上杉志成

Last Update: 2019/06/27 19:25:01

Name(Kanji/Kana/Abecedarium Latinum)

上杉志成/ウエスギモトナリ/Uesugi, Motonari

Primary Affiliation(Org1/Job title)

Institute for Chemical Research (ICR)/Professor

Affiliated programs (koza)

Org1	Job title
Graduate Schools Medicine	Professor
Graduate Schools Medicine	Professor

Concurrent Affiliation

Org1	Job title
物質－細胞統合システム拠点	連携ＰＩ
Graduate Schools Medicine

Contact Address

Type	Address(Japanese)	Address(English)
Office	〒611-0011　京都府宇治市五ヶ庄	Gokasho, Uji, Kyoto 6110011, Japan

Phone

Type	Number
Office	0774-38-3225

Academic Degree

Field(Japanese)	Field(English)	University(Japanese)	University(English)	Method
修士（薬学）	M.S.	京都大学	Kyoto University
博士（薬学）	Ph.D	京都大学	Kyoto University

Personal Website(s) (URL(s))

URL
https://www.scl.kyoto-u.ac.jp/~uesugi/ja/index.php

ORCID ID

https://orcid.org/0000-0002-8515-445X

researchmap URL

https://researchmap.jp/read0122106

Research Topics

(Japanese)
ケミカルバイオロジー
(English)
Chemical Biology

Overview of the research

(Japanese)
ケミカルバイオロジーとは、化学を起点とした生物学です。生命の営みはせんじつめれば化学反応でできています。逆に化学を使って生命現象を理解したり、操ることができるはず。私たちの研究室では、生き物やヒト細胞にユニークな効果を及ぼす独自な有機化合物を見つける、もしくはデザインし、それらを道具として生命現象を探究・操作してきました。生物の仕組みは複雑ですが、有機化合物を起爆剤として用いることで、新たな切り口で生物を研究したり操作することができます。私たちの大きな研究目標は、生理活性合成化合物の新しい世界を切り開くことです。生理活性化合物の新しい利用法、新しいカタチをした生理活性化合物、新しいサイズの生理活性化合物など、アイデアを与えることができればと思うのです。こういったアイデアは、未来の創薬の考え方や化合物の細胞治療への利用などに結びつくはずです。
(English)
Chemical biology is an interdisciplinary field of study that is often defined as "chemistry-initiated biology." As biological processes all stem from chemical events, it should be possible to understand or manipulate biological events by using chemistry. Our laboratory has been discovering or designing unique organic molecules that modulate fundamental processes in human cells. Such synthetic organic molecules often serve as tools for basic cell biology. Discovery or design of small molecules with unique biological activity permits small-molecule initiated exploration of complex cellular events. Our mission is to create new world of bioactive synthetic molecules: their new way to use, their new shapes, and their new sizes. We hope to open new avenues for small-molecule applications in a range of fields, including future concepts in drug discovery and use of small molecules for cell therapy.

Fields of research (key words)

Key words(Japanese)	Key words(English)
ケミカルバイオロジー	Chemical Biology
生理活性小分子	Bioactive Small Molecules
化学プローブ	Chemical Probes
細胞治療	Cell Therapy
自己集合	Self-Assembly
化合物ライブラリー	Compound Library

Published Papers

Author	Author(Japanese)	Author(English)	Title	Title(Japanese)	Title(English)	Bibliography	Bibliography(Japanese)	Bibliography(English)	Publication date	Refereed paper	Language	Publishing type	Disclose
Takashima I, Kusamori K, Hakariya H, Takashima M, Vu TH, Mizukami Y, Noda N, Takayama Y, Katsuda Y, Sato SI, Takakura Y, Nishikawa M, Uesugi M	Takashima I, Kusamori K, Hakariya H, Takashima M, Vu TH, Mizukami Y, Noda N, Takayama Y, Katsuda Y, Sato SI, Takakura Y, Nishikawa M, Uesugi M	Takashima I, Kusamori K, Hakariya H, Takashima M, Vu TH, Mizukami Y, Noda N, Takayama Y, Katsuda Y, Sato SI, Takakura Y, Nishikawa M, Uesugi M	Multifunctionalization of Cells with a Self-Assembling Molecule to Enhance Cell Engraftment.	Multifunctionalization of Cells with a Self-Assembling Molecule to Enhance Cell Engraftment.	Multifunctionalization of Cells with a Self-Assembling Molecule to Enhance Cell Engraftment.	ACS chemical biology, 14, 4, 775-783	ACS chemical biology, 14, 4, 775-783	ACS chemical biology, 14, 4, 775-783	2019/04	Refereed			Disclose to all
Yatsuzuka K, Sato SI, Pe KB, Katsuda Y, Takashima I, Watanabe M, Uesugi M	Yatsuzuka K, Sato SI, Pe KB, Katsuda Y, Takashima I, Watanabe M, Uesugi M	Yatsuzuka K, Sato SI, Pe KB, Katsuda Y, Takashima I, Watanabe M, Uesugi M	Live-cell imaging of multiple endogenous mRNAs permits the direct observation of RNA granule dynamics.	Live-cell imaging of multiple endogenous mRNAs permits the direct observation of RNA granule dynamics.	Live-cell imaging of multiple endogenous mRNAs permits the direct observation of RNA granule dynamics.	Chemical communications (Cambridge, England), 54, 52, 7151-7154	Chemical communications (Cambridge, England), 54, 52, 7151-7154	Chemical communications (Cambridge, England), 54, 52, 7151-7154	2018/06	Refereed			Disclose to all
Perron A, Nishikawa Y, Iwata J, Shimojo H, Takaya J, Kobayashi K, Imayoshi I, Mbenza NM, Takenoya M, Kageyama R, Kodama Y, Uesugi M	Perron A, Nishikawa Y, Iwata J, Shimojo H, Takaya J, Kobayashi K, Imayoshi I, Mbenza NM, Takenoya M, Kageyama R, Kodama Y, Uesugi M	Perron A, Nishikawa Y, Iwata J, Shimojo H, Takaya J, Kobayashi K, Imayoshi I, Mbenza NM, Takenoya M, Kageyama R, Kodama Y, Uesugi M	Small-molecule screening yields a compound that inhibits the cancer-associated transcription factor Hes1 via the PHB2 chaperone.	Small-molecule screening yields a compound that inhibits the cancer-associated transcription factor Hes1 via the PHB2 chaperone.	Small-molecule screening yields a compound that inhibits the cancer-associated transcription factor Hes1 via the PHB2 chaperone.	The Journal of biological chemistry, 293, 21, 8285-8294	The Journal of biological chemistry, 293, 21, 8285-8294	The Journal of biological chemistry, 293, 21, 8285-8294	2018/05	Refereed			Disclose to all
Mao D, Chung XKW, Andoh-Noda T, Qin Y, Sato SI, Takemoto Y, Akamatsu W, Okano H, Uesugi M	Mao D, Chung XKW, Andoh-Noda T, Qin Y, Sato SI, Takemoto Y, Akamatsu W, Okano H, Uesugi M	Mao D, Chung XKW, Andoh-Noda T, Qin Y, Sato SI, Takemoto Y, Akamatsu W, Okano H, Uesugi M	Chemical decontamination of iPS cell-derived neural cell mixtures.	Chemical decontamination of iPS cell-derived neural cell mixtures.	Chemical decontamination of iPS cell-derived neural cell mixtures.	Chemical communications (Cambridge, England), 54, 11, 1355-1358	Chemical communications (Cambridge, England), 54, 11, 1355-1358	Chemical communications (Cambridge, England), 54, 11, 1355-1358	2018/02	Refereed			Disclose to all
Sato SI, Yatsuzuka K, Katsuda Y, Uesugi M	Sato SI, Yatsuzuka K, Katsuda Y, Uesugi M	Sato SI, Yatsuzuka K, Katsuda Y, Uesugi M	Method for Imaging Live-Cell RNA Using an RNA Aptamer and a Fluorescent Probe.	Method for Imaging Live-Cell RNA Using an RNA Aptamer and a Fluorescent Probe.	Method for Imaging Live-Cell RNA Using an RNA Aptamer and a Fluorescent Probe.	Methods in molecular biology (Clifton, N.J.), 1649, 305-318	Methods in molecular biology (Clifton, N.J.), 1649, 305-318	Methods in molecular biology (Clifton, N.J.), 1649, 305-318	2018	Refereed			Disclose to all
Asano L, Watanabe M, Ryoden Y, Usuda K, Yamaguchi T, Khambu B, Takashima M, Sato SI, Sakai J, Nagasawa K, Uesugi M	Asano L, Watanabe M, Ryoden Y, Usuda K, Yamaguchi T, Khambu B, Takashima M, Sato SI, Sakai J, Nagasawa K, Uesugi M	Asano L, Watanabe M, Ryoden Y, Usuda K, Yamaguchi T, Khambu B, Takashima M, Sato SI, Sakai J, Nagasawa K, Uesugi M	Vitamin D Metabolite, 25-Hydroxyvitamin D, Regulates Lipid Metabolism by Inducing Degradation of SREBP/SCAP.	Vitamin D Metabolite, 25-Hydroxyvitamin D, Regulates Lipid Metabolism by Inducing Degradation of SREBP/SCAP.	Vitamin D Metabolite, 25-Hydroxyvitamin D, Regulates Lipid Metabolism by Inducing Degradation of SREBP/SCAP.	Cell chemical biology, 24, 2, 207-217	Cell chemical biology, 24, 2, 207-217	Cell chemical biology, 24, 2, 207-217	2017/02	Refereed			Disclose to all
Mao D, Ando S, Sato SI, Qin Y, Hirata N, Katsuda Y, Kawase E, Kuo TF, Minami I, Shiba Y, Ueda K, Nakatsuji N, Uesugi M	Mao D, Ando S, Sato SI, Qin Y, Hirata N, Katsuda Y, Kawase E, Kuo TF, Minami I, Shiba Y, Ueda K, Nakatsuji N, Uesugi M	Mao D, Ando S, Sato SI, Qin Y, Hirata N, Katsuda Y, Kawase E, Kuo TF, Minami I, Shiba Y, Ueda K, Nakatsuji N, Uesugi M	A Synthetic Hybrid Molecule for the Selective Removal of Human Pluripotent Stem Cells from Cell Mixtures.	A Synthetic Hybrid Molecule for the Selective Removal of Human Pluripotent Stem Cells from Cell Mixtures.	A Synthetic Hybrid Molecule for the Selective Removal of Human Pluripotent Stem Cells from Cell Mixtures.	Angewandte Chemie (International ed. in English), 56, 7, 1765-1770	Angewandte Chemie (International ed. in English), 56, 7, 1765-1770	Angewandte Chemie (International ed. in English), 56, 7, 1765-1770	2017/02	Refereed			Disclose to all
Katsuda Y, Sato SI, Asano L, Morimura Y, Furuta T, Sugiyama H, Hagihara M, Uesugi M	Katsuda Y, Sato SI, Asano L, Morimura Y, Furuta T, Sugiyama H, Hagihara M, Uesugi M	Katsuda Y, Sato SI, Asano L, Morimura Y, Furuta T, Sugiyama H, Hagihara M, Uesugi M	A Small Molecule That Represses Translation of G-Quadruplex-Containing mRNA.	A Small Molecule That Represses Translation of G-Quadruplex-Containing mRNA.	A Small Molecule That Represses Translation of G-Quadruplex-Containing mRNA.	Journal of the American Chemical Society, 138, 29, 9037-9040	Journal of the American Chemical Society, 138, 29, 9037-9040	Journal of the American Chemical Society, 138, 29, 9037-9040	2016/07	Refereed	English		Disclose to all
Takaya J, Mio K, Shiraishi T, Kurokawa T, Otsuka S, Mori Y, Uesugi M	Takaya J, Mio K, Shiraishi T, Kurokawa T, Otsuka S, Mori Y, Uesugi M	Takaya J, Mio K, Shiraishi T, Kurokawa T, Otsuka S, Mori Y, Uesugi M	A Potent and Site-Selective Agonist of TRPA1.	A Potent and Site-Selective Agonist of TRPA1.	A Potent and Site-Selective Agonist of TRPA1.	Journal of the American Chemical Society, 137, 50, 15859-15864	Journal of the American Chemical Society, 137, 50, 15859-15864	Journal of the American Chemical Society, 137, 50, 15859-15864	2015/12	Refereed	English		Disclose to all
Sato S, Watanabe M, Katsuda Y, Murata A, Wang DO, Uesugi M	Sato S, Watanabe M, Katsuda Y, Murata A, Wang DO, Uesugi M	Sato S, Watanabe M, Katsuda Y, Murata A, Wang DO, Uesugi M	Live-cell imaging of endogenous mRNAs with a small molecule.	Live-cell imaging of endogenous mRNAs with a small molecule.	Live-cell imaging of endogenous mRNAs with a small molecule.	Angewandte Chemie (International ed. in English), 54, 6, 1855-1858	Angewandte Chemie (International ed. in English), 54, 6, 1855-1858	Angewandte Chemie (International ed. in English), 54, 6, 1855-1858	2015/02	Refereed	English		Disclose to all
Frisco-Cabanos HL, Watanabe M, Okumura N, Kusamori K, Takemoto N, Takaya J, Sato S, Yamazoe S, Takakura Y, Kinoshita S, Nishikawa M, Koizumi N, Uesugi M	Frisco-Cabanos HL, Watanabe M, Okumura N, Kusamori K, Takemoto N, Takaya J, Sato S, Yamazoe S, Takakura Y, Kinoshita S, Nishikawa M, Koizumi N, Uesugi M	Frisco-Cabanos HL, Watanabe M, Okumura N, Kusamori K, Takemoto N, Takaya J, Sato S, Yamazoe S, Takakura Y, Kinoshita S, Nishikawa M, Koizumi N, Uesugi M	Synthetic molecules that protect cells from anoikis and their use in cell transplantation.	Synthetic molecules that protect cells from anoikis and their use in cell transplantation.	Synthetic molecules that protect cells from anoikis and their use in cell transplantation.	Angewandte Chemie (International ed. in English), 53, 42, 11208-11213	Angewandte Chemie (International ed. in English), 53, 42, 11208-11213	Angewandte Chemie (International ed. in English), 53, 42, 11208-11213	2014/10	Refereed	English		Disclose to all
Kuo TF, Mao D, Hirata N, Khambu B, Kimura Y, Kawase E, Shimogawa H, Ojika M, Nakatsuji N, Ueda K, Uesugi M	Kuo TF, Mao D, Hirata N, Khambu B, Kimura Y, Kawase E, Shimogawa H, Ojika M, Nakatsuji N, Ueda K, Uesugi M	Kuo TF, Mao D, Hirata N, Khambu B, Kimura Y, Kawase E, Shimogawa H, Ojika M, Nakatsuji N, Ueda K, Uesugi M	Selective elimination of human pluripotent stem cells by a marine natural product derivative.	Selective elimination of human pluripotent stem cells by a marine natural product derivative.	Selective elimination of human pluripotent stem cells by a marine natural product derivative.	Journal of the American Chemical Society, 136, 28, 9798-9801	Journal of the American Chemical Society, 136, 28, 9798-9801	Journal of the American Chemical Society, 136, 28, 9798-9801	2014/07	Refereed	English		Disclose to all
Hirata N, Nakagawa M, Fujibayashi Y, Yamauchi K, Murata A, Minami I, Tomioka M, Kondo T, Kuo TF, Endo H, Inoue H, Sato S, Ando S, Kawazoe Y, Aiba K, Nagata K, Kawase E, Chang YT, Suemori H, Eto K, Nakauchi H, Yamanaka S, Nakatsuji N, Ueda K, Uesugi M	Hirata N, Nakagawa M, Fujibayashi Y, Yamauchi K, Murata A, Minami I, Tomioka M, Kondo T, Kuo TF, Endo H, Inoue H, Sato S, Ando S, Kawazoe Y, Aiba K, Nagata K, Kawase E, Chang YT, Suemori H, Eto K, Nakauchi H, Yamanaka S, Nakatsuji N, Ueda K, Uesugi M	Hirata N, Nakagawa M, Fujibayashi Y, Yamauchi K, Murata A, Minami I, Tomioka M, Kondo T, Kuo TF, Endo H, Inoue H, Sato S, Ando S, Kawazoe Y, Aiba K, Nagata K, Kawase E, Chang YT, Suemori H, Eto K, Nakauchi H, Yamanaka S, Nakatsuji N, Ueda K, Uesugi M	A chemical probe that labels human pluripotent stem cells.	A chemical probe that labels human pluripotent stem cells.	A chemical probe that labels human pluripotent stem cells.	Cell reports, 6, 6, 1165-1174	Cell reports, 6, 6, 1165-1174	Cell reports, 6, 6, 1165-1174	2014/03	Refereed	English		Disclose to all
Sakano D, Shiraki N, Kikawa K, Yamazoe T, Kataoka M, Umeda K, Araki K, Mao D, Matsumoto S, Nakagata N, Andersson O, Stainier D, Endo F, Kume K, Uesugi M, Kume S	Sakano D, Shiraki N, Kikawa K, Yamazoe T, Kataoka M, Umeda K, Araki K, Mao D, Matsumoto S, Nakagata N, Andersson O, Stainier D, Endo F, Kume K, Uesugi M, Kume S	Sakano D, Shiraki N, Kikawa K, Yamazoe T, Kataoka M, Umeda K, Araki K, Mao D, Matsumoto S, Nakagata N, Andersson O, Stainier D, Endo F, Kume K, Uesugi M, Kume S	VMAT2 identified as a regulator of late-stage β-cell differentiation.	VMAT2 identified as a regulator of late-stage β-cell differentiation.	VMAT2 identified as a regulator of late-stage β-cell differentiation.	Nature chemical biology, 10, 2, 141-148	Nature chemical biology, 10, 2, 141-148	Nature chemical biology, 10, 2, 141-148	2014/02	Refereed	English		Disclose to all
Takemoto, N.; Suehara, T.; Frisco, H.; Sato, S.; Sezaki, T.; Kusamori, K.; Kawazoe, Y.; Park, S.M.; Yamazoe, S.; Mizuhata, Y.; Inoue, R.; Miller, G.; Hansen, S.; Jayson, G.; Gardiner, J.; Kanaya, T.; Tokitoh, N.; Ueda, K.; Takakura, Y.; Kioka, N.; Nishikawa, M.; Uesugi, M.	Takemoto, N.; Suehara, T.; Frisco, H.; Sato, S.; Sezaki, T.; Kusamori, K.; Kawazoe, Y.; Park, S.M.; Yamazoe, S.; Mizuhata, Y.; Inoue, R.; Miller, G.; Hansen, S.; Jayson, G.; Gardiner, J.; Kanaya, T.; Tokitoh, N.; Ueda, K.; Takakura, Y.; Kioka, N.; Nishikawa, M.; Uesugi, M.	Takemoto, N.; Suehara, T.; Frisco, H.; Sato, S.; Sezaki, T.; Kusamori, K.; Kawazoe, Y.; Park, S.M.; Yamazoe, S.; Mizuhata, Y.; Inoue, R.; Miller, G.; Hansen, S.; Jayson, G.; Gardiner, J.; Kanaya, T.; Tokitoh, N.; Ueda, K.; Takakura, Y.; Kioka, N.; Nishikawa, M.; Uesugi, M.	Small Molecule-induced Clustering of Heparan Sulfate Promotes Cell Adhesion.	Small Molecule-induced Clustering of Heparan Sulfate Promotes Cell Adhesion.	Small Molecule-induced Clustering of Heparan Sulfate Promotes Cell Adhesion.	J. Am. Chem. Soc., 135, 30, 11032-11039	J. Am. Chem. Soc., 135, 30, 11032-11039	J. Am. Chem. Soc., 135, 30, 11032-11039	2013/07	Refereed	English	Research paper(scientific journal)	Disclose to all
D. Jung; L. Abu-Elheiga; R. Ayuzawa; Z. Gu; T. Shirakawa; Y. Fujiki; N. Nakatsuji; S.J. Wakil; M. Uesugi	Jung D, Abu-Elheiga L, Ayuzawa R, Gu Z, Shirakawa T, Fujiki Y, Nakatsuji N, Wakil SJ, Uesugi M	D. Jung; L. Abu-Elheiga; R. Ayuzawa; Z. Gu; T. Shirakawa; Y. Fujiki; N. Nakatsuji; S.J. Wakil; M. Uesugi	Mislocalization and inhibition of acetyl-CoA carboxylase 1 by a synthetic small molecule	Mislocalization and inhibition of acetyl-CoA carboxylase 1 by a synthetic small molecule.	Mislocalization and inhibition of acetyl-CoA carboxylase 1 by a synthetic small molecule	Biochemical Journal, 448, 3, 409-416	The Biochemical journal, 448, 3, 409-416	Biochemical Journal, 448, 3, 409-416	2012/12	Refereed	English		Disclose to all
I. Minami; K. Yamada; T.G. Otsuji; T. Yamamoto; Y. Shen; S. Otsuka; S. Kadota; N. Morone; M. Barve; Y. Asai; T. Tenkova-Heuser; J.E. Heuser; M. Uesugi; K. Aiba; N. Nakatsuji	Minami I, Yamada K, Otsuji TG, Yamamoto T, Shen Y, Otsuka S, Kadota S, Morone N, Barve M, Asai Y, Tenkova-Heuser T, Heuser JE, Uesugi M, Aiba K, Nakatsuji N	I. Minami; K. Yamada; T.G. Otsuji; T. Yamamoto; Y. Shen; S. Otsuka; S. Kadota; N. Morone; M. Barve; Y. Asai; T. Tenkova-Heuser; J.E. Heuser; M. Uesugi; K. Aiba; N. Nakatsuji	A Small Molecule that Promotes Cardiac Differentiation of Human Pluripotent Stem Cells under Defined, Cytokine- and Xeno-free Conditions	A small molecule that promotes cardiac differentiation of human pluripotent stem cells under defined, cytokine- and xeno-free conditions.	A Small Molecule that Promotes Cardiac Differentiation of Human Pluripotent Stem Cells under Defined, Cytokine- and Xeno-free Conditions	Cell Reports, 2, 5, 1448-1460	Cell reports, 2, 5, 1448-1460	Cell Reports, 2, 5, 1448-1460	2012/11	Refereed	English		Disclose to all
Uesugi M	Uesugi M	Uesugi M	[Control and analysis of cells by synthetic small molecules].	[Control and analysis of cells by synthetic small molecules].	[Control and analysis of cells by synthetic small molecules].	Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan, 132, 5, 575-586	Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan, 132, 5, 575-586	Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan, 132, 5, 575-586	2012	Refereed			Disclose to all
Khambu, Bilon; Uesugi, Motonari; Kawazoe, Yoshinori	Khambu B, Uesugi M, Kawazoe Y	Khambu, Bilon; Uesugi, Motonari; Kawazoe, Yoshinori	Translational repression stabilizes messenger RNA of autophagy-related genes	Translational repression stabilizes messenger RNA of autophagy-related genes.	Translational repression stabilizes messenger RNA of autophagy-related genes	GENES TO CELLS, 16, 8, 857-867	Genes to cells : devoted to molecular & cellular mechanisms, 16, 8, 857-867	GENES TO CELLS, 16, 8, 857-867	2011/08	Refereed	English		Disclose to all
S. Kamisuki; T. Shirakawa; A. Kugimiya; L. Abu-Elheiga; H.-Y. Park Choo; K. Yamada; H. Shimogawa; S.J. Wakil; M. Uesugi	Kamisuki S, Shirakawa T, Kugimiya A, Abu-Elheiga L, Choo HY, Yamada K, Shimogawa H, Wakil SJ, Uesugi M	S. Kamisuki; T. Shirakawa; A. Kugimiya; L. Abu-Elheiga; H.-Y. Park Choo; K. Yamada; H. Shimogawa; S.J. Wakil; M. Uesugi	Synthesis and evaluation of diarylthiazole derivatives that inhibit activation of sterol regulatory element-binding proteins	Synthesis and evaluation of diarylthiazole derivatives that inhibit activation of sterol regulatory element-binding proteins.	Synthesis and evaluation of diarylthiazole derivatives that inhibit activation of sterol regulatory element-binding proteins	Journal of Medicinal Chemistry, 54, 13, 4923-4927	Journal of medicinal chemistry, 54, 13, 4923-4927	Journal of Medicinal Chemistry, 54, 13, 4923-4927	2011/07	Refereed	English		Disclose to all
Y. Kawazoe; H. Shimogawa; A. Sato; M. Uesugi	Kawazoe Y, Shimogawa H, Sato A, Uesugi M	Y. Kawazoe; H. Shimogawa; A. Sato; M. Uesugi	A mitochondrial surface-specific fluorescent probe activated by bioconversion	A mitochondrial surface-specific fluorescent probe activated by bioconversion.	A mitochondrial surface-specific fluorescent probe activated by bioconversion	Angewandte Chemie - International Edition, 50, 24, 5478-5481	Angewandte Chemie (International ed. in English), 50, 24, 5478-5481	Angewandte Chemie - International Edition, 50, 24, 5478-5481	2011/06	Refereed	English		Disclose to all
E. Sumiya; H. Shimogawa; H. Sasaki; M. Tsutsumi; K. Yoshita; M. Ojika; K. Suenaga; M. Uesugi	Sumiya E, Shimogawa H, Sasaki H, Tsutsumi M, Yoshita K, Ojika M, Suenaga K, Uesugi M	E. Sumiya; H. Shimogawa; H. Sasaki; M. Tsutsumi; K. Yoshita; M. Ojika; K. Suenaga; M. Uesugi	Cell-morphology profiling of a natural product library identifies bisebromoamide and miuraenamide A as actin filament stabilizers	Cell-morphology profiling of a natural product library identifies bisebromoamide and miuraenamide A as actin filament stabilizers.	Cell-morphology profiling of a natural product library identifies bisebromoamide and miuraenamide A as actin filament stabilizers	ACS Chemical Biology, 6, 5, 425-431	ACS chemical biology, 6, 5, 425-431	ACS Chemical Biology, 6, 5, 425-431	2011/05	Refereed	English		Disclose to all
A. Murata; S.-I. Sato; Y. Kawazoe; M. Uesugi	Murata A, Sato S, Kawazoe Y, Uesugi M	A. Murata; S.-I. Sato; Y. Kawazoe; M. Uesugi	Small-molecule fluorescent probes for specific RNA targets	Small-molecule fluorescent probes for specific RNA targets.	Small-molecule fluorescent probes for specific RNA targets	Chemical Communications, 47, 16, 4712-4714	Chemical communications (Cambridge, England), 47, 16, 4712-4714	Chemical Communications, 47, 16, 4712-4714	2011/04	Refereed	English		Disclose to all
T. Shirakawa; Y. Kawazoe; T. Tsujikawa; D. Jung; S.-I. Sato; M. Uesugi	Shirakawa T, Kawazoe Y, Tsujikawa T, Jung D, Sato S, Uesugi M	T. Shirakawa; Y. Kawazoe; T. Tsujikawa; D. Jung; S.-I. Sato; M. Uesugi	Deactivation of STAT6 through serine 707 phosphorylation by JNK	Deactivation of STAT6 through serine 707 phosphorylation by JNK.	Deactivation of STAT6 through serine 707 phosphorylation by JNK	Journal of Biological Chemistry, 286, 5, 4003-4010	The Journal of biological chemistry, 286, 5, 4003-4010	Journal of Biological Chemistry, 286, 5, 4003-4010	2011/02	Refereed	English		Disclose to all
S.-I. Sato; A. Murata; T. Orihara; T. Shirakawa; K. Suenaga; H. Kigoshi; M. Uesugi	Sato S, Murata A, Orihara T, Shirakawa T, Suenaga K, Kigoshi H, Uesugi M	S.-I. Sato; A. Murata; T. Orihara; T. Shirakawa; K. Suenaga; H. Kigoshi; M. Uesugi	Marine natural product aurilide activates the opa1-mediated apoptosis by binding to prohibitin	Marine natural product aurilide activates the OPA1-mediated apoptosis by binding to prohibitin.	Marine natural product aurilide activates the opa1-mediated apoptosis by binding to prohibitin	Chemistry and Biology, 18, 1, 131-139	Chemistry & biology, 18, 1, 131-139	Chemistry and Biology, 18, 1, 131-139	2011/01	Refereed	English		Disclose to all
R. Murai; Y. Yoshida; T. Muraguchi; E. Nishimoto; Y. Morioka; H. Kitayama; S. Kondoh; Y. Kawazoe; M. Hiraoka; M. Uesugi; M. Noda	Murai R, Yoshida Y, Muraguchi T, Nishimoto E, Morioka Y, Kitayama H, Kondoh S, Kawazoe Y, Hiraoka M, Uesugi M, Noda M	R. Murai; Y. Yoshida; T. Muraguchi; E. Nishimoto; Y. Morioka; H. Kitayama; S. Kondoh; Y. Kawazoe; M. Hiraoka; M. Uesugi; M. Noda	A novel screen using the Reck tumor suppressor gene promoter detects both conventional and metastasis-suppressing anticancer drugs.	A novel screen using the Reck tumor suppressor gene promoter detects both conventional and metastasis-suppressing anticancer drugs.	A novel screen using the Reck tumor suppressor gene promoter detects both conventional and metastasis-suppressing anticancer drugs.	Oncotarget, 1, 4, 252-264	Oncotarget, 1, 4, 252-264	Oncotarget, 1, 4, 252-264	2010/08	Refereed	English		Disclose to all
S.-i. Sato; A. Murata; T. Shirakawa; M. Uesugi	Sato S, Murata A, Shirakawa T, Uesugi M	S.-i. Sato; A. Murata; T. Shirakawa; M. Uesugi	Biochemical Target Isolation for Novices: Affinity-Based Strategies	Biochemical target isolation for novices: affinity-based strategies.	Biochemical Target Isolation for Novices: Affinity-Based Strategies	Chemistry and Biology, 17, 6, 616-623	Chemistry & biology, 17, 6, 616-623	Chemistry and Biology, 17, 6, 616-623	2010/06	Refereed	English		Disclose to all
S. Kamisuki; Q. Mao; L. Abu-Elheiga; Z. Gu; A. Kugimiya; Y. Kwon; T. Shinohara; Y. Kawazoe; S.-i. Sato; K. Asakura; H.-Y.P. Choo; J. Sakai; S.J. Wakil; M. Uesugi	Kamisuki S, Mao Q, Abu-Elheiga L, Gu Z, Kugimiya A, Kwon Y, Shinohara T, Kawazoe Y, Sato S, Asakura K, Choo HY, Sakai J, Wakil SJ, Uesugi M	S. Kamisuki; Q. Mao; L. Abu-Elheiga; Z. Gu; A. Kugimiya; Y. Kwon; T. Shinohara; Y. Kawazoe; S.-i. Sato; K. Asakura; H.-Y.P. Choo; J. Sakai; S.J. Wakil; M. Uesugi	A Small Molecule That Blocks Fat Synthesis By Inhibiting the Activation of SREBP	A small molecule that blocks fat synthesis by inhibiting the activation of SREBP.	A Small Molecule That Blocks Fat Synthesis By Inhibiting the Activation of SREBP	Chemistry and Biology, 16, 8, 882-892	Chemistry & biology, 16, 8, 882-892	Chemistry and Biology, 16, 8, 882-892	2009/08	Refereed	English		Disclose to all
S. Yamazoe; H. Shimogawa; S.-i. Sato; J.D. Esko; M. Uesugi	Yamazoe S, Shimogawa H, Sato S, Esko JD, Uesugi M	S. Yamazoe; H. Shimogawa; S.-i. Sato; J.D. Esko; M. Uesugi	A Dumbbell-Shaped Small Molecule that Promotes Cell Adhesion and Growth	A dumbbell-shaped small molecule that promotes cell adhesion and growth.	A Dumbbell-Shaped Small Molecule that Promotes Cell Adhesion and Growth	Chemistry and Biology, 16, 7, 773-782	Chemistry & biology, 16, 7, 773-782	Chemistry and Biology, 16, 7, 773-782	2009/07	Refereed	English		Disclose to all
D. Jung; H. Shimogawa; Y. Kwon; Q. Mao; S.-I. Sato; S. Kamisuki; H. Kigoshi; M. Uesugi	Jung D, Shimogawa H, Kwon Y, Mao Q, Sato S, Kamisuki S, Kigoshi H, Uesugi M	D. Jung; H. Shimogawa; Y. Kwon; Q. Mao; S.-I. Sato; S. Kamisuki; H. Kigoshi; M. Uesugi	Wrenchnolol derivative optimized for gene activation in cells	Wrenchnolol derivative optimized for gene activation in cells.	Wrenchnolol derivative optimized for gene activation in cells	Journal of the American Chemical Society, 131, 13, 4774-4782	Journal of the American Chemical Society, 131, 13, 4774-4782	Journal of the American Chemical Society, 131, 13, 4774-4782	2009/04	Refereed	English		Disclose to all
Kamisuki S, Uesugi M	Kamisuki S, Uesugi M	Kamisuki S, Uesugi M	[Discovering high-affinity ligands for proteins: SAR by NMR].	[Discovering high-affinity ligands for proteins: SAR by NMR].	[Discovering high-affinity ligands for proteins: SAR by NMR].	Tanpakushitsu kakusan koso. Protein, nucleic acid, enzyme, 52, 13 Suppl, 1818-1819	Tanpakushitsu kakusan koso. Protein, nucleic acid, enzyme, 52, 13 Suppl, 1818-1819	Tanpakushitsu kakusan koso. Protein, nucleic acid, enzyme, 52, 13 Suppl, 1818-1819	2007/10	Refereed			Disclose to all
Shinohara T, Uesugi M	Shinohara T, Uesugi M	Shinohara T, Uesugi M	[In-vivo activation of the p53 pathway by small-molecule antagonists of MDM2].	[In-vivo activation of the p53 pathway by small-molecule antagonists of MDM2].	[In-vivo activation of the p53 pathway by small-molecule antagonists of MDM2].	Tanpakushitsu kakusan koso. Protein, nucleic acid, enzyme, 52, 13 Suppl, 1816-1817	Tanpakushitsu kakusan koso. Protein, nucleic acid, enzyme, 52, 13 Suppl, 1816-1817	Tanpakushitsu kakusan koso. Protein, nucleic acid, enzyme, 52, 13 Suppl, 1816-1817	2007/10	Refereed			Disclose to all
Kugimiya A, Takagi J, Uesugi M	Kugimiya A, Takagi J, Uesugi M	Kugimiya A, Takagi J, Uesugi M	[Role of LXRs in control of lipogenesis].	[Role of LXRs in control of lipogenesis].	[Role of LXRs in control of lipogenesis].	Tanpakushitsu kakusan koso. Protein, nucleic acid, enzyme, 52, 13 Suppl, 1814-1815	Tanpakushitsu kakusan koso. Protein, nucleic acid, enzyme, 52, 13 Suppl, 1814-1815	Tanpakushitsu kakusan koso. Protein, nucleic acid, enzyme, 52, 13 Suppl, 1814-1815	2007/10	Refereed			Disclose to all
Sato S, Murata A, Uesugi M	Sato S, Murata A, Uesugi M	Sato S, Murata A, Uesugi M	[Identification of the cardiac beta-adrenergic receptor protein: solubilization and purification by affinity chromatography].	[Identification of the cardiac beta-adrenergic receptor protein: solubilization and purification by affinity chromatography].	[Identification of the cardiac beta-adrenergic receptor protein: solubilization and purification by affinity chromatography].	Tanpakushitsu kakusan koso. Protein, nucleic acid, enzyme, 52, 13 Suppl, 1782-1783	Tanpakushitsu kakusan koso. Protein, nucleic acid, enzyme, 52, 13 Suppl, 1782-1783	Tanpakushitsu kakusan koso. Protein, nucleic acid, enzyme, 52, 13 Suppl, 1782-1783	2007/10	Refereed			Disclose to all
S.-I. Sato; Y. Kwon; S. Kamisuki; N. Srivastava; Q. Mao; Y. Kawazoe; M. Uesugi	Sato S, Kwon Y, Kamisuki S, Srivastava N, Mao Q, Kawazoe Y, Uesugi M	S.-I. Sato; Y. Kwon; S. Kamisuki; N. Srivastava; Q. Mao; Y. Kawazoe; M. Uesugi	Polyproline-rod approach to isolating protein targets of bioactive small molecules: Isolation of a new target of indomethacin	Polyproline-rod approach to isolating protein targets of bioactive small molecules: isolation of a new target of indomethacin.	Polyproline-rod approach to isolating protein targets of bioactive small molecules: Isolation of a new target of indomethacin	Journal of the American Chemical Society, 129, 4, 873-880	Journal of the American Chemical Society, 129, 4, 873-880	Journal of the American Chemical Society, 129, 4, 873-880	2007/01	Refereed	English		Disclose to all
Jung, DJ; Choi, YM; Uesugi, M	Jung D, Choi Y, Uesugi M	Jung, DJ; Choi, YM; Uesugi, M	Small organic molecules that modulate gene transcription	Small organic molecules that modulate gene transcription.	Small organic molecules that modulate gene transcription	DRUG DISCOVERY TODAY, 11, 9-10, 452-457	Drug discovery today, 11, 9-10, 452-457	DRUG DISCOVERY TODAY, 11, 9-10, 452-457	2006/05	Refereed	English		Disclose to all
Y. Choi; H. Shimogawa; K. Murakami; L. Ramdas; W. Zhang; J. Qin; M. Uesugi	Choi Y, Shimogawa H, Murakami K, Ramdas L, Zhang W, Qin J, Uesugi M	Y. Choi; H. Shimogawa; K. Murakami; L. Ramdas; W. Zhang; J. Qin; M. Uesugi	Chemical Genetic Identification of the IGF-Linked Pathway that Is Mediated by STAT6 and MFP2	Chemical genetic identification of the IGF-linked pathway that is mediated by STAT6 and MFP2.	Chemical Genetic Identification of the IGF-Linked Pathway that Is Mediated by STAT6 and MFP2	Chemistry and Biology, 13, 3, 241-249	Chemistry & biology, 13, 3, 241-249	Chemistry and Biology, 13, 3, 241-249	2006/03	Refereed	English		Disclose to all
Uesugi M	Uesugi M	Uesugi M	[Small molecules that control gene expression].	[Small molecules that control gene expression].	[Small molecules that control gene expression].	Seikagaku. The Journal of Japanese Biochemical Society, 77, 9, 1177-1180	Seikagaku. The Journal of Japanese Biochemical Society, 77, 9, 1177-1180	Seikagaku. The Journal of Japanese Biochemical Society, 77, 9, 1177-1180	2005/09	Refereed			Disclose to all
Kawazoe Y, Uesugi M	Kawazoe Y, Uesugi M	Kawazoe Y, Uesugi M	[Trends in chemical libraries for chemical genetics].	[Trends in chemical libraries for chemical genetics].	[Trends in chemical libraries for chemical genetics].	Tanpakushitsu kakusan koso. Protein, nucleic acid, enzyme, 50, 9, 1043-1048	Tanpakushitsu kakusan koso. Protein, nucleic acid, enzyme, 50, 9, 1043-1048	Tanpakushitsu kakusan koso. Protein, nucleic acid, enzyme, 50, 9, 1043-1048	2005/08	Refereed			Disclose to all
Kwonj, Y; Arndt, HD; Qian, M; Choi, Y; Kawazoe, Y; Dervan, PB; Uesugi, M	Kwon Y, Arndt HD, Mao Q, Choi Y, Kawazoe Y, Dervan PB, Uesugi M	Kwonj, Y; Arndt, HD; Qian, M; Choi, Y; Kawazoe, Y; Dervan, PB; Uesugi, M	Small molecule transcription factor mimic	Small molecule transcription factor mimic.	Small molecule transcription factor mimic	JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 126, 49, 15940-15941	Journal of the American Chemical Society, 126, 49, 15940-15941	JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 126, 49, 15940-15941	2004/12	Refereed	English		Disclose to all
Uesugi, M	Uesugi M	Uesugi, M	Synthetic molecules that modulate transcription and differentiation: Hints for future drug discovery	Synthetic molecules that modulate transcription and differentiation: hints for future drug discovery.	Synthetic molecules that modulate transcription and differentiation: Hints for future drug discovery	COMBINATORIAL CHEMISTRY & HIGH THROUGHPUT SCREENING, 7, 7, 653-659	Combinatorial chemistry & high throughput screening, 7, 7, 653-659	COMBINATORIAL CHEMISTRY & HIGH THROUGHPUT SCREENING, 7, 7, 653-659	2004/11	Refereed	English		Disclose to all
Kawazoe, Y., Tanaka, H., Uesugi, M.	Kawazoe Y, Tanaka S, Uesugi M	Kawazoe, Y., Tanaka, H., Uesugi, M.	Chemical genetic identification of histamine receptor H1 as a stimulator of insulin-induced adipogenesis	Chemical genetic identification of the histamine H1 receptor as a stimulator of insulin-induced adipogenesis.	Chemical genetic identification of histamine receptor H1 as a stimulator of insulin-induced adipogenesis	Chem. Biol. 11, 907-913, 11, 7, 907-913	Chemistry & biology, 11, 7, 907-913	Chem. Biol. 11, 907-913, 11, 7, 907-913	2004/07	Refereed	English		Disclose to all
H. Shimogawa; Y. Kwon; Q. Mao; Y. Kawazoe; Y. Choi; S. Asada; H. Kigoshi; M. Uesugi	Shimogawa H, Kwon Y, Mao Q, Kawazoe Y, Choi Y, Asada S, Kigoshi H, Uesugi M	H. Shimogawa; Y. Kwon; Q. Mao; Y. Kawazoe; Y. Choi; S. Asada; H. Kigoshi; M. Uesugi	A Wrench-Shaped Synthetic Molecule that Modulates a Transcription Factor-Coactivator Interaction	A wrench-shaped synthetic molecule that modulates a transcription factor-coactivator interaction.	A Wrench-Shaped Synthetic Molecule that Modulates a Transcription Factor-Coactivator Interaction	Journal of the American Chemical Society, 126, 11, 3461-3471	Journal of the American Chemical Society, 126, 11, 3461-3471	Journal of the American Chemical Society, 126, 11, 3461-3471	2004/03	Refereed	English		Disclose to all
Asada, S; Choi, YM; Uesugi, M	Asada S, Choi Y, Uesugi M	Asada, S; Choi, YM; Uesugi, M	A gene-expression inhibitor that targets an alpha-helix-mediated protein interaction	A gene-expression inhibitor that targets an alpha-helix-mediated protein interaction.	A gene-expression inhibitor that targets an alpha-helix-mediated protein interaction	JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 125, 17, 4992-4993	Journal of the American Chemical Society, 125, 17, 4992-4993	JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 125, 17, 4992-4993	2003/04	Refereed	English		Disclose to all
Choi, YM; Kawazoe, Y; Murakami, K; Misawa, H; Uesugi, M	Choi Y, Kawazoe Y, Murakami K, Misawa H, Uesugi M	Choi, YM; Kawazoe, Y; Murakami, K; Misawa, H; Uesugi, M	Identification of bioactive molecules by adipogenesis profiling of organic compounds	Identification of bioactive molecules by adipogenesis profiling of organic compounds.	Identification of bioactive molecules by adipogenesis profiling of organic compounds	JOURNAL OF BIOLOGICAL CHEMISTRY, 278, 9, 7320-7324	The Journal of biological chemistry, 278, 9, 7320-7324	JOURNAL OF BIOLOGICAL CHEMISTRY, 278, 9, 7320-7324	2003/02	Refereed	English		Disclose to all
Jabbur J. R., Tabor, A. D., Cheng, X., Wang, H., Uesugi, M., Lozano, G., Zhang, W.	Jabbur JR, Tabor AD, Cheng X, Wang H, Uesugi M, Lozano G, Zhang W	Jabbur J. R., Tabor, A. D., Cheng, X., Wang, H., Uesugi, M., Lozano, G., Zhang, W.	Phosphorylation at threonine 18 of p53 alters hydrogen bonding attenuating mdm2 binding and TAFII31 recruitment	Mdm-2 binding and TAF(II)31 recruitment is regulated by hydrogen bond disruption between the p53 residues Thr18 and Asp21.	Phosphorylation at threonine 18 of p53 alters hydrogen bonding attenuating mdm2 binding and TAFII31 recruitment	Oncogene 21, 7100-7113, 21, 46, 7100-7113	Oncogene, 21, 46, 7100-7113	Oncogene 21, 7100-7113, 21, 46, 7100-7113	2002/10	Refereed	English		Disclose to all
Suzuki, Takayoshi; Arai, Midori A.; Nakashima, Mitsue; Uesugi, Motonari		Suzuki, Takayoshi; Arai, Midori A.; Nakashima, Mitsue; Uesugi, Motonari	Merging Chemistry and Biology in Emerging Countries		Merging Chemistry and Biology in Emerging Countries	CHEMISTRY & BIOLOGY, 20, 4, 461-465	, 20, 4, 461-465	CHEMISTRY & BIOLOGY, 20, 4, 461-465	2013/04/18	Refereed	English		Disclose to all
T. Morii; M. Uesugi		T. Morii; M. Uesugi	Two days of experiments in Vietnam: Asian chemical biology initiative, Hanoi meeting		Two days of experiments in Vietnam: Asian chemical biology initiative, Hanoi meeting	ACS Chemical Biology, 7, 4, 623-625	, 7, 4, 623-625	ACS Chemical Biology, 7, 4, 623-625	2012/04	Refereed	English		Disclose to all
Henderson YC, Frederick MJ, Jayakumar A, Choi Y, Wang MT, Kang Y, Evans R, Spring PM, Uesugi M, Clayman GL		Henderson YC, Frederick MJ, Jayakumar A, Choi Y, Wang MT, Kang Y, Evans R, Spring PM, Uesugi M, Clayman GL	Human LBP-32/MGR is a repressor of the P450scc in human choriocarcinoma cell line JEG-3.		Human LBP-32/MGR is a repressor of the P450scc in human choriocarcinoma cell line JEG-3.	Placenta 28(2-3), 152-160		Placenta 28(2-3), 152-160	2006		English		Disclose to all
Choi, Y., Uesugi, M.		Choi, Y., Uesugi, M.	Regulation of IGF2 functions by a bioactive small molecule		Regulation of IGF2 functions by a bioactive small molecule	FASEB Journal, 18, C219-C219		FASEB Journal, 18, C219-C219	2004		English		Disclose to all
Skowyra, D., Zeremski, M., Neznanov, N., Li, M., Choi, Y., Uesugi, M., Hauser, C. A., Gu, W., Gudkov, A. V., Qin, J.		Skowyra, D., Zeremski, M., Neznanov, N., Li, M., Choi, Y., Uesugi, M., Hauser, C. A., Gu, W., Gudkov, A. V., Qin, J.	Differential Association of Products of Alternative Transcripts of the Candidate Tumor Suppressor ING1 with the mSin3/HDAC1 Transcriptional Corepressor Complex		Differential Association of Products of Alternative Transcripts of the Candidate Tumor Suppressor ING1 with the mSin3/HDAC1 Transcriptional Corepressor Complex	J. Biol. Chem. 276, 8713-8719		J. Biol. Chem. 276, 8713-8719	2001	Refereed	English		Disclose to all
Choi, Y; Asada, S; Uesugi, M		Choi, Y; Asada, S; Uesugi, M	Divergent hTAF(II)31-binding motifs hidden in activation domains		Divergent hTAF(II)31-binding motifs hidden in activation domains	JOURNAL OF BIOLOGICAL CHEMISTRY, 275, 21, 15912-15916	, 275, 21, 15912-15916	JOURNAL OF BIOLOGICAL CHEMISTRY, 275, 21, 15912-15916	2000/05/26	Refereed	English		Disclose to all
Park S. J., Uesugi, M., Sun, L. J., Crabtree, G. R., Verdine, G. L.		Park S. J., Uesugi, M., Sun, L. J., Crabtree, G. R., Verdine, G. L.	Existence of a Second Calcineurin Binding Site on Select Isoforms of NFAT		Existence of a Second Calcineurin Binding Site on Select Isoforms of NFAT	FASEB Journal, 13, A1495-A1495		FASEB Journal, 13, A1495-A1495	1999		English		Disclose to all
Uesugi, M; Nyanguile, O; Lu, H; Levine, AJ; Verdine, GL		Uesugi, M; Nyanguile, O; Lu, H; Levine, AJ; Verdine, GL	Induced alpha helix in the VP16 activation domain upon binding to a human TAF		Induced alpha helix in the VP16 activation domain upon binding to a human TAF	SCIENCE, 277, 5330, 1310-1313	, 277, 5330, 1310-1313	SCIENCE, 277, 5330, 1310-1313	1997/08/29	Refereed	English		Disclose to all
KUSAKABE, T; UESUGI, M; SUGIURA, Y		KUSAKABE, T; UESUGI, M; SUGIURA, Y	SEQUENCE PREFERENCE FOR STRAND CLEAVAGE OF GAPPED DUPLEXES BY DYNEMICIN-A - POSSIBLE MECHANISM OF SEQUENCE-DEPENDENT DOUBLE-STRANDED BREAKS		SEQUENCE PREFERENCE FOR STRAND CLEAVAGE OF GAPPED DUPLEXES BY DYNEMICIN-A - POSSIBLE MECHANISM OF SEQUENCE-DEPENDENT DOUBLE-STRANDED BREAKS	BIOCHEMISTRY, 34, 31, 9944-9950	, 34, 31, 9944-9950	BIOCHEMISTRY, 34, 31, 9944-9950	1995/08/08	Refereed	English		Disclose to all
UESUGI, M; KUSAKABE, T; SUGIURA, Y		UESUGI, M; KUSAKABE, T; SUGIURA, Y	HYDROPHOBIC DNA-BINDING OF ESPERAMICIN REQUIRES CONFORMATIONAL DISTORTION OF THE HOST DNA		HYDROPHOBIC DNA-BINDING OF ESPERAMICIN REQUIRES CONFORMATIONAL DISTORTION OF THE HOST DNA	BIOCHIMICA ET BIOPHYSICA ACTA-GENE STRUCTURE AND EXPRESSION, 1261, 1, 99-106	, 1261, 1, 99-106	BIOCHIMICA ET BIOPHYSICA ACTA-GENE STRUCTURE AND EXPRESSION, 1261, 1, 99-106	1995/03/14	Refereed	English		Disclose to all
R. Totsuka; Y. Aizawa; M. Uesugi; Y. Okuno; T. Matsumoto; Y. Sugiura		R. Totsuka; Y. Aizawa; M. Uesugi; Y. Okuno; T. Matsumoto; Y. Sugiura	RNA cleavage by C-1027 chromophore, an enediyne antitumor antibiotic: High selectivity to an anticodon arm		RNA cleavage by C-1027 chromophore, an enediyne antitumor antibiotic: High selectivity to an anticodon arm	Biochemical and Biophysical Research Communications, 208, 1, 168-173	, 208, 1, 168-173	Biochemical and Biophysical Research Communications, 208, 1, 168-173	1995/03/08	Refereed	English		Disclose to all
KUSHIDA, T; UESUGI, M; SUGIURA, Y; KIGOSHI, H; TANAKA, H; HIROKAWA, J; OJIKA, M; YAMADA, K		KUSHIDA, T; UESUGI, M; SUGIURA, Y; KIGOSHI, H; TANAKA, H; HIROKAWA, J; OJIKA, M; YAMADA, K	DNA-DAMAGE BY PTAQUILOSIDE, A POTENT BRACKEN CARCINOGEN - DETECTION OF SELECTIVE STRAND BREAKS AND IDENTIFICATION OF DNA CLEAVAGE PRODUCTS		DNA-DAMAGE BY PTAQUILOSIDE, A POTENT BRACKEN CARCINOGEN - DETECTION OF SELECTIVE STRAND BREAKS AND IDENTIFICATION OF DNA CLEAVAGE PRODUCTS	JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 116, 2, 479-486	, 116, 2, 479-486	JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 116, 2, 479-486	1994/01/26	Refereed	English		Disclose to all
KUSAKABE, T; MAEKAWA, K; ICHIKAWA, A; UESUGI, M; SUGIURA, Y		KUSAKABE, T; MAEKAWA, K; ICHIKAWA, A; UESUGI, M; SUGIURA, Y	CONFORMATION-SELECTIVE DNA STRAND BREAKS BY DYNEMICIN - A MOLECULAR WEDGE INTO FLEXIBLE REGIONS OF DNA		CONFORMATION-SELECTIVE DNA STRAND BREAKS BY DYNEMICIN - A MOLECULAR WEDGE INTO FLEXIBLE REGIONS OF DNA	BIOCHEMISTRY, 32, 43, 11669-11675	, 32, 43, 11669-11675	BIOCHEMISTRY, 32, 43, 11669-11675	1993/11/02	Refereed	English		Disclose to all
UESUGI, M; SUGIURA, Y		UESUGI, M; SUGIURA, Y	NEW INSIGHTS INTO SEQUENCE RECOGNITION PROCESS OF ESPERAMICIN-A(1) AND CALICHEAMICIN-GAMMA-1(I) - ORIGIN OF THEIR SELECTIVITIES AND INDUCED FIT MECHANISM		NEW INSIGHTS INTO SEQUENCE RECOGNITION PROCESS OF ESPERAMICIN-A(1) AND CALICHEAMICIN-GAMMA-1(I) - ORIGIN OF THEIR SELECTIVITIES AND INDUCED FIT MECHANISM	BIOCHEMISTRY, 32, 17, 4622-4627	, 32, 17, 4622-4627	BIOCHEMISTRY, 32, 17, 4622-4627	1993/05/04	Refereed	English		Disclose to all
TOKUDA M;FUJIWARA K;GOMIBUCHI T;HIRAMA M;UESUGI M;SUGIURA Y		TOKUDA M;FUJIWARA K;GOMIBUCHI T;HIRAMA M;UESUGI M;SUGIURA Y	Synthesis of a Hybrid Molecule Containing Neocarzinostatin Chromophore Analogue and Minor Groove Binder.		Synthesis of a Hybrid Molecule Containing Neocarzinostatin Chromophore Analogue and Minor Groove Binder.	Tetrahedron Lett, 34, 4, 669-672	, 34, 4, 669-672	Tetrahedron Lett, 34, 4, 669-672	1993/01/22	Refereed	English		Disclose to all
SHIRAKI, T; UESUGI, M; SUGIURA, Y		SHIRAKI, T; UESUGI, M; SUGIURA, Y	C-1' HYDROGEN ABSTRACTION OF DEOXYRIBOSE IN DNA STRAND SCISSION BY DYNEMICIN-A		C-1' HYDROGEN ABSTRACTION OF DEOXYRIBOSE IN DNA STRAND SCISSION BY DYNEMICIN-A	BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 188, 2, 584-589	, 188, 2, 584-589	BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 188, 2, 584-589	1992/10/30	Refereed	English		Disclose to all
UESUGI, M; SUGIURA, Y		UESUGI, M; SUGIURA, Y	PRODUCT ANALYSES IN DNA STRAND SCISSION BY ANTITUMOR ANTIBIOTIC ELSAMICIN-A		PRODUCT ANALYSES IN DNA STRAND SCISSION BY ANTITUMOR ANTIBIOTIC ELSAMICIN-A	BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 186, 1, 580-587	, 186, 1, 580-587	BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 186, 1, 580-587	1992/07/15	Refereed	English		Disclose to all
OWA, T; HAUPT, A; OTSUKA, M; KOBAYASHI, S; TOMIOKA, N; ITAI, A; OHNO, M; SHIRAKI, T; UESUGI, M; SUGIURA, Y; MAEDA, K		OWA, T; HAUPT, A; OTSUKA, M; KOBAYASHI, S; TOMIOKA, N; ITAI, A; OHNO, M; SHIRAKI, T; UESUGI, M; SUGIURA, Y; MAEDA, K	MAN-DESIGNED BLEOMYCINS - SIGNIFICANCE OF THE BINDING-SITES AS ENZYME MODELS AND OF THE STEREOCHEMISTRY OF THE LINKER MOIETY		MAN-DESIGNED BLEOMYCINS - SIGNIFICANCE OF THE BINDING-SITES AS ENZYME MODELS AND OF THE STEREOCHEMISTRY OF THE LINKER MOIETY	TETRAHEDRON, 48, 7, 1193-1208	, 48, 7, 1193-1208	TETRAHEDRON, 48, 7, 1193-1208	1992/02/14	Refereed	English		Disclose to all
HIRAMA, M; GOMIBUCHI, T; FUJIWARA, K; SUGIURA, Y; UESUGI, M		HIRAMA, M; GOMIBUCHI, T; FUJIWARA, K; SUGIURA, Y; UESUGI, M	SYNTHESIS AND DNA-CLEAVING ABILITIES OF FUNCTIONAL NEOCARZINOSTATIN CHROMOPHORE ANALOGS - BASE DISCRIMINATION BY A SIMPLE ALCOHOL		SYNTHESIS AND DNA-CLEAVING ABILITIES OF FUNCTIONAL NEOCARZINOSTATIN CHROMOPHORE ANALOGS - BASE DISCRIMINATION BY A SIMPLE ALCOHOL	JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 113, 26, 9851-9853	, 113, 26, 9851-9853	JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 113, 26, 9851-9853	1991/12/18	Refereed	English		Disclose to all
UESUGI, M; SEKIDA, T; MATSUKI, S; SUGIURA, Y		UESUGI, M; SEKIDA, T; MATSUKI, S; SUGIURA, Y	SELECTIVE DNA CLEAVAGE BY ELSAMICIN-A AND SWITCH FUNCTION OF ITS AMINO SUGAR GROUP		SELECTIVE DNA CLEAVAGE BY ELSAMICIN-A AND SWITCH FUNCTION OF ITS AMINO SUGAR GROUP	BIOCHEMISTRY, 30, 27, 6711-6715	, 30, 27, 6711-6715	BIOCHEMISTRY, 30, 27, 6711-6715	1991/07/09		English		Disclose to all
SUGIURA, Y; ARAKAWA, T; UESUGI, M; SHIRAKI, T; OHKUMA, H; KONISHI, M		SUGIURA, Y; ARAKAWA, T; UESUGI, M; SHIRAKI, T; OHKUMA, H; KONISHI, M	REDUCTIVE AND NUCLEOPHILIC ACTIVATION PRODUCTS OF DYNEMICIN-A WITH METHYL THIOGLYCOLATE - A RATIONAL MECHANISM FOR DNA CLEAVAGE OF THE THIOL-ACTIVATED DYNEMICIN-A		REDUCTIVE AND NUCLEOPHILIC ACTIVATION PRODUCTS OF DYNEMICIN-A WITH METHYL THIOGLYCOLATE - A RATIONAL MECHANISM FOR DNA CLEAVAGE OF THE THIOL-ACTIVATED DYNEMICIN-A	BIOCHEMISTRY, 30, 12, 2989-2992	, 30, 12, 2989-2992	BIOCHEMISTRY, 30, 12, 2989-2992	1991/03/26	Refereed	English		Disclose to all
Uesugi, M.		Uesugi, M.	Small Molecule Tools for Cell Biology and Cell Therapy		Small Molecule Tools for Cell Biology and Cell Therapy	Chembiomolecular Science at the Frontier of Chemistry and Biology , 51-58		Chembiomolecular Science at the Frontier of Chemistry and Biology , 51-58			Other		Disclose to all
<< < > >> Title language:

Books etc

Author	Author(Japanese)	Title	Title(Japanese)	Publisher	Publisher(Japanese)	Publication date	Type	Disclose
日本学術振興会ケミカルバイオロジー第189委員会	日本学術振興会ケミカルバイオロジー第189委員会	ケミカルバイオロジー化合物集　研究展開のヒント	ケミカルバイオロジー化合物集　研究展開のヒント	オーム社	オーム社	2018/10	Other	Disclose to all
上杉　志成	上杉　志成	京都大学アイデアが湧いてくる講義サイエンスの発想法	京都大学アイデアが湧いてくる講義サイエンスの発想法	祥伝社黄金文庫	祥伝社黄金文庫	2017/09	Single Work	Disclose to all
上杉志成	上杉志成	京都大学人気講義　サイエンスの発想法	京都大学人気講義　サイエンスの発想法	祥伝社	祥伝社	2014/04/30	Single Work	Disclose to all
		ケミカルバイオロジー	ケミカルバイオロジー	共立出版	共立出版	2008/05	Joint Editor	Disclose to all
長野哲雄, 長田裕之, 菊地和也, 上杉志成	長野哲雄, 長田裕之, 菊地和也, 上杉志成	ケミカルバイオロジー PNE 蛋白質核酸酵素 2007年10月号増刊	ケミカルバイオロジー PNE 蛋白質核酸酵素 2007年10月号増刊	共立出版	共立出版	2007	Joint Work	Disclose to all
長野哲雄, 長田裕之, 菊地和也, 上杉志成	長野哲雄, 長田裕之, 菊地和也, 上杉志成	ゲノムサイエンスの新たなる挑戦 PNE 蛋白質核酸酵素 2001年12月号増刊	ゲノムサイエンスの新たなる挑戦 PNE 蛋白質核酸酵素 2001年12月号増刊	共立出版	共立出版	2001	Joint Work	Disclose to all
Title language:

Patents

Inventor(s)	Inventor(s) (Japanese)	Title	Title(Japanese)	Stage	Patent number	Date	Disclose
ジョエルハフ, 上杉志成, ジョンキンケイド	ジョエルハフ, 上杉志成, ジョンキンケイド	疾患の治療のための二置換ピラゾール化合物	疾患の治療のための二置換ピラゾール化合物	特許公開	特表2019-515956	2019/06/13	Disclose to all
渡邉瑞貴, 浅野理沙, 長澤和夫, 上杉志成	渡邉瑞貴, 浅野理沙, 長澤和夫, 上杉志成	ビタミンD3誘導体及びその薬学的用途	ビタミンD3誘導体及びその薬学的用途	特許公開	特表2018-502100	2018/01/25	Disclose to all
Title language:

Awards

Title(Japanese)	Title(English)	Organization name(Japanese)	Organization name(English)	Date
若手研究奨励賞	Lymphoma Research Foundation	アメリカリンパ腫研究財団	Young Investigator Award	2001/07/
若手研究奨励賞	Research Scholar Award	アメリカ癌財団	American Cancer Society	2003/07/
ゴールドメダル賞	Gold Medal Award	東京テクノフォーラム21	Tokyo Techno-Forum	2006/04/
学術振興賞	Award for Divisional Scientific Promotions	日本薬学会	The Pharmaceutical Society of Japan	2011/03/
ドイツイノベーションアワードゴットフリード・ワグネル賞 2010 (1等)	German Innovation Award Gottfried Wagener Prize 2010 (1st Prize)	ドイツ科学・イノベーションフォーラム東京、在日ドイツ商工会議所	German Research and Innovation Forum Tokyo & German Chamber of Commerce and Industry in Japan	2011/05/
第49回市村学術賞貢献賞	The 49th Ichimura Prize in Science for Distinguished Achievement	公益財団法人新技術開発財団	The New Technology Development Foundation	2017/04/26

External funds: competitive funds and Grants-in-Aid for Scientific Research (Kakenhi)

Type	Position	Title(Japanese)	Period
基盤研究(B)	Representative	小分子有機化合物を起爆剤とした細胞シグナル解析	2009/04/01-2011/03/31
挑戦的萌芽研究	Representative	転写因子Hes1の振動を制御する小分子化合物（平成26年度分）	2014/04/01-2015/03/31
新学術領域研究（研究領域提案型）	Representative	脂質関連内因性分子の新機能発掘と調節（平成26年度分）	2014/04/01-2015/03/31
基盤研究(S)	Representative	合成小分子化合物による細胞の操作と分析（平成26年度分）	2014/05/30-2015/03/31
基盤研究(S)	Representative	合成小分子化合物による細胞の操作と分析（平成27年度分）	2015/04/01-2016/03/31
挑戦的萌芽研究	Representative	転写因子Hes1の振動を制御する小分子化合物（平成27年度分）	2015/04/01-2016/03/31
新学術領域研究（研究領域提案型）	Representative	脂質関連内因性分子の新機能発掘と調節（平成27年度分）	2015/04/01-2016/03/31
基盤研究(S)	Representative	合成小分子化合物による細胞の操作と分析（平成28年度分）	2016/04/01-2017/03/31
特別研究員奨励費	Representative	ＲＮＡのＧグアドルプレックスを認識する化合物の開発と利用（平成28年度分）	2016/04/01-2017/03/31
挑戦的研究（萌芽）	Representative	人工翻訳後修飾（平成29年度分）	2017/04/01-2018/03/31
基盤研究(S)	Representative	合成小分子化合物による細胞の操作と分析（平成29年度分）	2017/04/01-2018/03/31
新学術領域研究（研究領域提案型）	Representative	人工栄養素結合体の化学シグナル（平成29年度分）	2017/04/01-2018/03/31
特別研究員奨励費	Representative	ＲＮＡのＧグアドルプレックスを認識する化合物の開発と利用（平成29年度分）	2017/04/01-2018/03/31
挑戦的研究（萌芽）	Representative	人工翻訳後修飾（平成30年度分）	2018/04/01-2019/03/31
基盤研究(S)	Representative	合成小分子化合物による細胞の操作と分析（平成30年度分）	2018/04/01-2019/03/31
新学術領域研究（研究領域提案型）	Representative	人工栄養素結合体の化学シグナル（平成30年度分）	2018/04/01-2019/03/31
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External funds: other than those above

System	Main person	Title(Japanese)	Title(English)	Period
独立行政法人科学技術振興機構戦略的創造研究推進事業　さきがけ	上杉　志成	生命現象分析のための小分子転写因子創成		2005/10/-2009/03/
独立行政法人科学技術振興機構研究成果最適展開支援事業（A-STEP）フィージビリティスタディ	上杉　志成	細胞接着促進化合物の実用化		2009/11/01-2010/10/31
独立行政法人日本学術振興会最先端・次世代研究開発支援プログラム	上杉志成	合成小分子化合物による細胞の操作と分析(H23-26)	Control and Analysis of Cells by Synthetic Small Molecules	2011/02/-2014/03/31
独立行政法人日本学術振興会アジア研究教育拠点事業	上杉　志成	アジア発ケミカルバイオロジー(H23-27)	Asian Chemical Biology Initiative	2011/04/01-2016/03/31
独立行政法人科学技術振興機構　戦略的創造研究推進事業CREST	上杉　志成	ケミカルバイオロジーによる脂質内因性分子の新機能研究(H26年度分)	Chemical biological exploration of new functions of endogenous lipid-related molecules	2014/10/01-2015/03/31
国立研究開発法人日本医療研究開発機構(AMED) 革新的先端研究開発支援事業ユニットタイプ「疾患における代謝産物の解析および代謝制御に基づく革新的医療基盤技術の創出」	上杉　志成	ケミカルバイオロジーによる脂質内因性分子の新機能研究(H27-31年度分)	Chemical biological exploration of new functions of endogenous lipid-related molecules	2015/04/01-2020/03/31
文部科学省	上杉　志成	転写機能をターゲットとした創薬「転写を標的とした革新的抗がん化合物シーズ」(H26年度分)		2014/12/21-2015/03/31
国立研究開発法人日本医療研究開発機構(AMED) 次世代がん研究シーズ戦略的育成プログラム　革新的がん医療シーズ育成領域	上杉志成	転写機能をターゲットとした創薬「転写を標的とした革新的抗がん化合物シーズ」 (H27年度分)		2015/04/01-2016/03/31
独立行政法人　科学技術振興機構シーズ発掘試験研究	上杉　志成	アドヘサミンの応用開拓研究		2008/08/12-2009/03/31
アジア研究教育拠点事業	上杉　志成	アジア発ケミカルバイオロジー（平成27年度分）		2015/04/01-2016/03/31
研究拠点形成事業　B.アジア・アフリカ学術基盤形成型	上杉　志成	ケミカルバイオロジー戦略的アジア拠点（平成28年度分）		2016/04/01-2017/03/31
研究拠点形成事業　B.アジア・アフリカ学術基盤形成型	上杉志成	ケミカルバイオロジー戦略的アジア拠点（平成29年度分）		2017/04/01-2018/03/31
研究拠点形成事業　B.アジア・アフリカ学術基盤形成型	上杉志成	ケミカルバイオロジー戦略的アジア拠点（平成30年度分）		2018/04/01-2019/03/31
<< < > >>

Teaching subject(s)

Name(Japanese)	Name(English)	Term	Department	Period
生命の有機化学	The Organic Chemistry of Life	前期	全学共通科目	2011/04-2012/03
生命の有機化学	The Organic Chemistry of Life	前期	全学共通科目	2012/04-2013/03
細胞と物質をつなぐ科学	Integrated Cell-Material Sciences	後期	全学共通科目	2012/04-2013/03
生命の有機化学	The Organic Chemistry of Life	前期	全学共通科目	2013/04-2014/03
生命の有機化学	The Organic Chemistry of Life	前期	全学共通科目	2014/04-2015/03
先端生命科学	Frontier in Life Sciences	通年集中	生命科学研究科	2015/04-2016/03
生命の有機化学	The Organic Chemistry of Life	前期	全学共通科目	2015/04-2016/03
生命の有機化学	Organic Chemistry of Life	前期	全学共通科目	2016/04-2017/03
生命の有機化学	Organic Chemistry of Life	前期	全学共通科目	2017/04-2018/03
生命の有機化学	Organic Chemistry of Life	前期	全学共通科目	2018/04-2019/03
生命の有機化学	Organic Chemistry of Life	前期	全学共通科目	2019/04-2020/03
<< < > >>

Faculty management (title, position)

Title	Period
副拠点長	1970/01/01-
ケミカルスクリーニングセンター長	2011/11/25-2015/11/24
化学研究所運営委員会委員	2017/04/01-2018/03/31
化学研究所広報委員会委員	2017/04/01-2018/03/31
化学研究所将来問題・研究活性化委員会委員	2017/04/01-2018/03/31
	2018/04/01-2019/03/31
	2018/04/01-2019/03/31
	2018/04/01-2020/03/31
化学研究所将来問題・研究活性化委員会委員	2018/04/01-2019/03/31
化学研究所広報委員会委員長	2018/04/01-2019/03/31
化学研究所ゲノムネット推進室運営委員会委員	2018/04/01-2020/03/31
化学研究所将来問題・研究活性化委員会委員	2019/04/01-2020/03/31
化学研究所広報委員会委員長	2019/04/01-2020/03/31
<< < > >>

Other activities (private companies, NPOs, etc.)

Company name	Activity	Period
大鵬薬品工業株式会社	技術アドバイザー	2001-
公益財団法人アステラス病態代謝研究会	学術委員、選考委員	2012/06/24-2020/06/30
内藤記念科学振興財団	選考委員会委員	2013/04/01-
FGH Biotech, Inc. (USA)	Co-Founder	2014/01/-
日本におけるケミカルバイオロジーの新展開第189委員会	委員	2015/04/01-2020/03/31
公益財団法人上原記念生命科学財団	選考委員会委員	2016/04/09-2020/03/31
国立研究開発法人日本医療研究開発機構	AMED課題評価委員　画期的医薬品等の創出をめざす脂質の生理活性と機能の解明	2017/04/01-2019/03/31
文部科学省	科学技術・学術審議会専門委員	2017/04/24-2021/02/14
国立研究開発法人科学技術振興機構	領域アドバイザー　疾患における代謝産物の解析および代謝制御に基づく革新的医療基盤技術の創出	2017/06/25-2019/03/31
Fudan University, School of Pharmacy	Distinguished Professor of Shanghai Thousand Talent Program	2017/07/01-2020/06/30
国立研究開発法人科学技術振興機構	パネルメンバー	2019/04/01-2020/03/31
国立研究開発法人科学技術振興機構	領域アドバイザー	2019/06/01-2021/03/31
<< < > >>

Other activities (other)

Activity	Misc	Period
edX講義「The Chemistry of Life」の提供	ハーバード大学とMITが運営するインターネット教育機関edXに、日本初の講義「The Chemistry of Life（生命の化学）」を英語で世界配信。	2014/04/-

上杉 志成

上杉志成