原 崇裕

Last Update: 2020/07/24 15:49:53

Print

Name(Kanji/Kana/Abecedarium Latinum)
原 崇裕/ハラ タカヒロ/Hara, Takahiro
Primary Affiliation(Org1/Job title)
Institute for Frontier Life and Medical Sciences/Assistant Professor
Affiliated programs (koza)
Org1 Job title
Graduate Schools Medicine Assistant Professor
Graduate Schools Medicine Assistant Professor
Graduate Schools Pharmaceutical Sciences Assistant Professor
Academic Organizations You are Affiliated to in Japan
Organization name(Japanese) Organization name(English)
日本生化学会 The Japanese Biochemical Society
日本免疫学会 Japanese Society for Immunology
Academic Degree
Field(Japanese) Field(English) University(Japanese) University(English) Method
修士(生命科学) 京都大学
博士(生命科学) 京都大学
researchmap URL
https://researchmap.jp/read0111171
Research Topics
(Japanese)
免疫細胞の分化・維持のニッチとなる微小環境の解析。生体内微小環境の構築異常と、癌および血液・造血器疾患との関わり。
(English)
Identification and functional analysis of the microenvironment essential for immune cell development and homeostasis
Overview of the research
(Japanese)
免疫細胞の分化・維持・遊走を支持する微小環境の仕組み(ストローマ細胞ネットワーク)を研究している。また、微小環境のネットワーク構造の異常と、癌および血液・造血器疾患との因果関係について研究し、疾患発症機序の解明を目指している。
(English)
Immune cell development and homeostasis require the optimal microenvironment in the primary and secondary lymphoid tissues. Through the identification and functional analysis of stromal cells that construct the microenvironment, I aim to understand where and how immune cells are generated and maintained.
Fields of research (key words)
Key words(Japanese) Key words(English)
細胞生物学 Cell biology
生化学 Biochemistry
微小環境 Microenvironment
細胞外マトリックス Extracellular matrix
細胞接着 Cell adhesion
ストローマ細胞 Stromal cell
免疫細胞の分化・維持・遊走 Development, maintenance, and migration of immune cells
骨髄 Bone marrow
血液・造血器疾患 Hematopoietic disorders
Cancer
Published Papers
Author Author(Japanese) Author(English) Title Title(Japanese) Title(English) Bibliography Bibliography(Japanese) Bibliography(English) Publication date Refereed paper Language Publishing type Disclose
Shizue Tani-Ichi, Keisuke Wagatsuma, Takahiro Hara, Guangwei Cui, Shinya Abe, Hitoshi Miyachi, Satsuki Kitano, Koichi Ikuta Shizue Tani-Ichi, Keisuke Wagatsuma, Takahiro Hara, Guangwei Cui, Shinya Abe, Hitoshi Miyachi, Satsuki Kitano, Koichi Ikuta Shizue Tani-Ichi, Keisuke Wagatsuma, Takahiro Hara, Guangwei Cui, Shinya Abe, Hitoshi Miyachi, Satsuki Kitano, Koichi Ikuta Innate-like CD27+CD45RBhigh γδ T Cells Require TCR Signaling for Homeostasis in Peripheral Lymphoid Organs. Innate-like CD27+CD45RBhigh γδ T Cells Require TCR Signaling for Homeostasis in Peripheral Lymphoid Organs. Innate-like CD27+CD45RBhigh γδ T Cells Require TCR Signaling for Homeostasis in Peripheral Lymphoid Organs. Journal of immunology (Baltimore, Md. : 1950), 204, 10, 2671-2684 Journal of immunology (Baltimore, Md. : 1950), 204, 10, 2671-2684 Journal of immunology (Baltimore, Md. : 1950), 204, 10, 2671-2684 2020/05/15 Refereed English Research paper(scientific journal) Disclose to all
Hisa Mukohira, Takahiro Hara, Shinya Abe, Shizue Tani-Ichi, Atsuko Sehara-Fujisawa, Takashi Nagasawa, Kazuyuki Tobe, Koichi Ikuta Hisa Mukohira, Takahiro Hara, Shinya Abe, Shizue Tani-Ichi, Atsuko Sehara-Fujisawa, Takashi Nagasawa, Kazuyuki Tobe, Koichi Ikuta Hisa Mukohira, Takahiro Hara, Shinya Abe, Shizue Tani-Ichi, Atsuko Sehara-Fujisawa, Takashi Nagasawa, Kazuyuki Tobe, Koichi Ikuta Mesenchymal stromal cells in bone marrow express adiponectin and are efficiently targeted by an adiponectin promoter-driven Cre transgene. Mesenchymal stromal cells in bone marrow express adiponectin and are efficiently targeted by an adiponectin promoter-driven Cre transgene. Mesenchymal stromal cells in bone marrow express adiponectin and are efficiently targeted by an adiponectin promoter-driven Cre transgene. International immunology, 31, 11, 729-742 International immunology, 31, 11, 729-742 International immunology, 31, 11, 729-742 2019/10/16 Refereed English Research paper(scientific journal) Disclose to all
Akihiro Shimba, Guangwei Cui, Shizue Tani-Ichi, Makoto Ogawa, Shinya Abe, Fumie Okazaki, Satsuki Kitano, Hitoshi Miyachi, Hisakata Yamada, Takahiro Hara, Yasunobu Yoshikai, Takashi Nagasawa, Günther Schütz, Koichi Ikuta Akihiro Shimba, Guangwei Cui, Shizue Tani-Ichi, Makoto Ogawa, Shinya Abe, Fumie Okazaki, Satsuki Kitano, Hitoshi Miyachi, Hisakata Yamada, Takahiro Hara, Yasunobu Yoshikai, Takashi Nagasawa, Günther Schütz, Koichi Ikuta Akihiro Shimba, Guangwei Cui, Shizue Tani-Ichi, Makoto Ogawa, Shinya Abe, Fumie Okazaki, Satsuki Kitano, Hitoshi Miyachi, Hisakata Yamada, Takahiro Hara, Yasunobu Yoshikai, Takashi Nagasawa, Günther Schütz, Koichi Ikuta Glucocorticoids Drive Diurnal Oscillations in T Cell Distribution and Responses by Inducing Interleukin-7 Receptor and CXCR4. Glucocorticoids Drive Diurnal Oscillations in T Cell Distribution and Responses by Inducing Interleukin-7 Receptor and CXCR4. Glucocorticoids Drive Diurnal Oscillations in T Cell Distribution and Responses by Inducing Interleukin-7 Receptor and CXCR4. Immunity, 48, 2, 286-298 Immunity, 48, 2, 286-298 Immunity, 48, 2, 286-298 2018/02/20 Refereed English Research paper(scientific journal) Disclose to all
(* Co-first author, # Corresponding author) Cordeiro Gomes A*, Hara T* #, Lim VY*, Herndler-Brandstetter D, Nevius E, Sugiyama T, Tani-Ichi S, Schlenner S, Richie E, Rodewald HR, Flavell RA, Nagasawa T, Ikuta K, Pereira JP # (* Co-first author, # Corresponding author) Cordeiro Gomes A*, Hara T* #, Lim VY*, Herndler-Brandstetter D, Nevius E, Sugiyama T, Tani-Ichi S, Schlenner S, Richie E, Rodewald HR, Flavell RA, Nagasawa T, Ikuta K, Pereira JP # (* Co-first author, # Corresponding author) Cordeiro Gomes A*, Hara T* #, Lim VY*, Herndler-Brandstetter D, Nevius E, Sugiyama T, Tani-Ichi S, Schlenner S, Richie E, Rodewald HR, Flavell RA, Nagasawa T, Ikuta K, Pereira JP # Hematopoietic Stem Cell Niches Produce Lineage-Instructive Signals to Control Multipotent Progenitor Differentiation. Hematopoietic Stem Cell Niches Produce Lineage-Instructive Signals to Control Multipotent Progenitor Differentiation. Hematopoietic Stem Cell Niches Produce Lineage-Instructive Signals to Control Multipotent Progenitor Differentiation. Immunity, 45, 6, 1219-1231 Immunity, 45, 6, 1219-1231 Immunity, 45, 6, 1219-1231 2016/12/20 Refereed English Research paper(scientific journal) Disclose to all
Kenta Shinoda, Kiyoshi Hirahara, Tomohisa Iinuma, Tomomi Ichikawa, Akane S Suzuki, Kaoru Sugaya, Damon J Tumes, Heizaburo Yamamoto, Takahiro Hara, Shizue Tani-Ichi, Koichi Ikuta, Yoshitaka Okamoto, Toshinori Nakayama Kenta Shinoda, Kiyoshi Hirahara, Tomohisa Iinuma, Tomomi Ichikawa, Akane S Suzuki, Kaoru Sugaya, Damon J Tumes, Heizaburo Yamamoto, Takahiro Hara, Shizue Tani-Ichi, Koichi Ikuta, Yoshitaka Okamoto, Toshinori Nakayama Kenta Shinoda, Kiyoshi Hirahara, Tomohisa Iinuma, Tomomi Ichikawa, Akane S Suzuki, Kaoru Sugaya, Damon J Tumes, Heizaburo Yamamoto, Takahiro Hara, Shizue Tani-Ichi, Koichi Ikuta, Yoshitaka Okamoto, Toshinori Nakayama Thy1+IL-7+ lymphatic endothelial cells in iBALT provide a survival niche for memory T-helper cells in allergic airway inflammation. Thy1+IL-7+ lymphatic endothelial cells in iBALT provide a survival niche for memory T-helper cells in allergic airway inflammation. Thy1+IL-7+ lymphatic endothelial cells in iBALT provide a survival niche for memory T-helper cells in allergic airway inflammation. Proceedings of the National Academy of Sciences of the United States of America, 113, 20, E2842-51-E2851 Proceedings of the National Academy of Sciences of the United States of America, 113, 20, E2842-51-E2851 Proceedings of the National Academy of Sciences of the United States of America, 113, 20, E2842-51-E2851 2016/05/17 Refereed English Research paper(scientific journal) Disclose to all
Akifumi Abe, Shizue Tani-ichi, Soichiro Shitara, Guangwei Cui, Hisataka Yamada, Hitoshi Miyachi, Satsuki Kitano, Takahiro Hara, Ryo Abe, Yasunobu Yoshikai, Koichi Ikuta Abe A, Tani-ichi S, Shitara S, Cui G, Yamada H, Miyachi H, Kitano S, Hara T, Abe R, Yoshikai Y, Ikuta K Akifumi Abe, Shizue Tani-ichi, Soichiro Shitara, Guangwei Cui, Hisataka Yamada, Hitoshi Miyachi, Satsuki Kitano, Takahiro Hara, Ryo Abe, Yasunobu Yoshikai, Koichi Ikuta An Enhancer of the IL-7 Receptor α-Chain Locus Controls IL-7 Receptor Expression and Maintenance of Peripheral T Cells. An Enhancer of the IL-7 Receptor α-Chain Locus Controls IL-7 Receptor Expression and Maintenance of Peripheral T Cells. An Enhancer of the IL-7 Receptor α-Chain Locus Controls IL-7 Receptor Expression and Maintenance of Peripheral T Cells. Journal of immunology (Baltimore, Md. : 1950), 195, 7, 3129-38 Journal of immunology (Baltimore, Md. : 1950), 195, 7, 3129-38 Journal of immunology (Baltimore, Md. : 1950), 195, 7, 3129-38 2015/10/01 Refereed English Research paper(scientific journal) Disclose to all
Keisuke Wagatsuma, Shizue Tani-ichi, Bingfei Liang, Soichiro Shitara, Ko Ishihara, Manabu Abe, Hitoshi Miyachi, Satsuki Kitano, Takahiro Hara, Masanobu Nanno, Hiromichi Ishikawa, Kenji Sakimura, Mitsuyoshi Nakao, Hiroshi Kimura, Koichi Ikuta Wagatsuma K, Tani-ichi S, Liang B, Shitara S, Ishihara K, Abe M, Miyachi H, Kitano S, Hara T, Nanno M, Ishikawa H, Sakimura K, Nakao M, Kimura H, Ikuta K Keisuke Wagatsuma, Shizue Tani-ichi, Bingfei Liang, Soichiro Shitara, Ko Ishihara, Manabu Abe, Hitoshi Miyachi, Satsuki Kitano, Takahiro Hara, Masanobu Nanno, Hiromichi Ishikawa, Kenji Sakimura, Mitsuyoshi Nakao, Hiroshi Kimura, Koichi Ikuta STAT5 Orchestrates Local Epigenetic Changes for Chromatin Accessibility and Rearrangements by Direct Binding to the TCRγ Locus. STAT5 Orchestrates Local Epigenetic Changes for Chromatin Accessibility and Rearrangements by Direct Binding to the TCRγ Locus. STAT5 Orchestrates Local Epigenetic Changes for Chromatin Accessibility and Rearrangements by Direct Binding to the TCRγ Locus. Journal of immunology (Baltimore, Md. : 1950), 195, 4, 1804-14 Journal of immunology (Baltimore, Md. : 1950), 195, 4, 1804-14 Journal of immunology (Baltimore, Md. : 1950), 195, 4, 1804-14 2015/08/15 Refereed English Research paper(scientific journal) Disclose to all
Guangwei Cui, Takahiro Hara, Szandor Simmons, Keisuke Wagatsuma, Akifumi Abe, Hitoshi Miyachi, Satsuki Kitano, Masaru Ishii, Shizue Tani-ichi, Koichi Ikuta Guangwei Cui, Takahiro Hara, Szandor Simmons, Keisuke Wagatsuma, Akifumi Abe, Hitoshi Miyachi, Satsuki Kitano, Masaru Ishii, Shizue Tani-ichi, Koichi Ikuta Guangwei Cui, Takahiro Hara, Szandor Simmons, Keisuke Wagatsuma, Akifumi Abe, Hitoshi Miyachi, Satsuki Kitano, Masaru Ishii, Shizue Tani-ichi, Koichi Ikuta Characterization of the IL-15 niche in primary and secondary lymphoid organs in vivo. Characterization of the IL-15 niche in primary and secondary lymphoid organs in vivo. Characterization of the IL-15 niche in primary and secondary lymphoid organs in vivo. Proceedings of the National Academy of Sciences of the United States of America, 111, 5, 1915-20 Proceedings of the National Academy of Sciences of the United States of America, 111, 5, 1915-20 Proceedings of the National Academy of Sciences of the United States of America, 111, 5, 1915-20 2014/02/04 Refereed English Research paper(scientific journal) Disclose to all
Motokazu Tsuneto, Ekaterina Kajikhina, Katharina Seiler, Andreas Reimer, Julia Tornack, Corinne Bouquet, Szandor Simmons, Marko Knoll, Ingrid Wolf, Koji Tokoyoda, Anja Hauser, Takahiro Hara, Shizue Tani-ichi, Koichi Ikuta, Joachim R. Gruen, Andreas Gruetzkau, Niklas Engels, Juergen Wienands, Yuki Yanagisawa, Kazuo Ohnishi, Fritz Melchers Motokazu Tsuneto, Ekaterina Kajikhina, Katharina Seiler, Andreas Reimer, Julia Tornack, Corinne Bouquet, Szandor Simmons, Marko Knoll, Ingrid Wolf, Koji Tokoyoda, Anja Hauser, Takahiro Hara, Shizue Tani-ichi, Koichi Ikuta, Joachim R. Gruen, Andreas Gruetzkau, Niklas Engels, Juergen Wienands, Yuki Yanagisawa, Kazuo Ohnishi, Fritz Melchers Motokazu Tsuneto, Ekaterina Kajikhina, Katharina Seiler, Andreas Reimer, Julia Tornack, Corinne Bouquet, Szandor Simmons, Marko Knoll, Ingrid Wolf, Koji Tokoyoda, Anja Hauser, Takahiro Hara, Shizue Tani-ichi, Koichi Ikuta, Joachim R. Gruen, Andreas Gruetzkau, Niklas Engels, Juergen Wienands, Yuki Yanagisawa, Kazuo Ohnishi, Fritz Melchers Environments of B cell development Environments of B cell development Environments of B cell development IMMUNOLOGY LETTERS, 157, 1-2, 60-63 IMMUNOLOGY LETTERS, 157, 1-2, 60-63 IMMUNOLOGY LETTERS, 157, 1-2, 60-63 2014/01 Refereed English Disclose to all
Motokazu Tsuneto, Koji Tokoyoda, Ekaterina Kajikhina, Anja E Hauser, Takahiro Hara, Shizue Tani-Ichi, Koichi Ikuta, Fritz Melchers Motokazu Tsuneto, Koji Tokoyoda, Ekaterina Kajikhina, Anja E Hauser, Takahiro Hara, Shizue Tani-Ichi, Koichi Ikuta, Fritz Melchers Motokazu Tsuneto, Koji Tokoyoda, Ekaterina Kajikhina, Anja E Hauser, Takahiro Hara, Shizue Tani-Ichi, Koichi Ikuta, Fritz Melchers B-cell progenitors and precursors change their microenvironment in fetal liver during early development. B-cell progenitors and precursors change their microenvironment in fetal liver during early development. B-cell progenitors and precursors change their microenvironment in fetal liver during early development. Stem cells (Dayton, Ohio), 31, 12, 2800-12 Stem cells (Dayton, Ohio), 31, 12, 2800-12 Stem cells (Dayton, Ohio), 31, 12, 2800-12 2013/12 Refereed English Research paper(scientific journal) Disclose to all
Asami Hanazawa, Koji Hayashizaki, Kenta Shinoda, Hideo Yagita, Ko Okumura, Max Löhning, Takahiro Hara, Shizue Tani-ichi, Koichi Ikuta, Beate Eckes, Andreas Radbruch, Koji Tokoyoda, Toshinori Nakayama Asami Hanazawa, Koji Hayashizaki, Kenta Shinoda, Hideo Yagita, Ko Okumura, Max Löhning, Takahiro Hara, Shizue Tani-ichi, Koichi Ikuta, Beate Eckes, Andreas Radbruch, Koji Tokoyoda, Toshinori Nakayama Asami Hanazawa, Koji Hayashizaki, Kenta Shinoda, Hideo Yagita, Ko Okumura, Max Löhning, Takahiro Hara, Shizue Tani-ichi, Koichi Ikuta, Beate Eckes, Andreas Radbruch, Koji Tokoyoda, Toshinori Nakayama CD49b-dependent establishment of T helper cell memory. CD49b-dependent establishment of T helper cell memory. CD49b-dependent establishment of T helper cell memory. Immunology and cell biology, 91, 8, 524-31 Immunology and cell biology, 91, 8, 524-31 Immunology and cell biology, 91, 8, 524-31 2013/09 Refereed English Research paper(scientific journal) Disclose to all
(* Contributed equally) Shitara S*, Hara T*, Liang B, Wagatsuma K, Zuklys S, Holländer GA, Nakase H, Chiba T, Tani-ichi S, Ikuta K. (* Contributed equally) Shitara S*, Hara T*, Liang B, Wagatsuma K, Zuklys S, Holländer GA, Nakase H, Chiba T, Tani-ichi S, Ikuta K. (* Contributed equally) Shitara S*, Hara T*, Liang B, Wagatsuma K, Zuklys S, Holländer GA, Nakase H, Chiba T, Tani-ichi S, Ikuta K. IL-7 produced by thymic epithelial cells plays a major role in the development of thymocytes and TCRγδ+ intraepithelial lymphocytes. IL-7 produced by thymic epithelial cells plays a major role in the development of thymocytes and TCRγδ+ intraepithelial lymphocytes. IL-7 produced by thymic epithelial cells plays a major role in the development of thymocytes and TCRγδ+ intraepithelial lymphocytes. Journal of immunology (Baltimore, Md. : 1950), 190, 12, 6173-9 Journal of immunology (Baltimore, Md. : 1950), 190, 12, 6173-9 Journal of immunology (Baltimore, Md. : 1950), 190, 12, 6173-9 2013/06/15 Refereed English Research paper(scientific journal) Disclose to all
Shizue Tani-ichi, Akihiro Shimba, Keisuke Wagatsuma, Hitoshi Miyachi, Satsuki Kitano, Kumiko Imai, Takahiro Hara, Koichi Ikuta Shizue Tani-ichi, Akihiro Shimba, Keisuke Wagatsuma, Hitoshi Miyachi, Satsuki Kitano, Kumiko Imai, Takahiro Hara, Koichi Ikuta Shizue Tani-ichi, Akihiro Shimba, Keisuke Wagatsuma, Hitoshi Miyachi, Satsuki Kitano, Kumiko Imai, Takahiro Hara, Koichi Ikuta Interleukin-7 receptor controls development and maturation of late stages of thymocyte subpopulations. Interleukin-7 receptor controls development and maturation of late stages of thymocyte subpopulations. Interleukin-7 receptor controls development and maturation of late stages of thymocyte subpopulations. Proceedings of the National Academy of Sciences of the United States of America, 110, 2, 612-7 Proceedings of the National Academy of Sciences of the United States of America, 110, 2, 612-7 Proceedings of the National Academy of Sciences of the United States of America, 110, 2, 612-7 2013/01/08 Refereed English Research paper(scientific journal) Disclose to all
Bingfei Liang, Takahiro Hara, Keisuke Wagatsuma, Jia Zhang, Kazushige Maki, Hitoshi Miyachi, Satsuki Kitano, Chihiro Yabe-Nishimura, Shizue Tani-Ichi, Koichi Ikuta Bingfei Liang, Takahiro Hara, Keisuke Wagatsuma, Jia Zhang, Kazushige Maki, Hitoshi Miyachi, Satsuki Kitano, Chihiro Yabe-Nishimura, Shizue Tani-Ichi, Koichi Ikuta Bingfei Liang, Takahiro Hara, Keisuke Wagatsuma, Jia Zhang, Kazushige Maki, Hitoshi Miyachi, Satsuki Kitano, Chihiro Yabe-Nishimura, Shizue Tani-Ichi, Koichi Ikuta Role of hepatocyte-derived IL-7 in maintenance of intrahepatic NKT cells and T cells and development of B cells in fetal liver. Role of hepatocyte-derived IL-7 in maintenance of intrahepatic NKT cells and T cells and development of B cells in fetal liver. Role of hepatocyte-derived IL-7 in maintenance of intrahepatic NKT cells and T cells and development of B cells in fetal liver. Journal of immunology (Baltimore, Md. : 1950), 189, 9, 4444-50 Journal of immunology (Baltimore, Md. : 1950), 189, 9, 4444-50 Journal of immunology (Baltimore, Md. : 1950), 189, 9, 4444-50 2012/11/01 Refereed English Research paper(scientific journal) Disclose to all
Takahiro Hara, Soichiro Shitara, Kumiko Imai, Hitoshi Miyachi, Satsuki Kitano, Hisayuki Yao, Shizue Tani-ichi, Koichi Ikuta Takahiro Hara, Soichiro Shitara, Kumiko Imai, Hitoshi Miyachi, Satsuki Kitano, Hisayuki Yao, Shizue Tani-ichi, Koichi Ikuta Takahiro Hara, Soichiro Shitara, Kumiko Imai, Hitoshi Miyachi, Satsuki Kitano, Hisayuki Yao, Shizue Tani-ichi, Koichi Ikuta Identification of IL-7-producing cells in primary and secondary lymphoid organs using IL-7-GFP knock-in mice. Identification of IL-7-producing cells in primary and secondary lymphoid organs using IL-7-GFP knock-in mice. Identification of IL-7-producing cells in primary and secondary lymphoid organs using IL-7-GFP knock-in mice. Journal of immunology (Baltimore, Md. : 1950), 189, 4, 1577-84 Journal of immunology (Baltimore, Md. : 1950), 189, 4, 1577-84 Journal of immunology (Baltimore, Md. : 1950), 189, 4, 1577-84 2012/08/15 Refereed English Research paper(scientific journal) Disclose to all
Takahiro Hara, Tomoya Katakai, Jong-Hwan Lee, Yukiko Nambu, Natsuki Nakajima-Nagata, Hiroyuki Gonda, Manabu Sugai, Akira Shimizu Takahiro Hara, Tomoya Katakai, Jong-Hwan Lee, Yukiko Nambu, Natsuki Nakajima-Nagata, Hiroyuki Gonda, Manabu Sugai, Akira Shimizu Takahiro Hara, Tomoya Katakai, Jong-Hwan Lee, Yukiko Nambu, Natsuki Nakajima-Nagata, Hiroyuki Gonda, Manabu Sugai, Akira Shimizu A transmembrane chemokine, CXC chemokine ligand 16, expressed by lymph node fibroblastic reticular cells has the potential to regulate T cell migration and adhesion. A transmembrane chemokine, CXC chemokine ligand 16, expressed by lymph node fibroblastic reticular cells has the potential to regulate T cell migration and adhesion. A transmembrane chemokine, CXC chemokine ligand 16, expressed by lymph node fibroblastic reticular cells has the potential to regulate T cell migration and adhesion. International immunology, 18, 2, 301-11 International immunology, 18, 2, 301-11 International immunology, 18, 2, 301-11 2006/02 Refereed English Research paper(scientific journal) Disclose to all
Jong-Hwan Lee, Tomoya Katakai, Takahiro Hara, Hiroyuki Gonda, Manabu Sugai, Akira Shimizu Jong-Hwan Lee, Tomoya Katakai, Takahiro Hara, Hiroyuki Gonda, Manabu Sugai, Akira Shimizu Jong-Hwan Lee, Tomoya Katakai, Takahiro Hara, Hiroyuki Gonda, Manabu Sugai, Akira Shimizu Roles of p-ERM and Rho-ROCK signaling in lymphocyte polarity and uropod formation. Roles of p-ERM and Rho-ROCK signaling in lymphocyte polarity and uropod formation. Roles of p-ERM and Rho-ROCK signaling in lymphocyte polarity and uropod formation. The Journal of cell biology, 167, 2, 327-37 The Journal of cell biology, 167, 2, 327-37 The Journal of cell biology, 167, 2, 327-37 2004/10/25 Refereed English Research paper(scientific journal) Disclose to all
Tomoya Katakai, Takahiro Hara, Manabu Sugai, Hiroyuki Gonda, Akira Shimizu Tomoya Katakai, Takahiro Hara, Manabu Sugai, Hiroyuki Gonda, Akira Shimizu Tomoya Katakai, Takahiro Hara, Manabu Sugai, Hiroyuki Gonda, Akira Shimizu Lymph node fibroblastic reticular cells construct the stromal reticulum via contact with lymphocytes. Lymph node fibroblastic reticular cells construct the stromal reticulum via contact with lymphocytes. Lymph node fibroblastic reticular cells construct the stromal reticulum via contact with lymphocytes. The Journal of experimental medicine, 200, 6, 783-95 The Journal of experimental medicine, 200, 6, 783-95 The Journal of experimental medicine, 200, 6, 783-95 2004/09/20 Refereed English Research paper(scientific journal) Disclose to all
Tomoya Katakai, Takahiro Hara, Jong-Hwan Lee, Hiroyuki Gonda, Manabu Sugai, Akira Shimizu Tomoya Katakai, Takahiro Hara, Jong-Hwan Lee, Hiroyuki Gonda, Manabu Sugai, Akira Shimizu Tomoya Katakai, Takahiro Hara, Jong-Hwan Lee, Hiroyuki Gonda, Manabu Sugai, Akira Shimizu A novel reticular stromal structure in lymph node cortex: an immuno-platform for interactions among dendritic cells, T cells and B cells. A novel reticular stromal structure in lymph node cortex: an immuno-platform for interactions among dendritic cells, T cells and B cells. A novel reticular stromal structure in lymph node cortex: an immuno-platform for interactions among dendritic cells, T cells and B cells. International immunology, 16, 8, 1133-42 International immunology, 16, 8, 1133-42 International immunology, 16, 8, 1133-42 2004/08 Refereed English Research paper(scientific journal) Disclose to all
Tomoya Katakai, Takahiro Hara, Manabu Sugai, Hiroyuki Gonda, Akira Shimizu Tomoya Katakai, Takahiro Hara, Manabu Sugai, Hiroyuki Gonda, Akira Shimizu Tomoya Katakai, Takahiro Hara, Manabu Sugai, Hiroyuki Gonda, Akira Shimizu Th1-biased tertiary lymphoid tissue supported by CXC chemokine ligand 13-producing stromal network in chronic lesions of autoimmune gastritis. Th1-biased tertiary lymphoid tissue supported by CXC chemokine ligand 13-producing stromal network in chronic lesions of autoimmune gastritis. Th1-biased tertiary lymphoid tissue supported by CXC chemokine ligand 13-producing stromal network in chronic lesions of autoimmune gastritis. Journal of immunology (Baltimore, Md. : 1950), 171, 8, 4359-68 Journal of immunology (Baltimore, Md. : 1950), 171, 8, 4359-68 Journal of immunology (Baltimore, Md. : 1950), 171, 8, 4359-68 2003/10/15 Refereed English Research paper(scientific journal) Disclose to all
Tomoya Katakai, Takahiro Hara, Manabu Sugai, Hiroyuki Gonda, Yukiko Nambu, Eishou Matsuda, Yasutoshi Agata, Akira Shimizu Tomoya Katakai, Takahiro Hara, Manabu Sugai, Hiroyuki Gonda, Yukiko Nambu, Eishou Matsuda, Yasutoshi Agata, Akira Shimizu Tomoya Katakai, Takahiro Hara, Manabu Sugai, Hiroyuki Gonda, Yukiko Nambu, Eishou Matsuda, Yasutoshi Agata, Akira Shimizu Chemokine-independent preference for T-helper-1 cells in transendothelial migration. Chemokine-independent preference for T-helper-1 cells in transendothelial migration. Chemokine-independent preference for T-helper-1 cells in transendothelial migration. The Journal of biological chemistry, 277, 52, 50948-58 The Journal of biological chemistry, 277, 52, 50948-58 The Journal of biological chemistry, 277, 52, 50948-58 2002/12/27 Refereed English Research paper(scientific journal) Disclose to all

  • <<
  • >>
Title language:
Conference Activities & Talks
Title Title(Japanese) Title(English) Conference Conference(Japanese) Conference(English) Promotor Promotor(Japanese) Promotor(English) Date Language Assortment Disclose
Identification of bone marrow IL-7 niche critical for B lymphopoiesis Identification of bone marrow IL-7 niche critical for B lymphopoiesis The 7th International Workshop of Kyoto T Cell Conference, Kyoto The 7th International Workshop of Kyoto T Cell Conference, Kyoto 2017/03/15 English Disclose to all
Identification and characterization of IL-7 niche in vivo Identification and characterization of IL-7 niche in vivo Identification and characterization of IL-7 niche in vivo The 11th International Symposium of the Institute Network, Tokushima The 11th International Symposium of the Institute Network, Tokushima The 11th International Symposium of the Institute Network, Tokushima 2017/01/26 Disclose to all
Identification of IL-15 niche for NK cells in bone marrow Identification of IL-15 niche for NK cells in bone marrow Identification of IL-15 niche for NK cells in bone marrow 第45回日本免疫学会学術集会、宜野湾 第45回日本免疫学会学術集会、宜野湾 2016/12/07 Disclose to all
腸管関連リンパ組織におけるIL-7 ニッチの同定と特徴 腸管関連リンパ組織におけるIL-7 ニッチの同定と特徴 腸管関連リンパ組織におけるIL-7 ニッチの同定と特徴 BMB2015 第38回日本分子生物学会年会、第88回日本生化学会大会 合同大会 BMB2015 2015/12/01 Disclose to all
Identification of IL-7 and IL-15 niche in lymphoid organs[Invited] Identification of IL-7 and IL-15 niche in lymphoid organs [Invited] Identification of IL-7 and IL-15 niche in lymphoid organs [Invited] The 56th Annual Meeting and International Symposium of Korean Society of Life Science The 56th Annual Meeting and International Symposium of Korean Society of Life Science The 56th Annual Meeting and International Symposium of Korean Society of Life Science 2015/08/27 English Oral presentation(invited, special) Disclose to all
Differential roles of J promoters and E enhancers in controlling chromatin accessibility of the TCR locus by STAT5. Differential roles of J promoters and E enhancers in controlling chromatin accessibility of the TCR locus by STAT5. Differential roles of J promoters and E enhancers in controlling chromatin accessibility of the TCR locus by STAT5. The 6th International Workshop of Kyoto T Cell Conference 2013 The 6th International Workshop of Kyoto T Cell Conference 2013 2013/06/13 Disclose to all
Visualization and characterization of IL-7- and IL-15-expressing cells in vivo Visualization and characterization of IL-7- and IL-15-expressing cells in vivo Visualization and characterization of IL-7- and IL-15-expressing cells in vivo The 6th International Workshop of KTCC, Kyoto The 6th International Workshop of Kyoto T Cell Conference The 6th International Workshop of KTCC, Kyoto 2013/06/04 English Disclose to all
Interleukin-7 produced by thymic epithelial cells controls development and maturation of thymocytes Interleukin-7 produced by thymic epithelial cells controls development and maturation of thymocytes Interleukin-7 produced by thymic epithelial cells controls development and maturation of thymocytes 第41 回日本免疫学会学術集会、神戸、2012 年12 月6 日 第41 回日本免疫学会学術集会、神戸、2012 年12 月6 日 第41 回日本免疫学会学術集会、神戸、2012 年12 月6 日 2012 English Disclose to all
Visualization and characterization of IL-15-expressing cells in vivo by IL-15-CFP knock-in mice Visualization and characterization of IL-15-expressing cells in vivo by IL-15-CFP knock-in mice Visualization and characterization of IL-15-expressing cells in vivo by IL-15-CFP knock-in mice 第41 回日本免疫学会学術集会、神戸、2012 年12 月5 日 第41 回日本免疫学会学術集会、神戸、2012 年12 月5 日 第41 回日本免疫学会学術集会、神戸、2012 年12 月5 日 2012 English Disclose to all
リンパ管内皮細胞が産生するIL-7 は末梢T 細胞の組織分布を制御する リンパ管内皮細胞が産生するIL-7 は末梢T 細胞の組織分布を制御する 第40回日本免疫学会学術集会、千葉 第40回日本免疫学会学術集会、千葉 2011/11/28 Japanese Disclose to all
小腸上皮内γδT 細胞は胸腺に由来する 小腸上皮内γδT 細胞は胸腺に由来する 第21 回Kyoto T Cell Conference 、京都、2011 年6 月11 日 第21 回Kyoto T Cell Conference 、京都、2011 年6 月11 日 2011 Japanese Disclose to all
肝細胞が産生するIL-7 は肝臓でのリンパ球の分化と維持を制御する 肝細胞が産生するIL-7 は肝臓でのリンパ球の分化と維持を制御する 第40 回日本免疫学会学術集会、千葉、 2011 年11 月28 日 第40 回日本免疫学会学術集会、千葉、 2011 年11 月28 日 2011 Japanese Disclose to all
IL-7 産生細胞の体内分布と局所機能 IL-7 産生細胞の体内分布と局所機能 第20 回Kyoto T Cell Conference 、京都,6 月4 日,20 10. 第20 回Kyoto T Cell Conference 、京都,6 月4 日,20 10. 2010 Japanese Disclose to all
Distribution and function of IL-7-producing stromal cells. Distribution and function of IL-7-producing stromal cells. Distribution and function of IL-7-producing stromal cells. the 5th International Workshop of Kyoto T Cell Conference, Kyoto, June 3, 2009・ the 5th International Workshop of Kyoto T Cell Conference, Kyoto, June 3, 2009・ the 5th International Workshop of Kyoto T Cell Conference, Kyoto, June 3, 2009・ 2009 English Disclose to all
胸線上皮細胞が産生するIL-7 の局所的役割 胸線上皮細胞が産生するIL-7 の局所的役割 第 39 回日本免疫学会学術集会、大阪、12 月2 日、2009. 第 39 回日本免疫学会学術集会、大阪、12 月2 日、2009. 2009 Japanese Disclose to all
IL-7 産生ストローマ細胞のリンパ組織内分布 IL-7 産生ストローマ細胞のリンパ組織内分布 第39 回日本免疫学会学術集会、大阪、12 月3 日、2009. 第39 回日本免疫学会学術集会、大阪、12 月3 日、2009. 2009 Japanese Disclose to all
リンパ節由来細網線維芽細胞の細網ネットワーク構築におけるリンフォトキシンシグナル経路の関与 リンパ節由来細網線維芽細胞の細網ネットワーク構築におけるリンフォトキシンシグナル経路の関与 リンパ節由来細網線維芽細胞の細網ネットワーク構築におけるリンフォトキシンシグナル経路の関与 日本免疫学会総会・学術集会記録 日本免疫学会総会・学術集会記録 日本免疫学会総会・学術集会記録 (NPO)日本免疫学会 (NPO)日本免疫学会 2004/11 Japanese Disclose to all
リンパ節細網線維芽細胞が発現するケモカインCXCL16を介したリンパ球の動態制御 リンパ節細網線維芽細胞が発現するケモカインCXCL16を介したリンパ球の動態制御 リンパ節細網線維芽細胞が発現するケモカインCXCL16を介したリンパ球の動態制御 日本免疫学会総会・学術集会記録 日本免疫学会総会・学術集会記録 日本免疫学会総会・学術集会記録 (NPO)日本免疫学会 (NPO)日本免疫学会 2004/11 Japanese Disclose to all
リンパ節細網線維芽細胞は免疫系細胞との接触により細網構造を構築し,「免疫プラットホーム」を提供する リンパ節細網線維芽細胞は免疫系細胞との接触により細網構造を構築し,「免疫プラットホーム」を提供する リンパ節細網線維芽細胞は免疫系細胞との接触により細網構造を構築し,「免疫プラットホーム」を提供する 日本免疫学会総会・学術集会記録 日本免疫学会総会・学術集会記録 日本免疫学会総会・学術集会記録 (NPO)日本免疫学会 (NPO)日本免疫学会 2003/11 Japanese Disclose to all
二次リンパ組織において免疫反応の場を提供する細網線維芽細胞(FRC) 二次リンパ組織において免疫反応の場を提供する細網線維芽細胞(FRC) 二次リンパ組織において免疫反応の場を提供する細網線維芽細胞(FRC) 日本免疫学会総会・学術集会記録 日本免疫学会総会・学術集会記録 日本免疫学会総会・学術集会記録 2001/10/31 Japanese Disclose to all

  • <<
  • >>
Title language:
Books etc
Author Author(Japanese) Author(English) Title Title(Japanese) Title(English) Publisher Publisher(Japanese) Publisher(English) Publication date Language Type Disclose
原 崇裕 原 崇裕 多能造血前駆細胞からリンパ球までの分化を方向付ける骨髄IL-7ニッチの同定 多能造血前駆細胞からリンパ球までの分化を方向付ける骨髄IL-7ニッチの同定 医学のあゆみ 医学のあゆみ 2017/06 Single Work Disclose to all
生田宏一, 崔 広為, 原 崇裕 生田宏一, 崔 広為, 原 崇裕 生体内リンパ器官におけるサイトカインニッチの解明 生体内リンパ器官におけるサイトカインニッチの解明 感染・炎症・免疫 感染・炎症・免疫 2015 Joint Work Disclose to all
谷一靖江, 原 崇裕, 生田宏一 谷一靖江, 原 崇裕, 生田宏一 T細胞における IL-7レセプターの転写制御と機能 T細胞における IL-7レセプターの転写制御と機能 臨床免疫・アレルギー科 臨床免疫・アレルギー科 2014 Disclose to all
生田宏一, 原 崇裕, 谷一靖江 生田宏一, 原 崇裕, 谷一靖江 肝臓IL-7 の新たな機能 肝臓IL-7 の新たな機能 感染・炎症・免疫 感染・炎症・免疫 2013 Joint Work Disclose to all
原 崇裕, 生田 宏一 原 崇裕, 生田 宏一 IL-7産生細胞のリンパ組織内分布 IL-7産生細胞のリンパ組織内分布 医学のあゆみ 医学のあゆみ 2013 Joint Work Disclose to all
生田 宏一, 原 崇裕, 谷一 靖江 生田 宏一, 原 崇裕, 谷一 靖江 胸腺上皮細胞が産生するサイトカインとT細胞の分化 (特集 胸腺におけるT細胞の分化とその機序) 胸腺上皮細胞が産生するサイトカインとT細胞の分化 (特集 胸腺におけるT細胞の分化とその機序) 臨床免疫・アレルギー科 臨床免疫・アレルギー科 2011 Disclose to all
原 崇裕, 片貝智哉, 清水 章 原 崇裕, 片貝智哉, 清水 章 リンパ節細網線維芽細胞によるT細胞の動態制御 リンパ節細網線維芽細胞によるT細胞の動態制御 臨床免疫 臨床免疫 2006 Disclose to all
Title language:
Awards
Title(Japanese) Title(English) Organization name(Japanese) Organization name(English) Date
BioLegend/ Tomy Digital Biology 若手研究者 Research Award 2013
External funds: competitive funds and Grants-in-Aid for Scientific Research (Kakenhi)
Type Position Title(Japanese) Title(English) Period
基盤研究(C) Representative 自然免疫系を構築する骨微小環境の新規同定(2020年度分) 2019/04/01-2020/03/31
基盤研究(C) Representative 自然免疫系を構築する骨微小環境の新規同定(2019年度分) 2019/04/01-2020/03/31
基盤研究(C) Representative 自然免疫系を構築する骨微小環境の新規同定 2019/04/01-2022/03/31
基盤研究(C) Representative 2型自然リンパ球の分化・機能獲得を制御する免疫微小環境の解明 (平成30年度分) 2018/04/01-2019/03/31
基盤研究(C) Representative 2型自然リンパ球の分化・機能獲得を制御する免疫微小環境の解明 (平成29年度分) 2017/04/01-2018/03/31
基盤研究(C) Representative 2型自然リンパ球の分化・機能獲得を制御する免疫微小環境の解明 (平成28年度分) 2016/04/01-2017/03/31
基盤研究(C) Representative 2型自然リンパ球の分化・機能獲得を制御する免疫微小環境の解明 2016/04/01-2019/03/31
若手研究(B) Representative IL-7産生ストローマ細胞が形成する骨髄微小環境の機能解明 2014/04/01-2016/03/31
若手研究(B) Representative 内皮細胞由来IL-7によるB細胞分化、末梢T細胞維持の機構 2012/04/01-2014/03/31
基盤研究(C) Assignment IL-15産生細胞の生体内における分布と機能 2013/04/01-2016/03/31
基盤研究(C) Assignment IL-7産生細胞の生体内における分布と機能 2020/04/01-2021/03/31

  • <<
  • >>
External funds: other than those above
System Main person Title(Japanese) Title(English) Period
一般財団法人 清水免疫学・神経科学振興財団 助成金 原 崇裕 自然免疫系を構築する骨微小環境の新規同定 2019-
一般財団法人 清水免疫学・神経科学振興財団 助成金 原 崇裕 IL-7産生ストローマ細胞が形成する骨髄微小環境の機能解明 2015-
藤原記念財団 奨励金  原 崇裕 2014-
BioLegend/ Tomy Digital Biology 若手研究者 Research Award 2013 原 崇裕 2013-
Teaching subject(s)
Name(Japanese) Name(English) Term Department Period
生命科学研究の第一線に立つI The Front Line of Life Science Research I 前期 全学共通科目 2012/04-2013/03
生命科学研究の第一線に立つI The Front Line of Life Science Research I 前期 全学共通科目 2013/04-2014/03
生命科学研究の第一線に立つII The Front Line of Life Science Research II 前期 全学共通科目 2014/04-2015/03
生命科学研究の第一線に立つII The Front Line of Life Science Research II 前期 全学共通科目 2015/04-2016/03
ウイルスと生命科学の最前線 前期 全学共通科目 2016/04/-2019/03/
生命科学(医学・生物学)研究の最前線 The Frontiers in Life Science (Medical and Biological Science) Research 前期 全学共通科目 2019/04/-2020/03/
Part-time lecturer (outside KU)
Cource name(Japanese) Cource name(English) Term University Department Period
免疫と生体防御 福井大学 医学部 2016/04/-2019/03/
免疫と生体防御 福井大学 医学部 2019/04/01-2021/03/31
Faculty management (title, position)
Title Period
化学物質管理委員会 委員 2013/04/01-2015/03/31
化学物質管理委員会 委員 2016/10/01-
Other activities (primary and secondary education)
Title Activity School Prefecture Date
研究室体験講座 訪問受け入れ 京都府立南陽高等学校 京都府