim, K Takahara, K Inaba, RM Steinman, CG Park SIGN-R1, a novel C-type lectin expressed by marginal zone macrophages in spleen, mediates uptake of the polysaccharide dextran SIGN-R1, a novel C-type lectin expressed by marginal zone macrophages in spleen, mediates uptake of the polysaccharide dextran SIGN-R1, a novel C-type lectin expressed by marginal zone macrophages in spleen, mediates uptake of the polysaccharide dextran INTERNATIONAL IMMUNOLOGY, 15, 2, 177-186 INTERNATIONAL IMMUNOLOGY, 15, 2, 177-186 INTERNATIONAL IMMUNOLOGY, 15, 2, 177-186 2003/02 Refereed English Research paper(scientific journal) Disclose to all
AH Ligon, IC Scott, K Takahara, DS Greenspan, CC Morton AH Ligon, IC Scott, K Takahara, DS Greenspan, CC Morton AH Ligon, IC Scott, K Takahara, DS Greenspan, CC Morton PCOLCE deletion and expression analyses in uterine leiomyomata PCOLCE deletion and expression analyses in uterine leiomyomata PCOLCE deletion and expression analyses in uterine leiomyomata CANCER GENETICS AND CYTOGENETICS, 137, 2, 133-137 CANCER GENETICS AND CYTOGENETICS, 137, 2, 133-137 CANCER GENETICS AND CYTOGENETICS, 137, 2, 133-137 2002/09 Refereed English Research paper(scientific journal) Disclose to all
K Takahara, U Schwarze, Y Imamura, GG Hoffman, H Toriello, LT Smith, PH Byers, DS Greenspan K Takahara, U Schwarze, Y Imamura, GG Hoffman, H Toriello, LT Smith, PH Byers, DS Greenspan K Takahara, U Schwarze, Y Imamura, GG Hoffman, H Toriello, LT Smith, PH Byers, DS Greenspan Order of intron removal influences multiple splice outcomes, including a two-exon skip, in a COL5A1 acceptor-site mutation that results in abnormal pro-alpha 1(V) N-propeptides and Ehlers-Danlos syndrome type I Order of intron removal influences multiple splice outcomes, including a two-exon skip, in a COL5A1 acceptor-site mutation that results in abnormal pro-alpha 1(V) N-propeptides and Ehlers-Danlos syndrome type I Order of intron removal influences multiple splice outcomes, including a two-exon skip, in a COL5A1 acceptor-site mutation that results in abnormal pro-alpha 1(V) N-propeptides and Ehlers-Danlos syndrome type I AMERICAN JOURNAL OF HUMAN GENETICS, 71, 3, 451-465 AMERICAN JOURNAL OF HUMAN GENETICS, 71, 3, 451-465 AMERICAN JOURNAL OF HUMAN GENETICS, 71, 3, 451-465 2002/09 Refereed English Research paper(scientific journal) Disclose to all
T Iyoda, S Shimoyama, K Liu, Y Omatsu, Y Akiyama, Y Maeda, K Takahara, RM Steinman, K Inaba T Iyoda, S Shimoyama, K Liu, Y Omatsu, Y Akiyama, Y Maeda, K Takahara, RM Steinman, K Inaba T Iyoda, S Shimoyama, K Liu, Y Omatsu, Y Akiyama, Y Maeda, K Takahara, RM Steinman, K Inaba The CD8(+) dendritic cell subset selectively endocytoses dying cells in culture and in vivo The CD8(+) dendritic cell subset selectively endocytoses dying cells in culture and in vivo The CD8(+) dendritic cell subset selectively endocytoses dying cells in culture and in vivo JOURNAL OF EXPERIMENTAL MEDICINE, 195, 10, 1289-1302 JOURNAL OF EXPERIMENTAL MEDICINE, 195, 10, 1289-1302 JOURNAL OF EXPERIMENTAL MEDICINE, 195, 10, 1289-1302 2002/05 Refereed English Research paper(scientific journal) Disclose to all
K Takahara, Y Omatsu, Y Yashima, Y Maeda, S Tanaka, T Iyoda, BE Clausen, K Matsubara, J Letterio, RM Steinman, Y Matsuda, K Inaba K Takahara, Y Omatsu, Y Yashima, Y Maeda, S Tanaka, T Iyoda, BE Clausen, K Matsubara, J Letterio, RM Steinman, Y Matsuda, K Inaba K Takahara, Y Omatsu, Y Yashima, Y Maeda, S Tanaka, T Iyoda, BE Clausen, K Matsubara, J Letterio, RM Steinman, Y Matsuda, K Inaba Identification and expression of mouse Langerin (CD207) in dendritic cells Identification and expression of mouse Langerin (CD207) in dendritic cells Identification and expression of mouse Langerin (CD207) in dendritic cells INTERNATIONAL IMMUNOLOGY, 14, 5, 433-444 INTERNATIONAL IMMUNOLOGY, 14, 5, 433-444 INTERNATIONAL IMMUNOLOGY, 14, 5, 433-444 2002/05 Refereed English Research paper(scientific journal) Disclose to all
N Ichioka, M Inaba, T Kushida, T Esumi, K Takahara, K Inaba, R Ogawa, H Iida, S Ikehara N Ichioka, M Inaba, T Kushida, T Esumi, K Takahara, K Inaba, R Ogawa, H Iida, S Ikehara N Ichioka, M Inaba, T Kushida, T Esumi, K Takahara, K Inaba, R Ogawa, H Iida, S Ikehara Prevention of senile osteoporosis in SAMP6 mice by intrabone marrow injection of allogeneic bone marrow cells Prevention of senile osteoporosis in SAMP6 mice by intrabone marrow injection of allogeneic bone marrow cells Prevention of senile osteoporosis in SAMP6 mice by intrabone marrow injection of allogeneic bone marrow cells STEM CELLS, 20, 6, 542-551 STEM CELLS, 20, 6, 542-551 STEM CELLS, 20, 6, 542-551 2002 Refereed English Research paper(scientific journal) Disclose to all
CG Park, K Takahara, E Umemoto, Y Yashima, K Matsubara, Y Matsuda, BE Clausen, K Inaba, RM Steinman CG Park, K Takahara, E Umemoto, Y Yashima, K Matsubara, Y Matsuda, BE Clausen, K Inaba, RM Steinman CG Park, K Takahara, E Umemoto, Y Yashima, K Matsubara, Y Matsuda, BE Clausen, K Inaba, RM Steinman Five mouse homologues of the human dendritic cell C-type lectin, DC-SIGN Five mouse homologues of the human dendritic cell C-type lectin, DC-SIGN Five mouse homologues of the human dendritic cell C-type lectin, DC-SIGN INTERNATIONAL IMMUNOLOGY, 13, 10, 1283-1290 INTERNATIONAL IMMUNOLOGY, 13, 10, 1283-1290 INTERNATIONAL IMMUNOLOGY, 13, 10, 1283-1290 2001/10 Refereed English Research paper(scientific journal) Disclose to all
Komuro, H Komuro, H Komuro, H Lack of BMP-1 gene mutations in patient with gastroschisis Lack of BMP-1 gene mutations in patient with gastroschisis Lack of BMP-1 gene mutations in patient with gastroschisis J. Pediatric Surgery 36, 885-887 J. Pediatric Surgery 36, 885-887 J. Pediatric Surgery 36, 885-887 2001 Refereed English Disclose to all
S Amano, IC Scott, K Takahara, M Koch, MF Champliaud, DR Gerecke, DR Keene, DL Hudson, T Nishiyama, S Lee, DS Greenspan, RE Burgeson S Amano, IC Scott, K Takahara, M Koch, MF Champliaud, DR Gerecke, DR Keene, DL Hudson, T Nishiyama, S Lee, DS Greenspan, RE Burgeson S Amano, IC Scott, K Takahara, M Koch, MF Champliaud, DR Gerecke, DR Keene, DL Hudson, T Nishiyama, S Lee, DS Greenspan, RE Burgeson Bone morphogenetic protein 1 is an extracellular processing enzyme of the laminin 5 gamma 2 chain Bone morphogenetic protein 1 is an extracellular processing enzyme of the laminin 5 gamma 2 chain Bone morphogenetic protein 1 is an extracellular processing enzyme of the laminin 5 gamma 2 chain JOURNAL OF BIOLOGICAL CHEMISTRY, 275, 30, 22728-22735 JOURNAL OF BIOLOGICAL CHEMISTRY, 275, 30, 22728-22735 JOURNAL OF BIOLOGICAL CHEMISTRY, 275, 30, 22728-22735 2000/07 Refereed English Research paper(scientific journal) Disclose to all
JD Mott, CL Thomas, MT Rosenbach, K Takahara, DS Greenspan, MJ Banda JD Mott, CL Thomas, MT Rosenbach, K Takahara, DS Greenspan, MJ Banda JD Mott, CL Thomas, MT Rosenbach, K Takahara, DS Greenspan, MJ Banda Post-translational proteolytic processing of procollagen C-terminal proteinase enhancer releases a metalloproteinase inhibitor Post-translational proteolytic processing of procollagen C-terminal proteinase enhancer releases a metalloproteinase inhibitor Post-translational proteolytic processing of procollagen C-terminal proteinase enhancer releases a metalloproteinase inhibitor JOURNAL OF BIOLOGICAL CHEMISTRY, 275, 2, 1384-1390 JOURNAL OF BIOLOGICAL CHEMISTRY, 275, 2, 1384-1390 JOURNAL OF BIOLOGICAL CHEMISTRY, 275, 2, 1384-1390 2000/01 Refereed English Research paper(scientific journal) Disclose to all
IC Scott, IL Blitz, WN Pappano, Y Imamura, TG Clark, BM Steiglitz, CL Thomas, SA Maas, K Takahara, KWY Cho, DS Greenspan IC Scott, IL Blitz, WN Pappano, Y Imamura, TG Clark, BM Steiglitz, CL Thomas, SA Maas, K Takahara, KWY Cho, DS Greenspan IC Scott, IL Blitz, WN Pappano, Y Imamura, TG Clark, BM Steiglitz, CL Thomas, SA Maas, K Takahara, KWY Cho, DS Greenspan Mammalian BMP-1/tolloid-related metalloproteinases, including novel family member mammalian tolloid-like 2, have differential enzymatic activities and distributions of expression relevant to patterning and skeletogenesis Mammalian BMP-1/tolloid-related metalloproteinases, including novel family member mammalian tolloid-like 2, have differential enzymatic activities and distributions of expression relevant to patterning and skeletogenesis Mammalian BMP-1/tolloid-related metalloproteinases, including novel family member mammalian tolloid-like 2, have differential enzymatic activities and distributions of expression relevant to patterning and skeletogenesis DEVELOPMENTAL BIOLOGY, 213, 2, 283-300 DEVELOPMENTAL BIOLOGY, 213, 2, 283-300 DEVELOPMENTAL BIOLOGY, 213, 2, 283-300 1999/09 Refereed English Research paper(scientific journal) Disclose to all
IC Scott, TG Clark, K Takahara, GG Hoffman, DS Greenspan IC Scott, TG Clark, K Takahara, GG Hoffman, DS Greenspan IC Scott, TG Clark, K Takahara, GG Hoffman, DS Greenspan Structural organization and expression patterns of the human and mouse genes for the type I procollagen COOH-terminal proteinase enhancer protein Structural organization and expression patterns of the human and mouse genes for the type I procollagen COOH-terminal proteinase enhancer protein Structural organization and expression patterns of the human and mouse genes for the type I procollagen COOH-terminal proteinase enhancer protein GENOMICS, 55, 2, 229-234 GENOMICS, 55, 2, 229-234 GENOMICS, 55, 2, 229-234 1999/01 Refereed English Research paper(scientific journal) Disclose to all
IC Scott, TG Clark, K Takahara, GG Hoffman, RL Eddy, LL Haley, TB Shows, DS Greenspan IC Scott, TG Clark, K Takahara, GG Hoffman, RL Eddy, LL Haley, TB Shows, DS Greenspan IC Scott, TG Clark, K Takahara, GG Hoffman, RL Eddy, LL Haley, TB Shows, DS Greenspan Assignment of TLL1 and TLL2, which encode human BMP-1/Tolloid-related metalloproteases, to chromosomes 4q32 -> q33 and 10q23 -> q24 and assignment of murine Tll2 to chromosome 19 Assignment of TLL1 and TLL2, which encode human BMP-1/Tolloid-related metalloproteases, to chromosomes 4q32 -> q33 and 10q23 -> q24 and assignment of murine Tll2 to chromosome 19 Assignment of TLL1 and TLL2, which encode human BMP-1/Tolloid-related metalloproteases, to chromosomes 4q32 -> q33 and 10q23 -> q24 and assignment of murine Tll2 to chromosome 19 CYTOGENETICS AND CELL GENETICS, 86, 1, 64-65 CYTOGENETICS AND CELL GENETICS, 86, 1, 64-65 CYTOGENETICS AND CELL GENETICS, 86, 1, 64-65 1999 Refereed English Research paper(scientific journal) Disclose to all
SB Lee, DE SolowCordero, E Kessler, K Takahara, DS Greenspan SB Lee, DE SolowCordero, E Kessler, K Takahara, DS Greenspan SB Lee, DE SolowCordero, E Kessler, K Takahara, DS Greenspan Transforming growth factor-beta regulation of bone morphogenetic protein-1 procollagen C-proteinase and related proteins in fibrogenic cells and keratinocytes Transforming growth factor-beta regulation of bone morphogenetic protein-1 procollagen C-proteinase and related proteins in fibrogenic cells and keratinocytes Transforming growth factor-beta regulation of bone morphogenetic protein-1 procollagen C-proteinase and related proteins in fibrogenic cells and keratinocytes JOURNAL OF BIOLOGICAL CHEMISTRY, 272, 30, 19059-19066 JOURNAL OF BIOLOGICAL CHEMISTRY, 272, 30, 19059-19066 JOURNAL OF BIOLOGICAL CHEMISTRY, 272, 30, 19059-19066 1997/07 Refereed English Research paper(scientific journal) Disclose to all
N Suzuki, PA Labosky, Y Furuta, L Hargett, R Dunn, AB Fogo, K Takahara, DMP Peters, DS Greenspan, BLM Hogan N Suzuki, PA Labosky, Y Furuta, L Hargett, R Dunn, AB Fogo, K Takahara, DMP Peters, DS Greenspan, BLM Hogan N Suzuki, PA Labosky, Y Furuta, L Hargett, R Dunn, AB Fogo, K Takahara, DMP Peters, DS Greenspan, BLM Hogan Failure of ventral body wall closure in mouse embryos lacking a procollagen C-proteinase encoded by Bmp1, a mammalian gene related to Drosophila tolloid Failure of ventral body wall closure in mouse embryos lacking a procollagen C-proteinase encoded by Bmp1, a mammalian gene related to Drosophila tolloid Failure of ventral body wall closure in mouse embryos lacking a procollagen C-proteinase encoded by Bmp1, a mammalian gene related to Drosophila tolloid DEVELOPMENT, 122, 11, 3587-3595 DEVELOPMENT, 122, 11, 3587-3595 DEVELOPMENT, 122, 11, 3587-3595 1996/11 Refereed English Research paper(scientific journal) Disclose to all
HV Toriello, TW Glover, K Takahara, PH Byers, DE Miller, JV Higgins, DS Greenspan HV Toriello, TW Glover, K Takahara, PH Byers, DE Miller, JV Higgins, DS Greenspan HV Toriello, TW Glover, K Takahara, PH Byers, DE Miller, JV Higgins, DS Greenspan A translocation interrupts the COL5A1 gene in a patient with Ehlers-Danlos syndrome and hypomelanosis of Ito A translocation interrupts the COL5A1 gene in a patient with Ehlers-Danlos syndrome and hypomelanosis of Ito A translocation interrupts the COL5A1 gene in a patient with Ehlers-Danlos syndrome and hypomelanosis of Ito NATURE GENETICS, 13, 3, 361-365 NATURE GENETICS, 13, 3, 361-365 NATURE GENETICS, 13, 3, 361-365 1996/07 Refereed English Disclose to all
K Takahara, R Brevard, GG Hoffman, N Suzuki, DS Greenspan K Takahara, R Brevard, GG Hoffman, N Suzuki, DS Greenspan K Takahara, R Brevard, GG Hoffman, N Suzuki, DS Greenspan Characterization of a novel gene product (mammalian tolloid-like) with high sequence similarity to mammalian tolloid bone morphogenetic protein-1 Characterization of a novel gene product (mammalian tolloid-like) with high sequence similarity to mammalian tolloid bone morphogenetic protein-1 Characterization of a novel gene product (mammalian tolloid-like) with high sequence similarity to mammalian tolloid bone morphogenetic protein-1 GENOMICS, 34, 2, 157-165 GENOMICS, 34, 2, 157-165 GENOMICS, 34, 2, 157-165 1996/06 Refereed English Research paper(scientific journal) Disclose to all
E Kessler, K Takahara, L Biniaminov, M Brusel, DS Greenspan E Kessler, K Takahara, L Biniaminov, M Brusel, DS Greenspan E Kessler, K Takahara, L Biniaminov, M Brusel, DS Greenspan Bone morphogenetic protein-1: The type I procollagen C-proteinase Bone morphogenetic protein-1: The type I procollagen C-proteinase Bone morphogenetic protein-1: The type I procollagen C-proteinase SCIENCE, 271, 5247, 360-362 SCIENCE, 271, 5247, 360-362 SCIENCE, 271, 5247, 360-362 1996/01 Refereed English Research paper(scientific journal) Disclose to all
K Takahara, L Osborne, RW Elliott, LC Tsui, SW Scherer, DS Greenspan K Takahara, L Osborne, RW Elliott, LC Tsui, SW Scherer, DS Greenspan K Takahara, L Osborne, RW Elliott, LC Tsui, SW Scherer, DS Greenspan Fine mapping of the human and mouse genes for the type I procollagen COOH-terminal proteinase enhancer protein Fine mapping of the human and mouse genes for the type I procollagen COOH-terminal proteinase enhancer protein Fine mapping of the human and mouse genes for the type I procollagen COOH-terminal proteinase enhancer protein GENOMICS, 31, 2, 253-256 GENOMICS, 31, 2, 253-256 GENOMICS, 31, 2, 253-256 1996/01 Refereed English Research paper(scientific journal) Disclose to all
K Takahara, M Bong, R Brevard, RL Eddy, LL Haley, SJ Sait, TB Shows, GG Hoffman, DS Greenspan K Takahara, M Bong, R Brevard, RL Eddy, LL Haley, SJ Sait, TB Shows, GG Hoffman, DS Greenspan K Takahara, M Bong, R Brevard, RL Eddy, LL Haley, SJ Sait, TB Shows, GG Hoffman, DS Greenspan Mouse and human homologues of the yeast origin of replication recognition complex subunit ORC2 and chromosomal localization of the cognate human gene ORC2L Mouse and human homologues of the yeast origin of replication recognition complex subunit ORC2 and chromosomal localization of the cognate human gene ORC2L Mouse and human homologues of the yeast origin of replication recognition complex subunit ORC2 and chromosomal localization of the cognate human gene ORC2L GENOMICS, 31, 1, 119-122 GENOMICS, 31, 1, 119-122 GENOMICS, 31, 1, 119-122 1996/01 Refereed English Research paper(scientific journal) Disclose to all
K TAKAHARA, GG HOFFMAN, DS GREENSPAN K TAKAHARA, GG HOFFMAN, DS GREENSPAN K TAKAHARA, GG HOFFMAN, DS GREENSPAN COMPLETE STRUCTURAL ORGANIZATION OF THE HUMAN ALPHA-1(V) COLLAGEN GENE (COL5A1) - DIVERGENCE FROM THE CONSERVED ORGANIZATION OF OTHER CHARACTERIZED FIBRILLAR COLLAGEN GENES COMPLETE STRUCTURAL ORGANIZATION OF THE HUMAN ALPHA-1(V) COLLAGEN GENE (COL5A1) - DIVERGENCE FROM THE CONSERVED ORGANIZATION OF OTHER CHARACTERIZED FIBRILLAR COLLAGEN GENES COMPLETE STRUCTURAL ORGANIZATION OF THE HUMAN ALPHA-1(V) COLLAGEN GENE (COL5A1) - DIVERGENCE FROM THE CONSERVED ORGANIZATION OF OTHER CHARACTERIZED FIBRILLAR COLLAGEN GENES GENOMICS, 29, 3, 588-597 GENOMICS, 29, 3, 588-597 GENOMICS, 29, 3, 588-597 1995/10 Refereed English Research paper(scientific journal) Disclose to all
K TAKAHARA, S LEE, S WOOD, DS GREENSPAN K TAKAHARA, S LEE, S WOOD, DS GREENSPAN K TAKAHARA, S LEE, S WOOD, DS GREENSPAN STRUCTURAL ORGANIZATION AND GENETIC LOCALIZATION OF THE HUMAN BONE MORPHOGENETIC PROTEIN-1 MAMMALIAN TOLLOID GENE STRUCTURAL ORGANIZATION AND GENETIC LOCALIZATION OF THE HUMAN BONE MORPHOGENETIC PROTEIN-1 MAMMALIAN TOLLOID GENE STRUCTURAL ORGANIZATION AND GENETIC LOCALIZATION OF THE HUMAN BONE MORPHOGENETIC PROTEIN-1 MAMMALIAN TOLLOID GENE GENOMICS, 29, 1, 9-15 GENOMICS, 29, 1, 9-15 GENOMICS, 29, 1, 9-15 1995/09 Refereed English Research paper(scientific journal) Disclose to all
K TAKAHARA, GE LYONS, DS GREENSPAN K TAKAHARA, GE LYONS, DS GREENSPAN K TAKAHARA, GE LYONS, DS GREENSPAN BONE MORPHOGENETIC PROTEIN-1 AND A MAMMALIAN TOLLOID HOMOLOG (MTLD) ARE ENCODED BY ALTERNATIVELY SPLICED TRANSCRIPTS WHICH ARE DIFFERENTIALLY EXPRESSED IN SOME TISSUES BONE MORPHOGENETIC PROTEIN-1 AND A MAMMALIAN TOLLOID HOMOLOG (MTLD) ARE ENCODED BY ALTERNATIVELY SPLICED TRANSCRIPTS WHICH ARE DIFFERENTIALLY EXPRESSED IN SOME TISSUES BONE MORPHOGENETIC PROTEIN-1 AND A MAMMALIAN TOLLOID HOMOLOG (MTLD) ARE ENCODED BY ALTERNATIVELY SPLICED TRANSCRIPTS WHICH ARE DIFFERENTIALLY EXPRESSED IN SOME TISSUES JOURNAL OF BIOLOGICAL CHEMISTRY, 269, 51, 32572-32578 JOURNAL OF BIOLOGICAL CHEMISTRY, 269, 51, 32572-32578 JOURNAL OF BIOLOGICAL CHEMISTRY, 269, 51, 32572-32578 1994/12 Refereed English Research paper(scientific journal) Disclose to all
K TAKAHARA, E KESSLER, L BINIAMINOV, M BRUSEL, RL EDDY, S JANISAIT, TB SHOWS, DS GREENSPAN K TAKAHARA, E KESSLER, L BINIAMINOV, M BRUSEL, RL EDDY, S JANISAIT, TB SHOWS, DS GREENSPAN K TAKAHARA, E KESSLER, L BINIAMINOV, M BRUSEL, RL EDDY, S JANISAIT, TB SHOWS, DS GREENSPAN TYPE-I PROCOLLAGEN COOH-TERMINAL PROTEINASE ENHANCER PROTEIN - IDENTIFICATION, PRIMARY STRUCTURE, AND CHROMOSOMAL LOCALIZATION OF THE COGNATE HUMAN GENE (PCOLCE) TYPE-I PROCOLLAGEN COOH-TERMINAL PROTEINASE ENHANCER PROTEIN - IDENTIFICATION, PRIMARY STRUCTURE, AND CHROMOSOMAL LOCALIZATION OF THE COGNATE HUMAN GENE (PCOLCE) TYPE-I PROCOLLAGEN COOH-TERMINAL PROTEINASE ENHANCER PROTEIN - IDENTIFICATION, PRIMARY STRUCTURE, AND CHROMOSOMAL LOCALIZATION OF THE COGNATE HUMAN GENE (PCOLCE) JOURNAL OF BIOLOGICAL CHEMISTRY, 269, 42, 26280-26285 JOURNAL OF BIOLOGICAL CHEMISTRY, 269, 42, 26280-26285 JOURNAL OF BIOLOGICAL CHEMISTRY, 269, 42, 26280-26285 1994/10 Refereed English Research paper(scientific journal) Disclose to all
K TAKAHARA, N HAYASHI, K FUJITASAGAWA, T MORISHITA, Y HASHIMOTO, A NODA K TAKAHARA, N HAYASHI, K FUJITASAGAWA, T MORISHITA, Y HASHIMOTO, A NODA K TAKAHARA, N HAYASHI, K FUJITASAGAWA, T MORISHITA, Y HASHIMOTO, A NODA ALTERNATIVE SPLICING OF BOVINE TERMINAL DEOXYNUCLEOTIDYL TRANSFERASE CDNA ALTERNATIVE SPLICING OF BOVINE TERMINAL DEOXYNUCLEOTIDYL TRANSFERASE CDNA ALTERNATIVE SPLICING OF BOVINE TERMINAL DEOXYNUCLEOTIDYL TRANSFERASE CDNA BIOSCIENCE BIOTECHNOLOGY AND BIOCHEMISTRY, 58, 4, 786-787 BIOSCIENCE BIOTECHNOLOGY AND BIOCHEMISTRY, 58, 4, 786-787 BIOSCIENCE BIOTECHNOLOGY AND BIOCHEMISTRY, 58, 4, 786-787 1994/04 Refereed English Disclose to all
M HATAI, K TAKAHARA, H HASHI, KATO, I, Y YAOI M HATAI, K TAKAHARA, H HASHI, KATO, I, Y YAOI M HATAI, K TAKAHARA, H HASHI, KATO, I, Y YAOI EFFECTS OF FIBRONECTIN-TYPE-V COLLAGEN RECOMBINANT FUSION PROTEIN ON CELL-ADHESION AND CELL-PROLIFERATION EFFECTS OF FIBRONECTIN-TYPE-V COLLAGEN RECOMBINANT FUSION PROTEIN ON CELL-ADHESION AND CELL-PROLIFERATION EFFECTS OF FIBRONECTIN-TYPE-V COLLAGEN RECOMBINANT FUSION PROTEIN ON CELL-ADHESION AND CELL-PROLIFERATION CELL STRUCTURE AND FUNCTION, 17, 5, 293-300 CELL STRUCTURE AND FUNCTION, 17, 5, 293-300 CELL STRUCTURE AND FUNCTION, 17, 5, 293-300 1992/10 Refereed English Research paper(scientific journal) Disclose to all
K TAKAHARA, Y SATO, K OKAZAWA, N OKAMOTO, A NODA, Y YAOI, KATO, I K TAKAHARA, Y SATO, K OKAZAWA, N OKAMOTO, A NODA, Y YAOI, KATO, I K TAKAHARA, Y SATO, K OKAZAWA, N OKAMOTO, A NODA, Y YAOI, KATO, I COMPLETE PRIMARY STRUCTURE OF HUMAN COLLAGEN ALPHA-1(V) CHAIN COMPLETE PRIMARY STRUCTURE OF HUMAN COLLAGEN ALPHA-1(V) CHAIN COMPLETE PRIMARY STRUCTURE OF HUMAN COLLAGEN ALPHA-1(V) CHAIN JOURNAL OF BIOLOGICAL CHEMISTRY, 266, 20, 13124-13129 JOURNAL OF BIOLOGICAL CHEMISTRY, 266, 20, 13124-13129 JOURNAL OF BIOLOGICAL CHEMISTRY, 266, 20, 13124-13129 1991/07 Refereed English Research paper(scientific journal) Disclose to all
Y YAOI, K HASHIMOTO, K TAKAHARA, KATO, I Y YAOI, K HASHIMOTO, K TAKAHARA, KATO, I Y YAOI, K HASHIMOTO, K TAKAHARA, KATO, I INSULIN BINDS TO TYPE-V COLLAGEN WITH RETENTION OF MITOGENIC ACTIVITY INSULIN BINDS TO TYPE-V COLLAGEN WITH RETENTION OF MITOGENIC ACTIVITY INSULIN BINDS TO TYPE-V COLLAGEN WITH RETENTION OF MITOGENIC ACTIVITY EXPERIMENTAL CELL RESEARCH, 194, 2, 180-185 EXPERIMENTAL CELL RESEARCH, 194, 2, 180-185 EXPERIMENTAL CELL RESEARCH, 194, 2, 180-185 1991/06 Refereed English Research paper(scientific journal) Disclose to all
N NAKAMURA, H SUGINO, K TAKAHARA, C JIN, S FUKUSHIGE, K MATSUBARA N NAKAMURA, H SUGINO, K TAKAHARA, C JIN, S FUKUSHIGE, K MATSUBARA N NAKAMURA, H SUGINO, K TAKAHARA, C JIN, S FUKUSHIGE, K MATSUBARA ENDOGENOUS RETROVIRAL LTR DNA-SEQUENCES AS MARKERS FOR INDIVIDUAL HUMAN-CHROMOSOMES ENDOGENOUS RETROVIRAL LTR DNA-SEQUENCES AS MARKERS FOR INDIVIDUAL HUMAN-CHROMOSOMES ENDOGENOUS RETROVIRAL LTR DNA-SEQUENCES AS MARKERS FOR INDIVIDUAL HUMAN-CHROMOSOMES CYTOGENETICS AND CELL GENETICS, 57, 1, 18-22 CYTOGENETICS AND CELL GENETICS, 57, 1, 18-22 CYTOGENETICS AND CELL GENETICS, 57, 1, 18-22 1991 Refereed English Research paper(scientific journal) Disclose to all
Y YAOI, K HASHIMOTO, H KOITABASHI, K TAKAHARA, M ITO, KATO, I Y YAOI, K HASHIMOTO, H KOITABASHI, K TAKAHARA, M ITO, KATO, I Y YAOI, K HASHIMOTO, H KOITABASHI, K TAKAHARA, M ITO, KATO, I PRIMARY STRUCTURE OF THE HEPARIN-BINDING SITE OF TYPE-V COLLAGEN PRIMARY STRUCTURE OF THE HEPARIN-BINDING SITE OF TYPE-V COLLAGEN PRIMARY STRUCTURE OF THE HEPARIN-BINDING SITE OF TYPE-V COLLAGEN BIOCHIMICA ET BIOPHYSICA ACTA, 1035, 2, 139-145 BIOCHIMICA ET BIOPHYSICA ACTA, 1035, 2, 139-145 BIOCHIMICA ET BIOPHYSICA ACTA, 1035, 2, 139-145 1990/08 Refereed English Research paper(scientific journal) Disclose to all
K SHIOSAKI, Y MIYATSU, K TAKAHARA, H MIZOKAMI, F HAMADA, K MATSUBARA K SHIOSAKI, Y MIYATSU, K TAKAHARA, H MIZOKAMI, F HAMADA, K MATSUBARA K SHIOSAKI, Y MIYATSU, K TAKAHARA, H MIZOKAMI, F HAMADA, K MATSUBARA A YEAST SYSTEM FOR STABLE EXPRESSION OF HEPATITIS-B SURFACE-ANTIGEN A YEAST SYSTEM FOR STABLE EXPRESSION OF HEPATITIS-B SURFACE-ANTIGEN A YEAST SYSTEM FOR STABLE EXPRESSION OF HEPATITIS-B SURFACE-ANTIGEN JOURNAL OF BIOTECHNOLOGY, 14, 3-4, 411-422 JOURNAL OF BIOTECHNOLOGY, 14, 3-4, 411-422 JOURNAL OF BIOTECHNOLOGY, 14, 3-4, 411-422 1990/06 Refereed English Research paper(scientific journal) Disclose to all
K TAKAHARA, S FUKUSHIGE, T MUROTSU, Y ICHIHARA, T HAYANO, T ISHIHARA, K TAKAHASHI, K MATSUBARA K TAKAHARA, S FUKUSHIGE, T MUROTSU, Y ICHIHARA, T HAYANO, T ISHIHARA, K TAKAHASHI, K MATSUBARA K TAKAHARA, S FUKUSHIGE, T MUROTSU, Y ICHIHARA, T HAYANO, T ISHIHARA, K TAKAHASHI, K MATSUBARA ASSIGNMENT OF HUMAN PEPSINOGEN-C (PGC) GENE TO CHROMOSOME-6 ASSIGNMENT OF HUMAN PEPSINOGEN-C (PGC) GENE TO CHROMOSOME-6 ASSIGNMENT OF HUMAN PEPSINOGEN-C (PGC) GENE TO CHROMOSOME-6 CYTOGENETICS AND CELL GENETICS, 52, 1-2, 100-101 CYTOGENETICS AND CELL GENETICS, 52, 1-2, 100-101 CYTOGENETICS AND CELL GENETICS, 52, 1-2, 100-101 1989 Refereed English Disclose to all

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Title language:
Misc
Author Author(Japanese) Author(English) Title Title(Japanese) Title(English) Bibliography Bibliography(Japanese) Bibliography(English) Publication date Refereed paper Language Publishing type Disclose
高原 和彦, 長岡 孝治, 吉田 英雄, 斉藤 伸一郎, 高村 祥子, 司, 三宅 健介, 稲葉 カヨ 高原 和彦, 長岡 孝治, 吉田 英雄, 斉藤 伸一郎, 高村 祥子, 司, 三宅 健介, 稲葉 カヨ 高原 和彦, 長岡 孝治, 吉田 英雄, 斉藤 伸一郎, 高村 祥子, 司, 三宅 健介, 稲葉 カヨ マウスDC-SIGNホモログSIGNR1によるグラム陰性菌の認識とTLR4応答におよぼす影響 マウスDC-SIGNホモログSIGNR1によるグラム陰性菌の認識とTLR4応答におよぼす影響 マウスDC-SIGNホモログSIGNR1によるグラム陰性菌の認識とTLR4応答におよぼす影響 日本免疫学会総会・学術集会記録, 34, 288-288 日本免疫学会総会・学術集会記録, 34, 288-288 日本免疫学会総会・学術集会記録, 34, 288-288 2004/11 Japanese Disclose to all
山出 史也, 壬生 優子, 赤司 祥子, 高原 和彦, 三宅 健介, 木本 雅夫, 稲葉 カヨ 山出 史也, 壬生 優子, 赤司 祥子, 高原 和彦, 三宅 健介, 木本 雅夫, 稲葉 カヨ 山出 史也, 壬生 優子, 赤司 祥子, 高原 和彦, 三宅 健介, 木本 雅夫, 稲葉 カヨ 樹状細胞におけるRP105とTLR-4の発現 樹状細胞におけるRP105とTLR-4の発現 樹状細胞におけるRP105とTLR-4の発現 日本免疫学会総会・学術集会記録, 29, 146-146 日本免疫学会総会・学術集会記録, 29, 146-146 日本免疫学会総会・学術集会記録, 29, 146-146 1999/10 Japanese Disclose to all
JD Mott, K Takahara, MT Rosenbach, CL Thomas, S Lee, DS Greenspan, MJ Banda JD Mott, K Takahara, MT Rosenbach, CL Thomas, S Lee, DS Greenspan, MJ Banda JD Mott, K Takahara, MT Rosenbach, CL Thomas, S Lee, DS Greenspan, MJ Banda Novel matrix metalloproteinase inhibitor in human brain tumors Novel matrix metalloproteinase inhibitor in human brain tumors Novel matrix metalloproteinase inhibitor in human brain tumors FASEB JOURNAL, 11, 9, A1255-A1255 FASEB JOURNAL, 11, 9, A1255-A1255 FASEB JOURNAL, 11, 9, A1255-A1255 1997/07 English Summary of the papers read (international conference) Disclose to all
S Amano, K Takahara, DR Gerecke, T Nishiyama, S Lee, DS Greenspan, B Hogan, DE Birk, RE Burgeson S Amano, K Takahara, DR Gerecke, T Nishiyama, S Lee, DS Greenspan, B Hogan, DE Birk, RE Burgeson S Amano, K Takahara, DR Gerecke, T Nishiyama, S Lee, DS Greenspan, B Hogan, DE Birk, RE Burgeson The gamma-2 chain of laminin 5 is processed by BMP-1 and processing is essential to basement membrane assembly in vivo. The gamma-2 chain of laminin 5 is processed by BMP-1 and processing is essential to basement membrane assembly in vivo. The gamma-2 chain of laminin 5 is processed by BMP-1 and processing is essential to basement membrane assembly in vivo. JOURNAL OF INVESTIGATIVE DERMATOLOGY, 108, 4, 29-29 JOURNAL OF INVESTIGATIVE DERMATOLOGY, 108, 4, 29-29 JOURNAL OF INVESTIGATIVE DERMATOLOGY, 108, 4, 29-29 1997/04 English Summary of the papers read (international conference) Disclose to all
S Amano, K Takahara, D Gerecke, T Nishiyama, S Lee, DS Greenspan, RE Burgeson S Amano, K Takahara, D Gerecke, T Nishiyama, S Lee, DS Greenspan, RE Burgeson S Amano, K Takahara, D Gerecke, T Nishiyama, S Lee, DS Greenspan, RE Burgeson Bone morphogenetic protein-1 is the processing enzyme for laminin 5 in human keratinocytes. Bone morphogenetic protein-1 is the processing enzyme for laminin 5 in human keratinocytes. Bone morphogenetic protein-1 is the processing enzyme for laminin 5 in human keratinocytes. MOLECULAR BIOLOGY OF THE CELL, 7, 338-338 MOLECULAR BIOLOGY OF THE CELL, 7, 338-338 MOLECULAR BIOLOGY OF THE CELL, 7, 338-338 1996/12 English Summary of the papers read (international conference) Disclose to all
Title language:
Conference Activities & Talks
Title Title(Japanese) Title(English) Conference Conference(Japanese) Conference(English) Promotor Promotor(Japanese) Promotor(English) Date Language Assortment Disclose
微細な粒子/蛋白凝集体はそのサイズ・形状により異なる細胞内応答経路を活性化する 微細な粒子/蛋白凝集体はそのサイズ・形状により異なる細胞内応答経路を活性化する 広島醗酵会総会・公開講演会 広島醗酵会総会・公開講演会 広島醗酵会 広島醗酵会 2013/11/02 Japanese Oral presentation(invited, special) Disclose to all
粒子サイズによる細胞応答性の差異 粒子サイズによる細胞応答性の差異 京都環境ナノクラスター主催「ナノ材料の安全性・社会受容に関するシンポジウム」 京都環境ナノクラスター主催「ナノ材料の安全性・社会受容に関するシンポジウム」 2012 Japanese Oral presentation(invited, special) Disclose to all
Role of SIGN-related molecules in innate immune responses Role of SIGN-related molecules in innate immune responses Role of SIGN-related molecules in innate immune responses CREST Symposium CREST国際シンポジウム「獲得免疫と糖鎖生物学」 CREST Symposium 2009 English Oral presentation(invited, special) Disclose to all
Title language:
Books etc
Author Author(Japanese) Author(English) Title Title(Japanese) Title(English) Publisher Publisher(Japanese) Publisher(English) Publication date Language Type Disclose
高原 和彦 高原 和彦 京大発 フロンティア生命科学 京大発 フロンティア生命科学 講談社 講談社 2018/03 Japanese Contributor Disclose to all
高原 和彦 高原 和彦 Immune regulation though C-type lectin: Their roles in homeostasis and application C型レクチンによる生体応答制御 -恒常性の維持と応用- Immune regulation though C-type lectin: Their roles in homeostasis and application Clinical Immunology & Allergology 臨床免疫・アレルギー科 Clinical Immunology & Allergology 2016/08 Disclose to all
足立 匠, 高原 和彦, 稲葉 カヨ 足立 匠, 高原 和彦, 稲葉 カヨ 微細粒子物質による炎症惹起 微細粒子物質による炎症惹起 臨床免疫・アレルギー科 臨床免疫・アレルギー科 2013/12 Japanese Disclose to all
高原 和彦, 石黒 俊史 高原 和彦, 石黒 俊史 C-型レクチンDC-SIGNを介したIL-10産生と免疫制御. C-型レクチンDC-SIGNを介したIL-10産生と免疫制御. 臨床免疫・アレルギー科 臨床免疫・アレルギー科 2013/12 Japanese Disclose to all
高原 和彦 高原 和彦 樹状細胞に発現するCタイプレクチンDCIR(Dendritic cell immunoreceptor)の機能と生体における働き) 樹状細胞に発現するCタイプレクチンDCIR(Dendritic cell immunoreceptor)の機能と生体における働き) 臨床免疫アレルギー科 臨床免疫アレルギー科 2009 Japanese Disclose to all
高原 和彦 高原 和彦 樹状細胞み発現するC型レクチンの機能とシグナル伝達 樹状細胞み発現するC型レクチンの機能とシグナル伝達 実験医学 実験医学 2008 Japanese Disclose to all
長岡 孝治 長岡 孝治 マウスC型レクチンSIGNR1とその免疫応答における役割 マウスC型レクチンSIGNR1とその免疫応答における役割 臨床免疫 臨床免疫 2006 Japanese Disclose to all
高原 和彦 高原 和彦 樹状細胞上のC-タイプレクチン群とそのリガンド 樹状細胞上のC-タイプレクチン群とそのリガンド 科学評論社 科学評論社 2005 Japanese Disclose to all
高原 和彦 高原 和彦 樹状細胞におけるパターン認識レセプターとしてのレクチン 樹状細胞におけるパターン認識レセプターとしてのレクチン 臨床免疫 臨床免疫 2003 Japanese Disclose to all
高原 和彦 高原 和彦 樹状細胞による免疫寛容の誘導と維持 樹状細胞による免疫寛容の誘導と維持 細胞工学 細胞工学 2002 Japanese Disclose to all
高原 和彦 高原 和彦 樹状細胞の抗原プロセッシングと腫瘍免疫 樹状細胞の抗原プロセッシングと腫瘍免疫 医学の歩み 医学の歩み 2000 Japanese Disclose to all
高原 和彦 高原 和彦 樹状細胞による抗原ペプチドの提示とその腫瘍免疫への応用 樹状細胞による抗原ペプチドの提示とその腫瘍免疫への応用 現代医学 現代医学 2000 Japanese Disclose to all
高原 和彦 高原 和彦 抗腫瘍免疫療法における樹状細胞 抗腫瘍免疫療法における樹状細胞 最新医学 最新医学 1999 Japanese Disclose to all
高原 和彦 高原 和彦 生体防御における樹状細胞の役割と応用 生体防御における樹状細胞の役割と応用 バイオインダストリ-協会 バイオインダストリ-協会 1998 Japanese Disclose to all
高原 和彦 高原 和彦 BMP-1とI型プロコラーゲンC-プロテイナーゼ BMP-1とI型プロコラーゲンC-プロテイナーゼ 実験医学 実験医学 1996 Japanese Disclose to all
高原 和彦 高原 和彦 高原 和彦 Technical Study on Analysis of Double Stained Human Chromosomes Technical Study on Analysis of Double Stained Human Chromosomes Technical Study on Analysis of Double Stained Human Chromosomes "Flow cytometry and image analysis for clinical application" Elsevier Science Publishers B. V.,/,89-94 "Flow cytometry and image analysis for clinical application" Elsevier Science Publishers B. V.,/,89-94 "Flow cytometry and image analysis for clinical application" Elsevier Science Publishers B. V.,/,89-94 1991 English Disclose to all
高原 和彦 高原 和彦 人染色体のソーティング 人染色体のソーティング 細胞工学 細胞工学 1988 Japanese Disclose to all

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Title language:
Industrial Property Rights (Patent)
Inventor(s) Inventor(s) (Japanese) Inventor(s) (English) Title Title(Japanese) Title(English) Stage Patent number Date Disclose
Mammalian Tolloid-Like Gene and Protein Mammalian Tolloid-Like Gene and Protein 特許登録 特許US Issued Patent No. 5939321 1999 Disclose to all
インスリン結合阻害剤 インスリン結合阻害剤 特許公開 特開特開平11-092396 インスリン結合阻害剤 1999 Disclose to all
インスリン結合用担体 インスリン結合用担体 特許公開 特開特開平11-092404 1999 Disclose to all
逆転写酵素遺伝子 逆転写酵素遺伝子 特許公開 特開特開平07-039378 1995 Disclose to all
ヒトコラーゲンV型遺伝子 ヒトコラーゲンV型遺伝子 特許公開 特開特開平06-105687 1994 Disclose to all
機能性ポリペプチド 機能性ポリペプチド 特許公開 特開特開平05-097698 1993 Disclose to all
インスリン結合活性を有するポリペプチド インスリン結合活性を有するポリペプチド 特許公開 特開特開平02-209899 1990 Disclose to all
Title language:
Awards
Title(Japanese) Title(English) Organization name(Japanese) Organization name(English) Date
Outstanding Merit Award from International ImmunologyOutstanding Merit Award from International Immunology Outstanding Merit Award from International ImmunologyOutstanding Merit Award from International Immunology 日本免疫学会発行誌 2004
Outstanding Merit Award from International ImmunologyOutstanding Merit Award from International Immunology Outstanding Merit Award from International ImmunologyOutstanding Merit Award from International Immunology 日本免疫学会発行誌 2006
External funds: competitive funds and Grants-in-Aid for Scientific Research (Kakenhi)
Type Position Title(Japanese) Title(English) Period
奨励研究 Representative 炎症領域におけるTGF-β1のランゲルハンス細胞及び樹状細胞に対する影響 Effects of TGF-β1 on Langerhans cells and dendritics cells in inflammation 1998-1999
特定領域研究C(一般)(2) Representative マウス系統間における皮膚炎症応答の違いとアレルギー獲得性の相関 Allergy susceptibility and skin inflammatory responses in mouse strains 1999-1999
基盤研究(B) Assignment ミエロイド系樹状細胞とリンパ球系樹状細胞 Myeloid dendritic cells and lymphoid dendritic cells 1999-2001
基盤研究C Representative 皮膚ならび粘膜組織におけるマウスLangerin陽性細胞の動態と機能 Migration and function of Langerin-expressing cells in skin and mucosa 2001-2002
基盤研究(B) Assignment 免疫監視・制御細胞としての樹状細胞機能の解析 Function of Dendritic cells as Sentinel and Regulator 2001-2003
特定領域研究(B) Assignment 免疫寛容の誘導・維持と破綻における樹状細胞の機能と作用メカニズムの解析 2001-2005
特定領域研究(A) Assignment 抗原提示細胞によるT細胞活性化機構 2001-2001
特定領域研究(C) Assignment 抗腫瘍免疫応答における樹状細胞の役割 2001-2001
基盤研究C Representative Langerin分子による外来微生物等の糖鎖認識とその機構 Recognition of saccharides on microbes by Langerin 2003-2004
特定領域研究(2) Representative マウスレクチンSIGNR1の微生物認識およびTLR4との相互作用 Recognition of microbes by SIGNR1 and co-operation with TLR4 2004-2005
基盤研究C Representative 免疫系細胞に発現するC-型レクチンによる微生物認識とTLR応答への関与 Effects of C-type lectin expressing in immune cells on TLR response during microbe recognition 2005-2006
特定領域研究(2) Representative 微生物感染におけるSIGNR1の働き Functions of SIGNRI1 during microbe infection 2007-2008
基盤研究C Representative マウスレクチンSIGNRファミリーの機能解析 Functional analyses of mouse lectin SIGNR family 2007-2008
CREST Assignment マウスマクロファージ/DCサブセットの応答における均衡維持機構 2008-2013
萌芽研究 Assignment ナノ物質に対する細胞応答性とその差異の検討 2008-2009
基盤研究(C) Representative レクチン分子の発現を指標としたマクロファージサブセットの生体内動態 Dynamics of macrophage subsets in vivo based on expression of lectin molecule 2009-2011
特定領域研究 Representative 糖鎖認識におけるSIGNR1と他のファミリー分子における差異の解析 Different properties of SIGNR family in recognition of saccharides 2009-2010
基盤研究(C) Representative C型レクチンを介した微生物多糖による免疫応答制御 2013-2016
基盤研究(C) Representative C型レクチンを介した微生物多糖による免疫応答制御 2013/04/01-2016/03/31
挑戦的萌芽 Assignment 生体内不溶物質によるサイズ依存的なIL-1beta産生経路の存在 2013/04/01-2015/03/31
基盤研究(C) Representative 微生物糖鎖を用いた免疫制御 2016/04/01-2019/03/31
基盤研究(C) Representative 微生物糖鎖を用いた免疫制御 (平成28年度分) 2016/04/01-2017/03/31
基盤研究(C) Representative 微生物糖鎖を用いた免疫制御 (平成29年度分) 2017/04/01-2018/03/31
基盤研究(C) Representative 微生物糖鎖を用いた免疫制御 (平成30年度分) 2018/04/01-2019/03/31

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External funds: other than those above
System Main person Title(Japanese) Title(English) Period
ホクト生物科学振興財団 高原 和彦 パターン認識受容体TLRとレクチンの微生物認識における共同作用 2006-2007
京都大学コアステージバックアップ研究費 高原 和彦 C型レクチンによるC. albicansの認識と免疫制御 2012-2012
清水免疫学・神経科学振興財団研究助成 高原 和彦 シリカ粒子によるサイズ依存的なIL-1β産生経路の存在 2013-2014
GAPファンドプログラム 高原 和彦 免疫抑制性サイトカインIL-10産生を誘導する新規糖鎖の開発 2018/12/1-2019/11/30
清水免疫学・神経科学振興財団研究助成 高原 和彦 自然免疫レセプターDectin-1は個体最初のT細胞発生に必須である 2020-2021
Teaching subject(s)
Name(Japanese) Name(English) Term Department Period
免疫生物学 前期 理学部 2011/04-2012/03
生物学実習D (2) 後期 理学部 2011/04-2012/03
生物学セミナ-B (5) 後期 理学部 2011/04-2012/03
生物科学課題研究7 通年 理学部 2011/04-2012/03
免疫生物学 Immunobiology 前期 理学部 2012/04-2013/03
生物学セミナ-B Seminars in Biological Science B 後期 理学部 2012/04-2013/03
生物学実習D Laboratory work in Biological Science D 後期 理学部 2012/04-2013/03
生物科学課題研究7 Special Study CourseII(Biological Sciences) 7 通年 理学部 2012/04-2013/03
免疫生物学 Immunobiology 前期 理学部 2013/04-2014/03
生物学実習D Laboratory work in Biological Science D 後期 理学部 2013/04-2014/03
生物学セミナ−B Seminars in Biological Science B 後期 理学部 2013/04-2014/03
生物科学課題研究7 Special Study CourseII(Biological Sciences) 7 通年 理学部 2013/04-2014/03
疾患・免疫生命科学特論 Advanced Course in Immunology and Human Disorders 前期集中 生命科学研究科 2013/04-2014/03
生命科学概論II Study of Life Science II 後期 全学共通科目 2013/04-2014/03
免疫生物学 Immunobiology 前期 理学部 2014/04-2015/03
生物学実習D Laboratory work in Biological Science D 後期 理学部 2014/04-2015/03
生物学セミナ-B Seminars in Biological Science B 後期 理学部 2014/04-2015/03
生物科学課題研究7 Special Study CourseII(Biological Sciences) 7 通年 理学部 2014/04-2015/03
疾患・免疫生命科学特論 Advanced Course in Immunology and Human Disorders 前期集中 生命科学研究科 2014/04-2015/03
生命科学概論II Study of Life Science II 後期 全学共通科目 2014/04-2015/03
免疫生物学 Immunobiology 前期 理学部 2015/04-2016/03
生体防御学概論 Introduction to Self-defense mechanisms 前期 総合生存学館 2015/04-2016/03
生命科学概論II Study of Life Science II 後期 全学共通科目 2015/04-2016/03
生物学セミナ-B Seminars in Biological Science B 後期 理学部 2015/04-2016/03
生物学実習D Laboratory work in Biological Science D 後期 理学部 2015/04-2016/03
生物科学課題研究7 Special Study CourseII(Biological Sciences) 7 通年 理学部 2015/04-2016/03
疾患・免疫生命科学特論 Advanced Course in Immunology and Human Disorders 後期集中 生命科学研究科 2015/04-2016/03
免疫生物学 Immunobiology 前期 理学部 2016/04-2017/03
特別実験及び演習 Experimental Course and Seminar 前期不定 生命科学研究科 2016/04-2017/03
特別実験及び演習 Experimental Course and Seminar 後期不定 生命科学研究科 2016/04-2017/03
生体防御学概論 Introduction to Self-defense mechanisms 前期 総合生存学館 2016/04-2017/03
生物学セミナ-B Seminars in Biological Science B 後期 理学部 2016/04-2017/03
生物学実習D Laboratory work in Biological Science D 後期集中 理学部 2016/04-2017/03
生物・生命科学入門 Introduction to Biology and Life Science 前期 全学共通科目 2016/04-2017/03
生物科学課題研究7 Special Study CourseII(Biological Sciences) 7 通年 理学部 2016/04-2017/03
疾患・免疫生命科学特論 Advanced Course in Immunology and Human Disorders 前期集中 生命科学研究科 2016/04-2017/03
高次生命科学特別演習 Advanced Experiments in Systemic Life Sciences 前期不定 生命科学研究科 2016/04-2017/03
高次生命科学特別演習 Advanced Experiments in Systemic Life Sciences 後期不定 生命科学研究科 2016/04-2017/03
免疫生物学 Immunobiology 前期 理学部 2017/04-2018/03
特別実験及び演習 Experimental Course and Seminar 前期不定 生命科学研究科 2017/04-2018/03
特別実験及び演習 Experimental Course and Seminar 後期不定 生命科学研究科 2017/04-2018/03
生体防御学概論 Introduction to Self-defense mechanisms 前期 総合生存学館 2017/04-2018/03
生物学セミナ-B Seminars in Biological Science B 後期 理学部 2017/04-2018/03
生物学実習D Laboratory work in Biological Science D 後期集中 理学部 2017/04-2018/03
生物科学課題研究7 Special Study CourseII(Biological Sciences) 7 通年 理学部 2017/04-2018/03
疾患・免疫生命科学特論 Advanced Course in Immunology and Human Disorders 後期集中 生命科学研究科 2017/04-2018/03
高次生命科学特別演習 Advanced Experiments in Systemic Life Sciences 前期不定 生命科学研究科 2017/04-2018/03
高次生命科学特別演習 Advanced Experiments in Systemic Life Sciences 後期不定 生命科学研究科 2017/04-2018/03
免疫生物学 Immunobiology 前期 理学部 2018/04-2019/03
特別実験及び演習A Experimental Course and Seminar A 前期不定 生命科学研究科 2018/04-2019/03
特別実験及び演習A Experimental Course and Seminar A 後期不定 生命科学研究科 2018/04-2019/03
特別実験及び演習B Experimental Course and Seminar B 前期不定 生命科学研究科 2018/04-2019/03
特別実験及び演習B Experimental Course and Seminar B 後期不定 生命科学研究科 2018/04-2019/03
特別実験及び演習C Experimental Course and Seminar C 前期不定 生命科学研究科 2018/04-2019/03
特別実験及び演習C Experimental Course and Seminar C 後期不定 生命科学研究科 2018/04-2019/03
特別実験及び演習D Experimental Course and Seminar D 前期不定 生命科学研究科 2018/04-2019/03
特別実験及び演習D Experimental Course and Seminar D 後期不定 生命科学研究科 2018/04-2019/03
特別実験及び演習 Experimental Course and Seminar 前期不定 生命科学研究科 2018/04-2019/03
特別実験及び演習 Experimental Course and Seminar 後期不定 生命科学研究科 2018/04-2019/03
生体防御学概論 Introduction to Self-defense mechanisms 前期 総合生存学館 2018/04-2019/03
生物学セミナ-B Seminars in Biological Science B 後期 理学部 2018/04-2019/03
生物学実習D Laboratory work in Biological Science D 後期集中 理学部 2018/04-2019/03
生物・生命科学入門 Introduction to Biology and Life Science 前期 全学共通科目 2018/04-2019/03
生物科学課題研究7 Special Study CourseII(Biological Sciences) 7 通年 理学部 2018/04-2019/03
疾患・免疫生命科学特論 Advanced Course in Immunology and Human Disorders 前期集中 生命科学研究科 2018/04-2019/03
高次生命科学特別演習 Advanced Experiments in Systemic Life Sciences 前期不定 生命科学研究科 2018/04-2019/03
高次生命科学特別演習 Advanced Experiments in Systemic Life Sciences 後期不定 生命科学研究科 2018/04-2019/03
免疫生物学 Immunobiology 前期 理学部 2019/04-2020/03
特別実験及び演習A Experimental Course and Seminar A 前期不定 生命科学研究科 2019/04-2020/03
特別実験及び演習A Experimental Course and Seminar A 後期不定 生命科学研究科 2019/04-2020/03
特別実験及び演習B Experimental Course and Seminar B 前期不定 生命科学研究科 2019/04-2020/03
特別実験及び演習B Experimental Course and Seminar B 後期不定 生命科学研究科 2019/04-2020/03
特別実験及び演習C Experimental Course and Seminar C 前期不定 生命科学研究科 2019/04-2020/03
特別実験及び演習C Experimental Course and Seminar C 後期不定 生命科学研究科 2019/04-2020/03
特別実験及び演習D Experimental Course and Seminar D 前期不定 生命科学研究科 2019/04-2020/03
特別実験及び演習D Experimental Course and Seminar D 後期不定 生命科学研究科 2019/04-2020/03
特別実験及び演習 Experimental Course and Seminar 前期不定 生命科学研究科 2019/04-2020/03
特別実験及び演習 Experimental Course and Seminar 後期不定 生命科学研究科 2019/04-2020/03
生体防御学概論 Introduction to Self-defense mechanisms 前期 総合生存学館 2019/04-2020/03
生物学セミナ-B Seminars in Biological Science B 後期 理学部 2019/04-2020/03
生物学実習D Laboratory work in Biological Science D 後期集中 理学部 2019/04-2020/03
生物科学課題研究7 Special Study CourseII(Biological Sciences) 7 通年 理学部 2019/04-2020/03
疾患・免疫生命科学特論 Advanced Course in Immunology and Human Disorders 前期集中 生命科学研究科 2019/04-2020/03
高次生命科学特別演習 Advanced Experiments in Systemic Life Sciences 前期不定 生命科学研究科 2019/04-2020/03
高次生命科学特別演習 Advanced Experiments in Systemic Life Sciences 後期不定 生命科学研究科 2019/04-2020/03
免疫生物学 Immunobiology 前期 理学部 2020/04-2021/03
(生体応答学)特別実験及び演習A Experimental Course and Seminar 前期不定 生命科学研究科 2020/04-2021/03
(生体応答学)特別実験及び演習B Experimental Course and Seminar 前期不定 生命科学研究科 2020/04-2021/03
(生体応答学)特別実験及び演習C Experimental Course and Seminar 前期不定 生命科学研究科 2020/04-2021/03
(生体応答学)特別実験及び演習D Experimental Course and Seminar 前期不定 生命科学研究科 2020/04-2021/03
(生体応答学)特別実験及び演習A Experimental Course and Seminar 後期不定 生命科学研究科 2020/04-2021/03
(生体応答学)特別実験及び演習B Experimental Course and Seminar 後期不定 生命科学研究科 2020/04-2021/03
(生体応答学)特別実験及び演習C Experimental Course and Seminar 後期不定 生命科学研究科 2020/04-2021/03
(生体応答学)特別実験及び演習D Experimental Course and Seminar 後期不定 生命科学研究科 2020/04-2021/03
(生体応答学)高次生命科学特別演習 Advanced Experiments in Systemic Life Sciences 前期不定 生命科学研究科 2020/04-2021/03
(生体応答学)高次生命科学特別演習 Advanced Experiments in Systemic Life Sciences 後期不定 生命科学研究科 2020/04-2021/03
生体防御学概論 Introduction to Self-defense mechanisms 前期 総合生存学館 2020/04-2021/03
生物学セミナ-B (5) Seminars in Biological Science B 後期 理学部 2020/04-2021/03
生物学実習D (2) Laboratory Work in Biological Science D 後期集中 理学部 2020/04-2021/03
生物・生命科学入門 Introduction to Biology and Life Science 前期 全学共通科目 2020/04-2021/03
生物科学課題研究7 Special Study CourseII(Biological Sciences) 7 通年 理学部 2020/04-2021/03
疾患・免疫生命科学特論 Advanced Course in Immunology and Human Disorders 後期集中 生命科学研究科 2020/04-2021/03

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School management (title, position)
Title Period
京都大学教務事務電算管理運営委員会 委員 2013/04/01-2017/03/31
環境管理専門委員会有機廃液情報管理小委員会 委員 2013/04/01-2015/03/31
京都大学動物実験委員会 委員 2014/10/01-2016/09/30
京都大学教務事務電算管理運営委員会 委員 2017/04/01-2019/03/31
環境管理専門委員会有機廃液情報管理小委員会委員 2017/04/01-2019/03/31
京都大学教務事務電算管理運営委員会 委員 2019/04/01-2021/03/31
Faculty management (title, position)
Title Period
図書委員会委員 2003/04/01-
安全・環境保全委員会委員 2016/04/01-
データ保全委員会委員 2015/10/01-
化学物質管理小委員会委員 2017/04/01-
特別管理産業廃棄物管理責任者 2007/02/08-
SPFマウス実験室運営委員会委員 2019/04/01-
SPFマウス実験室管理委員会委員 2019/04/01-
衛生管理者 2020/04/01-