江藤 浩之

Last Update: 2015/07/10 18:00:00

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Name(Kanji/Kana/Abecedarium Latinum)
江藤 浩之/エトウ コウジ/Koji Eto
Primary department(Org1/Job title)
iPS細胞研究所/Professor
Affiliated programs (koza)
Org1 Job title
Graduate Schools Medicine Professor
Graduate Schools Medicine Professor
Academic degree
Field(Japanese) Field(English) University(Japanese) University(English) Method
博士(医学) 山梨医科大学
Research Topics
(Japanese)
iPS細胞を用いた輸血製剤供給システムの開発と臨床試験
Overview of your research
(Japanese)
多細胞生物は非対称性分裂によって多様な細胞を産生しながら発生し、個体を形成します。血液を一生にわたって供給している造血幹細胞や各種の血液系譜前駆細胞もまた非対称性分裂によって多種類の血液細胞を産生すると考えられています。幹細胞システムを維持するためには自己複製と分化が必要であり、この両方を同時に可能にするのが非対称性自己複製分裂です。こうした機構の分子機序の解明を継続することで、私たちはヒト多能性幹細胞から効率よく血小板や造血幹細胞をはじめとする各種血液細胞を誘導する技術を確立し、献血に依存しない輸血システムの実現および遺伝子治療を目指した基礎研究・技術改良を推進していきます。 iPS細胞研究所は、再生医療の実現化を目指して様々な患者に対応できるiPS細胞の樹立を行ってバンク化する計画を推進しています。私たちは、iPS細胞に限定せず,iPS細胞をソースにした血小板や赤血球を大量かつ一定の品質で供給できるようにするためのバンクシステムの構築を目指します。そのために、従来の遺伝情報ネットワーク以外のエピゲノム情報を解析・応用し、特定の細胞系譜がヒト多能性幹細胞から生み出され維持されるための分子機構を明らかにしていきたいと考えています。
Published Papers > Published Papers
(文系研究者の一般的な論文集への寄稿や単行本の分担執筆などは「著書等」を参照してください)
Authors Title Bibliography Date Peer-Review Language
M. Ochiai; N. Yokoyama; K. Eto; A. Oshima; Y. Koyama; S. Takeshita; T. Isshiki; T. Sato Aggressive diagnostic and therapeutic approach for acute coronary syndrome Journal of Cardiology,33,SUPPL. 1,23-29 1999 Refereed Japanese
J. Ishihara; T. Umemoto; M. Yamato; Y. Shiratsuchi; S. Takaki; B.G. Petrich; H. Nakauchi; K. Eto; T. Kitamura; T. Okano Nov/CCN3 regulates long-term repopulating activity of murine hematopoietic stem cells via integrin αvβ3 International Journal of Hematology 2014 Refereed English
T. Higuchi; S. Kawagoe; M. Otsu; Y. Shimada; H. Kobayashi; R. Hirayama; K. Eto; H. Ida; T. Ohashi; H. Nakauchi; Y. Eto The generation of induced pluripotent stem cells (iPSCs) from patients with infantile and late-onset types of Pompe disease and the effects of treatment with acid-α-glucosidase in Pompe\\'s iPSCs Molecular Genetics and Metabolism 2014 Refereed English
N. Hirata; M. Nakagawa; Y. Fujibayashi; K. Yamauchi; A. Murata; I. Minami; M. Tomioka; T. Kondo; T.-F. Kuo; H. Endo; H. Inoue; S.-I. Sato; S. Ando; Y. Kawazoe; K. Aiba; K. Nagata; E. Kawase; Y.-T. Chang; H. Suemori; K. Eto; H. Nakauchi; S. Yamanaka; N. Nakatsuji; K. Ueda; M. Uesugi A Chemical Probe that Labels Human Pluripotent Stem Cells Cell Reports,6,6,1165-1174 2014 Refereed English
S. Nakamura; N. Takayama; S. Hirata; H. Seo; H. Endo; K. Ochi; K.-I. Fujita; T. Koike; K.-I. Harimoto; T. Dohda; A. Watanabe; K. Okita; N. Takahashi; A. Sawaguchi; S. Yamanaka; H. Nakauchi; S. Nishimura; K. Eto Expandable megakaryocyte cell lines enable clinically applicable generation of platelets from human induced pluripotent stem cells Cell Stem Cell,14,4,535-548 2014 Refereed English
A. Oda; K. Eto WASPs and WAVEs: From molecular function to physiology in hematopoietic cells Seminars in Cell and Developmental Biology,24,4,308-313 2013/04 Refereed English
T. Nishimura; S. Kaneko; A. Kawana-Tachikawa; Y. Tajima; H. Goto; D. Zhu; K. Nakayama-Hosoya; S. Iriguchi; Y. Uemura; T. Shimizu; N. Takayama; D. Yamada; K. Nishimura; M. Ohtaka; N. Watanabe; S. Takahashi; A. Iwamoto; H. Koseki; M. Nakanishi; K. Eto; H. Nakauchi Generation of rejuvenated antigen-specific T cells by reprogramming to pluripotency and redifferentiation Cell Stem Cell,12,1,114-126 2013 Refereed English
Y. Nakajima-Takagi; M. Osawa; M. Oshima; H. Takagi; S. Miyagi; M. Endoh; T.A. Endo; N. Takayama; K. Eto; T. Toyoda; H. Koseki; H. Nakauchi; A. Iwama Role of SOX17 in hematopoietic development from human embryonic stem cells Blood,121,3,447-458 2013 Refereed English
Y. Nakagawa; S. Nakamura; M. Nakajima; H. Endo; T. Dohda; N. Takayama; H. Nakauchi; F. Arai; T. Fukuda; K. Eto Two differential flows in a bioreactor promoted platelet generation from human pluripotent stem cell-derived megakaryocytes Experimental Hematology,41,8,742-748 2013 Refereed English
S. Hirata; N. Takayama; R. Jono-Ohnishi; H. Endo; S. Nakamura; T. Dohda; M. Nishi; Y. Hamazaki; E.-I. Ishii; S. Kaneko; M. Otsu; H. Nakauchi; S. Kunishima; K. Eto Congenital amegakaryocytic thrombocytopenia iPS cells exhibit defective MPL-mediated signaling Journal of Clinical Investigation,123,9,3802-3814 2013 Refereed English
T. Saito; F. Yano; D. Mori; S. Ohba; H. Hojo; M. Otsu; K. Eto; H. Nakauchi; S. Tanaka; U.-I. Chung; H. Kawaguchi Generation of Col2a1-EGFP iPS Cells for Monitoring Chondrogenic Differentiation PLoS ONE,8,9 2013 Refereed English
S. Nishimura; I. Manabe; S. Takaki; M. Nagasaki; M. Otsu; H. Yamashita; J. Sugita; K. Yoshimura; K. Eto; I. Komuro; T. Kadowaki; R. Nagai Adipose natural regulatory B cells negatively control adipose tissue inflammation Cell Metabolism,18,5,759-766 2013 Refereed English
S.-I. Hirose; N. Takayama; S. Nakamura; K. Nagasawa; K. Ochi; S. Hirata; S. Yamazaki; T. Yamaguchi; M. Otsu; S. Sano; N. Takahashi; A. Sawaguchi; M. Ito; T. Kato; H. Nakauchi; K. Eto Immortalization of erythroblasts by c-MYC and BCL-XL enables large-scale erythrocyte production from human pluripotent stem cells Stem Cell Reports,1,6,499-508 2013 Refereed English
K. Yamamizu; T. Matsunaga; S. Katayama; H. Kataoka; N. Takayama; K. Eto; S.-I. Nishikawa; J.K. Yamashita PKA/CREB signaling triggers initiation of endothelial and hematopoietic cell differentiation via Etv2 induction Stem Cells,30,4,687-696 2012/04 Refereed English
N. Takayama; K. Eto In vitro generation of megakaryocytes and platelets from human embryonic stem cells and induced pluripotent stem cells Methods in Molecular Biology,788,205-217 2012 Refereed English
T. Umemoto; M. Yamato; J. Ishihara; Y. Shiratsuchi; M. Utsumi; Y. Morita; H. Tsukui; M. Terasawa; T. Shibata; K. Nishida; Y. Kobayashi; B.G. Petrich; H. Nakauchi; K. Eto; T. Okano Integrin-αvβ3 regulates thrombopoietin-mediated maintenance of hematopoietic stem cells Blood,119,1,83-94 2012 Refereed English
S. Nishimura; I. Manabe; M. Nagasaki; S. Kakuta; Y. Iwakura; N. Takayama; J. Ooehara; M. Otsu; A. Kamiya; B.G. Petrich; T. Urano; T. Kadono; S. Sato; A. Aiba; H. Yamashita; S. Sugiura; T. Kadowaki; H. Nakauchi; K. Eto; R. Nagai In vivo imaging visualizes discoid platelet aggregations without endothelium disruption and implicates contribution of inflammatory cytokine and integrin signaling Blood,119,8,e45-e56 2012 Refereed English
K. Kumano; S. Arai; M. Hosoi; K. Taoka; N. Takayama; M. Otsu; G. Nagae; K. Ueda; K. Nakazaki; Y. Kamikubo; K. Eto; H. Aburatani; H. Nakauchi; M. Kurokawa Generation of induced pluripotent stem cells from primary chronic myelogenous leukemia patient samples Blood,119,26,6234-6242 2012 Refereed English
K. Eto Guest editorial: The contribution of pluripotent stem cells to blood cells International Journal of Hematology,95,6,599-600 2012 Refereed English
J.-R. Kim-Kaneyama; A. Miyauchi; X.-F. Lei; S. Arita; T. Mino; N. Takeda; K. Kou; K. Eto; T. Yoshida; T. Miyazaki; S. Shioda; A. Miyazaki Identification of Hic-5 as a novel regulatory factor for integrin αIIbβ3 activation and platelet aggregation in mice Journal of Thrombosis and Haemostasis,10,9,1867-1874 2012 Refereed English
N. Takayama; K. Eto Pluripotent stem cells reveal the developmental biology of human megakaryocytes and provide a source of platelets for clinical application Cellular and Molecular Life Sciences,69,20,3419-3428 2012 Refereed English
Eto K. Novel therapeutic strategy for hematological diseases using iPS cell-banking Rinsho Ketsueki 53(7):658-663 2012 Refereed English
S. Kunishima; H. Kashiwagi; M. Otsu; N. Takayama; K. Eto; M. Onodera; Y. Miyajima; Y. Takamatsu; J. Suzumiya; K. Matsubara; Y. Tomiyama; H. Saito Heterozygous ITGA2B R995W mutation inducing constitutive activation of the αIIbβ3 receptor affects proplatelet formation and causes congenital macrothrombocytopenia Blood,117,20,5479-5484 2011 Refereed English
N. Takayama; K. Eto; H. Nakauchi [Potential usefulness of human iPS cells on the generation of platelets]. Nihon rinsho. Japanese journal of clinical medicine,69,12,2161-2165 2011 Refereed English
H. Takizawa; S. Nishimura; N. Takayama; A. Oda; H. Nishikii; Y. Morita; S. Kakinuma; S. Yamazaki; S. Okamura; N. Tamura; S. Goto; A. Sawaguchi; I. Manabe; K. Takatsu; H. Nakauchi; S. Takaki; K. Eto Lnk regulates integrin αIIbβ3 outside-in signaling in mouse platelets, leading to stabilization of thrombus development in vivo Journal of Clinical Investigation,120,1,179-190 2010 Refereed English
K. Suzuki-Inoue; O. Inoue; G. Ding; S. Nishimura; K. Hokamura; K. Eto; H. Kashiwagi; Y. Tomiyama; Y. Yatomi; K. Umemura; Y. Shin; M. Hirashima; Y. Ozaki Essential in vivo roles of the C-type lectin receptor CLEC-2: Embryonic/neonatal lethality of CLEC-2-deficient mice by blood/lymphatic misconnections and impaired thrombus formation of CLEC-2-deficient platelets Journal of Biological Chemistry,285,32,24494-24507 2010 Refereed English
Y. Hayashi; T. Chan; M. Warashina; M. Fukuda; T. Ariizumi; K. Okabayashi; N. Takayama; M. Otsu; K. Eto; M.K. Furue; T. Michiue; K. Ohnuma; H. Nakauchi; M. Asashima Reduction of n-glycolylneuraminic acid in human induced pluripotent stem cells generated or cultured under feeder- and serum-free defined conditions PLoS ONE,5,11 2010 Refereed English
N. Takayama; S. Nishimura; S. Nakamura; T. Shimizu; R. Ohnishi; H. Endo; T. Yamaguchi; M. Otsu; K. Nishimura; M. Nakanishi; A. Sawaguchi; R. Nagai; K. Takahashi; S. Yamanaka; H. Nakauchi; K. Eto Transient activation of c-MYC expression is critical for efficient platelet generation from human induced pluripotent stem cells Journal of Experimental Medicine,207,13,2817-2830 2010 Refereed English
S. Yamazaki; A. Iwama; S.-I. Takayanagi; K. Eto; H. Ema; H. Nakauchi TGF- <sup>2</sup> as a candidate bone marrow niche signal to induce hematopoietic stem cell hibernation Blood,113,6,1250-1256 2009 Refereed English
K. Matsumoto; T. Isagawa; T. Nishimura; T. Ogaeri; K. Eto; S. Miyazaki; J.-I. Miyazaki; H. Aburatani; H. Nakauchi; H. Ema Stepwise development of hematopoietic stem cells from embryonic stem cells PLoS ONE,4,3 2009 Refereed English
T. Ogaeri; K. Eto; M. Otsu; H. Ema; H. Nakauchi The actin polymerization regulator WAVE2 is required for early bone marrow repopulation by hematopoietic stem cells Stem Cells,27,5,1120-1129 2009 Refereed English
S. Nishimura; I. Manabe; M. Nagasaki; K. Eto; H. Yamashita; M. Ohsugi; M. Otsu; K. Hara; K. Ueki; S. Sugiura; K. Yoshimura; T. Kadowaki; R. Nagai CD8<sup>+</sup> effector T cells contribute to macrophage recruitment and adipose tissue inflammation in obesity Nature Medicine,15,8,914-920 2009 Refereed English
M. Okabe; M. Otsu; D.H. Ahn; T. Kobayashi; Y. Morita; Y. Wakiyama; M. Onodera; K. Eto; H. Ema; H. Nakauchi Definitive proof for direct reprogramming of hematopoietic cells to pluripotency Blood,114,9,1764-1767 2009 Refereed English
T. Oki; K. Eto; K. Izawa; Y. Yamanishi; N. Inagaki; J. Frampton; T. Kitamura; J. Kitaura Evidence that integrin αIIbβ3-dependent interaction of mast cells with fibrinogen exacerbates chronic inflammation Journal of Biological Chemistry,284,45,31463-31472 2009 Refereed English
S. Tamaru; K. Kitajima; T. Nakano; K. Eto; A. Yazaki; T. Kobayashi; T. Matsumoto; H. Wada; N. Katayama; M. Nishikawa Calyculin A retraction of mature megakaryocytes proplatelets from embryonic stem cells Biochemical and Biophysical Research Communications,366,3,763-768 2008 Refereed English
N. Takayama; H. Nishikii; J. Usui; H. Tsukui; A. Sawaguchi; T. Hiroyama; K. Eto; H. Nakauchi Generation of functional platelets from human embryonic stem cells in vitro via ES-sacs, VEGF-promoted structures that concentrate hematopoietic progenitors Blood,111,11,5298-5306 2008 Refereed English
H. Nishikii; K. Eto; N. Tamura; K. Hattori; B. Heissig; T. Kanaji; A. Sawaguchi; S. Goto; J. Ware; H. Nakauchi Metalloproteinase regulation improves in vitro generation of efficacious platelets from mouse embryonic stem cells Journal of Experimental Medicine,205,8,1917-1927 2008 Refereed English
H. Takizawa; K. Eto; A. Yoshikawa; H. Nakauchi; K. Takatsu; S. Takaki Growth and maturation of megakaryocytes is regulated by Lnk/Sh2b3 adaptor protein through crosstalk between cytokine- and integrin-mediated signals Experimental Hematology,36,7,897-906 2008 Refereed English
S. Yamazaki; A. Iwama; Y. Morita; K. Eto; H. Ema; H. Nakauchi Cytokine signaling, lipid raft clustering, and HSC hibernation Annals of the New York Academy of Sciences,1106,54-63 2007 Refereed English
K. Eto; H. Nishikii; T. Ogaeri; S. Suetsugu; A. Kamiya; T. Kobayashi; D. Yamazaki; A. Oda; T. Takenawa; H. Nakauchi The WAVE2/Abi1 complex differentially regulates megakaryocyte development and spreading: Implications for platelet biogenesis and spreading machinery Blood,110,10,3637-3647 2007 Refereed English
A. Soriani; B. Moran; M. De Virgilio; T. Kawakami; A. Altman; C. Lowell; K. Eto; S.J. Shattil A role for PKCθ in outside-in α<sub>IIb</sub> β<sub>3</sub> signaling Journal of Thrombosis and Haemostasis,4,3,648-655 2006 Refereed English
S.-I. Takayanagi; T. Hiroyama; S. Yamazaki; T. Nakajima; Y. Morita; J. Usui; K. Eto; T. Motohashi; K. Shiomi; K. Keino-Masu; M. Masu; Y. Oike; S. Mori; N. Yoshida; A. Iwama; H. Nakauchi Genetic marking of hematopoietic stem and endothelial cells: Identification of the Tmtsp gene encoding a novel cell surface protein with the thrombospondin-1 domain Blood,107,11,4317-4325 2006 Refereed English
S. Yamazaki; A. Iwama; S.-I. Takayanagi; Y. Morita; K. Eto; H. Ema; H. Nakauchi Cytokine signals modulated via lipid rafts mimic niche signals and induce hibernation in hematopoietic stem cells EMBO Journal,25,15,3515-3523 2006 Refereed English
T. Oki; J. Kitaura; K. Eto; Y. Lu; M. Maeda-Yamamoto; N. Inagaki; H. Nagai; Y. Yamanishi; H. Nakajina; H. Kumagai; T. Kitamura Integrin α<sub>IIb</sub>β<sub>3</sub> induces the adhesion and activation of mast cells through interaction with fibrinogen Journal of Immunology,176,1,52-60 2006 Refereed English
C.S. Buensuceso; A. Obergfell; A. Soriani; K. Eto; W.B. Kiosses; E.G. Arias-Salgado; T. Kawakami; S.J. Shattil Regulation of outside-in signaling in platelets by integrin-associated protein kinase Cβ Journal of Biological Chemistry,280,1,644-653 2005 Refereed English
A. Matsubara; A. Iwama; S. Yamazaki; C. Furuta; R. Hirasawa; Y. Morita; M. Osawa; T. Motohashi; K. Eto; H. Ema; T. Kitamura; D. Vestweber; H. Nakauchi Endomucin, a CD34-like sialomucin, marks hematopoietic stem cells throughout development Journal of Experimental Medicine,202,11,1483-1492 2005 Refereed English
J. Kitaura; K. Eto; T. Kinoshita; Y. Kawakami; M. Leitges; C.A. Lowell; T. Kawakami Regulation of highly cytokinergic IgE-induced mast cell adhesion by Src, Syk, Tec, and protein kinase C family kinases Journal of Immunology,174,8,4495-4504 2005 Refereed English
S. Tadokoro; S.J. Shattil; K. Eto; V. Tai; R.C. Liddington; J.M. De Pereda; M.H. Ginsberg; D.A. Calderwood Talin binding to integrin β tails: A final common step in integrin activation Science,302,5642,103-106 2003 Refereed English
K. Eto; A.L. Leavitt; T. Nakano; S.J. Shattil Development and Analysis of Megakaryocytes from Murine Embryonic Stem Cells Methods in Enzymology,365,142-158 2003 Refereed English
M. Sakakibara; S. Goto; K. Eto; N. Tamura; T. Isshiki; S. Handa Application of ex vivo flow chamber system for assessment of stent thrombosis Arteriosclerosis, Thrombosis, and Vascular Biology,22,8,1360-1364 2002 Refereed English
T. Yamauchi; J. Kamon; Y. Minokoshi; Y. Ito; H. Waki; S. Uchida; S. Yamashita; M. Noda; S. Kita; K. Ueki; K. Eto; Y. Akanuma; P. Froguel; F. Foufelle; P. Ferre; D. Carling; S. Kimura; R. Nagai; B.B. Kahn; T. Kadowaki Adiponectin stimulates glucose utilization and fatty-acid oxidation by activating AMP-activated protein kinase Nature Medicine,8,11,1288-1295 2002 Refereed English
A. Bertoni; S. Tadokoro; K. Eto; N. Pampori; L.V. Parise; G.C. White; S.J. Shattil Relationships between Rap1b, affinity modulation of integrin α<sub>IIb</sub>β<sub>3</sub> and the actin cytoskeleton Journal of Biological Chemistry,277,28,25715-25721 2002 Refereed English
A. Obergfell; K. Eto; A. Mocsai; C. Buensuceso; S.L. Moores; J.S. Brugge; C.A. Lowell; S.J. Shattil Coordinate interactions of Csk, Src, and Syk kinases with αIIbβ3 initiate integrin signaling to the cytoskeleton Journal of Cell Biology,157,2,265-275 2002 Refereed English
K. Eto; C. Huet; T. Tarui; S. Kupriyanov; H.-Z. Liu; W. Puzon-McLaughlin; X.-P. Zhang; D. Sheppard; E. Engvall; Y. Takada Functional classification of ADAMs based on a conserved motif for binding to integrin α<sub>9</sub>β<sub>1</sub>. Implications for sperm-egg binding and other cell interactions Journal of Biological Chemistry,277,20,17804-17810 2002 Refereed English
S. Goto; N. Tamura; K. Eto; Y. Ikeda; S. Handa Functional significance of adenosine 5′-diphosphate receptor (P2Y<sub>12</sub>) in platelet activation initiated by binding of von Willebrand factor to platelet GP Ibα induced by conditions of high shear rate Circulation,105,21,2531-2536 2002 Refereed English
K. Eto; S. Goto; T. Shimazaki; M. Sakakibara; M. Yoshida; T. Isshiki; S. Handa Two distinct mechanisms are involved in stent thrombosis under flow conditions Platelets,12,4,228-235 2001 Refereed English
K. Eto; M. Ochiai; T. Isshiki; S. Takeshita; M. Terakura; T. Sato; Y. Ikeda; S. Handa; S. Goto Platelet aggregability under shear is enhanced in patients with unstable angina pectoris who developed acute myocardial infarction Japanese Circulation Journal,65,4,279-282 2001 Refereed English
M. Ochiai; Y. Ikari; T. Yamaguchi; T. Isshiki; Y. Koyama; K. Eto; S. Takeshita; T. Tamura; T. Sato New long-tip guiding catheters designed for right transradial coronary intervention Catheterization and Cardiovascular Interventions,49,2,218-224 2000 Refereed English
A. Oshima; M. Ochiai; S. Takeshita; N. Yokoyama; H. Mitani; K. Eto; T. Isshiki; T. Sato Serial automated three-dimensional intravascular ultrasound analysis of the self-expanding radius stent American Journal of Cardiology,85,3,401-402 2000 Refereed English
A. Oshima; M. Ochiai; S. Takeshita; N. Yokoyama; H. Mitani; K. Eto; T. Isshiki; T. Sato Serial automated three-dimensional intravascular ultrasound analysis of the self-expanding radius stent American Journal of Cardiology,85,3,388-391 2000 Refereed English
K. Eto; W. Puzon-McLaughlin; D. Sheppard; A. Sehara-Fujisawa; X.-P. Zhang; Y. Takada RGD-independent binding of integrin α<sub>9</sub>β<sub>1</sub> to the ADAM-12 and -15 disintegrin domains mediates cell-cell interaction Journal of Biological Chemistry,275,45,34922-34930 2000 Refereed English
T. Shimazaki; S. Goto; M. Sakakibara; K. Eto; J.-Y. Kim; N. Ichikawa; M. Yoshida; Y. Nagaoka; T. Isshiki; S. Handa Different inhibiting effects of abciximab and tirofiban on platelet thrombus formation on a collagen surface under flow conditions Journal of Cardiology,36,2,113-121 2000 Refereed English
M. Ochiai; K. Eto; S. Takeshita; N. Yokoyama; A. Oshima; K. Kondo; T. Sato; T. Isshiki Impact of cilostazol on clinical and angiographic outcome after primary stenting for acute myocardial infarction American Journal of Cardiology,84,9,1074-1076 1999 Refereed English
M. Ochiai; T. Isshiki; H. Toyoizumi; K. Eto; N. Yokoyama; Y. Koyama; S. Takeshita; T. Sato Efficacy of transradial primary stenting in patients with acute myocardial infarction American Journal of Cardiology,83,6,966-968 1999 Refereed English
S. Goto; K. Eto; Y. Ikeda; S. Handa Abciximab not RGD peptide inhibits von Willebrand factor-dependent platelet activation under shear Lancet,353,9155,809- 1999 Refereed English
K. Eto; K. Hashimoto; H. Nakaya Preferential inhibition of by MCI-154, a putative cardiotonic Ca<sup>2+</sup> sensitizer, in guinea pig atrial cells Cardiovascular Research,38,3,685-694 1998 Refereed English
K. Eto; S. Takeshita; M. Ochiai; Y. Ozaki; T. Sato; T. Isshiki Platelet aggregation in acute coronary syndromes: Use of a new aggregometer with laser light scattering to assess platelet aggregability Cardiovascular Research,40,1,223-229 1998 Refereed English
M. Ochiai; T. Isshiki; K. Eto; N. Yokoyama; T. Fusano; S. Takeshita; T. Sato Significance of development of late potentials after anterior wall acute myocardial infarction despite successful primary angioplasty of the left anterior descending coronary artery American Journal of Cardiology,81,10,1239-1241 1998 Refereed English
S. Takeshita; T. Isshiki; M. Ochiai; K. Eto; H. Mori; E. Tanaka; K. Umetani; T. Sato Endothelium-dependent relaxation of collateral microvessels after intramuscular gene transfer of vascular endothelial growth factor in a rat model of hindlimb ischemia Circulation,98,13,1261-1263 1998 Refereed English
S. Takeshita; T. Isshiki; H. Mori; E. Tanaka; A. Tanaka; K. Umetani; K. Eto; Y. Miyazawa; M. Ochiai; Tomohide Sato Microangiographic assessment of collateral vessel formation following direct gene transfer of vascular endothelial growth factor in rats Cardiovascular Research,35,3,547-552 1997 Refereed English
M. Kanda; K. Eto; N. Tanabe; A. Sugiyama; K. Hashimoto; A. Ueno Effects of ONO-2235, an aldose reductase inhibitor, on muscarinic receptors and contractile response of the urinary bladder in rats with streptozotocin-induced diabetes Japanese Journal of Pharmacology,73,3,221-228 1997 Refereed English
M. Ochiai; T. Isshiki; S. Takeshita; K. Eto; H. Toyoizumi; T. Sato; H. Miyashita Use of cilostazol, a novel antiplatelet agent, in a post-Palmaz-Schatz stenting regimen American Journal of Cardiology,79,11,1471-1474 1997 Refereed English
S. Takeshita; T. Isshiki; H. Mori; E. Tanaka; K. Eto; Y. Miyazawa; A. Tanaka; Y. Shinozaki; K. Hyodo; M. Ando; M. Kubota; K. Tanioka; K. Umetani; M. Ochiai; T. Sato; H. Miyashita Use of synchrotron radiation microangiography to assess development of small collateral arteries in a rat model of hindlimb ischemia Circulation,95,4,805-808 1997 Refereed English
J. Chen; Y. Xue; K. Eto; C. Ni; K. Hashimoto Effects of dofetilide, a class III antiarrhythmic drug, on various ventricular arrhythmias in dogs Journal of Cardiovascular Pharmacology,28,4,576-584 1996 Refereed English
M. Nakamura; Y. Xue; K. Eto; K. Hashimoto Antiarrhythmic effects of optical isomers of disopyramide on canine ventricular arrhythmias Journal of Cardiovascular Pharmacology,27,3,368-375 1996 Refereed English
Y.X. Xue; K. Eto; Y. Akie; K. Hashimoto Antiarrhythmic and proarrhythmic effects of sematilide in canine ventricular arrhythmia models Japanese Journal of Pharmacology,70,2,129-138 1996 Refereed English
K. Eto; Y.X. Xue; K. Hashimoto Effects of MCI-154, a new cardiotonic Ca<sup>2+</sup> sensitizer, on ventricular arrhythmias and membrane ionic currents European Journal of Pharmacology,298,3,247-256 1996 Refereed English
A. Sugiyama; C. Ni; J. Arita; K. Eto; Y.-X. Xue; K. Hashimoto Effects of the antihypoxic and neuroprotective drug, lubeluzole, on repolarization phase of canine heart assessed by monophasic action potential recording Toxicology and Applied Pharmacology,139,1,109-114 1996 Refereed English
K. Ono; K. Eto; A. Sakamoto; T. Masaki; K. Shibata; T. Sada; K. Hashimoto; G. Tsujimoto Negative chronotropic effect of endothelin 1 mediated through ET<sub>A</sub> receptors in guinea pig atria Circulation Research,76,2,284-292 1995 Refereed English
K. Ono; G. Tsujlmoto; A. Sakamoto; K. Eto; T. Masaki; Y. Ozaki; M. Satake Endothelin-A receptor mediates cardiac inhibition by regulating calcium and potassium currents Nature,370,6487,301-304 1994 Refereed English

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Published Papers > International Society
(文系研究者の一般的な論文集への寄稿や単行本の分担執筆などは「著書等」を参照してください)
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Published Papers > Domestic Society
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Published Papers > Other
(文系研究者の一般的な論文集への寄稿や単行本の分担執筆などは「著書等」を参照してください)
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Conference Presentation > Conference Presentation
(文系研究者の一般的な学会報告の業績は「講演等」を参照してください)
Authors Title Bibliography Date Peer-Review Language
Eto K*, Isshiki T, Yamamoto H, Takeshita S, Ochiai M, Yokoyama N, Yoshimoto R, Ikeda Y, Sato T AJvW-2, an anti-vWF monoclonal antibody, inhibits enhanced platelet aggregation induced by high shear stress in platelet rich plasma from patients with acute coronary syndromes. Arteriosclerosis, Thrombosis, and Vascular Biology,19,877-882 1999
M. Kajiwara; T. Aoi; K. Okita; R. Takahashi; H. Inoue; N. Takayama; H. Endo; K. Eto; J. Toguchida; S. Uemoto; S. Yamanaka Donor-dependent variations in hepatic differentiation from human-induced pluripotent stem cells Proceedings of the National Academy of Sciences of the United States of America,109,31,12538-12543 2012/07/31 Refereed English
Y. Nakagawa; S. Ikeda; T. Fukuda; F. Arai; S. Nakamura; K. Eto Production system of platelet from iPS cells by two-way flow bioreactor 2012 International Symposium on Micro-NanoMechatronics and Human Science, MHS 2012,178-181 2012 Refereed English
J. Seita; H. Ema; J. Ooehara; S. Yamazaki; Y. Tadokoro; A. Yamasaki; K. Eto; S. Takaki; K. Takatsu; H. Nakauchi Lnk negatively regulates self-renewal of hematopoietic stem cells by modifying thrombopoietin-mediated signal transduction Proceedings of the National Academy of Sciences of the United States of America,104,7,2349-2354 2007 Refereed English
Koji Eto Embryonic stem cell-derived platelets having the potential of normal hemostasis International Symposium on “Germ Cells, Epigenetics, Reprogramming and Embryonic Stem Cells” November 15-18, 2005 at Kyoto University 2005 Refereed English
K. Eto; R. Murphy; S.W. Kerrigan; A. Bertoni; H. Stuhlmann; T. Nakano; A.D. Leavitt; S.J. Shattil Megakaryocytes derived from embryonic stem cells implicate CalDAG-GEFI in integrin signaling Proceedings of the National Academy of Sciences of the United States of America,99,20,12819-12824 2002 Refereed English

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Conference Presentation > International Society
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Conference Presentation > Domestic Society
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Conference Presentation > Other
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Lectures > Invited Lectures
(文系研究者の一般的な学会報告はこの項に収録されております)
Title Conference name Organization name Date Language

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Lectures > Keynote Lectures
(文系研究者の一般的な学会報告はこの項に収録されております)
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Lectures > Panels
(文系研究者の一般的な学会報告はこの項に収録されております)
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Lectures > Public Talks
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Publications > Books
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Publications > Translations
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Publications > Other
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Patents
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External funds, competitive funds and Grants-in-Aid for Scientific Research(kaken)
Type Position Title(Japanese) Title(English) Period
基盤研究(B) Representative エピゲノムプログラム変換3D環境システムの開発                  2012-2014
基盤研究(B) Representative エピゲノムプログラム変換3D環境システムの開発 (平成26年度分) 2014/04/01-2015/03/31