上杉 志成

Last Update: 2020/07/16 10:39:50

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Name(Kanji/Kana/Abecedarium Latinum)
上杉 志成/ウエスギ モトナリ/Uesugi, Motonari
Primary Affiliation(Org1/Job title)
Institute for Chemical Research (ICR)/Professor
Concurrent Affiliation
Org1 Job title
物質-細胞統合システム拠点 連携PI
Contact Address
Type Address(Japanese) Address(English)
Office 〒611-0011 京都府宇治市五ヶ庄 Gokasho, Uji, Kyoto 6110011, Japan
Phone
Type Number
Office 0774-38-3225
Academic Degree
Field(Japanese) Field(English) University(Japanese) University(English) Method
修士(薬学) M.S. 京都大学 Kyoto University
博士(薬学) Ph.D 京都大学 Kyoto University
Language of Instruction
Language(japanese) Language(english) Code
日本語 Japanese jpn
英語 English eng
Korean (intermediate)
Personal Website(s) (URL(s))
URL
https://www.scl.kyoto-u.ac.jp/~uesugi/ja/index.php
ORCID ID
https://orcid.org/0000-0002-8515-445X
researchmap URL
https://researchmap.jp/read0122106
Research Topics
(Japanese)
ケミカルバイオロジー
(English)
Chemical Biology
Overview of the research
(Japanese)
ケミカルバイオロジーとは、化学を起点とした生物学です。生命の営みはせんじつめれば化学反応でできています。逆に化学を使って生命現象を理解したり、操ることができるはず。私たちの研究室では、生き物やヒト細胞にユニークな効果を及ぼす独自な有機化合物を見つける、もしくはデザインし、それらを道具として生命現象を探究・操作してきました。生物の仕組みは複雑ですが、有機化合物を起爆剤として用いることで、新たな切り口で生物を研究したり操作することができます。私たちの大きな研究目標は、生理活性合成化合物の新しい世界を切り開くことです。生理活性化合物の新しい利用法、新しいカタチをした生理活性化合物、新しいサイズの生理活性化合物など、アイデアを与えることができればと思うのです。こういったアイデアは、未来の創薬の考え方や化合物の細胞治療への利用などに結びつくはずです。
(English)
Chemical biology is an interdisciplinary field of study that is often defined as "chemistry-initiated biology." As biological processes all stem from chemical events, it should be possible to understand or manipulate biological events by using chemistry. Our laboratory has been discovering or designing unique organic molecules that modulate fundamental processes in human cells. Such synthetic organic molecules often serve as tools for basic cell biology. Discovery or design of small molecules with unique biological activity permits small-molecule initiated exploration of complex cellular events. Our mission is to create new world of bioactive synthetic molecules: their new way to use, their new shapes, and their new sizes. We hope to open new avenues for small-molecule applications in a range of fields, including future concepts in drug discovery and use of small molecules for cell therapy.
Fields of research (key words)
Key words(Japanese) Key words(English)
ケミカルバイオロジー Chemical Biology
生理活性小分子 Bioactive Small Molecules
化学プローブ Chemical Probes
細胞治療 Cell Therapy
自己集合 Self-Assembly
化合物ライブラリー Compound Library
Published Papers
Author Author(Japanese) Author(English) Title Title(Japanese) Title(English) Bibliography Bibliography(Japanese) Bibliography(English) Publication date Refereed paper Language Publishing type Disclose
Louvy Lynn Punzalan, Lulu Jiang, Di Mao, Amarjyoti Das Mahapatra, Shinichi Sato, Yasushi Takemoto, Mari Tsujimura, Kosuke Kusamori, Makiya Nishikawa, Lu Zhou, Motonari Uesugi Louvy Lynn Punzalan, Lulu Jiang, Di Mao, Amarjyoti Das Mahapatra, Shinichi Sato, Yasushi Takemoto, Mari Tsujimura, Kosuke Kusamori, Makiya Nishikawa, Lu Zhou, Motonari Uesugi Louvy Lynn Punzalan, Lulu Jiang, Di Mao, Amarjyoti Das Mahapatra, Shinichi Sato, Yasushi Takemoto, Mari Tsujimura, Kosuke Kusamori, Makiya Nishikawa, Lu Zhou, Motonari Uesugi Chemoproteomic Profiling of a Pharmacophore-Focused Chemical Library. Chemoproteomic Profiling of a Pharmacophore-Focused Chemical Library. Chemoproteomic Profiling of a Pharmacophore-Focused Chemical Library. Cell chemical biology Cell chemical biology Cell chemical biology 2020/04/28 Refereed English Research paper(scientific journal) Disclose to all
Yasushi Takemoto, Di Mao, Louvy Lynn Punzalan, Sebastian Götze, Shin-Ichi Sato, Motonari Uesugi Yasushi Takemoto, Di Mao, Louvy Lynn Punzalan, Sebastian Götze, Shin-Ichi Sato, Motonari Uesugi Yasushi Takemoto, Di Mao, Louvy Lynn Punzalan, Sebastian Götze, Shin-Ichi Sato, Motonari Uesugi Discovery of a Small-Molecule-Dependent Photolytic Peptide. Discovery of a Small-Molecule-Dependent Photolytic Peptide. Discovery of a Small-Molecule-Dependent Photolytic Peptide. Journal of the American Chemical Society, 142, 3, 1142-1146 Journal of the American Chemical Society, 142, 3, 1142-1146 Journal of the American Chemical Society, 142, 3, 1142-1146 2020/01/22 Refereed English Disclose to all
Akiko Nagata, Yusuke Akagi, Lisa Asano, Kenjiro Kotake, Fumihiro Kawagoe, Aileen Mendoza, Shadi Sedghi Masoud, Kosuke Usuda, Koji Yasui, Yasushi Takemoto, Atsushi Kittaka, Kazuo Nagasawa, Motonari Uesugi Nagata A, Akagi Y, Asano L, Kotake K, Kawagoe F, Mendoza A, Masoud SS, Usuda K, Yasui K, Takemoto Y, Kittaka A, Nagasawa K, Uesugi M Akiko Nagata, Yusuke Akagi, Lisa Asano, Kenjiro Kotake, Fumihiro Kawagoe, Aileen Mendoza, Shadi Sedghi Masoud, Kosuke Usuda, Koji Yasui, Yasushi Takemoto, Atsushi Kittaka, Kazuo Nagasawa, Motonari Uesugi Synthetic Chemical Probes That Dissect Vitamin D Activities. Synthetic Chemical Probes That Dissect Vitamin D Activities. Synthetic Chemical Probes That Dissect Vitamin D Activities. ACS chemical biology, 14, 12, 2851-2858 ACS chemical biology, 14, 12, 2851-2858 ACS chemical biology, 14, 12, 2851-2858 2019/12/20 Refereed English Disclose to all
Furuta T, Mizukami Y, Asano L, Kotake K, Ziegler S, Yoshida H, Watanabe M, Sato SI, Waldmann H, Nishikawa M, Uesugi M Furuta T, Mizukami Y, Asano L, Kotake K, Ziegler S, Yoshida H, Watanabe M, Sato SI, Waldmann H, Nishikawa M, Uesugi M Furuta T, Mizukami Y, Asano L, Kotake K, Ziegler S, Yoshida H, Watanabe M, Sato SI, Waldmann H, Nishikawa M, Uesugi M Nutrient-Based Chemical Library as a Source of Energy Metabolism Modulators. Nutrient-Based Chemical Library as a Source of Energy Metabolism Modulators. Nutrient-Based Chemical Library as a Source of Energy Metabolism Modulators. ACS chemical biology, 14, 9, 1860-1865 ACS chemical biology, 14, 9, 1860-1865 ACS chemical biology, 14, 9, 1860-1865 2019/09 Refereed Disclose to all
Ippei Takashima, Kosuke Kusamori, Hayase Hakariya, Megumi Takashima, Thi Hue Vu, Yuya Mizukami, Naotaka Noda, Yukiya Takayama, Yousuke Katsuda, Shin-ichi Sato, Yoshinobu Takakura, Makiya Nishikawa, Motonari Uesugi Ippei Takashima, Kosuke Kusamori, Hayase Hakariya, Megumi Takashima, Thi Hue Vu, Yuya Mizukami, Naotaka Noda, Yukiya Takayama, Yousuke Katsuda, Shin-ichi Sato, Yoshinobu Takakura, Makiya Nishikawa, Motonari Uesugi Ippei Takashima, Kosuke Kusamori, Hayase Hakariya, Megumi Takashima, Thi Hue Vu, Yuya Mizukami, Naotaka Noda, Yukiya Takayama, Yousuke Katsuda, Shin-ichi Sato, Yoshinobu Takakura, Makiya Nishikawa, Motonari Uesugi Multifunctionalization of Cells with a Self-Assembling Molecule to Enhance Cell Engraftment Multifunctionalization of Cells with a Self-Assembling Molecule to Enhance Cell Engraftment Multifunctionalization of Cells with a Self-Assembling Molecule to Enhance Cell Engraftment ACS Chemical Biology, 14, 4, 775-783 ACS Chemical Biology, 14, 4, 775-783 ACS Chemical Biology, 14, 4, 775-783 2019/04/19 Refereed Research paper(scientific journal) Disclose to all
Mao D, Chung XKW, Andoh-Noda T, Qin Y, Sato SI, Takemoto Y, Akamatsu W, Okano H, Uesugi M Mao D, Chung XKW, Andoh-Noda T, Qin Y, Sato SI, Takemoto Y, Akamatsu W, Okano H, Uesugi M Mao D, Chung XKW, Andoh-Noda T, Qin Y, Sato SI, Takemoto Y, Akamatsu W, Okano H, Uesugi M Chemical decontamination of iPS cell-derived neural cell mixtures. Chemical decontamination of iPS cell-derived neural cell mixtures. Chemical decontamination of iPS cell-derived neural cell mixtures. Chemical communications (Cambridge, England), 54, 11, 1355-1358 Chemical communications (Cambridge, England), 54, 11, 1355-1358 Chemical communications (Cambridge, England), 54, 11, 1355-1358 2018/02 Refereed Disclose to all
Kenji Yatsuzuka, Shin-ichi Sato, Kathleen Beverly Pe, Yousuke Katsuda, Ippei Takashima, Mizuki Watanabe, Motonari Uesugi Kenji Yatsuzuka, Shin-ichi Sato, Kathleen Beverly Pe, Yousuke Katsuda, Ippei Takashima, Mizuki Watanabe, Motonari Uesugi Kenji Yatsuzuka, Shin-ichi Sato, Kathleen Beverly Pe, Yousuke Katsuda, Ippei Takashima, Mizuki Watanabe, Motonari Uesugi Live-cell imaging of multiple endogenous mRNAs permits the direct observation of RNA granule dynamics Live-cell imaging of multiple endogenous mRNAs permits the direct observation of RNA granule dynamics Live-cell imaging of multiple endogenous mRNAs permits the direct observation of RNA granule dynamics Chemical Communications, 54, 52, 7151-7154 Chemical Communications, 54, 52, 7151-7154 Chemical Communications, 54, 52, 7151-7154 2018 Refereed Research paper(scientific journal) Disclose to all
Shin-ichi Sato, Kenji Yatsuzuka, Yousuke Katsuda, Motonari Uesugi Shin-ichi Sato, Kenji Yatsuzuka, Yousuke Katsuda, Motonari Uesugi Shin-ichi Sato, Kenji Yatsuzuka, Yousuke Katsuda, Motonari Uesugi Method for Imaging Live-Cell RNA Using an RNA Aptamer and a Fluorescent Probe Method for Imaging Live-Cell RNA Using an RNA Aptamer and a Fluorescent Probe Method for Imaging Live-Cell RNA Using an RNA Aptamer and a Fluorescent Probe Methods in Molecular Biology, 1649, 305-318 Methods in Molecular Biology, 1649, 305-318 Methods in Molecular Biology, 1649, 305-318 2018 Refereed Disclose to all
Amelie Perron, Yoshihiro Nishikawa, Jun Iwata, Hiromi Shimojo, Junichiro Takaya, Kumiko Kobayashi, Itaru Imayoshi, Naasson M. Mbenza, Mihoko Takenoya, Ryoichiro Kageyama, Yuzo Kodama, Motonari Uesugi Amelie Perron, Yoshihiro Nishikawa, Jun Iwata, Hiromi Shimojo, Junichiro Takaya, Kumiko Kobayashi, Itaru Imayoshi, Naasson M. Mbenza, Mihoko Takenoya, Ryoichiro Kageyama, Yuzo Kodama, Motonari Uesugi Amelie Perron, Yoshihiro Nishikawa, Jun Iwata, Hiromi Shimojo, Junichiro Takaya, Kumiko Kobayashi, Itaru Imayoshi, Naasson M. Mbenza, Mihoko Takenoya, Ryoichiro Kageyama, Yuzo Kodama, Motonari Uesugi Small-molecule screening yields a compound that inhibits the cancer-associated transcription factor Hes1 via the PHB2 chaperone Small-molecule screening yields a compound that inhibits the cancer-associated transcription factor Hes1 via the PHB2 chaperone Small-molecule screening yields a compound that inhibits the cancer-associated transcription factor Hes1 via the PHB2 chaperone Journal of Biological Chemistry, 293, 21, 8285-8294 Journal of Biological Chemistry, 293, 21, 8285-8294 Journal of Biological Chemistry, 293, 21, 8285-8294 2018 Refereed Disclose to all
Asano L, Watanabe M, Ryoden Y, Usuda K, Yamaguchi T, Khambu B, Takashima M, Sato SI, Sakai J, Nagasawa K, Uesugi M Asano L, Watanabe M, Ryoden Y, Usuda K, Yamaguchi T, Khambu B, Takashima M, Sato SI, Sakai J, Nagasawa K, Uesugi M Asano L, Watanabe M, Ryoden Y, Usuda K, Yamaguchi T, Khambu B, Takashima M, Sato SI, Sakai J, Nagasawa K, Uesugi M Vitamin D Metabolite, 25-Hydroxyvitamin D, Regulates Lipid Metabolism by Inducing Degradation of SREBP/SCAP. Vitamin D Metabolite, 25-Hydroxyvitamin D, Regulates Lipid Metabolism by Inducing Degradation of SREBP/SCAP. Vitamin D Metabolite, 25-Hydroxyvitamin D, Regulates Lipid Metabolism by Inducing Degradation of SREBP/SCAP. Cell chemical biology, 24, 2, 207-217 Cell Chemical Biology, 24, 2, 207-217 Cell chemical biology, 24, 2, 207-217 2017/02 Refereed Disclose to all
Di Mao, Shin Ando, Shin-ichi Sato, Ying Qin, Nao Hirata, Yousuke Katsuda, Eihachiro Kawase, Ting-Fang Kuo, Itsunari Minami, Yuji Shiba, Kazumitsu Ueda, Norio Nakatsuji, Motonari Uesugi Di Mao, Shin Ando, Shin-ichi Sato, Ying Qin, Nao Hirata, Yousuke Katsuda, Eihachiro Kawase, Ting-Fang Kuo, Itsunari Minami, Yuji Shiba, Kazumitsu Ueda, Norio Nakatsuji, Motonari Uesugi Di Mao, Shin Ando, Shin-ichi Sato, Ying Qin, Nao Hirata, Yousuke Katsuda, Eihachiro Kawase, Ting-Fang Kuo, Itsunari Minami, Yuji Shiba, Kazumitsu Ueda, Norio Nakatsuji, Motonari Uesugi A Synthetic Hybrid Molecule for the Selective Removal of Human Pluripotent Stem Cells from Cell Mixtures A Synthetic Hybrid Molecule for the Selective Removal of Human Pluripotent Stem Cells from Cell Mixtures A Synthetic Hybrid Molecule for the Selective Removal of Human Pluripotent Stem Cells from Cell Mixtures ANGEWANDTE CHEMIE-INTERNATIONAL EDITION, 56, 7, 1765-1770 ANGEWANDTE CHEMIE-INTERNATIONAL EDITION, 56, 7, 1765-1770 ANGEWANDTE CHEMIE-INTERNATIONAL EDITION, 56, 7, 1765-1770 2017/02 Refereed English Research paper(scientific journal) Disclose to all
Lisa Asano, Mizuki Watanabe, Yuta Ryoden, Kousuke Usuda, Takuya Yamaguchi, Bilon Khambu, Megumi Takashima, Shin-ichi Sato, Juro Sakai, Kazuo Nagasawa, Motonari Uesugi Lisa Asano, Mizuki Watanabe, Yuta Ryoden, Kousuke Usuda, Takuya Yamaguchi, Bilon Khambu, Megumi Takashima, Shin-ichi Sato, Juro Sakai, Kazuo Nagasawa, Motonari Uesugi Lisa Asano, Mizuki Watanabe, Yuta Ryoden, Kousuke Usuda, Takuya Yamaguchi, Bilon Khambu, Megumi Takashima, Shin-ichi Sato, Juro Sakai, Kazuo Nagasawa, Motonari Uesugi Vitamin D Metabolite, 25-Hydroxyvitamin D, Regulates Lipid Metabolism by Inducing Degradation of SREBP/SCAP Vitamin D Metabolite, 25-Hydroxyvitamin D, Regulates Lipid Metabolism by Inducing Degradation of SREBP/SCAP Vitamin D Metabolite, 25-Hydroxyvitamin D, Regulates Lipid Metabolism by Inducing Degradation of SREBP/SCAP CELL CHEMICAL BIOLOGY, 24, 2, 207-217 CELL CHEMICAL BIOLOGY, 24, 2, 207-217 CELL CHEMICAL BIOLOGY, 24, 2, 207-217 2017/02 Refereed English Research paper(scientific journal) Disclose to all
Yusuke Akagi, Kosuke Usuda, Tomoe Tanami, Koji Yasui, Lisa Asano, Motonari Uesugi, Kazuo Nagasawa Yusuke Akagi, Kosuke Usuda, Tomoe Tanami, Koji Yasui, Lisa Asano, Motonari Uesugi, Kazuo Nagasawa Yusuke Akagi, Kosuke Usuda, Tomoe Tanami, Koji Yasui, Lisa Asano, Motonari Uesugi, Kazuo Nagasawa Synthesis of 1 alpha- and 1 beta-amino-25-hydroxyvitamin D-3 Synthesis of 1 alpha- and 1 beta-amino-25-hydroxyvitamin D-3 Synthesis of 1 alpha- and 1 beta-amino-25-hydroxyvitamin D-3 ASIAN JOURNAL OF ORGANIC CHEMISTRY, 5, 10, 1247-1252 ASIAN JOURNAL OF ORGANIC CHEMISTRY, 5, 10, 1247-1252 ASIAN JOURNAL OF ORGANIC CHEMISTRY, 5, 10, 1247-1252 2016/10 Refereed English Research paper(scientific journal) Disclose to all
Yousuke Katsuda, Shin-ichi Sato, Lisa Asano, Yoshitaka Morimura, Tomoyuki Furuta, Hiroshi Sugiyama, Masaki Hagihara, Motonari Uesugi Yousuke Katsuda, Shin-ichi Sato, Lisa Asano, Yoshitaka Morimura, Tomoyuki Furuta, Hiroshi Sugiyama, Masaki Hagihara, Motonari Uesugi Yousuke Katsuda, Shin-ichi Sato, Lisa Asano, Yoshitaka Morimura, Tomoyuki Furuta, Hiroshi Sugiyama, Masaki Hagihara, Motonari Uesugi A Small Molecule That Represses Translation of G-Quadruplex-Containing mRNA A Small Molecule That Represses Translation of G-Quadruplex-Containing mRNA A Small Molecule That Represses Translation of G-Quadruplex-Containing mRNA JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 138, 29, 9037-9040 JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 138, 29, 9037-9040 JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 138, 29, 9037-9040 2016/07 Refereed English Research paper(scientific journal) Disclose to all
Junichiro Takaya, Kazuhiro Mio, Takuya Shiraishi, Tatsuki Kurokawa, Shinya Otsuka, Yasuo Mori, Motonari Uesugi Junichiro Takaya, Kazuhiro Mio, Takuya Shiraishi, Tatsuki Kurokawa, Shinya Otsuka, Yasuo Mori, Motonari Uesugi Junichiro Takaya, Kazuhiro Mio, Takuya Shiraishi, Tatsuki Kurokawa, Shinya Otsuka, Yasuo Mori, Motonari Uesugi A Potent and Site-Selective Agonist of TRPA1 A Potent and Site-Selective Agonist of TRPA1 A Potent and Site-Selective Agonist of TRPA1 JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 137, 50, 15859-15864 JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 137, 50, 15859-15864 JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 137, 50, 15859-15864 2015/12 Refereed English Research paper(scientific journal) Disclose to all
S. Sato, M. Watanabe, Y. Katsuda, A. Murata, D.O. Wang, M. Uesugi S. Sato, M. Watanabe, Y. Katsuda, A. Murata, D.O. Wang, M. Uesugi S. Sato, M. Watanabe, Y. Katsuda, A. Murata, D.O. Wang, M. Uesugi Live-cell Imaging of Endogenous mRNAs with a Small Molecule Live-cell Imaging of Endogenous mRNAs with a Small Molecule Live-cell Imaging of Endogenous mRNAs with a Small Molecule Angewandte Chemie International Edition in English, 127, 1875-1878 Angewandte Chemie International Edition in English, 127, 1875-1878 Angewandte Chemie International Edition in English, 127, 1875-1878 2015/02 Refereed English Disclose to all
Shin-ichi Sato, Mizuki Watanabe, Yousuke Katsuda, Asako Murata, Dan Ohtan Wang, Motonari Uesugi Shin-ichi Sato, Mizuki Watanabe, Yousuke Katsuda, Asako Murata, Dan Ohtan Wang, Motonari Uesugi Shin-ichi Sato, Mizuki Watanabe, Yousuke Katsuda, Asako Murata, Dan Ohtan Wang, Motonari Uesugi Live-Cell Imaging of Endogenous mRNAs with a Small Molecule Live-Cell Imaging of Endogenous mRNAs with a Small Molecule Live-Cell Imaging of Endogenous mRNAs with a Small Molecule ANGEWANDTE CHEMIE-INTERNATIONAL EDITION, 54, 6, 1855-1858 ANGEWANDTE CHEMIE-INTERNATIONAL EDITION, 54, 6, 1855-1858 ANGEWANDTE CHEMIE-INTERNATIONAL EDITION, 54, 6, 1855-1858 2015/02 Refereed English Research paper(scientific journal) Disclose to all
Heidie L. Frisco-Cabanos, Mizuki Watanabe, Naoki Okumura, Kosuke Kusamori, Naohiro Takemoto, Junichiro Takaya, Shin-ichi Sato, Sayumi Yamazoe, Yoshinobu Takakura, Shigeru Kinoshita, Makiya Nishikawa, Noriko Koizumi, Motonari Uesugi Heidie L. Frisco-Cabanos, Mizuki Watanabe, Naoki Okumura, Kosuke Kusamori, Naohiro Takemoto, Junichiro Takaya, Shin-ichi Sato, Sayumi Yamazoe, Yoshinobu Takakura, Shigeru Kinoshita, Makiya Nishikawa, Noriko Koizumi, Motonari Uesugi Heidie L. Frisco-Cabanos, Mizuki Watanabe, Naoki Okumura, Kosuke Kusamori, Naohiro Takemoto, Junichiro Takaya, Shin-ichi Sato, Sayumi Yamazoe, Yoshinobu Takakura, Shigeru Kinoshita, Makiya Nishikawa, Noriko Koizumi, Motonari Uesugi Synthetic Molecules that Protect Cells from Anoikis and Their Use in Cell Transplantation Synthetic Molecules that Protect Cells from Anoikis and Their Use in Cell Transplantation Synthetic Molecules that Protect Cells from Anoikis and Their Use in Cell Transplantation ANGEWANDTE CHEMIE-INTERNATIONAL EDITION, 53, 42, 11208-11213 ANGEWANDTE CHEMIE-INTERNATIONAL EDITION, 53, 42, 11208-11213 ANGEWANDTE CHEMIE-INTERNATIONAL EDITION, 53, 42, 11208-11213 2014/10 Refereed English Research paper(scientific journal) Disclose to all
Ting-Fang Kuo, Di Mao, Nao Hirata, Bilon Khambu, Yasuhisa Kimura, Eihachiro Kawase, Hiroki Shimogawa, Makoto Ojika, Norio Nakatsuji, Kazumitsu Ueda, Motonari Uesugi Ting-Fang Kuo, Di Mao, Nao Hirata, Bilon Khambu, Yasuhisa Kimura, Eihachiro Kawase, Hiroki Shimogawa, Makoto Ojika, Norio Nakatsuji, Kazumitsu Ueda, Motonari Uesugi Ting-Fang Kuo, Di Mao, Nao Hirata, Bilon Khambu, Yasuhisa Kimura, Eihachiro Kawase, Hiroki Shimogawa, Makoto Ojika, Norio Nakatsuji, Kazumitsu Ueda, Motonari Uesugi Selective Elimination of Human Pluripotent Stem Cells by a Marine Natural Product Derivative Selective Elimination of Human Pluripotent Stem Cells by a Marine Natural Product Derivative Selective Elimination of Human Pluripotent Stem Cells by a Marine Natural Product Derivative JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 136, 28, 9798-9801 JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 136, 28, 9798-9801 JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 136, 28, 9798-9801 2014/07 Refereed English Research paper(scientific journal) Disclose to all
Nao Hirata, Masato Nakagawa, Yuto Fujibayashi, Kaori Yamauchi, Asako Murata, Itsunari Minami, Maiko Tomioka, Takayuki Kondo, Ting-Fang Kuo, Hiroshi Endo, Haruhisa Inoue, Shin-ichi Sato, Shin Ando, Yoshinori Kawazoe, Kazuhiro Aiba, Koh Nagata, Eihachiro Kawase, Young-Tae Chang, Hirofumi Suemori, Koji Eto, Hiromitsu Nakauchi, Shinya Yamanaka, Norio Nakatsuji, Kazumitsu Ueda, Motonari Uesugi Nao Hirata, Masato Nakagawa, Yuto Fujibayashi, Kaori Yamauchi, Asako Murata, Itsunari Minami, Maiko Tomioka, Takayuki Kondo, Ting-Fang Kuo, Hiroshi Endo, Haruhisa Inoue, Shin-ichi Sato, Shin Ando, Yoshinori Kawazoe, Kazuhiro Aiba, Koh Nagata, Eihachiro Kawase, Young-Tae Chang, Hirofumi Suemori, Koji Eto, Hiromitsu Nakauchi, Shinya Yamanaka, Norio Nakatsuji, Kazumitsu Ueda, Motonari Uesugi Nao Hirata, Masato Nakagawa, Yuto Fujibayashi, Kaori Yamauchi, Asako Murata, Itsunari Minami, Maiko Tomioka, Takayuki Kondo, Ting-Fang Kuo, Hiroshi Endo, Haruhisa Inoue, Shin-ichi Sato, Shin Ando, Yoshinori Kawazoe, Kazuhiro Aiba, Koh Nagata, Eihachiro Kawase, Young-Tae Chang, Hirofumi Suemori, Koji Eto, Hiromitsu Nakauchi, Shinya Yamanaka, Norio Nakatsuji, Kazumitsu Ueda, Motonari Uesugi A Chemical Probe that Labels Human Pluripotent Stem Cells A Chemical Probe that Labels Human Pluripotent Stem Cells A Chemical Probe that Labels Human Pluripotent Stem Cells CELL REPORTS, 6, 6, 1165-1174 CELL REPORTS, 6, 6, 1165-1174 CELL REPORTS, 6, 6, 1165-1174 2014/03 Refereed English Research paper(scientific journal) Disclose to all
Daisuke Sakano, Nobuaki Shiraki, Kazuhide Kikawa, Taiji Yamazoe, Masateru Kataoka, Kahoko Umeda, Kimi Araki, Di Mao, Shirou Matsumoto, Naomi Nakagata, Olov Andersson, Didier Stainier, Fumio Endo, Kazuhiko Kume, Motonari Uesugi, Shoen Kume Sakano D, Shiraki N, Kikawa K, Yamazoe T, Kataoka M, Umeda K, Araki K, Mao D, Matsumoto S, Nakagata N, Andersson O, Stainier D, Endo F, Kume K, Uesugi M, Kume S Daisuke Sakano, Nobuaki Shiraki, Kazuhide Kikawa, Taiji Yamazoe, Masateru Kataoka, Kahoko Umeda, Kimi Araki, Di Mao, Shirou Matsumoto, Naomi Nakagata, Olov Andersson, Didier Stainier, Fumio Endo, Kazuhiko Kume, Motonari Uesugi, Shoen Kume VMAT2 identified as a regulator of late-stage beta-cell differentiation VMAT2 identified as a regulator of late-stage β-cell differentiation. VMAT2 identified as a regulator of late-stage beta-cell differentiation NATURE CHEMICAL BIOLOGY, 10, 2, 141-148 Nature chemical biology, 10, 2, 141-148 NATURE CHEMICAL BIOLOGY, 10, 2, 141-148 2014/02 Refereed English Research paper(scientific journal) Disclose to all
Naohiro Takemoto, Tetsuya Suehara, Heidie L. Frisco, Shin-ichi Sato, Takuhito Sezaki, Kosuke Kusamori, Yoshinori Kawazoe, Sun Min Park, Sayumi Yamazoe, Yoshiyuki Mizuhata, Rintaro Inoue, Gavin J. Miller, Steen U. Hansen, Gordon C. Jayson, John M. Gardiner, Toshiji Kanaya, Norihiro Tokitoh, Kazumitsu Ueda, Yoshinobu Takakura, Noriyuki Kioka, Makiya Nishikawa, Motonari Uesugi Naohiro Takemoto, Tetsuya Suehara, Heidie L. Frisco, Shin-ichi Sato, Takuhito Sezaki, Kosuke Kusamori, Yoshinori Kawazoe, Sun Min Park, Sayumi Yamazoe, Yoshiyuki Mizuhata, Rintaro Inoue, Gavin J. Miller, Steen U. Hansen, Gordon C. Jayson, John M. Gardiner, Toshiji Kanaya, Norihiro Tokitoh, Kazumitsu Ueda, Yoshinobu Takakura, Noriyuki Kioka, Makiya Nishikawa, Motonari Uesugi Naohiro Takemoto, Tetsuya Suehara, Heidie L. Frisco, Shin-ichi Sato, Takuhito Sezaki, Kosuke Kusamori, Yoshinori Kawazoe, Sun Min Park, Sayumi Yamazoe, Yoshiyuki Mizuhata, Rintaro Inoue, Gavin J. Miller, Steen U. Hansen, Gordon C. Jayson, John M. Gardiner, Toshiji Kanaya, Norihiro Tokitoh, Kazumitsu Ueda, Yoshinobu Takakura, Noriyuki Kioka, Makiya Nishikawa, Motonari Uesugi Small-Molecule-Induced Clustering of Heparan Sulfate Promotes Cell Adhesion Small-Molecule-Induced Clustering of Heparan Sulfate Promotes Cell Adhesion Small-Molecule-Induced Clustering of Heparan Sulfate Promotes Cell Adhesion JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 135, 30, 11032-11039 JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 135, 30, 11032-11039 JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 135, 30, 11032-11039 2013/07 Refereed English Research paper(scientific journal) Disclose to all
Takayoshi Suzuki, Midori A. Arai, Mitsue Nakashima, Motonari Uesugi Takayoshi Suzuki, Midori A. Arai, Mitsue Nakashima, Motonari Uesugi Takayoshi Suzuki, Midori A. Arai, Mitsue Nakashima, Motonari Uesugi Merging Chemistry and Biology in Emerging Countries Merging Chemistry and Biology in Emerging Countries Merging Chemistry and Biology in Emerging Countries CHEMISTRY & BIOLOGY, 20, 4, 461-465 CHEMISTRY & BIOLOGY, 20, 4, 461-465 CHEMISTRY & BIOLOGY, 20, 4, 461-465 2013/04 Refereed English Research paper(scientific journal) Disclose to all
Dongju Jung, Lutfi Abu-Elheiga, Rie Ayuzawa, Ziwei Gu, Takashi Shirakawa, Yukio Fujiki, Norio Nakatsuji, Salih J. Wakil, Motonari Uesugi Dongju Jung, Lutfi Abu-Elheiga, Rie Ayuzawa, Ziwei Gu, Takashi Shirakawa, Yukio Fujiki, Norio Nakatsuji, Salih J. Wakil, Motonari Uesugi Dongju Jung, Lutfi Abu-Elheiga, Rie Ayuzawa, Ziwei Gu, Takashi Shirakawa, Yukio Fujiki, Norio Nakatsuji, Salih J. Wakil, Motonari Uesugi Mislocalization and inhibition of acetyl-CoA carboxylase 1 by a synthetic small molecule Mislocalization and inhibition of acetyl-CoA carboxylase 1 by a synthetic small molecule Mislocalization and inhibition of acetyl-CoA carboxylase 1 by a synthetic small molecule BIOCHEMICAL JOURNAL, 448, 3, 409-416 BIOCHEMICAL JOURNAL, 448, 3, 409-416 BIOCHEMICAL JOURNAL, 448, 3, 409-416 2012/12 Refereed English Research paper(scientific journal) Disclose to all
Itsunari Minami, Kohei Yamada, Tomomi G. Otsuji, Takuya Yamamoto, Yan Shen, Shinya Otsuka, Shin Kadota, Nobuhiro Morone, Maneesha Barve, Yasuyuki Asai, Tatyana Tenkova-Heuser, John E. Heuser, Motonari Uesugi, Kazuhiro Aiba, Norio Nakatsuji Itsunari Minami, Kohei Yamada, Tomomi G. Otsuji, Takuya Yamamoto, Yan Shen, Shinya Otsuka, Shin Kadota, Nobuhiro Morone, Maneesha Barve, Yasuyuki Asai, Tatyana Tenkova-Heuser, John E. Heuser, Motonari Uesugi, Kazuhiro Aiba, Norio Nakatsuji Itsunari Minami, Kohei Yamada, Tomomi G. Otsuji, Takuya Yamamoto, Yan Shen, Shinya Otsuka, Shin Kadota, Nobuhiro Morone, Maneesha Barve, Yasuyuki Asai, Tatyana Tenkova-Heuser, John E. Heuser, Motonari Uesugi, Kazuhiro Aiba, Norio Nakatsuji A Small Molecule that Promotes Cardiac Differentiation of Human Pluripotent Stem Cells under Defined, Cytokine- and Xeno-free Conditions A Small Molecule that Promotes Cardiac Differentiation of Human Pluripotent Stem Cells under Defined, Cytokine- and Xeno-free Conditions A Small Molecule that Promotes Cardiac Differentiation of Human Pluripotent Stem Cells under Defined, Cytokine- and Xeno-free Conditions CELL REPORTS, 2, 5, 1448-1460 CELL REPORTS, 2, 5, 1448-1460 CELL REPORTS, 2, 5, 1448-1460 2012/11 Refereed English Research paper(scientific journal) Disclose to all
Takashii Morii, Motonari Uesugi Takashii Morii, Motonari Uesugi Takashii Morii, Motonari Uesugi Two Days of Experiments in Vietnam: Asian Chemical Biology Initiative, Hanoi Meeting Two Days of Experiments in Vietnam: Asian Chemical Biology Initiative, Hanoi Meeting Two Days of Experiments in Vietnam: Asian Chemical Biology Initiative, Hanoi Meeting ACS CHEMICAL BIOLOGY, 7, 4, 623-625 ACS CHEMICAL BIOLOGY, 7, 4, 623-625 ACS CHEMICAL BIOLOGY, 7, 4, 623-625 2012/04 Refereed English Disclose to all
Bilon Khambu, Motonari Uesugi, Yoshinori Kawazoe Bilon Khambu, Motonari Uesugi, Yoshinori Kawazoe Bilon Khambu, Motonari Uesugi, Yoshinori Kawazoe Translational repression stabilizes messenger RNA of autophagy-related genes Translational repression stabilizes messenger RNA of autophagy-related genes Translational repression stabilizes messenger RNA of autophagy-related genes GENES TO CELLS, 16, 8, 857-867 GENES TO CELLS, 16, 8, 857-867 GENES TO CELLS, 16, 8, 857-867 2011/08 Refereed English Research paper(scientific journal) Disclose to all
Shinji Kamisuki, Takashi Shirakawa, Akira Kugimiya, Lutfi Abu-Elheiga, Hea-Young Park Choo, Kohei Yamada, Hiroki Shimogawa, Salih J. Wakil, Motonari Uesugi Shinji Kamisuki, Takashi Shirakawa, Akira Kugimiya, Lutfi Abu-Elheiga, Hea-Young Park Choo, Kohei Yamada, Hiroki Shimogawa, Salih J. Wakil, Motonari Uesugi Shinji Kamisuki, Takashi Shirakawa, Akira Kugimiya, Lutfi Abu-Elheiga, Hea-Young Park Choo, Kohei Yamada, Hiroki Shimogawa, Salih J. Wakil, Motonari Uesugi Synthesis and Evaluation of Diarylthiazole Derivatives That Inhibit Activation of Sterol Regulatory Element-Binding Proteins Synthesis and Evaluation of Diarylthiazole Derivatives That Inhibit Activation of Sterol Regulatory Element-Binding Proteins Synthesis and Evaluation of Diarylthiazole Derivatives That Inhibit Activation of Sterol Regulatory Element-Binding Proteins JOURNAL OF MEDICINAL CHEMISTRY, 54, 13, 4923-4927 JOURNAL OF MEDICINAL CHEMISTRY, 54, 13, 4923-4927 JOURNAL OF MEDICINAL CHEMISTRY, 54, 13, 4923-4927 2011/07 Refereed English Research paper(scientific journal) Disclose to all
Eriko Sumiya, Hiroki Shimogawa, Hiroaki Sasaki, Masato Tsutsumi, Ken'ichi Yoshita, Makoto Ojika, Kiyotake Suenaga, Motonari Uesugi Eriko Sumiya, Hiroki Shimogawa, Hiroaki Sasaki, Masato Tsutsumi, Ken'ichi Yoshita, Makoto Ojika, Kiyotake Suenaga, Motonari Uesugi Eriko Sumiya, Hiroki Shimogawa, Hiroaki Sasaki, Masato Tsutsumi, Ken'ichi Yoshita, Makoto Ojika, Kiyotake Suenaga, Motonari Uesugi Cell-Morphology Profiling of a Natural Product Library Identifies Bisebromoamide and Miuraenamide A as Actin Filament Stabilizers Cell-Morphology Profiling of a Natural Product Library Identifies Bisebromoamide and Miuraenamide A as Actin Filament Stabilizers Cell-Morphology Profiling of a Natural Product Library Identifies Bisebromoamide and Miuraenamide A as Actin Filament Stabilizers ACS CHEMICAL BIOLOGY, 6, 5, 425-431 ACS CHEMICAL BIOLOGY, 6, 5, 425-431 ACS CHEMICAL BIOLOGY, 6, 5, 425-431 2011/05 Refereed English Research paper(scientific journal) Disclose to all
Takashi Shirakawa, Yoshinori Kawazoe, Tomoko Tsujikawa, Dongju Jung, Shin-ichi Sato, Motonari Uesugi Takashi Shirakawa, Yoshinori Kawazoe, Tomoko Tsujikawa, Dongju Jung, Shin-ichi Sato, Motonari Uesugi Takashi Shirakawa, Yoshinori Kawazoe, Tomoko Tsujikawa, Dongju Jung, Shin-ichi Sato, Motonari Uesugi Deactivation of STAT6 through Serine 707 Phosphorylation by JNK Deactivation of STAT6 through Serine 707 Phosphorylation by JNK Deactivation of STAT6 through Serine 707 Phosphorylation by JNK JOURNAL OF BIOLOGICAL CHEMISTRY, 286, 5, 4003-4010 JOURNAL OF BIOLOGICAL CHEMISTRY, 286, 5, 4003-4010 JOURNAL OF BIOLOGICAL CHEMISTRY, 286, 5, 4003-4010 2011/02 Refereed English Research paper(scientific journal) Disclose to all
Shin-ichi Sato, Asako Murata, Tsubasa Orihara, Takashi Shirakawa, Kiyotake Suenaga, Hideo Kigoshi, Motonari Uesugi Shin-ichi Sato, Asako Murata, Tsubasa Orihara, Takashi Shirakawa, Kiyotake Suenaga, Hideo Kigoshi, Motonari Uesugi Shin-ichi Sato, Asako Murata, Tsubasa Orihara, Takashi Shirakawa, Kiyotake Suenaga, Hideo Kigoshi, Motonari Uesugi Marine Natural Product Aurilide Activates the OPA1-Mediated Apoptosis by Binding to Prohibitin Marine Natural Product Aurilide Activates the OPA1-Mediated Apoptosis by Binding to Prohibitin Marine Natural Product Aurilide Activates the OPA1-Mediated Apoptosis by Binding to Prohibitin CHEMISTRY & BIOLOGY, 18, 1, 131-139 CHEMISTRY & BIOLOGY, 18, 1, 131-139 CHEMISTRY & BIOLOGY, 18, 1, 131-139 2011/01 Refereed English Research paper(scientific journal) Disclose to all
Yoshinori Kawazoe, Hiroki Shimogawa, Ayato Sato, Motonari Uesugi Yoshinori Kawazoe, Hiroki Shimogawa, Ayato Sato, Motonari Uesugi Yoshinori Kawazoe, Hiroki Shimogawa, Ayato Sato, Motonari Uesugi A Mitochondrial Surface-Specific Fluorescent Probe Activated by Bioconversion A Mitochondrial Surface-Specific Fluorescent Probe Activated by Bioconversion A Mitochondrial Surface-Specific Fluorescent Probe Activated by Bioconversion ANGEWANDTE CHEMIE-INTERNATIONAL EDITION, 50, 24, 5478-5481 ANGEWANDTE CHEMIE-INTERNATIONAL EDITION, 50, 24, 5478-5481 ANGEWANDTE CHEMIE-INTERNATIONAL EDITION, 50, 24, 5478-5481 2011 Refereed English Research paper(scientific journal) Disclose to all
Asako Murata, Shin-ichi Sato, Yoshinori Kawazoe, Motonari Uesugi Asako Murata, Shin-ichi Sato, Yoshinori Kawazoe, Motonari Uesugi Asako Murata, Shin-ichi Sato, Yoshinori Kawazoe, Motonari Uesugi Small-molecule fluorescent probes for specific RNA targets Small-molecule fluorescent probes for specific RNA targets Small-molecule fluorescent probes for specific RNA targets CHEMICAL COMMUNICATIONS, 47, 16, 4712-4714 CHEMICAL COMMUNICATIONS, 47, 16, 4712-4714 CHEMICAL COMMUNICATIONS, 47, 16, 4712-4714 2011 Refereed English Research paper(scientific journal) Disclose to all
Shin-ichi Sato, Asako Murata, Takashi Shirakawa, Motonari Uesugi Shin-ichi Sato, Asako Murata, Takashi Shirakawa, Motonari Uesugi Shin-ichi Sato, Asako Murata, Takashi Shirakawa, Motonari Uesugi Biochemical Target Isolation for Novices: Affinity-Based Strategies Biochemical Target Isolation for Novices: Affinity-Based Strategies Biochemical Target Isolation for Novices: Affinity-Based Strategies CHEMISTRY & BIOLOGY, 17, 6, 616-623 CHEMISTRY & BIOLOGY, 17, 6, 616-623 CHEMISTRY & BIOLOGY, 17, 6, 616-623 2010/06 Refereed English Disclose to all
S. Yamazoe, H. Shimogawa, S.-i. Sato, J.D. Esko, M. Uesugi S. Yamazoe, H. Shimogawa, S.-i. Sato, J.D. Esko, M. Uesugi S. Yamazoe, H. Shimogawa, S.-i. Sato, J.D. Esko, M. Uesugi A Dumbbell-Shaped Small Molecule that Promotes Cell Adhesion and Growth (DOI:10.1016/j.chembiol.2009.06.008) A Dumbbell-Shaped Small Molecule that Promotes Cell Adhesion and Growth (DOI:10.1016/j.chembiol.2009.06.008) A Dumbbell-Shaped Small Molecule that Promotes Cell Adhesion and Growth (DOI:10.1016/j.chembiol.2009.06.008) Chemistry and Biology, 17, 3, 310- Chemistry and Biology, 17, 3, 310- Chemistry and Biology, 17, 3, 310- 2010 Refereed English Disclose to all
Shinji Kamisuki, Qian Mao, Lutfi Abu-Elheiga, Ziwei Gu, Akira Kugimiya, Youngjoo Kwon, Tokuyuki Shinohara, Yoshinori Kawazoe, Shin-ichi Sato, Koko Asakura, Hea-Young Park Choo, Juro Sakai, Salih J. Wakil, Motonari Uesugi Shinji Kamisuki, Qian Mao, Lutfi Abu-Elheiga, Ziwei Gu, Akira Kugimiya, Youngjoo Kwon, Tokuyuki Shinohara, Yoshinori Kawazoe, Shin-ichi Sato, Koko Asakura, Hea-Young Park Choo, Juro Sakai, Salih J. Wakil, Motonari Uesugi Shinji Kamisuki, Qian Mao, Lutfi Abu-Elheiga, Ziwei Gu, Akira Kugimiya, Youngjoo Kwon, Tokuyuki Shinohara, Yoshinori Kawazoe, Shin-ichi Sato, Koko Asakura, Hea-Young Park Choo, Juro Sakai, Salih J. Wakil, Motonari Uesugi A Small Molecule That Blocks Fat Synthesis By Inhibiting the Activation of SREBP A Small Molecule That Blocks Fat Synthesis By Inhibiting the Activation of SREBP A Small Molecule That Blocks Fat Synthesis By Inhibiting the Activation of SREBP CHEMISTRY & BIOLOGY, 16, 8, 882-892 CHEMISTRY & BIOLOGY, 16, 8, 882-892 CHEMISTRY & BIOLOGY, 16, 8, 882-892 2009/08 Refereed English Research paper(scientific journal) Disclose to all
Sayumi Yamazoe, Hiroki Shimogawa, Shin-ichi Sato, Jeffrey D. Esko, Motonari Uesugi Sayumi Yamazoe, Hiroki Shimogawa, Shin-ichi Sato, Jeffrey D. Esko, Motonari Uesugi Sayumi Yamazoe, Hiroki Shimogawa, Shin-ichi Sato, Jeffrey D. Esko, Motonari Uesugi A Dumbbell-Shaped Small Molecule that Promotes Cell Adhesion and Growth A Dumbbell-Shaped Small Molecule that Promotes Cell Adhesion and Growth A Dumbbell-Shaped Small Molecule that Promotes Cell Adhesion and Growth CHEMISTRY & BIOLOGY, 16, 7, 773-782 CHEMISTRY & BIOLOGY, 16, 7, 773-782 CHEMISTRY & BIOLOGY, 16, 7, 773-782 2009/07 Refereed English Research paper(scientific journal) Disclose to all
Dongju Jung, Hiroki Shimogawa, Youngjoo Kwon, Qian Mao, Shin-ichi Sato, Shinji Kamisuki, Hideo Kigoshi, Motonari Uesugi Dongju Jung, Hiroki Shimogawa, Youngjoo Kwon, Qian Mao, Shin-ichi Sato, Shinji Kamisuki, Hideo Kigoshi, Motonari Uesugi Dongju Jung, Hiroki Shimogawa, Youngjoo Kwon, Qian Mao, Shin-ichi Sato, Shinji Kamisuki, Hideo Kigoshi, Motonari Uesugi Wrenchnolol Derivative Optimized for Gene Activation in Cells Wrenchnolol Derivative Optimized for Gene Activation in Cells Wrenchnolol Derivative Optimized for Gene Activation in Cells JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 131, 13, 4774-4782 JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 131, 13, 4774-4782 JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 131, 13, 4774-4782 2009/04 Refereed English Research paper(scientific journal) Disclose to all
Y. C. Henderson, M. J. Frederick, A. Jayakumar, Y. Choi, M. T. Wang, Y. Kang, R. Evans, P. M. Spring, M. Uesugi, G. L. Clayman Y. C. Henderson, M. J. Frederick, A. Jayakumar, Y. Choi, M. T. Wang, Y. Kang, R. Evans, P. M. Spring, M. Uesugi, G. L. Clayman Y. C. Henderson, M. J. Frederick, A. Jayakumar, Y. Choi, M. T. Wang, Y. Kang, R. Evans, P. M. Spring, M. Uesugi, G. L. Clayman Human LBP-32/MGR is a repressor of the P450scc in human choriocarcinoma cell line JEG-3 Human LBP-32/MGR is a repressor of the P450scc in human choriocarcinoma cell line JEG-3 Human LBP-32/MGR is a repressor of the P450scc in human choriocarcinoma cell line JEG-3 PLACENTA, 28, 2-3, 152-160 PLACENTA, 28, 2-3, 152-160 PLACENTA, 28, 2-3, 152-160 2007/02 English Research paper(scientific journal) Disclose to all
Shin-ichi Sato, Youngjoo Kwon, Shinji Kamisuki, Neeta Srivastava, Qian Mao, Yoshinori Kawazoe, Motonari Uesugi Shin-ichi Sato, Youngjoo Kwon, Shinji Kamisuki, Neeta Srivastava, Qian Mao, Yoshinori Kawazoe, Motonari Uesugi Shin-ichi Sato, Youngjoo Kwon, Shinji Kamisuki, Neeta Srivastava, Qian Mao, Yoshinori Kawazoe, Motonari Uesugi Polyproline-rod approach to isolating protein targets of bioactive small molecules: Isolation of a new target of indomethacin Polyproline-rod approach to isolating protein targets of bioactive small molecules: Isolation of a new target of indomethacin Polyproline-rod approach to isolating protein targets of bioactive small molecules: Isolation of a new target of indomethacin JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 129, 4, 873-880 JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 129, 4, 873-880 JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 129, 4, 873-880 2007/01 Refereed English Research paper(scientific journal) Disclose to all
DJ Jung, YM Choi, M Uesugi DJ Jung, YM Choi, M Uesugi DJ Jung, YM Choi, M Uesugi Small organic molecules that modulate gene transcription Small organic molecules that modulate gene transcription Small organic molecules that modulate gene transcription DRUG DISCOVERY TODAY, 11, 9-10, 452-457 DRUG DISCOVERY TODAY, 11, 9-10, 452-457 DRUG DISCOVERY TODAY, 11, 9-10, 452-457 2006/05 Refereed English Disclose to all
YM Choi, H Shimogawa, K Murakami, L Ramdas, W Zhang, J Qin, M Uesugi YM Choi, H Shimogawa, K Murakami, L Ramdas, W Zhang, J Qin, M Uesugi YM Choi, H Shimogawa, K Murakami, L Ramdas, W Zhang, J Qin, M Uesugi Chemical genetic identification of the IGF-linked pathway that is mediated by STAT6 and MFP2 Chemical genetic identification of the IGF-linked pathway that is mediated by STAT6 and MFP2 Chemical genetic identification of the IGF-linked pathway that is mediated by STAT6 and MFP2 CHEMISTRY & BIOLOGY, 13, 3, 241-249 CHEMISTRY & BIOLOGY, 13, 3, 241-249 CHEMISTRY & BIOLOGY, 13, 3, 241-249 2006/03 Refereed English Research paper(scientific journal) Disclose to all
Y Kwonj, HD Arndt, M Qian, Y Choi, Y Kawazoe, PB Dervan, M Uesugi Y Kwonj, HD Arndt, M Qian, Y Choi, Y Kawazoe, PB Dervan, M Uesugi Y Kwonj, HD Arndt, M Qian, Y Choi, Y Kawazoe, PB Dervan, M Uesugi Small molecule transcription factor mimic Small molecule transcription factor mimic Small molecule transcription factor mimic JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 126, 49, 15940-15941 JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 126, 49, 15940-15941 JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 126, 49, 15940-15941 2004/12 Refereed English Research paper(scientific journal) Disclose to all
Y Kawazoe, S Tanaka, M Uesugi Y Kawazoe, S Tanaka, M Uesugi Y Kawazoe, S Tanaka, M Uesugi Chemical genetic identification of the histamine H1 receptor as a stimulator of insulin-induced adipogenesis Chemical genetic identification of the histamine H1 receptor as a stimulator of insulin-induced adipogenesis Chemical genetic identification of the histamine H1 receptor as a stimulator of insulin-induced adipogenesis CHEMISTRY & BIOLOGY, 11, 7, 907-913 CHEMISTRY & BIOLOGY, 11, 7, 907-913 CHEMISTRY & BIOLOGY, 11, 7, 907-913 2004/07 Refereed English Research paper(scientific journal) Disclose to all
Y Choi, M Uesugi Y Choi, M Uesugi Y Choi, M Uesugi Regulation of IGF2 functions by a bioactive small molecule Regulation of IGF2 functions by a bioactive small molecule Regulation of IGF2 functions by a bioactive small molecule FASEB JOURNAL, 18, 8, C219-C219 FASEB JOURNAL, 18, 8, C219-C219 FASEB JOURNAL, 18, 8, C219-C219 2004/05 English Disclose to all
H Shimogawa, Y Kwon, Q Mao, Y Kawazoe, Y Choi, S Asada, H Kigoshi, M Uesugi H Shimogawa, Y Kwon, Q Mao, Y Kawazoe, Y Choi, S Asada, H Kigoshi, M Uesugi H Shimogawa, Y Kwon, Q Mao, Y Kawazoe, Y Choi, S Asada, H Kigoshi, M Uesugi A wrench-shaped synthetic molecule that modulates a transcription factor - Coactivator interaction A wrench-shaped synthetic molecule that modulates a transcription factor - Coactivator interaction A wrench-shaped synthetic molecule that modulates a transcription factor - Coactivator interaction JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 126, 11, 3461-3471 JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 126, 11, 3461-3471 JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 126, 11, 3461-3471 2004/03 Refereed English Research paper(scientific journal) Disclose to all
S Asada, YM Choi, M Uesugi S Asada, YM Choi, M Uesugi S Asada, YM Choi, M Uesugi A gene-expression inhibitor that targets an alpha-helix-mediated protein interaction A gene-expression inhibitor that targets an alpha-helix-mediated protein interaction A gene-expression inhibitor that targets an alpha-helix-mediated protein interaction JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 125, 17, 4992-4993 JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 125, 17, 4992-4993 JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 125, 17, 4992-4993 2003/04 Refereed English Research paper(scientific journal) Disclose to all
YM Choi, Y Kawazoe, K Murakami, H Misawa, M Uesugi YM Choi, Y Kawazoe, K Murakami, H Misawa, M Uesugi YM Choi, Y Kawazoe, K Murakami, H Misawa, M Uesugi Identification of bioactive molecules by adipogenesis profiling of organic compounds Identification of bioactive molecules by adipogenesis profiling of organic compounds Identification of bioactive molecules by adipogenesis profiling of organic compounds JOURNAL OF BIOLOGICAL CHEMISTRY, 278, 9, 7320-7324 JOURNAL OF BIOLOGICAL CHEMISTRY, 278, 9, 7320-7324 JOURNAL OF BIOLOGICAL CHEMISTRY, 278, 9, 7320-7324 2003/02 Refereed English Research paper(scientific journal) Disclose to all
Jabbur, JR, AD Tabor, XD Cheng, H Wang, M Uesugi, G Lozano, W Zhang Jabbur, JR, AD Tabor, XD Cheng, H Wang, M Uesugi, G Lozano, W Zhang Jabbur, JR, AD Tabor, XD Cheng, H Wang, M Uesugi, G Lozano, W Zhang Mdm-2 binding and TAF(II)31 recruitment is regulated by hydrogen bond disruption between the p53 residues Thr18 and Asp21 Mdm-2 binding and TAF(II)31 recruitment is regulated by hydrogen bond disruption between the p53 residues Thr18 and Asp21 Mdm-2 binding and TAF(II)31 recruitment is regulated by hydrogen bond disruption between the p53 residues Thr18 and Asp21 ONCOGENE, 21, 46, 7100-7113 ONCOGENE, 21, 46, 7100-7113 ONCOGENE, 21, 46, 7100-7113 2002/10 Refereed English Research paper(scientific journal) Disclose to all
Y Choi, S Asada, M Uesugi Y Choi, S Asada, M Uesugi Y Choi, S Asada, M Uesugi Divergent hTAF(II)31-binding motifs hidden in activation domains Divergent hTAF(II)31-binding motifs hidden in activation domains Divergent hTAF(II)31-binding motifs hidden in activation domains JOURNAL OF BIOLOGICAL CHEMISTRY, 275, 21, 15912-15916 JOURNAL OF BIOLOGICAL CHEMISTRY, 275, 21, 15912-15916 JOURNAL OF BIOLOGICAL CHEMISTRY, 275, 21, 15912-15916 2000/05 Refereed English Research paper(scientific journal) Disclose to all
SJ Park, M Uesugi, LJ Sun, GR Crabtree, GL Verdine SJ Park, M Uesugi, LJ Sun, GR Crabtree, GL Verdine SJ Park, M Uesugi, LJ Sun, GR Crabtree, GL Verdine Existence of a second calcineurin binding site on select isoforms of NFAT Existence of a second calcineurin binding site on select isoforms of NFAT Existence of a second calcineurin binding site on select isoforms of NFAT FASEB JOURNAL, 13, 7, A1495-A1495 FASEB JOURNAL, 13, 7, A1495-A1495 FASEB JOURNAL, 13, 7, A1495-A1495 1999/04 English Disclose to all
M Uesugi, O Nyanguile, H Lu, AJ Levine, GL Verdine M Uesugi, O Nyanguile, H Lu, AJ Levine, GL Verdine M Uesugi, O Nyanguile, H Lu, AJ Levine, GL Verdine Induced alpha helix in the VP16 activation domain upon binding to a human TAF Induced alpha helix in the VP16 activation domain upon binding to a human TAF Induced alpha helix in the VP16 activation domain upon binding to a human TAF SCIENCE, 277, 5330, 1310-1313 SCIENCE, 277, 5330, 1310-1313 SCIENCE, 277, 5330, 1310-1313 1997/08 Refereed English Research paper(scientific journal) Disclose to all
T KUSAKABE, M UESUGI, Y SUGIURA T KUSAKABE, M UESUGI, Y SUGIURA T KUSAKABE, M UESUGI, Y SUGIURA SEQUENCE PREFERENCE FOR STRAND CLEAVAGE OF GAPPED DUPLEXES BY DYNEMICIN-A - POSSIBLE MECHANISM OF SEQUENCE-DEPENDENT DOUBLE-STRANDED BREAKS SEQUENCE PREFERENCE FOR STRAND CLEAVAGE OF GAPPED DUPLEXES BY DYNEMICIN-A - POSSIBLE MECHANISM OF SEQUENCE-DEPENDENT DOUBLE-STRANDED BREAKS SEQUENCE PREFERENCE FOR STRAND CLEAVAGE OF GAPPED DUPLEXES BY DYNEMICIN-A - POSSIBLE MECHANISM OF SEQUENCE-DEPENDENT DOUBLE-STRANDED BREAKS BIOCHEMISTRY, 34, 31, 9944-9950 BIOCHEMISTRY, 34, 31, 9944-9950 BIOCHEMISTRY, 34, 31, 9944-9950 1995/08 Refereed English Research paper(scientific journal) Disclose to all
M UESUGI, T KUSAKABE, Y SUGIURA M UESUGI, T KUSAKABE, Y SUGIURA M UESUGI, T KUSAKABE, Y SUGIURA HYDROPHOBIC DNA-BINDING OF ESPERAMICIN REQUIRES CONFORMATIONAL DISTORTION OF THE HOST DNA HYDROPHOBIC DNA-BINDING OF ESPERAMICIN REQUIRES CONFORMATIONAL DISTORTION OF THE HOST DNA HYDROPHOBIC DNA-BINDING OF ESPERAMICIN REQUIRES CONFORMATIONAL DISTORTION OF THE HOST DNA BIOCHIMICA ET BIOPHYSICA ACTA-GENE STRUCTURE AND EXPRESSION, 1261, 1, 99-106 BIOCHIMICA ET BIOPHYSICA ACTA-GENE STRUCTURE AND EXPRESSION, 1261, 1, 99-106 BIOCHIMICA ET BIOPHYSICA ACTA-GENE STRUCTURE AND EXPRESSION, 1261, 1, 99-106 1995/03 Refereed English Research paper(scientific journal) Disclose to all
R TOTSUKA, Y AIZAWA, M UESUGI, Y OKUNO, T MATSUMOTO, Y SUGIURA R TOTSUKA, Y AIZAWA, M UESUGI, Y OKUNO, T MATSUMOTO, Y SUGIURA R TOTSUKA, Y AIZAWA, M UESUGI, Y OKUNO, T MATSUMOTO, Y SUGIURA RNA CLEAVAGE BY C-1027 CHROMOPHORE, AN ENEDIYNE ANTITUMOR ANTIBIOTIC - HIGH SELECTIVITY TO AN ANTICODON ARM RNA CLEAVAGE BY C-1027 CHROMOPHORE, AN ENEDIYNE ANTITUMOR ANTIBIOTIC - HIGH SELECTIVITY TO AN ANTICODON ARM RNA CLEAVAGE BY C-1027 CHROMOPHORE, AN ENEDIYNE ANTITUMOR ANTIBIOTIC - HIGH SELECTIVITY TO AN ANTICODON ARM BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 208, 1, 168-173 BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 208, 1, 168-173 BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 208, 1, 168-173 1995/03 Refereed English Research paper(scientific journal) Disclose to all
T KUSHIDA, M UESUGI, Y SUGIURA, H KIGOSHI, H TANAKA, J HIROKAWA, M OJIKA, K YAMADA T KUSHIDA, M UESUGI, Y SUGIURA, H KIGOSHI, H TANAKA, J HIROKAWA, M OJIKA, K YAMADA T KUSHIDA, M UESUGI, Y SUGIURA, H KIGOSHI, H TANAKA, J HIROKAWA, M OJIKA, K YAMADA DNA-DAMAGE BY PTAQUILOSIDE, A POTENT BRACKEN CARCINOGEN - DETECTION OF SELECTIVE STRAND BREAKS AND IDENTIFICATION OF DNA CLEAVAGE PRODUCTS DNA-DAMAGE BY PTAQUILOSIDE, A POTENT BRACKEN CARCINOGEN - DETECTION OF SELECTIVE STRAND BREAKS AND IDENTIFICATION OF DNA CLEAVAGE PRODUCTS DNA-DAMAGE BY PTAQUILOSIDE, A POTENT BRACKEN CARCINOGEN - DETECTION OF SELECTIVE STRAND BREAKS AND IDENTIFICATION OF DNA CLEAVAGE PRODUCTS JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 116, 2, 479-486 JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 116, 2, 479-486 JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 116, 2, 479-486 1994/01 Refereed English Research paper(scientific journal) Disclose to all
T KUSAKABE, K MAEKAWA, A ICHIKAWA, M UESUGI, Y SUGIURA T KUSAKABE, K MAEKAWA, A ICHIKAWA, M UESUGI, Y SUGIURA T KUSAKABE, K MAEKAWA, A ICHIKAWA, M UESUGI, Y SUGIURA CONFORMATION-SELECTIVE DNA STRAND BREAKS BY DYNEMICIN - A MOLECULAR WEDGE INTO FLEXIBLE REGIONS OF DNA CONFORMATION-SELECTIVE DNA STRAND BREAKS BY DYNEMICIN - A MOLECULAR WEDGE INTO FLEXIBLE REGIONS OF DNA CONFORMATION-SELECTIVE DNA STRAND BREAKS BY DYNEMICIN - A MOLECULAR WEDGE INTO FLEXIBLE REGIONS OF DNA BIOCHEMISTRY, 32, 43, 11669-11675 BIOCHEMISTRY, 32, 43, 11669-11675 BIOCHEMISTRY, 32, 43, 11669-11675 1993/11 Refereed English Research paper(scientific journal) Disclose to all
M UESUGI, Y SUGIURA M UESUGI, Y SUGIURA M UESUGI, Y SUGIURA NEW INSIGHTS INTO SEQUENCE RECOGNITION PROCESS OF ESPERAMICIN-A(1) AND CALICHEAMICIN-GAMMA-1(I) - ORIGIN OF THEIR SELECTIVITIES AND INDUCED FIT MECHANISM NEW INSIGHTS INTO SEQUENCE RECOGNITION PROCESS OF ESPERAMICIN-A(1) AND CALICHEAMICIN-GAMMA-1(I) - ORIGIN OF THEIR SELECTIVITIES AND INDUCED FIT MECHANISM NEW INSIGHTS INTO SEQUENCE RECOGNITION PROCESS OF ESPERAMICIN-A(1) AND CALICHEAMICIN-GAMMA-1(I) - ORIGIN OF THEIR SELECTIVITIES AND INDUCED FIT MECHANISM BIOCHEMISTRY, 32, 17, 4622-4627 BIOCHEMISTRY, 32, 17, 4622-4627 BIOCHEMISTRY, 32, 17, 4622-4627 1993/05 Refereed English Research paper(scientific journal) Disclose to all
M TOKUDA, K FUJIWARA, T GOMIBUCHI, M HIRAMA, M UESUGI, Y SUGIURA M TOKUDA, K FUJIWARA, T GOMIBUCHI, M HIRAMA, M UESUGI, Y SUGIURA M TOKUDA, K FUJIWARA, T GOMIBUCHI, M HIRAMA, M UESUGI, Y SUGIURA SYNTHESIS OF A HYBRID MOLECULE CONTAINING NEOCARZINOSTATIN CHROMOPHORE ANALOG AND MINOR GROOVE BINDER SYNTHESIS OF A HYBRID MOLECULE CONTAINING NEOCARZINOSTATIN CHROMOPHORE ANALOG AND MINOR GROOVE BINDER SYNTHESIS OF A HYBRID MOLECULE CONTAINING NEOCARZINOSTATIN CHROMOPHORE ANALOG AND MINOR GROOVE BINDER TETRAHEDRON LETTERS, 34, 4, 669-672 TETRAHEDRON LETTERS, 34, 4, 669-672 TETRAHEDRON LETTERS, 34, 4, 669-672 1993/01 Refereed English Research paper(scientific journal) Disclose to all
T SHIRAKI, M UESUGI, Y SUGIURA T SHIRAKI, M UESUGI, Y SUGIURA T SHIRAKI, M UESUGI, Y SUGIURA C-1' HYDROGEN ABSTRACTION OF DEOXYRIBOSE IN DNA STRAND SCISSION BY DYNEMICIN-A C-1' HYDROGEN ABSTRACTION OF DEOXYRIBOSE IN DNA STRAND SCISSION BY DYNEMICIN-A C-1' HYDROGEN ABSTRACTION OF DEOXYRIBOSE IN DNA STRAND SCISSION BY DYNEMICIN-A BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 188, 2, 584-589 BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 188, 2, 584-589 BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 188, 2, 584-589 1992/10 Refereed English Research paper(scientific journal) Disclose to all
M UESUGI, Y SUGIURA M UESUGI, Y SUGIURA M UESUGI, Y SUGIURA PRODUCT ANALYSES IN DNA STRAND SCISSION BY ANTITUMOR ANTIBIOTIC ELSAMICIN-A PRODUCT ANALYSES IN DNA STRAND SCISSION BY ANTITUMOR ANTIBIOTIC ELSAMICIN-A PRODUCT ANALYSES IN DNA STRAND SCISSION BY ANTITUMOR ANTIBIOTIC ELSAMICIN-A BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 186, 1, 580-587 BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 186, 1, 580-587 BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 186, 1, 580-587 1992/07 Refereed English Research paper(scientific journal) Disclose to all
T OWA, A HAUPT, M OTSUKA, S KOBAYASHI, N TOMIOKA, A ITAI, M OHNO, T SHIRAKI, M UESUGI, Y SUGIURA, K MAEDA T OWA, A HAUPT, M OTSUKA, S KOBAYASHI, N TOMIOKA, A ITAI, M OHNO, T SHIRAKI, M UESUGI, Y SUGIURA, K MAEDA T OWA, A HAUPT, M OTSUKA, S KOBAYASHI, N TOMIOKA, A ITAI, M OHNO, T SHIRAKI, M UESUGI, Y SUGIURA, K MAEDA MAN-DESIGNED BLEOMYCINS - SIGNIFICANCE OF THE BINDING-SITES AS ENZYME MODELS AND OF THE STEREOCHEMISTRY OF THE LINKER MOIETY MAN-DESIGNED BLEOMYCINS - SIGNIFICANCE OF THE BINDING-SITES AS ENZYME MODELS AND OF THE STEREOCHEMISTRY OF THE LINKER MOIETY MAN-DESIGNED BLEOMYCINS - SIGNIFICANCE OF THE BINDING-SITES AS ENZYME MODELS AND OF THE STEREOCHEMISTRY OF THE LINKER MOIETY TETRAHEDRON, 48, 7, 1193-1208 TETRAHEDRON, 48, 7, 1193-1208 TETRAHEDRON, 48, 7, 1193-1208 1992/02 Refereed English Research paper(scientific journal) Disclose to all
M HIRAMA, T GOMIBUCHI, K FUJIWARA, Y SUGIURA, M UESUGI M HIRAMA, T GOMIBUCHI, K FUJIWARA, Y SUGIURA, M UESUGI M HIRAMA, T GOMIBUCHI, K FUJIWARA, Y SUGIURA, M UESUGI SYNTHESIS AND DNA-CLEAVING ABILITIES OF FUNCTIONAL NEOCARZINOSTATIN CHROMOPHORE ANALOGS - BASE DISCRIMINATION BY A SIMPLE ALCOHOL SYNTHESIS AND DNA-CLEAVING ABILITIES OF FUNCTIONAL NEOCARZINOSTATIN CHROMOPHORE ANALOGS - BASE DISCRIMINATION BY A SIMPLE ALCOHOL SYNTHESIS AND DNA-CLEAVING ABILITIES OF FUNCTIONAL NEOCARZINOSTATIN CHROMOPHORE ANALOGS - BASE DISCRIMINATION BY A SIMPLE ALCOHOL JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 113, 26, 9851-9853 JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 113, 26, 9851-9853 JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 113, 26, 9851-9853 1991/12 Refereed English Disclose to all
M UESUGI, T SEKIDA, S MATSUKI, Y SUGIURA M UESUGI, T SEKIDA, S MATSUKI, Y SUGIURA M UESUGI, T SEKIDA, S MATSUKI, Y SUGIURA SELECTIVE DNA CLEAVAGE BY ELSAMICIN-A AND SWITCH FUNCTION OF ITS AMINO SUGAR GROUP SELECTIVE DNA CLEAVAGE BY ELSAMICIN-A AND SWITCH FUNCTION OF ITS AMINO SUGAR GROUP SELECTIVE DNA CLEAVAGE BY ELSAMICIN-A AND SWITCH FUNCTION OF ITS AMINO SUGAR GROUP BIOCHEMISTRY, 30, 27, 6711-6715 BIOCHEMISTRY, 30, 27, 6711-6715 BIOCHEMISTRY, 30, 27, 6711-6715 1991/07 English Research paper(scientific journal) Disclose to all
Y SUGIURA, T ARAKAWA, M UESUGI, T SHIRAKI, H OHKUMA, M KONISHI Y SUGIURA, T ARAKAWA, M UESUGI, T SHIRAKI, H OHKUMA, M KONISHI Y SUGIURA, T ARAKAWA, M UESUGI, T SHIRAKI, H OHKUMA, M KONISHI REDUCTIVE AND NUCLEOPHILIC ACTIVATION PRODUCTS OF DYNEMICIN-A WITH METHYL THIOGLYCOLATE - A RATIONAL MECHANISM FOR DNA CLEAVAGE OF THE THIOL-ACTIVATED DYNEMICIN-A REDUCTIVE AND NUCLEOPHILIC ACTIVATION PRODUCTS OF DYNEMICIN-A WITH METHYL THIOGLYCOLATE - A RATIONAL MECHANISM FOR DNA CLEAVAGE OF THE THIOL-ACTIVATED DYNEMICIN-A REDUCTIVE AND NUCLEOPHILIC ACTIVATION PRODUCTS OF DYNEMICIN-A WITH METHYL THIOGLYCOLATE - A RATIONAL MECHANISM FOR DNA CLEAVAGE OF THE THIOL-ACTIVATED DYNEMICIN-A BIOCHEMISTRY, 30, 12, 2989-2992 BIOCHEMISTRY, 30, 12, 2989-2992 BIOCHEMISTRY, 30, 12, 2989-2992 1991/03 Refereed English Research paper(scientific journal) Disclose to all
Uesugi, M Uesugi, M Uesugi, M Small Molecule Tools for Cell Biology and Cell Therapy Small Molecule Tools for Cell Biology and Cell Therapy Small Molecule Tools for Cell Biology and Cell Therapy Chembiomolecular Science at the Frontier of Chemistry and Biology , 51-58 Chembiomolecular Science at the Frontier of Chemistry and Biology , 51-58 Chembiomolecular Science at the Frontier of Chemistry and Biology , 51-58 Disclose to all

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Title language:
Misc
Author Author(Japanese) Author(English) Title Title(Japanese) Title(English) Bibliography Bibliography(Japanese) Bibliography(English) Publication date Refereed paper Language Publishing type Disclose
Junichiro Takaya, Motonari Uesugi Junichiro Takaya, Motonari Uesugi Junichiro Takaya, Motonari Uesugi Chemical Biological Analysis of TRPA1 Activation Mechanism Chemical Biological Analysis of TRPA1 Activation Mechanism Chemical Biological Analysis of TRPA1 Activation Mechanism JOURNAL OF SYNTHETIC ORGANIC CHEMISTRY JAPAN, 74, 5, 505-511 JOURNAL OF SYNTHETIC ORGANIC CHEMISTRY JAPAN, 74, 5, 505-511 JOURNAL OF SYNTHETIC ORGANIC CHEMISTRY JAPAN, 74, 5, 505-511 2016/05 Japanese Book review and document introduction, etc. Disclose to all
Lutfi Abu-Elheiga, Motonari Uesugi, Salih Wakil Lutfi Abu-Elheiga, Motonari Uesugi, Salih Wakil Lutfi Abu-Elheiga, Motonari Uesugi, Salih Wakil Regulation of de novo lipid synthesis by small organic molecules, fatostatins Regulation of de novo lipid synthesis by small organic molecules, fatostatins Regulation of de novo lipid synthesis by small organic molecules, fatostatins FASEB JOURNAL, 25 FASEB JOURNAL, 25 FASEB JOURNAL, 25 2011/04 English Summary of the papers read (international conference) Disclose to all
Gaku Murakami, Haruhisa Inoue, Kayoko Tsukita, Yasuyuki Asai, Yuji Amagai, Kazuhiro Aiba, Hiroki Shimogawa, Motonari Uesugi, Norio Nakatsuji, Ryosuke Takahashi Gaku Murakami, Haruhisa Inoue, Kayoko Tsukita, Yasuyuki Asai, Yuji Amagai, Kazuhiro Aiba, Hiroki Shimogawa, Motonari Uesugi, Norio Nakatsuji, Ryosuke Takahashi Gaku Murakami, Haruhisa Inoue, Kayoko Tsukita, Yasuyuki Asai, Yuji Amagai, Kazuhiro Aiba, Hiroki Shimogawa, Motonari Uesugi, Norio Nakatsuji, Ryosuke Takahashi Chemical library screening identifies a small molecule that downregulates SOD1 transcription for drugs to treat amyotrophic lateral sclerosis Chemical library screening identifies a small molecule that downregulates SOD1 transcription for drugs to treat amyotrophic lateral sclerosis Chemical library screening identifies a small molecule that downregulates SOD1 transcription for drugs to treat amyotrophic lateral sclerosis NEUROSCIENCE RESEARCH, 71, E55-E55 NEUROSCIENCE RESEARCH, 71, E55-E55 NEUROSCIENCE RESEARCH, 71, E55-E55 2011 English Summary of the papers read (international conference) Disclose to all
Sayumi Yamazoe, Hiroki Shimogawa, Shin-ichi Sato, Jeffrey D. Esko, Motonari Uesugi Sayumi Yamazoe, Hiroki Shimogawa, Shin-ichi Sato, Jeffrey D. Esko, Motonari Uesugi Sayumi Yamazoe, Hiroki Shimogawa, Shin-ichi Sato, Jeffrey D. Esko, Motonari Uesugi A Dumbbell-Shaped Small Molecule that Promotes Cell Adhesion and Growth (vol 16, pg 773, 2009) A Dumbbell-Shaped Small Molecule that Promotes Cell Adhesion and Growth (vol 16, pg 773, 2009) A Dumbbell-Shaped Small Molecule that Promotes Cell Adhesion and Growth (vol 16, pg 773, 2009) CHEMISTRY & BIOLOGY, 17, 3, 310-310 CHEMISTRY & BIOLOGY, 17, 3, 310-310 CHEMISTRY & BIOLOGY, 17, 3, 310-310 2010/03 English Other article Disclose to all
Gaku Murakami, Haruhisa Inoue, Kayoko Tsukita, Yasuyuki Asai, Kazuhiro Aiba, Yuji Amagai, Motonari Uesugi, Norio Nakatsuji, Ryosuke Takahashi Gaku Murakami, Haruhisa Inoue, Kayoko Tsukita, Yasuyuki Asai, Kazuhiro Aiba, Yuji Amagai, Motonari Uesugi, Norio Nakatsuji, Ryosuke Takahashi Gaku Murakami, Haruhisa Inoue, Kayoko Tsukita, Yasuyuki Asai, Kazuhiro Aiba, Yuji Amagai, Motonari Uesugi, Norio Nakatsuji, Ryosuke Takahashi A high-throughput screening assay for drug discovery in SOD1-mediated ALS targeting the transcription of SOD1 A high-throughput screening assay for drug discovery in SOD1-mediated ALS targeting the transcription of SOD1 A high-throughput screening assay for drug discovery in SOD1-mediated ALS targeting the transcription of SOD1 NEUROSCIENCE RESEARCH, 68, E311-E311 NEUROSCIENCE RESEARCH, 68, E311-E311 NEUROSCIENCE RESEARCH, 68, E311-E311 2010 English Summary of the papers read (international conference) Disclose to all
Gaku Murakami, Haruhisa Inoue, Kayoko Tsukita, Yasuyuki Asai, Kazuhiro Aiba, Yuji Amagai, Motonari Uesugi, Norio Nakatsuji, Ryosuke Takahashi Gaku Murakami, Haruhisa Inoue, Kayoko Tsukita, Yasuyuki Asai, Kazuhiro Aiba, Yuji Amagai, Motonari Uesugi, Norio Nakatsuji, Ryosuke Takahashi Gaku Murakami, Haruhisa Inoue, Kayoko Tsukita, Yasuyuki Asai, Kazuhiro Aiba, Yuji Amagai, Motonari Uesugi, Norio Nakatsuji, Ryosuke Takahashi Development of a high-throughput screening assay for drug discovery in SOD1-mediated ALS Development of a high-throughput screening assay for drug discovery in SOD1-mediated ALS Development of a high-throughput screening assay for drug discovery in SOD1-mediated ALS NEUROSCIENCE RESEARCH, 65, S120-S120 NEUROSCIENCE RESEARCH, 65, S120-S120 NEUROSCIENCE RESEARCH, 65, S120-S120 2009 English Summary of the papers read (international conference) Disclose to all
Y Kwon, H Shimogawa, Q Mao, Y Kawazoe, YM Choi, H Kigoshi, M Uesugi Y Kwon, H Shimogawa, Q Mao, Y Kawazoe, YM Choi, H Kigoshi, M Uesugi Y Kwon, H Shimogawa, Q Mao, Y Kawazoe, YM Choi, H Kigoshi, M Uesugi Wrench-shaped synthetic molecules that modulate gene transcription. Wrench-shaped synthetic molecules that modulate gene transcription. Wrench-shaped synthetic molecules that modulate gene transcription. ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY, 228, U909-U909 ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY, 228, U909-U909 ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY, 228, U909-U909 2004/08 English Summary of the papers read (international conference) Disclose to all
Y Choi, Y Kawazoe, K Murakami, M Uesugi Y Choi, Y Kawazoe, K Murakami, M Uesugi Y Choi, Y Kawazoe, K Murakami, M Uesugi Identification of bioactive molecules by adipogenesis profiling of organic compounds Identification of bioactive molecules by adipogenesis profiling of organic compounds Identification of bioactive molecules by adipogenesis profiling of organic compounds FASEB JOURNAL, 17, 4, A605-A605 FASEB JOURNAL, 17, 4, A605-A605 FASEB JOURNAL, 17, 4, A605-A605 2003/03 English Summary of the papers read (international conference) Disclose to all
Title language:
Books etc
Author Author(Japanese) Author(English) Title Title(Japanese) Title(English) Publisher Publisher(Japanese) Publisher(English) Publication date Language Type Disclose
日本学術振興会ケミカルバイオロジ, 委員会 日本学術振興会ケミカルバイオロジ, 委員会 ケミカルバイオロジー化合物集 研究展開のヒント ケミカルバイオロジー化合物集 研究展開のヒント オーム社 オーム社 2018/10 Other Disclose to all
上杉 志成 上杉 志成 京都大学 アイデアが湧いてくる講義 サイエンスの発想法 京都大学 アイデアが湧いてくる講義 サイエンスの発想法 祥伝社黄金文庫 祥伝社黄金文庫 2017/09 Single Work Disclose to all
上杉志成 上杉志成 京都大学人気講義 サイエンスの発想法 京都大学人気講義 サイエンスの発想法 祥伝社 祥伝社 2014/04/30 Single Work Disclose to all
長野 哲雄, 菊地 和也, 上杉 志成, 長田 裕之 長野 哲雄, 菊地 和也, 上杉 志成, 長田 裕之 ケミカルバイオロジー ケミカルバイオロジー 共立出版 共立出版 2008/05 Joint Editor Disclose to all
長野哲雄, 長田裕之, 菊地和也, 上杉志成, 共立出版 長野哲雄, 長田裕之, 菊地和也, 上杉志成, 共立出版 ケミカルバイオロジー PNE 蛋白質 核酸 酵素 2007年10月号増刊 ケミカルバイオロジー PNE 蛋白質 核酸 酵素 2007年10月号増刊 共立出版 共立出版 2007 Joint Work Disclose to all
長野哲雄, 長田裕之, 菊地和也, 上杉志成, 共立出版 長野哲雄, 長田裕之, 菊地和也, 上杉志成, 共立出版 ゲノムサイエンスの新たなる挑戦 PNE 蛋白質 核酸 酵素 2001年12月号増刊 ゲノムサイエンスの新たなる挑戦 PNE 蛋白質 核酸 酵素 2001年12月号増刊 共立出版 共立出版 2001 Joint Work Disclose to all
Title language:
Awards
Title(Japanese) Title(English) Organization name(Japanese) Organization name(English) Date
若手研究奨励賞 Lymphoma Research Foundation アメリカリンパ腫研究財団 Young Investigator Award 2001/07/
若手研究奨励賞 Research Scholar Award アメリカ癌財団 American Cancer Society 2003/07/
ゴールドメダル賞 Gold Medal Award 東京テクノフォーラム21 Tokyo Techno-Forum 2006/04/
学術振興賞  Award for Divisional Scientific Promotions 日本薬学会 The Pharmaceutical Society of Japan 2011/03/
ドイツ イノベーションアワード ゴットフリード・ワグネル賞 2010 (1等) German Innovation Award Gottfried Wagener Prize 2010 (1st Prize)  ドイツ 科学・イノベーション フォーラム東京、在日ドイツ商工会議所 German Research and Innovation Forum Tokyo & German Chamber of Commerce and Industry in Japan 2011/05/
第49回市村学術賞貢献賞 The 49th Ichimura Prize in Science for Distinguished Achievement 公益財団法人新技術開発財団 The New Technology Development Foundation 2017/04/26
External funds: competitive funds and Grants-in-Aid for Scientific Research (Kakenhi)
Type Position Title(Japanese) Title(English) Period
基盤研究(B) Representative 小分子有機化合物を起爆剤とした細胞シグナル解析 2009/04/01-2011/03/31
挑戦的萌芽研究 Representative 転写因子Hes1の振動を制御する小分子化合物 (平成26年度分) 2014/04/01-2015/03/31
新学術領域研究(研究領域提案型) Representative 脂質関連内因性分子の新機能発掘と調節 (平成26年度分) 2014/04/01-2015/03/31
基盤研究(S) Representative 合成小分子化合物による細胞の操作と分析 (平成26年度分) 2014/05/30-2015/03/31
基盤研究(S) Representative 合成小分子化合物による細胞の操作と分析 (平成27年度分) 2015/04/01-2016/03/31
挑戦的萌芽研究 Representative 転写因子Hes1の振動を制御する小分子化合物 (平成27年度分) 2015/04/01-2016/03/31
新学術領域研究(研究領域提案型) Representative 脂質関連内因性分子の新機能発掘と調節 (平成27年度分) 2015/04/01-2016/03/31
基盤研究(S) Representative 合成小分子化合物による細胞の操作と分析 (平成28年度分) 2016/04/01-2017/03/31
特別研究員奨励費 Representative RNAのGグアドルプレックスを認識する化合物の開発と利用 (平成28年度分) 2016/04/01-2017/03/31
挑戦的研究(萌芽) Representative 人工翻訳後修飾 (平成29年度分) 2017/04/01-2018/03/31
基盤研究(S) Representative 合成小分子化合物による細胞の操作と分析 (平成29年度分) 2017/04/01-2018/03/31
新学術領域研究(研究領域提案型) Representative 人工栄養素結合体の化学シグナル (平成29年度分) 2017/04/01-2018/03/31
特別研究員奨励費 Representative RNAのGグアドルプレックスを認識する化合物の開発と利用 (平成29年度分) 2017/04/01-2018/03/31
挑戦的研究(萌芽) Representative 人工翻訳後修飾 (平成30年度分) 2018/04/01-2019/03/31
基盤研究(S) Representative 合成小分子化合物による細胞の操作と分析 (平成30年度分) 2018/04/01-2019/03/31
新学術領域研究(研究領域提案型) Representative 人工栄養素結合体の化学シグナル (平成30年度分) 2018/04/01-2019/03/31
基盤研究(A) Representative 自己集合性生理活性小分子の開拓 (2019年度分) 2019/04/01-2020/03/31
新学術領域研究(研究領域提案型) Representative 人工栄養素結合体の化学シグナル (2019年度分) 2019/04/01-2020/03/31

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External funds: other than those above
System Main person Title(Japanese) Title(English) Period
独立行政法人科学技術振興機構 戦略的創造研究推進事業 さきがけ 上杉 志成 生命現象分析のための小分子転写因子創成 2005/10/-2009/03/
独立行政法人科学技術振興機構 研究成果最適展開支援事業(A-STEP)フィージビリティスタディ 上杉 志成 細胞接着促進化合物の実用化 2009/11/01-2010/10/31
独立行政法人日本学術振興会 最先端・次世代研究開発支援プログラム 上杉 志成 合成小分子化合物による細胞の操作と分析(H23-26) Control and Analysis of Cells by Synthetic Small Molecules 2011/02/-2014/03/31
独立行政法人日本学術振興会 アジア研究教育拠点事業 上杉 志成 アジア発ケミカルバイオロジー(H23-27) Asian Chemical Biology Initiative 2011/04/01-2016/03/31
独立行政法人科学技術振興機構 戦略的創造研究推進事業CREST 上杉 志成 ケミカルバイオロジーによる脂質内因性分子の新機能研究(H26年度分) Chemical biological exploration of new functions of endogenous lipid-related molecules 2014/10/01-2015/03/31
国立研究開発法人日本医療研究開発機構(AMED) 革新的先端研究開発支援事業 ユニットタイプ「疾患における代謝産物の解析および代謝制御に基づく革新的医療基盤技術の創出」 上杉 志成 ケミカルバイオロジーによる脂質内因性分子の新機能研究(H27-31年度分) Chemical biological exploration of new functions of endogenous lipid-related molecules 2015/04/01-2020/03/31
文部科学省 上杉 志成 転写機能をターゲットとした創薬「転写を標的とした革新的抗がん化合物シーズ」(H26年度分) 2014/12/21-2015/03/31
国立研究開発法人日本医療研究開発機構(AMED) 次世代がん研究シーズ戦略的育成プログラム 革新的がん医療シーズ育成領域 上杉 志成 転写機能をターゲットとした創薬「転写を標的とした革新的抗がん化合物シーズ」 (H27年度分) 2015/04/01-2016/03/31
独立行政法人 科学技術振興機構 シーズ発掘試験研究 上杉 志成 アドヘサミンの応用開拓研究 2008/08/12-2009/03/31
アジア研究教育拠点事業 上杉 志成 アジア発ケミカルバイオロジー (平成27年度分) 2015/04/01-2016/03/31
研究拠点形成事業 B.アジア・アフリカ学術基盤形成型 上杉 志成 ケミカルバイオロジー戦略的アジア拠点 (平成28年度分) 2016/04/01-2017/03/31
研究拠点形成事業 B.アジア・アフリカ学術基盤形成型 上杉 志成 ケミカルバイオロジー戦略的アジア拠点 (平成29年度分) 2017/04/01-2018/03/31
研究拠点形成事業 B.アジア・アフリカ学術基盤形成型 上杉 志成 ケミカルバイオロジー戦略的アジア拠点 (平成30年度分) 2018/04/01-2019/03/31
研究拠点形成事業 B.アジア・アフリカ学術基盤形成型 上杉 志成 協調型アジアケミカルバイオロジー拠点 (2019年度分) 2019/04/01-2020/03/31

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Teaching subject(s)
Name(Japanese) Name(English) Term Department Period
生命の有機化学 The Organic Chemistry of Life 前期 全学共通科目 2011/04-2012/03
生命の有機化学 The Organic Chemistry of Life 前期 全学共通科目 2012/04-2013/03
細胞と物質をつなぐ科学 Integrated Cell-Material Sciences 後期 全学共通科目 2012/04-2013/03
生命の有機化学 The Organic Chemistry of Life 前期 全学共通科目 2013/04-2014/03
生命の有機化学 The Organic Chemistry of Life 前期 全学共通科目 2014/04-2015/03
先端生命科学 Frontier in Life Sciences 通年集中 生命科学研究科 2015/04-2016/03
生命の有機化学 The Organic Chemistry of Life 前期 全学共通科目 2015/04-2016/03
生命の有機化学 Organic Chemistry of Life 前期 全学共通科目 2016/04-2017/03
生命の有機化学 Organic Chemistry of Life 前期 全学共通科目 2017/04-2018/03
生命の有機化学 Organic Chemistry of Life 前期 全学共通科目 2018/04-2019/03
生命の有機化学 Organic Chemistry of Life 前期 全学共通科目 2019/04-2020/03
生命の有機化学 Organic Chemistry of Life 前期集中 全学共通科目 2020/04-2021/03

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Faculty management (title, position)
Title Period
ケミカルスクリーニングセンター長 2011/11/25-2015/11/24
物質-細胞統合システム拠点副拠点長 2013/01/01-2017/03/31
化学研究所運営委員会 委員 2017/04/01-2018/03/31
化学研究所広報委員会 委員 2017/04/01-2018/03/31
化学研究所将来問題・研究活性化委員会 委員 2017/04/01-2018/03/31
物質-細胞統合システム拠点連携主任研究者・副拠点長 2017/04/01-2018/03/31
化学研究所ゲノムネット推進室運営委員会 委員 2018/04/01-2020/03/31
化学研究所広報委員会 委員長 2018/04/01-2019/03/31
化学研究所将来問題・研究活性化委員会 委員 2018/04/01-2019/03/31
物質-細胞統合システム拠点連携主任研究者・副拠点長 2018/04/01-2019/03/31
化学研究所広報委員会 委員長 2019/04/01-2020/03/31
化学研究所将来問題・研究活性化委員会 委員 2019/04/01-2020/03/31
物質-細胞統合システム拠点連携主任研究者・副拠点長 2019/04/01-2020/03/31
化学研究所広報委員会委員長 2020/04/01-2021/03/31
化学研究所財務委員会委員 2020/04/01-2021/03/31
化学研究所情報セキュリティ委員会委員 2020/04/01-2021/03/31

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Other activities (private companies, NPOs, etc.)
Company name Activity Period
大鵬薬品工業株式会社 技術アドバイザー 2001-
公益財団法人アステラス病態代謝研究会 学術委員、選考委員 2012/06/24-2020/06/30
内藤記念科学振興財団 選考委員会委員 2013/04/01-
FGH Biotech, Inc. (USA) Co-Founder 2014/01/-
日本におけるケミカルバイオロジーの新展開第189委員会 委員 2015/04/01-2020/03/31
公益財団法人上原記念生命科学財団 選考委員会委員 2016/04/09-2020/03/31
国立研究開発法人日本医療研究開発機構 AMED課題評価委員 画期的医薬品等の創出をめざす脂質の生理活性と機能の解明 2017/04/01-2019/03/31
文部科学省 科学技術・学術審議会専門委員 2017/04/24-2021/02/14
国立研究開発法人科学技術振興機構 領域アドバイザー 疾患における代謝産物の解析および代謝制御に基づく革新的医療基盤技術の創出 2017/06/25-2019/03/31
Fudan University, School of Pharmacy Distinguished Professor of Shanghai Thousand Talent Program 2017/07/01-2020/06/30
国立研究開発法人科学技術振興機構 パネルメンバー 2019/04/01-2020/03/31
国立研究開発法人科学技術振興機構 領域アドバイザー 2019/06/01-2021/03/31

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Other activities (other)
Activity Misc Period
edX講義「The Chemistry of Life」の提供 ハーバード大学とMITが運営するインターネット教育機関edXに、日本初の講義「The Chemistry of Life(生命の化学)」を英語で世界配信。 2014/04/-