堀田 秋津

Last Update: 2018/06/06 19:50:13

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Name(Kanji/Kana/Abecedarium Latinum)
堀田 秋津/ホッタ アキツ/Hotta, Akitsu
Primary Affiliation(Org1/Job title)
iPS細胞研究所/Program-Specific Research Center Senior Lecturer/Program-Specific Research Center Junior Associate Professor
Concurrent Affiliation
Org1 Job title
Center for iPS Cell Research and Application (CiRA) Program-Specific Research Center Senior Lecturer/Program-Specific Research Center Junior Associate Professor
Center for iPS Cell Research and Application (CiRA) Program-Specific Research Center Senior Lecturer/Program-Specific Research Center Junior Associate Professor
Contact Address
Type Address(Japanese) Address(English)
Office 京都市 左京区 聖護院川原町53 iPS細胞研究所 CiRA, 53 Seigoin Kawahara-cho, Sakyo-ku, Kyoto, JAPAN
Phone
Type Number
Office 075-366-7056
E-mail Address
E-mail address
akitsu.hotta @ cira.kyoto-u.ac.jp
Academic Organizations You are Affiliated to in Japan
Organization name(Japanese) Organization name(English)
日本分子生物学会 The Molecular Biology Society of Japan
日本再生医療学会 The Japanise Society for Regenerative Medicine
日本遺伝子治療学会 Japan Society of Gene Therapy
Academic Organizations Overaseas You are Affiliated to
Organization name Country
ISSCR (International Society for Stem Cell Research) USA
ASGCT (American Society of Gene & Cell Therapy) USA
Academic Degree
Field(Japanese) Field(English) University(Japanese) University(English) Method
修士(工学) 名古屋大学
博士(工学) 名古屋大学
Graduate School
University(Japanese) University(English) Faculty(Japanese) Faculty(English) Major(Japanese) Major(English) Degree
名古屋大学 Nagoya University 大学院工学研究科博士課程後期課程生物機能工学専攻 修了
名古屋大学 Nagoya University 大学院工学研究科博士課程前期課程生物機能工学専攻 修了
Undergraduate School / Major(s)
University(Japanese) University(English) Faculty(Japanese) Faculty(English) Major(s)(Japanese) Major(s)(English) Degree
名古屋大学 Nagoya University 工学部化学・生物工学科 卒業
High School
Highschool Kana
名古屋大学教育学部附属高等学校 ナゴヤダイガク キョウイクガクブフゾク コウトウガッコウ
Work Experience
Period Organization(Japanese) Organization(English) Job title(Japanese) Job title(English)
2006/04/01-2010/02/28 トロント小児病院 Hospital for Sick Children 博士研究員 Postdoctoral Research Fellow
2008/06/01-2010/02/28 オンタリオ ヒトiPS細胞研究部門 Ontario Human iPS Cell Facility 研究員 Research Fellow
2010/10/01-2014/03/31 JST戦略的創造研究推進事業 Japan Science and Technology Agency (JST) さきがけ研究員 PRESTO Researcher
Personal Website(s) (URL(s))
URL
http://www.cira.kyoto-u.ac.jp/hotta/
ORCID ID
https://orcid.org/0000-0002-2619-7441
researchmap URL
https://researchmap.jp/read0144114
Research Topics
(Japanese)
iPS細胞の遺伝子工学と遺伝子治療
(English)
Gene Engineering and Gene Therapy of iPS cells
Overview of the research
(Japanese)
iPS細胞は患者本人から低侵襲で樹立することができ、分化多能性を保ったまま好きなだけ増幅することができるため、病態解明や薬剤のスクリーニング、さらには細胞移植による再生医療への応用が期待されています。しかし、血友病や筋ジストロフィーなど先天的な遺伝子異常で起こる疾患については、患者からiPS細胞を樹立しても遺伝子異常を引き継いでいるため、この遺伝子異常を何らかの方法で治す必要があります。当研究部門では、ウイルスベクターやトランスポゾンベクターによる遺伝子導入ベクター開発や、CRISPR-Cas9システムを中心としたゲノム編集技術、エピジェネティック発現制御技術を駆使して、新しい"iPS細胞遺伝子治療"の実現に向けた研究に取り組んでいます。
(English)
iPS cell technology provides a way to isolate any cell type from a donor in a minimally invasive fashion. Two attractive features of iPS cells are that they can grow indefinitely on culture dish by keeping their pluripotency and be differentiated into any cell type. Thus, iPS cells have enormous potential for drug testing and future stem cell therapy. They also offer transplantation that is free of immune rejection and independent of donor supply. However, when iPS cells are derived from patients with congenital genetic disorders, such as hemophilia or muscular dystrophy, the genetic mutations must be repaired before transplantation. For this reason, our research group aims to develop novel iPS cell based therapies for genetic disorders using non-viral transposon-mediated gene delivery methods and genome editing technologies, such as the CRISPR-Cas9 system.
Fields of research (key words)
Key words(Japanese) Key words(English)
iPS細胞、遺伝子治療、エピジェネティック、ウイルスベクター iPS cells, Gene therapy, Epigenetics, Viral vector
Published Papers
Author Author(Japanese) Author(English) Title Title(Japanese) Title(English) Bibliography Bibliography(Japanese) Bibliography(English) Publication date Refereed paper Language Publishing type Disclose
Honda-Ozaki F, Terashima M, Niwa A, Saiki N, Kawasaki Y, Ito H, Hotta A, Nagahashi A, Igura K, Asaka I, Li HL, Yanagimachi M, Furukawa F, Kanazawa N, Saito MK Honda-Ozaki F, Terashima M, Niwa A, Saiki N, Kawasaki Y, Ito H, Hotta A, Nagahashi A, Igura K, Asaka I, Li HL, Yanagimachi M, Furukawa F, Kanazawa N, Saito MK Honda-Ozaki F, Terashima M, Niwa A, Saiki N, Kawasaki Y, Ito H, Hotta A, Nagahashi A, Igura K, Asaka I, Li HL, Yanagimachi M, Furukawa F, Kanazawa N, Saito MK Pluripotent Stem Cell Model of Nakajo-Nishimura Syndrome Untangles Proinflammatory Pathways Mediated by Oxidative Stress. Pluripotent Stem Cell Model of Nakajo-Nishimura Syndrome Untangles Proinflammatory Pathways Mediated by Oxidative Stress. Pluripotent Stem Cell Model of Nakajo-Nishimura Syndrome Untangles Proinflammatory Pathways Mediated by Oxidative Stress. Stem cell reports Stem cell reports Stem cell reports 2018/05 Refereed Disclose to all
Takashi Ikeda, Takafusa Hikichi, Hisashi Miura, Hirofumi Shibata, Kanae Mitsunaga, Yosuke Yamada, Knut Woltjen, Kei Miyamoto, Ichiro Hiratani, Yasuhiro Yamada, Akitsu Hotta, Takuya Yamamoto, Keisuke Okita, Shinji Masui Takashi Ikeda, Takafusa Hikichi, Hisashi Miura, Hirofumi Shibata, Kanae Mitsunaga, Yosuke Yamada, Knut Woltjen, Kei Miyamoto, Ichiro Hiratani, Yasuhiro Yamada, Akitsu Hotta, Takuya Yamamoto, Keisuke Okita, Shinji Masui Takashi Ikeda, Takafusa Hikichi, Hisashi Miura, Hirofumi Shibata, Kanae Mitsunaga, Yosuke Yamada, Knut Woltjen, Kei Miyamoto, Ichiro Hiratani, Yasuhiro Yamada, Akitsu Hotta, Takuya Yamamoto, Keisuke Okita, Shinji Masui Srf destabilizes cellular identity by suppressing cell-type-specific gene expression programs Srf destabilizes cellular identity by suppressing cell-type-specific gene expression programs Srf destabilizes cellular identity by suppressing cell-type-specific gene expression programs Nature Communications, 9, 1 Nature Communications, 9, 1 Nature Communications, 9, 1 2018/04 Refereed Disclose to all
Oshima K, Saiki N, Tanaka M, Imamura H, Niwa A, Tanimura A, Nagahashi A, Hirayama A, Okita K, Hotta A, Kitayama S, Osawa M, Kaneko S, Watanabe A, Saito MK Oshima K, Saiki N, Tanaka M, Imamura H, Niwa A, Tanimura A, Nagahashi A, Hirayama A, Okita K, Hotta A, Kitayama S, Osawa M, Kaneko S, Watanabe A, Saito MK Oshima K, Saiki N, Tanaka M, Imamura H, Niwa A, Tanimura A, Nagahashi A, Hirayama A, Okita K, Hotta A, Kitayama S, Osawa M, Kaneko S, Watanabe A, Saito MK Human AK2 links intracellular bioenergetic redistribution to the fate of hematopoietic progenitors. Human AK2 links intracellular bioenergetic redistribution to the fate of hematopoietic progenitors. Human AK2 links intracellular bioenergetic redistribution to the fate of hematopoietic progenitors. Biochemical and biophysical research communications Biochemical and biophysical research communications Biochemical and biophysical research communications 2018/03 Refereed Disclose to all
Kentaro Ishida, Huaigeng Xu, Noriko Sasakawa, Mandy Siu Yu Lung, Julia Alexandra Kudryashev, Peter Gee, Akitsu Hotta Kentaro Ishida, Huaigeng Xu, Noriko Sasakawa, Mandy Siu Yu Lung, Julia Alexandra Kudryashev, Peter Gee, Akitsu Hotta Kentaro Ishida, Huaigeng Xu, Noriko Sasakawa, Mandy Siu Yu Lung, Julia Alexandra Kudryashev, Peter Gee, Akitsu Hotta Site-specific randomization of the endogenous genome by a regulatable CRISPR-Cas9 piggyBac system in human cells Site-specific randomization of the endogenous genome by a regulatable CRISPR-Cas9 piggyBac system in human cells Site-specific randomization of the endogenous genome by a regulatable CRISPR-Cas9 piggyBac system in human cells Scientific Reports, 8, 1, 310 Scientific Reports, 8, 1, 310 Scientific Reports, 8, 1, 310 2018/01 Refereed English Research paper(scientific journal) Disclose to all
Takada S, Kambe N, Kawasaki Y, Niwa A, Honda-Ozaki F, Kobayashi K, Osawa M, Nagahashi A, Semi K, Hotta A, Asaka I, Yamada Y, Nishikomori R, Heike T, Saito MK Takada S, Kambe N, Kawasaki Y, Niwa A, Honda-Ozaki F, Kobayashi K, Osawa M, Nagahashi A, Semi K, Hotta A, Asaka I, Yamada Y, Nishikomori R, Heike T, Saito MK Takada S, Kambe N, Kawasaki Y, Niwa A, Honda-Ozaki F, Kobayashi K, Osawa M, Nagahashi A, Semi K, Hotta A, Asaka I, Yamada Y, Nishikomori R, Heike T, Saito MK Pluripotent stem cell models of Blau syndrome reveal an IFN-γ-dependent inflammatory response in macrophages. Pluripotent stem cell models of Blau syndrome reveal an IFN-γ-dependent inflammatory response in macrophages. Pluripotent stem cell models of Blau syndrome reveal an IFN-γ-dependent inflammatory response in macrophages. The Journal of allergy and clinical immunology The Journal of allergy and clinical immunology The Journal of allergy and clinical immunology 2018/01 Refereed Disclose to all
Yoji Kojima, Kotaro Sasaki, Shihori Yokobayashi, Yoshitake Sakai, Tomonori Nakamura, Yukihiro Yabuta, Fumio Nakaki, So Nagaoka, Knut Woltjen, Akitsu Hotta, Takuya Yamamoto, Mitinori Saitou Yoji Kojima, Kotaro Sasaki, Shihori Yokobayashi, Yoshitake Sakai, Tomonori Nakamura, Yukihiro Yabuta, Fumio Nakaki, So Nagaoka, Knut Woltjen, Akitsu Hotta, Takuya Yamamoto, Mitinori Saitou Yoji Kojima, Kotaro Sasaki, Shihori Yokobayashi, Yoshitake Sakai, Tomonori Nakamura, Yukihiro Yabuta, Fumio Nakaki, So Nagaoka, Knut Woltjen, Akitsu Hotta, Takuya Yamamoto, Mitinori Saitou Evolutionarily Distinctive Transcriptional and Signaling Programs Drive Human Germ Cell Lineage Specification from Pluripotent Stem Cells Evolutionarily Distinctive Transcriptional and Signaling Programs Drive Human Germ Cell Lineage Specification from Pluripotent Stem Cells Evolutionarily Distinctive Transcriptional and Signaling Programs Drive Human Germ Cell Lineage Specification from Pluripotent Stem Cells Cell Stem Cell, 21, 4, 517 Cell Stem Cell, 21, 4, 517 Cell Stem Cell, 21, 4, 517 2017/10 Refereed Disclose to all
Zhaoyi Chen, Wing Y. Chang, Alton Etheridge, Hilmar Strickfaden, Zhigang Jin, Gareth Palidwor, Ji-Hoon Cho, Kai Wang, Sarah Y. Kwon, Carole Dor{\'{e}}, Angela Raymond, Akitsu Hotta, James Ellis, Rita A. Kandel, F. Jeffrey Dilworth, Theodore J. Perkins, Michael J. Hendzel, David J. Galas, William L. Stanford Zhaoyi Chen, Wing Y. Chang, Alton Etheridge, Hilmar Strickfaden, Zhigang Jin, Gareth Palidwor, Ji-Hoon Cho, Kai Wang, Sarah Y. Kwon, Carole Dor{\'{e}}, Angela Raymond, Akitsu Hotta, James Ellis, Rita A. Kandel, F. Jeffrey Dilworth, Theodore J. Perkins, Michael J. Hendzel, David J. Galas, William L. Stanford Zhaoyi Chen, Wing Y. Chang, Alton Etheridge, Hilmar Strickfaden, Zhigang Jin, Gareth Palidwor, Ji-Hoon Cho, Kai Wang, Sarah Y. Kwon, Carole Dor{\'{e}}, Angela Raymond, Akitsu Hotta, James Ellis, Rita A. Kandel, F. Jeffrey Dilworth, Theodore J. Perkins, Michael J. Hendzel, David J. Galas, William L. Stanford Reprogramming progeria fibroblasts re-establishes a normal epigenetic landscape Reprogramming progeria fibroblasts re-establishes a normal epigenetic landscape Reprogramming progeria fibroblasts re-establishes a normal epigenetic landscape Aging Cell, 16, 4, 870 Aging Cell, 16, 4, 870 Aging Cell, 16, 4, 870 2017/06 Refereed Disclose to all
Moe Hirosawa, Yoshihiko Fujita, Callum~J.~C. Parr, Karin Hayashi, Shunnichi Kashida, Akitsu Hotta, Knut Woltjen, Hirohide Saito Moe Hirosawa, Yoshihiko Fujita, Callum~J.~C. Parr, Karin Hayashi, Shunnichi Kashida, Akitsu Hotta, Knut Woltjen, Hirohide Saito Moe Hirosawa, Yoshihiko Fujita, Callum~J.~C. Parr, Karin Hayashi, Shunnichi Kashida, Akitsu Hotta, Knut Woltjen, Hirohide Saito Cell-type-specific genome editing with a microRNA-responsive CRISPR–Cas9 switch Cell-type-specific genome editing with a microRNA-responsive CRISPR–Cas9 switch Cell-type-specific genome editing with a microRNA-responsive CRISPR–Cas9 switch Nucleic Acids Research, 45, 13, e118 Nucleic Acids Research, 45, 13, e118 Nucleic Acids Research, 45, 13, e118 2017/05 Refereed Disclose to all
Imamura K, Izumi Y, Watanabe A, Tsukita K, Woltjen K, Yamamoto T, Hotta A, Kondo T, Kitaoka S, Ohta A, Tanaka A, Watanabe D, Morita M, Takuma H, Inoue H Imamura K, Izumi Y, Watanabe A, Tsukita K, Woltjen K, Yamamoto T, Hotta A, Kondo T, Kitaoka S, Ohta A, Tanaka A, Watanabe D, Morita M, Takuma H, Inoue H Imamura K, Izumi Y, Watanabe A, Tsukita K, Woltjen K, Yamamoto T, Hotta A, Kondo T, Kitaoka S, Ohta A, Tanaka A, Watanabe D, Morita M, Takuma H, Inoue H The Src/c-Abl pathway is a potential therapeutic target in amyotrophic lateral sclerosis. The Src/c-Abl pathway is a potential therapeutic target in amyotrophic lateral sclerosis. The Src/c-Abl pathway is a potential therapeutic target in amyotrophic lateral sclerosis. Science translational medicine Science translational medicine Science translational medicine 2017/05 Refereed Disclose to all
Peter Gee, Huaigeng Xu, Akitsu Hotta Peter Gee, Huaigeng Xu, Akitsu Hotta Peter Gee, Huaigeng Xu, Akitsu Hotta Cellular Reprogramming, Genome Editing, and Alternative CRISPR Cas9 Technologies for Precise Gene Therapy of Duchenne Muscular Dystrophy Cellular Reprogramming, Genome Editing, and Alternative CRISPR Cas9 Technologies for Precise Gene Therapy of Duchenne Muscular Dystrophy Cellular Reprogramming, Genome Editing, and Alternative CRISPR Cas9 Technologies for Precise Gene Therapy of Duchenne Muscular Dystrophy Stem Cells International, 2017, 1 Stem Cells International, 2017, 1 Stem Cells International, 2017, 1 2017 Refereed Disclose to all
Choi IY, Lim H, Estrellas K, Mula J, Cohen TV, Zhang Y, Donnelly CJ, Richard JP, Kim YJ, Kim H, Kazuki Y, Oshimura M, Li HL, Hotta A, Rothstein J, Maragakis N, Wagner KR, Lee G Choi IY, Lim H, Estrellas K, Mula J, Cohen TV, Zhang Y, Donnelly CJ, Richard JP, Kim YJ, Kim H, Kazuki Y, Oshimura M, Li HL, Hotta A, Rothstein J, Maragakis N, Wagner KR, Lee G Choi IY, Lim H, Estrellas K, Mula J, Cohen TV, Zhang Y, Donnelly CJ, Richard JP, Kim YJ, Kim H, Kazuki Y, Oshimura M, Li HL, Hotta A, Rothstein J, Maragakis N, Wagner KR, Lee G Concordant but varied phenotypes among Duchenne muscular dystrophy patient-specific myoblasts derived using a human iPSC-based model. Concordant but varied phenotypes among Duchenne muscular dystrophy patient-specific myoblasts derived using a human iPSC-based model. Concordant but varied phenotypes among Duchenne muscular dystrophy patient-specific myoblasts derived using a human iPSC-based model. Cell Reports, 15, 10, 2301-2312 Cell Reports, 15, 10, 2301-2312 Cell Reports, 15, 10, 2301-2312 2016/06 Refereed English Research paper(scientific journal) Disclose to all
Li HL, Gee P, Ishida K, Hotta A Li HL, Gee P, Ishida K, Hotta A Li HL, Gee P, Ishida K, Hotta A Efficient genomic correction methods in human iPS cells using CRISPR-Cas9 system. Efficient genomic correction methods in human iPS cells using CRISPR-Cas9 system. Efficient genomic correction methods in human iPS cells using CRISPR-Cas9 system. Methods, 101, 27-35 Methods, 101, 27-35 Methods, 101, 27-35 2016/05 Refereed English Research paper(scientific journal) Disclose to all
Komura S, Semi K, Itakura F, Shibata H, Ohno T, Hotta A, Woltjen K, Yamamoto T, Akiyama H, Yamada Y Komura S, Semi K, Itakura F, Shibata H, Ohno T, Hotta A, Woltjen K, Yamamoto T, Akiyama H, Yamada Y Komura S, Semi K, Itakura F, Shibata H, Ohno T, Hotta A, Woltjen K, Yamamoto T, Akiyama H, Yamada Y An EWS-FLI1-induced osteosarcoma model unveiled a crucial role of impaired osteogenic differentiation on osteosarcoma development. An EWS-FLI1-induced osteosarcoma model unveiled a crucial role of impaired osteogenic differentiation on osteosarcoma development. An EWS-FLI1-induced osteosarcoma model unveiled a crucial role of impaired osteogenic differentiation on osteosarcoma development. Stem Cell Reports, 6, 4, 592-606 Stem Cell Reports, 6, 4, 592-606 Stem Cell Reports, 6, 4, 592-606 2016/04 Refereed English Research paper(scientific journal) Disclose to all
Morita Y, Andersen P, Hotta A, Tsukahara Y, Sasagawa N, Hayashida N, Koga C, Nishikawa M, Saga Y, Evans SM, Koshiba-Takeuchi K, Nishinakamura R, Yoshida Y, Kwon C, Takeuchi JK Morita Y, Andersen P, Hotta A, Tsukahara Y, Sasagawa N, Hayashida N, Koga C, Nishikawa M, Saga Y, Evans SM, Koshiba-Takeuchi K, Nishinakamura R, Yoshida Y, Kwon C, Takeuchi JK Morita Y, Andersen P, Hotta A, Tsukahara Y, Sasagawa N, Hayashida N, Koga C, Nishikawa M, Saga Y, Evans SM, Koshiba-Takeuchi K, Nishinakamura R, Yoshida Y, Kwon C, Takeuchi JK Sall1 transiently marks undifferentiated heart precursors and regulates their fate. Sall1 transiently marks undifferentiated heart precursors and regulates their fate. Sall1 transiently marks undifferentiated heart precursors and regulates their fate. Journal of Molecular and Cellular Cardiology, 92, 158-162 Journal of Molecular and Cellular Cardiology, 92, 158-162 Journal of Molecular and Cellular Cardiology, 92, 158-162 2016/03 Refereed English Research paper(scientific journal) Disclose to all
Ishida K, Gee P, Hotta A Ishida K, Gee P, Hotta A Ishida K, Gee P, Hotta A Minimizing off-target mutagenesis risks caused by programmable nucleases. Minimizing off-target mutagenesis risks caused by programmable nucleases. Minimizing off-target mutagenesis risks caused by programmable nucleases. International Journal of Molecular Sciences, 16, 10, 24771 International Journal of Molecular Sciences, 16, 10, 24771 International Journal of Molecular Sciences, 16, 10, 24771 2015/10 Refereed English Research paper(scientific journal) Disclose to all
Hotta A, Yamanaka S Hotta A, Yamanaka S Hotta A, Yamanaka S From genomics to gene therapy: induced pluripotent stem cells meet genome editing. From genomics to gene therapy: induced pluripotent stem cells meet genome editing. From genomics to gene therapy: induced pluripotent stem cells meet genome editing. Annual Review of Genetics, 49, 47-70 Annual Review of Genetics, 49, 47-70 Annual Review of Genetics, 49, 47-70 2015/09 Refereed English Research paper(scientific journal) Disclose to all
Ishikawa M, Ohnishi H, Skerleva D, Sakamoto T, Yamamoto N, Hotta A, Ito J, Nakagawa T Ishikawa M, Ohnishi H, Skerleva D, Sakamoto T, Yamamoto N, Hotta A, Ito J, Nakagawa T Ishikawa M, Ohnishi H, Skerleva D, Sakamoto T, Yamamoto N, Hotta A, Ito J, Nakagawa T Transplantation of neurons derived from human iPS cells cultured on collagen matrix into guinea-pig cochleae. Transplantation of neurons derived from human iPS cells cultured on collagen matrix into guinea-pig cochleae. Transplantation of neurons derived from human iPS cells cultured on collagen matrix into guinea-pig cochleae. Journal of Tissue Engineering and Regenerative Medicine Journal of Tissue Engineering and Regenerative Medicine Journal of Tissue Engineering and Regenerative Medicine 2015/07 Refereed English Research paper(scientific journal) Disclose to all
Iizuka H, Kagoya Y, Kataoka K, Yoshimi A, Miyauchi M, Taoka K, Kumano K, Yamamoto T, Hotta A, Arai S, Kurokawa M Iizuka H, Kagoya Y, Kataoka K, Yoshimi A, Miyauchi M, Taoka K, Kumano K, Yamamoto T, Hotta A, Arai S, Kurokawa M Iizuka H, Kagoya Y, Kataoka K, Yoshimi A, Miyauchi M, Taoka K, Kumano K, Yamamoto T, Hotta A, Arai S, Kurokawa M Targeted gene correction of RUNX1 in induced pluripotent stem cells derived from familial platelet disorder with propensity to myeloid malignancy restores normal megakaryopoiesis. Targeted gene correction of RUNX1 in induced pluripotent stem cells derived from familial platelet disorder with propensity to myeloid malignancy restores normal megakaryopoiesis. Targeted gene correction of RUNX1 in induced pluripotent stem cells derived from familial platelet disorder with propensity to myeloid malignancy restores normal megakaryopoiesis. Experimental Hematology, 43, 10, 849-857 Experimental Hematology, 43, 10, 849-857 Experimental Hematology, 43, 10, 849-857 2015/06 Refereed English Research paper(scientific journal) Disclose to all
堀田秋津, 石田賢太郎, 佐伯涼太 堀田秋津, 石田賢太郎, 佐伯涼太 疾患iPS細胞研究を加速する遺伝子改変技術の進歩 疾患iPS細胞研究を加速する遺伝子改変技術の進歩 病理と臨床, 33, 6, 622-626 病理と臨床, 33, 6, 622-626 , 33, 6, 622-626 2015/06 Japanese Research paper(scientific journal) Disclose to all
津下 到, 鈴木茂彦, 内藤素子, 堀田秋津, 井上治久 津下 到, 鈴木茂彦, 内藤素子, 堀田秋津, 井上治久 津下 到, 鈴木茂彦, 内藤素子, 堀田秋津, 井上治久 患者由来iPS細胞を用いた神経疾患研究 患者由来iPS細胞を用いた神経疾患研究 患者由来iPS細胞を用いた神経疾患研究 Journal of Clinical and Experimental Medicine, 252, 7, 824-828 医学のあゆみ, 252, 7, 824-828 Journal of Clinical and Experimental Medicine, 252, 7, 824-828 2015/02/14 Japanese Research paper(scientific journal) Disclose to all
堀田秋津 堀田秋津 堀田秋津 iPS細胞応用を加速するゲノム編集技術 iPS細胞応用を加速するゲノム編集技術 iPS細胞応用を加速するゲノム編集技術 Journal of Clinical and Experimental Medicine, 252, 2, 183-188 医学のあゆみ, 252, 2, 183-188 Journal of Clinical and Experimental Medicine, 252, 2, 183-188 2015/01/10 Japanese Research paper(scientific journal) Disclose to all
Li HL, Fujimoto N, Sasakawa N, Shirai S, Ohkame T, Sakuma T, Tanaka M, Amano N, Watanabe A, Sakurai H, Yamamoto T, Yamanaka S, Hotta A Li HL, Fujimoto N, Sasakawa N, Shirai S, Ohkame T, Sakuma T, Tanaka M, Amano N, Watanabe A, Sakurai H, Yamamoto T, Yamanaka S, Hotta A Li HL, Fujimoto N, Sasakawa N, Shirai S, Ohkame T, Sakuma T, Tanaka M, Amano N, Watanabe A, Sakurai H, Yamamoto T, Yamanaka S, Hotta A Precise correction of the dystrophin gene in duchenne muscular dystrophy patient induced pluripotent stem cells by TALEN and CRISPR-Cas9. Precise correction of the dystrophin gene in duchenne muscular dystrophy patient induced pluripotent stem cells by TALEN and CRISPR-Cas9. Precise correction of the dystrophin gene in duchenne muscular dystrophy patient induced pluripotent stem cells by TALEN and CRISPR-Cas9. Stem Cell Reports, 4, 1, 143-154 Stem Cell Reports, 4, 1, 143-154 Stem Cell Reports, 4, 1, 143-154 2015/01 Refereed English Research paper(scientific journal) Disclose to all
Rahmani W, Abbasi S, Hagner A, Raharjo E, Kumar R, Hotta A, Magness S, Metzger D, Biernaskie J Rahmani W, Abbasi S, Hagner A, Raharjo E, Kumar R, Hotta A, Magness S, Metzger D, Biernaskie J Rahmani W, Abbasi S, Hagner A, Raharjo E, Kumar R, Hotta A, Magness S, Metzger D, Biernaskie J Hair follicle dermal stem cells regenerate the dermal sheath, repopulate the dermal papilla, and modulate hair type. Hair follicle dermal stem cells regenerate the dermal sheath, repopulate the dermal papilla, and modulate hair type. Hair follicle dermal stem cells regenerate the dermal sheath, repopulate the dermal papilla, and modulate hair type. Developmental Cell, 31, 5, 543-558 Developmental Cell, 31, 5, 543-558 Developmental Cell, 31, 5, 543-558 2014/12 Refereed English Research paper(scientific journal) Disclose to all
Hotta, A and Yamanaka, S. Hotta, A and Yamanaka, S. Hotta, A and Yamanaka, S. Induced Pluripotent Stem Cells Induced Pluripotent Stem Cells Induced Pluripotent Stem Cells Biomaterials and Regenerative Medicine, 19-33 Biomaterials and Regenerative Medicine, 19-33 Biomaterials and Regenerative Medicine, 19-33 2014/09/29 English Research paper(international conference proceedings) Disclose to all
Kondo T, Funayama M, Tsukita K, Hotta A, Yasuda A, Nori S, Kaneko S, Nakamura M, Takahashi R, Okano H, Yamanaka S, Inoue H Kondo T, Funayama M, Tsukita K, Hotta A, Yasuda A, Nori S, Kaneko S, Nakamura M, Takahashi R, Okano H, Yamanaka S, Inoue H Kondo T, Funayama M, Tsukita K, Hotta A, Yasuda A, Nori S, Kaneko S, Nakamura M, Takahashi R, Okano H, Yamanaka S, Inoue H Focal transplantation of human iPSC-derived glial-rich neural progenitors improves lifespan of ALS mice. Focal transplantation of human iPSC-derived glial-rich neural progenitors improves lifespan of ALS mice. Focal transplantation of human iPSC-derived glial-rich neural progenitors improves lifespan of ALS mice. Stem Cell Reports, 3, 2, 242-249 Stem Cell Reports, 3, 2, 242-249 Stem Cell Reports, 3, 2, 242-249 2014/08 Refereed English Research paper(scientific journal) Disclose to all
李 紅梅, 堀田秋津 李 紅梅, 堀田秋津 CRISPR/Casを用いた遺伝子治療への展望 CRISPR/Casを用いた遺伝子治療への展望 実験医学, 32, 11, 1726-1731 実験医学, 32, 11, 1726-1731 , 32, 11, 1726-1731 2014/07/01 Japanese Research paper(scientific journal) Disclose to all
堀田秋津 堀田秋津 細胞種変換を支える遺伝子導入技術 細胞種変換を支える遺伝子導入技術 細胞, 46, 5, 220-224 細胞, 46, 5, 220-224 , 46, 5, 220-224 2014/04/21 Japanese Research paper(scientific journal) Disclose to all
H. Lisa Li; T. Nakano; A. Hotta H. Lisa Li; T. Nakano; A. Hotta H. Lisa Li; T. Nakano; A. Hotta Genetic correction using engineered nucleases for gene therapy applications Genetic correction using engineered nucleases for gene therapy applications Genetic correction using engineered nucleases for gene therapy applications Development Growth and Differentiation, 56, 1, 63-77 Development Growth and Differentiation, 56, 1, 63-77 Development Growth and Differentiation, 56, 1, 63-77 2014/01 Refereed English Research paper(scientific journal) Disclose to all
Matsui H, Fujimoto N, Sasakawa N, Ohinata Y, Shima M, Yamanaka S, Sugimoto M, Hotta A Matsui H, Fujimoto N, Sasakawa N, Ohinata Y, Shima M, Yamanaka S, Sugimoto M, Hotta A Matsui H, Fujimoto N, Sasakawa N, Ohinata Y, Shima M, Yamanaka S, Sugimoto M, Hotta A Delivery of full-length factor VIII using a piggyBac transposon vector to correct a mouse model of hemophilia A. Delivery of full-length factor VIII using a piggyBac transposon vector to correct a mouse model of hemophilia A. Delivery of full-length factor VIII using a piggyBac transposon vector to correct a mouse model of hemophilia A. PLoS ONE, 9, 8 PLoS ONE, 9, 8 PLoS ONE, 9, 8 2014 Refereed English Research paper(scientific journal) Disclose to all
李 紅梅,Knut Woltjen,高橋和利,山中伸弥,堀田秋津. 李 紅梅,Knut Woltjen,高橋和利,山中伸弥,堀田秋津. TALENを用いたヒトiPS細胞におけるゲノム編集 TALENを用いたヒトiPS細胞におけるゲノム編集 細胞工学, 32, 5, 526-531 細胞工学, 32, 5, 526-531 , 32, 5, 526-531 2013/04/22 Japanese Research paper(scientific journal) Disclose to all
A. Tanaka; K. Woltjen; K. Miyake; A. Hotta; M. Ikeya; T. Yamamoto; T. Nishino; E. Shoji; A. Sehara-Fujisawa; Y. Manabe; N. Fujii; K. Hanaoka; T. Era; S. Yamashita; K.-I. Isobe; E. Kimura; H. Sakurai A. Tanaka; K. Woltjen; K. Miyake; A. Hotta; M. Ikeya; T. Yamamoto; T. Nishino; E. Shoji; A. Sehara-Fujisawa; Y. Manabe; N. Fujii; K. Hanaoka; T. Era; S. Yamashita; K.-I. Isobe; E. Kimura; H. Sakurai A. Tanaka; K. Woltjen; K. Miyake; A. Hotta; M. Ikeya; T. Yamamoto; T. Nishino; E. Shoji; A. Sehara-Fujisawa; Y. Manabe; N. Fujii; K. Hanaoka; T. Era; S. Yamashita; K.-I. Isobe; E. Kimura; H. Sakurai Efficient and Reproducible Myogenic Differentiation from Human iPS Cells: Prospects for Modeling Miyoshi Myopathy In Vitro Efficient and Reproducible Myogenic Differentiation from Human iPS Cells: Prospects for Modeling Miyoshi Myopathy In Vitro Efficient and Reproducible Myogenic Differentiation from Human iPS Cells: Prospects for Modeling Miyoshi Myopathy In Vitro PLoS ONE, 8, 4 PLoS ONE, 8, 4 PLoS ONE, 8, 4 2013 Refereed English Research paper(scientific journal) Disclose to all
A. Yamashita; S. Liu; K. Woltjen; B. Thomas; G. Meng; A. Hotta; K. Takahashi; J. Ellis; S. Yamanaka; D.E. Rancourt A. Yamashita; S. Liu; K. Woltjen; B. Thomas; G. Meng; A. Hotta; K. Takahashi; J. Ellis; S. Yamanaka; D.E. Rancourt A. Yamashita; S. Liu; K. Woltjen; B. Thomas; G. Meng; A. Hotta; K. Takahashi; J. Ellis; S. Yamanaka; D.E. Rancourt Cartilage tissue engineering identifies abnormal human induced pluripotent stem cells Cartilage tissue engineering identifies abnormal human induced pluripotent stem cells Cartilage tissue engineering identifies abnormal human induced pluripotent stem cells Scientific Reports, 3 Scientific Reports, 3 Scientific Reports, 3 2013 Refereed English Research paper(scientific journal) Disclose to all
A. Morizane; D. Doi; T. Kikuchi; K. Okita; A. Hotta; T. Kawasaki; T. Hayashi; H. Onoe; T. Shiina; S. Yamanaka; J. Takahashi A. Morizane; D. Doi; T. Kikuchi; K. Okita; A. Hotta; T. Kawasaki; T. Hayashi; H. Onoe; T. Shiina; S. Yamanaka; J. Takahashi A. Morizane; D. Doi; T. Kikuchi; K. Okita; A. Hotta; T. Kawasaki; T. Hayashi; H. Onoe; T. Shiina; S. Yamanaka; J. Takahashi Direct comparison of autologous and allogeneic transplantation of IPSC-derived neural cells in the brain of a nonhuman primate Direct comparison of autologous and allogeneic transplantation of IPSC-derived neural cells in the brain of a nonhuman primate Direct comparison of autologous and allogeneic transplantation of IPSC-derived neural cells in the brain of a nonhuman primate Stem Cell Reports, 1, 4, 283-292 Stem Cell Reports, 1, 4, 283-292 Stem Cell Reports, 1, 4, 283-292 2013 Refereed English Research paper(scientific journal) Disclose to all
A.Y.L. Cheung; L.M. Horvath; D. Grafodatskaya; P. Pasceri; R. Weksberg; A. Hotta; L. Carrel; J. Ellis A.Y.L. Cheung; L.M. Horvath; D. Grafodatskaya; P. Pasceri; R. Weksberg; A. Hotta; L. Carrel; J. Ellis A.Y.L. Cheung; L.M. Horvath; D. Grafodatskaya; P. Pasceri; R. Weksberg; A. Hotta; L. Carrel; J. Ellis Isolation of MECP2-null Rett Syndrome patient hiPS cells and isogenic controls through X-chromosome inactivation Isolation of MECP2-null Rett Syndrome patient hiPS cells and isogenic controls through X-chromosome inactivation Isolation of MECP2-null Rett Syndrome patient hiPS cells and isogenic controls through X-chromosome inactivation Human Molecular Genetics, 20, 11, 2103-2115 Human Molecular Genetics, 20, 11, 2103-2115 Human Molecular Genetics, 20, 11, 2103-2115 2011/06/01 Refereed English Research paper(scientific journal) Disclose to all
E. Fussner; U. Djuric; M. Strauss; A. Hotta; C. Perez-Iratxeta; F. Lanner; F.J. Dilworth; J. Ellis; D.P. Bazett-Jones E. Fussner; U. Djuric; M. Strauss; A. Hotta; C. Perez-Iratxeta; F. Lanner; F.J. Dilworth; J. Ellis; D.P. Bazett-Jones E. Fussner; U. Djuric; M. Strauss; A. Hotta; C. Perez-Iratxeta; F. Lanner; F.J. Dilworth; J. Ellis; D.P. Bazett-Jones Constitutive heterochromatin reorganization during somatic cell reprogramming Constitutive heterochromatin reorganization during somatic cell reprogramming Constitutive heterochromatin reorganization during somatic cell reprogramming EMBO Journal, 30, 9, 1778-1789 EMBO Journal, 30, 9, 1778-1789 EMBO Journal, 30, 9, 1778-1789 2011/05/04 Refereed English Research paper(scientific journal) Disclose to all
堀田秋津 堀田秋津 iPS細胞の小分子制御 iPS細胞の小分子制御 学術の動向, 16, 5, 62-65 学術の動向, 16, 5, 62-65 , 16, 5, 62-65 2011/05/01 Japanese Research paper(scientific journal) Disclose to all
T. Kinoshita; G. Nagamatsu; T. Kosaka; K. Takubo; A. Hotta; J. Ellis; T. Suda T. Kinoshita; G. Nagamatsu; T. Kosaka; K. Takubo; A. Hotta; J. Ellis; T. Suda T. Kinoshita; G. Nagamatsu; T. Kosaka; K. Takubo; A. Hotta; J. Ellis; T. Suda Ataxia-telangiectasia mutated (ATM) deficiency decreases reprogramming efficiency and leads to genomic instability in iPS cells Ataxia-telangiectasia mutated (ATM) deficiency decreases reprogramming efficiency and leads to genomic instability in iPS cells Ataxia-telangiectasia mutated (ATM) deficiency decreases reprogramming efficiency and leads to genomic instability in iPS cells Biochemical and Biophysical Research Communications, 407, 2, 321-326 Biochemical and Biophysical Research Communications, 407, 2, 321-326 Biochemical and Biophysical Research Communications, 407, 2, 321-326 2011/04 Refereed English Research paper(scientific journal) Disclose to all
S.J. Kattman; A.D. Witty; M. Gagliardi; N.C. Dubois; M. Niapour; A. Hotta; J. Ellis; G. Keller S.J. Kattman; A.D. Witty; M. Gagliardi; N.C. Dubois; M. Niapour; A. Hotta; J. Ellis; G. Keller S.J. Kattman; A.D. Witty; M. Gagliardi; N.C. Dubois; M. Niapour; A. Hotta; J. Ellis; G. Keller Stage-specific optimization of activin/nodal and BMP signaling promotes cardiac differentiation of mouse and human pluripotent stem cell lines Stage-specific optimization of activin/nodal and BMP signaling promotes cardiac differentiation of mouse and human pluripotent stem cell lines Stage-specific optimization of activin/nodal and BMP signaling promotes cardiac differentiation of mouse and human pluripotent stem cell lines Cell Stem Cell, 8, 2, 228-240 Cell Stem Cell, 8, 2, 228-240 Cell Stem Cell, 8, 2, 228-240 2011/02/04 Refereed English Research paper(scientific journal) Disclose to all
K. Sciabica; K. Woltjen; A. Hotta K. Sciabica; K. Woltjen; A. Hotta K. Sciabica; K. Woltjen; A. Hotta Obtaining pluripotency biomarker signatures Obtaining pluripotency biomarker signatures Obtaining pluripotency biomarker signatures Genetic Engineering and Biotechnology News, 30, 3, 1-3 Genetic Engineering and Biotechnology News, 30, 3, 1-3 Genetic Engineering and Biotechnology News, 30, 3, 1-3 2010 English Research paper(bulletin of university, research institution) Disclose to all
M. Rastegar; A. Hotta; P. Pasceri; M. Makarem; A.Y.L. Cheung; S. Elliott; K.J. Park; M. Adachi; F.S. Jones; I.D. Clarke; P. Dirks; J. Ellis M. Rastegar; A. Hotta; P. Pasceri; M. Makarem; A.Y.L. Cheung; S. Elliott; K.J. Park; M. Adachi; F.S. Jones; I.D. Clarke; P. Dirks; J. Ellis M. Rastegar; A. Hotta; P. Pasceri; M. Makarem; A.Y.L. Cheung; S. Elliott; K.J. Park; M. Adachi; F.S. Jones; I.D. Clarke; P. Dirks; J. Ellis MECP2 isoform-specific vectors with regulated expression for Rett Syndrome gene therapy MECP2 isoform-specific vectors with regulated expression for Rett Syndrome gene therapy MECP2 isoform-specific vectors with regulated expression for Rett Syndrome gene therapy PLoS ONE, 4, 8 PLoS ONE, 4, 8 PLoS ONE, 4, 8 2009/08 Refereed English Research paper(scientific journal) Disclose to all
A. Hotta; A.Y.L. Cheung; N. Farra; K. Vijayaragavan; C.A. S?guin; J.S. Draper; P. Pasceri; I.A. Maksakova; D.L. Mager; J. Rossant; M. Bhatia; J. Ellis A. Hotta; A.Y.L. Cheung; N. Farra; K. Vijayaragavan; C.A. S?guin; J.S. Draper; P. Pasceri; I.A. Maksakova; D.L. Mager; J. Rossant; M. Bhatia; J. Ellis A. Hotta; A.Y.L. Cheung; N. Farra; K. Vijayaragavan; C.A. S?guin; J.S. Draper; P. Pasceri; I.A. Maksakova; D.L. Mager; J. Rossant; M. Bhatia; J. Ellis Isolation of human iPS cells using EOS lentiviral vectors to select for pluripotency Isolation of human iPS cells using EOS lentiviral vectors to select for pluripotency Isolation of human iPS cells using EOS lentiviral vectors to select for pluripotency Nature Methods, 6, 5, 370-376 Nature Methods, 6, 5, 370-376 Nature Methods, 6, 5, 370-376 2009/05 Refereed English Research paper(scientific journal) Disclose to all
A. Hotta; A.Y.L. Cheung; N. Farra; K. Garcha; W.Y. Chang; P. Pasceri; W.L. Stanford; J. Ellis A. Hotta; A.Y.L. Cheung; N. Farra; K. Garcha; W.Y. Chang; P. Pasceri; W.L. Stanford; J. Ellis A. Hotta; A.Y.L. Cheung; N. Farra; K. Garcha; W.Y. Chang; P. Pasceri; W.L. Stanford; J. Ellis EOS lentiviral vector selection system for human induced pluripotent stem cells EOS lentiviral vector selection system for human induced pluripotent stem cells EOS lentiviral vector selection system for human induced pluripotent stem cells Nature Protocols, 4, 12, 1828-1844 Nature Protocols, 4, 12, 1828-1844 Nature Protocols, 4, 12, 1828-1844 2009 Refereed English Research paper(scientific journal) Disclose to all
A. Hotta; J. Ellis A. Hotta; J. Ellis A. Hotta; J. Ellis Retroviral vector silencing during iPS cell induction: An epigenetic beacon that signals distinct pluripotent states Retroviral vector silencing during iPS cell induction: An epigenetic beacon that signals distinct pluripotent states Retroviral vector silencing during iPS cell induction: An epigenetic beacon that signals distinct pluripotent states Journal of Cellular Biochemistry, 105, 4, 940-948 Journal of Cellular Biochemistry, 105, 4, 940-948 Journal of Cellular Biochemistry, 105, 4, 940-948 2008/11 Refereed English Research paper(scientific journal) Disclose to all
A. Buzina; M.Y.M. Lo; A. Moffett; A. Hotta; E. Fussner; R.R. Bharadwaj; P. Pasceri; J.V. Garcia-Martinez; D.P. Bazett-Jones; J. Ellis A. Buzina; M.Y.M. Lo; A. Moffett; A. Hotta; E. Fussner; R.R. Bharadwaj; P. Pasceri; J.V. Garcia-Martinez; D.P. Bazett-Jones; J. Ellis A. Buzina; M.Y.M. Lo; A. Moffett; A. Hotta; E. Fussner; R.R. Bharadwaj; P. Pasceri; J.V. Garcia-Martinez; D.P. Bazett-Jones; J. Ellis β-globin LCR and intron elements cooperate and direct spatial reorganization for gene therapy β-globin LCR and intron elements cooperate and direct spatial reorganization for gene therapy β-globin LCR and intron elements cooperate and direct spatial reorganization for gene therapy PLoS Genetics, 4, 4 PLoS Genetics, 4, 4 PLoS Genetics, 4, 4 2008/04 Refereed English Research paper(scientific journal) Disclose to all
J. Ellis; A. Hotta; M. Rastegar J. Ellis; A. Hotta; M. Rastegar J. Ellis; A. Hotta; M. Rastegar Retrovirus Silencing by an Epigenetic TRIM Retrovirus Silencing by an Epigenetic TRIM Retrovirus Silencing by an Epigenetic TRIM Cell, 131, 1, 13-14 Cell, 131, 1, 13-14 Cell, 131, 1, 13-14 2007/10 Refereed English Research paper(scientific journal) Disclose to all
M. Morshed; M. Ando; J. Yamamoto; A. Hotta; H. Kaneoka; J. Kojima; K.-I. Nishijima; M. Kamihira; S. Iijima M. Morshed; M. Ando; J. Yamamoto; A. Hotta; H. Kaneoka; J. Kojima; K.-I. Nishijima; M. Kamihira; S. Iijima M. Morshed; M. Ando; J. Yamamoto; A. Hotta; H. Kaneoka; J. Kojima; K.-I. Nishijima; M. Kamihira; S. Iijima YY1 binds to regulatory element of chicken lysozyme and ovalbumin promoters YY1 binds to regulatory element of chicken lysozyme and ovalbumin promoters YY1 binds to regulatory element of chicken lysozyme and ovalbumin promoters Cytotechnology, 52, 3, 159-170 Cytotechnology, 52, 3, 159-170 Cytotechnology, 52, 3, 159-170 2006/11 Refereed English Research paper(scientific journal) Disclose to all
A. Hotta; Y. Saito; K. Kyogoku; Y. Kawabe; K.-i. Nishijima; M. Kamihira; S. Iijima A. Hotta; Y. Saito; K. Kyogoku; Y. Kawabe; K.-i. Nishijima; M. Kamihira; S. Iijima A. Hotta; Y. Saito; K. Kyogoku; Y. Kawabe; K.-i. Nishijima; M. Kamihira; S. Iijima Characterization of transient expression system for retroviral vector production Characterization of transient expression system for retroviral vector production Characterization of transient expression system for retroviral vector production Journal of Bioscience and Bioengineering, 101, 4, 361-368 Journal of Bioscience and Bioengineering, 101, 4, 361-368 Journal of Bioscience and Bioengineering, 101, 4, 361-368 2006/04 Refereed English Research paper(scientific journal) Disclose to all
Akitsu Hotta, Yoshikazu Saito, Ken-Ichi Nishijima, Masamichi Kamihira, Shinji Iijima Akitsu Hotta, Yoshikazu Saito, Ken-Ichi Nishijima, Masamichi Kamihira, Shinji Iijima Akitsu Hotta, Yoshikazu Saito, Ken-Ichi Nishijima, Masamichi Kamihira, Shinji Iijima Preparation of high-titer retroviral vectors using transient expression system. Preparation of high-titer retroviral vectors using transient expression system. Preparation of high-titer retroviral vectors using transient expression system. Animal Cell Technology: Basic & Applied Aspects, 14, 293-299 Animal Cell Technology: Basic & Applied Aspects, 14, 293-299 Animal Cell Technology: Basic & Applied Aspects, 14, 293-299 2006 English Research paper(international conference proceedings) Disclose to all
A. Hotta, K. Ono, S. Mizuarai, K. Yamaguchi, K. Nishijima, M. Kamihira, S. Iijima A. Hotta, K. Ono, S. Mizuarai, K. Yamaguchi, K. Nishijima, M. Kamihira, S. Iijima A. Hotta, K. Ono, S. Mizuarai, K. Yamaguchi, K. Nishijima, M. Kamihira, S. Iijima Production of pharmaceutical proteins by transgenic avian. Production of pharmaceutical proteins by transgenic avian. Production of pharmaceutical proteins by transgenic avian. Animal Cell Technology: Basic & Applied Aspects, 13, 299-303 Animal Cell Technology: Basic & Applied Aspects, 13, 299-303 Animal Cell Technology: Basic & Applied Aspects, 13, 299-303 2004 English Research paper(international conference proceedings) Disclose to all
Hotta A, Kamihira M, Itoh K, Morshed M, Kawabe Y, Ono K, Matsumoto H, Nishijima K, Iijima S Hotta A, Kamihira M, Itoh K, Morshed M, Kawabe Y, Ono K, Matsumoto H, Nishijima K, Iijima S Hotta A, Kamihira M, Itoh K, Morshed M, Kawabe Y, Ono K, Matsumoto H, Nishijima K, Iijima S Production of anti-CD2 chimeric antibody by recombinant animal cells. Production of anti-CD2 chimeric antibody by recombinant animal cells. Production of anti-CD2 chimeric antibody by recombinant animal cells. Journal of bioscience and bioengineering, 98, 4, 298-303 Journal of bioscience and bioengineering, 98, 4, 298-303 Journal of bioscience and bioengineering, 98, 4, 298-303 2004 Refereed English Research paper(scientific journal) Disclose to all
K.-I. Ono; M. Kamihira; Y. Kuga; H. Matsumoto; A. Hotta; T. Itoh; K.-I. Nishijima; N. Nakamura; H. Matsuda; S. Iijima K.-I. Ono; M. Kamihira; Y. Kuga; H. Matsumoto; A. Hotta; T. Itoh; K.-I. Nishijima; N. Nakamura; H. Matsuda; S. Iijima K.-I. Ono; M. Kamihira; Y. Kuga; H. Matsumoto; A. Hotta; T. Itoh; K.-I. Nishijima; N. Nakamura; H. Matsuda; S. Iijima Production of anti-prion scFv-Fc fusion proteins by recombinant animal cells Production of anti-prion scFv-Fc fusion proteins by recombinant animal cells Production of anti-prion scFv-Fc fusion proteins by recombinant animal cells Journal of Bioscience and Bioengineering, 95, 3, 231-238 Journal of Bioscience and Bioengineering, 95, 3, 231-238 Journal of Bioscience and Bioengineering, 95, 3, 231-238 2003/03 Refereed English Research paper(scientific journal) Disclose to all

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Conference Activities & Talks
Title Title(Japanese) Title(English) Conference Conference(Japanese) Conference(English) Promotor Promotor(Japanese) Promotor(English) Date Language Assortment Disclose
Precise control of CRISPR-Cas9 mediated gene editing for correcting mutation of Duchenne muscular dystrophy in iPS Cells Precise control of CRISPR-Cas9 mediated gene editing for correcting mutation of Duchenne muscular dystrophy in iPS Cells Precise control of CRISPR-Cas9 mediated gene editing for correcting mutation of Duchenne muscular dystrophy in iPS Cells American Society of Gene & Cell Therapy (ASGCT) 18th Annual Meeting American Society of Gene & Cell Therapy (ASGCT) 18th Annual Meeting American Society of Gene & Cell Therapy (ASGCT) 18th Annual Meeting 2015 Disclose to all
TALENおよびCRISPRを用いた高効率かつ高精度な筋ジストロフィーiPS細胞の遺伝子修復 TALENおよびCRISPRを用いた高効率かつ高精度な筋ジストロフィーiPS細胞の遺伝子修復 TALENおよびCRISPRを用いた高効率かつ高精度な筋ジストロフィーiPS細胞の遺伝子修復 第14回日本再生医療学会総会 第14回日本再生医療学会総会 第14回日本再生医療学会総会 2015 Disclose to all
Precise Correction of the Dystrophin Gene in Duchenne Muscular Dystrophy Patient Induced Pluripotent Stem Cells by TALEN and CRISPR-Cas9 Precise Correction of the Dystrophin Gene in Duchenne Muscular Dystrophy Patient Induced Pluripotent Stem Cells by TALEN and CRISPR-Cas9 Precise Correction of the Dystrophin Gene in Duchenne Muscular Dystrophy Patient Induced Pluripotent Stem Cells by TALEN and CRISPR-Cas9 Cambridge Healthtech Institute’s Inaugural New Frontiers in Gene Editing Part of the 22nd International Molecular Medicine Tri-Conference Cambridge Healthtech Institute’s Inaugural New Frontiers in Gene Editing Part of the 22nd International Molecular Medicine Tri-Conference Cambridge Healthtech Institute’s Inaugural New Frontiers in Gene Editing Part of the 22nd International Molecular Medicine Tri-Conference 2015 Disclose to all
Multicolor labeling system for tracking long-term expression and cell-to-cell heterogeneity. Multicolor labeling system for tracking long-term expression and cell-to-cell heterogeneity. Multicolor labeling system for tracking long-term expression and cell-to-cell heterogeneity. Takeda International Symposium Takeda International Symposium Takeda International Symposium 2015 Disclose to all
iPS細胞でゲノムを手術してジストロフィン変異を修復する[Invited] iPS細胞でゲノムを手術してジストロフィン変異を修復する [Invited] iPS細胞でゲノムを手術してジストロフィン変異を修復する [Invited] 筋ジストロフィ−合同班会議 市民公開講座 筋ジストロフィ−合同班会議 市民公開講座 筋ジストロフィ−合同班会議 市民公開講座 2015 Disclose to all
Towards gene therapy using iPS cells: transposon and genome editing technologies[Invited] Towards gene therapy using iPS cells: transposon and genome editing technologies [Invited] Towards gene therapy using iPS cells: transposon and genome editing technologies [Invited] 第7回NAGOYA グローバルリトリート 第7回NAGOYA グローバルリトリート 第7回NAGOYA グローバルリトリート 2015 Disclose to all
Precise Editing of iPS Cell Genome: Perspectives on DMD Gene Therapy[Invited] Precise Editing of iPS Cell Genome: Perspectives on DMD Gene Therapy [Invited] Precise Editing of iPS Cell Genome: Perspectives on DMD Gene Therapy [Invited] 第5回新潟大学脳研究所共同研究拠点国際シンポジウム 第5回新潟大学脳研究所共同研究拠点国際シンポジウム 第5回新潟大学脳研究所共同研究拠点国際シンポジウム 2015 English Disclose to all
疾患iPS細胞における病原変異遺伝子のゲノム手術[Invited] 疾患iPS細胞における病原変異遺伝子のゲノム手術 [Invited] 疾患iPS細胞における病原変異遺伝子のゲノム手術 [Invited] 第62回 日本実験動物学会 総会 第62回 日本実験動物学会 総会 第62回 日本実験動物学会 総会 2015 Disclose to all
ヒトゲノム配列を自在に書き換えるゲノム編集技術:change mode +w[Invited] ヒトゲノム配列を自在に書き換えるゲノム編集技術:change mode +w [Invited] ヒトゲノム配列を自在に書き換えるゲノム編集技術:change mode +w [Invited] NGS現場の会第四回研究会 NGS現場の会第四回研究会 NGS現場の会第四回研究会 2015 Disclose to all
Efficient gene correction of Duchunne muscular dystrophy mutation in iPS cells by TALENs and CRISPR-Cas9[Invited] Efficient gene correction of Duchunne muscular dystrophy mutation in iPS cells by TALENs and CRISPR-Cas9 [Invited] Efficient gene correction of Duchunne muscular dystrophy mutation in iPS cells by TALENs and CRISPR-Cas9 [Invited] 第21回日本遺伝子治療学会総会 第21回日本遺伝子治療学会総会 第21回日本遺伝子治療学会総会 2015 English Disclose to all
疾患iPS細胞における新規遺伝子修復戦略[Invited] 疾患iPS細胞における新規遺伝子修復戦略 [Invited] 疾患iPS細胞における新規遺伝子修復戦略 [Invited] 第39回 阿蘇シンポジウム 第39回 阿蘇シンポジウム 第39回 阿蘇シンポジウム 2015 Disclose to all
ゲノム編集の医療応用への可能性と課題[Invited] ゲノム編集の医療応用への可能性と課題 [Invited] ゲノム編集の医療応用への可能性と課題 [Invited] 国際高等研究所 研究プロジェクト 国際高等研究所 研究プロジェクト 国際高等研究所 研究プロジェクト 2015 Disclose to all
iPS細胞を用いた遺伝子治療戦略:トランスポゾンベクターとゲノム編集[Invited] iPS細胞を用いた遺伝子治療戦略:トランスポゾンベクターとゲノム編集 [Invited] iPS細胞を用いた遺伝子治療戦略:トランスポゾンベクターとゲノム編集 [Invited] 第15回遺伝子デリバリー研究会 第15回遺伝子デリバリー研究会 第15回遺伝子デリバリー研究会 2015 Disclose to all
ゲノム編集による効率的な遺伝子変異修復戦略[Invited] ゲノム編集による効率的な遺伝子変異修復戦略 [Invited] ゲノム編集による効率的な遺伝子変異修復戦略 [Invited] ゲノム創薬・医療フォーラム第2回シンポジウム ゲノム創薬・医療フォーラム第2回シンポジウム ゲノム創薬・医療フォーラム第2回シンポジウム 2015 Disclose to all
デュシェンヌ型筋ジストロフィー患者由来iPS細胞におけるTALENやCRISPRを用いたジストロフィン遺伝子の修復 デュシェンヌ型筋ジストロフィー患者由来iPS細胞におけるTALENやCRISPRを用いたジストロフィン遺伝子の修復 デュシェンヌ型筋ジストロフィー患者由来iPS細胞におけるTALENやCRISPRを用いたジストロフィン遺伝子の修復 第37回分子生物学会 第37回分子生物学会 第37回分子生物学会 2014 Disclose to all
Precise Gene Correction of Duchenne Muscular Dystrophy iPS cells using TALENs and CRISPR/Cas9 Precise Gene Correction of Duchenne Muscular Dystrophy iPS cells using TALENs and CRISPR/Cas9 Precise Gene Correction of Duchenne Muscular Dystrophy iPS cells using TALENs and CRISPR/Cas9 ISSCR ISSCR ISSCR 2014 Disclose to all
Engineered nuclease mediated genetic correction in iPSCs derived from Duchenne Muscular Dystrophy patient Engineered nuclease mediated genetic correction in iPSCs derived from Duchenne Muscular Dystrophy patient Engineered nuclease mediated genetic correction in iPSCs derived from Duchenne Muscular Dystrophy patient ASGCT ASGCT ASGCT 2014 Disclose to all
Stable and long-term expression of piggyBac vectors by the D4Z4 insulator in ES / iPS cells Stable and long-term expression of piggyBac vectors by the D4Z4 insulator in ES / iPS cells Stable and long-term expression of piggyBac vectors by the D4Z4 insulator in ES / iPS cells 武田シンポジウム 武田シンポジウム 武田シンポジウム 2014 Disclose to all
Genomic correction of Duchenne Muscular Dystrophy patient-derived iPSCs using engineered nucleases Genomic correction of Duchenne Muscular Dystrophy patient-derived iPSCs using engineered nucleases Genomic correction of Duchenne Muscular Dystrophy patient-derived iPSCs using engineered nucleases 武田シンポジウム 武田シンポジウム 武田シンポジウム 2014 Disclose to all
「研究者」という選択 〜iPS細胞との出会い〜[Invited] 「研究者」という選択 〜iPS細胞との出会い〜 [Invited] 「研究者」という選択 〜iPS細胞との出会い〜 [Invited] 志津南小学校 志津南小学校 志津南小学校 2014 Disclose to all
血友病Aに対する新規遺伝子/細胞治療戦略 〜トランスポゾンベクターによる遺伝子治療〜[Invited] 血友病Aに対する新規遺伝子/細胞治療戦略 〜トランスポゾンベクターによる遺伝子治療〜 [Invited] 血友病Aに対する新規遺伝子/細胞治療戦略 〜トランスポゾンベクターによる遺伝子治療〜 [Invited] 第36回日本血栓止血学会学術集会 第36回日本血栓止血学会学術集会 第36回日本血栓止血学会学術集会 2014 Disclose to all
TALENやCRISPRを用いた疾患iPS細胞のゲノム手術[Invited] TALENやCRISPRを用いた疾患iPS細胞のゲノム手術 [Invited] TALENやCRISPRを用いた疾患iPS細胞のゲノム手術 [Invited] 第35回日本炎症・再生医学会 第35回日本炎症・再生医学会 第35回日本炎症・再生医学会 2014 Disclose to all
ゲノム編集技術を用いたiPS細胞での遺伝子治療[Invited] ゲノム編集技術を用いたiPS細胞での遺伝子治療 [Invited] ゲノム編集技術を用いたiPS細胞での遺伝子治療 [Invited] 東大分生研セミナー 東大分生研セミナー 東大分生研セミナー 2014 Disclose to all
Duchenne型筋ジストロフィーiPS細胞の遺伝子修復とゲノムワイド変異解析[Invited] Duchenne型筋ジストロフィーiPS細胞の遺伝子修復とゲノムワイド変異解析 [Invited] Duchenne型筋ジストロフィーiPS細胞の遺伝子修復とゲノムワイド変異解析 [Invited] 第4回ゲノム研究編集研究会 第4回ゲノム研究編集研究会 第4回ゲノム研究編集研究会 2014 Disclose to all
TALENおよびCRISPR/Cas9を利用した疾患iPS細胞の遺伝子修復[Invited] TALENおよびCRISPR/Cas9を利用した疾患iPS細胞の遺伝子修復 [Invited] TALENおよびCRISPR/Cas9を利用した疾患iPS細胞の遺伝子修復 [Invited] 第87回日本生化学会 第87回日本生化学会 第87回日本生化学会 2014 Disclose to all
ゲノム編集技術を用いたDMD患者由来iPS細胞での遺伝子治療[Invited] ゲノム編集技術を用いたDMD患者由来iPS細胞での遺伝子治療 [Invited] ゲノム編集技術を用いたDMD患者由来iPS細胞での遺伝子治療 [Invited] 筋ジストロフィーモデル動物を用いた新たな治療法の開発 平成26年度 研究班会議プログラム 筋ジストロフィーモデル動物を用いた新たな治療法の開発 平成26年度 研究班会議プログラム 筋ジストロフィーモデル動物を用いた新たな治療法の開発 平成26年度 研究班会議プログラム 2014 Disclose to all
Duchenne型筋ジストロフィー患者由来iPS細胞におけるTALENを用いたゲノム上での遺伝子修復 Duchenne型筋ジストロフィー患者由来iPS細胞におけるTALENを用いたゲノム上での遺伝子修復 Duchenne型筋ジストロフィー患者由来iPS細胞におけるTALENを用いたゲノム上での遺伝子修復 第三回ゲノム編集研究会 第三回ゲノム編集研究会 第三回ゲノム編集研究会 2013 Disclose to all
Genomic correction of Duchenne Muscular Dystrophy patient-derived iPSCs using TALENs Genomic correction of Duchenne Muscular Dystrophy patient-derived iPSCs using TALENs Genomic correction of Duchenne Muscular Dystrophy patient-derived iPSCs using TALENs The ASGCT 16th Annual Meeting The ASGCT 16th Annual Meeting The ASGCT 16th Annual Meeting 2013 Disclose to all
Long-Term Phenotypic Correction of Hemophilia A by Non-Viral PiggyBac Transposon Vector Long-Term Phenotypic Correction of Hemophilia A by Non-Viral PiggyBac Transposon Vector Long-Term Phenotypic Correction of Hemophilia A by Non-Viral PiggyBac Transposon Vector The ASGCT 16th Annual Meeting The ASGCT 16th Annual Meeting The ASGCT 16th Annual Meeting 2013 Disclose to all
ヒト由来インシュレーターを搭載したトランスポゾンベクターによるES/iPS細胞での 長期安定発現 ヒト由来インシュレーターを搭載したトランスポゾンベクターによるES/iPS細胞での 長期安定発現 ヒト由来インシュレーターを搭載したトランスポゾンベクターによるES/iPS細胞での 長期安定発現 第12回 日本再生医療学会総会 第12回 日本再生医療学会総会 第12回 日本再生医療学会総会 2013 Disclose to all
ヒトiPS細胞におけるゲノム編集技術を用いた遺伝子異常修復[Invited] ヒトiPS細胞におけるゲノム編集技術を用いた遺伝子異常修復 [Invited] ヒトiPS細胞におけるゲノム編集技術を用いた遺伝子異常修復 [Invited] NGS現場の会 第三回 NGS現場の会 第三回 NGS現場の会 第三回 2013 Disclose to all
人工ヌクレアーゼ技術を利用したiPS細胞での遺伝子修復[Invited] 人工ヌクレアーゼ技術を利用したiPS細胞での遺伝子修復 [Invited] 人工ヌクレアーゼ技術を利用したiPS細胞での遺伝子修復 [Invited] Meet the Expert 2013 Meet the Expert 2013 Meet the Expert 2013 2013 Disclose to all
TALENやCRISPR/Cas9を用いたデュシェンヌ型筋ジストロフィー患者由来iPS細胞のゲノム手術[Invited] TALENやCRISPR/Cas9を用いたデュシェンヌ型筋ジストロフィー患者由来iPS細胞のゲノム手術 [Invited] TALENやCRISPR/Cas9を用いたデュシェンヌ型筋ジストロフィー患者由来iPS細胞のゲノム手術 [Invited] 第36回日本分子生物学会年会 第36回日本分子生物学会年会 第36回日本分子生物学会年会 2013 Disclose to all
Duchenne型筋ジストロフィー患者由来iPS細胞におけるTALENを用いたゲノム上でのエクソンスキッピング Duchenne型筋ジストロフィー患者由来iPS細胞におけるTALENを用いたゲノム上でのエクソンスキッピング Duchenne型筋ジストロフィー患者由来iPS細胞におけるTALENを用いたゲノム上でのエクソンスキッピング 第35回日本分子生物学会年会 第35回日本分子生物学会年会 第35回日本分子生物学会年会 2012 Disclose to all
トランスポゾン発現抑制を司る因子群のshRNAライブラリーによる全ゲノム規模探索 トランスポゾン発現抑制を司る因子群のshRNAライブラリーによる全ゲノム規模探索 トランスポゾン発現抑制を司る因子群のshRNAライブラリーによる全ゲノム規模探索 第35回日本分子生物学会年会 第35回日本分子生物学会年会 第35回日本分子生物学会年会 2012 Disclose to all
Establishment of the novel piggyBac transposon vector system for the treatment of hemophilia A Establishment of the novel piggyBac transposon vector system for the treatment of hemophilia A Establishment of the novel piggyBac transposon vector system for the treatment of hemophilia A 第74回日本血液学会学術集会 第74回日本血液学会学術集会 第74回日本血液学会学術集会 2012 Disclose to all
GENERATION OF CANINE IPS CELLS AND THEIR CHARACTERISTICS GENERATION OF CANINE IPS CELLS AND THEIR CHARACTERISTICS GENERATION OF CANINE IPS CELLS AND THEIR CHARACTERISTICS ISSCR 10th annual meeting ISSCR 10th annual meeting ISSCR 10th annual meeting 2012 Disclose to all
GENERATION FUNCTIONAL MYOCYTES FROM HUMAN INDUCED PLURIPOTENT STEM CELLS GENERATION FUNCTIONAL MYOCYTES FROM HUMAN INDUCED PLURIPOTENT STEM CELLS GENERATION FUNCTIONAL MYOCYTES FROM HUMAN INDUCED PLURIPOTENT STEM CELLS ISSCR 10th annual meeting ISSCR 10th annual meeting ISSCR 10th annual meeting 2012 Disclose to all
DERIVATION OF NANOG KNOCK-IN GFP REPORTER IPS CELL LINES USING MEGANUCLEASE-INDUCED HOMOLOGOUS RECOMBINATION DERIVATION OF NANOG KNOCK-IN GFP REPORTER IPS CELL LINES USING MEGANUCLEASE-INDUCED HOMOLOGOUS RECOMBINATION DERIVATION OF NANOG KNOCK-IN GFP REPORTER IPS CELL LINES USING MEGANUCLEASE-INDUCED HOMOLOGOUS RECOMBINATION ISSCR 10th annual meeting ISSCR 10th annual meeting ISSCR 10th annual meeting 2012 Disclose to all
FETAL EPIGENETIC MODIFIERS STIMULATE CARDIOMYOCYTE REGENERATION AND PROTECT FIBROSIS IN MAMMALIAN/AMPHIBIAN MODELS. FETAL EPIGENETIC MODIFIERS STIMULATE CARDIOMYOCYTE REGENERATION AND PROTECT FIBROSIS IN MAMMALIAN/AMPHIBIAN MODELS. FETAL EPIGENETIC MODIFIERS STIMULATE CARDIOMYOCYTE REGENERATION AND PROTECT FIBROSIS IN MAMMALIAN/AMPHIBIAN MODELS. ISSCR 10th annual meeting ISSCR 10th annual meeting ISSCR 10th annual meeting 2012 Disclose to all
SITE SPECIFIC GENOME EDITING OF HUMAN INDUCED PLURIPOTENT STEM CELLS BY PNA SITE SPECIFIC GENOME EDITING OF HUMAN INDUCED PLURIPOTENT STEM CELLS BY PNA SITE SPECIFIC GENOME EDITING OF HUMAN INDUCED PLURIPOTENT STEM CELLS BY PNA ISSCR 10th annual meeting ISSCR 10th annual meeting ISSCR 10th annual meeting 2012 Disclose to all
ヒト・マウスゲノムにおけるリピート領域のエピゲノム解析への挑戦 ヒト・マウスゲノムにおけるリピート領域のエピゲノム解析への挑戦 ヒト・マウスゲノムにおけるリピート領域のエピゲノム解析への挑戦 NGS現場の会 第2回研究会 NGS現場の会 第2回研究会 NGS現場の会 第2回研究会 2012 Disclose to all
Reprogramming the Structure of Constitutive Heterochromatin[Invited] Reprogramming the Structure of Constitutive Heterochromatin [Invited] Reprogramming the Structure of Constitutive Heterochromatin [Invited] 4th iCeMS Retreat 4th iCeMS Retreat 4th iCeMS Retreat 2012 English Disclose to all
Transposon Technologies Towards iPS Cell Gene Therapy[Invited] Transposon Technologies Towards iPS Cell Gene Therapy [Invited] Transposon Technologies Towards iPS Cell Gene Therapy [Invited] 理研CDBセミナー 理研CDBセミナー 理研CDBセミナー 2012 English Disclose to all
iPS細胞が分化万能性を獲得する過程におけるクロマチン高次構造の変化[Invited] iPS細胞が分化万能性を獲得する過程におけるクロマチン高次構造の変化 [Invited] iPS細胞が分化万能性を獲得する過程におけるクロマチン高次構造の変化 [Invited] 第40回北陸実験動物研究会 第40回北陸実験動物研究会 2011 Disclose to all
転写因子を用いた効率的なヒトiPS細胞からの骨格筋細胞誘導法の確立 転写因子を用いた効率的なヒトiPS細胞からの骨格筋細胞誘導法の確立 転写因子を用いた効率的なヒトiPS細胞からの骨格筋細胞誘導法の確立 第34回日本分子生物学会 第34回日本分子生物学会 第34回日本分子生物学会 2011 Disclose to all
REVEALING THE ONCOGENIC RISK OF HUMAN INDUCED PLURIPOTENT STEM CELLS USING IN VITRO CARTILAGE TISSUE ENGINEERING. REVEALING THE ONCOGENIC RISK OF HUMAN INDUCED PLURIPOTENT STEM CELLS USING IN VITRO CARTILAGE TISSUE ENGINEERING. REVEALING THE ONCOGENIC RISK OF HUMAN INDUCED PLURIPOTENT STEM CELLS USING IN VITRO CARTILAGE TISSUE ENGINEERING. ISSCR 9th Annual Meeting ISSCR 9th Annual Meeting ISSCR 9th Annual Meeting 2011 Disclose to all
ISOLATION OF MECP2-NULL RETT SYNDROME PATIENT HIPS CELLS AND ISOGENIC CONTROLS THROUGH X-CHROMOSOME INACTIVATION ISOLATION OF MECP2-NULL RETT SYNDROME PATIENT HIPS CELLS AND ISOGENIC CONTROLS THROUGH X-CHROMOSOME INACTIVATION ISOLATION OF MECP2-NULL RETT SYNDROME PATIENT HIPS CELLS AND ISOGENIC CONTROLS THROUGH X-CHROMOSOME INACTIVATION ISSCR 9th Annual Meeting ISSCR 9th Annual Meeting ISSCR 9th Annual Meeting 2011 Disclose to all
CONSTITUTIVE HETEROCHROMATIN REORGANIZATION DURING MOUSE SOMATIC CELL REPROGRAMMING CONSTITUTIVE HETEROCHROMATIN REORGANIZATION DURING MOUSE SOMATIC CELL REPROGRAMMING CONSTITUTIVE HETEROCHROMATIN REORGANIZATION DURING MOUSE SOMATIC CELL REPROGRAMMING ISSCR 9th Annual Meeting ISSCR 9th Annual Meeting ISSCR 9th Annual Meeting 2011 Disclose to all
Efficient and stable expression of non-viral vectors in human iPS cells[Invited] Efficient and stable expression of non-viral vectors in human iPS cells [Invited] Efficient and stable expression of non-viral vectors in human iPS cells [Invited] 2nd iCeMS retreat 2nd iCeMS retreat 2nd iCeMS retreat 2010 English Disclose to all
iPS cell reprogramming and chromatin architecture: How to distinguish high-quality iPS cells?[Invited] iPS cell reprogramming and chromatin architecture: How to distinguish high-quality iPS cells? [Invited] iPS cell reprogramming and chromatin architecture: How to distinguish high-quality iPS cells? [Invited] Stem Cells and Biomaterials Symposium Stem Cells and Biomaterials Symposium Stem Cells and Biomaterials Symposium 2010 English Disclose to all
Efficient and stable expression of non-viral vectors in human iPS cells: towards a gene therapy approach for hemophilia. Efficient and stable expression of non-viral vectors in human iPS cells: towards a gene therapy approach for hemophilia. Efficient and stable expression of non-viral vectors in human iPS cells: towards a gene therapy approach for hemophilia. ASM 2010 ASM 2010 ASM 2010 2010 Disclose to all
Conversion of partially-reprogrammed iPS cells into a fully-reprogrammed stage induces dynamic changes in heterochromatin ultrastructure. Conversion of partially-reprogrammed iPS cells into a fully-reprogrammed stage induces dynamic changes in heterochromatin ultrastructure. Conversion of partially-reprogrammed iPS cells into a fully-reprogrammed stage induces dynamic changes in heterochromatin ultrastructure. 第33回日本分子生物学会年会、第83回日本生化学会大会 合同大会 第33回日本分子生物学会年会、第83回日本生化学会大会 合同大会 第33回日本分子生物学会年会、第83回日本生化学会大会 合同大会 2010 Disclose to all

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Title language:
Books etc
Author Author(Japanese) Author(English) Title Title(Japanese) Title(English) Publisher Publisher(Japanese) Publisher(English) Publication date Language Type Disclose
李 紅梅, 佐伯涼太, 堀田秋津 李 紅梅, 佐伯涼太, 堀田秋津 再生医療2015 幹細胞と疾患iPS細胞の研究最前線 再生医療2015 幹細胞と疾患iPS細胞の研究最前線 羊土社 羊土社 2015 Disclose to all
Li, LH and Hotta, A. Li, LH and Hotta, A. Li, LH and Hotta, A. Targeted Genome Editing Using Site-Specific Nucleases Targeted Genome Editing Using Site-Specific Nucleases Targeted Genome Editing Using Site-Specific Nucleases Springer Springer Springer 2015 Disclose to all
李 紅梅,佐久間哲史,堀田秋津, 山本 卓. 李 紅梅,佐久間哲史,堀田秋津, 山本 卓. ES・iPS細胞実験スタンダード ES・iPS細胞実験スタンダード 羊土社 羊土社 2014 Disclose to all
Hotta, A and Yamanaka, S. Hotta, A and Yamanaka, S. Hotta, A and Yamanaka, S. Biomaterials and Regenerative Medicine Biomaterials and Regenerative Medicine Biomaterials and Regenerative Medicine Cambridge University Press Cambridge University Press Cambridge University Press 2014 Disclose to all
Title language:
External funds: competitive funds and Grants-in-Aid for Scientific Research (Kakenhi)
Type Position Title(Japanese) Title(English) Period
研究活動スタート支援 Representative iPS細胞の遺伝子治療戦略を可能とする非ウイルス型ベクターの開発 2010/04/01-2011/03/31
若手研究(B) Representative 新規shRNAライブラリーによる多能性幹細胞のゆらぎの分子機構同定 2013/04/01-2015/03/31
基盤研究(B) Assignment 自己細胞移植による次世代型血友病A治療の創出 2013/04/01-2016/03/31
若手研究(A) Representative 細胞内作用場の制御による遺伝子変異修復技術開発 2015/04/01-2018/03/31
基盤研究(A) Assignment iPS細胞を用いた肺の臓器再生と疾患病態解明のための革新的バイオリソースの開発 2015/04/01-2018/03/31
若手研究(A) Representative 細胞内作用場の制御による遺伝子変異修復技術開発 2015/04/01-2016/03/31
External funds: other than those above
System Main person Title(Japanese) Title(English) Period
上原記念生命科学財団 堀田秋津 血友病の新規iPS細胞遺伝子治療戦略 2011/01/19-2012/03/31
持田記念研究助成金 堀田秋津 iPS細胞での長期安定発現を可能とするヒト由来インシュレーターの活用および作用機構解明 2012/09/28-2013/03/31
バクスター 凝固関連研究基金(BCRF) 堀田秋津 iPS細胞を用いた次世代型血友病治療の創出 2013/01/-2014/02/28
独立行政法人科学技術振興機構 さきがけ 堀田秋津 人為的核内環境制御による高品質iPS細胞の誘導 2010/10/01-2014/03/31
独立行政法人科学技術振興機構 再生医療実現拠点ネットワークプログラム 技術開発個別課題 竹内 純 心機能再生を目指した特定因子による細胞変換技術開発 2013/07/08-2014/03/31
独立行政法人科学技術振興機構 再生医療実現拠点ネットワークプログラム 中核拠点 山中 伸弥 再生医療用iPS細胞ストック開発拠点 2013/07/08-2023/03/31
国立研究開発法人日本医療研究開発機構 再生医療実現拠点ネットワークプログラム(疾患特異的iPS細胞の利活用促進・難病研究加速プログラム) 櫻井 英俊 筋疾患に対する治療薬の創出を目指した研究 2017/08/29-2022/03/31
国立研究開発法人日本医療研究開発機構 難治性疾患実用化研究事業 堀田秋津 独自送達技術開発による先天性筋疾患に対するゲノム編集治療法の開発 2017/11/29-2020/03/31
Teaching subject(s)
Name(Japanese) Name(English) Term Department Period
iPS細胞入門 An introduction to iPS cells 前期 全学共通科目 2014/04-2015/03
iPS細胞入門 An introduction to iPS cells 前期 全学共通科目 2015/04-2016/03
ILASセミナー ILAS Seminar 前期 全学共通科目 2016/04-2017/03
ILASセミナー ILAS Seminar 前期 全学共通科目 2017/04-2018/03
ILASセミナー ILAS Seminar 前期 全学共通科目 2018/04-2019/03
School management (title, position)
Title Period
組換えDNA実験安全副主任者 -
Faculty management (title, position)
Title Period
組換えDNA実験安全委員会 -
情報管理委員会 2015/04/01-
倫理審査委員会 2017/09/29-
CiRA研究インターンシップ委員会 2016/04/01-
Other activities (awards)
Award name Organization name Date
Best Poster Presentation Award カナダ幹細胞ネットワーク(SCN)年次大会 2008
Exceptional Trainee Award トロント小児病院(Sickkids) 2009
科学技術分野の文部科学大臣表彰 若手科学者賞 文部科学省 2016/04/12