上杉 志成

Last Update: 2019/10/03 09:12:15

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Name(Kanji/Kana/Abecedarium Latinum)
上杉 志成/ウエスギ モトナリ/Uesugi, Motonari
Primary Affiliation(Org1/Job title)
Institute for Chemical Research (ICR)/Professor
Affiliated programs (koza)
Org1 Job title
Graduate Schools Medicine Professor
Graduate Schools Medicine Professor
Concurrent Affiliation
Org1 Job title
物質-細胞統合システム拠点 連携PI
Graduate Schools Medicine
Contact Address
Type Address(Japanese) Address(English)
Office 〒611-0011 京都府宇治市五ヶ庄 Gokasho, Uji, Kyoto 6110011, Japan
Phone
Type Number
Office 0774-38-3225
Academic Degree
Field(Japanese) Field(English) University(Japanese) University(English) Method
修士(薬学) M.S. 京都大学 Kyoto University
博士(薬学) Ph.D 京都大学 Kyoto University
Personal Website(s) (URL(s))
URL
https://www.scl.kyoto-u.ac.jp/~uesugi/ja/index.php
ORCID ID
https://orcid.org/0000-0002-8515-445X
researchmap URL
https://researchmap.jp/read0122106
Research Topics
(Japanese)
ケミカルバイオロジー
(English)
Chemical Biology
Overview of the research
(Japanese)
ケミカルバイオロジーとは、化学を起点とした生物学です。生命の営みはせんじつめれば化学反応でできています。逆に化学を使って生命現象を理解したり、操ることができるはず。私たちの研究室では、生き物やヒト細胞にユニークな効果を及ぼす独自な有機化合物を見つける、もしくはデザインし、それらを道具として生命現象を探究・操作してきました。生物の仕組みは複雑ですが、有機化合物を起爆剤として用いることで、新たな切り口で生物を研究したり操作することができます。私たちの大きな研究目標は、生理活性合成化合物の新しい世界を切り開くことです。生理活性化合物の新しい利用法、新しいカタチをした生理活性化合物、新しいサイズの生理活性化合物など、アイデアを与えることができればと思うのです。こういったアイデアは、未来の創薬の考え方や化合物の細胞治療への利用などに結びつくはずです。
(English)
Chemical biology is an interdisciplinary field of study that is often defined as "chemistry-initiated biology." As biological processes all stem from chemical events, it should be possible to understand or manipulate biological events by using chemistry. Our laboratory has been discovering or designing unique organic molecules that modulate fundamental processes in human cells. Such synthetic organic molecules often serve as tools for basic cell biology. Discovery or design of small molecules with unique biological activity permits small-molecule initiated exploration of complex cellular events. Our mission is to create new world of bioactive synthetic molecules: their new way to use, their new shapes, and their new sizes. We hope to open new avenues for small-molecule applications in a range of fields, including future concepts in drug discovery and use of small molecules for cell therapy.
Fields of research (key words)
Key words(Japanese) Key words(English)
ケミカルバイオロジー Chemical Biology
生理活性小分子 Bioactive Small Molecules
化学プローブ Chemical Probes
細胞治療 Cell Therapy
自己集合 Self-Assembly
化合物ライブラリー Compound Library
Published Papers
Author Author(Japanese) Author(English) Title Title(Japanese) Title(English) Bibliography Bibliography(Japanese) Bibliography(English) Publication date Refereed paper Language Publishing type Disclose
Takashima I, Kusamori K, Hakariya H, Takashima M, Vu TH, Mizukami Y, Noda N, Takayama Y, Katsuda Y, Sato SI, Takakura Y, Nishikawa M, Uesugi M Takashima I, Kusamori K, Hakariya H, Takashima M, Vu TH, Mizukami Y, Noda N, Takayama Y, Katsuda Y, Sato SI, Takakura Y, Nishikawa M, Uesugi M Takashima I, Kusamori K, Hakariya H, Takashima M, Vu TH, Mizukami Y, Noda N, Takayama Y, Katsuda Y, Sato SI, Takakura Y, Nishikawa M, Uesugi M Multifunctionalization of Cells with a Self-Assembling Molecule to Enhance Cell Engraftment. Multifunctionalization of Cells with a Self-Assembling Molecule to Enhance Cell Engraftment. Multifunctionalization of Cells with a Self-Assembling Molecule to Enhance Cell Engraftment. ACS chemical biology, 14, 4, 775-783 ACS chemical biology, 14, 4, 775-783 ACS chemical biology, 14, 4, 775-783 2019/04 Refereed Disclose to all
Yatsuzuka K, Sato SI, Pe KB, Katsuda Y, Takashima I, Watanabe M, Uesugi M Yatsuzuka K, Sato SI, Pe KB, Katsuda Y, Takashima I, Watanabe M, Uesugi M Yatsuzuka K, Sato SI, Pe KB, Katsuda Y, Takashima I, Watanabe M, Uesugi M Live-cell imaging of multiple endogenous mRNAs permits the direct observation of RNA granule dynamics. Live-cell imaging of multiple endogenous mRNAs permits the direct observation of RNA granule dynamics. Live-cell imaging of multiple endogenous mRNAs permits the direct observation of RNA granule dynamics. Chemical communications (Cambridge, England), 54, 52, 7151-7154 Chemical communications (Cambridge, England), 54, 52, 7151-7154 Chemical communications (Cambridge, England), 54, 52, 7151-7154 2018/06 Refereed Disclose to all
Perron A, Nishikawa Y, Iwata J, Shimojo H, Takaya J, Kobayashi K, Imayoshi I, Mbenza NM, Takenoya M, Kageyama R, Kodama Y, Uesugi M Perron A, Nishikawa Y, Iwata J, Shimojo H, Takaya J, Kobayashi K, Imayoshi I, Mbenza NM, Takenoya M, Kageyama R, Kodama Y, Uesugi M Perron A, Nishikawa Y, Iwata J, Shimojo H, Takaya J, Kobayashi K, Imayoshi I, Mbenza NM, Takenoya M, Kageyama R, Kodama Y, Uesugi M Small-molecule screening yields a compound that inhibits the cancer-associated transcription factor Hes1 via the PHB2 chaperone. Small-molecule screening yields a compound that inhibits the cancer-associated transcription factor Hes1 via the PHB2 chaperone. Small-molecule screening yields a compound that inhibits the cancer-associated transcription factor Hes1 via the PHB2 chaperone. The Journal of biological chemistry, 293, 21, 8285-8294 The Journal of biological chemistry, 293, 21, 8285-8294 The Journal of biological chemistry, 293, 21, 8285-8294 2018/05 Refereed Disclose to all
Mao D, Chung XKW, Andoh-Noda T, Qin Y, Sato SI, Takemoto Y, Akamatsu W, Okano H, Uesugi M Mao D, Chung XKW, Andoh-Noda T, Qin Y, Sato SI, Takemoto Y, Akamatsu W, Okano H, Uesugi M Mao D, Chung XKW, Andoh-Noda T, Qin Y, Sato SI, Takemoto Y, Akamatsu W, Okano H, Uesugi M Chemical decontamination of iPS cell-derived neural cell mixtures. Chemical decontamination of iPS cell-derived neural cell mixtures. Chemical decontamination of iPS cell-derived neural cell mixtures. Chemical communications (Cambridge, England), 54, 11, 1355-1358 Chemical communications (Cambridge, England), 54, 11, 1355-1358 Chemical communications (Cambridge, England), 54, 11, 1355-1358 2018/02 Refereed Disclose to all
Sato SI, Yatsuzuka K, Katsuda Y, Uesugi M Sato SI, Yatsuzuka K, Katsuda Y, Uesugi M Sato SI, Yatsuzuka K, Katsuda Y, Uesugi M Method for Imaging Live-Cell RNA Using an RNA Aptamer and a Fluorescent Probe. Method for Imaging Live-Cell RNA Using an RNA Aptamer and a Fluorescent Probe. Method for Imaging Live-Cell RNA Using an RNA Aptamer and a Fluorescent Probe. Methods in molecular biology (Clifton, N.J.), 1649, 305-318 Methods in molecular biology (Clifton, N.J.), 1649, 305-318 Methods in molecular biology (Clifton, N.J.), 1649, 305-318 2018 Refereed Disclose to all
Asano L, Watanabe M, Ryoden Y, Usuda K, Yamaguchi T, Khambu B, Takashima M, Sato SI, Sakai J, Nagasawa K, Uesugi M Asano L, Watanabe M, Ryoden Y, Usuda K, Yamaguchi T, Khambu B, Takashima M, Sato SI, Sakai J, Nagasawa K, Uesugi M Asano L, Watanabe M, Ryoden Y, Usuda K, Yamaguchi T, Khambu B, Takashima M, Sato SI, Sakai J, Nagasawa K, Uesugi M Vitamin D Metabolite, 25-Hydroxyvitamin D, Regulates Lipid Metabolism by Inducing Degradation of SREBP/SCAP. Vitamin D Metabolite, 25-Hydroxyvitamin D, Regulates Lipid Metabolism by Inducing Degradation of SREBP/SCAP. Vitamin D Metabolite, 25-Hydroxyvitamin D, Regulates Lipid Metabolism by Inducing Degradation of SREBP/SCAP. Cell chemical biology, 24, 2, 207-217 Cell chemical biology, 24, 2, 207-217 Cell chemical biology, 24, 2, 207-217 2017/02 Refereed Disclose to all
Mao D, Ando S, Sato SI, Qin Y, Hirata N, Katsuda Y, Kawase E, Kuo TF, Minami I, Shiba Y, Ueda K, Nakatsuji N, Uesugi M Mao D, Ando S, Sato SI, Qin Y, Hirata N, Katsuda Y, Kawase E, Kuo TF, Minami I, Shiba Y, Ueda K, Nakatsuji N, Uesugi M Mao D, Ando S, Sato SI, Qin Y, Hirata N, Katsuda Y, Kawase E, Kuo TF, Minami I, Shiba Y, Ueda K, Nakatsuji N, Uesugi M A Synthetic Hybrid Molecule for the Selective Removal of Human Pluripotent Stem Cells from Cell Mixtures. A Synthetic Hybrid Molecule for the Selective Removal of Human Pluripotent Stem Cells from Cell Mixtures. A Synthetic Hybrid Molecule for the Selective Removal of Human Pluripotent Stem Cells from Cell Mixtures. Angewandte Chemie (International ed. in English), 56, 7, 1765-1770 Angewandte Chemie (International ed. in English), 56, 7, 1765-1770 Angewandte Chemie (International ed. in English), 56, 7, 1765-1770 2017/02 Refereed Disclose to all
Katsuda Y, Sato SI, Asano L, Morimura Y, Furuta T, Sugiyama H, Hagihara M, Uesugi M Katsuda Y, Sato SI, Asano L, Morimura Y, Furuta T, Sugiyama H, Hagihara M, Uesugi M Katsuda Y, Sato SI, Asano L, Morimura Y, Furuta T, Sugiyama H, Hagihara M, Uesugi M A Small Molecule That Represses Translation of G-Quadruplex-Containing mRNA. A Small Molecule That Represses Translation of G-Quadruplex-Containing mRNA. A Small Molecule That Represses Translation of G-Quadruplex-Containing mRNA. Journal of the American Chemical Society, 138, 29, 9037-9040 Journal of the American Chemical Society, 138, 29, 9037-9040 Journal of the American Chemical Society, 138, 29, 9037-9040 2016/07 Refereed English Disclose to all
Takaya J, Mio K, Shiraishi T, Kurokawa T, Otsuka S, Mori Y, Uesugi M Takaya J, Mio K, Shiraishi T, Kurokawa T, Otsuka S, Mori Y, Uesugi M Takaya J, Mio K, Shiraishi T, Kurokawa T, Otsuka S, Mori Y, Uesugi M A Potent and Site-Selective Agonist of TRPA1. A Potent and Site-Selective Agonist of TRPA1. A Potent and Site-Selective Agonist of TRPA1. Journal of the American Chemical Society, 137, 50, 15859-15864 Journal of the American Chemical Society, 137, 50, 15859-15864 Journal of the American Chemical Society, 137, 50, 15859-15864 2015/12 Refereed English Disclose to all
Sato S, Watanabe M, Katsuda Y, Murata A, Wang DO, Uesugi M Sato S, Watanabe M, Katsuda Y, Murata A, Wang DO, Uesugi M Sato S, Watanabe M, Katsuda Y, Murata A, Wang DO, Uesugi M Live-cell imaging of endogenous mRNAs with a small molecule. Live-cell imaging of endogenous mRNAs with a small molecule. Live-cell imaging of endogenous mRNAs with a small molecule. Angewandte Chemie (International ed. in English), 54, 6, 1855-1858 Angewandte Chemie (International ed. in English), 54, 6, 1855-1858 Angewandte Chemie (International ed. in English), 54, 6, 1855-1858 2015/02 Refereed English Disclose to all
Frisco-Cabanos HL, Watanabe M, Okumura N, Kusamori K, Takemoto N, Takaya J, Sato S, Yamazoe S, Takakura Y, Kinoshita S, Nishikawa M, Koizumi N, Uesugi M Frisco-Cabanos HL, Watanabe M, Okumura N, Kusamori K, Takemoto N, Takaya J, Sato S, Yamazoe S, Takakura Y, Kinoshita S, Nishikawa M, Koizumi N, Uesugi M Frisco-Cabanos HL, Watanabe M, Okumura N, Kusamori K, Takemoto N, Takaya J, Sato S, Yamazoe S, Takakura Y, Kinoshita S, Nishikawa M, Koizumi N, Uesugi M Synthetic molecules that protect cells from anoikis and their use in cell transplantation. Synthetic molecules that protect cells from anoikis and their use in cell transplantation. Synthetic molecules that protect cells from anoikis and their use in cell transplantation. Angewandte Chemie (International ed. in English), 53, 42, 11208-11213 Angewandte Chemie (International ed. in English), 53, 42, 11208-11213 Angewandte Chemie (International ed. in English), 53, 42, 11208-11213 2014/10 Refereed English Disclose to all
Kuo TF, Mao D, Hirata N, Khambu B, Kimura Y, Kawase E, Shimogawa H, Ojika M, Nakatsuji N, Ueda K, Uesugi M Kuo TF, Mao D, Hirata N, Khambu B, Kimura Y, Kawase E, Shimogawa H, Ojika M, Nakatsuji N, Ueda K, Uesugi M Kuo TF, Mao D, Hirata N, Khambu B, Kimura Y, Kawase E, Shimogawa H, Ojika M, Nakatsuji N, Ueda K, Uesugi M Selective elimination of human pluripotent stem cells by a marine natural product derivative. Selective elimination of human pluripotent stem cells by a marine natural product derivative. Selective elimination of human pluripotent stem cells by a marine natural product derivative. Journal of the American Chemical Society, 136, 28, 9798-9801 Journal of the American Chemical Society, 136, 28, 9798-9801 Journal of the American Chemical Society, 136, 28, 9798-9801 2014/07 Refereed English Disclose to all
Hirata N, Nakagawa M, Fujibayashi Y, Yamauchi K, Murata A, Minami I, Tomioka M, Kondo T, Kuo TF, Endo H, Inoue H, Sato S, Ando S, Kawazoe Y, Aiba K, Nagata K, Kawase E, Chang YT, Suemori H, Eto K, Nakauchi H, Yamanaka S, Nakatsuji N, Ueda K, Uesugi M Hirata N, Nakagawa M, Fujibayashi Y, Yamauchi K, Murata A, Minami I, Tomioka M, Kondo T, Kuo TF, Endo H, Inoue H, Sato S, Ando S, Kawazoe Y, Aiba K, Nagata K, Kawase E, Chang YT, Suemori H, Eto K, Nakauchi H, Yamanaka S, Nakatsuji N, Ueda K, Uesugi M Hirata N, Nakagawa M, Fujibayashi Y, Yamauchi K, Murata A, Minami I, Tomioka M, Kondo T, Kuo TF, Endo H, Inoue H, Sato S, Ando S, Kawazoe Y, Aiba K, Nagata K, Kawase E, Chang YT, Suemori H, Eto K, Nakauchi H, Yamanaka S, Nakatsuji N, Ueda K, Uesugi M A chemical probe that labels human pluripotent stem cells. A chemical probe that labels human pluripotent stem cells. A chemical probe that labels human pluripotent stem cells. Cell reports, 6, 6, 1165-1174 Cell reports, 6, 6, 1165-1174 Cell reports, 6, 6, 1165-1174 2014/03 Refereed English Disclose to all
Sakano D, Shiraki N, Kikawa K, Yamazoe T, Kataoka M, Umeda K, Araki K, Mao D, Matsumoto S, Nakagata N, Andersson O, Stainier D, Endo F, Kume K, Uesugi M, Kume S Sakano D, Shiraki N, Kikawa K, Yamazoe T, Kataoka M, Umeda K, Araki K, Mao D, Matsumoto S, Nakagata N, Andersson O, Stainier D, Endo F, Kume K, Uesugi M, Kume S Sakano D, Shiraki N, Kikawa K, Yamazoe T, Kataoka M, Umeda K, Araki K, Mao D, Matsumoto S, Nakagata N, Andersson O, Stainier D, Endo F, Kume K, Uesugi M, Kume S VMAT2 identified as a regulator of late-stage β-cell differentiation. VMAT2 identified as a regulator of late-stage β-cell differentiation. VMAT2 identified as a regulator of late-stage β-cell differentiation. Nature chemical biology, 10, 2, 141-148 Nature chemical biology, 10, 2, 141-148 Nature chemical biology, 10, 2, 141-148 2014/02 Refereed English Disclose to all
Takemoto, N.; Suehara, T.; Frisco, H.; Sato, S.; Sezaki, T.; Kusamori, K.; Kawazoe, Y.; Park, S.M.; Yamazoe, S.; Mizuhata, Y.; Inoue, R.; Miller, G.; Hansen, S.; Jayson, G.; Gardiner, J.; Kanaya, T.; Tokitoh, N.; Ueda, K.; Takakura, Y.; Kioka, N.; Nishikawa, M.; Uesugi, M. Takemoto, N.; Suehara, T.; Frisco, H.; Sato, S.; Sezaki, T.; Kusamori, K.; Kawazoe, Y.; Park, S.M.; Yamazoe, S.; Mizuhata, Y.; Inoue, R.; Miller, G.; Hansen, S.; Jayson, G.; Gardiner, J.; Kanaya, T.; Tokitoh, N.; Ueda, K.; Takakura, Y.; Kioka, N.; Nishikawa, M.; Uesugi, M. Takemoto, N.; Suehara, T.; Frisco, H.; Sato, S.; Sezaki, T.; Kusamori, K.; Kawazoe, Y.; Park, S.M.; Yamazoe, S.; Mizuhata, Y.; Inoue, R.; Miller, G.; Hansen, S.; Jayson, G.; Gardiner, J.; Kanaya, T.; Tokitoh, N.; Ueda, K.; Takakura, Y.; Kioka, N.; Nishikawa, M.; Uesugi, M. Small Molecule-induced Clustering of Heparan Sulfate Promotes Cell Adhesion. Small Molecule-induced Clustering of Heparan Sulfate Promotes Cell Adhesion. Small Molecule-induced Clustering of Heparan Sulfate Promotes Cell Adhesion. J. Am. Chem. Soc., 135, 30, 11032-11039 J. Am. Chem. Soc., 135, 30, 11032-11039 J. Am. Chem. Soc., 135, 30, 11032-11039 2013/07 Refereed English Research paper(scientific journal) Disclose to all
D. Jung; L. Abu-Elheiga; R. Ayuzawa; Z. Gu; T. Shirakawa; Y. Fujiki; N. Nakatsuji; S.J. Wakil; M. Uesugi Jung D, Abu-Elheiga L, Ayuzawa R, Gu Z, Shirakawa T, Fujiki Y, Nakatsuji N, Wakil SJ, Uesugi M D. Jung; L. Abu-Elheiga; R. Ayuzawa; Z. Gu; T. Shirakawa; Y. Fujiki; N. Nakatsuji; S.J. Wakil; M. Uesugi Mislocalization and inhibition of acetyl-CoA carboxylase 1 by a synthetic small molecule Mislocalization and inhibition of acetyl-CoA carboxylase 1 by a synthetic small molecule. Mislocalization and inhibition of acetyl-CoA carboxylase 1 by a synthetic small molecule Biochemical Journal, 448, 3, 409-416 The Biochemical journal, 448, 3, 409-416 Biochemical Journal, 448, 3, 409-416 2012/12 Refereed English Disclose to all
I. Minami; K. Yamada; T.G. Otsuji; T. Yamamoto; Y. Shen; S. Otsuka; S. Kadota; N. Morone; M. Barve; Y. Asai; T. Tenkova-Heuser; J.E. Heuser; M. Uesugi; K. Aiba; N. Nakatsuji Minami I, Yamada K, Otsuji TG, Yamamoto T, Shen Y, Otsuka S, Kadota S, Morone N, Barve M, Asai Y, Tenkova-Heuser T, Heuser JE, Uesugi M, Aiba K, Nakatsuji N I. Minami; K. Yamada; T.G. Otsuji; T. Yamamoto; Y. Shen; S. Otsuka; S. Kadota; N. Morone; M. Barve; Y. Asai; T. Tenkova-Heuser; J.E. Heuser; M. Uesugi; K. Aiba; N. Nakatsuji A Small Molecule that Promotes Cardiac Differentiation of Human Pluripotent Stem Cells under Defined, Cytokine- and Xeno-free Conditions A small molecule that promotes cardiac differentiation of human pluripotent stem cells under defined, cytokine- and xeno-free conditions. A Small Molecule that Promotes Cardiac Differentiation of Human Pluripotent Stem Cells under Defined, Cytokine- and Xeno-free Conditions Cell Reports, 2, 5, 1448-1460 Cell reports, 2, 5, 1448-1460 Cell Reports, 2, 5, 1448-1460 2012/11 Refereed English Disclose to all
Khambu, Bilon; Uesugi, Motonari; Kawazoe, Yoshinori Khambu B, Uesugi M, Kawazoe Y Khambu, Bilon; Uesugi, Motonari; Kawazoe, Yoshinori Translational repression stabilizes messenger RNA of autophagy-related genes Translational repression stabilizes messenger RNA of autophagy-related genes. Translational repression stabilizes messenger RNA of autophagy-related genes GENES TO CELLS, 16, 8, 857-867 Genes to cells : devoted to molecular & cellular mechanisms, 16, 8, 857-867 GENES TO CELLS, 16, 8, 857-867 2011/08 Refereed English Disclose to all
S. Kamisuki; T. Shirakawa; A. Kugimiya; L. Abu-Elheiga; H.-Y. Park Choo; K. Yamada; H. Shimogawa; S.J. Wakil; M. Uesugi Kamisuki S, Shirakawa T, Kugimiya A, Abu-Elheiga L, Choo HY, Yamada K, Shimogawa H, Wakil SJ, Uesugi M S. Kamisuki; T. Shirakawa; A. Kugimiya; L. Abu-Elheiga; H.-Y. Park Choo; K. Yamada; H. Shimogawa; S.J. Wakil; M. Uesugi Synthesis and evaluation of diarylthiazole derivatives that inhibit activation of sterol regulatory element-binding proteins Synthesis and evaluation of diarylthiazole derivatives that inhibit activation of sterol regulatory element-binding proteins. Synthesis and evaluation of diarylthiazole derivatives that inhibit activation of sterol regulatory element-binding proteins Journal of Medicinal Chemistry, 54, 13, 4923-4927 Journal of medicinal chemistry, 54, 13, 4923-4927 Journal of Medicinal Chemistry, 54, 13, 4923-4927 2011/07 Refereed English Disclose to all
Y. Kawazoe; H. Shimogawa; A. Sato; M. Uesugi Kawazoe Y, Shimogawa H, Sato A, Uesugi M Y. Kawazoe; H. Shimogawa; A. Sato; M. Uesugi A mitochondrial surface-specific fluorescent probe activated by bioconversion A mitochondrial surface-specific fluorescent probe activated by bioconversion. A mitochondrial surface-specific fluorescent probe activated by bioconversion Angewandte Chemie - International Edition, 50, 24, 5478-5481 Angewandte Chemie (International ed. in English), 50, 24, 5478-5481 Angewandte Chemie - International Edition, 50, 24, 5478-5481 2011/06 Refereed English Disclose to all
E. Sumiya; H. Shimogawa; H. Sasaki; M. Tsutsumi; K. Yoshita; M. Ojika; K. Suenaga; M. Uesugi Sumiya E, Shimogawa H, Sasaki H, Tsutsumi M, Yoshita K, Ojika M, Suenaga K, Uesugi M E. Sumiya; H. Shimogawa; H. Sasaki; M. Tsutsumi; K. Yoshita; M. Ojika; K. Suenaga; M. Uesugi Cell-morphology profiling of a natural product library identifies bisebromoamide and miuraenamide A as actin filament stabilizers Cell-morphology profiling of a natural product library identifies bisebromoamide and miuraenamide A as actin filament stabilizers. Cell-morphology profiling of a natural product library identifies bisebromoamide and miuraenamide A as actin filament stabilizers ACS Chemical Biology, 6, 5, 425-431 ACS chemical biology, 6, 5, 425-431 ACS Chemical Biology, 6, 5, 425-431 2011/05 Refereed English Disclose to all
A. Murata; S.-I. Sato; Y. Kawazoe; M. Uesugi Murata A, Sato S, Kawazoe Y, Uesugi M A. Murata; S.-I. Sato; Y. Kawazoe; M. Uesugi Small-molecule fluorescent probes for specific RNA targets Small-molecule fluorescent probes for specific RNA targets. Small-molecule fluorescent probes for specific RNA targets Chemical Communications, 47, 16, 4712-4714 Chemical communications (Cambridge, England), 47, 16, 4712-4714 Chemical Communications, 47, 16, 4712-4714 2011/04 Refereed English Disclose to all
T. Shirakawa; Y. Kawazoe; T. Tsujikawa; D. Jung; S.-I. Sato; M. Uesugi Shirakawa T, Kawazoe Y, Tsujikawa T, Jung D, Sato S, Uesugi M T. Shirakawa; Y. Kawazoe; T. Tsujikawa; D. Jung; S.-I. Sato; M. Uesugi Deactivation of STAT6 through serine 707 phosphorylation by JNK Deactivation of STAT6 through serine 707 phosphorylation by JNK. Deactivation of STAT6 through serine 707 phosphorylation by JNK Journal of Biological Chemistry, 286, 5, 4003-4010 The Journal of biological chemistry, 286, 5, 4003-4010 Journal of Biological Chemistry, 286, 5, 4003-4010 2011/02 Refereed English Disclose to all
S.-I. Sato; A. Murata; T. Orihara; T. Shirakawa; K. Suenaga; H. Kigoshi; M. Uesugi Sato S, Murata A, Orihara T, Shirakawa T, Suenaga K, Kigoshi H, Uesugi M S.-I. Sato; A. Murata; T. Orihara; T. Shirakawa; K. Suenaga; H. Kigoshi; M. Uesugi Marine natural product aurilide activates the opa1-mediated apoptosis by binding to prohibitin Marine natural product aurilide activates the OPA1-mediated apoptosis by binding to prohibitin. Marine natural product aurilide activates the opa1-mediated apoptosis by binding to prohibitin Chemistry and Biology, 18, 1, 131-139 Chemistry & biology, 18, 1, 131-139 Chemistry and Biology, 18, 1, 131-139 2011/01 Refereed English Disclose to all
R. Murai; Y. Yoshida; T. Muraguchi; E. Nishimoto; Y. Morioka; H. Kitayama; S. Kondoh; Y. Kawazoe; M. Hiraoka; M. Uesugi; M. Noda Murai R, Yoshida Y, Muraguchi T, Nishimoto E, Morioka Y, Kitayama H, Kondoh S, Kawazoe Y, Hiraoka M, Uesugi M, Noda M R. Murai; Y. Yoshida; T. Muraguchi; E. Nishimoto; Y. Morioka; H. Kitayama; S. Kondoh; Y. Kawazoe; M. Hiraoka; M. Uesugi; M. Noda A novel screen using the Reck tumor suppressor gene promoter detects both conventional and metastasis-suppressing anticancer drugs. A novel screen using the Reck tumor suppressor gene promoter detects both conventional and metastasis-suppressing anticancer drugs. A novel screen using the Reck tumor suppressor gene promoter detects both conventional and metastasis-suppressing anticancer drugs. Oncotarget, 1, 4, 252-264 Oncotarget, 1, 4, 252-264 Oncotarget, 1, 4, 252-264 2010/08 Refereed English Disclose to all
S.-i. Sato; A. Murata; T. Shirakawa; M. Uesugi Sato S, Murata A, Shirakawa T, Uesugi M S.-i. Sato; A. Murata; T. Shirakawa; M. Uesugi Biochemical Target Isolation for Novices: Affinity-Based Strategies Biochemical target isolation for novices: affinity-based strategies. Biochemical Target Isolation for Novices: Affinity-Based Strategies Chemistry and Biology, 17, 6, 616-623 Chemistry & biology, 17, 6, 616-623 Chemistry and Biology, 17, 6, 616-623 2010/06 Refereed English Disclose to all
S. Kamisuki; Q. Mao; L. Abu-Elheiga; Z. Gu; A. Kugimiya; Y. Kwon; T. Shinohara; Y. Kawazoe; S.-i. Sato; K. Asakura; H.-Y.P. Choo; J. Sakai; S.J. Wakil; M. Uesugi Kamisuki S, Mao Q, Abu-Elheiga L, Gu Z, Kugimiya A, Kwon Y, Shinohara T, Kawazoe Y, Sato S, Asakura K, Choo HY, Sakai J, Wakil SJ, Uesugi M S. Kamisuki; Q. Mao; L. Abu-Elheiga; Z. Gu; A. Kugimiya; Y. Kwon; T. Shinohara; Y. Kawazoe; S.-i. Sato; K. Asakura; H.-Y.P. Choo; J. Sakai; S.J. Wakil; M. Uesugi A Small Molecule That Blocks Fat Synthesis By Inhibiting the Activation of SREBP A small molecule that blocks fat synthesis by inhibiting the activation of SREBP. A Small Molecule That Blocks Fat Synthesis By Inhibiting the Activation of SREBP Chemistry and Biology, 16, 8, 882-892 Chemistry & biology, 16, 8, 882-892 Chemistry and Biology, 16, 8, 882-892 2009/08 Refereed English Disclose to all
S. Yamazoe; H. Shimogawa; S.-i. Sato; J.D. Esko; M. Uesugi Yamazoe S, Shimogawa H, Sato S, Esko JD, Uesugi M S. Yamazoe; H. Shimogawa; S.-i. Sato; J.D. Esko; M. Uesugi A Dumbbell-Shaped Small Molecule that Promotes Cell Adhesion and Growth A dumbbell-shaped small molecule that promotes cell adhesion and growth. A Dumbbell-Shaped Small Molecule that Promotes Cell Adhesion and Growth Chemistry and Biology, 16, 7, 773-782 Chemistry & biology, 16, 7, 773-782 Chemistry and Biology, 16, 7, 773-782 2009/07 Refereed English Disclose to all
D. Jung; H. Shimogawa; Y. Kwon; Q. Mao; S.-I. Sato; S. Kamisuki; H. Kigoshi; M. Uesugi Jung D, Shimogawa H, Kwon Y, Mao Q, Sato S, Kamisuki S, Kigoshi H, Uesugi M D. Jung; H. Shimogawa; Y. Kwon; Q. Mao; S.-I. Sato; S. Kamisuki; H. Kigoshi; M. Uesugi Wrenchnolol derivative optimized for gene activation in cells Wrenchnolol derivative optimized for gene activation in cells. Wrenchnolol derivative optimized for gene activation in cells Journal of the American Chemical Society, 131, 13, 4774-4782 Journal of the American Chemical Society, 131, 13, 4774-4782 Journal of the American Chemical Society, 131, 13, 4774-4782 2009/04 Refereed English Disclose to all
S.-I. Sato; Y. Kwon; S. Kamisuki; N. Srivastava; Q. Mao; Y. Kawazoe; M. Uesugi Sato S, Kwon Y, Kamisuki S, Srivastava N, Mao Q, Kawazoe Y, Uesugi M S.-I. Sato; Y. Kwon; S. Kamisuki; N. Srivastava; Q. Mao; Y. Kawazoe; M. Uesugi Polyproline-rod approach to isolating protein targets of bioactive small molecules: Isolation of a new target of indomethacin Polyproline-rod approach to isolating protein targets of bioactive small molecules: isolation of a new target of indomethacin. Polyproline-rod approach to isolating protein targets of bioactive small molecules: Isolation of a new target of indomethacin Journal of the American Chemical Society, 129, 4, 873-880 Journal of the American Chemical Society, 129, 4, 873-880 Journal of the American Chemical Society, 129, 4, 873-880 2007/01/31 Refereed English Disclose to all
Jung, DJ; Choi, YM; Uesugi, M Jung D, Choi Y, Uesugi M Jung, DJ; Choi, YM; Uesugi, M Small organic molecules that modulate gene transcription Small organic molecules that modulate gene transcription. Small organic molecules that modulate gene transcription DRUG DISCOVERY TODAY, 11, 9-10, 452-457 Drug discovery today, 11, 9-10, 452-457 DRUG DISCOVERY TODAY, 11, 9-10, 452-457 2006/05 Refereed English Disclose to all
Y. Choi; H. Shimogawa; K. Murakami; L. Ramdas; W. Zhang; J. Qin; M. Uesugi Choi Y, Shimogawa H, Murakami K, Ramdas L, Zhang W, Qin J, Uesugi M Y. Choi; H. Shimogawa; K. Murakami; L. Ramdas; W. Zhang; J. Qin; M. Uesugi Chemical Genetic Identification of the IGF-Linked Pathway that Is Mediated by STAT6 and MFP2 Chemical genetic identification of the IGF-linked pathway that is mediated by STAT6 and MFP2. Chemical Genetic Identification of the IGF-Linked Pathway that Is Mediated by STAT6 and MFP2 Chemistry and Biology, 13, 3, 241-249 Chemistry & biology, 13, 3, 241-249 Chemistry and Biology, 13, 3, 241-249 2006/03 Refereed English Disclose to all
Kwonj, Y; Arndt, HD; Qian, M; Choi, Y; Kawazoe, Y; Dervan, PB; Uesugi, M Kwon Y, Arndt HD, Mao Q, Choi Y, Kawazoe Y, Dervan PB, Uesugi M Kwonj, Y; Arndt, HD; Qian, M; Choi, Y; Kawazoe, Y; Dervan, PB; Uesugi, M Small molecule transcription factor mimic Small molecule transcription factor mimic. Small molecule transcription factor mimic JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 126, 49, 15940-15941 Journal of the American Chemical Society, 126, 49, 15940-15941 JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 126, 49, 15940-15941 2004/12 Refereed English Disclose to all
Uesugi, M Uesugi M Uesugi, M Synthetic molecules that modulate transcription and differentiation: Hints for future drug discovery Synthetic molecules that modulate transcription and differentiation: hints for future drug discovery. Synthetic molecules that modulate transcription and differentiation: Hints for future drug discovery COMBINATORIAL CHEMISTRY & HIGH THROUGHPUT SCREENING, 7, 7, 653-659 Combinatorial chemistry & high throughput screening, 7, 7, 653-659 COMBINATORIAL CHEMISTRY & HIGH THROUGHPUT SCREENING, 7, 7, 653-659 2004/11 Refereed English Disclose to all
Kawazoe, Y., Tanaka, H., Uesugi, M. Kawazoe Y, Tanaka S, Uesugi M Kawazoe, Y., Tanaka, H., Uesugi, M. Chemical genetic identification of histamine receptor H1 as a stimulator of insulin-induced adipogenesis Chemical genetic identification of the histamine H1 receptor as a stimulator of insulin-induced adipogenesis. Chemical genetic identification of histamine receptor H1 as a stimulator of insulin-induced adipogenesis Chem. Biol. 11, 907-913, 11, 7, 907-913 Chemistry & biology, 11, 7, 907-913 Chem. Biol. 11, 907-913, 11, 7, 907-913 2004/07 Refereed English Disclose to all
H. Shimogawa; Y. Kwon; Q. Mao; Y. Kawazoe; Y. Choi; S. Asada; H. Kigoshi; M. Uesugi Shimogawa H, Kwon Y, Mao Q, Kawazoe Y, Choi Y, Asada S, Kigoshi H, Uesugi M H. Shimogawa; Y. Kwon; Q. Mao; Y. Kawazoe; Y. Choi; S. Asada; H. Kigoshi; M. Uesugi A Wrench-Shaped Synthetic Molecule that Modulates a Transcription Factor-Coactivator Interaction A wrench-shaped synthetic molecule that modulates a transcription factor-coactivator interaction. A Wrench-Shaped Synthetic Molecule that Modulates a Transcription Factor-Coactivator Interaction Journal of the American Chemical Society, 126, 11, 3461-3471 Journal of the American Chemical Society, 126, 11, 3461-3471 Journal of the American Chemical Society, 126, 11, 3461-3471 2004/03 Refereed English Disclose to all
Asada, S; Choi, YM; Uesugi, M Asada S, Choi Y, Uesugi M Asada, S; Choi, YM; Uesugi, M A gene-expression inhibitor that targets an alpha-helix-mediated protein interaction A gene-expression inhibitor that targets an alpha-helix-mediated protein interaction. A gene-expression inhibitor that targets an alpha-helix-mediated protein interaction JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 125, 17, 4992-4993 Journal of the American Chemical Society, 125, 17, 4992-4993 JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 125, 17, 4992-4993 2003/04 Refereed English Disclose to all
Choi, YM; Kawazoe, Y; Murakami, K; Misawa, H; Uesugi, M Choi Y, Kawazoe Y, Murakami K, Misawa H, Uesugi M Choi, YM; Kawazoe, Y; Murakami, K; Misawa, H; Uesugi, M Identification of bioactive molecules by adipogenesis profiling of organic compounds Identification of bioactive molecules by adipogenesis profiling of organic compounds. Identification of bioactive molecules by adipogenesis profiling of organic compounds JOURNAL OF BIOLOGICAL CHEMISTRY, 278, 9, 7320-7324 The Journal of biological chemistry, 278, 9, 7320-7324 JOURNAL OF BIOLOGICAL CHEMISTRY, 278, 9, 7320-7324 2003/02 Refereed English Disclose to all
Jabbur J. R., Tabor, A. D., Cheng, X., Wang, H., Uesugi, M., Lozano, G., Zhang, W. Jabbur JR, Tabor AD, Cheng X, Wang H, Uesugi M, Lozano G, Zhang W Jabbur J. R., Tabor, A. D., Cheng, X., Wang, H., Uesugi, M., Lozano, G., Zhang, W. Phosphorylation at threonine 18 of p53 alters hydrogen bonding attenuating mdm2 binding and TAFII31 recruitment Mdm-2 binding and TAF(II)31 recruitment is regulated by hydrogen bond disruption between the p53 residues Thr18 and Asp21. Phosphorylation at threonine 18 of p53 alters hydrogen bonding attenuating mdm2 binding and TAFII31 recruitment Oncogene 21, 7100-7113, 21, 46, 7100-7113 Oncogene, 21, 46, 7100-7113 Oncogene 21, 7100-7113, 21, 46, 7100-7113 2002/10 Refereed English Disclose to all
Suzuki, Takayoshi; Arai, Midori A.; Nakashima, Mitsue; Uesugi, Motonari Suzuki, Takayoshi; Arai, Midori A.; Nakashima, Mitsue; Uesugi, Motonari Merging Chemistry and Biology in Emerging Countries Merging Chemistry and Biology in Emerging Countries CHEMISTRY & BIOLOGY, 20, 4, 461-465 , 20, 4, 461-465 CHEMISTRY & BIOLOGY, 20, 4, 461-465 2013/04/18 Refereed English Disclose to all
T. Morii; M. Uesugi T. Morii; M. Uesugi Two days of experiments in Vietnam: Asian chemical biology initiative, Hanoi meeting Two days of experiments in Vietnam: Asian chemical biology initiative, Hanoi meeting ACS Chemical Biology, 7, 4, 623-625 , 7, 4, 623-625 ACS Chemical Biology, 7, 4, 623-625 2012/04 Refereed English Disclose to all
Henderson YC, Frederick MJ, Jayakumar A, Choi Y, Wang MT, Kang Y, Evans R, Spring PM, Uesugi M, Clayman GL Henderson YC, Frederick MJ, Jayakumar A, Choi Y, Wang MT, Kang Y, Evans R, Spring PM, Uesugi M, Clayman GL Human LBP-32/MGR is a repressor of the P450scc in human choriocarcinoma cell line JEG-3. Human LBP-32/MGR is a repressor of the P450scc in human choriocarcinoma cell line JEG-3. Placenta 28(2-3), 152-160 Placenta 28(2-3), 152-160 2006 English Disclose to all
Choi, Y., Uesugi, M. Choi, Y., Uesugi, M. Regulation of IGF2 functions by a bioactive small molecule Regulation of IGF2 functions by a bioactive small molecule FASEB Journal, 18, C219-C219 FASEB Journal, 18, C219-C219 2004 English Disclose to all
Skowyra, D., Zeremski, M., Neznanov, N., Li, M., Choi, Y., Uesugi, M., Hauser, C. A., Gu, W., Gudkov, A. V., Qin, J. Skowyra, D., Zeremski, M., Neznanov, N., Li, M., Choi, Y., Uesugi, M., Hauser, C. A., Gu, W., Gudkov, A. V., Qin, J. Differential Association of Products of Alternative Transcripts of the Candidate Tumor Suppressor ING1 with the mSin3/HDAC1 Transcriptional Corepressor Complex Differential Association of Products of Alternative Transcripts of the Candidate Tumor Suppressor ING1 with the mSin3/HDAC1 Transcriptional Corepressor Complex J. Biol. Chem. 276, 8713-8719 J. Biol. Chem. 276, 8713-8719 2001 Refereed English Disclose to all
Choi, Y; Asada, S; Uesugi, M Choi, Y; Asada, S; Uesugi, M Divergent hTAF(II)31-binding motifs hidden in activation domains Divergent hTAF(II)31-binding motifs hidden in activation domains JOURNAL OF BIOLOGICAL CHEMISTRY, 275, 21, 15912-15916 , 275, 21, 15912-15916 JOURNAL OF BIOLOGICAL CHEMISTRY, 275, 21, 15912-15916 2000/05/26 Refereed English Disclose to all
Park S. J., Uesugi, M., Sun, L. J., Crabtree, G. R., Verdine, G. L. Park S. J., Uesugi, M., Sun, L. J., Crabtree, G. R., Verdine, G. L. Existence of a Second Calcineurin Binding Site on Select Isoforms of NFAT Existence of a Second Calcineurin Binding Site on Select Isoforms of NFAT FASEB Journal, 13, A1495-A1495 FASEB Journal, 13, A1495-A1495 1999 English Disclose to all
Uesugi, M; Nyanguile, O; Lu, H; Levine, AJ; Verdine, GL Uesugi, M; Nyanguile, O; Lu, H; Levine, AJ; Verdine, GL Induced alpha helix in the VP16 activation domain upon binding to a human TAF Induced alpha helix in the VP16 activation domain upon binding to a human TAF SCIENCE, 277, 5330, 1310-1313 , 277, 5330, 1310-1313 SCIENCE, 277, 5330, 1310-1313 1997/08/29 Refereed English Disclose to all
KUSAKABE, T; UESUGI, M; SUGIURA, Y KUSAKABE, T; UESUGI, M; SUGIURA, Y SEQUENCE PREFERENCE FOR STRAND CLEAVAGE OF GAPPED DUPLEXES BY DYNEMICIN-A - POSSIBLE MECHANISM OF SEQUENCE-DEPENDENT DOUBLE-STRANDED BREAKS SEQUENCE PREFERENCE FOR STRAND CLEAVAGE OF GAPPED DUPLEXES BY DYNEMICIN-A - POSSIBLE MECHANISM OF SEQUENCE-DEPENDENT DOUBLE-STRANDED BREAKS BIOCHEMISTRY, 34, 31, 9944-9950 , 34, 31, 9944-9950 BIOCHEMISTRY, 34, 31, 9944-9950 1995/08/08 Refereed English Disclose to all
UESUGI, M; KUSAKABE, T; SUGIURA, Y UESUGI, M; KUSAKABE, T; SUGIURA, Y HYDROPHOBIC DNA-BINDING OF ESPERAMICIN REQUIRES CONFORMATIONAL DISTORTION OF THE HOST DNA HYDROPHOBIC DNA-BINDING OF ESPERAMICIN REQUIRES CONFORMATIONAL DISTORTION OF THE HOST DNA BIOCHIMICA ET BIOPHYSICA ACTA-GENE STRUCTURE AND EXPRESSION, 1261, 1, 99-106 , 1261, 1, 99-106 BIOCHIMICA ET BIOPHYSICA ACTA-GENE STRUCTURE AND EXPRESSION, 1261, 1, 99-106 1995/03/14 Refereed English Disclose to all
R. Totsuka; Y. Aizawa; M. Uesugi; Y. Okuno; T. Matsumoto; Y. Sugiura R. Totsuka; Y. Aizawa; M. Uesugi; Y. Okuno; T. Matsumoto; Y. Sugiura RNA cleavage by C-1027 chromophore, an enediyne antitumor antibiotic: High selectivity to an anticodon arm RNA cleavage by C-1027 chromophore, an enediyne antitumor antibiotic: High selectivity to an anticodon arm Biochemical and Biophysical Research Communications, 208, 1, 168-173 , 208, 1, 168-173 Biochemical and Biophysical Research Communications, 208, 1, 168-173 1995/03/08 Refereed English Disclose to all
KUSHIDA, T; UESUGI, M; SUGIURA, Y; KIGOSHI, H; TANAKA, H; HIROKAWA, J; OJIKA, M; YAMADA, K KUSHIDA, T; UESUGI, M; SUGIURA, Y; KIGOSHI, H; TANAKA, H; HIROKAWA, J; OJIKA, M; YAMADA, K DNA-DAMAGE BY PTAQUILOSIDE, A POTENT BRACKEN CARCINOGEN - DETECTION OF SELECTIVE STRAND BREAKS AND IDENTIFICATION OF DNA CLEAVAGE PRODUCTS DNA-DAMAGE BY PTAQUILOSIDE, A POTENT BRACKEN CARCINOGEN - DETECTION OF SELECTIVE STRAND BREAKS AND IDENTIFICATION OF DNA CLEAVAGE PRODUCTS JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 116, 2, 479-486 , 116, 2, 479-486 JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 116, 2, 479-486 1994/01/26 Refereed English Disclose to all
KUSAKABE, T; MAEKAWA, K; ICHIKAWA, A; UESUGI, M; SUGIURA, Y KUSAKABE, T; MAEKAWA, K; ICHIKAWA, A; UESUGI, M; SUGIURA, Y CONFORMATION-SELECTIVE DNA STRAND BREAKS BY DYNEMICIN - A MOLECULAR WEDGE INTO FLEXIBLE REGIONS OF DNA CONFORMATION-SELECTIVE DNA STRAND BREAKS BY DYNEMICIN - A MOLECULAR WEDGE INTO FLEXIBLE REGIONS OF DNA BIOCHEMISTRY, 32, 43, 11669-11675 , 32, 43, 11669-11675 BIOCHEMISTRY, 32, 43, 11669-11675 1993/11/02 Refereed English Disclose to all
UESUGI, M; SUGIURA, Y UESUGI, M; SUGIURA, Y NEW INSIGHTS INTO SEQUENCE RECOGNITION PROCESS OF ESPERAMICIN-A(1) AND CALICHEAMICIN-GAMMA-1(I) - ORIGIN OF THEIR SELECTIVITIES AND INDUCED FIT MECHANISM NEW INSIGHTS INTO SEQUENCE RECOGNITION PROCESS OF ESPERAMICIN-A(1) AND CALICHEAMICIN-GAMMA-1(I) - ORIGIN OF THEIR SELECTIVITIES AND INDUCED FIT MECHANISM BIOCHEMISTRY, 32, 17, 4622-4627 , 32, 17, 4622-4627 BIOCHEMISTRY, 32, 17, 4622-4627 1993/05/04 Refereed English Disclose to all
TOKUDA M;FUJIWARA K;GOMIBUCHI T;HIRAMA M;UESUGI M;SUGIURA Y TOKUDA M;FUJIWARA K;GOMIBUCHI T;HIRAMA M;UESUGI M;SUGIURA Y Synthesis of a Hybrid Molecule Containing Neocarzinostatin Chromophore Analogue and Minor Groove Binder. Synthesis of a Hybrid Molecule Containing Neocarzinostatin Chromophore Analogue and Minor Groove Binder. Tetrahedron Lett, 34, 4, 669-672 , 34, 4, 669-672 Tetrahedron Lett, 34, 4, 669-672 1993/01/22 Refereed English Disclose to all
SHIRAKI, T; UESUGI, M; SUGIURA, Y SHIRAKI, T; UESUGI, M; SUGIURA, Y C-1' HYDROGEN ABSTRACTION OF DEOXYRIBOSE IN DNA STRAND SCISSION BY DYNEMICIN-A C-1' HYDROGEN ABSTRACTION OF DEOXYRIBOSE IN DNA STRAND SCISSION BY DYNEMICIN-A BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 188, 2, 584-589 , 188, 2, 584-589 BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 188, 2, 584-589 1992/10/30 Refereed English Disclose to all
UESUGI, M; SUGIURA, Y UESUGI, M; SUGIURA, Y PRODUCT ANALYSES IN DNA STRAND SCISSION BY ANTITUMOR ANTIBIOTIC ELSAMICIN-A PRODUCT ANALYSES IN DNA STRAND SCISSION BY ANTITUMOR ANTIBIOTIC ELSAMICIN-A BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 186, 1, 580-587 , 186, 1, 580-587 BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 186, 1, 580-587 1992/07/15 Refereed English Disclose to all
OWA, T; HAUPT, A; OTSUKA, M; KOBAYASHI, S; TOMIOKA, N; ITAI, A; OHNO, M; SHIRAKI, T; UESUGI, M; SUGIURA, Y; MAEDA, K OWA, T; HAUPT, A; OTSUKA, M; KOBAYASHI, S; TOMIOKA, N; ITAI, A; OHNO, M; SHIRAKI, T; UESUGI, M; SUGIURA, Y; MAEDA, K MAN-DESIGNED BLEOMYCINS - SIGNIFICANCE OF THE BINDING-SITES AS ENZYME MODELS AND OF THE STEREOCHEMISTRY OF THE LINKER MOIETY MAN-DESIGNED BLEOMYCINS - SIGNIFICANCE OF THE BINDING-SITES AS ENZYME MODELS AND OF THE STEREOCHEMISTRY OF THE LINKER MOIETY TETRAHEDRON, 48, 7, 1193-1208 , 48, 7, 1193-1208 TETRAHEDRON, 48, 7, 1193-1208 1992/02/14 Refereed English Disclose to all
HIRAMA, M; GOMIBUCHI, T; FUJIWARA, K; SUGIURA, Y; UESUGI, M HIRAMA, M; GOMIBUCHI, T; FUJIWARA, K; SUGIURA, Y; UESUGI, M SYNTHESIS AND DNA-CLEAVING ABILITIES OF FUNCTIONAL NEOCARZINOSTATIN CHROMOPHORE ANALOGS - BASE DISCRIMINATION BY A SIMPLE ALCOHOL SYNTHESIS AND DNA-CLEAVING ABILITIES OF FUNCTIONAL NEOCARZINOSTATIN CHROMOPHORE ANALOGS - BASE DISCRIMINATION BY A SIMPLE ALCOHOL JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 113, 26, 9851-9853 , 113, 26, 9851-9853 JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 113, 26, 9851-9853 1991/12/18 Refereed English Disclose to all
UESUGI, M; SEKIDA, T; MATSUKI, S; SUGIURA, Y UESUGI, M; SEKIDA, T; MATSUKI, S; SUGIURA, Y SELECTIVE DNA CLEAVAGE BY ELSAMICIN-A AND SWITCH FUNCTION OF ITS AMINO SUGAR GROUP SELECTIVE DNA CLEAVAGE BY ELSAMICIN-A AND SWITCH FUNCTION OF ITS AMINO SUGAR GROUP BIOCHEMISTRY, 30, 27, 6711-6715 , 30, 27, 6711-6715 BIOCHEMISTRY, 30, 27, 6711-6715 1991/07/09 English Disclose to all
SUGIURA, Y; ARAKAWA, T; UESUGI, M; SHIRAKI, T; OHKUMA, H; KONISHI, M SUGIURA, Y; ARAKAWA, T; UESUGI, M; SHIRAKI, T; OHKUMA, H; KONISHI, M REDUCTIVE AND NUCLEOPHILIC ACTIVATION PRODUCTS OF DYNEMICIN-A WITH METHYL THIOGLYCOLATE - A RATIONAL MECHANISM FOR DNA CLEAVAGE OF THE THIOL-ACTIVATED DYNEMICIN-A REDUCTIVE AND NUCLEOPHILIC ACTIVATION PRODUCTS OF DYNEMICIN-A WITH METHYL THIOGLYCOLATE - A RATIONAL MECHANISM FOR DNA CLEAVAGE OF THE THIOL-ACTIVATED DYNEMICIN-A BIOCHEMISTRY, 30, 12, 2989-2992 , 30, 12, 2989-2992 BIOCHEMISTRY, 30, 12, 2989-2992 1991/03/26 Refereed English Disclose to all
Uesugi, M. Uesugi, M. Small Molecule Tools for Cell Biology and Cell Therapy Small Molecule Tools for Cell Biology and Cell Therapy Chembiomolecular Science at the Frontier of Chemistry and Biology , 51-58 Chembiomolecular Science at the Frontier of Chemistry and Biology , 51-58 Other Disclose to all

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Author Author(Japanese) Author(English) Title Title(Japanese) Title(English) Publisher Publisher(Japanese) Publisher(English) Publication date Language Type Disclose
日本学術振興会ケミカルバイオロジー第189委員会 日本学術振興会ケミカルバイオロジー第189委員会 ケミカルバイオロジー化合物集 研究展開のヒント ケミカルバイオロジー化合物集 研究展開のヒント オーム社 オーム社 2018/10 Other Disclose to all
上杉 志成 上杉 志成 京都大学 アイデアが湧いてくる講義 サイエンスの発想法 京都大学 アイデアが湧いてくる講義 サイエンスの発想法 祥伝社黄金文庫 祥伝社黄金文庫 2017/09 Single Work Disclose to all
上杉志成 上杉志成 京都大学人気講義 サイエンスの発想法 京都大学人気講義 サイエンスの発想法 祥伝社 祥伝社 2014/04/30 Single Work Disclose to all
ケミカルバイオロジー ケミカルバイオロジー 共立出版 共立出版 2008/05 Joint Editor Disclose to all
長野哲雄, 長田裕之, 菊地和也, 上杉志成 長野哲雄, 長田裕之, 菊地和也, 上杉志成 ケミカルバイオロジー PNE 蛋白質 核酸 酵素 2007年10月号増刊 ケミカルバイオロジー PNE 蛋白質 核酸 酵素 2007年10月号増刊 共立出版 共立出版 2007 Joint Work Disclose to all
長野哲雄, 長田裕之, 菊地和也, 上杉志成 長野哲雄, 長田裕之, 菊地和也, 上杉志成 ゲノムサイエンスの新たなる挑戦 PNE 蛋白質 核酸 酵素 2001年12月号増刊 ゲノムサイエンスの新たなる挑戦 PNE 蛋白質 核酸 酵素 2001年12月号増刊 共立出版 共立出版 2001 Joint Work Disclose to all
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Inventor(s) Inventor(s) (Japanese) Inventor(s) (English) Title Title(Japanese) Title(English) Stage Patent number Date Disclose
ジョエル ハフ, 上杉 志成, ジョン キンケイド ジョエル ハフ, 上杉 志成, ジョン キンケイド 疾患の治療のための二置換ピラゾール化合物 疾患の治療のための二置換ピラゾール化合物 特許公開 特表2019-515956 2019/06/13 Disclose to all
渡邉 瑞貴, 浅野 理沙, 長澤 和夫, 上杉 志成 渡邉 瑞貴, 浅野 理沙, 長澤 和夫, 上杉 志成 ビタミンD3誘導体及びその薬学的用途 ビタミンD3誘導体及びその薬学的用途 特許公開 特表2018-502100 2018/01/25 Disclose to all
Title language:
Awards
Title(Japanese) Title(English) Organization name(Japanese) Organization name(English) Date
若手研究奨励賞 Lymphoma Research Foundation アメリカリンパ腫研究財団 Young Investigator Award 2001/07/
若手研究奨励賞 Research Scholar Award アメリカ癌財団 American Cancer Society 2003/07/
ゴールドメダル賞 Gold Medal Award 東京テクノフォーラム21 Tokyo Techno-Forum 2006/04/
学術振興賞  Award for Divisional Scientific Promotions 日本薬学会 The Pharmaceutical Society of Japan 2011/03/
ドイツ イノベーションアワード ゴットフリード・ワグネル賞 2010 (1等) German Innovation Award Gottfried Wagener Prize 2010 (1st Prize)  ドイツ 科学・イノベーション フォーラム東京、在日ドイツ商工会議所 German Research and Innovation Forum Tokyo & German Chamber of Commerce and Industry in Japan 2011/05/
第49回市村学術賞貢献賞 The 49th Ichimura Prize in Science for Distinguished Achievement 公益財団法人新技術開発財団 The New Technology Development Foundation 2017/04/26
External funds: competitive funds and Grants-in-Aid for Scientific Research (Kakenhi)
Type Position Title(Japanese) Title(English) Period
基盤研究(B) Representative 小分子有機化合物を起爆剤とした細胞シグナル解析 2009/04/01-2011/03/31
挑戦的萌芽研究 Representative 転写因子Hes1の振動を制御する小分子化合物 (平成26年度分) 2014/04/01-2015/03/31
新学術領域研究(研究領域提案型) Representative 脂質関連内因性分子の新機能発掘と調節 (平成26年度分) 2014/04/01-2015/03/31
基盤研究(S) Representative 合成小分子化合物による細胞の操作と分析 (平成26年度分) 2014/05/30-2015/03/31
基盤研究(S) Representative 合成小分子化合物による細胞の操作と分析 (平成27年度分) 2015/04/01-2016/03/31
挑戦的萌芽研究 Representative 転写因子Hes1の振動を制御する小分子化合物 (平成27年度分) 2015/04/01-2016/03/31
新学術領域研究(研究領域提案型) Representative 脂質関連内因性分子の新機能発掘と調節 (平成27年度分) 2015/04/01-2016/03/31
基盤研究(S) Representative 合成小分子化合物による細胞の操作と分析 (平成28年度分) 2016/04/01-2017/03/31
特別研究員奨励費 Representative RNAのGグアドルプレックスを認識する化合物の開発と利用 (平成28年度分) 2016/04/01-2017/03/31
挑戦的研究(萌芽) Representative 人工翻訳後修飾 (平成29年度分) 2017/04/01-2018/03/31
基盤研究(S) Representative 合成小分子化合物による細胞の操作と分析 (平成29年度分) 2017/04/01-2018/03/31
新学術領域研究(研究領域提案型) Representative 人工栄養素結合体の化学シグナル (平成29年度分) 2017/04/01-2018/03/31
特別研究員奨励費 Representative RNAのGグアドルプレックスを認識する化合物の開発と利用 (平成29年度分) 2017/04/01-2018/03/31
挑戦的研究(萌芽) Representative 人工翻訳後修飾 (平成30年度分) 2018/04/01-2019/03/31
基盤研究(S) Representative 合成小分子化合物による細胞の操作と分析 (平成30年度分) 2018/04/01-2019/03/31
新学術領域研究(研究領域提案型) Representative 人工栄養素結合体の化学シグナル (平成30年度分) 2018/04/01-2019/03/31

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External funds: other than those above
System Main person Title(Japanese) Title(English) Period
独立行政法人科学技術振興機構 戦略的創造研究推進事業 さきがけ 上杉 志成 生命現象分析のための小分子転写因子創成 2005/10/-2009/03/
独立行政法人科学技術振興機構 研究成果最適展開支援事業(A-STEP)フィージビリティスタディ 上杉 志成 細胞接着促進化合物の実用化 2009/11/01-2010/10/31
独立行政法人日本学術振興会 最先端・次世代研究開発支援プログラム 上杉 志成 合成小分子化合物による細胞の操作と分析(H23-26) Control and Analysis of Cells by Synthetic Small Molecules 2011/02/-2014/03/31
独立行政法人日本学術振興会 アジア研究教育拠点事業 上杉 志成 アジア発ケミカルバイオロジー(H23-27) Asian Chemical Biology Initiative 2011/04/01-2016/03/31
独立行政法人科学技術振興機構 戦略的創造研究推進事業CREST 上杉 志成 ケミカルバイオロジーによる脂質内因性分子の新機能研究(H26年度分) Chemical biological exploration of new functions of endogenous lipid-related molecules 2014/10/01-2015/03/31
国立研究開発法人日本医療研究開発機構(AMED) 革新的先端研究開発支援事業 ユニットタイプ「疾患における代謝産物の解析および代謝制御に基づく革新的医療基盤技術の創出」 上杉 志成 ケミカルバイオロジーによる脂質内因性分子の新機能研究(H27-31年度分) Chemical biological exploration of new functions of endogenous lipid-related molecules 2015/04/01-2020/03/31
文部科学省 上杉 志成 転写機能をターゲットとした創薬「転写を標的とした革新的抗がん化合物シーズ」(H26年度分) 2014/12/21-2015/03/31
国立研究開発法人日本医療研究開発機構(AMED) 次世代がん研究シーズ戦略的育成プログラム 革新的がん医療シーズ育成領域 上杉 志成 転写機能をターゲットとした創薬「転写を標的とした革新的抗がん化合物シーズ」 (H27年度分) 2015/04/01-2016/03/31
独立行政法人 科学技術振興機構 シーズ発掘試験研究 上杉 志成 アドヘサミンの応用開拓研究 2008/08/12-2009/03/31
アジア研究教育拠点事業 上杉 志成 アジア発ケミカルバイオロジー (平成27年度分) 2015/04/01-2016/03/31
研究拠点形成事業 B.アジア・アフリカ学術基盤形成型 上杉 志成 ケミカルバイオロジー戦略的アジア拠点 (平成28年度分) 2016/04/01-2017/03/31
研究拠点形成事業 B.アジア・アフリカ学術基盤形成型 上杉 志成 ケミカルバイオロジー戦略的アジア拠点 (平成29年度分) 2017/04/01-2018/03/31
研究拠点形成事業 B.アジア・アフリカ学術基盤形成型 上杉 志成 ケミカルバイオロジー戦略的アジア拠点 (平成30年度分) 2018/04/01-2019/03/31

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Teaching subject(s)
Name(Japanese) Name(English) Term Department Period
生命の有機化学 The Organic Chemistry of Life 前期 全学共通科目 2011/04-2012/03
生命の有機化学 The Organic Chemistry of Life 前期 全学共通科目 2012/04-2013/03
細胞と物質をつなぐ科学 Integrated Cell-Material Sciences 後期 全学共通科目 2012/04-2013/03
生命の有機化学 The Organic Chemistry of Life 前期 全学共通科目 2013/04-2014/03
生命の有機化学 The Organic Chemistry of Life 前期 全学共通科目 2014/04-2015/03
先端生命科学 Frontier in Life Sciences 通年集中 生命科学研究科 2015/04-2016/03
生命の有機化学 The Organic Chemistry of Life 前期 全学共通科目 2015/04-2016/03
生命の有機化学 Organic Chemistry of Life 前期 全学共通科目 2016/04-2017/03
生命の有機化学 Organic Chemistry of Life 前期 全学共通科目 2017/04-2018/03
生命の有機化学 Organic Chemistry of Life 前期 全学共通科目 2018/04-2019/03
生命の有機化学 Organic Chemistry of Life 前期 全学共通科目 2019/04-2020/03

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Faculty management (title, position)
Title Period
副拠点長 1970/01/01-
ケミカルスクリーニングセンター長 2011/11/25-2015/11/24
化学研究所運営委員会委員 2017/04/01-2018/03/31
化学研究所広報委員会委員 2017/04/01-2018/03/31
化学研究所将来問題・研究活性化委員会委員 2017/04/01-2018/03/31
2018/04/01-2019/03/31
2018/04/01-2019/03/31
2018/04/01-2020/03/31
化学研究所将来問題・研究活性化委員会委員 2018/04/01-2019/03/31
化学研究所広報委員会委員長 2018/04/01-2019/03/31
化学研究所ゲノムネット推進室運営委員会委員 2018/04/01-2020/03/31
化学研究所将来問題・研究活性化委員会委員 2019/04/01-2020/03/31
化学研究所広報委員会委員長 2019/04/01-2020/03/31

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Other activities (private companies, NPOs, etc.)
Company name Activity Period
大鵬薬品工業株式会社 技術アドバイザー 2001-
公益財団法人アステラス病態代謝研究会 学術委員、選考委員 2012/06/24-2020/06/30
内藤記念科学振興財団 選考委員会委員 2013/04/01-
FGH Biotech, Inc. (USA) Co-Founder 2014/01/-
日本におけるケミカルバイオロジーの新展開第189委員会 委員 2015/04/01-2020/03/31
公益財団法人上原記念生命科学財団 選考委員会委員 2016/04/09-2020/03/31
国立研究開発法人日本医療研究開発機構 AMED課題評価委員 画期的医薬品等の創出をめざす脂質の生理活性と機能の解明 2017/04/01-2019/03/31
文部科学省 科学技術・学術審議会専門委員 2017/04/24-2021/02/14
国立研究開発法人科学技術振興機構 領域アドバイザー 疾患における代謝産物の解析および代謝制御に基づく革新的医療基盤技術の創出 2017/06/25-2019/03/31
Fudan University, School of Pharmacy Distinguished Professor of Shanghai Thousand Talent Program 2017/07/01-2020/06/30
国立研究開発法人科学技術振興機構 パネルメンバー 2019/04/01-2020/03/31
国立研究開発法人科学技術振興機構 領域アドバイザー 2019/06/01-2021/03/31

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Other activities (other)
Activity Misc Period
edX講義「The Chemistry of Life」の提供 ハーバード大学とMITが運営するインターネット教育機関edXに、日本初の講義「The Chemistry of Life(生命の化学)」を英語で世界配信。 2014/04/-