前 伸一

Last Update: 2019/06/26 17:03:09

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Name(Kanji/Kana/Abecedarium Latinum)
前 伸一/マエ シンイチ/Mae, Shin-ichi
Primary Affiliation(Org1/Job title)
iPS細胞研究所/Program-Specific Research Center Assistant Professor
Academic Degree
Field(Japanese) Field(English) University(Japanese) University(English) Method
修士(医科学) 信州大学
博士(医学) 京都大学
researchmap URL
https://researchmap.jp/7000015503
Research Topics
(Japanese)
iPS細胞を用いた腎臓再生医療の開発
(English)
Development of kidney regeneration using induced pluripotent stem cells
Overview of the research
(Japanese)
末期慢性腎不全により透析療法を受けている患者総数は毎年増え続けている。腎疾患に対する有効な治療法は未だ確立されておらず、高齢化社会も相まって、今後も透析医療費は増加することが予想される。一方、近年、多能性幹細胞から主要臓器を作製する研究が盛んに行われている。そこで、iPS細胞から腎細胞を分化誘導する方法を開発し、腎発生に関わるシグナル分子や機構の解明、難治遺伝性腎疾患に対する新規病態モデルの開発および治療薬の探索を行っている。
(English)
The total number of patients receiving dialysis therapy due to end-stage chronic renal failure continues to increase every year. Effective treatment for renal diseases has not been established yet, coupled with the aging society, it is expected that dialysis medical expenses will continue to increase. On the other hand, research to induce major organs from pluripotent stem cells has been actively conducted in recent years. Therefore, I am developing a method to induce renal cells from iPS cells, elucidating the signal molecules and mechanisms involved in renal development, and developing a novel pathological model for intractable hereditary renal diseases.
Fields of research (key words)
Key words(Japanese) Key words(English)
再生医学 Regenerative medicine
幹細胞生物学 Stem cell biology
Published Papers
Author Author(Japanese) Author(English) Title Title(Japanese) Title(English) Bibliography Bibliography(Japanese) Bibliography(English) Publication date Refereed paper Language Publishing type Disclose
Matsui S, Ochiai M, Yasuda K, Mae SI, Kotaka M, Toyoda T, Yamamoto T, Osafune K Matsui S, Ochiai M, Yasuda K, Mae SI, Kotaka M, Toyoda T, Yamamoto T, Osafune K Matsui S, Ochiai M, Yasuda K, Mae SI, Kotaka M, Toyoda T, Yamamoto T, Osafune K Differentiation and isolation of iPSC-derived remodeling ductal plate-like cells by use of an AQP1-GFP reporter human iPSC line. Differentiation and isolation of iPSC-derived remodeling ductal plate-like cells by use of an AQP1-GFP reporter human iPSC line. Differentiation and isolation of iPSC-derived remodeling ductal plate-like cells by use of an AQP1-GFP reporter human iPSC line. Stem cell research, 35, 101400 Stem cell research, 35, 101400 Stem cell research, 35, 101400 2019/03 Refereed Disclose to all
Sakamoto S, Mae SI, Osafune K, Okada C, Kabai R, Watanabe A Sakamoto S, Mae SI, Osafune K, Okada C, Kabai R, Watanabe A Sakamoto S, Mae SI, Osafune K, Okada C, Kabai R, Watanabe A [Dissecting early development of the kidney by single cell transcriptomics]. [Dissecting early development of the kidney by single cell transcriptomics]. [Dissecting early development of the kidney by single cell transcriptomics]. Nihon yakurigaku zasshi. Folia pharmacologica Japonica, 153, 2, 61-66 Nihon yakurigaku zasshi. Folia pharmacologica Japonica, 153, 2, 61-66 Nihon yakurigaku zasshi. Folia pharmacologica Japonica, 153, 2, 61-66 2019 Refereed Disclose to all
Mae SI, Ryosaka M, Osafune K Mae SI, Ryosaka M, Osafune K Mae SI, Ryosaka M, Osafune K Protocol to Generate Ureteric Bud Structures from Human iPS Cells. Protocol to Generate Ureteric Bud Structures from Human iPS Cells. Protocol to Generate Ureteric Bud Structures from Human iPS Cells. Methods in molecular biology (Clifton, N.J.), 1926, 117-123 Methods in molecular biology (Clifton, N.J.), 1926, 117-123 Methods in molecular biology (Clifton, N.J.), 1926, 117-123 2019 Refereed Disclose to all
Hoshina A, Kawamoto T, Sueta SI, Mae SI, Araoka T, Tanaka H, Sato Y, Yamagishi Y, Osafune K Hoshina A, Kawamoto T, Sueta SI, Mae SI, Araoka T, Tanaka H, Sato Y, Yamagishi Y, Osafune K Development of new method to enrich human iPSC-derived renal progenitors using cell surface markers. Development of new method to enrich human iPSC-derived renal progenitors using cell surface markers. Development of new method to enrich human iPSC-derived renal progenitors using cell surface markers. Scientific Reports, 8, 6375 Scientific Reports, 8, 6375 Scientific Reports, 8, 6375 2018/04 Refereed English Research paper(scientific journal) Disclose to all
Mae SI, Ryosaka M, Toyoda T, Matsuse K, Oshima Y, Tsujimoto H, Okumura S, Shibasaki A, Osafune K Mae SI, Ryosaka M, Toyoda T, Matsuse K, Oshima Y, Tsujimoto H, Okumura S, Shibasaki A, Osafune K Generation of branching ureteric bud tissues from human pluripotent stem cells. Generation of branching ureteric bud tissues from human pluripotent stem cells. Generation of branching ureteric bud tissues from human pluripotent stem cells. Biochemcal and Biophysical Research Communications, 1;495, 1, 954-961 Biochemcal and Biophysical Research Communications, 1;495, 1, 954-961 Biochemcal and Biophysical Research Communications, 1;495, 1, 954-961 2018/01 Refereed English Research paper(scientific journal) Disclose to all
Hitomi H, Kasahara T, Katagiri N, Hoshina A, Mae SI, Kotaka M, Toyohara T, Rahman A, Nakano D, Niwa A, Saito MK, Nakahata T, Nishiyama A, Osafune K Hitomi H, Kasahara T, Katagiri N, Hoshina A, Mae SI, Kotaka M, Toyohara T, Rahman A, Nakano D, Niwa A, Saito MK, Nakahata T, Nishiyama A, Osafune K Human pluripotent stem cell-derived erythropoietin-producing cells ameliorate renal anemia in mice Human pluripotent stem cell-derived erythropoietin-producing cells ameliorate renal anemia in mice Human pluripotent stem cell-derived erythropoietin-producing cells ameliorate renal anemia in mice Science Translational Medicine, 27;9, 409 Science Translational Medicine, 27;9, 409 Science Translational Medicine, 27;9, 409 2017/09 Refereed English Research paper(scientific journal) Disclose to all
Matsuno K, Mae SI, Okada C, Nakamura M, Watanabe A, Toyoda T, Uchida E, Osafune K Matsuno K, Mae SI, Okada C, Nakamura M, Watanabe A, Toyoda T, Uchida E, Osafune K Redefining definitive endoderm subtypes by robust induction of human induced pluripotent stem cells. Redefining definitive endoderm subtypes by robust induction of human induced pluripotent stem cells. Redefining definitive endoderm subtypes by robust induction of human induced pluripotent stem cells. Differentiation, 92, 5, 281-290 Differentiation, 92, 5, 281-290 Differentiation, 92, 5, 281-290 2016/12 Refereed Disclose to all
Ikeda K, Mizoro Y, Ameku T, Nomiya Y, Mae SI, Matsui S, Kuchitsu Y, Suzuki C, Hamaoka-Okamoto A, Yahata T, Sone M, Okita K, Watanabe A, Osafune K Ikeda K, Mizoro Y, Ameku T, Nomiya Y, Mae SI, Matsui S, Kuchitsu Y, Suzuki C, Hamaoka-Okamoto A, Yahata T, Sone M, Okita K, Watanabe A, Osafune K Ikeda K, Mizoro Y, Ameku T, Nomiya Y, Mae SI, Matsui S, Kuchitsu Y, Suzuki C, Hamaoka-Okamoto A, Yahata T, Sone M, Okita K, Watanabe A, Osafune K Transcriptional Analysis of Intravenous Immunoglobulin Resistance in Kawasaki Disease Using an Induced Pluripotent Stem Cell Disease Model. Transcriptional Analysis of Intravenous Immunoglobulin Resistance in Kawasaki Disease Using an Induced Pluripotent Stem Cell Disease Model. Transcriptional Analysis of Intravenous Immunoglobulin Resistance in Kawasaki Disease Using an Induced Pluripotent Stem Cell Disease Model. Circulation Journal, 81, 1, 110-118 Circulation Journal, 81, 1, 110-118 Circulation Journal, 81, 1, 110-118 2016/12 Refereed English Research paper(scientific journal) Disclose to all
Ameku T, Taura D, Sone M, Numata T, Nakamura M, Shiota F, Toyoda T, Matsui S, Araoka T, Yasuno T, Mae SI, Kobayashi H, Kondo N, Kitaoka F, Amano N, Arai S, Ichisaka T, Matsuura N, Inoue S, Yamamoto T, Takahashi K, Asaka I, Yamada Y, Ubara Y, Muso E, Fukatsu A, Watanabe A, Sato Y, Nakahata T, Mori Y, Koizumi A, Nakao K, Yamanaka S, Osafune K Ameku T, Taura D, Sone M, Numata T, Nakamura M, Shiota F, Toyoda T, Matsui S, Araoka T, Yasuno T, Mae SI, Kobayashi H, Kondo N, Kitaoka F, Amano N, Arai S, Ichisaka T, Matsuura N, Inoue S, Yamamoto T, Takahashi K, Asaka I, Yamada Y, Ubara Y, Muso E, Fukatsu A, Watanabe A, Sato Y, Nakahata T, Mori Y, Koizumi A, Nakao K, Yamanaka S, Osafune K Identification of MMP1 as a novel risk factor for intracranial aneurysms in ADPKD using iPSC models. Identification of MMP1 as a novel risk factor for intracranial aneurysms in ADPKD using iPSC models. Identification of MMP1 as a novel risk factor for intracranial aneurysms in ADPKD using iPSC models. Scientific Reports, 6, 30013 Scientific Reports, 6, 30013 Scientific Reports, 6, 30013 2016/07 Refereed English Research paper(scientific journal) Disclose to all
Toyohara T, Mae SI, Sueta SI, Inoue T, Yamagishi Y, Kawamoto T, Kasahara T, Hoshina A, Toyoda T, Tanaka H, Araoka T, Sato-Otsubo A, Takahashi K, Sato Y, Yamaji N, Ogawa S, Yamanaka S, Osafune K Toyohara T, Mae SI, Sueta SI, Inoue T, Yamagishi Y, Kawamoto T, Kasahara T, Hoshina A, Toyoda T, Tanaka H, Araoka T, Sato-Otsubo A, Takahashi K, Sato Y, Yamaji N, Ogawa S, Yamanaka S, Osafune K Cell therapy using human induced pluripotent stem cell-derived renal progenitors ameliorates acute kidney injury in mice. Cell therapy using human induced pluripotent stem cell-derived renal progenitors ameliorates acute kidney injury in mice. Cell therapy using human induced pluripotent stem cell-derived renal progenitors ameliorates acute kidney injury in mice. Stem Cells Translational Medicine, 4, 9, 980-992 Stem Cells Translational Medicine, 4, 9, 980-992 Stem Cells Translational Medicine, 4, 9, 980-992 2015/09 Refereed English Research paper(scientific journal) Disclose to all
Mae S, Osafune K Mae S, Osafune K Mae S, Osafune K Kidney regeneration from human iPSCs. Kidney regeneration from human iPSCs. Kidney regeneration from human iPSCs. Current Opinion in Organ Transplantation, 20, 2, 171-177 Current Opinion in Organ Transplantation, 20, 2, 171-177 Current Opinion in Organ Transplantation, 20, 2, 171-177 2015/04 Refereed English Research paper(scientific journal) Disclose to all
Toyoda T, Mae S, Tanaka H, Kondo Y, Funato M, Hosokawa Y, Sudo T, Kawaguchi Y, Osafune K Toyoda T, Mae S, Tanaka H, Kondo Y, Funato M, Hosokawa Y, Sudo T, Kawaguchi Y, Osafune K Toyoda T, Mae S, Tanaka H, Kondo Y, Funato M, Hosokawa Y, Sudo T, Kawaguchi Y, Osafune K Cell aggregation optimizes the differentiation of human ESCs and iPSCs into pancreatic bud-like progenitor cells. Cell aggregation optimizes the differentiation of human ESCs and iPSCs into pancreatic bud-like progenitor cells. Cell aggregation optimizes the differentiation of human ESCs and iPSCs into pancreatic bud-like progenitor cells. Stem Cell Research, 14, 2, 185-197 Stem Cell Research, 14, 2, 185-197 Stem Cell Research, 14, 2, 185-197 2015/03 Refereed English Research paper(scientific journal) Disclose to all
Gotoh S, Ito I, Nagasaki T, Yamamoto Y, Konishi S, Korogi Y, Matsumoto H, Muro S, Hirai T, Funato M, Mae S, Toyoda T, Sato-Otsubo A, Ogawa S, Osafune K, Mishima M Gotoh S, Ito I, Nagasaki T, Yamamoto Y, Konishi S, Korogi Y, Matsumoto H, Muro S, Hirai T, Funato M, Mae S, Toyoda T, Sato-Otsubo A, Ogawa S, Osafune K, Mishima M Gotoh S, Ito I, Nagasaki T, Yamamoto Y, Konishi S, Korogi Y, Matsumoto H, Muro S, Hirai T, Funato M, Mae S, Toyoda T, Sato-Otsubo A, Ogawa S, Osafune K, Mishima M Generation of alveolar epithelial spheroids via isolated progenitor cells from human pluripotent stem cells. Generation of alveolar epithelial spheroids via isolated progenitor cells from human pluripotent stem cells. Generation of alveolar epithelial spheroids via isolated progenitor cells from human pluripotent stem cells. Stem Cell Reports, 3, 3, 394-403 Stem Cell Reports, 3, 3, 394-403 Stem Cell Reports, 3, 3, 394-403 2014/09 Refereed English Research paper(scientific journal) Disclose to all
Araoka T, Mae S, Kurose Y, Uesugi M, Ohta A, Yamanaka S, Osafune K Araoka T, Mae S, Kurose Y, Uesugi M, Ohta A, Yamanaka S, Osafune K Araoka T, Mae S, Kurose Y, Uesugi M, Ohta A, Yamanaka S, Osafune K Efficient and rapid induction of human iPSCs/ESCs into nephrogenic intermediate mesoderm using small molecule-based differentiation methods Efficient and rapid induction of human iPSCs/ESCs into nephrogenic intermediate mesoderm using small molecule-based differentiation methods Efficient and rapid induction of human iPSCs/ESCs into nephrogenic intermediate mesoderm using small molecule-based differentiation methods PLoS One, 9, 1 PLoS One, 9, 1 PLoS One, 9, 1 2014/01 Refereed English Research paper(scientific journal) Disclose to all
Mae S, Shono A, Shiota F, Yasuno T, Kajiwara M, Gotoda-Nishimura N, Arai S, Sato-Otubo A, Toyoda T, Takahashi K, Nakayama N, Cowan CA, Aoi T, Ogawa S, McMahon AP, Yamanaka S, Osafune K Mae S, Shono A, Shiota F, Yasuno T, Kajiwara M, Gotoda-Nishimura N, Arai S, Sato-Otubo A, Toyoda T, Takahashi K, Nakayama N, Cowan CA, Aoi T, Ogawa S, McMahon AP, Yamanaka S, Osafune K Mae S, Shono A, Shiota F, Yasuno T, Kajiwara M, Gotoda-Nishimura N, Arai S, Sato-Otubo A, Toyoda T, Takahashi K, Nakayama N, Cowan CA, Aoi T, Ogawa S, McMahon AP, Yamanaka S, Osafune K Monitoring and robust induction of nephrogenic intermediate mesoderm from human pluripotent stem cells Monitoring and robust induction of nephrogenic intermediate mesoderm from human pluripotent stem cells Monitoring and robust induction of nephrogenic intermediate mesoderm from human pluripotent stem cells Nature Communications, 4, 1367 Nature Communications, 4, 1367 Nature Communications, 4, 1367 2013 Refereed English Research paper(scientific journal) Disclose to all

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Title language:
Conference Activities & Talks
Title Title(Japanese) Title(English) Conference Conference(Japanese) Conference(English) Promotor Promotor(Japanese) Promotor(English) Date Language Assortment Disclose
ヒトiPS細胞から三次元構造を有する後腎尿管芽への分化誘導法の確立 ヒトiPS細胞から三次元構造を有する後腎尿管芽への分化誘導法の確立 第56回日本腎臓学会学術総会 第56回日本腎臓学会学術総会 2013/05/10 Japanese Oral presentation(general) Disclose to all
ヒトiPS細胞から三次元構造を有する後腎尿管芽への分化誘導法の確立 ヒトiPS細胞から三次元構造を有する後腎尿管芽への分化誘導法の確立 第12回日本再生医療学会総会 第12回日本再生医療学会総会 2013/03/22 Japanese Oral presentation(general) Disclose to all
ヒトiPS細胞から腎構成細胞に分化しうる中間中胚葉への高効率分化誘導法の確立 ヒトiPS細胞から腎構成細胞に分化しうる中間中胚葉への高効率分化誘導法の確立 第3回分子腎臓フォーラム 第3回分子腎臓フォーラム 2012/09/01 Japanese Oral presentation(general) Disclose to all
Monitoring and robust induction of intermediate mesoderm from human iPSCs and ESCs Monitoring and robust induction of intermediate mesoderm from human iPSCs and ESCs Monitoring and robust induction of intermediate mesoderm from human iPSCs and ESCs ISSCR 10th Annual Meeting ISSCR 10th Annual Meeting ISSCR 10th Annual Meeting 2012/06/14 English Poster presentation Disclose to all
ヒトiPS細胞から腎構成細胞に分化しうる中間中胚葉への高効率分化誘導法の確立 ヒトiPS細胞から腎構成細胞に分化しうる中間中胚葉への高効率分化誘導法の確立 第55回日本腎臓学会学術総会 第55回日本腎臓学会学術総会 2012/06/03 Japanese Oral presentation(general) Disclose to all
ヒト多能性幹細胞から腎臓系譜に分化する中間中胚葉細胞の高効率な分化誘導法の確立 ヒト多能性幹細胞から腎臓系譜に分化する中間中胚葉細胞の高効率な分化誘導法の確立 日本組織培養学会第85回大会 日本組織培養学会第85回大会 2012/05/17 Japanese Oral presentation(general) Disclose to all
Induction and monitoring of intermediate mesoderm from human iPSCs and ESCs Induction and monitoring of intermediate mesoderm from human iPSCs and ESCs Induction and monitoring of intermediate mesoderm from human iPSCs and ESCs ISSCR 9th Annual Meeting ISSCR 9th Annual Meeting ISSCR 9th Annual Meeting 2011/06/15 English Poster presentation Disclose to all
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Books etc
Author Author(Japanese) Author(English) Title Title(Japanese) Title(English) Publisher Publisher(Japanese) Publisher(English) Publication date Language Type Disclose
奥村詩織、前伸一、長船健二 奥村詩織、前伸一、長船健二 Current Therapy 2018 Vol.36 No.3 Current Therapy 2018 Vol.36 No.3 株式会社ライフメディコム 株式会社ライフメディコム 2018 Contributor Disclose to all
前 伸一 前 伸一 Nephrology Frontier 14(2) Nephrology Frontier 14(2) メディカルレビュー社 メディカルレビュー社 2015 Contributor Disclose to all
前 伸一、長船健二 前 伸一、長船健二 医学のあゆみ 252(2) 医学のあゆみ 252(2) 医歯薬出版 医歯薬出版 2015 Contributor Disclose to all
前伸一、沖田圭介、長船健二 前伸一、沖田圭介、長船健二 遺伝子 遺伝子 技術情報協会 技術情報協会 2014 Contributor Disclose to all
前伸一、長船健二 前伸一、長船健二 iPS 細胞研究最前線 iPS 細胞研究最前線 医歯薬出版 医歯薬出版 2014 Contributor Disclose to all
笠原朋子、前伸一、長船健二 笠原朋子、前伸一、長船健二 医学のあゆみ 248(2) 医学のあゆみ 248(2) 医歯薬出版 医歯薬出版 2014 Contributor Disclose to all
前伸一、荒岡利和、長船健二 前伸一、荒岡利和、長船健二 分子腎臓病学実験操作法 分子腎臓病学実験操作法 中外医学社 中外医学社 2013 Contributor Disclose to all
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Patents
Inventor(s) Inventor(s) (Japanese) Inventor(s) (English) Title Title(Japanese) Title(English) Stage Patent number Date Disclose
Osafune K, Mae S, Ryosaka M Osafune K, Mae S, Ryosaka M Method for generating Ureteric Bud-like Tissues Method for generating Ureteric Bud-like Tissues 特許出願 特願62/587693 2017/11/17 Disclose to all
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Awards
Title(Japanese) Title(English) Organization name(Japanese) Organization name(English) Date
日本組織培養学会第85 回大会 奨励賞 日本組織培養学会 2012/05/18
The 9th International Society for Stem cell Research (ISSCR) Travel Award International Society for Stem cell Research (ISSCR) 2011/06/15
第3回分子腎臓フォーラム優秀賞 分子腎臓フォーラム 2012/09/01
第56回日本腎臓学会学術総会優秀演題賞 日本腎臓学会 2013/05/10
External funds: competitive funds and Grants-in-Aid for Scientific Research (Kakenhi)
Type Position Title(Japanese) Title(English) Period
特別研究員奨励費 Representative ヒトiPS細胞から中間中胚葉の分化誘導 2011-2013
若手研究(B) Representative ヒトiPS細胞を用いた難治遺伝性腎疾患に対する新規病態モデルの開発 (平成29年度分) 2017/04/01-2018/03/31
若手研究(B) Representative ヒトiPS細胞から腎臓に分化しうる原始線条の作製 2015/04/01-2017/03/31
若手研究(B) Representative ヒトiPS細胞を用いた難治遺伝性腎疾患に対する新規病態モデルの開発 (平成30年度分) 2018/04/01-2019/03/31
基盤研究(C) Representative ヒトiPS細胞に由来する尿管芽オルガノイドの拡大培養法の開発 2019/04/01-2022/03/31