山門 穂高

Last Update: 2019/06/03 14:18:03

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Name(Kanji/Kana/Abecedarium Latinum)
山門 穂高/ヤマカド ホダカ/Yamakado, Hodaka
Primary Affiliation(Org1/Job title)
Kyoto University Hospital/Program-Specific Associate Professor
Contact Address
Type Address(Japanese) Address(English)
Office 京都市左京区聖護院川原町５４　京都大学医学部付属病院神経内科
Phone
Type Number
Office 075-751-3767
Academic Organizations You are Affiliated to in Japan
Organization name(Japanese) Organization name(English)
日本神経学会 Japanese society of neurology
日本内科学会 Japanese Society of Internal Medicine
Academic Organizations Overaseas You are Affiliated to
Organization name Country
Society For Neuroscience 米国
International Parkinson and Movement Disorder Society
Academic Degree
Field(Japanese) Field(English) University(Japanese) University(English) Method
博士（医学） 京都大学
Graduate School
University(Japanese) University(English) Faculty(Japanese) Faculty(English) Major(Japanese) Major(English) Degree
京都大学 大学院医学研究科博士課程脳統御医科学専攻 修了
Undergraduate School / Major(s)
University(Japanese) University(English) Faculty(Japanese) Faculty(English) Major(s)(Japanese) Major(s)(English) Degree
京都大学 医学部医学科 卒業
High School
Highschool Kana
三重高田高等学校 みえたかだこうとうがっこう
Work Experience
Period Organization(Japanese) Organization(English) Job title(Japanese) Job title(English)
2000/4-2003/3 虎の門病院　内科 Department of Internal Medicine, Toranomon Hospital 研修医 Resident
2003/4-2005/3 京都大学医学部付属病院　神経内科 Department of Neurology, Kyoto University Hospital 医員 Clinical fellow
2009/4-2010/9 京都大学医学部付属病院　神経内科 Department of Neurology, Kyoto University Hospital 助教 Assistant professor
2010/10/-2011/3 武田総合病院　神経内科 Department of Neurology, Takeda General Hospital 医長 Clinical fellow
2011/4-2019/03/31 京都大学医学部付属病院　神経内科 Department of Neurology, Kyoto University Hospital 助教 Assistant professor
2019/04/01- 京都大学医学部附属病院　脳神経内科 Department of Neurology Kyoto University Hospital 特定准教授 Project Associate Professor
Personal Profile
(Japanese)
研究においては、様々なモデル動物を用いたパーキンソン病・多系統委縮症の病態解析・治療法開発、臨床においては京都大学病院においてパーキンソン病を中心とした神経内科の一般診療を行っている。
(English)
My research interest is focused on the pathomechanism of Parkinson's disease (PD) / multiple system atrophy (MSA) and development of novel therapeutics for PD/MSA. Also, I am working as a general neurologist at Kyoto University Hospital .　
Research Topics
(Japanese)
神経変性疾患の分子生物学的研究
(English)
Molecular biology of neurodegenerative disorders
Overview of the research
(Japanese)
神経変性疾患、特にパーキンソン病（Parkinson's disease, PD)や多系統萎縮症において、様々なモデル動物（マウス、ラット、メダカ）やiPS細胞を用いてモデル動物の開発、病態メカニズムの解明、新規治療法の開発を目指した研究を行っている。特にα-synucleinやglucocerebrosidase (GBA)といった孤発性PDに深く関与する分子を中心とした研究を行っている。
(English)
My research is fosused on the development of model for Parkinson's disease and multiple system atrophy using mice, rat, medaka fish and patients-derived iPS cells as well as investigation of pathomechanisms underlying PD and development of novel therapeutics for PD.
Fields of research (key words)
Key words(Japanese) Key words(English)
神経内科学 Neurology
Published Papers
Author Author(Japanese) Author(English) Title Title(Japanese) Title(English) Bibliography Bibliography(Japanese) Bibliography(English) Publication date Refereed paper Language Publishing type Disclose
Ikuno M, Yamakado H, Akiyama H, Parajuli LK, Taguchi K, Hara J, Uemura N, Hatanaka Y, Higaki K, Ohno K, Tanaka M, Koike M, Hirabayashi Y, Takahashi R Ikuno M, Yamakado H, Akiyama H, Parajuli LK, Taguchi K, Hara J, Uemura N, Hatanaka Y, Higaki K, Ohno K, Tanaka M, Koike M, Hirabayashi Y, Takahashi R Ikuno M, Yamakado H, Akiyama H, Parajuli LK, Taguchi K, Hara J, Uemura N, Hatanaka Y, Higaki K, Ohno K, Tanaka M, Koike M, Hirabayashi Y, Takahashi R GBA haploinsufficiency accelerates alpha synuclein pathology with altered lipid metabolism in a prodromal model of Parkinson's disease=. GBA haploinsufficiency accelerates alpha synuclein pathology with altered lipid metabolism in a prodromal model of Parkinson's disease=. GBA haploinsufficiency accelerates alpha synuclein pathology with altered lipid metabolism in a prodromal model of Parkinson's disease=. Human molecular genetics Human molecular genetics Human molecular genetics 2019/01 Refereed Disclose to all
Tojima M, Murakami G, Hikawa R, Yamakado H, Yamashita H, Takahashi R, Matsui M Tojima M, Murakami G, Hikawa R, Yamakado H, Yamashita H, Takahashi R, Matsui M Tojima M, Murakami G, Hikawa R, Yamakado H, Yamashita H, Takahashi R, Matsui M Homozygous 31 trinucleotide repeats in the SCA2 allele are pathogenic for cerebellar ataxia. Homozygous 31 trinucleotide repeats in the SCA2 allele are pathogenic for cerebellar ataxia. Homozygous 31 trinucleotide repeats in the SCA2 allele are pathogenic for cerebellar ataxia. Neurology. Genetics, 4, 6, e283 Neurology. Genetics, 4, 6, e283 Neurology. Genetics, 4, 6, e283 2018/12 Refereed Disclose to all
Sakamoto A, Arai R, Okamoto T, Yamada Y, Yamakado H, Matsuda S Sakamoto A, Arai R, Okamoto T, Yamada Y, Yamakado H, Matsuda S Sakamoto A, Arai R, Okamoto T, Yamada Y, Yamakado H, Matsuda S Ischemic Fasciitis of the Left Buttock in a 40-Year-Old Woman with Beta-Propeller Protein-Associated Neurodegeneration (BPAN). Ischemic Fasciitis of the Left Buttock in a 40-Year-Old Woman with Beta-Propeller Protein-Associated Neurodegeneration (BPAN). Ischemic Fasciitis of the Left Buttock in a 40-Year-Old Woman with Beta-Propeller Protein-Associated Neurodegeneration (BPAN). The American journal of case reports, 19, 1249-1252 The American journal of case reports, 19, 1249-1252 The American journal of case reports, 19, 1249-1252 2018/10 Refereed Disclose to all
Kim C, Spencer B, Rockenstein E, Yamakado H, Mante M, Adame A, Fields JA, Masliah D, Iba M, Lee HJ, Rissman RA, Lee SJ, Masliah E Kim C, Spencer B, Rockenstein E, Yamakado H, Mante M, Adame A, Fields JA, Masliah D, Iba M, Lee HJ, Rissman RA, Lee SJ, Masliah E Kim C, Spencer B, Rockenstein E, Yamakado H, Mante M, Adame A, Fields JA, Masliah D, Iba M, Lee HJ, Rissman RA, Lee SJ, Masliah E Immunotherapy targeting toll-like receptor 2 alleviates neurodegeneration in models of synucleinopathy by modulating α-synuclein transmission and neuroinflammation. Immunotherapy targeting toll-like receptor 2 alleviates neurodegeneration in models of synucleinopathy by modulating α-synuclein transmission and neuroinflammation. Immunotherapy targeting toll-like receptor 2 alleviates neurodegeneration in models of synucleinopathy by modulating α-synuclein transmission and neuroinflammation. Molecular neurodegeneration, 13, 1, 43 Molecular neurodegeneration, 13, 1, 43 Molecular neurodegeneration, 13, 1, 43 2018/08 Refereed Disclose to all
Fujita K, Homma H, Kondo K, Ikuno M, Yamakado H, Tagawa K, Murayama S, Takahashi R, Okazawa H Fujita K, Homma H, Kondo K, Ikuno M, Yamakado H, Tagawa K, Murayama S, Takahashi R, Okazawa H Fujita K, Homma H, Kondo K, Ikuno M, Yamakado H, Tagawa K, Murayama S, Takahashi R, Okazawa H Ser46-Phosphorylated MARCKS Is a Marker of Neurite Degeneration at the Pre-aggregation Stage in PD/DLB Pathology. Ser46-Phosphorylated MARCKS Is a Marker of Neurite Degeneration at the Pre-aggregation Stage in PD/DLB Pathology. Ser46-Phosphorylated MARCKS Is a Marker of Neurite Degeneration at the Pre-aggregation Stage in PD/DLB Pathology. eNeuro, 5, 4 eNeuro, 5, 4 eNeuro, 5, 4 2018/07 Refereed Disclose to all
Uemura N, Yagi H, Uemura MT, Hatanaka Y, Yamakado H, Takahashi R Uemura N, Yagi H, Uemura MT, Hatanaka Y, Yamakado H, Takahashi R Uemura N, Yagi H, Uemura MT, Hatanaka Y, Yamakado H, Takahashi R Inoculation of α-synuclein preformed fibrils into the mouse gastrointestinal tract induces Lewy body-like aggregates in the brainstem via the vagus nerve. Inoculation of α-synuclein preformed fibrils into the mouse gastrointestinal tract induces Lewy body-like aggregates in the brainstem via the vagus nerve. Inoculation of α-synuclein preformed fibrils into the mouse gastrointestinal tract induces Lewy body-like aggregates in the brainstem via the vagus nerve. Molecular neurodegeneration, 13, 1, 21 Molecular neurodegeneration, 13, 1, 21 Molecular neurodegeneration, 13, 1, 21 2018/05 Refereed Disclose to all
Hikiami R, Yamakado H, Tatsumi S, Ayaki T, Hashi Y, Yamashita H, Sawamoto N, Tsuji T, Urushitani M, Takahashi R Hikiami R, Yamakado H, Tatsumi S, Ayaki T, Hashi Y, Yamashita H, Sawamoto N, Tsuji T, Urushitani M, Takahashi R Hikiami R, Yamakado H, Tatsumi S, Ayaki T, Hashi Y, Yamashita H, Sawamoto N, Tsuji T, Urushitani M, Takahashi R Amyotrophic Lateral Sclerosis after Receiving the Human Papilloma Virus Vaccine: A Case Report of a 15-year-old Girl. Amyotrophic Lateral Sclerosis after Receiving the Human Papilloma Virus Vaccine: A Case Report of a 15-year-old Girl. Amyotrophic Lateral Sclerosis after Receiving the Human Papilloma Virus Vaccine: A Case Report of a 15-year-old Girl. Internal medicine (Tokyo, Japan), 57, 13, 1917-1919 Internal medicine (Tokyo, Japan), 57, 13, 1917-1919 Internal medicine (Tokyo, Japan), 57, 13, 1917-1919 2018/02 Refereed Disclose to all
Ihse E, Yamakado H, van Wijk XM, Lawrence R, Esko JD, Masliah E Ihse E, Yamakado H, van Wijk XM, Lawrence R, Esko JD, Masliah E Ihse E, Yamakado H, van Wijk XM, Lawrence R, Esko JD, Masliah E Cellular internalization of alpha-synuclein aggregates by cell surface heparan sulfate depends on aggregate conformation and cell type. Cellular internalization of alpha-synuclein aggregates by cell surface heparan sulfate depends on aggregate conformation and cell type. Cellular internalization of alpha-synuclein aggregates by cell surface heparan sulfate depends on aggregate conformation and cell type. Scientific reports, 7, 1, 9008 Scientific reports, 7, 1, 9008 Scientific reports, 7, 1, 9008 2017/08 Refereed Disclose to all
Saito N, Takahata K, Yamakado H, Sawamoto N, Saito S, Takahashi R, Murai T, Takahashi H Saito N, Takahata K, Yamakado H, Sawamoto N, Saito S, Takahashi R, Murai T, Takahashi H Saito N, Takahata K, Yamakado H, Sawamoto N, Saito S, Takahashi R, Murai T, Takahashi H Altered awareness of action in Parkinson's disease: evaluations by explicit and implicit measures. Altered awareness of action in Parkinson's disease: evaluations by explicit and implicit measures. Altered awareness of action in Parkinson's disease: evaluations by explicit and implicit measures. Scientific reports, 7, 1, 8019 Scientific reports, 7, 1, 8019 Scientific reports, 7, 1, 8019 2017/08 Refereed Disclose to all
Uemura MT, Asano T, Hikawa R, Yamakado H, Takahashi R Uemura MT, Asano T, Hikawa R, Yamakado H, Takahashi R Uemura MT, Asano T, Hikawa R, Yamakado H, Takahashi R Zonisamide inhibits monoamine oxidase and enhances motor performance and social activity. Zonisamide inhibits monoamine oxidase and enhances motor performance and social activity. Zonisamide inhibits monoamine oxidase and enhances motor performance and social activity. Neuroscience research, 124, 25-32 Neuroscience research, 124, 25-32 Neuroscience research, 124, 25-32 2017/06 Refereed Disclose to all
Kikuchi T, Morizane A, Doi D, Okita K, Nakagawa M, Yamakado H, Inoue H, Takahashi R, Takahashi J Kikuchi T, Morizane A, Doi D, Okita K, Nakagawa M, Yamakado H, Inoue H, Takahashi R, Takahashi J Kikuchi T, Morizane A, Doi D, Okita K, Nakagawa M, Yamakado H, Inoue H, Takahashi R, Takahashi J Idiopathic Parkinson's disease patient-derived induced pluripotent stem cells function as midbrain dopaminergic neurons in rodent brains. Idiopathic Parkinson's disease patient-derived induced pluripotent stem cells function as midbrain dopaminergic neurons in rodent brains. Idiopathic Parkinson's disease patient-derived induced pluripotent stem cells function as midbrain dopaminergic neurons in rodent brains. Journal of neuroscience research, 95, 9, 1829-1837 Journal of neuroscience research, 95, 9, 1829-1837 Journal of neuroscience research, 95, 9, 1829-1837 2017/02 Refereed Disclose to all
Kinoshita H, Yamakado H, Kitano T, Kitamura A, Yamashita H, Miyamoto M, Hitomi T, Okada T, Nakamoto Y, Sawamoto N, Takaori-Kondo A, Takahashi R Kinoshita H, Yamakado H, Kitano T, Kitamura A, Yamashita H, Miyamoto M, Hitomi T, Okada T, Nakamoto Y, Sawamoto N, Takaori-Kondo A, Takahashi R Kinoshita H, Yamakado H, Kitano T, Kitamura A, Yamashita H, Miyamoto M, Hitomi T, Okada T, Nakamoto Y, Sawamoto N, Takaori-Kondo A, Takahashi R Diagnostic utility of FDG-PET in neurolymphomatosis: report of five cases. Diagnostic utility of FDG-PET in neurolymphomatosis: report of five cases. Diagnostic utility of FDG-PET in neurolymphomatosis: report of five cases. Journal of neurology, 263, 9, 1719-1726 Journal of neurology, 263, 9, 1719-1726 Journal of neurology, 263, 9, 1719-1726 2016/06 Refereed Disclose to all
Hamatani M, Jingami N, Uemura K, Nakasone N, Kinoshita H, Yamakado H, Ninomiya H, Takahashi R Hamatani M, Jingami N, Uemura K, Nakasone N, Kinoshita H, Yamakado H, Ninomiya H, Takahashi R Hamatani M, Jingami N, Uemura K, Nakasone N, Kinoshita H, Yamakado H, Ninomiya H, Takahashi R A case of variant biochemical phenotype of Niemann-Pick disease type C accompanying savant syndrome. A case of variant biochemical phenotype of Niemann-Pick disease type C accompanying savant syndrome. A case of variant biochemical phenotype of Niemann-Pick disease type C accompanying savant syndrome. Rinsho shinkeigaku = Clinical neurology, 56, 6, 424-429 Rinsho shinkeigaku = Clinical neurology, 56, 6, 424-429 Rinsho shinkeigaku = Clinical neurology, 56, 6, 424-429 2016/06 Refereed Disclose to all
Uemura N, Koike M, Ansai S, Kinoshita M, Ishikawa-Fujiwara T, Matsui H, Naruse K, Sakamoto N, Uchiyama Y, Todo T, Takeda S, Yamakado H, Takahashi R. Uemura N, Koike M, Ansai S, Kinoshita M, Ishikawa-Fujiwara T, Matsui H, Naruse K, Sakamoto N, Uchiyama Y, Todo T, Takeda S, Yamakado H, Takahashi R. Uemura N, Koike M, Ansai S, Kinoshita M, Ishikawa-Fujiwara T, Matsui H, Naruse K, Sakamoto N, Uchiyama Y, Todo T, Takeda S, Yamakado H, Takahashi R. Viable Neuronopathic Gaucher Disease Model in Medaka (Oryzias latipes) Displays Axonal Accumulation of Alpha-Synuclein. Viable Neuronopathic Gaucher Disease Model in Medaka (Oryzias latipes) Displays Axonal Accumulation of Alpha-Synuclein. Viable Neuronopathic Gaucher Disease Model in Medaka (Oryzias latipes) Displays Axonal Accumulation of Alpha-Synuclein. PLoS Genet, 11, 4, e1005065 PLoS Genet, 11, 4, e1005065 PLoS Genet, 11, 4, e1005065 2015/04 Refereed English Research paper(scientific journal) Disclose to all
Yamakado H Yamakado H Yamakado H Advance in PD research explored a new field on ubiquitin biology. Advance in PD research explored a new field on ubiquitin biology. Advance in PD research explored a new field on ubiquitin biology. Movement disorders : official journal of the Movement Disorder Society, 29, 10, 1243 Movement disorders : official journal of the Movement Disorder Society, 29, 10, 1243 Movement disorders : official journal of the Movement Disorder Society, 29, 10, 1243 2014/09 Refereed English Disclose to all
Tojima M, Hitomi T, Jingami N, Tanioka K, Yamakado H, Matsumoto R, Takahashi Y, Ikeda A, Takahashi R Tojima M, Hitomi T, Jingami N, Tanioka K, Yamakado H, Matsumoto R, Takahashi Y, Ikeda A, Takahashi R Tojima M, Hitomi T, Jingami N, Tanioka K, Yamakado H, Matsumoto R, Takahashi Y, Ikeda A, Takahashi R [Two cases of acute onset of focal cortical reflex myoclonus following acute aseptic meningoencephalitis with positive anti-glutamate receptor autoantibody]. [Two cases of acute onset of focal cortical reflex myoclonus following acute aseptic meningoencephalitis with positive anti-glutamate receptor autoantibody]. [Two cases of acute onset of focal cortical reflex myoclonus following acute aseptic meningoencephalitis with positive anti-glutamate receptor autoantibody]. Rinsho shinkeigaku = Clinical neurology, 54, 7, 543-549 Rinsho shinkeigaku = Clinical neurology, 54, 7, 543-549 Rinsho shinkeigaku = Clinical neurology, 54, 7, 543-549 2014 Refereed English Disclose to all
Matsui H, Uemura N, Yamakado H, Takeda S, Takahashi R Matsui H, Uemura N, Yamakado H, Takeda S, Takahashi R Matsui H, Uemura N, Yamakado H, Takeda S, Takahashi R Exploring the pathogenetic mechanisms underlying Parkinson's disease in medaka fish. Exploring the pathogenetic mechanisms underlying Parkinson's disease in medaka fish. Exploring the pathogenetic mechanisms underlying Parkinson's disease in medaka fish. Journal of Parkinson's disease, 4, 2, 301-310 Journal of Parkinson's disease, 4, 2, 301-310 Journal of Parkinson's disease, 4, 2, 301-310 2014 Refereed English Disclose to all
Yamakado H, Takahashi R Yamakado H, Takahashi R Yamakado H, Takahashi R The function of parkin: revisited. The function of parkin: revisited. The function of parkin: revisited. Movement disorders : official journal of the Movement Disorder Society, 28, 14, 1936 Movement disorders : official journal of the Movement Disorder Society, 28, 14, 1936 Movement disorders : official journal of the Movement Disorder Society, 28, 14, 1936 2013/12 Refereed English Disclose to all
Takahashi R, Yamakado H Takahashi R, Yamakado H Takahashi R, Yamakado H Genetic correction will be a standard method for the patient-derived ips cell research? Genetic correction will be a standard method for the patient-derived ips cell research? Genetic correction will be a standard method for the patient-derived ips cell research? Movement disorders : official journal of the Movement Disorder Society, 28, 14, 1935 Movement disorders : official journal of the Movement Disorder Society, 28, 14, 1935 Movement disorders : official journal of the Movement Disorder Society, 28, 14, 1935 2013/12 Refereed English Disclose to all
Minakawa EN, Yamakado H, Tanaka A, Uemura K, Takeda S, Takahashi R Minakawa EN, Yamakado H, Tanaka A, Uemura K, Takeda S, Takahashi R Minakawa EN, Yamakado H, Tanaka A, Uemura K, Takeda S, Takahashi R Chicken DT40 cell line lacking DJ-1, the gene responsible for familial Parkinson's disease, displays mitochondrial dysfunction. Chicken DT40 cell line lacking DJ-1, the gene responsible for familial Parkinson's disease, displays mitochondrial dysfunction. Chicken DT40 cell line lacking DJ-1, the gene responsible for familial Parkinson's disease, displays mitochondrial dysfunction. Neuroscience research, 77, 4, 228-233 Neuroscience research, 77, 4, 228-233 Neuroscience research, 77, 4, 228-233 2013/12 Refereed English Disclose to all
Ageta-Ishihara N, Yamakado H, Morita T, Hattori S, Takao K, Miyakawa T, Takahashi R, Kinoshita M Ageta-Ishihara N, Yamakado H, Morita T, Hattori S, Takao K, Miyakawa T, Takahashi R, Kinoshita M Ageta-Ishihara N, Yamakado H, Morita T, Hattori S, Takao K, Miyakawa T, Takahashi R, Kinoshita M Chronic overload of SEPT4, a parkin substrate that aggregates in Parkinson's disease, causes behavioral alterations but not neurodegeneration in mice. Chronic overload of SEPT4, a parkin substrate that aggregates in Parkinson's disease, causes behavioral alterations but not neurodegeneration in mice. Chronic overload of SEPT4, a parkin substrate that aggregates in Parkinson's disease, causes behavioral alterations but not neurodegeneration in mice. Molecular brain, 6, 35 Molecular brain, 6, 35 Molecular brain, 6, 35 2013/08 Refereed English Disclose to all
Matsui H, Gavinio R, Asano T, Uemura N, Ito H, Taniguchi Y, Kobayashi Y, Maki T, Shen J, Takeda S, Uemura K, Yamakado H, Takahashi R Matsui H, Gavinio R, Asano T, Uemura N, Ito H, Taniguchi Y, Kobayashi Y, Maki T, Shen J, Takeda S, Uemura K, Yamakado H, Takahashi R Matsui H, Gavinio R, Asano T, Uemura N, Ito H, Taniguchi Y, Kobayashi Y, Maki T, Shen J, Takeda S, Uemura K, Yamakado H, Takahashi R PINK1 and Parkin complementarily protect dopaminergic neurons in vertebrates. PINK1 and Parkin complementarily protect dopaminergic neurons in vertebrates. PINK1 and Parkin complementarily protect dopaminergic neurons in vertebrates. Human molecular genetics, 22, 12, 2423-2434 Human molecular genetics, 22, 12, 2423-2434 Human molecular genetics, 22, 12, 2423-2434 2013/06 Refereed English Disclose to all
Nuber S, Harmuth F, Kohl Z, Adame A, Trejo M, Schönig K, Zimmermann F, Bauer C, Casadei N, Giel C, Calaminus C, Pichler BJ, Jensen PH, Müller CP, Amato D, Kornhuber J, Teismann P, Yamakado H, Takahashi R, Winkler J, Masliah E, Riess O Nuber S, Harmuth F, Kohl Z, Adame A, Trejo M, Schönig K, Zimmermann F, Bauer C, Casadei N, Giel C, Calaminus C, Pichler BJ, Jensen PH, Müller CP, Amato D, Kornhuber J, Teismann P, Yamakado H, Takahashi R, Winkler J, Masliah E, Riess O Nuber S, Harmuth F, Kohl Z, Adame A, Trejo M, Schönig K, Zimmermann F, Bauer C, Casadei N, Giel C, Calaminus C, Pichler BJ, Jensen PH, Müller CP, Amato D, Kornhuber J, Teismann P, Yamakado H, Takahashi R, Winkler J, Masliah E, Riess O A progressive dopaminergic phenotype associated with neurotoxic conversion of α-synuclein in BAC-transgenic rats. A progressive dopaminergic phenotype associated with neurotoxic conversion of α-synuclein in BAC-transgenic rats. A progressive dopaminergic phenotype associated with neurotoxic conversion of α-synuclein in BAC-transgenic rats. Brain : a journal of neurology, 136, Pt 2, 412-432 Brain : a journal of neurology, 136, Pt 2, 412-432 Brain : a journal of neurology, 136, Pt 2, 412-432 2013/02 Refereed English Disclose to all
Yamakado H, Moriwaki Y, Yamasaki N, Miyakawa T, Kurisu J, Uemura K, Inoue H, Takahashi M, Takahashi R Yamakado H, Moriwaki Y, Yamasaki N, Miyakawa T, Kurisu J, Uemura K, Inoue H, Takahashi M, Takahashi R Yamakado H, Moriwaki Y, Yamasaki N, Miyakawa T, Kurisu J, Uemura K, Inoue H, Takahashi M, Takahashi R α-Synuclein BAC transgenic mice as a model for Parkinson's disease manifested decreased anxiety-like behavior and hyperlocomotion. α-Synuclein BAC transgenic mice as a model for Parkinson's disease manifested decreased anxiety-like behavior and hyperlocomotion. α-Synuclein BAC transgenic mice as a model for Parkinson's disease manifested decreased anxiety-like behavior and hyperlocomotion. Neuroscience research, 73, 2, 173-177 Neuroscience research, 73, 2, 173-177 Neuroscience research, 73, 2, 173-177 2012/06 Refereed English Disclose to all
Kondo T, Yamakado H, Kawamata J, Tomimoto H, Hitomi T, Takahashi R, Ikeda A Kondo T, Yamakado H, Kawamata J, Tomimoto H, Hitomi T, Takahashi R, Ikeda A Kondo T, Yamakado H, Kawamata J, Tomimoto H, Hitomi T, Takahashi R, Ikeda A [Unverricht-Lundborg disease manifesting tremulous myoclonus with rare convulsive seizures: a case report]. [Unverricht-Lundborg disease manifesting tremulous myoclonus with rare convulsive seizures: a case report]. [Unverricht-Lundborg disease manifesting tremulous myoclonus with rare convulsive seizures: a case report]. Rinsho shinkeigaku = Clinical neurology, 49, 1, 43-47 Rinsho shinkeigaku = Clinical neurology, 49, 1, 43-47 Rinsho shinkeigaku = Clinical neurology, 49, 1, 43-47 2009/01 Refereed English Disclose to all
Sawada H, Yamakawa K, Yamakado H, Hosokawa R, Ohba M, Miyamoto K, Kawamura T, Shimohama S Sawada H, Yamakawa K, Yamakado H, Hosokawa R, Ohba M, Miyamoto K, Kawamura T, Shimohama S Sawada H, Yamakawa K, Yamakado H, Hosokawa R, Ohba M, Miyamoto K, Kawamura T, Shimohama S Cocaine and phenylephrine eye drop test for Parkinson disease. Cocaine and phenylephrine eye drop test for Parkinson disease. Cocaine and phenylephrine eye drop test for Parkinson disease. JAMA, 293, 8, 932-934 JAMA, 293, 8, 932-934 JAMA, 293, 8, 932-934 2005/02 Refereed English Disclose to all

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Title language:
External funds: competitive funds and Grants-in-Aid for Scientific Research (Kakenhi)
Type Position Title(Japanese) Title(English) Period
若手研究(B) Representative 新しいシヌクレイン遺伝子導入マウスを用いたパーキンソン病発症メカニズムの解明 Investigation of pathomechanism of Parkinson's disease using novel alpha-synuclein-based genetic mice model 2012-2014
若手研究(B) Representative iPS細胞を用いた孤発性パーキンソン病の病態解明と標的分子の同定 Investigation of pathomechanism and identification of therapeutic target of Parkinson's disease using iPS cells 2014-2016
基盤研究(C) Representative 多系統萎縮症の病態解明と治療法の開発 2016-2019
基盤研究(C) Representative 多系統萎縮症の病態解明と治療法の開発 （平成29年度分） 2017/04/01-2018/03/31
基盤研究(C) Representative 多系統萎縮症の病態解明と治療法の開発 （平成30年度分） 2018/04/01-2019/03/31
Faculty management (title, position)
Title Period
動物実験施設運営委員会 2013/04/01-2014/03/31
外来医長・看護師長会議 委員 2014/04/01-

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