茂木 章

Last Update: 2019/06/04 12:13:51

Print

Name(Kanji/Kana/Abecedarium Latinum)
茂木 章/モテギ アキラ/Motegi, Akira
Primary Affiliation(Org1/Job title)
Graduate Schools Medicine/Assistant Professor
Faculty
Org1 Job title
医学部
Academic Organizations You are Affiliated to in Japan
Organization name(Japanese) Organization name(English)
日本分子生物学会 The Molecular Biology Society of Japan
日本生化学会 The Japanese Biochemical Society
日本癌学会 The Japanese Cancer Association
日本放射線影響学会 The Japanese Radiation Research Society
Academic Degree
Field(Japanese) Field(English) University(Japanese) University(English) Method
博士(医学) 東京大学
Graduate School
University(Japanese) University(English) Faculty(Japanese) Faculty(English) Major(Japanese) Major(English) Degree
東京大学 大学院医学研究科博士課程病因・病理学専攻 修了
Undergraduate School / Major(s)
University(Japanese) University(English) Faculty(Japanese) Faculty(English) Major(s)(Japanese) Major(s)(English) Degree
群馬大学 医学部医学科 卒業
Work Experience
Period Organization(Japanese) Organization(English) Job title(Japanese) Job title(English)
2001- 東京大学付属医科学研究所 特別研究員
2001- 米国国立衛生研究所・国立癌研究所 客員研究員
2003- 日本学術振興会 海外特別研究員 (NIH)
2003- 米国国立衛生研究所・国立ヒトゲノム研究所 客員研究員
2006- 米国国立衛生研究所・国立ヒトゲノム研究所 研究員
2007- 京都大学大学院医学研究科 遺伝医学講座 放射線遺伝学分野 助教
researchmap URL
https://researchmap.jp/7000008668
Research Topics
(Japanese)
ゲノム維持機構の分子機序、発がんの分子機序、がんの精密医療の分子基盤
(English)
Molecular mechanisms of genome maintenance, molecular carcinogenesis, and a molecular basis of cancer precision medicine
Overview of the research
(Japanese)
細胞は様々なDNA損傷を修復し、正常なゲノムを維持するための多様な仕組みを備えている。これらの仕組みはがんなどの原因となる遺伝子変異を抑制するとともに、遺伝子変異を積極的に導入する。この諸刃の剣である「ゲノム維持機構」の分子機序を解明することで「発がんの分子機序」を理解し、さらに「がんの精密医療」を実現するための分子基盤の確立を目指している。
(English)
Cells possess mechanisms that sense and respond to various types of DNA damage in the genome. Such mechanisms, collectively called DNA damage response (DDR), are not only the major barriers but also the mediators of pathogenic mutations. My research focuses on uncovering the molecular mechanisms of genome maintenance and thereby facilitating understanding of the molecular carcinogenesis steps and providing a basis for cancer precision medicine.
Fields of research (key words)
Key words(Japanese) Key words(English)
ゲノム維持 genome maintenance
発がんの分子機序 molecular carcinogenesis
がんの精密医療 cancer precision medicine
タンパク質の翻訳後修飾 protein post-translational modifications
Published Papers
Author Author(Japanese) Author(English) Title Title(Japanese) Title(English) Bibliography Bibliography(Japanese) Bibliography(English) Publication date Refereed paper Language Publishing type Disclose
Motegi A, Masutani M, Yoshioka KI, Bessho T Motegi A, Masutani M, Yoshioka KI, Bessho T Motegi A, Masutani M, Yoshioka KI, Bessho T Aberrations in DNA repair pathways in cancer and therapeutic significances. Aberrations in DNA repair pathways in cancer and therapeutic significances. Aberrations in DNA repair pathways in cancer and therapeutic significances. Seminars in cancer biology Seminars in cancer biology Seminars in cancer biology 2019/03 Refereed Disclose to all
Mochizuki AL, Katanaya A, Hayashi E, Hosokawa M, Moribe E, Motegi A, Ishiai M, Takata M, Kondoh G, Watanabe H, Nakatsuji N, Chuma S Mochizuki AL, Katanaya A, Hayashi E, Hosokawa M, Moribe E, Motegi A, Ishiai M, Takata M, Kondoh G, Watanabe H, Nakatsuji N, Chuma S Mochizuki AL, Katanaya A, Hayashi E, Hosokawa M, Moribe E, Motegi A, Ishiai M, Takata M, Kondoh G, Watanabe H, Nakatsuji N, Chuma S PARI Regulates Stalled Replication Fork Processing To Maintain Genome Stability upon Replication Stress in Mice. PARI Regulates Stalled Replication Fork Processing To Maintain Genome Stability upon Replication Stress in Mice. PARI Regulates Stalled Replication Fork Processing To Maintain Genome Stability upon Replication Stress in Mice. Molecular and cellular biology, 37, 23 Molecular and cellular biology, 37, 23 Molecular and cellular biology, 37, 23 2017/12 Refereed Disclose to all
Niida H, Matsunuma R, Horiguchi R, Uchida C, Nakazawa Y, Motegi A, Nishimoto K, Sakai S, Ohhata T, Kitagawa K, Moriwaki S, Nishitani H, Ui A, Ogi T, Kitagawa M Niida H, Matsunuma R, Horiguchi R, Uchida C, Nakazawa Y, Motegi A, Nishimoto K, Sakai S, Ohhata T, Kitagawa K, Moriwaki S, Nishitani H, Ui A, Ogi T, Kitagawa M Niida H, Matsunuma R, Horiguchi R, Uchida C, Nakazawa Y, Motegi A, Nishimoto K, Sakai S, Ohhata T, Kitagawa K, Moriwaki S, Nishitani H, Ui A, Ogi T, Kitagawa M Phosphorylated HBO1 at UV irradiated sites is essential for nucleotide excision repair. Phosphorylated HBO1 at UV irradiated sites is essential for nucleotide excision repair. Phosphorylated HBO1 at UV irradiated sites is essential for nucleotide excision repair. Nature communications, 8, 16102 Nature communications, 8, 16102 Nature communications, 8, 16102 2017/07 Refereed Disclose to all
Wang J, Ding Q, Fujimori H, Motegi A, Miki Y, Masutani M Wang J, Ding Q, Fujimori H, Motegi A, Miki Y, Masutani M Wang J, Ding Q, Fujimori H, Motegi A, Miki Y, Masutani M Loss of CtIP disturbs homologous recombination repair and sensitizes breast cancer cells to PARP inhibitors. Loss of CtIP disturbs homologous recombination repair and sensitizes breast cancer cells to PARP inhibitors. Loss of CtIP disturbs homologous recombination repair and sensitizes breast cancer cells to PARP inhibitors. Oncotarget, 7, 7, 7701-7714 Oncotarget, 7, 7, 7701-7714 Oncotarget, 7, 7, 7701-7714 2016/02 Refereed Disclose to all
Kobayashi S, Kasaishi Y, Nakada S, Takagi T, Era S, Motegi A, Chiu RK, Takeda S, Hirota K Kobayashi S, Kasaishi Y, Nakada S, Takagi T, Era S, Motegi A, Chiu RK, Takeda S, Hirota K Kobayashi S, Kasaishi Y, Nakada S, Takagi T, Era S, Motegi A, Chiu RK, Takeda S, Hirota K Rad18 and Rnf8 facilitate homologous recombination by two distinct mechanisms, promoting Rad51 focus formation and suppressing the toxic effect of nonhomologous end joining. Rad18 and Rnf8 facilitate homologous recombination by two distinct mechanisms, promoting Rad51 focus formation and suppressing the toxic effect of nonhomologous end joining. Rad18 and Rnf8 facilitate homologous recombination by two distinct mechanisms, promoting Rad51 focus formation and suppressing the toxic effect of nonhomologous end joining. Oncogene, 34, 33, 4403-4411 Oncogene, 34, 33, 4403-4411 Oncogene, 34, 33, 4403-4411 2015/08 Refereed Disclose to all
Schmid M, Smith J, Burt DW, Aken BL, Antin PB, Archibald AL, Ashwell C, Blackshear PJ, Boschiero C, Brown CT, Burgess SC, Cheng HH, Chow W, Coble DJ, Cooksey A, Crooijmans RP, Damas J, Davis RV, de Koning DJ, Delany ME, Derrien T, Desta TT, Dunn IC, Dunn M, Ellegren H, Eöry L, Erb I, Farré M, Fasold M, Fleming D, Flicek P, Fowler KE, Frésard L, Froman DP, Garceau V, Gardner PP, Gheyas AA, Griffin DK, Groenen MA, Haaf T, Hanotte O, Hart A, Häsler J, Hedges SB, Hertel J, Howe K, Hubbard A, Hume DA, Kaiser P, Kedra D, Kemp SJ, Klopp C, Kniel KE, Kuo R, Lagarrigue S, Lamont SJ, Larkin DM, Lawal RA, Markland SM, McCarthy F, McCormack HA, McPherson MC, Motegi A, Muljo SA, Münsterberg A, Nag R, Nanda I, Neuberger M, Nitsche A, Notredame C, Noyes H, O'Connor R, O'Hare EA, Oler AJ, Ommeh SC, Pais H, Persia M, Pitel F, Preeyanon L, Prieto Barja P, Pritchett EM, Rhoads DD, Robinson CM, Romanov MN, Rothschild M, Roux PF, Schmidt CJ, Schneider AS, Schwartz MG, Searle SM, Skinner MA, Smith CA, Stadler PF, Steeves TE, Steinlein C, Sun L, Takata M, Ulitsky I, Wang Q, Wang Y, Warren WC, Wood JM, Wragg D, Zhou H Schmid M, Smith J, Burt DW, Aken BL, Antin PB, Archibald AL, Ashwell C, Blackshear PJ, Boschiero C, Brown CT, Burgess SC, Cheng HH, Chow W, Coble DJ, Cooksey A, Crooijmans RP, Damas J, Davis RV, de Koning DJ, Delany ME, Derrien T, Desta TT, Dunn IC, Dunn M, Ellegren H, Eöry L, Erb I, Farré M, Fasold M, Fleming D, Flicek P, Fowler KE, Frésard L, Froman DP, Garceau V, Gardner PP, Gheyas AA, Griffin DK, Groenen MA, Haaf T, Hanotte O, Hart A, Häsler J, Hedges SB, Hertel J, Howe K, Hubbard A, Hume DA, Kaiser P, Kedra D, Kemp SJ, Klopp C, Kniel KE, Kuo R, Lagarrigue S, Lamont SJ, Larkin DM, Lawal RA, Markland SM, McCarthy F, McCormack HA, McPherson MC, Motegi A, Muljo SA, Münsterberg A, Nag R, Nanda I, Neuberger M, Nitsche A, Notredame C, Noyes H, O'Connor R, O'Hare EA, Oler AJ, Ommeh SC, Pais H, Persia M, Pitel F, Preeyanon L, Prieto Barja P, Pritchett EM, Rhoads DD, Robinson CM, Romanov MN, Rothschild M, Roux PF, Schmidt CJ, Schneider AS, Schwartz MG, Searle SM, Skinner MA, Smith CA, Stadler PF, Steeves TE, Steinlein C, Sun L, Takata M, Ulitsky I, Wang Q, Wang Y, Warren WC, Wood JM, Wragg D, Zhou H Schmid M, Smith J, Burt DW, Aken BL, Antin PB, Archibald AL, Ashwell C, Blackshear PJ, Boschiero C, Brown CT, Burgess SC, Cheng HH, Chow W, Coble DJ, Cooksey A, Crooijmans RP, Damas J, Davis RV, de Koning DJ, Delany ME, Derrien T, Desta TT, Dunn IC, Dunn M, Ellegren H, Eöry L, Erb I, Farré M, Fasold M, Fleming D, Flicek P, Fowler KE, Frésard L, Froman DP, Garceau V, Gardner PP, Gheyas AA, Griffin DK, Groenen MA, Haaf T, Hanotte O, Hart A, Häsler J, Hedges SB, Hertel J, Howe K, Hubbard A, Hume DA, Kaiser P, Kedra D, Kemp SJ, Klopp C, Kniel KE, Kuo R, Lagarrigue S, Lamont SJ, Larkin DM, Lawal RA, Markland SM, McCarthy F, McCormack HA, McPherson MC, Motegi A, Muljo SA, Münsterberg A, Nag R, Nanda I, Neuberger M, Nitsche A, Notredame C, Noyes H, O'Connor R, O'Hare EA, Oler AJ, Ommeh SC, Pais H, Persia M, Pitel F, Preeyanon L, Prieto Barja P, Pritchett EM, Rhoads DD, Robinson CM, Romanov MN, Rothschild M, Roux PF, Schmidt CJ, Schneider AS, Schwartz MG, Searle SM, Skinner MA, Smith CA, Stadler PF, Steeves TE, Steinlein C, Sun L, Takata M, Ulitsky I, Wang Q, Wang Y, Warren WC, Wood JM, Wragg D, Zhou H Third Report on Chicken Genes and Chromosomes 2015. Third Report on Chicken Genes and Chromosomes 2015. Third Report on Chicken Genes and Chromosomes 2015. Cytogenetic and genome research, 145, 2, 78-179 Cytogenetic and genome research, 145, 2, 78-179 Cytogenetic and genome research, 145, 2, 78-179 2015 Refereed Disclose to all
Akira Motegi and Minoru Takata Akira Motegi and Minoru Takata Akira Motegi and Minoru Takata Multiple genetic manipulations of DT40 cell line Multiple genetic manipulations of DT40 cell line Multiple genetic manipulations of DT40 cell line Methods in Mol. Biol. 1114:25-35 (2014), 1114, 25-35 Methods in Mol. Biol. 1114:25-35 (2014), 1114, 25-35 Methods in Mol. Biol. 1114:25-35 (2014), 1114, 25-35 2014 Refereed English Disclose to all
S. Era; T. Abe; H. Arakawa; S. Kobayashi; B. Szakal; Y. Yoshikawa; A. Motegi; S. Takeda; D. Branzei S. Era; T. Abe; H. Arakawa; S. Kobayashi; B. Szakal; Y. Yoshikawa; A. Motegi; S. Takeda; D. Branzei S. Era; T. Abe; H. Arakawa; S. Kobayashi; B. Szakal; Y. Yoshikawa; A. Motegi; S. Takeda; D. Branzei The SUMO protease SENP1 is required for cohesion maintenance and mitotic arrest following spindle poison treatment The SUMO protease SENP1 is required for cohesion maintenance and mitotic arrest following spindle poison treatment The SUMO protease SENP1 is required for cohesion maintenance and mitotic arrest following spindle poison treatment Biochemical and Biophysical Research Communications, 426, 3, 310-316 Biochemical and Biophysical Research Communications, 426, 3, 310-316 Biochemical and Biophysical Research Communications, 426, 3, 310-316 2012/09/28 Refereed English Disclose to all
S.M. Germann; V.H. Oestergaard; C. Haas; P. Salis; A. Motegi; M. Lisby S.M. Germann; V.H. Oestergaard; C. Haas; P. Salis; A. Motegi; M. Lisby S.M. Germann; V.H. Oestergaard; C. Haas; P. Salis; A. Motegi; M. Lisby Dpb11/TopBP1 plays distinct roles in DNA replication, checkpoint response and homologous recombination Dpb11/TopBP1 plays distinct roles in DNA replication, checkpoint response and homologous recombination Dpb11/TopBP1 plays distinct roles in DNA replication, checkpoint response and homologous recombination DNA Repair, 10, 2, 210-224 DNA Repair, 10, 2, 210-224 DNA Repair, 10, 2, 210-224 2011/02/07 Refereed English Disclose to all
K. Hirota; E. Sonoda; T. Kawamoto; A. Motegi; C. Masutani; F. Hanaoka; D. Szüts; S. Iwai; J.E. Sale; A. Lehmann; S. Takeda K. Hirota; E. Sonoda; T. Kawamoto; A. Motegi; C. Masutani; F. Hanaoka; D. Szüts; S. Iwai; J.E. Sale; A. Lehmann; S. Takeda K. Hirota; E. Sonoda; T. Kawamoto; A. Motegi; C. Masutani; F. Hanaoka; D. Szüts; S. Iwai; J.E. Sale; A. Lehmann; S. Takeda Simultaneous disruption of two DNA polymerases, Polη and Polζ, in avian DT40 cells unmasks the role of Polη in cellular response to various DNA lesions Simultaneous disruption of two DNA polymerases, Polη and Polζ, in avian DT40 cells unmasks the role of Polη in cellular response to various DNA lesions Simultaneous disruption of two DNA polymerases, Polη and Polζ, in avian DT40 cells unmasks the role of Polη in cellular response to various DNA lesions PLoS Genetics, 6, 10, 1-13 PLoS Genetics, 6, 10, 1-13 PLoS Genetics, 6, 10, 1-13 2010/10 Refereed English Disclose to all
A. Motegi; Y. Murakawa; S. Takeda A. Motegi; Y. Murakawa; S. Takeda A. Motegi; Y. Murakawa; S. Takeda The vital link between the ubiquitin-proteasome pathway and DNA repair: Impact on cancer therapy The vital link between the ubiquitin-proteasome pathway and DNA repair: Impact on cancer therapy The vital link between the ubiquitin-proteasome pathway and DNA repair: Impact on cancer therapy Cancer Letters, 283, 1, 1-9 Cancer Letters, 283, 1, 1-9 Cancer Letters, 283, 1, 1-9 2009/09/28 Refereed English Disclose to all
A. Motegi A. Motegi A. Motegi Maintenance of genome stability though ubcl3-dependent ubiquitination Maintenance of genome stability though ubcl3-dependent ubiquitination Maintenance of genome stability though ubcl3-dependent ubiquitination Seikagaku, 81, 7, 601-605 Seikagaku, 81, 7, 601-605 Seikagaku, 81, 7, 601-605 2009/07 Refereed English Disclose to all
A. Motegi; S. Takeda A. Motegi; S. Takeda A. Motegi; S. Takeda [Function of homologous recombination-mediated DNA repair]. [Function of homologous recombination-mediated DNA repair]. [Function of homologous recombination-mediated DNA repair]. Tanpakushitsu kakusan koso. Protein, nucleic acid, enzyme, 54, 4 Suppl, 450-458 Tanpakushitsu kakusan koso. Protein, nucleic acid, enzyme, 54, 4 Suppl, 450-458 Tanpakushitsu kakusan koso. Protein, nucleic acid, enzyme, 54, 4 Suppl, 450-458 2009/03 Refereed English Disclose to all
A. Motegi; H.-J. Liaw; K.-Y. Lee; H.P. Roest; A. Maas; X. Wu; H. Moinova; S.D. Markowitz; H. Ding; J.H.J. Hoeijmakers; K. Myung A. Motegi; H.-J. Liaw; K.-Y. Lee; H.P. Roest; A. Maas; X. Wu; H. Moinova; S.D. Markowitz; H. Ding; J.H.J. Hoeijmakers; K. Myung A. Motegi; H.-J. Liaw; K.-Y. Lee; H.P. Roest; A. Maas; X. Wu; H. Moinova; S.D. Markowitz; H. Ding; J.H.J. Hoeijmakers; K. Myung Polyubiquitination of proliferating cell nuclear antigen by HLTF and SHPRH prevents genomic instability from stalled replication forks Polyubiquitination of proliferating cell nuclear antigen by HLTF and SHPRH prevents genomic instability from stalled replication forks Polyubiquitination of proliferating cell nuclear antigen by HLTF and SHPRH prevents genomic instability from stalled replication forks Proceedings of the National Academy of Sciences of the United States of America, 105, 34, 12411-12416 Proceedings of the National Academy of Sciences of the United States of America, 105, 34, 12411-12416 Proceedings of the National Academy of Sciences of the United States of America, 105, 34, 12411-12416 2008/08/26 Refereed English Disclose to all
Banerjee S, Smith S, Oum JH, Liaw HJ, Hwang JY, Sikdar N, Motegi A, Lee SE, Myung K Banerjee S, Smith S, Oum JH, Liaw HJ, Hwang JY, Sikdar N, Motegi A, Lee SE, Myung K Banerjee S, Smith S, Oum JH, Liaw HJ, Hwang JY, Sikdar N, Motegi A, Lee SE, Myung K Mph1p promotes gross chromosomal rearrangement through partial inhibition of homologous recombination. Mph1p promotes gross chromosomal rearrangement through partial inhibition of homologous recombination. Mph1p promotes gross chromosomal rearrangement through partial inhibition of homologous recombination. The Journal of cell biology, 181, 7, 1083-1093 The Journal of cell biology, 181, 7, 1083-1093 The Journal of cell biology, 181, 7, 1083-1093 2008/06 Refereed Disclose to all
A. Motegi; K. Myung A. Motegi; K. Myung A. Motegi; K. Myung Measuring the rate of gross chromosomal rearrangements in Saccharomyces cerevisiae: A practical approach to study genomic rearrangements observed in cancer Measuring the rate of gross chromosomal rearrangements in Saccharomyces cerevisiae: A practical approach to study genomic rearrangements observed in cancer Measuring the rate of gross chromosomal rearrangements in Saccharomyces cerevisiae: A practical approach to study genomic rearrangements observed in cancer Methods, 41, 2, 168-176 Methods, 41, 2, 168-176 Methods, 41, 2, 168-176 2007/02 Refereed English Disclose to all
A. Motegi; R. Sood; H. Moinova; S.D. Markowitz; P.P. Liu; K. Myung A. Motegi; R. Sood; H. Moinova; S.D. Markowitz; P.P. Liu; K. Myung A. Motegi; R. Sood; H. Moinova; S.D. Markowitz; P.P. Liu; K. Myung Human SHPRH suppresses genomic instability through proliferating cell nuclear antigen polyubiquitination Human SHPRH suppresses genomic instability through proliferating cell nuclear antigen polyubiquitination Human SHPRH suppresses genomic instability through proliferating cell nuclear antigen polyubiquitination Journal of Cell Biology, 175, 5, 703-708 Journal of Cell Biology, 175, 5, 703-708 Journal of Cell Biology, 175, 5, 703-708 2006/12/04 Refereed English Disclose to all
Chen CC, Motegi A, Hasegawa Y, Myung K, Kolodner R, D'Andrea A Chen CC, Motegi A, Hasegawa Y, Myung K, Kolodner R, D'Andrea A Chen CC, Motegi A, Hasegawa Y, Myung K, Kolodner R, D'Andrea A Genetic analysis of ionizing radiation-induced mutagenesis in Saccharomyces cerevisiae reveals TransLesion Synthesis (TLS) independent of PCNA K164 SUMOylation and ubiquitination. Genetic analysis of ionizing radiation-induced mutagenesis in Saccharomyces cerevisiae reveals TransLesion Synthesis (TLS) independent of PCNA K164 SUMOylation and ubiquitination. Genetic analysis of ionizing radiation-induced mutagenesis in Saccharomyces cerevisiae reveals TransLesion Synthesis (TLS) independent of PCNA K164 SUMOylation and ubiquitination. DNA repair, 5, 12, 1475-1488 DNA repair, 5, 12, 1475-1488 DNA repair, 5, 12, 1475-1488 2006/12 Refereed Disclose to all
A. Motegi; K. Kuntz; A. Majeed; S. Smith; K. Myung A. Motegi; K. Kuntz; A. Majeed; S. Smith; K. Myung A. Motegi; K. Kuntz; A. Majeed; S. Smith; K. Myung Regulation of gross chromosomal rearrangements by ubiquitin and SUMO ligases in Saccharomyces cerevisiae Regulation of gross chromosomal rearrangements by ubiquitin and SUMO ligases in Saccharomyces cerevisiae Regulation of gross chromosomal rearrangements by ubiquitin and SUMO ligases in Saccharomyces cerevisiae Molecular and Cellular Biology, 26, 4, 1424-1433 Molecular and Cellular Biology, 26, 4, 1424-1433 Molecular and Cellular Biology, 26, 4, 1424-1433 2006/02 Refereed English Disclose to all
Clark Chen, Akira Motegi, Yuko Hasegawa, Richard Kolodner, Kyungjae Myung, and Alan D’Andrea Clark Chen, Akira Motegi, Yuko Hasegawa, Richard Kolodner, Kyungjae Myung, and Alan D’Andrea Clark Chen, Akira Motegi, Yuko Hasegawa, Richard Kolodner, Kyungjae Myung, and Alan D’Andrea Genetic analysis of ionization-induced mutagenesis in Saccharomyces cerevisiae revealed a complex network of overlapping mutagenic pathways Genetic analysis of ionization-induced mutagenesis in Saccharomyces cerevisiae revealed a complex network of overlapping mutagenic pathways Genetic analysis of ionization-induced mutagenesis in Saccharomyces cerevisiae revealed a complex network of overlapping mutagenic pathways DNA Repair 5:1475-1488 (2006) DNA Repair 5:1475-1488 (2006) DNA Repair 5:1475-1488 (2006) 2006 Refereed English Disclose to all
A. Motegi; J. Fujimoto; M. Kotani; H. Sakuraba; T. Yamamoto A. Motegi; J. Fujimoto; M. Kotani; H. Sakuraba; T. Yamamoto A. Motegi; J. Fujimoto; M. Kotani; H. Sakuraba; T. Yamamoto ALK receptor tyrosine kinase promotes cell growth and neurite outgrowth ALK receptor tyrosine kinase promotes cell growth and neurite outgrowth ALK receptor tyrosine kinase promotes cell growth and neurite outgrowth Journal of Cell Science, 117, 15, 3319-3329 Journal of Cell Science, 117, 15, 3319-3329 Journal of Cell Science, 117, 15, 3319-3329 2004/07/01 Refereed English Disclose to all
P. Olsson; A. Motegi; T.K. Bera; B. Lee; I. Pastan P. Olsson; A. Motegi; T.K. Bera; B. Lee; I. Pastan P. Olsson; A. Motegi; T.K. Bera; B. Lee; I. Pastan PRAC2: A new gene expressed in human prostate and prostate cancer PRAC2: A new gene expressed in human prostate and prostate cancer PRAC2: A new gene expressed in human prostate and prostate cancer Prostate, 56, 2, 123-130 Prostate, 56, 2, 123-130 Prostate, 56, 2, 123-130 2003/07 Refereed English Disclose to all

  • <<
  • >>
Title language:
Misc
Author Author(Japanese) Author(English) Title Title(Japanese) Title(English) Bibliography Bibliography(Japanese) Bibliography(English) Publication date Refereed paper Language Publishing type Disclose
足立淳,鳴海良平,佐野聖三,久家貴寿,白水崇,松本雅記,中山敬一,茂木章,井倉毅,高田穣,朝長毅 足立淳,鳴海良平,佐野聖三,久家貴寿,白水崇,松本雅記,中山敬一,茂木章,井倉毅,高田穣,朝長毅 足立淳,鳴海良平,佐野聖三,久家貴寿,白水崇,松本雅記,中山敬一,茂木章,井倉毅,高田穣,朝長毅 「DNA 損傷応答ネットワークにおけるリン酸化・ユビキチン化修飾ダイナミクスのプロテオーム解析」 「DNA 損傷応答ネットワークにおけるリン酸化・ユビキチン化修飾ダイナミクスのプロテオーム解析」 「DNA 損傷応答ネットワークにおけるリン酸化・ユビキチン化修飾ダイナミクスのプロテオーム解析」 第33 回日本分子生物学会年会第83 回「」本生化学会大会合同大会 2010 年12 月 第33 回日本分子生物学会年会第83 回「」本生化学会大会合同大会 2010 年12 月 第33 回日本分子生物学会年会第83 回「」本生化学会大会合同大会 2010 年12 月 2010 Refereed Japanese Disclose to all
Title language:
Awards
Title(Japanese) Title(English) Organization name(Japanese) Organization name(English) Date
2005 Keystone Symposia Scholarship Award 2005
External funds: competitive funds and Grants-in-Aid for Scientific Research (Kakenhi)
Type Position Title(Japanese) Title(English) Period
基盤研究(A) Assignment ニワトリ細胞株DT40の遺伝子破壊による、DNA損傷への応答機構の網羅的解析 Analysis of DNA damage response using gene-disrupted DT40 clones. 2008-2010
基盤研究(C) Representative ユビキチン化によるDNA修復制御機構の解明 2010-2012
若手スタートアップ研究 Representative ユビキチン化によるDNA複製停止解除の制御機構の解明 Ubiquitin-dependent regulation of DNA replication arrest 2013-2016
基盤研究(C) Representative DNA複製阻害を解除する損傷トレランス機構の解明 2013-2015
基盤研究(C) Representative DNA複製阻害を解除する損傷トレランス機構の解明 (平成26年度分) 2014/04/01-2015/03/31
基盤研究(C) Representative DNA複製阻害を解除する損傷トレランス機構の解明 (平成27年度分) 2015/04/01-2016/03/31
基盤研究(C) Representative DNA複製阻害を解除する損傷トレランス機構の解明 (平成28年度分) 2016/04/01-2017/03/31
基盤研究(C) Representative 鋳型乗り換え経路によるゲノム維持機構の解明 (平成29年度分) 2017/04/01-2018/03/31
基盤研究(C) Representative 鋳型乗り換え経路によるゲノム維持機構の解明 (平成30年度分) 2018/04/01-2019/03/31
School management (title, position)
Title Period
京都大学無機廃液処理装置(KMS)指導員 -
エネルギー管理要員 -
放射線障害予防小委員会 2017/04/01-2019/03/31
Faculty management (title, position)
Title Period
医学図書館連絡委員 -2019/03/31
放射線障害防止委員会 -