上杉志成

Last Update: 2020/07/16 10:39:50

Name(Kanji/Kana/Abecedarium Latinum)

上杉志成/ウエスギモトナリ/Uesugi, Motonari

Primary Affiliation(Org1/Job title)

Institute for Chemical Research (ICR)/Professor

Concurrent Affiliation

Org1	Job title
物質－細胞統合システム拠点	連携ＰＩ

Contact Address

Type	Address(Japanese)	Address(English)
Office	〒611-0011　京都府宇治市五ヶ庄	Gokasho, Uji, Kyoto 6110011, Japan

Phone

Type	Number
Office	0774-38-3225

Academic Degree

Field(Japanese)	Field(English)	University(Japanese)	University(English)	Method
修士（薬学）	M.S.	京都大学	Kyoto University
博士（薬学）	Ph.D	京都大学	Kyoto University

Language of Instruction

Language(japanese)	Language(english)	Code
日本語	Japanese	jpn
英語	English	eng
Korean (intermediate)

Personal Website(s) (URL(s))

URL
https://www.scl.kyoto-u.ac.jp/~uesugi/ja/index.php

ORCID ID

https://orcid.org/0000-0002-8515-445X

researchmap URL

https://researchmap.jp/read0122106

Research Topics

(Japanese)
ケミカルバイオロジー
(English)
Chemical Biology

Overview of the research

(Japanese)
ケミカルバイオロジーとは、化学を起点とした生物学です。生命の営みはせんじつめれば化学反応でできています。逆に化学を使って生命現象を理解したり、操ることができるはず。私たちの研究室では、生き物やヒト細胞にユニークな効果を及ぼす独自な有機化合物を見つける、もしくはデザインし、それらを道具として生命現象を探究・操作してきました。生物の仕組みは複雑ですが、有機化合物を起爆剤として用いることで、新たな切り口で生物を研究したり操作することができます。私たちの大きな研究目標は、生理活性合成化合物の新しい世界を切り開くことです。生理活性化合物の新しい利用法、新しいカタチをした生理活性化合物、新しいサイズの生理活性化合物など、アイデアを与えることができればと思うのです。こういったアイデアは、未来の創薬の考え方や化合物の細胞治療への利用などに結びつくはずです。
(English)
Chemical biology is an interdisciplinary field of study that is often defined as "chemistry-initiated biology." As biological processes all stem from chemical events, it should be possible to understand or manipulate biological events by using chemistry. Our laboratory has been discovering or designing unique organic molecules that modulate fundamental processes in human cells. Such synthetic organic molecules often serve as tools for basic cell biology. Discovery or design of small molecules with unique biological activity permits small-molecule initiated exploration of complex cellular events. Our mission is to create new world of bioactive synthetic molecules: their new way to use, their new shapes, and their new sizes. We hope to open new avenues for small-molecule applications in a range of fields, including future concepts in drug discovery and use of small molecules for cell therapy.

Fields of research (key words)

Key words(Japanese)	Key words(English)
ケミカルバイオロジー	Chemical Biology
生理活性小分子	Bioactive Small Molecules
化学プローブ	Chemical Probes
細胞治療	Cell Therapy
自己集合	Self-Assembly
化合物ライブラリー	Compound Library

Published Papers

Author	Author(Japanese)	Author(English)	Title	Title(Japanese)	Title(English)	Bibliography	Bibliography(Japanese)	Bibliography(English)	Publication date	Refereed paper	Language	Publishing type	Disclose
Louvy Lynn Punzalan, Lulu Jiang, Di Mao, Amarjyoti Das Mahapatra, Shinichi Sato, Yasushi Takemoto, Mari Tsujimura, Kosuke Kusamori, Makiya Nishikawa, Lu Zhou, Motonari Uesugi	Louvy Lynn Punzalan, Lulu Jiang, Di Mao, Amarjyoti Das Mahapatra, Shinichi Sato, Yasushi Takemoto, Mari Tsujimura, Kosuke Kusamori, Makiya Nishikawa, Lu Zhou, Motonari Uesugi	Louvy Lynn Punzalan, Lulu Jiang, Di Mao, Amarjyoti Das Mahapatra, Shinichi Sato, Yasushi Takemoto, Mari Tsujimura, Kosuke Kusamori, Makiya Nishikawa, Lu Zhou, Motonari Uesugi	Chemoproteomic Profiling of a Pharmacophore-Focused Chemical Library.	Chemoproteomic Profiling of a Pharmacophore-Focused Chemical Library.	Chemoproteomic Profiling of a Pharmacophore-Focused Chemical Library.	Cell chemical biology	Cell chemical biology	Cell chemical biology	2020/04/28	Refereed	English	Research paper(scientific journal)	Disclose to all
Yasushi Takemoto, Di Mao, Louvy Lynn Punzalan, Sebastian Götze, Shin-Ichi Sato, Motonari Uesugi	Yasushi Takemoto, Di Mao, Louvy Lynn Punzalan, Sebastian Götze, Shin-Ichi Sato, Motonari Uesugi	Yasushi Takemoto, Di Mao, Louvy Lynn Punzalan, Sebastian Götze, Shin-Ichi Sato, Motonari Uesugi	Discovery of a Small-Molecule-Dependent Photolytic Peptide.	Discovery of a Small-Molecule-Dependent Photolytic Peptide.	Discovery of a Small-Molecule-Dependent Photolytic Peptide.	Journal of the American Chemical Society, 142, 3, 1142-1146	Journal of the American Chemical Society, 142, 3, 1142-1146	Journal of the American Chemical Society, 142, 3, 1142-1146	2020/01/22	Refereed	English		Disclose to all
Akiko Nagata, Yusuke Akagi, Lisa Asano, Kenjiro Kotake, Fumihiro Kawagoe, Aileen Mendoza, Shadi Sedghi Masoud, Kosuke Usuda, Koji Yasui, Yasushi Takemoto, Atsushi Kittaka, Kazuo Nagasawa, Motonari Uesugi	Nagata A, Akagi Y, Asano L, Kotake K, Kawagoe F, Mendoza A, Masoud SS, Usuda K, Yasui K, Takemoto Y, Kittaka A, Nagasawa K, Uesugi M	Akiko Nagata, Yusuke Akagi, Lisa Asano, Kenjiro Kotake, Fumihiro Kawagoe, Aileen Mendoza, Shadi Sedghi Masoud, Kosuke Usuda, Koji Yasui, Yasushi Takemoto, Atsushi Kittaka, Kazuo Nagasawa, Motonari Uesugi	Synthetic Chemical Probes That Dissect Vitamin D Activities.	Synthetic Chemical Probes That Dissect Vitamin D Activities.	Synthetic Chemical Probes That Dissect Vitamin D Activities.	ACS chemical biology, 14, 12, 2851-2858	ACS chemical biology, 14, 12, 2851-2858	ACS chemical biology, 14, 12, 2851-2858	2019/12/20	Refereed	English		Disclose to all
Furuta T, Mizukami Y, Asano L, Kotake K, Ziegler S, Yoshida H, Watanabe M, Sato SI, Waldmann H, Nishikawa M, Uesugi M	Furuta T, Mizukami Y, Asano L, Kotake K, Ziegler S, Yoshida H, Watanabe M, Sato SI, Waldmann H, Nishikawa M, Uesugi M	Furuta T, Mizukami Y, Asano L, Kotake K, Ziegler S, Yoshida H, Watanabe M, Sato SI, Waldmann H, Nishikawa M, Uesugi M	Nutrient-Based Chemical Library as a Source of Energy Metabolism Modulators.	Nutrient-Based Chemical Library as a Source of Energy Metabolism Modulators.	Nutrient-Based Chemical Library as a Source of Energy Metabolism Modulators.	ACS chemical biology, 14, 9, 1860-1865	ACS chemical biology, 14, 9, 1860-1865	ACS chemical biology, 14, 9, 1860-1865	2019/09	Refereed			Disclose to all
Ippei Takashima, Kosuke Kusamori, Hayase Hakariya, Megumi Takashima, Thi Hue Vu, Yuya Mizukami, Naotaka Noda, Yukiya Takayama, Yousuke Katsuda, Shin-ichi Sato, Yoshinobu Takakura, Makiya Nishikawa, Motonari Uesugi	Ippei Takashima, Kosuke Kusamori, Hayase Hakariya, Megumi Takashima, Thi Hue Vu, Yuya Mizukami, Naotaka Noda, Yukiya Takayama, Yousuke Katsuda, Shin-ichi Sato, Yoshinobu Takakura, Makiya Nishikawa, Motonari Uesugi	Ippei Takashima, Kosuke Kusamori, Hayase Hakariya, Megumi Takashima, Thi Hue Vu, Yuya Mizukami, Naotaka Noda, Yukiya Takayama, Yousuke Katsuda, Shin-ichi Sato, Yoshinobu Takakura, Makiya Nishikawa, Motonari Uesugi	Multifunctionalization of Cells with a Self-Assembling Molecule to Enhance Cell Engraftment	Multifunctionalization of Cells with a Self-Assembling Molecule to Enhance Cell Engraftment	Multifunctionalization of Cells with a Self-Assembling Molecule to Enhance Cell Engraftment	ACS Chemical Biology, 14, 4, 775-783	ACS Chemical Biology, 14, 4, 775-783	ACS Chemical Biology, 14, 4, 775-783	2019/04/19	Refereed		Research paper(scientific journal)	Disclose to all
Mao D, Chung XKW, Andoh-Noda T, Qin Y, Sato SI, Takemoto Y, Akamatsu W, Okano H, Uesugi M	Mao D, Chung XKW, Andoh-Noda T, Qin Y, Sato SI, Takemoto Y, Akamatsu W, Okano H, Uesugi M	Mao D, Chung XKW, Andoh-Noda T, Qin Y, Sato SI, Takemoto Y, Akamatsu W, Okano H, Uesugi M	Chemical decontamination of iPS cell-derived neural cell mixtures.	Chemical decontamination of iPS cell-derived neural cell mixtures.	Chemical decontamination of iPS cell-derived neural cell mixtures.	Chemical communications (Cambridge, England), 54, 11, 1355-1358	Chemical communications (Cambridge, England), 54, 11, 1355-1358	Chemical communications (Cambridge, England), 54, 11, 1355-1358	2018/02	Refereed			Disclose to all
Kenji Yatsuzuka, Shin-ichi Sato, Kathleen Beverly Pe, Yousuke Katsuda, Ippei Takashima, Mizuki Watanabe, Motonari Uesugi	Kenji Yatsuzuka, Shin-ichi Sato, Kathleen Beverly Pe, Yousuke Katsuda, Ippei Takashima, Mizuki Watanabe, Motonari Uesugi	Kenji Yatsuzuka, Shin-ichi Sato, Kathleen Beverly Pe, Yousuke Katsuda, Ippei Takashima, Mizuki Watanabe, Motonari Uesugi	Live-cell imaging of multiple endogenous mRNAs permits the direct observation of RNA granule dynamics	Live-cell imaging of multiple endogenous mRNAs permits the direct observation of RNA granule dynamics	Live-cell imaging of multiple endogenous mRNAs permits the direct observation of RNA granule dynamics	Chemical Communications, 54, 52, 7151-7154	Chemical Communications, 54, 52, 7151-7154	Chemical Communications, 54, 52, 7151-7154	2018	Refereed		Research paper(scientific journal)	Disclose to all
Shin-ichi Sato, Kenji Yatsuzuka, Yousuke Katsuda, Motonari Uesugi	Shin-ichi Sato, Kenji Yatsuzuka, Yousuke Katsuda, Motonari Uesugi	Shin-ichi Sato, Kenji Yatsuzuka, Yousuke Katsuda, Motonari Uesugi	Method for Imaging Live-Cell RNA Using an RNA Aptamer and a Fluorescent Probe	Method for Imaging Live-Cell RNA Using an RNA Aptamer and a Fluorescent Probe	Method for Imaging Live-Cell RNA Using an RNA Aptamer and a Fluorescent Probe	Methods in Molecular Biology, 1649, 305-318	Methods in Molecular Biology, 1649, 305-318	Methods in Molecular Biology, 1649, 305-318	2018	Refereed			Disclose to all
Amelie Perron, Yoshihiro Nishikawa, Jun Iwata, Hiromi Shimojo, Junichiro Takaya, Kumiko Kobayashi, Itaru Imayoshi, Naasson M. Mbenza, Mihoko Takenoya, Ryoichiro Kageyama, Yuzo Kodama, Motonari Uesugi	Amelie Perron, Yoshihiro Nishikawa, Jun Iwata, Hiromi Shimojo, Junichiro Takaya, Kumiko Kobayashi, Itaru Imayoshi, Naasson M. Mbenza, Mihoko Takenoya, Ryoichiro Kageyama, Yuzo Kodama, Motonari Uesugi	Amelie Perron, Yoshihiro Nishikawa, Jun Iwata, Hiromi Shimojo, Junichiro Takaya, Kumiko Kobayashi, Itaru Imayoshi, Naasson M. Mbenza, Mihoko Takenoya, Ryoichiro Kageyama, Yuzo Kodama, Motonari Uesugi	Small-molecule screening yields a compound that inhibits the cancer-associated transcription factor Hes1 via the PHB2 chaperone	Small-molecule screening yields a compound that inhibits the cancer-associated transcription factor Hes1 via the PHB2 chaperone	Small-molecule screening yields a compound that inhibits the cancer-associated transcription factor Hes1 via the PHB2 chaperone	Journal of Biological Chemistry, 293, 21, 8285-8294	Journal of Biological Chemistry, 293, 21, 8285-8294	Journal of Biological Chemistry, 293, 21, 8285-8294	2018	Refereed			Disclose to all
Asano L, Watanabe M, Ryoden Y, Usuda K, Yamaguchi T, Khambu B, Takashima M, Sato SI, Sakai J, Nagasawa K, Uesugi M	Asano L, Watanabe M, Ryoden Y, Usuda K, Yamaguchi T, Khambu B, Takashima M, Sato SI, Sakai J, Nagasawa K, Uesugi M	Asano L, Watanabe M, Ryoden Y, Usuda K, Yamaguchi T, Khambu B, Takashima M, Sato SI, Sakai J, Nagasawa K, Uesugi M	Vitamin D Metabolite, 25-Hydroxyvitamin D, Regulates Lipid Metabolism by Inducing Degradation of SREBP/SCAP.	Vitamin D Metabolite, 25-Hydroxyvitamin D, Regulates Lipid Metabolism by Inducing Degradation of SREBP/SCAP.	Vitamin D Metabolite, 25-Hydroxyvitamin D, Regulates Lipid Metabolism by Inducing Degradation of SREBP/SCAP.	Cell chemical biology, 24, 2, 207-217	Cell Chemical Biology, 24, 2, 207-217	Cell chemical biology, 24, 2, 207-217	2017/02	Refereed			Disclose to all
Di Mao, Shin Ando, Shin-ichi Sato, Ying Qin, Nao Hirata, Yousuke Katsuda, Eihachiro Kawase, Ting-Fang Kuo, Itsunari Minami, Yuji Shiba, Kazumitsu Ueda, Norio Nakatsuji, Motonari Uesugi	Di Mao, Shin Ando, Shin-ichi Sato, Ying Qin, Nao Hirata, Yousuke Katsuda, Eihachiro Kawase, Ting-Fang Kuo, Itsunari Minami, Yuji Shiba, Kazumitsu Ueda, Norio Nakatsuji, Motonari Uesugi	Di Mao, Shin Ando, Shin-ichi Sato, Ying Qin, Nao Hirata, Yousuke Katsuda, Eihachiro Kawase, Ting-Fang Kuo, Itsunari Minami, Yuji Shiba, Kazumitsu Ueda, Norio Nakatsuji, Motonari Uesugi	A Synthetic Hybrid Molecule for the Selective Removal of Human Pluripotent Stem Cells from Cell Mixtures	A Synthetic Hybrid Molecule for the Selective Removal of Human Pluripotent Stem Cells from Cell Mixtures	A Synthetic Hybrid Molecule for the Selective Removal of Human Pluripotent Stem Cells from Cell Mixtures	ANGEWANDTE CHEMIE-INTERNATIONAL EDITION, 56, 7, 1765-1770	ANGEWANDTE CHEMIE-INTERNATIONAL EDITION, 56, 7, 1765-1770	ANGEWANDTE CHEMIE-INTERNATIONAL EDITION, 56, 7, 1765-1770	2017/02	Refereed	English	Research paper(scientific journal)	Disclose to all
Lisa Asano, Mizuki Watanabe, Yuta Ryoden, Kousuke Usuda, Takuya Yamaguchi, Bilon Khambu, Megumi Takashima, Shin-ichi Sato, Juro Sakai, Kazuo Nagasawa, Motonari Uesugi	Lisa Asano, Mizuki Watanabe, Yuta Ryoden, Kousuke Usuda, Takuya Yamaguchi, Bilon Khambu, Megumi Takashima, Shin-ichi Sato, Juro Sakai, Kazuo Nagasawa, Motonari Uesugi	Lisa Asano, Mizuki Watanabe, Yuta Ryoden, Kousuke Usuda, Takuya Yamaguchi, Bilon Khambu, Megumi Takashima, Shin-ichi Sato, Juro Sakai, Kazuo Nagasawa, Motonari Uesugi	Vitamin D Metabolite, 25-Hydroxyvitamin D, Regulates Lipid Metabolism by Inducing Degradation of SREBP/SCAP	Vitamin D Metabolite, 25-Hydroxyvitamin D, Regulates Lipid Metabolism by Inducing Degradation of SREBP/SCAP	Vitamin D Metabolite, 25-Hydroxyvitamin D, Regulates Lipid Metabolism by Inducing Degradation of SREBP/SCAP	CELL CHEMICAL BIOLOGY, 24, 2, 207-217	CELL CHEMICAL BIOLOGY, 24, 2, 207-217	CELL CHEMICAL BIOLOGY, 24, 2, 207-217	2017/02	Refereed	English	Research paper(scientific journal)	Disclose to all
Yusuke Akagi, Kosuke Usuda, Tomoe Tanami, Koji Yasui, Lisa Asano, Motonari Uesugi, Kazuo Nagasawa	Yusuke Akagi, Kosuke Usuda, Tomoe Tanami, Koji Yasui, Lisa Asano, Motonari Uesugi, Kazuo Nagasawa	Yusuke Akagi, Kosuke Usuda, Tomoe Tanami, Koji Yasui, Lisa Asano, Motonari Uesugi, Kazuo Nagasawa	Synthesis of 1 alpha- and 1 beta-amino-25-hydroxyvitamin D-3	Synthesis of 1 alpha- and 1 beta-amino-25-hydroxyvitamin D-3	Synthesis of 1 alpha- and 1 beta-amino-25-hydroxyvitamin D-3	ASIAN JOURNAL OF ORGANIC CHEMISTRY, 5, 10, 1247-1252	ASIAN JOURNAL OF ORGANIC CHEMISTRY, 5, 10, 1247-1252	ASIAN JOURNAL OF ORGANIC CHEMISTRY, 5, 10, 1247-1252	2016/10	Refereed	English	Research paper(scientific journal)	Disclose to all
Yousuke Katsuda, Shin-ichi Sato, Lisa Asano, Yoshitaka Morimura, Tomoyuki Furuta, Hiroshi Sugiyama, Masaki Hagihara, Motonari Uesugi	Yousuke Katsuda, Shin-ichi Sato, Lisa Asano, Yoshitaka Morimura, Tomoyuki Furuta, Hiroshi Sugiyama, Masaki Hagihara, Motonari Uesugi	Yousuke Katsuda, Shin-ichi Sato, Lisa Asano, Yoshitaka Morimura, Tomoyuki Furuta, Hiroshi Sugiyama, Masaki Hagihara, Motonari Uesugi	A Small Molecule That Represses Translation of G-Quadruplex-Containing mRNA	A Small Molecule That Represses Translation of G-Quadruplex-Containing mRNA	A Small Molecule That Represses Translation of G-Quadruplex-Containing mRNA	JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 138, 29, 9037-9040	JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 138, 29, 9037-9040	JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 138, 29, 9037-9040	2016/07	Refereed	English	Research paper(scientific journal)	Disclose to all
Junichiro Takaya, Kazuhiro Mio, Takuya Shiraishi, Tatsuki Kurokawa, Shinya Otsuka, Yasuo Mori, Motonari Uesugi	Junichiro Takaya, Kazuhiro Mio, Takuya Shiraishi, Tatsuki Kurokawa, Shinya Otsuka, Yasuo Mori, Motonari Uesugi	Junichiro Takaya, Kazuhiro Mio, Takuya Shiraishi, Tatsuki Kurokawa, Shinya Otsuka, Yasuo Mori, Motonari Uesugi	A Potent and Site-Selective Agonist of TRPA1	A Potent and Site-Selective Agonist of TRPA1	A Potent and Site-Selective Agonist of TRPA1	JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 137, 50, 15859-15864	JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 137, 50, 15859-15864	JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 137, 50, 15859-15864	2015/12	Refereed	English	Research paper(scientific journal)	Disclose to all
S. Sato, M. Watanabe, Y. Katsuda, A. Murata, D.O. Wang, M. Uesugi	S. Sato, M. Watanabe, Y. Katsuda, A. Murata, D.O. Wang, M. Uesugi	S. Sato, M. Watanabe, Y. Katsuda, A. Murata, D.O. Wang, M. Uesugi	Live-cell Imaging of Endogenous mRNAs with a Small Molecule	Live-cell Imaging of Endogenous mRNAs with a Small Molecule	Live-cell Imaging of Endogenous mRNAs with a Small Molecule	Angewandte Chemie International Edition in English, 127, 1875-1878	Angewandte Chemie International Edition in English, 127, 1875-1878	Angewandte Chemie International Edition in English, 127, 1875-1878	2015/02	Refereed	English		Disclose to all
Shin-ichi Sato, Mizuki Watanabe, Yousuke Katsuda, Asako Murata, Dan Ohtan Wang, Motonari Uesugi	Shin-ichi Sato, Mizuki Watanabe, Yousuke Katsuda, Asako Murata, Dan Ohtan Wang, Motonari Uesugi	Shin-ichi Sato, Mizuki Watanabe, Yousuke Katsuda, Asako Murata, Dan Ohtan Wang, Motonari Uesugi	Live-Cell Imaging of Endogenous mRNAs with a Small Molecule	Live-Cell Imaging of Endogenous mRNAs with a Small Molecule	Live-Cell Imaging of Endogenous mRNAs with a Small Molecule	ANGEWANDTE CHEMIE-INTERNATIONAL EDITION, 54, 6, 1855-1858	ANGEWANDTE CHEMIE-INTERNATIONAL EDITION, 54, 6, 1855-1858	ANGEWANDTE CHEMIE-INTERNATIONAL EDITION, 54, 6, 1855-1858	2015/02	Refereed	English	Research paper(scientific journal)	Disclose to all
Heidie L. Frisco-Cabanos, Mizuki Watanabe, Naoki Okumura, Kosuke Kusamori, Naohiro Takemoto, Junichiro Takaya, Shin-ichi Sato, Sayumi Yamazoe, Yoshinobu Takakura, Shigeru Kinoshita, Makiya Nishikawa, Noriko Koizumi, Motonari Uesugi	Heidie L. Frisco-Cabanos, Mizuki Watanabe, Naoki Okumura, Kosuke Kusamori, Naohiro Takemoto, Junichiro Takaya, Shin-ichi Sato, Sayumi Yamazoe, Yoshinobu Takakura, Shigeru Kinoshita, Makiya Nishikawa, Noriko Koizumi, Motonari Uesugi	Heidie L. Frisco-Cabanos, Mizuki Watanabe, Naoki Okumura, Kosuke Kusamori, Naohiro Takemoto, Junichiro Takaya, Shin-ichi Sato, Sayumi Yamazoe, Yoshinobu Takakura, Shigeru Kinoshita, Makiya Nishikawa, Noriko Koizumi, Motonari Uesugi	Synthetic Molecules that Protect Cells from Anoikis and Their Use in Cell Transplantation	Synthetic Molecules that Protect Cells from Anoikis and Their Use in Cell Transplantation	Synthetic Molecules that Protect Cells from Anoikis and Their Use in Cell Transplantation	ANGEWANDTE CHEMIE-INTERNATIONAL EDITION, 53, 42, 11208-11213	ANGEWANDTE CHEMIE-INTERNATIONAL EDITION, 53, 42, 11208-11213	ANGEWANDTE CHEMIE-INTERNATIONAL EDITION, 53, 42, 11208-11213	2014/10	Refereed	English	Research paper(scientific journal)	Disclose to all
Ting-Fang Kuo, Di Mao, Nao Hirata, Bilon Khambu, Yasuhisa Kimura, Eihachiro Kawase, Hiroki Shimogawa, Makoto Ojika, Norio Nakatsuji, Kazumitsu Ueda, Motonari Uesugi	Ting-Fang Kuo, Di Mao, Nao Hirata, Bilon Khambu, Yasuhisa Kimura, Eihachiro Kawase, Hiroki Shimogawa, Makoto Ojika, Norio Nakatsuji, Kazumitsu Ueda, Motonari Uesugi	Ting-Fang Kuo, Di Mao, Nao Hirata, Bilon Khambu, Yasuhisa Kimura, Eihachiro Kawase, Hiroki Shimogawa, Makoto Ojika, Norio Nakatsuji, Kazumitsu Ueda, Motonari Uesugi	Selective Elimination of Human Pluripotent Stem Cells by a Marine Natural Product Derivative	Selective Elimination of Human Pluripotent Stem Cells by a Marine Natural Product Derivative	Selective Elimination of Human Pluripotent Stem Cells by a Marine Natural Product Derivative	JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 136, 28, 9798-9801	JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 136, 28, 9798-9801	JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 136, 28, 9798-9801	2014/07	Refereed	English	Research paper(scientific journal)	Disclose to all
Nao Hirata, Masato Nakagawa, Yuto Fujibayashi, Kaori Yamauchi, Asako Murata, Itsunari Minami, Maiko Tomioka, Takayuki Kondo, Ting-Fang Kuo, Hiroshi Endo, Haruhisa Inoue, Shin-ichi Sato, Shin Ando, Yoshinori Kawazoe, Kazuhiro Aiba, Koh Nagata, Eihachiro Kawase, Young-Tae Chang, Hirofumi Suemori, Koji Eto, Hiromitsu Nakauchi, Shinya Yamanaka, Norio Nakatsuji, Kazumitsu Ueda, Motonari Uesugi	Nao Hirata, Masato Nakagawa, Yuto Fujibayashi, Kaori Yamauchi, Asako Murata, Itsunari Minami, Maiko Tomioka, Takayuki Kondo, Ting-Fang Kuo, Hiroshi Endo, Haruhisa Inoue, Shin-ichi Sato, Shin Ando, Yoshinori Kawazoe, Kazuhiro Aiba, Koh Nagata, Eihachiro Kawase, Young-Tae Chang, Hirofumi Suemori, Koji Eto, Hiromitsu Nakauchi, Shinya Yamanaka, Norio Nakatsuji, Kazumitsu Ueda, Motonari Uesugi	Nao Hirata, Masato Nakagawa, Yuto Fujibayashi, Kaori Yamauchi, Asako Murata, Itsunari Minami, Maiko Tomioka, Takayuki Kondo, Ting-Fang Kuo, Hiroshi Endo, Haruhisa Inoue, Shin-ichi Sato, Shin Ando, Yoshinori Kawazoe, Kazuhiro Aiba, Koh Nagata, Eihachiro Kawase, Young-Tae Chang, Hirofumi Suemori, Koji Eto, Hiromitsu Nakauchi, Shinya Yamanaka, Norio Nakatsuji, Kazumitsu Ueda, Motonari Uesugi	A Chemical Probe that Labels Human Pluripotent Stem Cells	A Chemical Probe that Labels Human Pluripotent Stem Cells	A Chemical Probe that Labels Human Pluripotent Stem Cells	CELL REPORTS, 6, 6, 1165-1174	CELL REPORTS, 6, 6, 1165-1174	CELL REPORTS, 6, 6, 1165-1174	2014/03	Refereed	English	Research paper(scientific journal)	Disclose to all
Daisuke Sakano, Nobuaki Shiraki, Kazuhide Kikawa, Taiji Yamazoe, Masateru Kataoka, Kahoko Umeda, Kimi Araki, Di Mao, Shirou Matsumoto, Naomi Nakagata, Olov Andersson, Didier Stainier, Fumio Endo, Kazuhiko Kume, Motonari Uesugi, Shoen Kume	Sakano D, Shiraki N, Kikawa K, Yamazoe T, Kataoka M, Umeda K, Araki K, Mao D, Matsumoto S, Nakagata N, Andersson O, Stainier D, Endo F, Kume K, Uesugi M, Kume S	Daisuke Sakano, Nobuaki Shiraki, Kazuhide Kikawa, Taiji Yamazoe, Masateru Kataoka, Kahoko Umeda, Kimi Araki, Di Mao, Shirou Matsumoto, Naomi Nakagata, Olov Andersson, Didier Stainier, Fumio Endo, Kazuhiko Kume, Motonari Uesugi, Shoen Kume	VMAT2 identified as a regulator of late-stage beta-cell differentiation	VMAT2 identified as a regulator of late-stage β-cell differentiation.	VMAT2 identified as a regulator of late-stage beta-cell differentiation	NATURE CHEMICAL BIOLOGY, 10, 2, 141-148	Nature chemical biology, 10, 2, 141-148	NATURE CHEMICAL BIOLOGY, 10, 2, 141-148	2014/02	Refereed	English	Research paper(scientific journal)	Disclose to all
Naohiro Takemoto, Tetsuya Suehara, Heidie L. Frisco, Shin-ichi Sato, Takuhito Sezaki, Kosuke Kusamori, Yoshinori Kawazoe, Sun Min Park, Sayumi Yamazoe, Yoshiyuki Mizuhata, Rintaro Inoue, Gavin J. Miller, Steen U. Hansen, Gordon C. Jayson, John M. Gardiner, Toshiji Kanaya, Norihiro Tokitoh, Kazumitsu Ueda, Yoshinobu Takakura, Noriyuki Kioka, Makiya Nishikawa, Motonari Uesugi	Naohiro Takemoto, Tetsuya Suehara, Heidie L. Frisco, Shin-ichi Sato, Takuhito Sezaki, Kosuke Kusamori, Yoshinori Kawazoe, Sun Min Park, Sayumi Yamazoe, Yoshiyuki Mizuhata, Rintaro Inoue, Gavin J. Miller, Steen U. Hansen, Gordon C. Jayson, John M. Gardiner, Toshiji Kanaya, Norihiro Tokitoh, Kazumitsu Ueda, Yoshinobu Takakura, Noriyuki Kioka, Makiya Nishikawa, Motonari Uesugi	Naohiro Takemoto, Tetsuya Suehara, Heidie L. Frisco, Shin-ichi Sato, Takuhito Sezaki, Kosuke Kusamori, Yoshinori Kawazoe, Sun Min Park, Sayumi Yamazoe, Yoshiyuki Mizuhata, Rintaro Inoue, Gavin J. Miller, Steen U. Hansen, Gordon C. Jayson, John M. Gardiner, Toshiji Kanaya, Norihiro Tokitoh, Kazumitsu Ueda, Yoshinobu Takakura, Noriyuki Kioka, Makiya Nishikawa, Motonari Uesugi	Small-Molecule-Induced Clustering of Heparan Sulfate Promotes Cell Adhesion	Small-Molecule-Induced Clustering of Heparan Sulfate Promotes Cell Adhesion	Small-Molecule-Induced Clustering of Heparan Sulfate Promotes Cell Adhesion	JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 135, 30, 11032-11039	JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 135, 30, 11032-11039	JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 135, 30, 11032-11039	2013/07	Refereed	English	Research paper(scientific journal)	Disclose to all
Takayoshi Suzuki, Midori A. Arai, Mitsue Nakashima, Motonari Uesugi	Takayoshi Suzuki, Midori A. Arai, Mitsue Nakashima, Motonari Uesugi	Takayoshi Suzuki, Midori A. Arai, Mitsue Nakashima, Motonari Uesugi	Merging Chemistry and Biology in Emerging Countries	Merging Chemistry and Biology in Emerging Countries	Merging Chemistry and Biology in Emerging Countries	CHEMISTRY & BIOLOGY, 20, 4, 461-465	CHEMISTRY & BIOLOGY, 20, 4, 461-465	CHEMISTRY & BIOLOGY, 20, 4, 461-465	2013/04	Refereed	English	Research paper(scientific journal)	Disclose to all
Dongju Jung, Lutfi Abu-Elheiga, Rie Ayuzawa, Ziwei Gu, Takashi Shirakawa, Yukio Fujiki, Norio Nakatsuji, Salih J. Wakil, Motonari Uesugi	Dongju Jung, Lutfi Abu-Elheiga, Rie Ayuzawa, Ziwei Gu, Takashi Shirakawa, Yukio Fujiki, Norio Nakatsuji, Salih J. Wakil, Motonari Uesugi	Dongju Jung, Lutfi Abu-Elheiga, Rie Ayuzawa, Ziwei Gu, Takashi Shirakawa, Yukio Fujiki, Norio Nakatsuji, Salih J. Wakil, Motonari Uesugi	Mislocalization and inhibition of acetyl-CoA carboxylase 1 by a synthetic small molecule	Mislocalization and inhibition of acetyl-CoA carboxylase 1 by a synthetic small molecule	Mislocalization and inhibition of acetyl-CoA carboxylase 1 by a synthetic small molecule	BIOCHEMICAL JOURNAL, 448, 3, 409-416	BIOCHEMICAL JOURNAL, 448, 3, 409-416	BIOCHEMICAL JOURNAL, 448, 3, 409-416	2012/12	Refereed	English	Research paper(scientific journal)	Disclose to all
Itsunari Minami, Kohei Yamada, Tomomi G. Otsuji, Takuya Yamamoto, Yan Shen, Shinya Otsuka, Shin Kadota, Nobuhiro Morone, Maneesha Barve, Yasuyuki Asai, Tatyana Tenkova-Heuser, John E. Heuser, Motonari Uesugi, Kazuhiro Aiba, Norio Nakatsuji	Itsunari Minami, Kohei Yamada, Tomomi G. Otsuji, Takuya Yamamoto, Yan Shen, Shinya Otsuka, Shin Kadota, Nobuhiro Morone, Maneesha Barve, Yasuyuki Asai, Tatyana Tenkova-Heuser, John E. Heuser, Motonari Uesugi, Kazuhiro Aiba, Norio Nakatsuji	Itsunari Minami, Kohei Yamada, Tomomi G. Otsuji, Takuya Yamamoto, Yan Shen, Shinya Otsuka, Shin Kadota, Nobuhiro Morone, Maneesha Barve, Yasuyuki Asai, Tatyana Tenkova-Heuser, John E. Heuser, Motonari Uesugi, Kazuhiro Aiba, Norio Nakatsuji	A Small Molecule that Promotes Cardiac Differentiation of Human Pluripotent Stem Cells under Defined, Cytokine- and Xeno-free Conditions	A Small Molecule that Promotes Cardiac Differentiation of Human Pluripotent Stem Cells under Defined, Cytokine- and Xeno-free Conditions	A Small Molecule that Promotes Cardiac Differentiation of Human Pluripotent Stem Cells under Defined, Cytokine- and Xeno-free Conditions	CELL REPORTS, 2, 5, 1448-1460	CELL REPORTS, 2, 5, 1448-1460	CELL REPORTS, 2, 5, 1448-1460	2012/11	Refereed	English	Research paper(scientific journal)	Disclose to all
Takashii Morii, Motonari Uesugi	Takashii Morii, Motonari Uesugi	Takashii Morii, Motonari Uesugi	Two Days of Experiments in Vietnam: Asian Chemical Biology Initiative, Hanoi Meeting	Two Days of Experiments in Vietnam: Asian Chemical Biology Initiative, Hanoi Meeting	Two Days of Experiments in Vietnam: Asian Chemical Biology Initiative, Hanoi Meeting	ACS CHEMICAL BIOLOGY, 7, 4, 623-625	ACS CHEMICAL BIOLOGY, 7, 4, 623-625	ACS CHEMICAL BIOLOGY, 7, 4, 623-625	2012/04	Refereed	English		Disclose to all
Bilon Khambu, Motonari Uesugi, Yoshinori Kawazoe	Bilon Khambu, Motonari Uesugi, Yoshinori Kawazoe	Bilon Khambu, Motonari Uesugi, Yoshinori Kawazoe	Translational repression stabilizes messenger RNA of autophagy-related genes	Translational repression stabilizes messenger RNA of autophagy-related genes	Translational repression stabilizes messenger RNA of autophagy-related genes	GENES TO CELLS, 16, 8, 857-867	GENES TO CELLS, 16, 8, 857-867	GENES TO CELLS, 16, 8, 857-867	2011/08	Refereed	English	Research paper(scientific journal)	Disclose to all
Shinji Kamisuki, Takashi Shirakawa, Akira Kugimiya, Lutfi Abu-Elheiga, Hea-Young Park Choo, Kohei Yamada, Hiroki Shimogawa, Salih J. Wakil, Motonari Uesugi	Shinji Kamisuki, Takashi Shirakawa, Akira Kugimiya, Lutfi Abu-Elheiga, Hea-Young Park Choo, Kohei Yamada, Hiroki Shimogawa, Salih J. Wakil, Motonari Uesugi	Shinji Kamisuki, Takashi Shirakawa, Akira Kugimiya, Lutfi Abu-Elheiga, Hea-Young Park Choo, Kohei Yamada, Hiroki Shimogawa, Salih J. Wakil, Motonari Uesugi	Synthesis and Evaluation of Diarylthiazole Derivatives That Inhibit Activation of Sterol Regulatory Element-Binding Proteins	Synthesis and Evaluation of Diarylthiazole Derivatives That Inhibit Activation of Sterol Regulatory Element-Binding Proteins	Synthesis and Evaluation of Diarylthiazole Derivatives That Inhibit Activation of Sterol Regulatory Element-Binding Proteins	JOURNAL OF MEDICINAL CHEMISTRY, 54, 13, 4923-4927	JOURNAL OF MEDICINAL CHEMISTRY, 54, 13, 4923-4927	JOURNAL OF MEDICINAL CHEMISTRY, 54, 13, 4923-4927	2011/07	Refereed	English	Research paper(scientific journal)	Disclose to all
Eriko Sumiya, Hiroki Shimogawa, Hiroaki Sasaki, Masato Tsutsumi, Ken'ichi Yoshita, Makoto Ojika, Kiyotake Suenaga, Motonari Uesugi	Eriko Sumiya, Hiroki Shimogawa, Hiroaki Sasaki, Masato Tsutsumi, Ken'ichi Yoshita, Makoto Ojika, Kiyotake Suenaga, Motonari Uesugi	Eriko Sumiya, Hiroki Shimogawa, Hiroaki Sasaki, Masato Tsutsumi, Ken'ichi Yoshita, Makoto Ojika, Kiyotake Suenaga, Motonari Uesugi	Cell-Morphology Profiling of a Natural Product Library Identifies Bisebromoamide and Miuraenamide A as Actin Filament Stabilizers	Cell-Morphology Profiling of a Natural Product Library Identifies Bisebromoamide and Miuraenamide A as Actin Filament Stabilizers	Cell-Morphology Profiling of a Natural Product Library Identifies Bisebromoamide and Miuraenamide A as Actin Filament Stabilizers	ACS CHEMICAL BIOLOGY, 6, 5, 425-431	ACS CHEMICAL BIOLOGY, 6, 5, 425-431	ACS CHEMICAL BIOLOGY, 6, 5, 425-431	2011/05	Refereed	English	Research paper(scientific journal)	Disclose to all
Takashi Shirakawa, Yoshinori Kawazoe, Tomoko Tsujikawa, Dongju Jung, Shin-ichi Sato, Motonari Uesugi	Takashi Shirakawa, Yoshinori Kawazoe, Tomoko Tsujikawa, Dongju Jung, Shin-ichi Sato, Motonari Uesugi	Takashi Shirakawa, Yoshinori Kawazoe, Tomoko Tsujikawa, Dongju Jung, Shin-ichi Sato, Motonari Uesugi	Deactivation of STAT6 through Serine 707 Phosphorylation by JNK	Deactivation of STAT6 through Serine 707 Phosphorylation by JNK	Deactivation of STAT6 through Serine 707 Phosphorylation by JNK	JOURNAL OF BIOLOGICAL CHEMISTRY, 286, 5, 4003-4010	JOURNAL OF BIOLOGICAL CHEMISTRY, 286, 5, 4003-4010	JOURNAL OF BIOLOGICAL CHEMISTRY, 286, 5, 4003-4010	2011/02	Refereed	English	Research paper(scientific journal)	Disclose to all
Shin-ichi Sato, Asako Murata, Tsubasa Orihara, Takashi Shirakawa, Kiyotake Suenaga, Hideo Kigoshi, Motonari Uesugi	Shin-ichi Sato, Asako Murata, Tsubasa Orihara, Takashi Shirakawa, Kiyotake Suenaga, Hideo Kigoshi, Motonari Uesugi	Shin-ichi Sato, Asako Murata, Tsubasa Orihara, Takashi Shirakawa, Kiyotake Suenaga, Hideo Kigoshi, Motonari Uesugi	Marine Natural Product Aurilide Activates the OPA1-Mediated Apoptosis by Binding to Prohibitin	Marine Natural Product Aurilide Activates the OPA1-Mediated Apoptosis by Binding to Prohibitin	Marine Natural Product Aurilide Activates the OPA1-Mediated Apoptosis by Binding to Prohibitin	CHEMISTRY & BIOLOGY, 18, 1, 131-139	CHEMISTRY & BIOLOGY, 18, 1, 131-139	CHEMISTRY & BIOLOGY, 18, 1, 131-139	2011/01	Refereed	English	Research paper(scientific journal)	Disclose to all
Yoshinori Kawazoe, Hiroki Shimogawa, Ayato Sato, Motonari Uesugi	Yoshinori Kawazoe, Hiroki Shimogawa, Ayato Sato, Motonari Uesugi	Yoshinori Kawazoe, Hiroki Shimogawa, Ayato Sato, Motonari Uesugi	A Mitochondrial Surface-Specific Fluorescent Probe Activated by Bioconversion	A Mitochondrial Surface-Specific Fluorescent Probe Activated by Bioconversion	A Mitochondrial Surface-Specific Fluorescent Probe Activated by Bioconversion	ANGEWANDTE CHEMIE-INTERNATIONAL EDITION, 50, 24, 5478-5481	ANGEWANDTE CHEMIE-INTERNATIONAL EDITION, 50, 24, 5478-5481	ANGEWANDTE CHEMIE-INTERNATIONAL EDITION, 50, 24, 5478-5481	2011	Refereed	English	Research paper(scientific journal)	Disclose to all
Asako Murata, Shin-ichi Sato, Yoshinori Kawazoe, Motonari Uesugi	Asako Murata, Shin-ichi Sato, Yoshinori Kawazoe, Motonari Uesugi	Asako Murata, Shin-ichi Sato, Yoshinori Kawazoe, Motonari Uesugi	Small-molecule fluorescent probes for specific RNA targets	Small-molecule fluorescent probes for specific RNA targets	Small-molecule fluorescent probes for specific RNA targets	CHEMICAL COMMUNICATIONS, 47, 16, 4712-4714	CHEMICAL COMMUNICATIONS, 47, 16, 4712-4714	CHEMICAL COMMUNICATIONS, 47, 16, 4712-4714	2011	Refereed	English	Research paper(scientific journal)	Disclose to all
Shin-ichi Sato, Asako Murata, Takashi Shirakawa, Motonari Uesugi	Shin-ichi Sato, Asako Murata, Takashi Shirakawa, Motonari Uesugi	Shin-ichi Sato, Asako Murata, Takashi Shirakawa, Motonari Uesugi	Biochemical Target Isolation for Novices: Affinity-Based Strategies	Biochemical Target Isolation for Novices: Affinity-Based Strategies	Biochemical Target Isolation for Novices: Affinity-Based Strategies	CHEMISTRY & BIOLOGY, 17, 6, 616-623	CHEMISTRY & BIOLOGY, 17, 6, 616-623	CHEMISTRY & BIOLOGY, 17, 6, 616-623	2010/06	Refereed	English		Disclose to all
S. Yamazoe, H. Shimogawa, S.-i. Sato, J.D. Esko, M. Uesugi	S. Yamazoe, H. Shimogawa, S.-i. Sato, J.D. Esko, M. Uesugi	S. Yamazoe, H. Shimogawa, S.-i. Sato, J.D. Esko, M. Uesugi	A Dumbbell-Shaped Small Molecule that Promotes Cell Adhesion and Growth (DOI:10.1016/j.chembiol.2009.06.008)	A Dumbbell-Shaped Small Molecule that Promotes Cell Adhesion and Growth (DOI:10.1016/j.chembiol.2009.06.008)	A Dumbbell-Shaped Small Molecule that Promotes Cell Adhesion and Growth (DOI:10.1016/j.chembiol.2009.06.008)	Chemistry and Biology, 17, 3, 310-	Chemistry and Biology, 17, 3, 310-	Chemistry and Biology, 17, 3, 310-	2010	Refereed	English		Disclose to all
Shinji Kamisuki, Qian Mao, Lutfi Abu-Elheiga, Ziwei Gu, Akira Kugimiya, Youngjoo Kwon, Tokuyuki Shinohara, Yoshinori Kawazoe, Shin-ichi Sato, Koko Asakura, Hea-Young Park Choo, Juro Sakai, Salih J. Wakil, Motonari Uesugi	Shinji Kamisuki, Qian Mao, Lutfi Abu-Elheiga, Ziwei Gu, Akira Kugimiya, Youngjoo Kwon, Tokuyuki Shinohara, Yoshinori Kawazoe, Shin-ichi Sato, Koko Asakura, Hea-Young Park Choo, Juro Sakai, Salih J. Wakil, Motonari Uesugi	Shinji Kamisuki, Qian Mao, Lutfi Abu-Elheiga, Ziwei Gu, Akira Kugimiya, Youngjoo Kwon, Tokuyuki Shinohara, Yoshinori Kawazoe, Shin-ichi Sato, Koko Asakura, Hea-Young Park Choo, Juro Sakai, Salih J. Wakil, Motonari Uesugi	A Small Molecule That Blocks Fat Synthesis By Inhibiting the Activation of SREBP	A Small Molecule That Blocks Fat Synthesis By Inhibiting the Activation of SREBP	A Small Molecule That Blocks Fat Synthesis By Inhibiting the Activation of SREBP	CHEMISTRY & BIOLOGY, 16, 8, 882-892	CHEMISTRY & BIOLOGY, 16, 8, 882-892	CHEMISTRY & BIOLOGY, 16, 8, 882-892	2009/08	Refereed	English	Research paper(scientific journal)	Disclose to all
Sayumi Yamazoe, Hiroki Shimogawa, Shin-ichi Sato, Jeffrey D. Esko, Motonari Uesugi	Sayumi Yamazoe, Hiroki Shimogawa, Shin-ichi Sato, Jeffrey D. Esko, Motonari Uesugi	Sayumi Yamazoe, Hiroki Shimogawa, Shin-ichi Sato, Jeffrey D. Esko, Motonari Uesugi	A Dumbbell-Shaped Small Molecule that Promotes Cell Adhesion and Growth	A Dumbbell-Shaped Small Molecule that Promotes Cell Adhesion and Growth	A Dumbbell-Shaped Small Molecule that Promotes Cell Adhesion and Growth	CHEMISTRY & BIOLOGY, 16, 7, 773-782	CHEMISTRY & BIOLOGY, 16, 7, 773-782	CHEMISTRY & BIOLOGY, 16, 7, 773-782	2009/07	Refereed	English	Research paper(scientific journal)	Disclose to all
Dongju Jung, Hiroki Shimogawa, Youngjoo Kwon, Qian Mao, Shin-ichi Sato, Shinji Kamisuki, Hideo Kigoshi, Motonari Uesugi	Dongju Jung, Hiroki Shimogawa, Youngjoo Kwon, Qian Mao, Shin-ichi Sato, Shinji Kamisuki, Hideo Kigoshi, Motonari Uesugi	Dongju Jung, Hiroki Shimogawa, Youngjoo Kwon, Qian Mao, Shin-ichi Sato, Shinji Kamisuki, Hideo Kigoshi, Motonari Uesugi	Wrenchnolol Derivative Optimized for Gene Activation in Cells	Wrenchnolol Derivative Optimized for Gene Activation in Cells	Wrenchnolol Derivative Optimized for Gene Activation in Cells	JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 131, 13, 4774-4782	JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 131, 13, 4774-4782	JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 131, 13, 4774-4782	2009/04	Refereed	English	Research paper(scientific journal)	Disclose to all
Y. C. Henderson, M. J. Frederick, A. Jayakumar, Y. Choi, M. T. Wang, Y. Kang, R. Evans, P. M. Spring, M. Uesugi, G. L. Clayman	Y. C. Henderson, M. J. Frederick, A. Jayakumar, Y. Choi, M. T. Wang, Y. Kang, R. Evans, P. M. Spring, M. Uesugi, G. L. Clayman	Y. C. Henderson, M. J. Frederick, A. Jayakumar, Y. Choi, M. T. Wang, Y. Kang, R. Evans, P. M. Spring, M. Uesugi, G. L. Clayman	Human LBP-32/MGR is a repressor of the P450scc in human choriocarcinoma cell line JEG-3	Human LBP-32/MGR is a repressor of the P450scc in human choriocarcinoma cell line JEG-3	Human LBP-32/MGR is a repressor of the P450scc in human choriocarcinoma cell line JEG-3	PLACENTA, 28, 2-3, 152-160	PLACENTA, 28, 2-3, 152-160	PLACENTA, 28, 2-3, 152-160	2007/02		English	Research paper(scientific journal)	Disclose to all
Shin-ichi Sato, Youngjoo Kwon, Shinji Kamisuki, Neeta Srivastava, Qian Mao, Yoshinori Kawazoe, Motonari Uesugi	Shin-ichi Sato, Youngjoo Kwon, Shinji Kamisuki, Neeta Srivastava, Qian Mao, Yoshinori Kawazoe, Motonari Uesugi	Shin-ichi Sato, Youngjoo Kwon, Shinji Kamisuki, Neeta Srivastava, Qian Mao, Yoshinori Kawazoe, Motonari Uesugi	Polyproline-rod approach to isolating protein targets of bioactive small molecules: Isolation of a new target of indomethacin	Polyproline-rod approach to isolating protein targets of bioactive small molecules: Isolation of a new target of indomethacin	Polyproline-rod approach to isolating protein targets of bioactive small molecules: Isolation of a new target of indomethacin	JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 129, 4, 873-880	JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 129, 4, 873-880	JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 129, 4, 873-880	2007/01	Refereed	English	Research paper(scientific journal)	Disclose to all
DJ Jung, YM Choi, M Uesugi	DJ Jung, YM Choi, M Uesugi	DJ Jung, YM Choi, M Uesugi	Small organic molecules that modulate gene transcription	Small organic molecules that modulate gene transcription	Small organic molecules that modulate gene transcription	DRUG DISCOVERY TODAY, 11, 9-10, 452-457	DRUG DISCOVERY TODAY, 11, 9-10, 452-457	DRUG DISCOVERY TODAY, 11, 9-10, 452-457	2006/05	Refereed	English		Disclose to all
YM Choi, H Shimogawa, K Murakami, L Ramdas, W Zhang, J Qin, M Uesugi	YM Choi, H Shimogawa, K Murakami, L Ramdas, W Zhang, J Qin, M Uesugi	YM Choi, H Shimogawa, K Murakami, L Ramdas, W Zhang, J Qin, M Uesugi	Chemical genetic identification of the IGF-linked pathway that is mediated by STAT6 and MFP2	Chemical genetic identification of the IGF-linked pathway that is mediated by STAT6 and MFP2	Chemical genetic identification of the IGF-linked pathway that is mediated by STAT6 and MFP2	CHEMISTRY & BIOLOGY, 13, 3, 241-249	CHEMISTRY & BIOLOGY, 13, 3, 241-249	CHEMISTRY & BIOLOGY, 13, 3, 241-249	2006/03	Refereed	English	Research paper(scientific journal)	Disclose to all
Y Kwonj, HD Arndt, M Qian, Y Choi, Y Kawazoe, PB Dervan, M Uesugi	Y Kwonj, HD Arndt, M Qian, Y Choi, Y Kawazoe, PB Dervan, M Uesugi	Y Kwonj, HD Arndt, M Qian, Y Choi, Y Kawazoe, PB Dervan, M Uesugi	Small molecule transcription factor mimic	Small molecule transcription factor mimic	Small molecule transcription factor mimic	JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 126, 49, 15940-15941	JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 126, 49, 15940-15941	JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 126, 49, 15940-15941	2004/12	Refereed	English	Research paper(scientific journal)	Disclose to all
Y Kawazoe, S Tanaka, M Uesugi	Y Kawazoe, S Tanaka, M Uesugi	Y Kawazoe, S Tanaka, M Uesugi	Chemical genetic identification of the histamine H1 receptor as a stimulator of insulin-induced adipogenesis	Chemical genetic identification of the histamine H1 receptor as a stimulator of insulin-induced adipogenesis	Chemical genetic identification of the histamine H1 receptor as a stimulator of insulin-induced adipogenesis	CHEMISTRY & BIOLOGY, 11, 7, 907-913	CHEMISTRY & BIOLOGY, 11, 7, 907-913	CHEMISTRY & BIOLOGY, 11, 7, 907-913	2004/07	Refereed	English	Research paper(scientific journal)	Disclose to all
Y Choi, M Uesugi	Y Choi, M Uesugi	Y Choi, M Uesugi	Regulation of IGF2 functions by a bioactive small molecule	Regulation of IGF2 functions by a bioactive small molecule	Regulation of IGF2 functions by a bioactive small molecule	FASEB JOURNAL, 18, 8, C219-C219	FASEB JOURNAL, 18, 8, C219-C219	FASEB JOURNAL, 18, 8, C219-C219	2004/05		English		Disclose to all
H Shimogawa, Y Kwon, Q Mao, Y Kawazoe, Y Choi, S Asada, H Kigoshi, M Uesugi	H Shimogawa, Y Kwon, Q Mao, Y Kawazoe, Y Choi, S Asada, H Kigoshi, M Uesugi	H Shimogawa, Y Kwon, Q Mao, Y Kawazoe, Y Choi, S Asada, H Kigoshi, M Uesugi	A wrench-shaped synthetic molecule that modulates a transcription factor - Coactivator interaction	A wrench-shaped synthetic molecule that modulates a transcription factor - Coactivator interaction	A wrench-shaped synthetic molecule that modulates a transcription factor - Coactivator interaction	JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 126, 11, 3461-3471	JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 126, 11, 3461-3471	JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 126, 11, 3461-3471	2004/03	Refereed	English	Research paper(scientific journal)	Disclose to all
S Asada, YM Choi, M Uesugi	S Asada, YM Choi, M Uesugi	S Asada, YM Choi, M Uesugi	A gene-expression inhibitor that targets an alpha-helix-mediated protein interaction	A gene-expression inhibitor that targets an alpha-helix-mediated protein interaction	A gene-expression inhibitor that targets an alpha-helix-mediated protein interaction	JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 125, 17, 4992-4993	JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 125, 17, 4992-4993	JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 125, 17, 4992-4993	2003/04	Refereed	English	Research paper(scientific journal)	Disclose to all
YM Choi, Y Kawazoe, K Murakami, H Misawa, M Uesugi	YM Choi, Y Kawazoe, K Murakami, H Misawa, M Uesugi	YM Choi, Y Kawazoe, K Murakami, H Misawa, M Uesugi	Identification of bioactive molecules by adipogenesis profiling of organic compounds	Identification of bioactive molecules by adipogenesis profiling of organic compounds	Identification of bioactive molecules by adipogenesis profiling of organic compounds	JOURNAL OF BIOLOGICAL CHEMISTRY, 278, 9, 7320-7324	JOURNAL OF BIOLOGICAL CHEMISTRY, 278, 9, 7320-7324	JOURNAL OF BIOLOGICAL CHEMISTRY, 278, 9, 7320-7324	2003/02	Refereed	English	Research paper(scientific journal)	Disclose to all
Jabbur, JR, AD Tabor, XD Cheng, H Wang, M Uesugi, G Lozano, W Zhang	Jabbur, JR, AD Tabor, XD Cheng, H Wang, M Uesugi, G Lozano, W Zhang	Jabbur, JR, AD Tabor, XD Cheng, H Wang, M Uesugi, G Lozano, W Zhang	Mdm-2 binding and TAF(II)31 recruitment is regulated by hydrogen bond disruption between the p53 residues Thr18 and Asp21	Mdm-2 binding and TAF(II)31 recruitment is regulated by hydrogen bond disruption between the p53 residues Thr18 and Asp21	Mdm-2 binding and TAF(II)31 recruitment is regulated by hydrogen bond disruption between the p53 residues Thr18 and Asp21	ONCOGENE, 21, 46, 7100-7113	ONCOGENE, 21, 46, 7100-7113	ONCOGENE, 21, 46, 7100-7113	2002/10	Refereed	English	Research paper(scientific journal)	Disclose to all
Y Choi, S Asada, M Uesugi	Y Choi, S Asada, M Uesugi	Y Choi, S Asada, M Uesugi	Divergent hTAF(II)31-binding motifs hidden in activation domains	Divergent hTAF(II)31-binding motifs hidden in activation domains	Divergent hTAF(II)31-binding motifs hidden in activation domains	JOURNAL OF BIOLOGICAL CHEMISTRY, 275, 21, 15912-15916	JOURNAL OF BIOLOGICAL CHEMISTRY, 275, 21, 15912-15916	JOURNAL OF BIOLOGICAL CHEMISTRY, 275, 21, 15912-15916	2000/05	Refereed	English	Research paper(scientific journal)	Disclose to all
SJ Park, M Uesugi, LJ Sun, GR Crabtree, GL Verdine	SJ Park, M Uesugi, LJ Sun, GR Crabtree, GL Verdine	SJ Park, M Uesugi, LJ Sun, GR Crabtree, GL Verdine	Existence of a second calcineurin binding site on select isoforms of NFAT	Existence of a second calcineurin binding site on select isoforms of NFAT	Existence of a second calcineurin binding site on select isoforms of NFAT	FASEB JOURNAL, 13, 7, A1495-A1495	FASEB JOURNAL, 13, 7, A1495-A1495	FASEB JOURNAL, 13, 7, A1495-A1495	1999/04		English		Disclose to all
M Uesugi, O Nyanguile, H Lu, AJ Levine, GL Verdine	M Uesugi, O Nyanguile, H Lu, AJ Levine, GL Verdine	M Uesugi, O Nyanguile, H Lu, AJ Levine, GL Verdine	Induced alpha helix in the VP16 activation domain upon binding to a human TAF	Induced alpha helix in the VP16 activation domain upon binding to a human TAF	Induced alpha helix in the VP16 activation domain upon binding to a human TAF	SCIENCE, 277, 5330, 1310-1313	SCIENCE, 277, 5330, 1310-1313	SCIENCE, 277, 5330, 1310-1313	1997/08	Refereed	English	Research paper(scientific journal)	Disclose to all
T KUSAKABE, M UESUGI, Y SUGIURA	T KUSAKABE, M UESUGI, Y SUGIURA	T KUSAKABE, M UESUGI, Y SUGIURA	SEQUENCE PREFERENCE FOR STRAND CLEAVAGE OF GAPPED DUPLEXES BY DYNEMICIN-A - POSSIBLE MECHANISM OF SEQUENCE-DEPENDENT DOUBLE-STRANDED BREAKS	SEQUENCE PREFERENCE FOR STRAND CLEAVAGE OF GAPPED DUPLEXES BY DYNEMICIN-A - POSSIBLE MECHANISM OF SEQUENCE-DEPENDENT DOUBLE-STRANDED BREAKS	SEQUENCE PREFERENCE FOR STRAND CLEAVAGE OF GAPPED DUPLEXES BY DYNEMICIN-A - POSSIBLE MECHANISM OF SEQUENCE-DEPENDENT DOUBLE-STRANDED BREAKS	BIOCHEMISTRY, 34, 31, 9944-9950	BIOCHEMISTRY, 34, 31, 9944-9950	BIOCHEMISTRY, 34, 31, 9944-9950	1995/08	Refereed	English	Research paper(scientific journal)	Disclose to all
M UESUGI, T KUSAKABE, Y SUGIURA	M UESUGI, T KUSAKABE, Y SUGIURA	M UESUGI, T KUSAKABE, Y SUGIURA	HYDROPHOBIC DNA-BINDING OF ESPERAMICIN REQUIRES CONFORMATIONAL DISTORTION OF THE HOST DNA	HYDROPHOBIC DNA-BINDING OF ESPERAMICIN REQUIRES CONFORMATIONAL DISTORTION OF THE HOST DNA	HYDROPHOBIC DNA-BINDING OF ESPERAMICIN REQUIRES CONFORMATIONAL DISTORTION OF THE HOST DNA	BIOCHIMICA ET BIOPHYSICA ACTA-GENE STRUCTURE AND EXPRESSION, 1261, 1, 99-106	BIOCHIMICA ET BIOPHYSICA ACTA-GENE STRUCTURE AND EXPRESSION, 1261, 1, 99-106	BIOCHIMICA ET BIOPHYSICA ACTA-GENE STRUCTURE AND EXPRESSION, 1261, 1, 99-106	1995/03	Refereed	English	Research paper(scientific journal)	Disclose to all
R TOTSUKA, Y AIZAWA, M UESUGI, Y OKUNO, T MATSUMOTO, Y SUGIURA	R TOTSUKA, Y AIZAWA, M UESUGI, Y OKUNO, T MATSUMOTO, Y SUGIURA	R TOTSUKA, Y AIZAWA, M UESUGI, Y OKUNO, T MATSUMOTO, Y SUGIURA	RNA CLEAVAGE BY C-1027 CHROMOPHORE, AN ENEDIYNE ANTITUMOR ANTIBIOTIC - HIGH SELECTIVITY TO AN ANTICODON ARM	RNA CLEAVAGE BY C-1027 CHROMOPHORE, AN ENEDIYNE ANTITUMOR ANTIBIOTIC - HIGH SELECTIVITY TO AN ANTICODON ARM	RNA CLEAVAGE BY C-1027 CHROMOPHORE, AN ENEDIYNE ANTITUMOR ANTIBIOTIC - HIGH SELECTIVITY TO AN ANTICODON ARM	BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 208, 1, 168-173	BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 208, 1, 168-173	BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 208, 1, 168-173	1995/03	Refereed	English	Research paper(scientific journal)	Disclose to all
T KUSHIDA, M UESUGI, Y SUGIURA, H KIGOSHI, H TANAKA, J HIROKAWA, M OJIKA, K YAMADA	T KUSHIDA, M UESUGI, Y SUGIURA, H KIGOSHI, H TANAKA, J HIROKAWA, M OJIKA, K YAMADA	T KUSHIDA, M UESUGI, Y SUGIURA, H KIGOSHI, H TANAKA, J HIROKAWA, M OJIKA, K YAMADA	DNA-DAMAGE BY PTAQUILOSIDE, A POTENT BRACKEN CARCINOGEN - DETECTION OF SELECTIVE STRAND BREAKS AND IDENTIFICATION OF DNA CLEAVAGE PRODUCTS	DNA-DAMAGE BY PTAQUILOSIDE, A POTENT BRACKEN CARCINOGEN - DETECTION OF SELECTIVE STRAND BREAKS AND IDENTIFICATION OF DNA CLEAVAGE PRODUCTS	DNA-DAMAGE BY PTAQUILOSIDE, A POTENT BRACKEN CARCINOGEN - DETECTION OF SELECTIVE STRAND BREAKS AND IDENTIFICATION OF DNA CLEAVAGE PRODUCTS	JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 116, 2, 479-486	JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 116, 2, 479-486	JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 116, 2, 479-486	1994/01	Refereed	English	Research paper(scientific journal)	Disclose to all
T KUSAKABE, K MAEKAWA, A ICHIKAWA, M UESUGI, Y SUGIURA	T KUSAKABE, K MAEKAWA, A ICHIKAWA, M UESUGI, Y SUGIURA	T KUSAKABE, K MAEKAWA, A ICHIKAWA, M UESUGI, Y SUGIURA	CONFORMATION-SELECTIVE DNA STRAND BREAKS BY DYNEMICIN - A MOLECULAR WEDGE INTO FLEXIBLE REGIONS OF DNA	CONFORMATION-SELECTIVE DNA STRAND BREAKS BY DYNEMICIN - A MOLECULAR WEDGE INTO FLEXIBLE REGIONS OF DNA	CONFORMATION-SELECTIVE DNA STRAND BREAKS BY DYNEMICIN - A MOLECULAR WEDGE INTO FLEXIBLE REGIONS OF DNA	BIOCHEMISTRY, 32, 43, 11669-11675	BIOCHEMISTRY, 32, 43, 11669-11675	BIOCHEMISTRY, 32, 43, 11669-11675	1993/11	Refereed	English	Research paper(scientific journal)	Disclose to all
M UESUGI, Y SUGIURA	M UESUGI, Y SUGIURA	M UESUGI, Y SUGIURA	NEW INSIGHTS INTO SEQUENCE RECOGNITION PROCESS OF ESPERAMICIN-A(1) AND CALICHEAMICIN-GAMMA-1(I) - ORIGIN OF THEIR SELECTIVITIES AND INDUCED FIT MECHANISM	NEW INSIGHTS INTO SEQUENCE RECOGNITION PROCESS OF ESPERAMICIN-A(1) AND CALICHEAMICIN-GAMMA-1(I) - ORIGIN OF THEIR SELECTIVITIES AND INDUCED FIT MECHANISM	NEW INSIGHTS INTO SEQUENCE RECOGNITION PROCESS OF ESPERAMICIN-A(1) AND CALICHEAMICIN-GAMMA-1(I) - ORIGIN OF THEIR SELECTIVITIES AND INDUCED FIT MECHANISM	BIOCHEMISTRY, 32, 17, 4622-4627	BIOCHEMISTRY, 32, 17, 4622-4627	BIOCHEMISTRY, 32, 17, 4622-4627	1993/05	Refereed	English	Research paper(scientific journal)	Disclose to all
M TOKUDA, K FUJIWARA, T GOMIBUCHI, M HIRAMA, M UESUGI, Y SUGIURA	M TOKUDA, K FUJIWARA, T GOMIBUCHI, M HIRAMA, M UESUGI, Y SUGIURA	M TOKUDA, K FUJIWARA, T GOMIBUCHI, M HIRAMA, M UESUGI, Y SUGIURA	SYNTHESIS OF A HYBRID MOLECULE CONTAINING NEOCARZINOSTATIN CHROMOPHORE ANALOG AND MINOR GROOVE BINDER	SYNTHESIS OF A HYBRID MOLECULE CONTAINING NEOCARZINOSTATIN CHROMOPHORE ANALOG AND MINOR GROOVE BINDER	SYNTHESIS OF A HYBRID MOLECULE CONTAINING NEOCARZINOSTATIN CHROMOPHORE ANALOG AND MINOR GROOVE BINDER	TETRAHEDRON LETTERS, 34, 4, 669-672	TETRAHEDRON LETTERS, 34, 4, 669-672	TETRAHEDRON LETTERS, 34, 4, 669-672	1993/01	Refereed	English	Research paper(scientific journal)	Disclose to all
T SHIRAKI, M UESUGI, Y SUGIURA	T SHIRAKI, M UESUGI, Y SUGIURA	T SHIRAKI, M UESUGI, Y SUGIURA	C-1' HYDROGEN ABSTRACTION OF DEOXYRIBOSE IN DNA STRAND SCISSION BY DYNEMICIN-A	C-1' HYDROGEN ABSTRACTION OF DEOXYRIBOSE IN DNA STRAND SCISSION BY DYNEMICIN-A	C-1' HYDROGEN ABSTRACTION OF DEOXYRIBOSE IN DNA STRAND SCISSION BY DYNEMICIN-A	BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 188, 2, 584-589	BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 188, 2, 584-589	BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 188, 2, 584-589	1992/10	Refereed	English	Research paper(scientific journal)	Disclose to all
M UESUGI, Y SUGIURA	M UESUGI, Y SUGIURA	M UESUGI, Y SUGIURA	PRODUCT ANALYSES IN DNA STRAND SCISSION BY ANTITUMOR ANTIBIOTIC ELSAMICIN-A	PRODUCT ANALYSES IN DNA STRAND SCISSION BY ANTITUMOR ANTIBIOTIC ELSAMICIN-A	PRODUCT ANALYSES IN DNA STRAND SCISSION BY ANTITUMOR ANTIBIOTIC ELSAMICIN-A	BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 186, 1, 580-587	BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 186, 1, 580-587	BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 186, 1, 580-587	1992/07	Refereed	English	Research paper(scientific journal)	Disclose to all
T OWA, A HAUPT, M OTSUKA, S KOBAYASHI, N TOMIOKA, A ITAI, M OHNO, T SHIRAKI, M UESUGI, Y SUGIURA, K MAEDA	T OWA, A HAUPT, M OTSUKA, S KOBAYASHI, N TOMIOKA, A ITAI, M OHNO, T SHIRAKI, M UESUGI, Y SUGIURA, K MAEDA	T OWA, A HAUPT, M OTSUKA, S KOBAYASHI, N TOMIOKA, A ITAI, M OHNO, T SHIRAKI, M UESUGI, Y SUGIURA, K MAEDA	MAN-DESIGNED BLEOMYCINS - SIGNIFICANCE OF THE BINDING-SITES AS ENZYME MODELS AND OF THE STEREOCHEMISTRY OF THE LINKER MOIETY	MAN-DESIGNED BLEOMYCINS - SIGNIFICANCE OF THE BINDING-SITES AS ENZYME MODELS AND OF THE STEREOCHEMISTRY OF THE LINKER MOIETY	MAN-DESIGNED BLEOMYCINS - SIGNIFICANCE OF THE BINDING-SITES AS ENZYME MODELS AND OF THE STEREOCHEMISTRY OF THE LINKER MOIETY	TETRAHEDRON, 48, 7, 1193-1208	TETRAHEDRON, 48, 7, 1193-1208	TETRAHEDRON, 48, 7, 1193-1208	1992/02	Refereed	English	Research paper(scientific journal)	Disclose to all
M HIRAMA, T GOMIBUCHI, K FUJIWARA, Y SUGIURA, M UESUGI	M HIRAMA, T GOMIBUCHI, K FUJIWARA, Y SUGIURA, M UESUGI	M HIRAMA, T GOMIBUCHI, K FUJIWARA, Y SUGIURA, M UESUGI	SYNTHESIS AND DNA-CLEAVING ABILITIES OF FUNCTIONAL NEOCARZINOSTATIN CHROMOPHORE ANALOGS - BASE DISCRIMINATION BY A SIMPLE ALCOHOL	SYNTHESIS AND DNA-CLEAVING ABILITIES OF FUNCTIONAL NEOCARZINOSTATIN CHROMOPHORE ANALOGS - BASE DISCRIMINATION BY A SIMPLE ALCOHOL	SYNTHESIS AND DNA-CLEAVING ABILITIES OF FUNCTIONAL NEOCARZINOSTATIN CHROMOPHORE ANALOGS - BASE DISCRIMINATION BY A SIMPLE ALCOHOL	JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 113, 26, 9851-9853	JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 113, 26, 9851-9853	JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 113, 26, 9851-9853	1991/12	Refereed	English		Disclose to all
M UESUGI, T SEKIDA, S MATSUKI, Y SUGIURA	M UESUGI, T SEKIDA, S MATSUKI, Y SUGIURA	M UESUGI, T SEKIDA, S MATSUKI, Y SUGIURA	SELECTIVE DNA CLEAVAGE BY ELSAMICIN-A AND SWITCH FUNCTION OF ITS AMINO SUGAR GROUP	SELECTIVE DNA CLEAVAGE BY ELSAMICIN-A AND SWITCH FUNCTION OF ITS AMINO SUGAR GROUP	SELECTIVE DNA CLEAVAGE BY ELSAMICIN-A AND SWITCH FUNCTION OF ITS AMINO SUGAR GROUP	BIOCHEMISTRY, 30, 27, 6711-6715	BIOCHEMISTRY, 30, 27, 6711-6715	BIOCHEMISTRY, 30, 27, 6711-6715	1991/07		English	Research paper(scientific journal)	Disclose to all
Y SUGIURA, T ARAKAWA, M UESUGI, T SHIRAKI, H OHKUMA, M KONISHI	Y SUGIURA, T ARAKAWA, M UESUGI, T SHIRAKI, H OHKUMA, M KONISHI	Y SUGIURA, T ARAKAWA, M UESUGI, T SHIRAKI, H OHKUMA, M KONISHI	REDUCTIVE AND NUCLEOPHILIC ACTIVATION PRODUCTS OF DYNEMICIN-A WITH METHYL THIOGLYCOLATE - A RATIONAL MECHANISM FOR DNA CLEAVAGE OF THE THIOL-ACTIVATED DYNEMICIN-A	REDUCTIVE AND NUCLEOPHILIC ACTIVATION PRODUCTS OF DYNEMICIN-A WITH METHYL THIOGLYCOLATE - A RATIONAL MECHANISM FOR DNA CLEAVAGE OF THE THIOL-ACTIVATED DYNEMICIN-A	REDUCTIVE AND NUCLEOPHILIC ACTIVATION PRODUCTS OF DYNEMICIN-A WITH METHYL THIOGLYCOLATE - A RATIONAL MECHANISM FOR DNA CLEAVAGE OF THE THIOL-ACTIVATED DYNEMICIN-A	BIOCHEMISTRY, 30, 12, 2989-2992	BIOCHEMISTRY, 30, 12, 2989-2992	BIOCHEMISTRY, 30, 12, 2989-2992	1991/03	Refereed	English	Research paper(scientific journal)	Disclose to all
Uesugi, M	Uesugi, M	Uesugi, M	Small Molecule Tools for Cell Biology and Cell Therapy	Small Molecule Tools for Cell Biology and Cell Therapy	Small Molecule Tools for Cell Biology and Cell Therapy	Chembiomolecular Science at the Frontier of Chemistry and Biology , 51-58	Chembiomolecular Science at the Frontier of Chemistry and Biology , 51-58	Chembiomolecular Science at the Frontier of Chemistry and Biology , 51-58					Disclose to all
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Misc

Author	Author(Japanese)	Author(English)	Title	Title(Japanese)	Title(English)	Bibliography	Bibliography(Japanese)	Bibliography(English)	Publication date	Language	Publishing type	Disclose
Junichiro Takaya, Motonari Uesugi	Junichiro Takaya, Motonari Uesugi	Junichiro Takaya, Motonari Uesugi	Chemical Biological Analysis of TRPA1 Activation Mechanism	Chemical Biological Analysis of TRPA1 Activation Mechanism	Chemical Biological Analysis of TRPA1 Activation Mechanism	JOURNAL OF SYNTHETIC ORGANIC CHEMISTRY JAPAN, 74, 5, 505-511	JOURNAL OF SYNTHETIC ORGANIC CHEMISTRY JAPAN, 74, 5, 505-511	JOURNAL OF SYNTHETIC ORGANIC CHEMISTRY JAPAN, 74, 5, 505-511	2016/05	Japanese	Book review and document introduction, etc.	Disclose to all
Lutfi Abu-Elheiga, Motonari Uesugi, Salih Wakil	Lutfi Abu-Elheiga, Motonari Uesugi, Salih Wakil	Lutfi Abu-Elheiga, Motonari Uesugi, Salih Wakil	Regulation of de novo lipid synthesis by small organic molecules, fatostatins	Regulation of de novo lipid synthesis by small organic molecules, fatostatins	Regulation of de novo lipid synthesis by small organic molecules, fatostatins	FASEB JOURNAL, 25	FASEB JOURNAL, 25	FASEB JOURNAL, 25	2011/04	English	Summary of the papers read (international conference)	Disclose to all
Gaku Murakami, Haruhisa Inoue, Kayoko Tsukita, Yasuyuki Asai, Yuji Amagai, Kazuhiro Aiba, Hiroki Shimogawa, Motonari Uesugi, Norio Nakatsuji, Ryosuke Takahashi	Gaku Murakami, Haruhisa Inoue, Kayoko Tsukita, Yasuyuki Asai, Yuji Amagai, Kazuhiro Aiba, Hiroki Shimogawa, Motonari Uesugi, Norio Nakatsuji, Ryosuke Takahashi	Gaku Murakami, Haruhisa Inoue, Kayoko Tsukita, Yasuyuki Asai, Yuji Amagai, Kazuhiro Aiba, Hiroki Shimogawa, Motonari Uesugi, Norio Nakatsuji, Ryosuke Takahashi	Chemical library screening identifies a small molecule that downregulates SOD1 transcription for drugs to treat amyotrophic lateral sclerosis	Chemical library screening identifies a small molecule that downregulates SOD1 transcription for drugs to treat amyotrophic lateral sclerosis	Chemical library screening identifies a small molecule that downregulates SOD1 transcription for drugs to treat amyotrophic lateral sclerosis	NEUROSCIENCE RESEARCH, 71, E55-E55	NEUROSCIENCE RESEARCH, 71, E55-E55	NEUROSCIENCE RESEARCH, 71, E55-E55	2011	English	Summary of the papers read (international conference)	Disclose to all
Sayumi Yamazoe, Hiroki Shimogawa, Shin-ichi Sato, Jeffrey D. Esko, Motonari Uesugi	Sayumi Yamazoe, Hiroki Shimogawa, Shin-ichi Sato, Jeffrey D. Esko, Motonari Uesugi	Sayumi Yamazoe, Hiroki Shimogawa, Shin-ichi Sato, Jeffrey D. Esko, Motonari Uesugi	A Dumbbell-Shaped Small Molecule that Promotes Cell Adhesion and Growth (vol 16, pg 773, 2009)	A Dumbbell-Shaped Small Molecule that Promotes Cell Adhesion and Growth (vol 16, pg 773, 2009)	A Dumbbell-Shaped Small Molecule that Promotes Cell Adhesion and Growth (vol 16, pg 773, 2009)	CHEMISTRY & BIOLOGY, 17, 3, 310-310	CHEMISTRY & BIOLOGY, 17, 3, 310-310	CHEMISTRY & BIOLOGY, 17, 3, 310-310	2010/03	English	Other article	Disclose to all
Gaku Murakami, Haruhisa Inoue, Kayoko Tsukita, Yasuyuki Asai, Kazuhiro Aiba, Yuji Amagai, Motonari Uesugi, Norio Nakatsuji, Ryosuke Takahashi	Gaku Murakami, Haruhisa Inoue, Kayoko Tsukita, Yasuyuki Asai, Kazuhiro Aiba, Yuji Amagai, Motonari Uesugi, Norio Nakatsuji, Ryosuke Takahashi	Gaku Murakami, Haruhisa Inoue, Kayoko Tsukita, Yasuyuki Asai, Kazuhiro Aiba, Yuji Amagai, Motonari Uesugi, Norio Nakatsuji, Ryosuke Takahashi	A high-throughput screening assay for drug discovery in SOD1-mediated ALS targeting the transcription of SOD1	A high-throughput screening assay for drug discovery in SOD1-mediated ALS targeting the transcription of SOD1	A high-throughput screening assay for drug discovery in SOD1-mediated ALS targeting the transcription of SOD1	NEUROSCIENCE RESEARCH, 68, E311-E311	NEUROSCIENCE RESEARCH, 68, E311-E311	NEUROSCIENCE RESEARCH, 68, E311-E311	2010	English	Summary of the papers read (international conference)	Disclose to all
Gaku Murakami, Haruhisa Inoue, Kayoko Tsukita, Yasuyuki Asai, Kazuhiro Aiba, Yuji Amagai, Motonari Uesugi, Norio Nakatsuji, Ryosuke Takahashi	Gaku Murakami, Haruhisa Inoue, Kayoko Tsukita, Yasuyuki Asai, Kazuhiro Aiba, Yuji Amagai, Motonari Uesugi, Norio Nakatsuji, Ryosuke Takahashi	Gaku Murakami, Haruhisa Inoue, Kayoko Tsukita, Yasuyuki Asai, Kazuhiro Aiba, Yuji Amagai, Motonari Uesugi, Norio Nakatsuji, Ryosuke Takahashi	Development of a high-throughput screening assay for drug discovery in SOD1-mediated ALS	Development of a high-throughput screening assay for drug discovery in SOD1-mediated ALS	Development of a high-throughput screening assay for drug discovery in SOD1-mediated ALS	NEUROSCIENCE RESEARCH, 65, S120-S120	NEUROSCIENCE RESEARCH, 65, S120-S120	NEUROSCIENCE RESEARCH, 65, S120-S120	2009	English	Summary of the papers read (international conference)	Disclose to all
Y Kwon, H Shimogawa, Q Mao, Y Kawazoe, YM Choi, H Kigoshi, M Uesugi	Y Kwon, H Shimogawa, Q Mao, Y Kawazoe, YM Choi, H Kigoshi, M Uesugi	Y Kwon, H Shimogawa, Q Mao, Y Kawazoe, YM Choi, H Kigoshi, M Uesugi	Wrench-shaped synthetic molecules that modulate gene transcription.	Wrench-shaped synthetic molecules that modulate gene transcription.	Wrench-shaped synthetic molecules that modulate gene transcription.	ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY, 228, U909-U909	ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY, 228, U909-U909	ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY, 228, U909-U909	2004/08	English	Summary of the papers read (international conference)	Disclose to all
Y Choi, Y Kawazoe, K Murakami, M Uesugi	Y Choi, Y Kawazoe, K Murakami, M Uesugi	Y Choi, Y Kawazoe, K Murakami, M Uesugi	Identification of bioactive molecules by adipogenesis profiling of organic compounds	Identification of bioactive molecules by adipogenesis profiling of organic compounds	Identification of bioactive molecules by adipogenesis profiling of organic compounds	FASEB JOURNAL, 17, 4, A605-A605	FASEB JOURNAL, 17, 4, A605-A605	FASEB JOURNAL, 17, 4, A605-A605	2003/03	English	Summary of the papers read (international conference)	Disclose to all
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Books etc

Author	Author(Japanese)	Title	Title(Japanese)	Publisher	Publisher(Japanese)	Publication date	Type	Disclose
日本学術振興会ケミカルバイオロジ, 委員会	日本学術振興会ケミカルバイオロジ, 委員会	ケミカルバイオロジー化合物集研究展開のヒント	ケミカルバイオロジー化合物集研究展開のヒント	オーム社	オーム社	2018/10	Other	Disclose to all
上杉志成	上杉志成	京都大学アイデアが湧いてくる講義サイエンスの発想法	京都大学アイデアが湧いてくる講義サイエンスの発想法	祥伝社黄金文庫	祥伝社黄金文庫	2017/09	Single Work	Disclose to all
上杉志成	上杉志成	京都大学人気講義サイエンスの発想法	京都大学人気講義サイエンスの発想法	祥伝社	祥伝社	2014/04/30	Single Work	Disclose to all
長野哲雄, 菊地和也, 上杉志成, 長田裕之	長野哲雄, 菊地和也, 上杉志成, 長田裕之	ケミカルバイオロジー	ケミカルバイオロジー	共立出版	共立出版	2008/05	Joint Editor	Disclose to all
長野哲雄, 長田裕之, 菊地和也, 上杉志成, 共立出版	長野哲雄, 長田裕之, 菊地和也, 上杉志成, 共立出版	ケミカルバイオロジー PNE 蛋白質核酸酵素 2007年10月号増刊	ケミカルバイオロジー PNE 蛋白質核酸酵素 2007年10月号増刊	共立出版	共立出版	2007	Joint Work	Disclose to all
長野哲雄, 長田裕之, 菊地和也, 上杉志成, 共立出版	長野哲雄, 長田裕之, 菊地和也, 上杉志成, 共立出版	ゲノムサイエンスの新たなる挑戦 PNE 蛋白質核酸酵素 2001年12月号増刊	ゲノムサイエンスの新たなる挑戦 PNE 蛋白質核酸酵素 2001年12月号増刊	共立出版	共立出版	2001	Joint Work	Disclose to all
Title language:

Awards

Title(Japanese)	Title(English)	Organization name(Japanese)	Organization name(English)	Date
若手研究奨励賞	Lymphoma Research Foundation	アメリカリンパ腫研究財団	Young Investigator Award	2001/07/
若手研究奨励賞	Research Scholar Award	アメリカ癌財団	American Cancer Society	2003/07/
ゴールドメダル賞	Gold Medal Award	東京テクノフォーラム21	Tokyo Techno-Forum	2006/04/
学術振興賞	Award for Divisional Scientific Promotions	日本薬学会	The Pharmaceutical Society of Japan	2011/03/
ドイツイノベーションアワードゴットフリード・ワグネル賞 2010 (1等)	German Innovation Award Gottfried Wagener Prize 2010 (1st Prize)	ドイツ科学・イノベーションフォーラム東京、在日ドイツ商工会議所	German Research and Innovation Forum Tokyo & German Chamber of Commerce and Industry in Japan	2011/05/
第49回市村学術賞貢献賞	The 49th Ichimura Prize in Science for Distinguished Achievement	公益財団法人新技術開発財団	The New Technology Development Foundation	2017/04/26

External funds: competitive funds and Grants-in-Aid for Scientific Research (Kakenhi)

Type	Position	Title(Japanese)	Period
基盤研究(B)	Representative	小分子有機化合物を起爆剤とした細胞シグナル解析	2009/04/01-2011/03/31
挑戦的萌芽研究	Representative	転写因子Hes1の振動を制御する小分子化合物（平成26年度分）	2014/04/01-2015/03/31
新学術領域研究（研究領域提案型）	Representative	脂質関連内因性分子の新機能発掘と調節（平成26年度分）	2014/04/01-2015/03/31
基盤研究(S)	Representative	合成小分子化合物による細胞の操作と分析（平成26年度分）	2014/05/30-2015/03/31
基盤研究(S)	Representative	合成小分子化合物による細胞の操作と分析（平成27年度分）	2015/04/01-2016/03/31
挑戦的萌芽研究	Representative	転写因子Hes1の振動を制御する小分子化合物（平成27年度分）	2015/04/01-2016/03/31
新学術領域研究（研究領域提案型）	Representative	脂質関連内因性分子の新機能発掘と調節（平成27年度分）	2015/04/01-2016/03/31
基盤研究(S)	Representative	合成小分子化合物による細胞の操作と分析（平成28年度分）	2016/04/01-2017/03/31
特別研究員奨励費	Representative	ＲＮＡのＧグアドルプレックスを認識する化合物の開発と利用（平成28年度分）	2016/04/01-2017/03/31
挑戦的研究（萌芽）	Representative	人工翻訳後修飾（平成29年度分）	2017/04/01-2018/03/31
基盤研究(S)	Representative	合成小分子化合物による細胞の操作と分析（平成29年度分）	2017/04/01-2018/03/31
新学術領域研究（研究領域提案型）	Representative	人工栄養素結合体の化学シグナル（平成29年度分）	2017/04/01-2018/03/31
特別研究員奨励費	Representative	ＲＮＡのＧグアドルプレックスを認識する化合物の開発と利用（平成29年度分）	2017/04/01-2018/03/31
挑戦的研究（萌芽）	Representative	人工翻訳後修飾（平成30年度分）	2018/04/01-2019/03/31
基盤研究(S)	Representative	合成小分子化合物による細胞の操作と分析（平成30年度分）	2018/04/01-2019/03/31
新学術領域研究（研究領域提案型）	Representative	人工栄養素結合体の化学シグナル（平成30年度分）	2018/04/01-2019/03/31
基盤研究(A)	Representative	自己集合性生理活性小分子の開拓（2019年度分）	2019/04/01-2020/03/31
新学術領域研究（研究領域提案型）	Representative	人工栄養素結合体の化学シグナル（2019年度分）	2019/04/01-2020/03/31
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External funds: other than those above

System	Main person	Title(Japanese)	Title(English)	Period
独立行政法人科学技術振興機構戦略的創造研究推進事業　さきがけ	上杉　志成	生命現象分析のための小分子転写因子創成		2005/10/-2009/03/
独立行政法人科学技術振興機構研究成果最適展開支援事業（A-STEP）フィージビリティスタディ	上杉　志成	細胞接着促進化合物の実用化		2009/11/01-2010/10/31
独立行政法人日本学術振興会最先端・次世代研究開発支援プログラム	上杉志成	合成小分子化合物による細胞の操作と分析(H23-26)	Control and Analysis of Cells by Synthetic Small Molecules	2011/02/-2014/03/31
独立行政法人日本学術振興会アジア研究教育拠点事業	上杉　志成	アジア発ケミカルバイオロジー(H23-27)	Asian Chemical Biology Initiative	2011/04/01-2016/03/31
独立行政法人科学技術振興機構　戦略的創造研究推進事業CREST	上杉　志成	ケミカルバイオロジーによる脂質内因性分子の新機能研究(H26年度分)	Chemical biological exploration of new functions of endogenous lipid-related molecules	2014/10/01-2015/03/31
国立研究開発法人日本医療研究開発機構(AMED) 革新的先端研究開発支援事業ユニットタイプ「疾患における代謝産物の解析および代謝制御に基づく革新的医療基盤技術の創出」	上杉　志成	ケミカルバイオロジーによる脂質内因性分子の新機能研究(H27-31年度分)	Chemical biological exploration of new functions of endogenous lipid-related molecules	2015/04/01-2020/03/31
文部科学省	上杉　志成	転写機能をターゲットとした創薬「転写を標的とした革新的抗がん化合物シーズ」(H26年度分)		2014/12/21-2015/03/31
国立研究開発法人日本医療研究開発機構(AMED) 次世代がん研究シーズ戦略的育成プログラム　革新的がん医療シーズ育成領域	上杉志成	転写機能をターゲットとした創薬「転写を標的とした革新的抗がん化合物シーズ」 (H27年度分)		2015/04/01-2016/03/31
独立行政法人　科学技術振興機構シーズ発掘試験研究	上杉　志成	アドヘサミンの応用開拓研究		2008/08/12-2009/03/31
アジア研究教育拠点事業	上杉　志成	アジア発ケミカルバイオロジー（平成27年度分）		2015/04/01-2016/03/31
研究拠点形成事業　B.アジア・アフリカ学術基盤形成型	上杉　志成	ケミカルバイオロジー戦略的アジア拠点（平成28年度分）		2016/04/01-2017/03/31
研究拠点形成事業　B.アジア・アフリカ学術基盤形成型	上杉志成	ケミカルバイオロジー戦略的アジア拠点（平成29年度分）		2017/04/01-2018/03/31
研究拠点形成事業　B.アジア・アフリカ学術基盤形成型	上杉志成	ケミカルバイオロジー戦略的アジア拠点（平成30年度分）		2018/04/01-2019/03/31
研究拠点形成事業　B.アジア・アフリカ学術基盤形成型	上杉　志成	協調型アジアケミカルバイオロジー拠点（2019年度分）		2019/04/01-2020/03/31
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Teaching subject(s)

Name(Japanese)	Name(English)	Term	Department	Period
生命の有機化学	The Organic Chemistry of Life	前期	全学共通科目	2011/04-2012/03
生命の有機化学	The Organic Chemistry of Life	前期	全学共通科目	2012/04-2013/03
細胞と物質をつなぐ科学	Integrated Cell-Material Sciences	後期	全学共通科目	2012/04-2013/03
生命の有機化学	The Organic Chemistry of Life	前期	全学共通科目	2013/04-2014/03
生命の有機化学	The Organic Chemistry of Life	前期	全学共通科目	2014/04-2015/03
先端生命科学	Frontier in Life Sciences	通年集中	生命科学研究科	2015/04-2016/03
生命の有機化学	The Organic Chemistry of Life	前期	全学共通科目	2015/04-2016/03
生命の有機化学	Organic Chemistry of Life	前期	全学共通科目	2016/04-2017/03
生命の有機化学	Organic Chemistry of Life	前期	全学共通科目	2017/04-2018/03
生命の有機化学	Organic Chemistry of Life	前期	全学共通科目	2018/04-2019/03
生命の有機化学	Organic Chemistry of Life	前期	全学共通科目	2019/04-2020/03
生命の有機化学	Organic Chemistry of Life	前期集中	全学共通科目	2020/04-2021/03
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Faculty management (title, position)

Title	Period
ケミカルスクリーニングセンター長	2011/11/25-2015/11/24
物質－細胞統合システム拠点副拠点長	2013/01/01-2017/03/31
化学研究所運営委員会委員	2017/04/01-2018/03/31
化学研究所広報委員会委員	2017/04/01-2018/03/31
化学研究所将来問題・研究活性化委員会委員	2017/04/01-2018/03/31
物質－細胞統合システム拠点連携主任研究者・副拠点長	2017/04/01-2018/03/31
化学研究所ゲノムネット推進室運営委員会委員	2018/04/01-2020/03/31
化学研究所広報委員会委員長	2018/04/01-2019/03/31
化学研究所将来問題・研究活性化委員会委員	2018/04/01-2019/03/31
物質－細胞統合システム拠点連携主任研究者・副拠点長	2018/04/01-2019/03/31
化学研究所広報委員会委員長	2019/04/01-2020/03/31
化学研究所将来問題・研究活性化委員会委員	2019/04/01-2020/03/31
物質－細胞統合システム拠点連携主任研究者・副拠点長	2019/04/01-2020/03/31
化学研究所広報委員会委員長	2020/04/01-2021/03/31
化学研究所財務委員会委員	2020/04/01-2021/03/31
化学研究所情報セキュリティ委員会委員	2020/04/01-2021/03/31
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Other activities (private companies, NPOs, etc.)

Company name	Activity	Period
大鵬薬品工業株式会社	技術アドバイザー	2001-
公益財団法人アステラス病態代謝研究会	学術委員、選考委員	2012/06/24-2020/06/30
内藤記念科学振興財団	選考委員会委員	2013/04/01-
FGH Biotech, Inc. (USA)	Co-Founder	2014/01/-
日本におけるケミカルバイオロジーの新展開第189委員会	委員	2015/04/01-2020/03/31
公益財団法人上原記念生命科学財団	選考委員会委員	2016/04/09-2020/03/31
国立研究開発法人日本医療研究開発機構	AMED課題評価委員　画期的医薬品等の創出をめざす脂質の生理活性と機能の解明	2017/04/01-2019/03/31
文部科学省	科学技術・学術審議会専門委員	2017/04/24-2021/02/14
国立研究開発法人科学技術振興機構	領域アドバイザー　疾患における代謝産物の解析および代謝制御に基づく革新的医療基盤技術の創出	2017/06/25-2019/03/31
Fudan University, School of Pharmacy	Distinguished Professor of Shanghai Thousand Talent Program	2017/07/01-2020/06/30
国立研究開発法人科学技術振興機構	パネルメンバー	2019/04/01-2020/03/31
国立研究開発法人科学技術振興機構	領域アドバイザー	2019/06/01-2021/03/31
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Other activities (other)

Activity	Misc	Period
edX講義「The Chemistry of Life」の提供	ハーバード大学とMITが運営するインターネット教育機関edXに、日本初の講義「The Chemistry of Life（生命の化学）」を英語で世界配信。	2014/04/-

上杉 志成

上杉志成