服部 雅一

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Name(Kanji/Kana/Abecedarium Latinum)
服部 雅一/ハットリ マサカズ/Hattori, Masakazu
Primary Affiliation(Org1/Job title)
Graduate Schools Medicine/Program-Specific Professor
Faculty
Org1 Job title
医学部
Academic Degree
Field(Japanese) Field(English) University(Japanese) University(English) Method
獣医学修士 北海道大学
博士(獣医学) 北海道大学
researchmap URL
https://researchmap.jp/read0051943
Research Topics
(Japanese)
免疫老化誘導機構の解明とその制御
(English)
Study on Immunosenescence and its regulation
Overview of the research
(Japanese)
加齢に伴う免疫系、特にT細胞の機能低下・変容は癌や感染症リスクの増大のみならず慢性炎症性病態や自己免疫疾患の発症につながっていると考えられてきたが、その詳細なメカニズムは長い間不明であった。我々の研究室では加齢に伴い増加する炎症性状を有するT細胞集団を同定し、老化関連T細胞(senescence-associated T:SA-T細胞) と名付けた。現在、この細胞集団による自己免疫疾患やII型糖尿病などの慢性炎症性病態との関連性に調べるとともに、その制御機構を明らかにし、これらの疾患に対する新しい治療薬の創出をめざし研究を行っている。
(English)
Immunosenescence is age-associated changes in the immunological functions, including diminished acquired immunity against infection, pro-inflammatory traits, and increased risk of autoimmunity. The proportions of memory-phenotype T cells in the peripheral T-cell population steadily increase with age, but the relationship between this change and immunosenescent phenotypes remains elusive. Recently, we identified a minor memory-phenotype CD4+ T-cell subpopulation that constitutively expressed PD-1 and CD153 as a bona fide age-dependent T-cell population; we termed these cells senescence-associated T (SA-T) cells. SA-T cells exhibit characteristic features of cellular senescence, with defective T-cell receptor-mediated proliferation and T-cell cytokine production. However, upon T-cell receptor stimulation, SA-T cells secrete abundant atypical pro-inflammatory cytokines such as osteopontin and chemokines, reminiscent of the SA-secretory phenotype. In addition to aging, SA-T cells accumulate and cause persistent inflammation in tissues following a wide range of insults including immune complex deposition, metabolic stresses, vascular damages, and tumors. In this review, we summarize the recent understanding of immunosenescence with particular focus on SA-T cells and their role in various age-related disorders.
Fields of research (key words)
Key words(Japanese) Key words(English)
免疫老化, 自己免疫疾患 Immunosenescence、autoimmune diseases
Published Papers
Author Author(Japanese) Author(English) Title Title(Japanese) Title(English) Bibliography Bibliography(Japanese) Bibliography(English) Publication date Refereed paper Language Publishing type Disclose
HATTORI Masakazu 服部 雅一 HATTORI Masakazu The impact of senescence-associated T cells on immunosenescence and age-related disorders. The impact of senescence-associated T cells on immunosenescence and age-related disorders. The impact of senescence-associated T cells on immunosenescence and age-related disorders. Inflammation and Regeneration, 24, 38 Inflammation and Regeneration, 24, 38 Inflammation and Regeneration, 24, 38 2018/12 Refereed English Research paper(scientific journal) Disclose to all
Ito K, Nakajima A, Fukushima Y, Suzuki K, Sakamoto K, Hamazaki Y, Ogasawara K, Minato N, Hattori M Ito K, Nakajima A, Fukushima Y, Suzuki K, Sakamoto K, Hamazaki Y, Ogasawara K, Minato N, Hattori M Ito K, Nakajima A, Fukushima Y, Suzuki K, Sakamoto K, Hamazaki Y, Ogasawara K, Minato N, Hattori M The potential role of Osteopontin in the maintenance of commensal bacteria homeostasis in the intestine. The potential role of Osteopontin in the maintenance of commensal bacteria homeostasis in the intestine. The potential role of Osteopontin in the maintenance of commensal bacteria homeostasis in the intestine. PloS one, 12, 3, e0173629 PloS one, 12, 3, e0173629 PloS one, 12, 3, e0173629 2017 Refereed Disclose to all
Sakamoto K, Fukushima Y, Ito K, Matsuda M, Nagata S, Minato N, Hattori M Sakamoto K, Fukushima Y, Ito K, Matsuda M, Nagata S, Minato N, Hattori M Sakamoto K, Fukushima Y, Ito K, Matsuda M, Nagata S, Minato N, Hattori M Osteopontin in Spontaneous Germinal Centers Inhibits Apoptotic Cell Engulfment and Promotes Anti-Nuclear Antibody Production in Lupus-Prone Mice. Osteopontin in Spontaneous Germinal Centers Inhibits Apoptotic Cell Engulfment and Promotes Anti-Nuclear Antibody Production in Lupus-Prone Mice. Osteopontin in Spontaneous Germinal Centers Inhibits Apoptotic Cell Engulfment and Promotes Anti-Nuclear Antibody Production in Lupus-Prone Mice. Journal of immunology (Baltimore, Md. : 1950), 197, 6, 2177-2186 Journal of immunology (Baltimore, Md. : 1950), 197, 6, 2177-2186 Journal of immunology (Baltimore, Md. : 1950), 197, 6, 2177-2186 2016/09 Refereed Disclose to all
Tahir S, Fukushima Y, Sakamoto K, Sato K, Fujita H, Inoue J, Uede T, Hamazaki Y, Hattori M, Minato N Tahir S, Fukushima Y, Sakamoto K, Sato K, Fujita H, Inoue J, Uede T, Hamazaki Y, Hattori M, Minato N Tahir S, Fukushima Y, Sakamoto K, Sato K, Fujita H, Inoue J, Uede T, Hamazaki Y, Hattori M, Minato N A CD153+CD4+ T follicular cell population with cell-senescence features plays a crucial role in lupus pathogenesis via osteopontin production. A CD153+CD4+ T follicular cell population with cell-senescence features plays a crucial role in lupus pathogenesis via osteopontin production. A CD153+CD4+ T follicular cell population with cell-senescence features plays a crucial role in lupus pathogenesis via osteopontin production. Journal of immunology (Baltimore, Md. : 1950), 194, 12, 5725-5735 Journal of immunology (Baltimore, Md. : 1950), 194, 12, 5725-5735 Journal of immunology (Baltimore, Md. : 1950), 194, 12, 5725-5735 2015/06 Refereed Disclose to all
Hattori M, Minato N Hattori M, Minato N Hattori M, Minato N [T-cell senescence and autoimmune diseases]. [T-cell senescence and autoimmune diseases]. [T-cell senescence and autoimmune diseases]. Arerugi = [Allergy], 64, 2, 110-118 Arerugi = [Allergy], 64, 2, 110-118 Arerugi = [Allergy], 64, 2, 110-118 2015/02 Refereed Disclose to all
4. Akimoto M, Takeda A, Matsushita O, Inoue J, Sakamoto K, Hattori M, Kounoike N, Uchinuma Akimoto M, Takeda A, Matsushita O, Inoue J, Sakamoto K, Hattori M, Kounoike N, Uchinuma E 4. Akimoto M, Takeda A, Matsushita O, Inoue J, Sakamoto K, Hattori M, Kounoike N, Uchinuma Effects of CB-VEGF-A injection in rat flap models for improved survival. Effects of CB-VEGF-A injection in rat flap models for improved survival. Effects of CB-VEGF-A injection in rat flap models for improved survival. Plastic Reconst. Surg, 131, 4, 717-725 Plastic Reconst. Surg, 131, 4, 717-725 Plastic Reconst. Surg, 131, 4, 717-725 2013/04 Refereed Disclose to all
K. Hayashida; K. Kajino; M. Hattori; M. Wallace; I. Morrison; M.I. Greene; C. Sugimoto K. Hayashida; K. Kajino; M. Hattori; M. Wallace; I. Morrison; M.I. Greene; C. Sugimoto K. Hayashida; K. Kajino; M. Hattori; M. Wallace; I. Morrison; M.I. Greene; C. Sugimoto MDM2 regulates a novel form of incomplete neoplastic transformation of Theileria parva infected lymphocytes MDM2 regulates a novel form of incomplete neoplastic transformation of Theileria parva infected lymphocytes MDM2 regulates a novel form of incomplete neoplastic transformation of Theileria parva infected lymphocytes Experimental and Molecular Pathology, 94, 1, 228-238 Experimental and Molecular Pathology, 94, 1, 228-238 Experimental and Molecular Pathology, 94, 1, 228-238 2013/02 Refereed English Disclose to all
Y. Shimizu; Y. Hamazaki; M. Hattori; K. Doi; N. Terada; T. Kobayashi; Y. Toda; T. Yamasaki; T. Inoue; Y. Kajita; A. Maeno; T. Kamba; Y. Mikami; T. Kamoto; T. Yamada; T. Kanno; K. Yoshikawa; O. Ogawa; N. Minato; E. Nakamura Y. Shimizu; Y. Hamazaki; M. Hattori; K. Doi; N. Terada; T. Kobayashi; Y. Toda; T. Yamasaki; T. Inoue; Y. Kajita; A. Maeno; T. Kamba; Y. Mikami; T. Kamoto; T. Yamada; T. Kanno; K. Yoshikawa; O. Ogawa; N. Minato; E. Nakamura Y. Shimizu; Y. Hamazaki; M. Hattori; K. Doi; N. Terada; T. Kobayashi; Y. Toda; T. Yamasaki; T. Inoue; Y. Kajita; A. Maeno; T. Kamba; Y. Mikami; T. Kamoto; T. Yamada; T. Kanno; K. Yoshikawa; O. Ogawa; N. Minato; E. Nakamura SPA-1 controls the invasion and metastasis of human prostate cancer SPA-1 controls the invasion and metastasis of human prostate cancer SPA-1 controls the invasion and metastasis of human prostate cancer Cancer Science, 102, 4, 828-836 Cancer Science, 102, 4, 828-836 Cancer Science, 102, 4, 828-836 2011/04 Refereed English Disclose to all
K. Hayashida; M. Hattori; R. Nakao; Y. Tanaka; J.-Y. Kim; N. Inoue; V. Nene; C. Sugimoto K. Hayashida; M. Hattori; R. Nakao; Y. Tanaka; J.-Y. Kim; N. Inoue; V. Nene; C. Sugimoto K. Hayashida; M. Hattori; R. Nakao; Y. Tanaka; J.-Y. Kim; N. Inoue; V. Nene; C. Sugimoto A schizont-derived protein, TpSCOP, is involved in the activation of NF-κB in Theileria parva-infected lymphocytes A schizont-derived protein, TpSCOP, is involved in the activation of NF-κB in Theileria parva-infected lymphocytes A schizont-derived protein, TpSCOP, is involved in the activation of NF-κB in Theileria parva-infected lymphocytes Molecular and Biochemical Parasitology, 174, 1, 8-17 Molecular and Biochemical Parasitology, 174, 1, 8-17 Molecular and Biochemical Parasitology, 174, 1, 8-17 2010/11 Refereed English Disclose to all
Y. Katayama; M. Sekai; M. Hattori; I. Miyoshi; Y. Hamazaki; N. Minato Y. Katayama; M. Sekai; M. Hattori; I. Miyoshi; Y. Hamazaki; N. Minato Y. Katayama; M. Sekai; M. Hattori; I. Miyoshi; Y. Hamazaki; N. Minato Rap signaling is crucial for the competence of IL-7 response and the development of B-lineage cells Rap signaling is crucial for the competence of IL-7 response and the development of B-lineage cells Rap signaling is crucial for the competence of IL-7 response and the development of B-lineage cells Blood, 114, 9, 1768-1775 Blood, 114, 9, 1768-1775 Blood, 114, 9, 1768-1775 2009/08 Refereed English Disclose to all
S. Hara; C. Nakaseko; S. Yamasaki; M. Hattori; J.L. Bos; Y. Saito; N. Minato; T. Saito S. Hara; C. Nakaseko; S. Yamasaki; M. Hattori; J.L. Bos; Y. Saito; N. Minato; T. Saito S. Hara; C. Nakaseko; S. Yamasaki; M. Hattori; J.L. Bos; Y. Saito; N. Minato; T. Saito Involvement of Rap-1 activation and early termination of immune synapse in CTLA-4-mediated negative signal Involvement of Rap-1 activation and early termination of immune synapse in CTLA-4-mediated negative signal Involvement of Rap-1 activation and early termination of immune synapse in CTLA-4-mediated negative signal Hematology, 14, 3, 150-158 Hematology, 14, 3, 150-158 Hematology, 14, 3, 150-158 2009/06 Refereed English Disclose to all
Y. Nakajima; M. Moriyama; M. Hattori; N. Minato; S. Nakanishi Y. Nakajima; M. Moriyama; M. Hattori; N. Minato; S. Nakanishi Y. Nakajima; M. Moriyama; M. Hattori; N. Minato; S. Nakanishi Isolation of ON bipolar cell genes via hrGFP-coupled cell enrichment using the mGluR6 promoter Isolation of ON bipolar cell genes via hrGFP-coupled cell enrichment using the mGluR6 promoter Isolation of ON bipolar cell genes via hrGFP-coupled cell enrichment using the mGluR6 promoter Journal of Biochemistry, 145, 6, 811-818 Journal of Biochemistry, 145, 6, 811-818 Journal of Biochemistry, 145, 6, 811-818 2009/06 Refereed English Disclose to all
N. Minato; M. Hattori N. Minato; M. Hattori N. Minato; M. Hattori Spa-1 (Sipa1) and rap signaling in leukemia and cancer metastasis Spa-1 (Sipa1) and rap signaling in leukemia and cancer metastasis Spa-1 (Sipa1) and rap signaling in leukemia and cancer metastasis Cancer Science, 100, 1, 17-23 Cancer Science, 100, 1, 17-23 Cancer Science, 100, 1, 17-23 2009/01 Refereed English Disclose to all
K. Kometani; M. Moriyama; Y. Nakashima; Y. Katayama; S.-F. Wang; S. Yamasaki; T. Saito; M. Hattori; N. Minato K. Kometani; M. Moriyama; Y. Nakashima; Y. Katayama; S.-F. Wang; S. Yamasaki; T. Saito; M. Hattori; N. Minato K. Kometani; M. Moriyama; Y. Nakashima; Y. Katayama; S.-F. Wang; S. Yamasaki; T. Saito; M. Hattori; N. Minato Essential role of Rap signal in pre-TCR-mediated {beta}-selection checkpoint in {alpha}{beta} T-cell development Essential role of Rap signal in pre-TCR-mediated {beta}-selection checkpoint in {alpha}{beta} T-cell development Essential role of Rap signal in pre-TCR-mediated {beta}-selection checkpoint in {alpha}{beta} T-cell development Blood, 112, 12, 4565-4573 Blood, 112, 12, 4565-4573 Blood, 112, 12, 4565-4573 2008/12 Refereed English Disclose to all
S.-F. Wang; M. Aoki; Y. Nakashima; Y. Shinozuka; H. Tanaka; M. Taniwaki; M. Hattori; N. Minato S.-F. Wang; M. Aoki; Y. Nakashima; Y. Shinozuka; H. Tanaka; M. Taniwaki; M. Hattori; N. Minato S.-F. Wang; M. Aoki; Y. Nakashima; Y. Shinozuka; H. Tanaka; M. Taniwaki; M. Hattori; N. Minato Development of notch-dependent T-cell leukemia by deregulated rapl signaling Development of notch-dependent T-cell leukemia by deregulated rapl signaling Development of notch-dependent T-cell leukemia by deregulated rapl signaling Blood, 111, 5, 2878-2886 Blood, 111, 5, 2878-2886 Blood, 111, 5, 2878-2886 2008/03 Refereed English Disclose to all
T. Kitamura; K. Kometani; H. Hashida; A. Matsunaga; H. Miyoshi; H. Hosogi; M. Aoki; M. Oshima; M. Hattori; A. Takabayashi; N. Minato; M.M. Taketo T. Kitamura; K. Kometani; H. Hashida; A. Matsunaga; H. Miyoshi; H. Hosogi; M. Aoki; M. Oshima; M. Hattori; A. Takabayashi; N. Minato; M.M. Taketo T. Kitamura; K. Kometani; H. Hashida; A. Matsunaga; H. Miyoshi; H. Hosogi; M. Aoki; M. Oshima; M. Hattori; A. Takabayashi; N. Minato; M.M. Taketo SMAD4-deficient intestinal tumors recruit CCR1<sup>+</sup> myeloid cells that promote invasion SMAD4-deficient intestinal tumors recruit CCR1<sup>+</sup> myeloid cells that promote invasion SMAD4-deficient intestinal tumors recruit CCR1<sup>+</sup> myeloid cells that promote invasion Nature Genetics, 39, 4, 467-475 Nature Genetics, 39, 4, 467-475 Nature Genetics, 39, 4, 467-475 2007/04 Refereed English Disclose to all
N. Minato; K. Kometani; M. Hattori N. Minato; K. Kometani; M. Hattori N. Minato; K. Kometani; M. Hattori Regulation of Immune Responses and Hematopoiesis by the Rap1 Signal Regulation of Immune Responses and Hematopoiesis by the Rap1 Signal Regulation of Immune Responses and Hematopoiesis by the Rap1 Signal Advances in Immunology, 93, 229-264 Advances in Immunology, 93, 229-264 Advances in Immunology, 93, 229-264 2007 Refereed English Disclose to all
K. Kometani; M. Aoki; S. Kawamata; Y. Shinozuka; T. Era; M. Taniwaki; M. Hattori; N. Minato K. Kometani; M. Aoki; S. Kawamata; Y. Shinozuka; T. Era; M. Taniwaki; M. Hattori; N. Minato K. Kometani; M. Aoki; S. Kawamata; Y. Shinozuka; T. Era; M. Taniwaki; M. Hattori; N. Minato Role of SPA-1 in phenotypes of chronic myelogenous leukemia induced by BCR-ABL-expressing hematopoietic progenitors in a mouse model Role of SPA-1 in phenotypes of chronic myelogenous leukemia induced by BCR-ABL-expressing hematopoietic progenitors in a mouse model Role of SPA-1 in phenotypes of chronic myelogenous leukemia induced by BCR-ABL-expressing hematopoietic progenitors in a mouse model Cancer Research, 66, 20, 9967-9976 Cancer Research, 66, 20, 9967-9976 Cancer Research, 66, 20, 9967-9976 2006/10 Refereed English Disclose to all
D. Ishida; L. Su; A. Tamura; Y. Katayama; Y. Kawai; S.-F. Wang; M. Taniwaki; Y. Hamazaki; M. Hattori; N. Minato D. Ishida; L. Su; A. Tamura; Y. Katayama; Y. Kawai; S.-F. Wang; M. Taniwaki; Y. Hamazaki; M. Hattori; N. Minato D. Ishida; L. Su; A. Tamura; Y. Katayama; Y. Kawai; S.-F. Wang; M. Taniwaki; Y. Hamazaki; M. Hattori; N. Minato Rap1 Signal Controls B Cell Receptor Repertoire and Generation of Self-Reactive B1a Cells Rap1 Signal Controls B Cell Receptor Repertoire and Generation of Self-Reactive B1a Cells Rap1 Signal Controls B Cell Receptor Repertoire and Generation of Self-Reactive B1a Cells Immunity, 24, 4, 417-427 Immunity, 24, 4, 417-427 Immunity, 24, 4, 417-427 2006/04 Refereed English Disclose to all
A. Jin; T. Kurosu; K. Tsuji; D. Mizuchi; A. Arai; H. Fujita; M. Hattori; N. Minato; O. Miura A. Jin; T. Kurosu; K. Tsuji; D. Mizuchi; A. Arai; H. Fujita; M. Hattori; N. Minato; O. Miura A. Jin; T. Kurosu; K. Tsuji; D. Mizuchi; A. Arai; H. Fujita; M. Hattori; N. Minato; O. Miura BCR/ABL and IL-3 activate Rap1 to stimulate the B-Raf/MEK/Erk and Akt signaling pathways and to regulate proliferation, apoptosis, and adhesion BCR/ABL and IL-3 activate Rap1 to stimulate the B-Raf/MEK/Erk and Akt signaling pathways and to regulate proliferation, apoptosis, and adhesion BCR/ABL and IL-3 activate Rap1 to stimulate the B-Raf/MEK/Erk and Akt signaling pathways and to regulate proliferation, apoptosis, and adhesion Oncogene, 25, 31, 4332-4340 Oncogene, 25, 31, 4332-4340 Oncogene, 25, 31, 4332-4340 2006 Refereed English Disclose to all
K. Masuda; H. Kubagawa; T. Ikawa; C.-C. Chen; K. Kakugawa; M. Hattori; R. Kageyama; M.D. Cooper; N. Minato; Y. Katsura; H. Kawamoto K. Masuda; H. Kubagawa; T. Ikawa; C.-C. Chen; K. Kakugawa; M. Hattori; R. Kageyama; M.D. Cooper; N. Minato; Y. Katsura; H. Kawamoto K. Masuda; H. Kubagawa; T. Ikawa; C.-C. Chen; K. Kakugawa; M. Hattori; R. Kageyama; M.D. Cooper; N. Minato; Y. Katsura; H. Kawamoto Prethymic T-cell development defined by the expression of paired immunoglobulin-like receptors Prethymic T-cell development defined by the expression of paired immunoglobulin-like receptors Prethymic T-cell development defined by the expression of paired immunoglobulin-like receptors EMBO Journal, 24, 23, 4052-4060 EMBO Journal, 24, 23, 4052-4060 EMBO Journal, 24, 23, 4052-4060 2005/12 Refereed English Disclose to all
K. Murata; M. Hattori; N. Hirai; Y. Shinozuka; H. Hirata; R. Kageyama; T. Sakai; N. Minato K. Murata; M. Hattori; N. Hirai; Y. Shinozuka; H. Hirata; R. Kageyama; T. Sakai; N. Minato K. Murata; M. Hattori; N. Hirai; Y. Shinozuka; H. Hirata; R. Kageyama; T. Sakai; N. Minato Hes1 directly controls cell proliferation through the transcriptional repression of p27 <sup>Kip1</sup> Hes1 directly controls cell proliferation through the transcriptional repression of p27 <sup>Kip1</sup> Hes1 directly controls cell proliferation through the transcriptional repression of p27 <sup>Kip1</sup> Molecular and Cellular Biology, 25, 10, 4262-4271 Molecular and Cellular Biology, 25, 10, 4262-4271 Molecular and Cellular Biology, 25, 10, 4262-4271 2005/05 Refereed English Disclose to all
A. Farina; M. Hattori; J. Qin; Y. Nakatani; N. Minato; K. Ozato A. Farina; M. Hattori; J. Qin; Y. Nakatani; N. Minato; K. Ozato A. Farina; M. Hattori; J. Qin; Y. Nakatani; N. Minato; K. Ozato Bromodomain protein Brd4 binds to GTPase-activating SPA-1, modulating its activity and subcellular localization Bromodomain protein Brd4 binds to GTPase-activating SPA-1, modulating its activity and subcellular localization Bromodomain protein Brd4 binds to GTPase-activating SPA-1, modulating its activity and subcellular localization Molecular and Cellular Biology, 24, 20, 9059-9069 Molecular and Cellular Biology, 24, 20, 9059-9069 Molecular and Cellular Biology, 24, 20, 9059-9069 2004/10 Refereed English Disclose to all
K. Kometani; D. Ishida; M. Hattori; N. Minato K. Kometani; D. Ishida; M. Hattori; N. Minato K. Kometani; D. Ishida; M. Hattori; N. Minato Rap1 and SPA-1 in hematologic malignancy Rap1 and SPA-1 in hematologic malignancy Rap1 and SPA-1 in hematologic malignancy Trends in Molecular Medicine, 10, 8, 401-408 Trends in Molecular Medicine, 10, 8, 401-408 Trends in Molecular Medicine, 10, 8, 401-408 2004/08 Refereed English Disclose to all
Y. Noda; S. Horikawa; T. Furukawa; K. Hirai; Y. Katayama; T. Asai; M. Kuwahara; K. Katagiri; T. Kinashi; M. Hattori; N. Minato; S. Sasaki Y. Noda; S. Horikawa; T. Furukawa; K. Hirai; Y. Katayama; T. Asai; M. Kuwahara; K. Katagiri; T. Kinashi; M. Hattori; N. Minato; S. Sasaki Y. Noda; S. Horikawa; T. Furukawa; K. Hirai; Y. Katayama; T. Asai; M. Kuwahara; K. Katagiri; T. Kinashi; M. Hattori; N. Minato; S. Sasaki Aquaporin-2 trafficking is regulated by PDZ-domain containing protein SPA-1 Aquaporin-2 trafficking is regulated by PDZ-domain containing protein SPA-1 Aquaporin-2 trafficking is regulated by PDZ-domain containing protein SPA-1 FEBS Letters, 568, 1/3, 139-145 FEBS Letters, 568, 1/3, 139-145 FEBS Letters, 568, 1/3, 139-145 2004/06 Refereed English Disclose to all
M. Harazaki; Y. Kawai; L. Su; Y. Hamazaki; T. Nakahata; N. Minato; M. Hattori M. Harazaki; Y. Kawai; L. Su; Y. Hamazaki; T. Nakahata; N. Minato; M. Hattori M. Harazaki; Y. Kawai; L. Su; Y. Hamazaki; T. Nakahata; N. Minato; M. Hattori Specific recruitment of SPA-1 to the immunological synapse: Involvement of actin-bundling protein actinin Specific recruitment of SPA-1 to the immunological synapse: Involvement of actin-bundling protein actinin Specific recruitment of SPA-1 to the immunological synapse: Involvement of actin-bundling protein actinin Immunology Letters, 92, 3, 221-226 Immunology Letters, 92, 3, 221-226 Immunology Letters, 92, 3, 221-226 2004/04 Refereed English Disclose to all
M. Hattori; N. Minato M. Hattori; N. Minato M. Hattori; N. Minato Rap1 GTPase: Functions, Regulation, and Malignancy Rap1 GTPase: Functions, Regulation, and Malignancy Rap1 GTPase: Functions, Regulation, and Malignancy Journal of Biochemistry, 134, 4, 479-484 Journal of Biochemistry, 134, 4, 479-484 Journal of Biochemistry, 134, 4, 479-484 2003/10 Refereed English Disclose to all
K. Kakugawa; M. Hattori; N. Beauchemin; N. Minato K. Kakugawa; M. Hattori; N. Beauchemin; N. Minato K. Kakugawa; M. Hattori; N. Beauchemin; N. Minato Activation of CEA-CAM-1-mediated cell adhesion via CD98: Involvement of PKCδ Activation of CEA-CAM-1-mediated cell adhesion via CD98: Involvement of PKCδ Activation of CEA-CAM-1-mediated cell adhesion via CD98: Involvement of PKCδ FEBS Letters, 552, 2/3, 184-188 FEBS Letters, 552, 2/3, 184-188 FEBS Letters, 552, 2/3, 184-188 2003/09 Refereed English Disclose to all
D. Ishida; K. Kometani; H. Yang; K. Kakugawa; K. Masuda; K. Iwai; M. Suzuki; S. Itohara; T. Nakahata; H. Hiai; H. Kawamoto; M. Hattori; N. Minato D. Ishida; K. Kometani; H. Yang; K. Kakugawa; K. Masuda; K. Iwai; M. Suzuki; S. Itohara; T. Nakahata; H. Hiai; H. Kawamoto; M. Hattori; N. Minato D. Ishida; K. Kometani; H. Yang; K. Kakugawa; K. Masuda; K. Iwai; M. Suzuki; S. Itohara; T. Nakahata; H. Hiai; H. Kawamoto; M. Hattori; N. Minato Myeloproliferative stem cell disorders by deregulated Rap1 activation in SPA-1-deficient mice Myeloproliferative stem cell disorders by deregulated Rap1 activation in SPA-1-deficient mice Myeloproliferative stem cell disorders by deregulated Rap1 activation in SPA-1-deficient mice Cancer Cell, 4, 1, 55-65 Cancer Cell, 4, 1, 55-65 Cancer Cell, 4, 1, 55-65 2003/07 Refereed English Disclose to all
L. Su; M. Hattori; M. Moriyama; N. Murata; M. Harazaki; K. Kaibuchi; N. Minato L. Su; M. Hattori; M. Moriyama; N. Murata; M. Harazaki; K. Kaibuchi; N. Minato L. Su; M. Hattori; M. Moriyama; N. Murata; M. Harazaki; K. Kaibuchi; N. Minato AF-6 controls integrin-mediated cell adhesion by regulating Rap1 activation through the specific recruitment of Rap1GTP and SPA-1 AF-6 controls integrin-mediated cell adhesion by regulating Rap1 activation through the specific recruitment of Rap1GTP and SPA-1 AF-6 controls integrin-mediated cell adhesion by regulating Rap1 activation through the specific recruitment of Rap1GTP and SPA-1 Journal of Biological Chemistry, 278, 17, 15232-15238 Journal of Biological Chemistry, 278, 17, 15232-15238 Journal of Biological Chemistry, 278, 17, 15232-15238 2003/04 Refereed English Disclose to all
K. Katagiri; M. Hattori; N. Minato; T. Kinashi K. Katagiri; M. Hattori; N. Minato; T. Kinashi K. Katagiri; M. Hattori; N. Minato; T. Kinashi Rap1 functions as a key regulator of T-cell and antigen-presenting cell interactions and modulates T-cell responses Rap1 functions as a key regulator of T-cell and antigen-presenting cell interactions and modulates T-cell responses Rap1 functions as a key regulator of T-cell and antigen-presenting cell interactions and modulates T-cell responses Molecular and Cellular Biology, 22, 4, 1001-1015 Molecular and Cellular Biology, 22, 4, 1001-1015 Molecular and Cellular Biology, 22, 4, 1001-1015 2002/02 Refereed English Disclose to all
N. Ohno; A. Izawa; M. Hattori; R. Kageyama; T. Sudo N. Ohno; A. Izawa; M. Hattori; R. Kageyama; T. Sudo N. Ohno; A. Izawa; M. Hattori; R. Kageyama; T. Sudo dlk inhibits stem cell factor-induced colony formation of murine hematopoietic progenitors: Hes-1-independent effect dlk inhibits stem cell factor-induced colony formation of murine hematopoietic progenitors: Hes-1-independent effect dlk inhibits stem cell factor-induced colony formation of murine hematopoietic progenitors: Hes-1-independent effect Stem Cells, 19, 1, 71-79 Stem Cells, 19, 1, 71-79 Stem Cells, 19, 1, 71-79 2001 Refereed English Disclose to all
K. Suga; K. Katagiri; T. Kinashi; M. Harazaki; T. Iizuka; M. Hattori; N. Minato K. Suga; K. Katagiri; T. Kinashi; M. Harazaki; T. Iizuka; M. Hattori; N. Minato K. Suga; K. Katagiri; T. Kinashi; M. Harazaki; T. Iizuka; M. Hattori; N. Minato CD98 induces LFA-1-mediated cell adhesion in lymphoid cells via activation of Rap1 CD98 induces LFA-1-mediated cell adhesion in lymphoid cells via activation of Rap1 CD98 induces LFA-1-mediated cell adhesion in lymphoid cells via activation of Rap1 FEBS Letters, 489, 2-3, 249-253 FEBS Letters, 489, 2-3, 249-253 FEBS Letters, 489, 2-3, 249-253 2001 Refereed English Disclose to all
K. Katagiri; M. Hattori; N. Minato; S.-K. Irie; K. Takatsu; T. Kinashi K. Katagiri; M. Hattori; N. Minato; S.-K. Irie; K. Takatsu; T. Kinashi K. Katagiri; M. Hattori; N. Minato; S.-K. Irie; K. Takatsu; T. Kinashi Rap1 is a potent activation signal for leukocyte function-associated antigen 1 distinct from protein kinase C and phosphatidylinositol-3-OH kinase Rap1 is a potent activation signal for leukocyte function-associated antigen 1 distinct from protein kinase C and phosphatidylinositol-3-OH kinase Rap1 is a potent activation signal for leukocyte function-associated antigen 1 distinct from protein kinase C and phosphatidylinositol-3-OH kinase Molecular and Cellular Biology, 20, 6, 1956-1969 Molecular and Cellular Biology, 20, 6, 1956-1969 Molecular and Cellular Biology, 20, 6, 1956-1969 2000 Refereed English Disclose to all
K. Tomita; M. Hattori; E. Nakamura; S. Nakanishi; N. Minato; R. Kageyama K. Tomita; M. Hattori; E. Nakamura; S. Nakanishi; N. Minato; R. Kageyama K. Tomita; M. Hattori; E. Nakamura; S. Nakanishi; N. Minato; R. Kageyama The bHLH gene Hes1 is essential for expansion of early T cell precursors The bHLH gene Hes1 is essential for expansion of early T cell precursors The bHLH gene Hes1 is essential for expansion of early T cell precursors Genes and Development, 13, 9, 1203-1210 Genes and Development, 13, 9, 1203-1210 Genes and Development, 13, 9, 1203-1210 1999/05/01 Refereed English Disclose to all
T. Morimura; K.-O. Cho; Y. Kudo; Y. Hiramoto; K. Ohashi; M. Hattori; C. Sugimoto; M. Onuma T. Morimura; K.-O. Cho; Y. Kudo; Y. Hiramoto; K. Ohashi; M. Hattori; C. Sugimoto; M. Onuma T. Morimura; K.-O. Cho; Y. Kudo; Y. Hiramoto; K. Ohashi; M. Hattori; C. Sugimoto; M. Onuma Anti-viral and anti-tumor effects induced by an attenuated Marek\\'s disease virus in CD4- or CD8-deficient chickens Anti-viral and anti-tumor effects induced by an attenuated Marek\\'s disease virus in CD4- or CD8-deficient chickens Anti-viral and anti-tumor effects induced by an attenuated Marek\\'s disease virus in CD4- or CD8-deficient chickens Archives of Virology, 144, 9, 1809-1818 Archives of Virology, 144, 9, 1809-1818 Archives of Virology, 144, 9, 1809-1818 1999 Refereed English Disclose to all
N. Tsukamoto; M. Hattori; H. Yang; J.L. Bos; N. Minato N. Tsukamoto; M. Hattori; H. Yang; J.L. Bos; N. Minato N. Tsukamoto; M. Hattori; H. Yang; J.L. Bos; N. Minato Rap1 GTPase-activating protein SPA-1 negatively regulates cell adhesion Rap1 GTPase-activating protein SPA-1 negatively regulates cell adhesion Rap1 GTPase-activating protein SPA-1 negatively regulates cell adhesion Journal of Biological Chemistry, 274, 26, 18463-18469 Journal of Biological Chemistry, 274, 26, 18463-18469 Journal of Biological Chemistry, 274, 26, 18463-18469 1999 Refereed English Disclose to all
H. Kurachi; Y. Wada; N. Tsukamoto; M. Maeda; H. Kubota; M. Hattori; K. Iwai; N. Minato H. Kurachi; Y. Wada; N. Tsukamoto; M. Maeda; H. Kubota; M. Hattori; K. Iwai; N. Minato H. Kurachi; Y. Wada; N. Tsukamoto; M. Maeda; H. Kubota; M. Hattori; K. Iwai; N. Minato Human SPA-1 gene product selectively expressed in lymphoid tissues is a specific GTPase-activating protein for Rap1 and Rap2. Segregate expression profiles from a rap1GAP gene product Human SPA-1 gene product selectively expressed in lymphoid tissues is a specific GTPase-activating protein for Rap1 and Rap2. Segregate expression profiles from a rap1GAP gene product Human SPA-1 gene product selectively expressed in lymphoid tissues is a specific GTPase-activating protein for Rap1 and Rap2. Segregate expression profiles from a rap1GAP gene product Journal of Biological Chemistry, 272, 44, 28081-28088 Journal of Biological Chemistry, 272, 44, 28081-28088 Journal of Biological Chemistry, 272, 44, 28081-28088 1997 Refereed English Disclose to all
K. Okada; Y. Tanaka; K. Murakami; S. Chiba; T. Morimura; M. Hattori; M. Goryo; M. Onuma K. Okada; Y. Tanaka; K. Murakami; S. Chiba; T. Morimura; M. Hattori; M. Goryo; M. Onuma K. Okada; Y. Tanaka; K. Murakami; S. Chiba; T. Morimura; M. Hattori; M. Goryo; M. Onuma Phenotype analysis of lymphoid cells in Marek\\'s disease of CD4<sup>+</sup> or CD8<sup>+</sup> T-cell-deficient chickens: Occurrence of double negative T-cell tumour Phenotype analysis of lymphoid cells in Marek\\'s disease of CD4<sup>+</sup> or CD8<sup>+</sup> T-cell-deficient chickens: Occurrence of double negative T-cell tumour Phenotype analysis of lymphoid cells in Marek\\'s disease of CD4<sup>+</sup> or CD8<sup>+</sup> T-cell-deficient chickens: Occurrence of double negative T-cell tumour Avian Pathology, 26, 3, 525-534 Avian Pathology, 26, 3, 525-534 Avian Pathology, 26, 3, 525-534 1997 Refereed English Disclose to all
Y. Wada; H. Kubota; M. Maeda; M. Taniwaki; M. Hattori; S. Imamura; K. Iwai; N. Minato Y. Wada; H. Kubota; M. Maeda; M. Taniwaki; M. Hattori; S. Imamura; K. Iwai; N. Minato Y. Wada; H. Kubota; M. Maeda; M. Taniwaki; M. Hattori; S. Imamura; K. Iwai; N. Minato Mitogen-inducible SIPA1 is mapped to the conserved syntenic groups of chromosome 19 in mouse and chromosome 11q13.3 Centromeric to BCL1 in human Mitogen-inducible SIPA1 is mapped to the conserved syntenic groups of chromosome 19 in mouse and chromosome 11q13.3 Centromeric to BCL1 in human Mitogen-inducible SIPA1 is mapped to the conserved syntenic groups of chromosome 19 in mouse and chromosome 11q13.3 Centromeric to BCL1 in human Genomics, 39, 1, 66-73 Genomics, 39, 1, 66-73 Genomics, 39, 1, 66-73 1997 Refereed English Disclose to all
T. Morimura; K. Ohashi; Y. Kon; M. Hattori; C. Sugimoto; H. Onuma T. Morimura; K. Ohashi; Y. Kon; M. Hattori; C. Sugimoto; H. Onuma T. Morimura; K. Ohashi; Y. Kon; M. Hattori; C. Sugimoto; H. Onuma Apoptosis in peripheral CD4<sup>+</sup> T cells and thymocytes by Marek\\'s disease virus-infection Apoptosis in peripheral CD4<sup>+</sup> T cells and thymocytes by Marek\\'s disease virus-infection Apoptosis in peripheral CD4<sup>+</sup> T cells and thymocytes by Marek\\'s disease virus-infection Leukemia, 11, SUPPL. 3, 206-208 Leukemia, 11, SUPPL. 3, 206-208 Leukemia, 11, SUPPL. 3, 206-208 1997 Refereed English Disclose to all
H. Yamamoto; M. Hattori; K. Ohashi; C. Sugimoto; M. Onuma H. Yamamoto; M. Hattori; K. Ohashi; C. Sugimoto; M. Onuma H. Yamamoto; M. Hattori; K. Ohashi; C. Sugimoto; M. Onuma Characterization of extrathymic T cells of chickens Characterization of extrathymic T cells of chickens Characterization of extrathymic T cells of chickens Veterinary Immunology and Immunopathology, 49, 4, 375-386 Veterinary Immunology and Immunopathology, 49, 4, 375-386 Veterinary Immunology and Immunopathology, 49, 4, 375-386 1996 Refereed English Disclose to all
T. Morimura; K. Ohashi; Y. Kon; M. Hattori; C. Sugimoto; M. Onuma T. Morimura; K. Ohashi; Y. Kon; M. Hattori; C. Sugimoto; M. Onuma T. Morimura; K. Ohashi; Y. Kon; M. Hattori; C. Sugimoto; M. Onuma Apoptosis and CD8-down-regulation in the thymus of chickens infected with Marek\\'s disease virus Apoptosis and CD8-down-regulation in the thymus of chickens infected with Marek\\'s disease virus Apoptosis and CD8-down-regulation in the thymus of chickens infected with Marek\\'s disease virus Archives of Virology, 141, 11, 2243-2249 Archives of Virology, 141, 11, 2243-2249 Archives of Virology, 141, 11, 2243-2249 1996 Refereed English Disclose to all
T. Matsuba; C. Sugimoto; M. Hattori; Y. Sako; K. Fujisaki; M. Onuma T. Matsuba; C. Sugimoto; M. Hattori; Y. Sako; K. Fujisaki; M. Onuma T. Matsuba; C. Sugimoto; M. Hattori; Y. Sako; K. Fujisaki; M. Onuma Expression of a 32 kilodalton Theileria sergenti piroplasm surface protein by recombinant baculoviruses Expression of a 32 kilodalton Theileria sergenti piroplasm surface protein by recombinant baculoviruses Expression of a 32 kilodalton Theileria sergenti piroplasm surface protein by recombinant baculoviruses International Journal for Parasitology, 25, 8, 939-943 International Journal for Parasitology, 25, 8, 939-943 International Journal for Parasitology, 25, 8, 939-943 1995 Refereed English Disclose to all
T. Morimura; M. Hattori; K. Ohashi; C. Sugimoto; M. Onuma T. Morimura; M. Hattori; K. Ohashi; C. Sugimoto; M. Onuma T. Morimura; M. Hattori; K. Ohashi; C. Sugimoto; M. Onuma Immunomodulation of peripheral T cells in chickens infected with Marek\\'s disease virus: Involvement in immunosuppression Immunomodulation of peripheral T cells in chickens infected with Marek\\'s disease virus: Involvement in immunosuppression Immunomodulation of peripheral T cells in chickens infected with Marek\\'s disease virus: Involvement in immunosuppression Journal of General Virology, 76, 12, 2979-2985 Journal of General Virology, 76, 12, 2979-2985 Journal of General Virology, 76, 12, 2979-2985 1995 Refereed English Disclose to all
M. Hattori; N. Tsukamoto; M.S.A. Nur-E-Kamal; B. Rubinfeld; K. Iwai; H. Kubota; H. Maruta; N. Minato M. Hattori; N. Tsukamoto; M.S.A. Nur-E-Kamal; B. Rubinfeld; K. Iwai; H. Kubota; H. Maruta; N. Minato M. Hattori; N. Tsukamoto; M.S.A. Nur-E-Kamal; B. Rubinfeld; K. Iwai; H. Kubota; H. Maruta; N. Minato Molecular cloning of a novel mitogen-inducible nuclear protein with a Ran GTPase-activating domain that affects cell cycle progression Molecular cloning of a novel mitogen-inducible nuclear protein with a Ran GTPase-activating domain that affects cell cycle progression Molecular cloning of a novel mitogen-inducible nuclear protein with a Ran GTPase-activating domain that affects cell cycle progression Molecular and Cellular Biology, 15, 1, 552-560 Molecular and Cellular Biology, 15, 1, 552-560 Molecular and Cellular Biology, 15, 1, 552-560 1995 Refereed English Disclose to all
H. Yamamoto; M. Hattori; K. Ohashi; C. Sugimoto; M. Onuma H. Yamamoto; M. Hattori; K. Ohashi; C. Sugimoto; M. Onuma H. Yamamoto; M. Hattori; K. Ohashi; C. Sugimoto; M. Onuma Kinetic analysis of T cells and antibody production in chickens infected with Marek\\'s disease virus. Kinetic analysis of T cells and antibody production in chickens infected with Marek\\'s disease virus. Kinetic analysis of T cells and antibody production in chickens infected with Marek\\'s disease virus. The Journal of veterinary medical science / the Japanese Society of Veterinary Science, 57, 5, 945-946 The Journal of veterinary medical science / the Japanese Society of Veterinary Science, 57, 5, 945-946 The Journal of veterinary medical science / the Japanese Society of Veterinary Science, 57, 5, 945-946 1995 Refereed English Disclose to all
H. Kubota; M. Sato; Y. Ogawa; K. Iwai; M. Hattori; T. Yoshida; N. Minato H. Kubota; M. Sato; Y. Ogawa; K. Iwai; M. Hattori; T. Yoshida; N. Minato H. Kubota; M. Sato; Y. Ogawa; K. Iwai; M. Hattori; T. Yoshida; N. Minato Involvement of 4F2 antigen expressed on the MHC-negative target cells in the recognition of murine CD3<sup>+</sup>CD4<sup>-</sup>CD8<sup>-</sup> αβ (V(α)4/V(β)2) T cells Involvement of 4F2 antigen expressed on the MHC-negative target cells in the recognition of murine CD3<sup>+</sup>CD4<sup>-</sup>CD8<sup>-</sup> αβ (V(α)4/V(β)2) T cells Involvement of 4F2 antigen expressed on the MHC-negative target cells in the recognition of murine CD3<sup>+</sup>CD4<sup>-</sup>CD8<sup>-</sup> αβ (V(α)4/V(β)2) T cells International Immunology, 6, 9, 1323-1331 International Immunology, 6, 9, 1323-1331 International Immunology, 6, 9, 1323-1331 1994 Refereed English Disclose to all
T. Matsuba; H. Kubota; M. Tanaka; M. Hattori; M. Murata; C. Sugimto; M. Onuma T. Matsuba; H. Kubota; M. Tanaka; M. Hattori; M. Murata; C. Sugimto; M. Onuma T. Matsuba; H. Kubota; M. Tanaka; M. Hattori; M. Murata; C. Sugimto; M. Onuma Analysis of mixed parasite populations of Theileria sergenti using cDNA probes encoding a major piroplasm surface protein Analysis of mixed parasite populations of Theileria sergenti using cDNA probes encoding a major piroplasm surface protein Analysis of mixed parasite populations of Theileria sergenti using cDNA probes encoding a major piroplasm surface protein Parasitology, 107, 4, 369-377 Parasitology, 107, 4, 369-377 Parasitology, 107, 4, 369-377 1993 Refereed English Disclose to all
W.Z. Zhuang; M. Hattori; M. Onuma; H. Kodama W.Z. Zhuang; M. Hattori; M. Onuma; H. Kodama W.Z. Zhuang; M. Hattori; M. Onuma; H. Kodama Sensitive method for the detection of antibodies to infectious hematopoietic necrosis virus. Sensitive method for the detection of antibodies to infectious hematopoietic necrosis virus. Sensitive method for the detection of antibodies to infectious hematopoietic necrosis virus. The Journal of veterinary medical science / the Japanese Society of Veterinary Science, 54, 2, 371-373 The Journal of veterinary medical science / the Japanese Society of Veterinary Science, 54, 2, 371-373 The Journal of veterinary medical science / the Japanese Society of Veterinary Science, 54, 2, 371-373 1992 Refereed English Disclose to all
H. Kubota; H. Okazaki; M. Onuma; S. Kano; M. Hattori; N. Minato H. Kubota; H. Okazaki; M. Onuma; S. Kano; M. Hattori; N. Minato H. Kubota; H. Okazaki; M. Onuma; S. Kano; M. Hattori; N. Minato CD3<sup>+</sup>4<sup>-</sup>8<sup>-</sup> αβ T cell population with biased T cell receptor v gene usage: Presence in bone marrow and possible involvement of IL-3 for their extrathymic development CD3<sup>+</sup>4<sup>-</sup>8<sup>-</sup> αβ T cell population with biased T cell receptor v gene usage: Presence in bone marrow and possible involvement of IL-3 for their extrathymic development CD3<sup>+</sup>4<sup>-</sup>8<sup>-</sup> αβ T cell population with biased T cell receptor v gene usage: Presence in bone marrow and possible involvement of IL-3 for their extrathymic development Journal of Immunology, 149, 4, 1143-1150 Journal of Immunology, 149, 4, 1143-1150 Journal of Immunology, 149, 4, 1143-1150 1992 Refereed English Disclose to all
M. Niikara; Y. Matsuura; M. Hattori; M. Onuma; T. Mikami M. Niikara; Y. Matsuura; M. Hattori; M. Onuma; T. Mikami M. Niikara; Y. Matsuura; M. Hattori; M. Onuma; T. Mikami Expression of the A antigen (gp57-65) of Marek\\'s disease virus by a recombinant baculovirus Expression of the A antigen (gp57-65) of Marek\\'s disease virus by a recombinant baculovirus Expression of the A antigen (gp57-65) of Marek\\'s disease virus by a recombinant baculovirus Journal of General Virology, 72, 5, 1099-1104 Journal of General Virology, 72, 5, 1099-1104 Journal of General Virology, 72, 5, 1099-1104 1991 Refereed English Disclose to all
Y. Ogawa; H. Okazaki; T. Sudo; N. Ohno; M. Itoh; M. Hattori; M. Iizuka; N. Minato Y. Ogawa; H. Okazaki; T. Sudo; N. Ohno; M. Itoh; M. Hattori; M. Iizuka; N. Minato Y. Ogawa; H. Okazaki; T. Sudo; N. Ohno; M. Itoh; M. Hattori; M. Iizuka; N. Minato High-molecular-weight Ly-5 isoforms expressed on T cells: Activation-dependent expression High-molecular-weight Ly-5 isoforms expressed on T cells: Activation-dependent expression High-molecular-weight Ly-5 isoforms expressed on T cells: Activation-dependent expression International Immunology, 3, 1, 39-47 International Immunology, 3, 1, 39-47 International Immunology, 3, 1, 39-47 1991 Refereed English Disclose to all
N. Masahiro; M. Yoshiharu; H. Masakazu; O. Misao; M. Takeshi N. Masahiro; M. Yoshiharu; H. Masakazu; O. Misao; M. Takeshi N. Masahiro; M. Yoshiharu; H. Masakazu; O. Misao; M. Takeshi Characterization of haemagglutinin-neuraminidase glycoprotein of Newcastle disease virus expressed by a recombinant baculovirus Characterization of haemagglutinin-neuraminidase glycoprotein of Newcastle disease virus expressed by a recombinant baculovirus Characterization of haemagglutinin-neuraminidase glycoprotein of Newcastle disease virus expressed by a recombinant baculovirus Virus Research, 20, 1, 31-43 Virus Research, 20, 1, 31-43 Virus Research, 20, 1, 31-43 1991 Refereed English Disclose to all
R. Sawada; K. Ohashi; H. Anaguchi; H. Okazaki; M. Hattori; N. Minato; M. Naruto R. Sawada; K. Ohashi; H. Anaguchi; H. Okazaki; M. Hattori; N. Minato; M. Naruto R. Sawada; K. Ohashi; H. Anaguchi; H. Okazaki; M. Hattori; N. Minato; M. Naruto Isolation and expression of the full-length cDNA encoding CD59 antigen of human lymphocytes Isolation and expression of the full-length cDNA encoding CD59 antigen of human lymphocytes Isolation and expression of the full-length cDNA encoding CD59 antigen of human lymphocytes DNA and Cell Biology, 9, 3, 213-220 DNA and Cell Biology, 9, 3, 213-220 DNA and Cell Biology, 9, 3, 213-220 1990 Refereed English Disclose to all
T. Kondo; M. Hattori; H. Kodama; M. Onuma; T. Mikami T. Kondo; M. Hattori; H. Kodama; M. Onuma; T. Mikami T. Kondo; M. Hattori; H. Kodama; M. Onuma; T. Mikami Characterization of two monoclonal antibodies which recognize different subpopulations of chicken T lymphocytes. Characterization of two monoclonal antibodies which recognize different subpopulations of chicken T lymphocytes. Characterization of two monoclonal antibodies which recognize different subpopulations of chicken T lymphocytes. Japanese Journal of Veterinary Research, 38, 1, 11-17 Japanese Journal of Veterinary Research, 38, 1, 11-17 Japanese Journal of Veterinary Research, 38, 1, 11-17 1990 Refereed English Disclose to all
H. Kubota; H. Okazaki; M. Onuma; S. Kano; M. Hattori; N. Minato H. Kubota; H. Okazaki; M. Onuma; S. Kano; M. Hattori; N. Minato H. Kubota; H. Okazaki; M. Onuma; S. Kano; M. Hattori; N. Minato Identification and gene cloning of a new phosphatidylinositol-linked antigen expressed on mature lymphocytes: Down-regulation by lymphocyte activation Identification and gene cloning of a new phosphatidylinositol-linked antigen expressed on mature lymphocytes: Down-regulation by lymphocyte activation Identification and gene cloning of a new phosphatidylinositol-linked antigen expressed on mature lymphocytes: Down-regulation by lymphocyte activation Journal of Immunology, 145, 11, 3924-3931 Journal of Immunology, 145, 11, 3924-3931 Journal of Immunology, 145, 11, 3924-3931 1990 Refereed English Disclose to all
M. Hattori; H. Okazaki; Y. Ishida; M. Onuma; S. Kano; T. Honjo; N. Minato M. Hattori; H. Okazaki; Y. Ishida; M. Onuma; S. Kano; T. Honjo; N. Minato M. Hattori; H. Okazaki; Y. Ishida; M. Onuma; S. Kano; T. Honjo; N. Minato Expression of murine IL-2 receptor β-chain on thymic and splenic lymphocyte subpopulations as revealed by the IL-2-induced proliferative response in human IL-2 receptor α-chain transgenic mice Expression of murine IL-2 receptor β-chain on thymic and splenic lymphocyte subpopulations as revealed by the IL-2-induced proliferative response in human IL-2 receptor α-chain transgenic mice Expression of murine IL-2 receptor β-chain on thymic and splenic lymphocyte subpopulations as revealed by the IL-2-induced proliferative response in human IL-2 receptor α-chain transgenic mice Journal of Immunology, 144, 10, 3809-3815 Journal of Immunology, 144, 10, 3809-3815 Journal of Immunology, 144, 10, 3809-3815 1990 Refereed English Disclose to all
T. Kondo; M. Hattori; H. Kodama; M. Onuma; T. Mikami T. Kondo; M. Hattori; H. Kodama; M. Onuma; T. Mikami T. Kondo; M. Hattori; H. Kodama; M. Onuma; T. Mikami Production and characterization of monoclonal antibodies against chicken lymphocyte surface antigens. Production and characterization of monoclonal antibodies against chicken lymphocyte surface antigens. Production and characterization of monoclonal antibodies against chicken lymphocyte surface antigens. Nippon juigaku zasshi. The Japanese journal of veterinary science, 52, 1, 97-103 Nippon juigaku zasshi. The Japanese journal of veterinary science, 52, 1, 97-103 Nippon juigaku zasshi. The Japanese journal of veterinary science, 52, 1, 97-103 1990 Refereed English Disclose to all
Y. Ishida; M. Nishi; O. Taguchi; K. Inaba; M. Hattori; N. Minato; M. Kawaichi; T. Honjo Y. Ishida; M. Nishi; O. Taguchi; K. Inaba; M. Hattori; N. Minato; M. Kawaichi; T. Honjo Y. Ishida; M. Nishi; O. Taguchi; K. Inaba; M. Hattori; N. Minato; M. Kawaichi; T. Honjo Expansion of natural killer cells but not T cells in human interleukin 2/interleukin 2 receptor (Tac) transgenic mice Expansion of natural killer cells but not T cells in human interleukin 2/interleukin 2 receptor (Tac) transgenic mice Expansion of natural killer cells but not T cells in human interleukin 2/interleukin 2 receptor (Tac) transgenic mice Journal of Experimental Medicine, 170, 4, 1103-1115 Journal of Experimental Medicine, 170, 4, 1103-1115 Journal of Experimental Medicine, 170, 4, 1103-1115 1989 Refereed English Disclose to all
R. Sawada; K. Ohashi; K. Okano; M. Hattori; N. Minato; M. Naruto R. Sawada; K. Ohashi; K. Okano; M. Hattori; N. Minato; M. Naruto R. Sawada; K. Ohashi; K. Okano; M. Hattori; N. Minato; M. Naruto Complementary DNA sequence and deduced peptide sequence for CD59/MEM-43 antigen, the human homologue of murine lymphocyte antigen Ly-6C Complementary DNA sequence and deduced peptide sequence for CD59/MEM-43 antigen, the human homologue of murine lymphocyte antigen Ly-6C Complementary DNA sequence and deduced peptide sequence for CD59/MEM-43 antigen, the human homologue of murine lymphocyte antigen Ly-6C Nucleic Acids Research, 17, 16, 6728- Nucleic Acids Research, 17, 16, 6728- Nucleic Acids Research, 17, 16, 6728- 1989 Refereed English Disclose to all
M. Hattori; T. Sudo; H. Izawa; S. Kano; N. Minato M. Hattori; T. Sudo; H. Izawa; S. Kano; N. Minato M. Hattori; T. Sudo; H. Izawa; S. Kano; N. Minato Developmental regulation of the extrathymic differentiation potential of the progenitor cells for T cell lineage Developmental regulation of the extrathymic differentiation potential of the progenitor cells for T cell lineage Developmental regulation of the extrathymic differentiation potential of the progenitor cells for T cell lineage International Immunology, 1, 2, 151-159 International Immunology, 1, 2, 151-159 International Immunology, 1, 2, 151-159 1989 Refereed English Disclose to all
H. Okazaki; M. Ito; T. Sudo; M. Hattori; S. Kano; Y. Katsura; N. Minato H. Okazaki; M. Ito; T. Sudo; M. Hattori; S. Kano; Y. Katsura; N. Minato H. Okazaki; M. Ito; T. Sudo; M. Hattori; S. Kano; Y. Katsura; N. Minato IL-7 promotes thymocyte proliferation and maintains immunocompetent thymocytes bearing αβ or γδ T-cell receptors in vitro: Synergism with IL-2 IL-7 promotes thymocyte proliferation and maintains immunocompetent thymocytes bearing αβ or γδ T-cell receptors in vitro: Synergism with IL-2 IL-7 promotes thymocyte proliferation and maintains immunocompetent thymocytes bearing αβ or γδ T-cell receptors in vitro: Synergism with IL-2 Journal of Immunology, 143, 9, 2917-2922 Journal of Immunology, 143, 9, 2917-2922 Journal of Immunology, 143, 9, 2917-2922 1989 Refereed English Disclose to all
N. Minato; M. Hattori; T. Sudo; S. Kano; Y. Miura; J. Suda; T. Suda N. Minato; M. Hattori; T. Sudo; S. Kano; Y. Miura; J. Suda; T. Suda N. Minato; M. Hattori; T. Sudo; S. Kano; Y. Miura; J. Suda; T. Suda Differentiation in vitro of T3<sup>+</sup> large granular lymphocytes with characteristic cytotoxic activity from an isolated hematopoietic progenitor colony Differentiation in vitro of T3<sup>+</sup> large granular lymphocytes with characteristic cytotoxic activity from an isolated hematopoietic progenitor colony Differentiation in vitro of T3<sup>+</sup> large granular lymphocytes with characteristic cytotoxic activity from an isolated hematopoietic progenitor colony Journal of Experimental Medicine, 167, 3, 762-776 Journal of Experimental Medicine, 167, 3, 762-776 Journal of Experimental Medicine, 167, 3, 762-776 1988 Refereed English Disclose to all
M. Hattori; T. Udo; M. Iizuka; S. Kobayashi; S. Nishio; S. Kano; N. Minato M. Hattori; T. Udo; M. Iizuka; S. Kobayashi; S. Nishio; S. Kano; N. Minato M. Hattori; T. Udo; M. Iizuka; S. Kobayashi; S. Nishio; S. Kano; N. Minato Generation of continuous large granular lymphocyte lines by interleukin 2 from the spleen cells of mice infected with Moloney leukemia virus. Involvement of interleukin 3 Generation of continuous large granular lymphocyte lines by interleukin 2 from the spleen cells of mice infected with Moloney leukemia virus. Involvement of interleukin 3 Generation of continuous large granular lymphocyte lines by interleukin 2 from the spleen cells of mice infected with Moloney leukemia virus. Involvement of interleukin 3 Journal of Experimental Medicine, 166, 4, 833-849 Journal of Experimental Medicine, 166, 4, 833-849 Journal of Experimental Medicine, 166, 4, 833-849 1987 Refereed English Disclose to all
K. Ikuta; M. Hattori; K. Wake; S. Kano; T. Honjo; J. Yodoi; N. Minato K. Ikuta; M. Hattori; K. Wake; S. Kano; T. Honjo; J. Yodoi; N. Minato K. Ikuta; M. Hattori; K. Wake; S. Kano; T. Honjo; J. Yodoi; N. Minato Expression and rearrangement of the α, β, and γ chain genes of the T cell receptor in cloned murine large granular lymphocyte lines Expression and rearrangement of the α, β, and γ chain genes of the T cell receptor in cloned murine large granular lymphocyte lines Expression and rearrangement of the α, β, and γ chain genes of the T cell receptor in cloned murine large granular lymphocyte lines Journal of Experimental Medicine, 164, 2, 428-442 Journal of Experimental Medicine, 164, 2, 428-442 Journal of Experimental Medicine, 164, 2, 428-442 1986 Refereed English Disclose to all

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Title language:
Misc
Author Author(Japanese) Author(English) Title Title(Japanese) Title(English) Bibliography Bibliography(Japanese) Bibliography(English) Publication date Refereed paper Language Publishing type Disclose
K. Shimatani; Y. Nakashima; M. Hattori; Y. Hamazaki; N. Minato K. Shimatani; Y. Nakashima; M. Hattori; Y. Hamazaki; N. Minato K. Shimatani; Y. Nakashima; M. Hattori; Y. Hamazaki; N. Minato PD-1<sup>+</sup> memory phenotype CD4<sup>+</sup> T cells expressing C/EBPα underlie T cell immunodepression in senescence and leukemia PD-1<sup>+</sup> memory phenotype CD4<sup>+</sup> T cells expressing C/EBPα underlie T cell immunodepression in senescence and leukemia PD-1<sup>+</sup> memory phenotype CD4<sup>+</sup> T cells expressing C/EBPα underlie T cell immunodepression in senescence and leukemia Proceedings of the National Academy of Sciences of the United States of America, 106, 37, 15807-15812 Proceedings of the National Academy of Sciences of the United States of America, 106, 37, 15807-15812 Proceedings of the National Academy of Sciences of the United States of America, 106, 37, 15807-15812 2009/09/15 Refereed English Disclose to all
D. Ishida; H. Yang; K. Masuda; K. Uesugi; H. Kawamoto; M. Hattori; N. Minato D. Ishida; H. Yang; K. Masuda; K. Uesugi; H. Kawamoto; M. Hattori; N. Minato D. Ishida; H. Yang; K. Masuda; K. Uesugi; H. Kawamoto; M. Hattori; N. Minato Antigen-driven T cell anergy and defective memory T cell response via deregulated Rap1 activation in SPA-1-deficient mice Antigen-driven T cell anergy and defective memory T cell response via deregulated Rap1 activation in SPA-1-deficient mice Antigen-driven T cell anergy and defective memory T cell response via deregulated Rap1 activation in SPA-1-deficient mice Proceedings of the National Academy of Sciences of the United States of America, 100, 19, 10919-10924 Proceedings of the National Academy of Sciences of the United States of America, 100, 19, 10919-10924 Proceedings of the National Academy of Sciences of the United States of America, 100, 19, 10919-10924 2003 Refereed English Disclose to all
Title language:
Conference Activities & Talks
Title Title(Japanese) Title(English) Conference Conference(Japanese) Conference(English) Promotor Promotor(Japanese) Promotor(English) Date Language Assortment Disclose
老化関連T細胞の誘導メカニズムとその制御[Invited] 老化関連T細胞の誘導メカニズムとその制御 [Invited] 日本炎症・再生医学会 日本炎症・再生医学会 2017/07/18 Japanese Oral presentation(invited, special) Disclose to all
Title language:
Patents
Inventor(s) Inventor(s) (Japanese) Inventor(s) (English) Title Title(Japanese) Title(English) Stage Patent number Date Disclose
服部雅一,井上 浄,赤澤悠子 服部雅一,井上 浄,赤澤悠子 抗原特異的モノクローナル抗体産生ハイブリドーマの作成方法及び抗原特異的モノクローナル抗体の製造作成 抗原特異的モノクローナル抗体産生ハイブリドーマの作成方法及び抗原特異的モノクローナル抗体の製造作成 特許登録 特許5996437 2016/09/02 Disclose to all
宮下武憲,森望,西望,安達栄治郎,松下治,服部雅一,伊藤周平,坂本恵子 宮下武憲,森望,西望,安達栄治郎,松下治,服部雅一,伊藤周平,坂本恵子 粘膜,上皮および鼓膜の少なくとも一つの再生材および再生評価方法 粘膜,上皮および鼓膜の少なくとも一つの再生材および再生評価方法 特許出願 特願2010-110694 2010/05/12 Disclose to all
SPA-1蛋白質及びそれをコードする遺伝子 SPA-1蛋白質及びそれをコードする遺伝子 特許登録 特許3683000 Disclose to all
Title language:
External funds: competitive funds and Grants-in-Aid for Scientific Research (Kakenhi)
Type Position Title(Japanese) Title(English) Period
基盤研究(B) Representative がん・病原微生物によるT細胞機能抑制の分子メカニズム解明とその制御  -
1. 挑戦的萌芽研究 Representative 「人工リンパ節技術を用いた新規アジュバントの開発と高機能型抗体の作製」 -
2  基盤研究(B) Representative 「がん・病原微生物によるT細胞機能抑制の分子メカニズム解明とその制御」 -
3. 基盤研究(B) Assignment 「コラーゲン細線維の積層と細胞成長因子の固相化による人工組織の実用化に関する研究」 -
4. 基盤研究(A) Assignment 「比較ゲノム解析によるタイレリア原虫病原性進化の解明」 -
基盤研究(C) Representative 免疫老化の分子メカニズムの解明とワクチン開発への応用 (平成26年度分) 2014/04/01-2015/03/31
基盤研究(C) Representative 免疫老化の分子メカニズムの解明とワクチン開発への応用 (平成27年度分) 2015/04/01-2016/03/31
基盤研究(C) Representative 免疫老化の分子メカニズムの解明とワクチン開発への応用 (平成28年度分) 2016/04/01-2017/03/31
基盤研究(B) Representative 老化関連T細胞誘導メカニズムの解明と人為的制御 (平成29年度分) 2017/04/01-2018/03/31
挑戦的研究(萌芽) Representative メモリーT細胞を直接標的とした新規アジュバントの創出 (平成30年度分) 2018/04/01-2019/03/31