原田 浩

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Name(Kanji/Kana/Abecedarium Latinum)
原田 浩/ハラダ ヒロシ/Harada, Hiroshi
Primary Affiliation(Org1/Job title)
Graduate Schools Biostudies/Professor
Affiliated programs (koza)
Org1 Job title
Graduate Schools Medicine Professor
Concurrent Affiliation
Org1 Job title
Graduate Schools Medicine
Graduate Schools Biostudies
Graduate Schools Pharmaceutical Sciences
Contact Address
Type Address(Japanese) Address(English)
Office 京都府京都市左京区吉田近衛町 Yoshida-Konoe-cho, Sakyo-ku, Kyoto 606-8501, Japan.
E-mail Address
E-mail address
harada.hiroshi.5e @ kyoto-u.ac.jp
Academic Organizations You are Affiliated to in Japan
Organization name(Japanese) Organization name(English)
日本癌学会 Japanese Cancer Association
日本がん分子標的治療学会 The Japanese Association for Molecular Target Therapy of Cancer
日本放射線影響学会 Japan Radiation Research Society
日本放射線腫瘍学会 Japanese Society for Therapeutic Radiology and Oncology
日本分子生物学会 The Molecular Biology Society of Jpan
日本宇宙生物科学会 Japanese Society for Biological Science in Space
がんとハイポキシア研究会 The Japanese Association for Cancer and Hypoxia Research
Academic Organizations Overaseas You are Affiliated to
Organization name Country
Radiation Research Society United States of America
International Association for the Sensitization of Cancer Treatment Japan
Academic Degree
Field(Japanese) Field(English) University(Japanese) University(English) Method
修士(理学) M. S. in Graduate School of Science 名古屋大学 Nagoya University
博士(理学) Ph. D. in Graduate School of Science 名古屋大学 Nagoya University
Graduate School
University(Japanese) University(English) Faculty(Japanese) Faculty(English) Major(Japanese) Major(English) Degree
名古屋大学 Nagoya University 大学院理学研究科博士課程前期課程生命理学専攻 Graduate School of Science Division of Biological Science 修了
Undergraduate School / Major(s)
University(Japanese) University(English) Faculty(Japanese) Faculty(English) Major(s)(Japanese) Major(s)(English) Degree
名古屋大学 Nagoya University 理学部分子生物学科 School of Science Division of Biological Science 卒業
High School
Highschool Kana
愛知県立旭丘高等学校 あいちけんりつ あさひがおか こうとうがっこう
Work Experience
Period Organization(Japanese) Organization(English) Job title(Japanese) Job title(English)
1998/04/01-2003/02/28 ポーラ化成工業(株)医薬品研究所 POLA Chemical Inductries, Inc. 研究員 Research Scientist
2003/03/01-2005/03/31 京都大学大学院医学研究科 Department of Radiation Oncology and Image-applied Therapy, Kyoto University Graduate School of Medicine. 特任助教 Assistant Professor
2005/04/01-2005/09/30 (財)京都高度技術研究所 Kyoto City Collaboration of Regional Entities for the Advancement of Technological Excellence 研究員 Research Associate
2005/10/01-2008/03/31 京都大学大学院医学研究科 Department of Radiation Oncology and Image-applied Therapy, Kyoto University Graduate School of Medicine. 特定助教(科学技術振興) Assistant Professor
2008/04/01-2009/11/30 京都大学大学院医学研究科 Department of Radiation Oncology and Image-applied Therapy, Kyoto University Graduate School of Medicine. 特定講師(科学技術振興) Lecturer
2009/12/01-2013/03/31 京都大学生命科学系キャリアパス形成ユニット Career-Path Promotion Unit for Young Life Scientists, Kyoto University. 講師 Lecturer
2013/04/01-2015/03/31 京都大学医学部附属病院放射線治療科 Department of Radiation Oncology, Kyoto University Hospital. 特定准教授(産官学連携) Associate Professor
2015/04/01-2016/03/31 京都大学白眉センター Hakubi Center, Kyoto University 特定准教授 Associate Professor
2015/04/01-2016/03/31 京都大学大学院医学研究科放射線腫瘍学・画像応用治療学 Department of Radiaiton Oncology and Image-applied Therapy, Kyoto University Graduate School of Medicine 特定准教授(兼任) Associate Professor
2014/10/01-2018/33/1 科学技術振興機構 さきがけ JST PRESTO さきがけ研究者(兼任) PRESTO Researcher
2016/04/01-2018/03/31 京都大学放射線生物研究センターがん細胞生物学 Laboratory of Cancer Cell Biology, Radiation Biology Center, Kyoto University 教授 Professor
2018/04/01- 京都大学大学院生命科学研究科がん細胞生物学分野 Laboratory of Cancer Cell Biology, Graduate School of Biostudies, Kyoto University 教授 Professor
2019/04/01- 京都大学大学院生命科学研究科附属放射線生物研究センター Radiation Biology Center, Graduate School of Biostudies, Kyoto University センター長 Director

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Language of Instruction
Language(japanese) Language(english) Code
日本語 Japanese jpn
英語 English eng
Personal Website(s) (URL(s))
URL
http://www.rbc.kyoto-u.ac.jp/cancer_biology
ORCID ID
https://orcid.org/0000-0001-7507-3173
researchmap URL
https://researchmap.jp/7000008435
Research Topics
(Japanese)
1) 腫瘍特異的微小環境におけるがん細胞の悪性形質獲得機構と治療抵抗性獲得機構の解明、 2) 細胞の細胞外環境適応機構の解明
(English)
1. Molecular mechanisms behind malignant progression and chemo- and radio-resistance of cancer cells under intratumoral microenvironments. 2. Molecular mechanisms behind cellular adaptive response to extracellular microenvironments.
Overview of the research
(Japanese)
悪性固形腫瘍(固形がん)内部の微小環境は極めて多様で、腫瘍血管からの距離に応じて酸素、栄養源、pHの分布が大きく異なることが知られている。腫瘍内微小環境に対する細胞の適応応答機構が、がんの悪性形質や放射線・抗がん剤抵抗性を誘導することが報告されているが、そのメカニズムは解明されていない。この様な状況下、我々の研究室では「低酸素誘導性転写因子hypoxia-inducible factor 1(HIF-1)に着目し、がん細胞の環境応答と悪性化を担う遺伝子ネットワークを同定すること、そして得られた知見を新たな治療法の確立に繋げること」を目指して研究を進めている。
(English)
Malignant solid tumors contain hypoxic regions due to uncontrolled proliferation of cancer cells and insufficient formation of a vascular network. Accumulating evidence has suggested that hypoxia-inducible factor 1 (HIF-1) functions in not only cellular adaptive response to hypoxia but also malignant progression and chemo- and radio-resistance of cancer cells. However, gene networks responsible for the activation of HIF-1 have not yet been fully elucidated, which makes it difficult to develop novel therapeutic strategies for cancers. We aim at identifying novel HIF-1-related and hypoxia-dependent gene networks and utilizing them as rational targets for cancer therapies.
Fields of research (key words)
Key words(Japanese) Key words(English)
放射線腫瘍生物学、腫瘍内微小環境、放射線抵抗性、がん、低酸素、HIF-1、光イメージング Radiation and Tumor Biology, Tumor microenvironment, Radioresistance, Cancer, Hypoxia, HIF-1, Optical Imaging
Published Papers
Author Author(Japanese) Author(English) Title Title(Japanese) Title(English) Bibliography Bibliography(Japanese) Bibliography(English) Publication date Refereed paper Language Publishing type Disclose
小林稔 原田浩 小林稔 原田浩 酸素環境感知の基本メカニズムとがん 酸素環境感知の基本メカニズムとがん 実験医学(酸素環境と臓器機能), 38, 1429-1435 実験医学(酸素環境と臓器機能), 38, 1429-1435 , 38, 1429-1435 2020/06 Japanese Research paper(scientific journal) Disclose to all
Yamayoshi A, Oyama S, Kishimoto Y, Konishi R, Yamamoto T, Kobori A, Harada H, Ashihara E, Sugiyama H, Murakami A Yamayoshi A, Oyama S, Kishimoto Y, Konishi R, Yamamoto T, Kobori A, Harada H, Ashihara E, Sugiyama H, Murakami A Development of antibody-oligonucleotide complexes for targeting exosomalmicroRNA. Development of antibody-oligonucleotide complexes for targeting exosomalmicroRNA. Development of antibody-oligonucleotide complexes for targeting exosomalmicroRNA. Pharmaceutics, in press Pharmaceutics, in press Pharmaceutics, in press 2020/06 Refereed English Research paper(scientific journal) Disclose to all
Furukawa S, Nagamatsu A, Nenoi M, Fujimori A, Kakinuma S, Katsube T, WangB, Tsuruoka C, Shirai T, Nakamura AJ, Sakaue-Sawano A, Miyawaki A, Harada H, Kobayashi M, Kobayashi J, Kunieda T, Funayama T, Suzuki M, Miyamoto T, Hidema J, Yoshida Y, Takahashi A Furukawa S, Nagamatsu A, Nenoi M, Fujimori A, Kakinuma S, Katsube T, WangB, Tsuruoka C, Shirai T, Nakamura AJ, Sakaue-Sawano A, Miyawaki A, Harada H, Kobayashi M, Kobayashi J, Kunieda T, Funayama T, Suzuki M, Miyamoto T, Hidema J, Yoshida Y, Takahashi A Space Radiation Biology for "Living in Space" Space Radiation Biology for "Living in Space" Space Radiation Biology for "Living in Space" BioMed Res Int'l, 4703286 , 4703286 BioMed Res Int'l, 4703286 2020/04 Refereed English Research paper(scientific journal) Disclose to all
原田浩 原田浩 低酸素バイオロジーの創造と進展 低酸素バイオロジーの創造と進展 放射線生物研究, 55, 61-67 放射線生物研究, 55, 61-67 , 55, 61-67 2020/03 Refereed Japanese Research paper(scientific journal) Disclose to all
Mehryar Habibi Roudkenar, Motoi Fukumoto, Amaneh Mohammadi Roushandeh, Youshikazu Kuwahra, Yusuke Uroshihara, Hiroshi Harada, Manabu Fukumoto Mehryar Habibi Roudkenar, Motoi Fukumoto, Amaneh Mohammadi Roushandeh, Youshikazu Kuwahra, Yusuke Uroshihara, Hiroshi Harada, Manabu Fukumoto Disturbance in the Regulation of miR 17-92 Cluster on HIF-1-α Expression Contributes to Clinically Relevant Radioresistant Cells: An in Vitro Study Disturbance in the Regulation of miR 17-92 Cluster on HIF-1-α Expression Contributes to Clinically Relevant Radioresistant Cells: An in Vitro Study Disturbance in the Regulation of miR 17-92 Cluster on HIF-1-α Expression Contributes to Clinically Relevant Radioresistant Cells: An in Vitro Study Cytotechnology, 72, 1, 141-153 , 72, 1, 141-153 Cytotechnology, 72, 1, 141-153 2020/02 Refereed English Research paper(scientific journal) Disclose to all
Li X, Hattori A, Takahashi S, Goto Y, Harada H, Kakeya H Li X, Hattori A, Takahashi S, Goto Y, Harada H, Kakeya H Li X, Hattori A, Takahashi S, Goto Y, Harada H, Kakeya H Ubiquitin carboxyl-terminal hydrolase L1 promotes hypoxia-inducible factor 1-dependent tumor cell malignancy in spheroid models. Ubiquitin carboxyl-terminal hydrolase L1 promotes hypoxia-inducible factor 1-dependent tumor cell malignancy in spheroid models. Ubiquitin carboxyl-terminal hydrolase L1 promotes hypoxia-inducible factor 1-dependent tumor cell malignancy in spheroid models. Cancer science, 111, 239-252 Cancer science, 111, 239-252 Cancer science, 111, 239-252 2019/11 Refereed English Research paper(scientific journal) Disclose to all
Koyasu S, Shimizu Y, Morinibu A, Saga T, Nakamoto Y, Togashi K, Harada H Koyasu S, Shimizu Y, Morinibu A, Saga T, Nakamoto Y, Togashi K, Harada H Koyasu S, Shimizu Y, Morinibu A, Saga T, Nakamoto Y, Togashi K, Harada H Increased <sup>14</sup>C-acetate accumulation in IDH-mutated human glioblastoma: implications for detecting IDH-mutated glioblastoma with <sup>11</sup>C-acetate PET imaging. Increased <sup>14</sup>C-acetate accumulation in IDH-mutated human glioblastoma: implications for detecting IDH-mutated glioblastoma with <sup>11</sup>C-acetate PET imaging. Increased <sup>14</sup>C-acetate accumulation in IDH-mutated human glioblastoma: implications for detecting IDH-mutated glioblastoma with <sup>11</sup>C-acetate PET imaging. Journal of neuro-oncology, 145, 3, 441-447 Journal of neuro-oncology, 145, 3, 441-447 Journal of neuro-oncology, 145, 3, 441-447 2019/10 Refereed English Research paper(scientific journal) Disclose to all
Ayako Nagao, Minoru Kobayashi, Sho Koyasu, Christalle C T Chow, Hiroshi Harada Ayako Nagao, Minoru Kobayashi, Sho Koyasu, Christalle C T Chow, Hiroshi Harada Ayako Nagao, Minoru Kobayashi, Sho Koyasu, Christalle C T Chow, Hiroshi Harada HIF-1-Dependent Reprogramming of Glucose Metabolic Pathway of Cancer Cells and Its Therapeutic Significance. HIF-1-Dependent Reprogramming of Glucose Metabolic Pathway of Cancer Cells and Its Therapeutic Significance. HIF-1-Dependent Reprogramming of Glucose Metabolic Pathway of Cancer Cells and Its Therapeutic Significance. International journal of molecular sciences, 20, 2, 238 International journal of molecular sciences, 20, 2, 238 International journal of molecular sciences, 20, 2, 238 2019/01/09 Refereed English Research paper(scientific journal) Disclose to all
原田 浩 原田 浩 酸素ホメオスタシス制御機構の解明と放射線治療効果増強への展開 酸素ホメオスタシス制御機構の解明と放射線治療効果増強への展開 放影協ニュース, 97, 10-11 放影協ニュース, 97, 10-11 , 97, 10-11 2018/10 Japanese Research paper(bulletin of university, research institution) Disclose to all
Masahiro Oe, Koji Miki, Huiying Mu, Hiroshi Harada, Akiyo Morinibu, Kouichi Ohe Masahiro Oe, Koji Miki, Huiying Mu, Hiroshi Harada, Akiyo Morinibu, Kouichi Ohe Masahiro Oe, Koji Miki, Huiying Mu, Hiroshi Harada, Akiyo Morinibu, Kouichi Ohe pH-Responsive Cy5 dyes having nucleophilic substituents for molecular imaging pH-Responsive Cy5 dyes having nucleophilic substituents for molecular imaging pH-Responsive Cy5 dyes having nucleophilic substituents for molecular imaging TETRAHEDRON LETTERS, 59, 35, 3317-3321 TETRAHEDRON LETTERS, 59, 35, 3317-3321 TETRAHEDRON LETTERS, 59, 35, 3317-3321 2018/08 Refereed English Research paper(scientific journal) Disclose to all
Sumi C, Okamoto A, Tanaka H, Kusunoki M, Shoji T, Uba T, Adachi T, Iwai T, Nishi K, Harada H, Bono H, Matsuo Y, Hirota K Sumi C, Okamoto A, Tanaka H, Kusunoki M, Shoji T, Uba T, Adachi T, Iwai T, Nishi K, Harada H, Bono H, Matsuo Y, Hirota K Sumi C, Okamoto A, Tanaka H, Kusunoki M, Shoji T, Uba T, Adachi T, Iwai T, Nishi K, Harada H, Bono H, Matsuo Y, Hirota K Suppression of mitochondrial oxygen metabolism mediated by the transcription factor HIF-1 alleviates propofol-induced cell toxicity. Suppression of mitochondrial oxygen metabolism mediated by the transcription factor HIF-1 alleviates propofol-induced cell toxicity. Suppression of mitochondrial oxygen metabolism mediated by the transcription factor HIF-1 alleviates propofol-induced cell toxicity. Scientific Reports, 8, 8987 Scientific Reports, 8, 8987 Scientific Reports, 8, 8987 2018/06 Refereed English Research paper(scientific journal) Disclose to all
Koyasu S, Kobayashi M, Goto Y, Hiraoka M, Harada H Koyasu S, Kobayashi M, Goto Y, Hiraoka M, Harada H Regulatory mechanisms of hypoxia-inducible factor 1 activity: Two decades of knowledge. Regulatory mechanisms of hypoxia-inducible factor 1 activity: Two decades of knowledge. Regulatory mechanisms of hypoxia-inducible factor 1 activity: Two decades of knowledge. Cancer Science, 109, 560-571 Cancer Science, 109, 560-571 Cancer Science, 109, 560-571 2018/03 Refereed English Research paper(scientific journal) Disclose to all
Katagiri T, Kobayashi M, Yoshimura M, Morinibu A, Itasaka S, Hiraoka M, Harada H Katagiri T, Kobayashi M, Yoshimura M, Morinibu A, Itasaka S, Hiraoka M, Harada H Katagiri T, Kobayashi M, Yoshimura M, Morinibu A, Itasaka S, Hiraoka M, Harada H HIF-1 maintains a functional relationship between pancreatic cancer cells and stromal fibroblasts by upregulating expression and secretion of Sonic hedgehog. HIF-1 maintains a functional relationship between pancreatic cancer cells and stromal fibroblasts by upregulating expression and secretion of Sonic hedgehog. HIF-1 maintains a functional relationship between pancreatic cancer cells and stromal fibroblasts by upregulating expression and secretion of Sonic hedgehog. Oncotarget, 9, 10525-10535 Oncotarget, 9, 10525-10535 Oncotarget, 9, 10525-10535 2018/01 Refereed English Research paper(scientific journal) Disclose to all
原田 浩 原田 浩 がん微小環境と低酸素 -HIF-1バイオロジーの視点から-. がん微小環境と低酸素 -HIF-1バイオロジーの視点から-. 月刊「細胞」, 50, 25-28 月刊「細胞」, 50, 25-28 , 50, 25-28 2018 Refereed Japanese Research paper(scientific journal) Disclose to all
Minoru Kobayashi, Akiyo Morinibu, Sho Koyasu, Yoko Goto, Masahiro Hiraoka, Hiroshi Harada Kobayashi M, Morinibu A, Koyasu S, Goto Y, Hiraoka M, Harada H Minoru Kobayashi, Akiyo Morinibu, Sho Koyasu, Yoko Goto, Masahiro Hiraoka, Hiroshi Harada A circadian clock gene, PER2, activates HIF-1 as an effector molecule for recruitment of HIF-1 alpha to promoter regions of its downstream genes A circadian clock gene, PER2, activates HIF-1 as an effector molecule for recruitment of HIF-1α to promoter regions of its downstream genes. A circadian clock gene, PER2, activates HIF-1 as an effector molecule for recruitment of HIF-1 alpha to promoter regions of its downstream genes FEBS JOURNAL, 284, 22, 3804-3816 FEBS Journal, 284, 22, 3804-3816 FEBS JOURNAL, 284, 22, 3804-3816 2017/11 Refereed English Research paper(scientific journal) Disclose to all
Yoko Goto, Sho Koyasu, Minoru Kobayashi, Hiroshi Harada Yoko Goto, Sho Koyasu, Minoru Kobayashi, Hiroshi Harada Yoko Goto, Sho Koyasu, Minoru Kobayashi, Hiroshi Harada The emerging roles of the ubiquitination/deubiquitination system in tumor radioresistance regarding DNA damage responses, cell cycle regulation, hypoxic responses, and antioxidant properties: Insight into the development of novel radiosensitizing strategies The emerging roles of the ubiquitination/deubiquitination system in tumor radioresistance regarding DNA damage responses, cell cycle regulation, hypoxic responses, and antioxidant properties: Insight into the development of novel radiosensitizing strategies The emerging roles of the ubiquitination/deubiquitination system in tumor radioresistance regarding DNA damage responses, cell cycle regulation, hypoxic responses, and antioxidant properties: Insight into the development of novel radiosensitizing strategies MUTATION RESEARCH-FUNDAMENTAL AND MOLECULAR MECHANISMS OF MUTAGENESIS, 803, 76-81 MUTATION RESEARCH-FUNDAMENTAL AND MOLECULAR MECHANISMS OF MUTAGENESIS, 803, 76-81 MUTATION RESEARCH-FUNDAMENTAL AND MOLECULAR MECHANISMS OF MUTAGENESIS, 803, 76-81 2017/10 Refereed English Research paper(scientific journal) Disclose to all
後藤容子, 中島良太, 原田浩 後藤容子, 中島良太, 原田浩 がん特異的グルコース代謝経路による放射線抵抗性と放射線治療増感への展開 がん特異的グルコース代謝経路による放射線抵抗性と放射線治療増感への展開 放射線生物研究, 52, 3, 277-290 放射線生物研究, 52, 3, 277-290 , 52, 3, 277-290 2017/09 Refereed Japanese Research paper(scientific journal) Disclose to all
Koji Miki, Kentaro Kojima, Kazuaki Oride, Hiroshi Harada, Akiyo Morinibu, Kouichi Ohe Koji Miki, Kentaro Kojima, Kazuaki Oride, Hiroshi Harada, Akiyo Morinibu, Kouichi Ohe Koji Miki, Kentaro Kojima, Kazuaki Oride, Hiroshi Harada, Akiyo Morinibu, Kouichi Ohe pH-Responsive near-infrared fluorescent cyanine dyes for molecular imaging based on pH sensing pH-Responsive near-infrared fluorescent cyanine dyes for molecular imaging based on pH sensing pH-Responsive near-infrared fluorescent cyanine dyes for molecular imaging based on pH sensing CHEMICAL COMMUNICATIONS, 53, 55, 7792-7795 CHEMICAL COMMUNICATIONS, 53, 55, 7792-7795 CHEMICAL COMMUNICATIONS, 53, 55, 7792-7795 2017/07 Refereed English Research paper(scientific journal) Disclose to all
Nakashima R, Goto Y, Koyasu S, Kobayashi M, Morinibu A, Yoshimura M, Hiraoka M, Hammond EM, Harada H Nakashima R, Goto Y, Koyasu S, Kobayashi M, Morinibu A, Yoshimura M, Hiraoka M, Hammond EM, Harada H Nakashima R, Goto Y, Koyasu S, Kobayashi M, Morinibu A, Yoshimura M, Hiraoka M, Hammond EM, Harada H UCHL1-HIF-1 axis-mediated antioxidant property of cancer cells as a therapeutic target for radiosensitization UCHL1-HIF-1 axis-mediated antioxidant property of cancer cells as a therapeutic target for radiosensitization UCHL1-HIF-1 axis-mediated antioxidant property of cancer cells as a therapeutic target for radiosensitization Scientific Reports, 7, 6879 Scientific Reports, 7, 6879 Scientific Reports, 7, 6879 2017/07 Refereed English Research paper(scientific journal) Disclose to all
Hiroshi Harada 原田 浩 Hiroshi Harada HIF-1 and Cancer Cell Metabolism HIF-1とがんの代謝 HIF-1 and Cancer Cell Metabolism Experimental Medicine, 35, 32-38 実験医学, 35, 32-38 Experimental Medicine, 35, 32-38 2017/06 Japanese Research paper(scientific journal) Disclose to all
Akihisa Okamoto, Chisato Sumi, Hiromasa Tanaka, Munenori Kusunoki, Teppei Iwai, Kenichiro Nishi, Yoshiyuki Matsuo, Hiroshi Harada, Keizo Takenaga, Hidemasa Bono, Kiichi Hirota Akihisa Okamoto, Chisato Sumi, Hiromasa Tanaka, Munenori Kusunoki, Teppei Iwai, Kenichiro Nishi, Yoshiyuki Matsuo, Hiroshi Harada, Keizo Takenaga, Hidemasa Bono, Kiichi Hirota Akihisa Okamoto, Chisato Sumi, Hiromasa Tanaka, Munenori Kusunoki, Teppei Iwai, Kenichiro Nishi, Yoshiyuki Matsuo, Hiroshi Harada, Keizo Takenaga, Hidemasa Bono, Kiichi Hirota HIF-1-mediated suppression of mitochondria electron transport chain function confers resistance to lidocaine-induced cell death HIF-1-mediated suppression of mitochondria electron transport chain function confers resistance to lidocaine-induced cell death HIF-1-mediated suppression of mitochondria electron transport chain function confers resistance to lidocaine-induced cell death SCIENTIFIC REPORTS, 7, 3816 SCIENTIFIC REPORTS, 7, 3816 SCIENTIFIC REPORTS, 7, 3816 2017/06 Refereed English Research paper(scientific journal) Disclose to all
原田 浩 原田 浩 放射線治療後のがんの再発メカニズム 放射線治療後のがんの再発メカニズム 次世代がん治療 次世代がん治療 2017 Refereed Japanese Disclose to all
Terumasa Sowa, Toshi Menju, Toyofumi F. Chen-Yoshikawa, Koji Takahashi, Shigeto Nishikawa, Takao Nakanishi, Kei Shikuma, Hideki Motoyama, Kyoko Hijiya, Akihiro Aoyama, Toshihiko Sato, Makoto Sonobe, Hiroshi Harada, Hiroshi Date Terumasa Sowa, Toshi Menju, Toyofumi F. Chen-Yoshikawa, Koji Takahashi, Shigeto Nishikawa, Takao Nakanishi, Kei Shikuma, Hideki Motoyama, Kyoko Hijiya, Akihiro Aoyama, Toshihiko Sato, Makoto Sonobe, Hiroshi Harada, Hiroshi Date Terumasa Sowa, Toshi Menju, Toyofumi F. Chen-Yoshikawa, Koji Takahashi, Shigeto Nishikawa, Takao Nakanishi, Kei Shikuma, Hideki Motoyama, Kyoko Hijiya, Akihiro Aoyama, Toshihiko Sato, Makoto Sonobe, Hiroshi Harada, Hiroshi Date Hypoxia-inducible factor 1 promotes chemoresistance of lung cancer by inducing carbonic anhydrase IX expression Hypoxia-inducible factor 1 promotes chemoresistance of lung cancer by inducing carbonic anhydrase IX expression Hypoxia-inducible factor 1 promotes chemoresistance of lung cancer by inducing carbonic anhydrase IX expression CANCER MEDICINE, 6, 1, 288-297 CANCER MEDICINE, 6, 1, 288-297 CANCER MEDICINE, 6, 1, 288-297 2017/01 Refereed English Research paper(scientific journal) Disclose to all
Chan Joo Yeom, Lihua Zeng, Yoko Goto, Akiyo Morinibu, Yuxi Zhu, Kazumi Shinomiya, Minoru Kobayashi, Satoshi Itasaka, Michio Yoshimura, Cheol-Goo Hur, Hideaki Kakeya, Ester M. Hammond, Masahiro Hiraoka, Hiroshi Harada Chan Joo Yeom, Lihua Zeng, Yoko Goto, Akiyo Morinibu, Yuxi Zhu, Kazumi Shinomiya, Minoru Kobayashi, Satoshi Itasaka, Michio Yoshimura, Cheol-Goo Hur, Hideaki Kakeya, Ester M. Hammond, Masahiro Hiraoka, Hiroshi Harada Chan Joo Yeom, Lihua Zeng, Yoko Goto, Akiyo Morinibu, Yuxi Zhu, Kazumi Shinomiya, Minoru Kobayashi, Satoshi Itasaka, Michio Yoshimura, Cheol-Goo Hur, Hideaki Kakeya, Ester M. Hammond, Masahiro Hiraoka, Hiroshi Harada LY6E: a conductor of malignant tumor growth through modulation of the PTEN/PI3K/Akt/HIF-1 axis LY6E: a conductor of malignant tumor growth through modulation of the PTEN/PI3K/Akt/HIF-1 axis LY6E: a conductor of malignant tumor growth through modulation of the PTEN/PI3K/Akt/HIF-1 axis ONCOTARGET, 7, 40, 65837-65848 ONCOTARGET, 7, 40, 65837-65848 ONCOTARGET, 7, 40, 65837-65848 2016/10 Refereed English Research paper(scientific journal) Disclose to all
Ryuji Yamaguchi, Hiroshi Harada, Kiichi Hirota Ryuji Yamaguchi, Hiroshi Harada, Kiichi Hirota Ryuji Yamaguchi, Hiroshi Harada, Kiichi Hirota VHL-deficient renal cancer cells gain resistance to mitochondria-activating apoptosis inducers by activating AKT through the IGF1R-PI3K pathway VHL-deficient renal cancer cells gain resistance to mitochondria-activating apoptosis inducers by activating AKT through the IGF1R-PI3K pathway VHL-deficient renal cancer cells gain resistance to mitochondria-activating apoptosis inducers by activating AKT through the IGF1R-PI3K pathway TUMOR BIOLOGY, 37, 10, 13295-13306 TUMOR BIOLOGY, 37, 10, 13295-13306 TUMOR BIOLOGY, 37, 10, 13295-13306 2016/10 Refereed English Research paper(scientific journal) Disclose to all
Hiroki Daijo, Yuma Hoshino, Shinichi Kai, Kengo Suzuki, Kenichiro Nishi, Yoshiyuki Matsuo, Hiroshi Harada, Kiichi Hirota Hiroki Daijo, Yuma Hoshino, Shinichi Kai, Kengo Suzuki, Kenichiro Nishi, Yoshiyuki Matsuo, Hiroshi Harada, Kiichi Hirota Hiroki Daijo, Yuma Hoshino, Shinichi Kai, Kengo Suzuki, Kenichiro Nishi, Yoshiyuki Matsuo, Hiroshi Harada, Kiichi Hirota Cigarette smoke reversibly activates hypoxia-inducible factor 1 in a reactive oxygen species-dependent manner Cigarette smoke reversibly activates hypoxia-inducible factor 1 in a reactive oxygen species-dependent manner Cigarette smoke reversibly activates hypoxia-inducible factor 1 in a reactive oxygen species-dependent manner SCIENTIFIC REPORTS, 6, 34424 SCIENTIFIC REPORTS, 6, 34424 SCIENTIFIC REPORTS, 6, 34424 2016/09 Refereed English Research paper(scientific journal) Disclose to all
Hiroshi Harada Hiroshi Harada Hiroshi Harada Hypoxia-inducible factor 1-mediated characteristic features of cancer cells for tumor radioresistance Hypoxia-inducible factor 1-mediated characteristic features of cancer cells for tumor radioresistance Hypoxia-inducible factor 1-mediated characteristic features of cancer cells for tumor radioresistance JOURNAL OF RADIATION RESEARCH, 57, I99-I105 JOURNAL OF RADIATION RESEARCH, 57, I99-I105 JOURNAL OF RADIATION RESEARCH, 57, I99-I105 2016/08 English Research paper(scientific journal) Disclose to all
Sho Koyasu, Yoshihisa Tsuji, Hiroshi Harada, Yuji Nakamoto, Tomomi Nobashi, Hiroyuki Kimura, Kohei Sano, Koji Koizumi, Masatsugu Hamaji, Kaori Togashi Sho Koyasu, Yoshihisa Tsuji, Hiroshi Harada, Yuji Nakamoto, Tomomi Nobashi, Hiroyuki Kimura, Kohei Sano, Koji Koizumi, Masatsugu Hamaji, Kaori Togashi Sho Koyasu, Yoshihisa Tsuji, Hiroshi Harada, Yuji Nakamoto, Tomomi Nobashi, Hiroyuki Kimura, Kohei Sano, Koji Koizumi, Masatsugu Hamaji, Kaori Togashi Evaluation of Tumor-associated Stroma and Its Relationship with Tumor Hypoxia Using Dynamic Contrast-enhanced CT and F-18 Misonidazole PET in Murine Tumor Models Evaluation of Tumor-associated Stroma and Its Relationship with Tumor Hypoxia Using Dynamic Contrast-enhanced CT and F-18 Misonidazole PET in Murine Tumor Models Evaluation of Tumor-associated Stroma and Its Relationship with Tumor Hypoxia Using Dynamic Contrast-enhanced CT and F-18 Misonidazole PET in Murine Tumor Models RADIOLOGY, 278, 3, 734-741 RADIOLOGY, 278, 3, 734-741 RADIOLOGY, 278, 3, 734-741 2016/03 Refereed English Research paper(scientific journal) Disclose to all
M. M. Olcina, K. B. Leszczynska, J. M. Senra, N. F. Isa, H. Harada, E. M. Hammond M. M. Olcina, K. B. Leszczynska, J. M. Senra, N. F. Isa, H. Harada, E. M. Hammond M. M. Olcina, K. B. Leszczynska, J. M. Senra, N. F. Isa, H. Harada, E. M. Hammond H3K9me3 facilitates hypoxia-induced p53-dependent apoptosis through repression of APAK H3K9me3 facilitates hypoxia-induced p53-dependent apoptosis through repression of APAK H3K9me3 facilitates hypoxia-induced p53-dependent apoptosis through repression of APAK ONCOGENE, 35, 6, 793-799 ONCOGENE, 35, 6, 793-799 ONCOGENE, 35, 6, 793-799 2016/02 Refereed English Research paper(scientific journal) Disclose to all
原田 浩 原田 浩 放射線によるシグナル伝達の変化 放射線によるシグナル伝達の変化 新版・放射線医科学, 29-31 新版・放射線医科学, 29-31 , 29-31 2016 Japanese Disclose to all
Arong Gaowa, Tomohisa Horibe, Masayuki Kohno, Hiroshi Harada, Masahiro Hiraoka, Koji Kawakami Arong Gaowa, Tomohisa Horibe, Masayuki Kohno, Hiroshi Harada, Masahiro Hiraoka, Koji Kawakami Arong Gaowa, Tomohisa Horibe, Masayuki Kohno, Hiroshi Harada, Masahiro Hiraoka, Koji Kawakami Potent anti-tumor effects of EGFR-targeted hybrid peptide on mice bearing liver metastases Potent anti-tumor effects of EGFR-targeted hybrid peptide on mice bearing liver metastases Potent anti-tumor effects of EGFR-targeted hybrid peptide on mice bearing liver metastases CLINICAL & EXPERIMENTAL METASTASIS, 33, 1, 87-95 CLINICAL & EXPERIMENTAL METASTASIS, 33, 1, 87-95 CLINICAL & EXPERIMENTAL METASTASIS, 33, 1, 87-95 2016/01 Refereed English Research paper(scientific journal) Disclose to all
Minoru Inoue, Michio Yoshimura, Minoru Kobayashi, Akiyo Morinibu, Satoshi Itasaka, Masahiro Hiraoka, Hiroshi Harada Minoru Inoue, Michio Yoshimura, Minoru Kobayashi, Akiyo Morinibu, Satoshi Itasaka, Masahiro Hiraoka, Hiroshi Harada Minoru Inoue, Michio Yoshimura, Minoru Kobayashi, Akiyo Morinibu, Satoshi Itasaka, Masahiro Hiraoka, Hiroshi Harada PLK1 blockade enhances therapeutic effects of radiation by inducing cell cycle arrest at the mitotic phase PLK1 blockade enhances therapeutic effects of radiation by inducing cell cycle arrest at the mitotic phase PLK1 blockade enhances therapeutic effects of radiation by inducing cell cycle arrest at the mitotic phase SCIENTIFIC REPORTS, 5, 15666 SCIENTIFIC REPORTS, 5, 15666 SCIENTIFIC REPORTS, 5, 15666 2015/10 Refereed English Research paper(scientific journal) Disclose to all
Shotaro Tanaka, Hiroshi Harada, Masahiro Hiraoka Shotaro Tanaka, Hiroshi Harada, Masahiro Hiraoka Shotaro Tanaka, Hiroshi Harada, Masahiro Hiraoka A novel method to visually determine the intracellular pH of xenografted tumor in vivo by utilizing fluorescent protein as an indicator A novel method to visually determine the intracellular pH of xenografted tumor in vivo by utilizing fluorescent protein as an indicator A novel method to visually determine the intracellular pH of xenografted tumor in vivo by utilizing fluorescent protein as an indicator BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 464, 4, 1151-1156 BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 464, 4, 1151-1156 BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 464, 4, 1151-1156 2015/09 Refereed English Research paper(scientific journal) Disclose to all
L. Zeng, A. Morinibu, M. Kobayashi, Y. Zhu, X. Wang, Y. Goto, C. J. Yeom, T. Zhao, K. Hirota, K. Shinomiya, S. Itasaka, M. Yoshimura, G. Guo, E. M. Hammond, M. Hiraoka, H. Harada L. Zeng, A. Morinibu, M. Kobayashi, Y. Zhu, X. Wang, Y. Goto, C. J. Yeom, T. Zhao, K. Hirota, K. Shinomiya, S. Itasaka, M. Yoshimura, G. Guo, E. M. Hammond, M. Hiraoka, H. Harada L. Zeng, A. Morinibu, M. Kobayashi, Y. Zhu, X. Wang, Y. Goto, C. J. Yeom, T. Zhao, K. Hirota, K. Shinomiya, S. Itasaka, M. Yoshimura, G. Guo, E. M. Hammond, M. Hiraoka, H. Harada Aberrant IDH3 alpha expression promotes malignant tumor growth by inducing HIF-1-mediated metabolic reprogramming and angiogenesis Aberrant IDH3 alpha expression promotes malignant tumor growth by inducing HIF-1-mediated metabolic reprogramming and angiogenesis Aberrant IDH3 alpha expression promotes malignant tumor growth by inducing HIF-1-mediated metabolic reprogramming and angiogenesis ONCOGENE, 34, 36, 4758-4766 ONCOGENE, 34, 36, 4758-4766 ONCOGENE, 34, 36, 4758-4766 2015/09 Refereed English Research paper(scientific journal) Disclose to all
Tomonori Matsuyama, Tomoharu Tanaka, Kenichiro Tatsumi, Hiroki Daijo, Shinichi Kai, Hiroshi Harada, Kazuhiko Fukuda Tomonori Matsuyama, Tomoharu Tanaka, Kenichiro Tatsumi, Hiroki Daijo, Shinichi Kai, Hiroshi Harada, Kazuhiko Fukuda Tomonori Matsuyama, Tomoharu Tanaka, Kenichiro Tatsumi, Hiroki Daijo, Shinichi Kai, Hiroshi Harada, Kazuhiko Fukuda Midazolam inhibits the hypoxia-induced up-regulation of erythropoietin in the central nervous system Midazolam inhibits the hypoxia-induced up-regulation of erythropoietin in the central nervous system Midazolam inhibits the hypoxia-induced up-regulation of erythropoietin in the central nervous system EUROPEAN JOURNAL OF PHARMACOLOGY, 761, 189-198 EUROPEAN JOURNAL OF PHARMACOLOGY, 761, 189-198 EUROPEAN JOURNAL OF PHARMACOLOGY, 761, 189-198 2015/08 Refereed English Research paper(scientific journal) Disclose to all
Koji Miki, Akinori Kimura, Tatsuhiro Inoue, Hideki Matsuoka, Hiroshi Harada, Masahiro Hiraoka, Kouichi Ohe Koji Miki, Akinori Kimura, Tatsuhiro Inoue, Hideki Matsuoka, Hiroshi Harada, Masahiro Hiraoka, Kouichi Ohe Koji Miki, Akinori Kimura, Tatsuhiro Inoue, Hideki Matsuoka, Hiroshi Harada, Masahiro Hiraoka, Kouichi Ohe Synthesis of Biocompatible Polysaccharide Analogues and Their Application to In Vivo Optical Tumor Imaging Synthesis of Biocompatible Polysaccharide Analogues and Their Application to In Vivo Optical Tumor Imaging Synthesis of Biocompatible Polysaccharide Analogues and Their Application to In Vivo Optical Tumor Imaging BULLETIN OF THE CHEMICAL SOCIETY OF JAPAN, 88, 6, 792-803 BULLETIN OF THE CHEMICAL SOCIETY OF JAPAN, 88, 6, 792-803 BULLETIN OF THE CHEMICAL SOCIETY OF JAPAN, 88, 6, 792-803 2015/06 Refereed English Research paper(scientific journal) Disclose to all
Arong Gaowa, Tomohisa Horibe, Masayuki Kohno, Yasuhiko Tabata, Hiroshi Harada, Masahiro Hiraoka, Koji Kawakami Arong Gaowa, Tomohisa Horibe, Masayuki Kohno, Yasuhiko Tabata, Hiroshi Harada, Masahiro Hiraoka, Koji Kawakami Arong Gaowa, Tomohisa Horibe, Masayuki Kohno, Yasuhiko Tabata, Hiroshi Harada, Masahiro Hiraoka, Koji Kawakami Enhancement of anti-tumor activity of hybrid peptide in conjugation with carboxymethyl dextran via disulfide linkers Enhancement of anti-tumor activity of hybrid peptide in conjugation with carboxymethyl dextran via disulfide linkers Enhancement of anti-tumor activity of hybrid peptide in conjugation with carboxymethyl dextran via disulfide linkers EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS, 92, 228-236 EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS, 92, 228-236 EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS, 92, 228-236 2015/05 Refereed English Research paper(scientific journal) Disclose to all
後藤容子, 平岡真寛, 原田浩 後藤容子, 平岡真寛, 原田浩 低酸素シグナル 低酸素シグナル 生体の化学, 66, 394-395 生体の化学, 66, 394-395 , 66, 394-395 2015 Japanese Disclose to all
Yoko Goto, Lihua Zeng, Chan Joo Yeom, Yuxi Zhu, Akiyo Morinibu, Kazumi Shinomiya, Minoru Kobayashi, Kiichi Hirota, Satoshi Itasaka, Michio Yoshimura, Keiji Tanimoto, Masae Torii, Terumasa Sowa, Toshi Menju, Makoto Sonobe, Hideaki Kakeya, Masakazu Toi, Hiroshi Date, Ester M. Hammond, Masahiro Hiraoka, Hiroshi Harada Goto Y, Zeng L, Yeom CJ, Zhu Y, Morinibu A, Shinomiya K, Kobayashi M, Hirota K, Itasaka S, Yoshimura m, Tanimoto K, Torii M, Sowa T, Menju T, Sonobe M, Kakeya H, Toi M, Date H, Hammond EM, Hiraoka M, Harada H Yoko Goto, Lihua Zeng, Chan Joo Yeom, Yuxi Zhu, Akiyo Morinibu, Kazumi Shinomiya, Minoru Kobayashi, Kiichi Hirota, Satoshi Itasaka, Michio Yoshimura, Keiji Tanimoto, Masae Torii, Terumasa Sowa, Toshi Menju, Makoto Sonobe, Hideaki Kakeya, Masakazu Toi, Hiroshi Date, Ester M. Hammond, Masahiro Hiraoka, Hiroshi Harada UCHL1 provides diagnostic and antimetastatic strategies due to its deubiquitinating effect on HIF-1 alpha UCHL1 provides diagnostic and antimetastatic strategies due to its deubiquitinating effect on ​HIF-1α UCHL1 provides diagnostic and antimetastatic strategies due to its deubiquitinating effect on HIF-1 alpha Nature Communications, 6, 6153 Nature Communications, 6, 6153 Nature Communications, 6, 6153 2015/01 Refereed English Research paper(scientific journal) Disclose to all
Jason Boyang Wu, Chen Shao, Xiangyan Li, Changhong Shi, Qinlong Li, Peizhen Hu, Yi-Ting Chen, Xiaoliang Dou, Divya Sahu, Wei Li, Hiroshi Harada, Yi Zhang, Ruoxiang Wang, Haiyen E. Zhau, Leland W. K. Chung WU Jason Boyang, SHAO Chen, SHAO Chen, LI Xiangyan, SHI Changhong, SHI Changhong, LI Qinlong, HU Peizhen, CHEN Yi-ting, DOU Xiaoliang, SAHU Divya, LI Wei, HARADA Hiroshi, ZHANG Yi, ZHANG Yi, WANG Ruoxiang, ZHAU Haiyen E, CHUNG Leland W.K Jason Boyang Wu, Chen Shao, Xiangyan Li, Changhong Shi, Qinlong Li, Peizhen Hu, Yi-Ting Chen, Xiaoliang Dou, Divya Sahu, Wei Li, Hiroshi Harada, Yi Zhang, Ruoxiang Wang, Haiyen E. Zhau, Leland W. K. Chung Near-infrared fluorescence imaging of cancer mediated by tumor hypoxia and HIFI alpha/OATPs signaling axis Near-infraredfluorescence imaging of cancer mediated by tumor hypoxia and HIF1α/OATPs signaling axis. Near-infrared fluorescence imaging of cancer mediated by tumor hypoxia and HIFI alpha/OATPs signaling axis BIOMATERIALS, 35, 28, 8175-8185 Biomaterials, 35, 28, 8175-8185 BIOMATERIALS, 35, 28, 8175-8185 2014/09 Refereed English Research paper(scientific journal) Disclose to all
Koji Miki, Hiroki Hashimoto, Tatsuhiro Inoue, Hideki Matsuoka, Hiroshi Harada, Masahiro Hiraoka, Kouichi Ohe Koji Miki, Hiroki Hashimoto, Tatsuhiro Inoue, Hideki Matsuoka, Hiroshi Harada, Masahiro Hiraoka, Kouichi Ohe Koji Miki, Hiroki Hashimoto, Tatsuhiro Inoue, Hideki Matsuoka, Hiroshi Harada, Masahiro Hiraoka, Kouichi Ohe Sonication-Induced Formation of Size-Controlled Self-Assemblies of Amphiphilic Janus-Type Polymers as Optical Tumor-Imaging Agents Sonication-Induced Formation of Size-Controlled Self-Assemblies of Amphiphilic Janus-Type Polymers as Optical Tumor-Imaging Agents Sonication-Induced Formation of Size-Controlled Self-Assemblies of Amphiphilic Janus-Type Polymers as Optical Tumor-Imaging Agents SMALL, 10, 15, 3119-3130 SMALL, 10, 15, 3119-3130 SMALL, 10, 15, 3119-3130 2014/08 Refereed English Research paper(scientific journal) Disclose to all
Ken Ohnishi, Toshiaki Tani, Shin-Ichi Bando, Nobuo Kubota, Yoshihiro Fujii, Osamu Hatano, Hirosi Harada Ken Ohnishi, Toshiaki Tani, Shin-Ichi Bando, Nobuo Kubota, Yoshihiro Fujii, Osamu Hatano, Hirosi Harada Ken Ohnishi, Toshiaki Tani, Shin-Ichi Bando, Nobuo Kubota, Yoshihiro Fujii, Osamu Hatano, Hirosi Harada Plastic induction of CD133(AC133)-positive cells in the microenvironment of glioblastoma spheroids Plastic induction of CD133(AC133)-positive cells in the microenvironment of glioblastoma spheroids Plastic induction of CD133(AC133)-positive cells in the microenvironment of glioblastoma spheroids INTERNATIONAL JOURNAL OF ONCOLOGY, 45, 2, 581-586 INTERNATIONAL JOURNAL OF ONCOLOGY, 45, 2, 581-586 INTERNATIONAL JOURNAL OF ONCOLOGY, 45, 2, 581-586 2014/08 Refereed English Research paper(scientific journal) Disclose to all
Koyasu Sho, Nakamoto Yuji, Harada Hiroshi, Kimura Hiroyuki, Sano Kohei, Koizumi Koji, Tsuji Yoshihisa, Nobashi Tomomi, Kurihara Kensuke, Togashi Kaori Koyasu Sho, Nakamoto Yuji, Harada Hiroshi, Kimura Hiroyuki, Sano Kohei, Koizumi Koji, Tsuji Yoshihisa, Nobashi Tomomi, Kurihara Kensuke, Togashi Kaori Koyasu Sho, Nakamoto Yuji, Harada Hiroshi, Kimura Hiroyuki, Sano Kohei, Koizumi Koji, Tsuji Yoshihisa, Nobashi Tomomi, Kurihara Kensuke, Togashi Kaori Evaluation of intratumoral microenvironment with 18F-misonidazole PET and dynamic contrast enhanced CT in tumor-bearing mice models Evaluation of intratumoral microenvironment with 18F-misonidazole PET and dynamic contrast enhanced CT in tumor-bearing mice models Evaluation of intratumoral microenvironment with 18F-misonidazole PET and dynamic contrast enhanced CT in tumor-bearing mice models JOURNAL OF NUCLEAR MEDICINE, 55 JOURNAL OF NUCLEAR MEDICINE, 55 JOURNAL OF NUCLEAR MEDICINE, 55 2014/05 Refereed Disclose to all
Arong Gaowa, Tomohisa Horibe, Masayuki Kohno, Keisuke Sato, Hiroshi Harada, Masahiro Hiraoka, Yasuhiko Tabata, Koji Kawakami Arong Gaowa, Tomohisa Horibe, Masayuki Kohno, Keisuke Sato, Hiroshi Harada, Masahiro Hiraoka, Yasuhiko Tabata, Koji Kawakami Arong Gaowa, Tomohisa Horibe, Masayuki Kohno, Keisuke Sato, Hiroshi Harada, Masahiro Hiraoka, Yasuhiko Tabata, Koji Kawakami Combination of hybrid peptide with biodegradable gelatin hydrogel for controlled release and enhancement of anti-tumor activity in vivo Combination of hybrid peptide with biodegradable gelatin hydrogel for controlled release and enhancement of anti-tumor activity in vivo Combination of hybrid peptide with biodegradable gelatin hydrogel for controlled release and enhancement of anti-tumor activity in vivo JOURNAL OF CONTROLLED RELEASE, 176, 1-7 JOURNAL OF CONTROLLED RELEASE, 176, 1-7 JOURNAL OF CONTROLLED RELEASE, 176, 1-7 2014/02 Refereed English Research paper(scientific journal) Disclose to all
Tao Zhao, Yuxi Zhu, Akiyo Morinibu, Minoru Kobayashi, Kazumi Shinomiya, Satoshi Itasaka, Michio Yoshimura, Guozheng Guo, Masahiro Hiraoka, Hiroshi Harada Tao Zhao, Yuxi Zhu, Akiyo Morinibu, Minoru Kobayashi, Kazumi Shinomiya, Satoshi Itasaka, Michio Yoshimura, Guozheng Guo, Masahiro Hiraoka, Hiroshi Harada Tao Zhao, Yuxi Zhu, Akiyo Morinibu, Minoru Kobayashi, Kazumi Shinomiya, Satoshi Itasaka, Michio Yoshimura, Guozheng Guo, Masahiro Hiraoka, Hiroshi Harada HIF-1-mediated metabolic reprogramming reduces ROS levels and facilitates the metastatic colonization of cancers in lungs HIF-1-mediated metabolic reprogramming reduces ROS levels and facilitates the metastatic colonization of cancers in lungs HIF-1-mediated metabolic reprogramming reduces ROS levels and facilitates the metastatic colonization of cancers in lungs SCIENTIFIC REPORTS, 4, 3793 SCIENTIFIC REPORTS, 4, 3793 SCIENTIFIC REPORTS, 4, 3793 2014/01 Refereed English Research paper(scientific journal) Disclose to all
Y. Zhu, T. Zhao, S. Itasaka, L. Zeng, C. J. Yeom, K. Hirota, K. Suzuki, A. Morinibu, K. Shinomiya, G. Ou, M. Yoshimura, M. Hiraoka, H. Harada Y. Zhu, T. Zhao, S. Itasaka, L. Zeng, C. J. Yeom, K. Hirota, K. Suzuki, A. Morinibu, K. Shinomiya, G. Ou, M. Yoshimura, M. Hiraoka, H. Harada Y. Zhu, T. Zhao, S. Itasaka, L. Zeng, C. J. Yeom, K. Hirota, K. Suzuki, A. Morinibu, K. Shinomiya, G. Ou, M. Yoshimura, M. Hiraoka, H. Harada Involvement of decreased hypoxia-inducible factor 1 activity and resultant G(1)-S cell cycle transition in radioresistance of perinecrotic tumor cells Involvement of decreased hypoxia-inducible factor 1 activity and resultant G(1)-S cell cycle transition in radioresistance of perinecrotic tumor cells Involvement of decreased hypoxia-inducible factor 1 activity and resultant G(1)-S cell cycle transition in radioresistance of perinecrotic tumor cells ONCOGENE, 32, 16, 2058-2068 ONCOGENE, 32, 16, 2058-2068 ONCOGENE, 32, 16, 2058-2068 2013/04 Refereed English Research paper(scientific journal) Disclose to all
Mari Fujita, Hiroyuki Sasanuma, Kimiyo N. Yamamoto, Hiroshi Harada, Aya Kurosawa, Noritaka Adachi, Masato Omura, Masahiro Hiraoka, Shunichi Takeda, Kouji Hirota Mari Fujita, Hiroyuki Sasanuma, Kimiyo N. Yamamoto, Hiroshi Harada, Aya Kurosawa, Noritaka Adachi, Masato Omura, Masahiro Hiraoka, Shunichi Takeda, Kouji Hirota Mari Fujita, Hiroyuki Sasanuma, Kimiyo N. Yamamoto, Hiroshi Harada, Aya Kurosawa, Noritaka Adachi, Masato Omura, Masahiro Hiraoka, Shunichi Takeda, Kouji Hirota Interference in DNA Replication Can Cause Mitotic Chromosomal Breakage Unassociated with Double-Strand Breaks Interference in DNA Replication Can Cause Mitotic Chromosomal Breakage Unassociated with Double-Strand Breaks Interference in DNA Replication Can Cause Mitotic Chromosomal Breakage Unassociated with Double-Strand Breaks PLOS ONE, 8, 4, e60043 PLOS ONE, 8, 4, e60043 PLOS ONE, 8, 4, e60043 2013/04 Refereed English Research paper(scientific journal) Disclose to all
Harada H, Inoue M, Itasaka S, Hirota K, Morinibu A, Shinomiya K, Zeng L, Ou G, Zhu Y, Yoshimura M, McKenna W.G, Muschel R.J, Hiraoka M Harada H, Inoue M, Itasaka S, Hirota K, Morinibu A, Shinomiya K, Zeng L, Ou G, Zhu Y, Yoshimura M, McKenna W.G, Muschel R.J, Hiraoka M Harada H, Inoue M, Itasaka S, Hirota K, Morinibu A, Shinomiya K, Zeng L, Ou G, Zhu Y, Yoshimura M, McKenna W.G, Muschel R.J, Hiraoka M Erratum: Cancer cells that survive radiation therapy acquire HIF-1 activity and translocate toward tumour blood vessels (Nature Communications (2012) 3 (783) doi: 10.1038/ncomms1786) Erratum: Cancer cells that survive radiation therapy acquire HIF-1 activity and translocate toward tumour blood vessels (Nature Communications (2012) 3 (783) doi: 10.1038/ncomms1786) Erratum: Cancer cells that survive radiation therapy acquire HIF-1 activity and translocate toward tumour blood vessels (Nature Communications (2012) 3 (783) doi: 10.1038/ncomms1786) Nature Communications, 4 Nature Communications, 4 Nature Communications, 4 2013 Refereed Disclose to all
小林稔, 原田浩 小林稔, 原田浩 低酸素ストレスとHIF 低酸素ストレスとHIF 生化学. 85:187-195. 2013. 生化学. 85:187-195. 2013. 2013 Japanese Disclose to all
Michio Yoshimura, Satoshi Itasaka, Hiroshi Harada, Masahiro Hiraoka Michio Yoshimura, Satoshi Itasaka, Hiroshi Harada, Masahiro Hiraoka Michio Yoshimura, Satoshi Itasaka, Hiroshi Harada, Masahiro Hiraoka Microenvironment and Radiation Therapy Microenvironment and Radiation Therapy Microenvironment and Radiation Therapy BIOMED RESEARCH INTERNATIONAL, 2013, 685308 BIOMED RESEARCH INTERNATIONAL, 2013, 685308 BIOMED RESEARCH INTERNATIONAL, 2013, 685308 2013 Refereed English Disclose to all
Koji Miki, Katsuya Nakano, Hideki Matsuoka, Chan Joo Yeom, Hiroshi Harada, Masahiro Hiraoka, Kouichi Ohe Koji Miki, Katsuya Nakano, Hideki Matsuoka, Chan Joo Yeom, Hiroshi Harada, Masahiro Hiraoka, Kouichi Ohe Koji Miki, Katsuya Nakano, Hideki Matsuoka, Chan Joo Yeom, Hiroshi Harada, Masahiro Hiraoka, Kouichi Ohe Amphiphilic Brush-Like Copolymers Involving Hydrophobic Amino Acid- and Oligopeptide-Side Chains for Optical Tumor Imaging In Vivo Amphiphilic Brush-Like Copolymers Involving Hydrophobic Amino Acid- and Oligopeptide-Side Chains for Optical Tumor Imaging In Vivo Amphiphilic Brush-Like Copolymers Involving Hydrophobic Amino Acid- and Oligopeptide-Side Chains for Optical Tumor Imaging In Vivo BULLETIN OF THE CHEMICAL SOCIETY OF JAPAN, 85, 12, 1277-1286 BULLETIN OF THE CHEMICAL SOCIETY OF JAPAN, 85, 12, 1277-1286 BULLETIN OF THE CHEMICAL SOCIETY OF JAPAN, 85, 12, 1277-1286 2012/12 Refereed English Research paper(scientific journal) Disclose to all
原田浩 原田浩 がんの再発機構が示すPETイメージングの方向性 がんの再発機構が示すPETイメージングの方向性 Isotope news, 703, 2-7 Isotope news, 703, 2-7 , 703, 2-7 2012/11/01 Japanese Disclose to all
Chan Joo Yeom, Yoko Goto, Yuxi Zhu, Masahiro Hiraoka, Hiroshi Harada Chan Joo Yeom, Yoko Goto, Yuxi Zhu, Masahiro Hiraoka, Hiroshi Harada Chan Joo Yeom, Yoko Goto, Yuxi Zhu, Masahiro Hiraoka, Hiroshi Harada Microenvironments and Cellular Characteristics in the Micro Tumor Cords of Malignant Solid Tumors Microenvironments and Cellular Characteristics in the Micro Tumor Cords of Malignant Solid Tumors Microenvironments and Cellular Characteristics in the Micro Tumor Cords of Malignant Solid Tumors INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, 13, 11, 13949-13965 INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, 13, 11, 13949-13965 INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, 13, 11, 13949-13965 2012/11 Refereed English Disclose to all
原田 浩, 後藤 容子, 井上 実 原田 浩, 後藤 容子, 井上 実 放射線治療における低酸素イメージングの有用性 : 放射線生物学の見地から (特集 画像誘導放射線治療の進歩) 放射線治療における低酸素イメージングの有用性 : 放射線生物学の見地から (特集 画像誘導放射線治療の進歩) 臨床放射線, 57, 4, 518-526 臨床放射線, 57, 4, 518-526 , 57, 4, 518-526 2012/04 Japanese Disclose to all
Hiroshi Harada, Masahiro Inoue, Satoshi Itasaka, Kiichi Hirota, Akiyo Morinibu, Kazumi Shinomiya, Lihua Zeng, Guangfei Ou, Yuxi Zhu, Michio Yoshimura, W. Gillies McKenna, Ruth J. Muschel, Masahiro Hiraoka Hiroshi Harada, Masahiro Inoue, Satoshi Itasaka, Kiichi Hirota, Akiyo Morinibu, Kazumi Shinomiya, Lihua Zeng, Guangfei Ou, Yuxi Zhu, Michio Yoshimura, W. Gillies McKenna, Ruth J. Muschel, Masahiro Hiraoka Hiroshi Harada, Masahiro Inoue, Satoshi Itasaka, Kiichi Hirota, Akiyo Morinibu, Kazumi Shinomiya, Lihua Zeng, Guangfei Ou, Yuxi Zhu, Michio Yoshimura, W. Gillies McKenna, Ruth J. Muschel, Masahiro Hiraoka Cancer cells that survive radiation therapy acquire HIF-1 activity and translocate towards tumour blood vessels Cancer cells that survive radiation therapy acquire HIF-1 activity and translocate towards tumour blood vessels Cancer cells that survive radiation therapy acquire HIF-1 activity and translocate towards tumour blood vessels NATURE COMMUNICATIONS, 3 NATURE COMMUNICATIONS, 3 NATURE COMMUNICATIONS, 3 2012/04 Refereed English Research paper(scientific journal) Disclose to all
Shinichi Kai, Tomoharu Tanaka, Hiroki Daijo, Hiroshi Harada, Shun Kishimoto, Kengo Suzuki, Satoshi Takabuchi, Keizo Takenaga, Kazuhiko Fukuda, Kiichi Hirota Shinichi Kai, Tomoharu Tanaka, Hiroki Daijo, Hiroshi Harada, Shun Kishimoto, Kengo Suzuki, Satoshi Takabuchi, Keizo Takenaga, Kazuhiko Fukuda, Kiichi Hirota Shinichi Kai, Tomoharu Tanaka, Hiroki Daijo, Hiroshi Harada, Shun Kishimoto, Kengo Suzuki, Satoshi Takabuchi, Keizo Takenaga, Kazuhiko Fukuda, Kiichi Hirota Hydrogen Sulfide Inhibits Hypoxia- But Not Anoxia-Induced Hypoxia-Inducible Factor 1 Activation in a von Hippel-Lindau- and Mitochondria-Dependent Manner Hydrogen Sulfide Inhibits Hypoxia- But Not Anoxia-Induced Hypoxia-Inducible Factor 1 Activation in a von Hippel-Lindau- and Mitochondria-Dependent Manner Hydrogen Sulfide Inhibits Hypoxia- But Not Anoxia-Induced Hypoxia-Inducible Factor 1 Activation in a von Hippel-Lindau- and Mitochondria-Dependent Manner ANTIOXIDANTS & REDOX SIGNALING, 16, 3, 203-216 ANTIOXIDANTS & REDOX SIGNALING, 16, 3, 203-216 ANTIOXIDANTS & REDOX SIGNALING, 16, 3, 203-216 2012/02 Refereed English Research paper(scientific journal) Disclose to all
Harada H, Itasaka S, Yoshimura M, Ogura M, Masunaga, Hiraoka M Harada H, Itasaka S, Yoshimura M, Ogura M, Masunaga, Hiraoka M Harada H, Itasaka S, Yoshimura M, Ogura M, Masunaga, Hiraoka M A biological mechanism behind the radioresistance of hypoxic tumor cells. A biological mechanism behind the radioresistance of hypoxic tumor cells. A biological mechanism behind the radioresistance of hypoxic tumor cells. KURRI Progress Report, 2011, 104-0 KURRI Progress Report, 2011, 104-0 KURRI Progress Report, 2011, 104-0 2012 English Disclose to all
原田浩 原田浩 HIFとその調節系 HIFとその調節系 日本臨牀増刊号:分子標的. 70:113-117. 2012. 日本臨牀増刊号:分子標的. 70:113-117. 2012. 2012 Japanese Disclose to all
田邉一仁, 原田浩, 平岡真寛, 西本清一 田邉一仁, 原田浩, 平岡真寛, 西本清一 細胞内還元反応を活用した低酸素環境イメージング 細胞内還元反応を活用した低酸素環境イメージング 実験医学 30:89-95.2012. 実験医学 30:89-95.2012. 2012 Japanese Disclose to all
Koji Miki, Kazuaki Oride, Akinori Kimura, Yoshiaki Kuramochi, Hideki Matsuoka, Hiroshi Harada, Masahiro Hiraoka, Kouichi Ohe Koji Miki, Kazuaki Oride, Akinori Kimura, Yoshiaki Kuramochi, Hideki Matsuoka, Hiroshi Harada, Masahiro Hiraoka, Kouichi Ohe Koji Miki, Kazuaki Oride, Akinori Kimura, Yoshiaki Kuramochi, Hideki Matsuoka, Hiroshi Harada, Masahiro Hiraoka, Kouichi Ohe Influence of Side Chain Length on Fluorescence Intensity of ROMP-Based Polymeric Nanoparticles and Their Tumor Specificity in In-Vivo Tumor Imaging Influence of Side Chain Length on Fluorescence Intensity of ROMP-Based Polymeric Nanoparticles and Their Tumor Specificity in In-Vivo Tumor Imaging Influence of Side Chain Length on Fluorescence Intensity of ROMP-Based Polymeric Nanoparticles and Their Tumor Specificity in In-Vivo Tumor Imaging SMALL, 7, 24, 3536-3547 SMALL, 7, 24, 3536-3547 SMALL, 7, 24, 3536-3547 2011/12 Refereed English Research paper(scientific journal) Disclose to all
Akira Makino, Hiroshi Harada, Tomohisa Okada, Hiroyuki Kimura, Hiroo Amano, Hideo Saji, Masahiro Hiraoka, Shunsaku Kimura Akira Makino, Hiroshi Harada, Tomohisa Okada, Hiroyuki Kimura, Hiroo Amano, Hideo Saji, Masahiro Hiraoka, Shunsaku Kimura Akira Makino, Hiroshi Harada, Tomohisa Okada, Hiroyuki Kimura, Hiroo Amano, Hideo Saji, Masahiro Hiraoka, Shunsaku Kimura Effective encapsulation of a new cationic gadolinium chelate into apoferritin and its evaluation as an MRI contrast agent Effective encapsulation of a new cationic gadolinium chelate into apoferritin and its evaluation as an MRI contrast agent Effective encapsulation of a new cationic gadolinium chelate into apoferritin and its evaluation as an MRI contrast agent NANOMEDICINE-NANOTECHNOLOGY BIOLOGY AND MEDICINE, 7, 5, 638-646 NANOMEDICINE-NANOTECHNOLOGY BIOLOGY AND MEDICINE, 7, 5, 638-646 NANOMEDICINE-NANOTECHNOLOGY BIOLOGY AND MEDICINE, 7, 5, 638-646 2011/10 Refereed English Research paper(scientific journal) Disclose to all
Debabrata Saha, Henry Dunn, Heling Zhou, Hiroshi Harada, Masahiro Hiraoka, Ralph P. Mason, Dawen Zhao Debabrata Saha, Henry Dunn, Heling Zhou, Hiroshi Harada, Masahiro Hiraoka, Ralph P. Mason, Dawen Zhao Debabrata Saha, Henry Dunn, Heling Zhou, Hiroshi Harada, Masahiro Hiraoka, Ralph P. Mason, Dawen Zhao In vivo Bioluminescence Imaging of Tumor Hypoxia Dynamics of Breast Cancer Brain Metastasis in a Mouse Model In vivo Bioluminescence Imaging of Tumor Hypoxia Dynamics of Breast Cancer Brain Metastasis in a Mouse Model In vivo Bioluminescence Imaging of Tumor Hypoxia Dynamics of Breast Cancer Brain Metastasis in a Mouse Model JOVE-JOURNAL OF VISUALIZED EXPERIMENTS, 56 JOVE-JOURNAL OF VISUALIZED EXPERIMENTS, 56 JOVE-JOURNAL OF VISUALIZED EXPERIMENTS, 56 2011/10 Refereed English Research paper(scientific journal) Disclose to all
Debabrata Saha, Henry Dunn, Heling Zhou, Hiroshi Harada, Masahiro Hiraoka, Ralph P. Mason, Dawen Zhao Debabrata Saha, Henry Dunn, Heling Zhou, Hiroshi Harada, Masahiro Hiraoka, Ralph P. Mason, Dawen Zhao Debabrata Saha, Henry Dunn, Heling Zhou, Hiroshi Harada, Masahiro Hiraoka, Ralph P. Mason, Dawen Zhao In vivo Bioluminescence Imaging of Tumor Hypoxia Dynamics of Breast Cancer Brain Metastasis in a Mouse Model In vivo Bioluminescence Imaging of Tumor Hypoxia Dynamics of Breast Cancer Brain Metastasis in a Mouse Model In vivo Bioluminescence Imaging of Tumor Hypoxia Dynamics of Breast Cancer Brain Metastasis in a Mouse Model JOVE-JOURNAL OF VISUALIZED EXPERIMENTS, 56 JOVE-JOURNAL OF VISUALIZED EXPERIMENTS, 56 JOVE-JOURNAL OF VISUALIZED EXPERIMENTS, 56 2011/10 Refereed English Research paper(scientific journal) Disclose to all
Hiroki Daijo, Shinichi Kai, Tomoharu Tanaka, Takuhiko Wakamatsu, Shun Kishimoto, Kengo Suzuki, Hiroshi Harada, Satoshi Takabuchi, Takehiko Adachi, Kazuhiko Fukuda, Kiichi Hirota H. Daijo, S. Kai, T. Tanaka, T. Wakamatsu, S. Kishimoto, K. Suzuki, H. Harada, S. Takabuchi, T. Adachi, K. Fukuda, K. Hirota Hiroki Daijo, Shinichi Kai, Tomoharu Tanaka, Takuhiko Wakamatsu, Shun Kishimoto, Kengo Suzuki, Hiroshi Harada, Satoshi Takabuchi, Takehiko Adachi, Kazuhiko Fukuda, Kiichi Hirota Fentanyl activates hypoxia-inducible factor 1 in neuronal SH-SY5Y cells and mice under non-hypoxic conditions in a mu-opioid receptor-dependent manner Fentanyl activates hypoxia-inducible factor 1 in neuronal SH-SY5Y cells and mice under non-hypoxic conditions in a μ-opioid receptor-dependent manner Fentanyl activates hypoxia-inducible factor 1 in neuronal SH-SY5Y cells and mice under non-hypoxic conditions in a mu-opioid receptor-dependent manner EUROPEAN JOURNAL OF PHARMACOLOGY, 667, 1-3, 144-152 European Journal of Pharmacology, 667, 1-3, 144-152 EUROPEAN JOURNAL OF PHARMACOLOGY, 667, 1-3, 144-152 2011/09 Refereed English Research paper(scientific journal) Disclose to all
Hiroshi Harada Hiroshi Harada Hiroshi Harada How Can We Overcome Tumor Hypoxia in Radiation Therapy? How Can We Overcome Tumor Hypoxia in Radiation Therapy? How Can We Overcome Tumor Hypoxia in Radiation Therapy? JOURNAL OF RADIATION RESEARCH, 52, 5, 545-556 JOURNAL OF RADIATION RESEARCH, 52, 5, 545-556 JOURNAL OF RADIATION RESEARCH, 52, 5, 545-556 2011/09 Refereed English Research paper(scientific journal) Disclose to all
Takakuni Maki, Masafumi Ihara, Youshi Fujita, Takuo Nambu, Hiroshi Harada, Hidefumi Ito, Kazuwa Nakao, Hidekazu Tomimoto, Ryosuke Takahashi Takakuni Maki, Masafumi Ihara, Youshi Fujita, Takuo Nambu, Hiroshi Harada, Hidefumi Ito, Kazuwa Nakao, Hidekazu Tomimoto, Ryosuke Takahashi Takakuni Maki, Masafumi Ihara, Youshi Fujita, Takuo Nambu, Hiroshi Harada, Hidefumi Ito, Kazuwa Nakao, Hidekazu Tomimoto, Ryosuke Takahashi Angiogenic roles of adrenomedullin through vascular endothelial growth factor induction Angiogenic roles of adrenomedullin through vascular endothelial growth factor induction Angiogenic roles of adrenomedullin through vascular endothelial growth factor induction NEUROREPORT, 22, 9, 442-447 NEUROREPORT, 22, 9, 442-447 NEUROREPORT, 22, 9, 442-447 2011/06 Refereed English Research paper(scientific journal) Disclose to all
Takakuni Maki, Masafumi Ihara, Youshi Fujita, Takuo Nambu, Hiroshi Harada, Hidefumi Ito, Kazuwa Nakao, Hidekazu Tomimoto, Ryosuke Takahashi Takakuni Maki, Masafumi Ihara, Youshi Fujita, Takuo Nambu, Hiroshi Harada, Hidefumi Ito, Kazuwa Nakao, Hidekazu Tomimoto, Ryosuke Takahashi Takakuni Maki, Masafumi Ihara, Youshi Fujita, Takuo Nambu, Hiroshi Harada, Hidefumi Ito, Kazuwa Nakao, Hidekazu Tomimoto, Ryosuke Takahashi Angiogenic roles of adrenomedullin through vascular endothelial growth factor induction Angiogenic roles of adrenomedullin through vascular endothelial growth factor induction Angiogenic roles of adrenomedullin through vascular endothelial growth factor induction NEUROREPORT, 22, 9, 442-447 NEUROREPORT, 22, 9, 442-447 NEUROREPORT, 22, 9, 442-447 2011/06 Refereed English Research paper(scientific journal) Disclose to all
Takakuni Maki, Masafumi Ihara, Youshi Fujita, Takuo Nambu, Kazutoshi Miyashita, Mahito Yamada, Kazuo Washida, Keiko Nishio, Hidefumi Ito, Hiroshi Harada, Hideki Yokoi, Hiroshi Arai, Hiroshi Itoh, Kazuwa Nakao, Ryosuke Takahashi, Hidekazu Tomimoto Takakuni Maki, Masafumi Ihara, Youshi Fujita, Takuo Nambu, Kazutoshi Miyashita, Mahito Yamada, Kazuo Washida, Keiko Nishio, Hidefumi Ito, Hiroshi Harada, Hideki Yokoi, Hiroshi Arai, Hiroshi Itoh, Kazuwa Nakao, Ryosuke Takahashi, Hidekazu Tomimoto Takakuni Maki, Masafumi Ihara, Youshi Fujita, Takuo Nambu, Kazutoshi Miyashita, Mahito Yamada, Kazuo Washida, Keiko Nishio, Hidefumi Ito, Hiroshi Harada, Hideki Yokoi, Hiroshi Arai, Hiroshi Itoh, Kazuwa Nakao, Ryosuke Takahashi, Hidekazu Tomimoto Angiogenic and Vasoprotective Effects of Adrenomedullin on Prevention of Cognitive Decline After Chronic Cerebral Hypoperfusion in Mice Angiogenic and Vasoprotective Effects of Adrenomedullin on Prevention of Cognitive Decline After Chronic Cerebral Hypoperfusion in Mice Angiogenic and Vasoprotective Effects of Adrenomedullin on Prevention of Cognitive Decline After Chronic Cerebral Hypoperfusion in Mice STROKE, 42, 4, 1122-1128 STROKE, 42, 4, 1122-1128 STROKE, 42, 4, 1122-1128 2011/04 Refereed English Research paper(scientific journal) Disclose to all
Harada H, Itasaka S, Shibuya K, Masunaga S, Hiraoka M Harada H, Itasaka S, Shibuya K, Masunaga S, Hiraoka M Harada H, Itasaka S, Shibuya K, Masunaga S, Hiraoka M HIF-1-Dependent Cellular Dynamics behind Tumor Recurrence after Radiation Therapy HIF-1-Dependent Cellular Dynamics behind Tumor Recurrence after Radiation Therapy HIF-1-Dependent Cellular Dynamics behind Tumor Recurrence after Radiation Therapy Progress Report 2010, The Research Reactor Institute, Kyoto University, 144 Progress Report 2010, The Research Reactor Institute, Kyoto University, 144 Progress Report 2010, The Research Reactor Institute, Kyoto University, 144 2011 English Disclose to all
Mehmet Zeynel Cilek, Satoshi Hirohata, Omer Faruk Hatipoglu, Hiroko Ogawa, Toru Miyoshi, Junko Inagaki, Takashi Ohtsuki, Hiroshi Harada, Shigeshi Kamikawa, Shozo Kusachi, Yoshifumi Ninomiya Mehmet Zeynel Cilek, Satoshi Hirohata, Omer Faruk Hatipoglu, Hiroko Ogawa, Toru Miyoshi, Junko Inagaki, Takashi Ohtsuki, Hiroshi Harada, Shigeshi Kamikawa, Shozo Kusachi, Yoshifumi Ninomiya Mehmet Zeynel Cilek, Satoshi Hirohata, Omer Faruk Hatipoglu, Hiroko Ogawa, Toru Miyoshi, Junko Inagaki, Takashi Ohtsuki, Hiroshi Harada, Shigeshi Kamikawa, Shozo Kusachi, Yoshifumi Ninomiya AHR, a novel acute hypoxia-response sequence, drives reporter gene expression under hypoxia in vitro and in vivo. AHR, a novel acute hypoxia-response sequence, drives reporter gene expression under hypoxia in vitro and in vivo. AHR, a novel acute hypoxia-response sequence, drives reporter gene expression under hypoxia in vitro and in vivo. Cell biology international, 35, 1, 1-8 Cell biology international, 35, 1, 1-8 Cell biology international, 35, 1, 1-8 2011/01 Refereed English Disclose to all
Koji Miki, Akinori Kimura, Kazuaki Oride, Yoshiaki Kuramochi, Hideki Matsuoka, Hiroshi Harada, Masahiro Hiraoka, Kouichi Ohe Koji Miki, Akinori Kimura, Kazuaki Oride, Yoshiaki Kuramochi, Hideki Matsuoka, Hiroshi Harada, Masahiro Hiraoka, Kouichi Ohe Koji Miki, Akinori Kimura, Kazuaki Oride, Yoshiaki Kuramochi, Hideki Matsuoka, Hiroshi Harada, Masahiro Hiraoka, Kouichi Ohe High-Contrast Fluorescence Imaging of Tumors In Vivo Using Nanoparticles of Amphiphilic Brush-Like Copolymers Produced by ROMP High-Contrast Fluorescence Imaging of Tumors In Vivo Using Nanoparticles of Amphiphilic Brush-Like Copolymers Produced by ROMP High-Contrast Fluorescence Imaging of Tumors In Vivo Using Nanoparticles of Amphiphilic Brush-Like Copolymers Produced by ROMP ANGEWANDTE CHEMIE-INTERNATIONAL EDITION, 50, 29, 6567-6570 ANGEWANDTE CHEMIE-INTERNATIONAL EDITION, 50, 29, 6567-6570 ANGEWANDTE CHEMIE-INTERNATIONAL EDITION, 50, 29, 6567-6570 2011 Refereed English Research paper(scientific journal) Disclose to all
Harada H Harada H Harada H Gene Therapy Strategy for Tumor Hypoxia. Gene Therapy Strategy for Tumor Hypoxia. Gene Therapy Strategy for Tumor Hypoxia. Targets in Gene Therapy. 11: 185-200. 2011. Targets in Gene Therapy. 11: 185-200. 2011. Targets in Gene Therapy. 11: 185-200. 2011. 2011 Refereed English Disclose to all
Koji Miki, Akinori Kimura, Kazuaki Oride, Yoshiaki Kuramochi, Hideki Matsuoka, Hiroshi Harada, Masahiro Hiraoka, Kouichi Ohe Koji Miki, Akinori Kimura, Kazuaki Oride, Yoshiaki Kuramochi, Hideki Matsuoka, Hiroshi Harada, Masahiro Hiraoka, Kouichi Ohe Koji Miki, Akinori Kimura, Kazuaki Oride, Yoshiaki Kuramochi, Hideki Matsuoka, Hiroshi Harada, Masahiro Hiraoka, Kouichi Ohe High-Contrast Fluorescence Imaging of Tumors In Vivo Using Nanoparticles of Amphiphilic Brush-Like Copolymers Produced by ROMP High-Contrast Fluorescence Imaging of Tumors In Vivo Using Nanoparticles of Amphiphilic Brush-Like Copolymers Produced by ROMP High-Contrast Fluorescence Imaging of Tumors In Vivo Using Nanoparticles of Amphiphilic Brush-Like Copolymers Produced by ROMP ANGEWANDTE CHEMIE-INTERNATIONAL EDITION, 50, 29, 6567-6570 ANGEWANDTE CHEMIE-INTERNATIONAL EDITION, 50, 29, 6567-6570 ANGEWANDTE CHEMIE-INTERNATIONAL EDITION, 50, 29, 6567-6570 2011 Refereed English Research paper(scientific journal) Disclose to all
原田 浩, 平岡 眞寛 原田 浩, 平岡 眞寛 がんに対する高精度放射線治療法の確立を見据えた低酸素イメージングの方向性 (特集 PET/CTと放射線治療計画) がんに対する高精度放射線治療法の確立を見据えた低酸素イメージングの方向性 (特集 PET/CTと放射線治療計画) PET journal, 15, 41-43 PET journal, 15, 41-43 , 15, 41-43 2011 Japanese Disclose to all
C.J. Yeom, L. Zeng, Y. Zhu, M. Hiraoka, H. Harada C.J. Yeom, L. Zeng, Y. Zhu, M. Hiraoka, H. Harada C.J. Yeom, L. Zeng, Y. Zhu, M. Hiraoka, H. Harada Strategies to assess hypoxic/HIF-1-active cancer cells for the development of innovative radiation therapy Strategies to assess hypoxic/HIF-1-active cancer cells for the development of innovative radiation therapy Strategies to assess hypoxic/HIF-1-active cancer cells for the development of innovative radiation therapy Cancers, 3, 3, 3610-3631 Cancers, 3, 3, 3610-3631 Cancers, 3, 3, 3610-3631 2011 Refereed English Disclose to all
原田 浩, 板坂 聡, 吉村 通央, 平岡 真寛 原田 浩, 板坂 聡, 吉村 通央, 平岡 真寛 放射線治療後のがん局所再発における低酸素がん細胞の動態解析 放射線治療後のがん局所再発における低酸素がん細胞の動態解析 日本放射線影響学会大会講演要旨集, 53回, 110-110 日本放射線影響学会大会講演要旨集, 53回, 110-110 , 53回, 110-110 2010/10 Refereed Japanese Disclose to all
Hiroshi Harada, Masahiro Hiraoka Hiroshi Harada, Masahiro Hiraoka Hiroshi Harada, Masahiro Hiraoka Hypoxia-Inducible Factor 1 in Tumor Radioresistance Hypoxia-Inducible Factor 1 in Tumor Radioresistance Hypoxia-Inducible Factor 1 in Tumor Radioresistance CURRENT SIGNAL TRANSDUCTION THERAPY, 5, 3, 188-196 CURRENT SIGNAL TRANSDUCTION THERAPY, 5, 3, 188-196 CURRENT SIGNAL TRANSDUCTION THERAPY, 5, 3, 188-196 2010/09 Refereed English Disclose to all
Dalip Kumar, N. Maruthi Kumar, Kanako Akamatsu, Eriko Kusaka, Hiroshi Harada, Takeo Ito Dalip Kumar, N. Maruthi Kumar, Kanako Akamatsu, Eriko Kusaka, Hiroshi Harada, Takeo Ito Dalip Kumar, N. Maruthi Kumar, Kanako Akamatsu, Eriko Kusaka, Hiroshi Harada, Takeo Ito Synthesis and biological evaluation of indolyl chalcones as antitumor agents Synthesis and biological evaluation of indolyl chalcones as antitumor agents Synthesis and biological evaluation of indolyl chalcones as antitumor agents BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 20, 13, 3916-3919 BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 20, 13, 3916-3919 BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 20, 13, 3916-3919 2010/07 Refereed English Research paper(scientific journal) Disclose to all
Hirokazu Komatsu, Hiroshi Harada, Kazuhito Tanabe, Masahiro Hiraoka, Sei-ichi Nishimoto Hirokazu Komatsu, Hiroshi Harada, Kazuhito Tanabe, Masahiro Hiraoka, Sei-ichi Nishimoto Hirokazu Komatsu, Hiroshi Harada, Kazuhito Tanabe, Masahiro Hiraoka, Sei-ichi Nishimoto Indolequinone-rhodol conjugate as a fluorescent probe for hypoxic cells: enzymatic activation and fluorescence properties Indolequinone-rhodol conjugate as a fluorescent probe for hypoxic cells: enzymatic activation and fluorescence properties Indolequinone-rhodol conjugate as a fluorescent probe for hypoxic cells: enzymatic activation and fluorescence properties MEDCHEMCOMM, 1, 1, 50-53 MEDCHEMCOMM, 1, 1, 50-53 MEDCHEMCOMM, 1, 1, 50-53 2010/07 Refereed English Research paper(scientific journal) Disclose to all
Tao Zhao, Hiroshi Harada, Yuji Teramura, Shotaro Tanaka, Satoshi Itasaka, Akiyo Morinibu, Kazumi Shinomiya, Yuxi Zhu, Hirofumi Hanaoka, Hiroo Iwata, Hideo Saji, Masahiro Hiraoka Tao Zhao, Hiroshi Harada, Yuji Teramura, Shotaro Tanaka, Satoshi Itasaka, Akiyo Morinibu, Kazumi Shinomiya, Yuxi Zhu, Hirofumi Hanaoka, Hiroo Iwata, Hideo Saji, Masahiro Hiraoka Tao Zhao, Hiroshi Harada, Yuji Teramura, Shotaro Tanaka, Satoshi Itasaka, Akiyo Morinibu, Kazumi Shinomiya, Yuxi Zhu, Hirofumi Hanaoka, Hiroo Iwata, Hideo Saji, Masahiro Hiraoka A novel strategy to tag matrix metalloproteinases-positive cells for in vivo imaging of invasive and metastatic activity of tumor cells A novel strategy to tag matrix metalloproteinases-positive cells for in vivo imaging of invasive and metastatic activity of tumor cells A novel strategy to tag matrix metalloproteinases-positive cells for in vivo imaging of invasive and metastatic activity of tumor cells JOURNAL OF CONTROLLED RELEASE, 144, 1, 109-114 JOURNAL OF CONTROLLED RELEASE, 144, 1, 109-114 JOURNAL OF CONTROLLED RELEASE, 144, 1, 109-114 2010/05 Refereed English Research paper(scientific journal) Disclose to all
Koji Miki, Kazuaki Oride, Satoru Inoue, Yoshiaki Kuramochi, Rati R. Nayak, Hideki Matsuoka, Hiroshi Harada, Masahiro Hiraoka, Kouichi Ohe Koji Miki, Kazuaki Oride, Satoru Inoue, Yoshiaki Kuramochi, Rati R. Nayak, Hideki Matsuoka, Hiroshi Harada, Masahiro Hiraoka, Kouichi Ohe Koji Miki, Kazuaki Oride, Satoru Inoue, Yoshiaki Kuramochi, Rati R. Nayak, Hideki Matsuoka, Hiroshi Harada, Masahiro Hiraoka, Kouichi Ohe Ring-opening metathesis polymerization-based synthesis of polymeric nanoparticles for enhanced tumor imaging in vivo: Synergistic effect of folate-receptor targeting and PEGylation Ring-opening metathesis polymerization-based synthesis of polymeric nanoparticles for enhanced tumor imaging in vivo: Synergistic effect of folate-receptor targeting and PEGylation Ring-opening metathesis polymerization-based synthesis of polymeric nanoparticles for enhanced tumor imaging in vivo: Synergistic effect of folate-receptor targeting and PEGylation BIOMATERIALS, 31, 5, 934-942 BIOMATERIALS, 31, 5, 934-942 BIOMATERIALS, 31, 5, 934-942 2010/02 Refereed English Research paper(scientific journal) Disclose to all
Harada H, Itasaka S, Shibuya K, Masunaga S, Hiraoka M Harada H, Itasaka S, Shibuya K, Masunaga S, Hiraoka M Harada H, Itasaka S, Shibuya K, Masunaga S, Hiraoka M Optical Imaging of Intratumor HIF-1 Activity to Optimize Treatment Regimen for the Combination of a HIF-1 Inhibitor with Radiation Therapy. Optical Imaging of Intratumor HIF-1 Activity to Optimize Treatment Regimen for the Combination of a HIF-1 Inhibitor with Radiation Therapy. Optical Imaging of Intratumor HIF-1 Activity to Optimize Treatment Regimen for the Combination of a HIF-1 Inhibitor with Radiation Therapy. KURRRI Progress Report 2009, 172-0 KURRRI Progress Report 2009, 172-0 KURRRI Progress Report 2009, 172-0 2010 English Disclose to all
原田 浩, 平岡 眞寛 原田 浩, 平岡 眞寛 癌の放射線抵抗性機構の解明と放射線治療への展開--HIF-1活性のイメージング研究に基づく提言 (特集 第39回放射線による制癌シンポジウム--基礎と臨床との対話 21世紀の放射線による先端医療と研究のさらなる発展を目指して) -- (追い風の臨床放射線,向かい風の基礎放射線--クリーンベンチの風はベッドサイドに届くのか?--トランスレーショナル研究) 癌の放射線抵抗性機構の解明と放射線治療への展開--HIF-1活性のイメージング研究に基づく提言 (特集 第39回放射線による制癌シンポジウム--基礎と臨床との対話 21世紀の放射線による先端医療と研究のさらなる発展を目指して) -- (追い風の臨床放射線,向かい風の基礎放射線--クリーンベンチの風はベッドサイドに届くのか?--トランスレーショナル研究) 癌の臨床, 55, 12, 847-853 癌の臨床, 55, 12, 847-853 , 55, 12, 847-853 2009/12 Japanese Disclose to all
Kazuhito Tanabe, Hiroshi Harada, Michiko Narazaki, Kazuo Tanaka, Kenichi Inafuku, Hirokazu Komatsu, Takeo Ito, Hisatsugu Yamada, Yoshiki Chujo, Tetsuya Matsuda, Masahiro Hiraoka, Sei-ichi Nishimoto Kazuhito Tanabe, Hiroshi Harada, Michiko Narazaki, Kazuo Tanaka, Kenichi Inafuku, Hirokazu Komatsu, Takeo Ito, Hisatsugu Yamada, Yoshiki Chujo, Tetsuya Matsuda, Masahiro Hiraoka, Sei-ichi Nishimoto Kazuhito Tanabe, Hiroshi Harada, Michiko Narazaki, Kazuo Tanaka, Kenichi Inafuku, Hirokazu Komatsu, Takeo Ito, Hisatsugu Yamada, Yoshiki Chujo, Tetsuya Matsuda, Masahiro Hiraoka, Sei-ichi Nishimoto Monitoring of Biological One-Electron Reduction by F-19 NMR Using Hypoxia Selective Activation of an F-19-Labeled Indolequinone Derivative Monitoring of Biological One-Electron Reduction by F-19 NMR Using Hypoxia Selective Activation of an F-19-Labeled Indolequinone Derivative Monitoring of Biological One-Electron Reduction by F-19 NMR Using Hypoxia Selective Activation of an F-19-Labeled Indolequinone Derivative JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 131, 44, 15982-+ JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 131, 44, 15982-+ JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 131, 44, 15982-+ 2009/11 Refereed English Research paper(scientific journal) Disclose to all
Guangfei Ou, Satoshi Itasaka, Lihua Zeng, Keiko Shibuya, Junlin Yi, Hiroshi Harada, Masahiro Hiraoka Guangfei Ou, Satoshi Itasaka, Lihua Zeng, Keiko Shibuya, Junlin Yi, Hiroshi Harada, Masahiro Hiraoka Guangfei Ou, Satoshi Itasaka, Lihua Zeng, Keiko Shibuya, Junlin Yi, Hiroshi Harada, Masahiro Hiraoka USEFULNESS OF HIF-1 IMAGING FOR DETERMINING OPTIMAL TIMING OF COMBINING BEVACIZUMAB AND RADIOTHERAPY USEFULNESS OF HIF-1 IMAGING FOR DETERMINING OPTIMAL TIMING OF COMBINING BEVACIZUMAB AND RADIOTHERAPY USEFULNESS OF HIF-1 IMAGING FOR DETERMINING OPTIMAL TIMING OF COMBINING BEVACIZUMAB AND RADIOTHERAPY INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS, 75, 2, 463-467 INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS, 75, 2, 463-467 INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS, 75, 2, 463-467 2009/10 Refereed English Research paper(scientific journal) Disclose to all
Takuhiko Wakamatsu, Tomoharu Tanaka, Seiko Oda, Kenichiro Nishi, Hiroshi Harada, Hiroki Daijo, Satoshi Takabuchi, Shinichi Kai, Kazuhiko Fukuda, Kiichi Hirota Takuhiko Wakamatsu, Tomoharu Tanaka, Seiko Oda, Kenichiro Nishi, Hiroshi Harada, Hiroki Daijo, Satoshi Takabuchi, Shinichi Kai, Kazuhiko Fukuda, Kiichi Hirota Takuhiko Wakamatsu, Tomoharu Tanaka, Seiko Oda, Kenichiro Nishi, Hiroshi Harada, Hiroki Daijo, Satoshi Takabuchi, Shinichi Kai, Kazuhiko Fukuda, Kiichi Hirota The intravenous anesthetics barbiturates inhibit hypoxia-inducible factor 1 activation The intravenous anesthetics barbiturates inhibit hypoxia-inducible factor 1 activation The intravenous anesthetics barbiturates inhibit hypoxia-inducible factor 1 activation EUROPEAN JOURNAL OF PHARMACOLOGY, 617, 1-3, 17-22 EUROPEAN JOURNAL OF PHARMACOLOGY, 617, 1-3, 17-22 EUROPEAN JOURNAL OF PHARMACOLOGY, 617, 1-3, 17-22 2009/09 Refereed English Research paper(scientific journal) Disclose to all
原田浩 原田浩 2nd Asian Congress of Radiation Research(アジア放射線研究会議)に参加して 2nd Asian Congress of Radiation Research(アジア放射線研究会議)に参加して 放射線生物研究, 44, 3, 360-362 放射線生物研究, 44, 3, 360-362 , 44, 3, 360-362 2009/09 Japanese Disclose to all
Shinae Kizaka-Kondoh, Shotaro Tanaka, Hiroshi Harada, Masahiro Hiraoka Shinae Kizaka-Kondoh, Shotaro Tanaka, Hiroshi Harada, Masahiro Hiraoka Shinae Kizaka-Kondoh, Shotaro Tanaka, Hiroshi Harada, Masahiro Hiraoka The HIF-1-active microenvironment: An environmental target for cancer therapy The HIF-1-active microenvironment: An environmental target for cancer therapy The HIF-1-active microenvironment: An environmental target for cancer therapy ADVANCED DRUG DELIVERY REVIEWS, 61, 7-8, 623-632 ADVANCED DRUG DELIVERY REVIEWS, 61, 7-8, 623-632 ADVANCED DRUG DELIVERY REVIEWS, 61, 7-8, 623-632 2009/07 Refereed English Disclose to all
H. Harada, S. Itasaka, Y. Zhu, L. Zeng, X. Xie, A. Morinibu, K. Shinomiya, M. Hiraoka H. Harada, S. Itasaka, Y. Zhu, L. Zeng, X. Xie, A. Morinibu, K. Shinomiya, M. Hiraoka H. Harada, S. Itasaka, Y. Zhu, L. Zeng, X. Xie, A. Morinibu, K. Shinomiya, M. Hiraoka Treatment regimen determines whether an HIF-1 inhibitor enhances or inhibits the effect of radiation therapy Treatment regimen determines whether an HIF-1 inhibitor enhances or inhibits the effect of radiation therapy Treatment regimen determines whether an HIF-1 inhibitor enhances or inhibits the effect of radiation therapy BRITISH JOURNAL OF CANCER, 100, 5, 747-757 BRITISH JOURNAL OF CANCER, 100, 5, 747-757 BRITISH JOURNAL OF CANCER, 100, 5, 747-757 2009/03 Refereed English Research paper(scientific journal) Disclose to all
原田浩, 平岡真寛 原田浩, 平岡真寛 Hypoxia-inducible Factor-1(HIF-1)による放射線治療後の腫瘍増殖亢進機構 Hypoxia-inducible Factor-1(HIF-1)による放射線治療後の腫瘍増殖亢進機構 放射線生物研究, 44, 1, 60-69 放射線生物研究, 44, 1, 60-69 , 44, 1, 60-69 2009/03 Japanese Disclose to all
Koji Miki, Yoshiaki Kuramochi, Kazuaki Oride, Satoru Inoue, Hiroshi Harada, Masahiro Hiraoka, Kouichi Ohe Koji Miki, Yoshiaki Kuramochi, Kazuaki Oride, Satoru Inoue, Hiroshi Harada, Masahiro Hiraoka, Kouichi Ohe Koji Miki, Yoshiaki Kuramochi, Kazuaki Oride, Satoru Inoue, Hiroshi Harada, Masahiro Hiraoka, Kouichi Ohe Ring-Opening Metathesis Polymerization-Based Synthesis of ICG-Containing Amphiphilic Triblock Copolymers for in Vivo Tumor Imaging Ring-Opening Metathesis Polymerization-Based Synthesis of ICG-Containing Amphiphilic Triblock Copolymers for in Vivo Tumor Imaging Ring-Opening Metathesis Polymerization-Based Synthesis of ICG-Containing Amphiphilic Triblock Copolymers for in Vivo Tumor Imaging BIOCONJUGATE CHEMISTRY, 20, 3, 511-517 BIOCONJUGATE CHEMISTRY, 20, 3, 511-517 BIOCONJUGATE CHEMISTRY, 20, 3, 511-517 2009/03 Refereed English Research paper(scientific journal) Disclose to all
Hiroshi Harada, Satoshi Itasaka, Shinae Kizaka-Kondoh, Keiko Shibuya, Akiyo Morinibu, Kazumi Shinomiya, Masahiro Hiraoka H. Harada, S. Itasaka, S. Kizaka-Kondoh, K. Shibuya, A. Morinibu, K. Shinomiya, M. Hiraoka Hiroshi Harada, Satoshi Itasaka, Shinae Kizaka-Kondoh, Keiko Shibuya, Akiyo Morinibu, Kazumi Shinomiya, Masahiro Hiraoka The Akt/mTOR Pathway Assures the Synthesis of HIF-1 alpha Protein in a Glucose- and Reoxygenation-dependent Manner in Irradiated Tumors The Akt/mTOR pathway assures the synthesis of HIF-1α protein in a glucose- and reoxygenation-dependent manner in irradiated tumors The Akt/mTOR Pathway Assures the Synthesis of HIF-1 alpha Protein in a Glucose- and Reoxygenation-dependent Manner in Irradiated Tumors JOURNAL OF BIOLOGICAL CHEMISTRY, 284, 8, 5332-5342 Journal of Biological Chemistry, 284, 8, 5332-5342 JOURNAL OF BIOLOGICAL CHEMISTRY, 284, 8, 5332-5342 2009/02 Refereed English Research paper(scientific journal) Disclose to all
原田浩, 平岡真寛 原田浩, 平岡真寛 低酸素がん細胞の光学イメージング. 低酸素がん細胞の光学イメージング. からだと酸素の事典. からだと酸素の事典. 2009 Japanese Disclose to all
Ou G, Itasaka S, Zeng L, Shibuya K, Yi J, Harada H, Hiraoka M Ou G, Itasaka S, Zeng L, Shibuya K, Yi J, Harada H, Hiraoka M Ou G, Itasaka S, Zeng L, Shibuya K, Yi J, Harada H, Hiraoka M HIF imaging is useful to determine the timing of combining Bevacizumab with radiation. HIF imaging is useful to determine the timing of combining Bevacizumab with radiation. HIF imaging is useful to determine the timing of combining Bevacizumab with radiation. Int J Radiat Oncol Biol Phys. 75:463-467. 2009. Int J Radiat Oncol Biol Phys. 75:463-467. 2009. Int J Radiat Oncol Biol Phys. 75:463-467. 2009. 2009 Refereed English Disclose to all
Nao Hirata, Yusuke Fujisawa, Kazuhito Tanabe, Hiroshi Harada, Masahiro Hiraoka, Sei-ichi Nishimoto Nao Hirata, Yusuke Fujisawa, Kazuhito Tanabe, Hiroshi Harada, Masahiro Hiraoka, Sei-ichi Nishimoto Nao Hirata, Yusuke Fujisawa, Kazuhito Tanabe, Hiroshi Harada, Masahiro Hiraoka, Sei-ichi Nishimoto Radiolytic activation of a cytarabine prodrug possessing a 2-oxoalkyl group: one-electron reduction and cytotoxicity characteristics Radiolytic activation of a cytarabine prodrug possessing a 2-oxoalkyl group: one-electron reduction and cytotoxicity characteristics Radiolytic activation of a cytarabine prodrug possessing a 2-oxoalkyl group: one-electron reduction and cytotoxicity characteristics ORGANIC & BIOMOLECULAR CHEMISTRY, 7, 4, 651-654 ORGANIC & BIOMOLECULAR CHEMISTRY, 7, 4, 651-654 ORGANIC & BIOMOLECULAR CHEMISTRY, 7, 4, 651-654 2009 Refereed English Research paper(scientific journal) Disclose to all
TANABE Kazuhito, KOMATSU Hirokazu, HARADA Hiroshi, HIRAOKA Masahiro, NISHIMOTO Sei‐ichi TANABE Kazuhito, KOMATSU Hirokazu, HARADA Hiroshi, HIRAOKA Masahiro, NISHIMOTO Sei‐ichi TANABE Kazuhito, KOMATSU Hirokazu, HARADA Hiroshi, HIRAOKA Masahiro, NISHIMOTO Sei‐ichi Monitoring of Hypoxia-selective Enzymatic Reduction of Indolequinone derivative by 19F-NMR Monitoring of Hypoxia-selective Enzymatic Reduction of Indolequinone derivative by 19F-NMR Monitoring of Hypoxia-selective Enzymatic Reduction of Indolequinone derivative by 19F-NMR Photomedicine Photobiol, 31, 31-32 Photomedicine Photobiol, 31, 31-32 Photomedicine Photobiol, 31, 31-32 2009 Refereed English Disclose to all
Lihua Zeng, Guangfei Ou, Satoshi Itasaka, Hiroshi Harada, Xuejun Xie, Keiko Shibuya, Shinae Kizaka-Kondoh, Akiyo Morinibu, Kazumi Shinomiya, Masahiro Hiraoka Lihua Zeng, Guangfei Ou, Satoshi Itasaka, Hiroshi Harada, Xuejun Xie, Keiko Shibuya, Shinae Kizaka-Kondoh, Akiyo Morinibu, Kazumi Shinomiya, Masahiro Hiraoka Lihua Zeng, Guangfei Ou, Satoshi Itasaka, Hiroshi Harada, Xuejun Xie, Keiko Shibuya, Shinae Kizaka-Kondoh, Akiyo Morinibu, Kazumi Shinomiya, Masahiro Hiraoka TS-1 enhances the effect of radiotherapy by suppressing radiation-induced hypoxia-inducible factor-1 activation and inducing endothelial cell apoptosis TS-1 enhances the effect of radiotherapy by suppressing radiation-induced hypoxia-inducible factor-1 activation and inducing endothelial cell apoptosis TS-1 enhances the effect of radiotherapy by suppressing radiation-induced hypoxia-inducible factor-1 activation and inducing endothelial cell apoptosis CANCER SCIENCE, 99, 11, 2327-2335 CANCER SCIENCE, 99, 11, 2327-2335 CANCER SCIENCE, 99, 11, 2327-2335 2008/11 Refereed English Research paper(scientific journal) Disclose to all
Hiroshi Harada, Xuejun Xie, Satoshi Itasaka, Lihua Zeng, Yuxi Zhu, Akiyo Morinibu, Kazumi Shinomiya, Masahiro Hiraoka Hiroshi Harada, Xuejun Xie, Satoshi Itasaka, Lihua Zeng, Yuxi Zhu, Akiyo Morinibu, Kazumi Shinomiya, Masahiro Hiraoka Hiroshi Harada, Xuejun Xie, Satoshi Itasaka, Lihua Zeng, Yuxi Zhu, Akiyo Morinibu, Kazumi Shinomiya, Masahiro Hiraoka Diameter of tumor blood vessels is a good parameter to estimate HIF-1-active regions in solid tumors Diameter of tumor blood vessels is a good parameter to estimate HIF-1-active regions in solid tumors Diameter of tumor blood vessels is a good parameter to estimate HIF-1-active regions in solid tumors BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 373, 4, 533-538 BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 373, 4, 533-538 BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 373, 4, 533-538 2008/09 Refereed English Research paper(scientific journal) Disclose to all
原田浩, 板坂聡, 平岡真寛 原田浩, 板坂聡, 平岡真寛 分子イメージングによる放射線治療の新展開. 分子イメージングによる放射線治療の新展開. JSMI Report. 1: 5-8. 2008. JSMI Report. 1: 5-8. 2008. 2008 Japanese Disclose to all
板坂聡, 原田浩, 近藤科江, 平岡真寛 板坂聡, 原田浩, 近藤科江, 平岡真寛 新しい治療法評価への分子イメージングの応用・放射線治療の分子イメージング 新しい治療法評価への分子イメージングの応用・放射線治療の分子イメージング 遺伝子医学MOOK. 9:279-283. 2008. 遺伝子医学MOOK. 9:279-283. 2008. 2008 Japanese Disclose to all
原田浩, 平岡真寛 原田浩, 平岡真寛 腫瘍内HIF-1活性の光イメージング –その方法と重要性-. 腫瘍内HIF-1活性の光イメージング –その方法と重要性-. 癌の臨床. 54:97-103. 2008. 癌の臨床. 54:97-103. 2008. 2008 Japanese Disclose to all
Kazuhito Tanabe, Nao Hirata, Hiroshi Harada, Masahiro Hiraoka, Sei-ichi Nishimoto Kazuhito Tanabe, Nao Hirata, Hiroshi Harada, Masahiro Hiraoka, Sei-ichi Nishimoto Kazuhito Tanabe, Nao Hirata, Hiroshi Harada, Masahiro Hiraoka, Sei-ichi Nishimoto Emission under hypoxia: One-electron reduction and fluorescence characteristics of an indolequinone-coumarin conjugate Emission under hypoxia: One-electron reduction and fluorescence characteristics of an indolequinone-coumarin conjugate Emission under hypoxia: One-electron reduction and fluorescence characteristics of an indolequinone-coumarin conjugate CHEMBIOCHEM, 9, 3, 426-432 CHEMBIOCHEM, 9, 3, 426-432 CHEMBIOCHEM, 9, 3, 426-432 2008/01 Refereed English Research paper(scientific journal) Disclose to all
Kazuhito Tanabe, Nao Hirata, Hiroshi Harada, Masahiro Hiraoka, Sei-ichi Nishimoto Kazuhito Tanabe, Nao Hirata, Hiroshi Harada, Masahiro Hiraoka, Sei-ichi Nishimoto Kazuhito Tanabe, Nao Hirata, Hiroshi Harada, Masahiro Hiraoka, Sei-ichi Nishimoto Emission under hypoxia: One-electron reduction and fluorescence characteristics of an indolequinone-coumarin conjugate Emission under hypoxia: One-electron reduction and fluorescence characteristics of an indolequinone-coumarin conjugate Emission under hypoxia: One-electron reduction and fluorescence characteristics of an indolequinone-coumarin conjugate CHEMBIOCHEM, 9, 3, 426-432 CHEMBIOCHEM, 9, 3, 426-432 CHEMBIOCHEM, 9, 3, 426-432 2008/01 Refereed English Research paper(scientific journal) Disclose to all
H. Harada, S. Kizaka-Kondoh, G. Li, S. Itasaka, K. Shibuya, M. Inoue, M. Hiraoka H. Harada, S. Kizaka-Kondoh, G. Li, S. Itasaka, K. Shibuya, M. Inoue, M. Hiraoka H. Harada, S. Kizaka-Kondoh, G. Li, S. Itasaka, K. Shibuya, M. Inoue, M. Hiraoka Significance of HIF-1-active cells in angiogenesis and radioresistance Significance of HIF-1-active cells in angiogenesis and radioresistance Significance of HIF-1-active cells in angiogenesis and radioresistance ONCOGENE, 26, 54, 7508-7516 ONCOGENE, 26, 54, 7508-7516 ONCOGENE, 26, 54, 7508-7516 2007/11 Refereed English Research paper(scientific journal) Disclose to all
Hiroshi Harada, Shinae Kizaka-Kondoh, Satoshi Itasaka, Keiko Shibuya, Akiyo Morinibu, Kazumi Shinomiya, Masahiro Hiraoka Hiroshi Harada, Shinae Kizaka-Kondoh, Satoshi Itasaka, Keiko Shibuya, Akiyo Morinibu, Kazumi Shinomiya, Masahiro Hiraoka Hiroshi Harada, Shinae Kizaka-Kondoh, Satoshi Itasaka, Keiko Shibuya, Akiyo Morinibu, Kazumi Shinomiya, Masahiro Hiraoka The combination of hypoxia-response enhancers and an oxygen-dependent proteolytic motif enables real-time imaging of absolute HIF-1 activity in tumor xenografts The combination of hypoxia-response enhancers and an oxygen-dependent proteolytic motif enables real-time imaging of absolute HIF-1 activity in tumor xenografts The combination of hypoxia-response enhancers and an oxygen-dependent proteolytic motif enables real-time imaging of absolute HIF-1 activity in tumor xenografts BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 360, 4, 791-796 BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 360, 4, 791-796 BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 360, 4, 791-796 2007/09 Refereed English Research paper(scientific journal) Disclose to all
J. Liu, H. Harada, M. Ogura, T. Shibata, M. Hiraoka J. Liu, H. Harada, M. Ogura, T. Shibata, M. Hiraoka J. Liu, H. Harada, M. Ogura, T. Shibata, M. Hiraoka Adenovirus-mediated hypoxia-targeting cytosine deaminase gene therapy enhances radiotherapy in tumour xenografts Adenovirus-mediated hypoxia-targeting cytosine deaminase gene therapy enhances radiotherapy in tumour xenografts Adenovirus-mediated hypoxia-targeting cytosine deaminase gene therapy enhances radiotherapy in tumour xenografts BRITISH JOURNAL OF CANCER, 96, 12, 1871-1878 BRITISH JOURNAL OF CANCER, 96, 12, 1871-1878 BRITISH JOURNAL OF CANCER, 96, 12, 1871-1878 2007/06 Refereed English Research paper(scientific journal) Disclose to all
TANABE Kazuhito, HIRATA Nao, HARADA Hiroshi, HIRAOKA Masahiro, NISHIMOTO Sei‐ichi TANABE Kazuhito, HIRATA Nao, HARADA Hiroshi, HIRAOKA Masahiro, NISHIMOTO Sei‐ichi TANABE Kazuhito, HIRATA Nao, HARADA Hiroshi, HIRAOKA Masahiro, NISHIMOTO Sei‐ichi One-Electron Reduction Characteristics of Indolequinone-Coumarin Conjugate as Hypoxia Imaging Probe One-Electron Reduction Characteristics of Indolequinone-Coumarin Conjugate as Hypoxia Imaging Probe One-Electron Reduction Characteristics of Indolequinone-Coumarin Conjugate as Hypoxia Imaging Probe Photomedicine Photobiol, 29, 23-24 Photomedicine Photobiol, 29, 23-24 Photomedicine Photobiol, 29, 23-24 2007 Refereed English Disclose to all
近藤科江, 原田浩, 田中正太郎, 平岡真寛 近藤科江, 原田浩, 田中正太郎, 平岡真寛 HIF-1を利用した腫瘍内低酸素がん細胞のイメージング・ターゲティング(2) HIF-1を利用した腫瘍内低酸素がん細胞のイメージング・ターゲティング(2) 放射線科学, 49, 12, 436-441 放射線科学, 49, 12, 436-441 , 49, 12, 436-441 2006/12 Japanese Disclose to all
近藤科江, 原田浩, 田中正太郎, 平岡真寛 近藤科江, 原田浩, 田中正太郎, 平岡真寛 HIF-1を利用した腫瘍内低酸素がん細胞のイメージング・ターゲティング(1) HIF-1を利用した腫瘍内低酸素がん細胞のイメージング・ターゲティング(1) 放射線科学, 49, 11, 399-404 放射線科学, 49, 11, 399-404 , 49, 11, 399-404 2006/11 Japanese Disclose to all
Hiroshi Harada, Shinae Kizaka-Kondoh, Masahiro Hiraoka H. Harada, S. Kizaka-Kondoh, M. Hiraoka Hiroshi Harada, Shinae Kizaka-Kondoh, Masahiro Hiraoka Mechanism of hypoxia-specific cytotoxicity of procaspase-3 fused with a VHL-mediated protein destruction motif of HIF-1 alpha containing Pro564 Mechanism of hypoxia-specific cytotoxicity of procaspase-3 fused with a VHL-mediated protein destruction motif of HIF-1α containing Pro564 Mechanism of hypoxia-specific cytotoxicity of procaspase-3 fused with a VHL-mediated protein destruction motif of HIF-1 alpha containing Pro564 FEBS LETTERS, 580, 24, 5718-5722 FEBS Letters, 580, 24, 5718-5722 FEBS LETTERS, 580, 24, 5718-5722 2006/10 Refereed English Research paper(scientific journal) Disclose to all
近藤 科江, 原田 浩, 平岡 真寛 近藤 科江, 原田 浩, 平岡 真寛 『低酸素癌細胞』を標的とした癌のイメージング・ターゲティング (特集2 発光イメージングの突破力) 『低酸素癌細胞』を標的とした癌のイメージング・ターゲティング (特集2 発光イメージングの突破力) バイオテクノロジージャーナル, 6, 2, 234-237 バイオテクノロジージャーナル, 6, 2, 234-237 , 6, 2, 234-237 2006/03 Japanese Disclose to all
近藤科江, 原田浩, 平岡真寛 近藤科江, 原田浩, 平岡真寛 低酸素を標的とした生体イメージング分子プローブの開発 低酸素を標的とした生体イメージング分子プローブの開発 未来医学. 21:32-37. 2006. 未来医学. 21:32-37. 2006. 2006 Japanese Disclose to all
小倉昌和, 柴田徹, 原田浩, 平岡真寛 小倉昌和, 柴田徹, 原田浩, 平岡真寛 腎細胞癌に対する腫瘍特異的遺伝子治療 腎細胞癌に対する腫瘍特異的遺伝子治療 日本臨牀・増刊号・分子腎臓病学. 888:672-677. 2006. 日本臨牀・増刊号・分子腎臓病学. 888:672-677. 2006. 2006 Japanese Disclose to all
H. Harada, S. Kizaka-Kondoh, M. Hiraoka H. Harada, S. Kizaka-Kondoh, M. Hiraoka H. Harada, S. Kizaka-Kondoh, M. Hiraoka Antitumor protein therapy; application of the protein transduction domain to the development of a protein drug for cancer treatment. Antitumor protein therapy; application of the protein transduction domain to the development of a protein drug for cancer treatment. Antitumor protein therapy; application of the protein transduction domain to the development of a protein drug for cancer treatment. Breast cancer (Tokyo, Japan), 13, 1, 16-26 Breast cancer (Tokyo, Japan), 13, 1, 16-26 Breast cancer (Tokyo, Japan), 13, 1, 16-26 2006 Refereed English Disclose to all
M. Ogura, T. Shibata, H. Harada, M. Hiraoka M. Ogura, T. Shibata, H. Harada, M. Hiraoka M. Ogura, T. Shibata, H. Harada, M. Hiraoka Tumor-specific gene therapy strategy for renal cell carcinomas Tumor-specific gene therapy strategy for renal cell carcinomas Tumor-specific gene therapy strategy for renal cell carcinomas Nippon rinsho. Japanese journal of clinical medicine., 64 Suppl 2, 672-675 Nippon rinsho. Japanese journal of clinical medicine., 64 Suppl 2, 672-675 Nippon rinsho. Japanese journal of clinical medicine., 64 Suppl 2, 672-675 2006 Refereed English Disclose to all
Z Zhang, H Harada, K Tanabe, H Hatta, M Hiraoka, S Nishimoto Z Zhang, H Harada, K Tanabe, H Hatta, M Hiraoka, S Nishimoto Z Zhang, H Harada, K Tanabe, H Hatta, M Hiraoka, S Nishimoto Aminopeptidase N/CD13 targeting fluorescent probes: Synthesis and application to tumor cell imaging Aminopeptidase N/CD13 targeting fluorescent probes: Synthesis and application to tumor cell imaging Aminopeptidase N/CD13 targeting fluorescent probes: Synthesis and application to tumor cell imaging PEPTIDES, 26, 11, 2182-2187 PEPTIDES, 26, 11, 2182-2187 PEPTIDES, 26, 11, 2182-2187 2005/11 Refereed English Research paper(scientific journal) Disclose to all
Hiroshi Harada, Shinae Kizaka-Kondoh, Masahiro Hiraoka Hiroshi Harada, Shinae Kizaka-Kondoh, Masahiro Hiraoka Hiroshi Harada, Shinae Kizaka-Kondoh, Masahiro Hiraoka Optical Imaging of Tumor Hypoxia and Evaluation of Efficacy of a Hypoxia-Targeting Drug in Living Animals Optical Imaging of Tumor Hypoxia and Evaluation of Efficacy of a Hypoxia-Targeting Drug in Living Animals Optical Imaging of Tumor Hypoxia and Evaluation of Efficacy of a Hypoxia-Targeting Drug in Living Animals MOLECULAR IMAGING, 4, 3, 182-193 MOLECULAR IMAGING, 4, 3, 182-193 MOLECULAR IMAGING, 4, 3, 182-193 2005/07 Refereed English Research paper(scientific journal) Disclose to all
M Ogura, T Shibata, JL Yi, JY Liu, RJ Qu, H Harada, M Hiraoka M Ogura, T Shibata, JL Yi, JY Liu, RJ Qu, H Harada, M Hiraoka M Ogura, T Shibata, JL Yi, JY Liu, RJ Qu, H Harada, M Hiraoka A tumor-specific gene therapy strategy targeting dysregulation of the VHL/HIF pathway in renal cell carcinomas A tumor-specific gene therapy strategy targeting dysregulation of the VHL/HIF pathway in renal cell carcinomas A tumor-specific gene therapy strategy targeting dysregulation of the VHL/HIF pathway in renal cell carcinomas CANCER SCIENCE, 96, 5, 288-294 CANCER SCIENCE, 96, 5, 288-294 CANCER SCIENCE, 96, 5, 288-294 2005/05 Refereed English Research paper(scientific journal) Disclose to all
JY Liu, RJ Qu, M Ogura, T Shibata, H Harada, M Hiraoka JY Liu, RJ Qu, M Ogura, T Shibata, H Harada, M Hiraoka JY Liu, RJ Qu, M Ogura, T Shibata, H Harada, M Hiraoka Real-time imaging of hypoxia-inducible factor-1 activity in tumor xenografts Real-time imaging of hypoxia-inducible factor-1 activity in tumor xenografts Real-time imaging of hypoxia-inducible factor-1 activity in tumor xenografts JOURNAL OF RADIATION RESEARCH, 46, 1, 93-102 JOURNAL OF RADIATION RESEARCH, 46, 1, 93-102 JOURNAL OF RADIATION RESEARCH, 46, 1, 93-102 2005/03 Refereed English Research paper(scientific journal) Disclose to all
近藤科江, 原田浩, 平岡真寛 近藤科江, 原田浩, 平岡真寛 革新的診断・治療へのアプローチ -膜透過性・標的特異性を有する融合タンパク質を用いたイメージング・ターゲティング- 革新的診断・治療へのアプローチ -膜透過性・標的特異性を有する融合タンパク質を用いたイメージング・ターゲティング- Bio Clinica. 20: 53-58. 2005. Bio Clinica. 20: 53-58. 2005. 2005 Japanese Disclose to all
近藤 科江, 平岡 真寛, 原田 浩 近藤 科江, 平岡 真寛, 原田 浩 基礎 癌治療におけるHIF-1とTumor Hypoxia 基礎 癌治療におけるHIF-1とTumor Hypoxia Cancer frontier, 7, 1, 77-86 Cancer frontier, 7, 1, 77-86 , 7, 1, 77-86 2005 Japanese Disclose to all
S Kizaka-Kondoh, M Inoue, H Harada, M Hiraoka S Kizaka-Kondoh, M Inoue, H Harada, M Hiraoka S Kizaka-Kondoh, M Inoue, H Harada, M Hiraoka Tumor hypoxia: A target for selective cancer therapy Tumor hypoxia: A target for selective cancer therapy Tumor hypoxia: A target for selective cancer therapy CANCER SCIENCE, 94, 12, 1021-1028 CANCER SCIENCE, 94, 12, 1021-1028 CANCER SCIENCE, 94, 12, 1021-1028 2003/12 Refereed English Disclose to all
H Harada, M Hiraoka, S Kizaka-Kondoh H Harada, M Hiraoka, S Kizaka-Kondoh H Harada, M Hiraoka, S Kizaka-Kondoh Antitumor effect of TAT-oxygen-dependent degradation-caspase-3 fusion protein specifically stabilized and activated in hypoxic tumor cells Antitumor effect of TAT-oxygen-dependent degradation-caspase-3 fusion protein specifically stabilized and activated in hypoxic tumor cells Antitumor effect of TAT-oxygen-dependent degradation-caspase-3 fusion protein specifically stabilized and activated in hypoxic tumor cells CANCER RESEARCH, 62, 7, 2013-2018 CANCER RESEARCH, 62, 7, 2013-2018 CANCER RESEARCH, 62, 7, 2013-2018 2002/04 Refereed English Research paper(scientific journal) Disclose to all

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Title language:
Misc
Author Author(Japanese) Author(English) Title Title(Japanese) Title(English) Bibliography Bibliography(Japanese) Bibliography(English) Publication date Refereed paper Language Publishing type Disclose
Masataka Tsuda, Kosai Cho, Masato Ooka, Naoto Shimizu, Reiko Watanabe, Akira Yasui, Yuka Nakazawa, Tomoo Ogi, Hiroshi Harada, Keli Agama, Jun Nakamura, Ryuta Asada, Haruna Fujiike, Tetsushi Sakuma, Takashi Yamamoto, Junko Murai, Masahiro Hiraoka, Kaoru Koike, Yves Pommier, Shunichi Takeda, Kouji Hirota Masataka Tsuda, Kosai Cho, Masato Ooka, Naoto Shimizu, Reiko Watanabe, Akira Yasui, Yuka Nakazawa, Tomoo Ogi, Hiroshi Harada, Keli Agama, Jun Nakamura, Ryuta Asada, Haruna Fujiike, Tetsushi Sakuma, Takashi Yamamoto, Junko Murai, Masahiro Hiraoka, Kaoru Koike, Yves Pommier, Shunichi Takeda, Kouji Hirota Masataka Tsuda, Kosai Cho, Masato Ooka, Naoto Shimizu, Reiko Watanabe, Akira Yasui, Yuka Nakazawa, Tomoo Ogi, Hiroshi Harada, Keli Agama, Jun Nakamura, Ryuta Asada, Haruna Fujiike, Tetsushi Sakuma, Takashi Yamamoto, Junko Murai, Masahiro Hiraoka, Kaoru Koike, Yves Pommier, Shunichi Takeda, Kouji Hirota ALC1/CHD1L, a chromatin-remodeling enzyme, is required for efficient base excision repair. ALC1/CHD1L, a chromatin-remodeling enzyme, is required for efficient base excision repair. ALC1/CHD1L, a chromatin-remodeling enzyme, is required for efficient base excision repair. PloS one, 12, 11, e0188320 PloS one, 12, 11, e0188320 PloS one, 12, 11, e0188320 2017 English Disclose to all
子安 翔, 辻 喜久, 原田 浩, 中本 裕士, 野橋 智美, 木村 寛之, 佐野 紘平, 小泉 幸司, 濱路 政嗣, 富樫 かおり 子安 翔, 辻 喜久, 原田 浩, 中本 裕士, 野橋 智美, 木村 寛之, 佐野 紘平, 小泉 幸司, 濱路 政嗣, 富樫 かおり 子安 翔, 辻 喜久, 原田 浩, 中本 裕士, 野橋 智美, 木村 寛之, 佐野 紘平, 小泉 幸司, 濱路 政嗣, 富樫 かおり 造影ダイナミックCTとフッ素18フルオロミソニダゾール陽電子放出断層撮像法を用いた、腫瘍間質の評価および腫瘍低酸素との関連性の評価 造影ダイナミックCTとフッ素18フルオロミソニダゾール陽電子放出断層撮像法を用いた、腫瘍間質の評価および腫瘍低酸素との関連性の評価 造影ダイナミックCTとフッ素18フルオロミソニダゾール陽電子放出断層撮像法を用いた、腫瘍間質の評価および腫瘍低酸素との関連性の評価 JSMI Report, 10, 1, 63-66 JSMI Report, 10, 1, 63-66 JSMI Report, 10, 1, 63-66 2016/12 Japanese Disclose to all
子安 翔, 辻 喜久, 原田 浩, 中本 裕士, 野橋 智美, 木村 寛之, 佐野 紘平, 小泉 幸司, 濱路 政嗣, 富樫 かおり 子安 翔, 辻 喜久, 原田 浩, 中本 裕士, 野橋 智美, 木村 寛之, 佐野 紘平, 小泉 幸司, 濱路 政嗣, 富樫 かおり 子安 翔, 辻 喜久, 原田 浩, 中本 裕士, 野橋 智美, 木村 寛之, 佐野 紘平, 小泉 幸司, 濱路 政嗣, 富樫 かおり 造影ダイナミックCTとフッ素18フルオロミソニダゾール陽電子放出断層撮像法を用いた、腫瘍間質の評価および腫瘍低酸素との関連性の評価 造影ダイナミックCTとフッ素18フルオロミソニダゾール陽電子放出断層撮像法を用いた、腫瘍間質の評価および腫瘍低酸素との関連性の評価 造影ダイナミックCTとフッ素18フルオロミソニダゾール陽電子放出断層撮像法を用いた、腫瘍間質の評価および腫瘍低酸素との関連性の評価 核医学, 53, Suppl., np2-np3 核医学, 53, Suppl., np2-np3 核医学, 53, Suppl., np2-np3 2016/10 Japanese Disclose to all
Gaowa Arong, Tomohisa Horibe, Masayuki Kohno, Hiroshi Harada, Masahiro Hiraoka, Koji Kawakami Gaowa Arong, Tomohisa Horibe, Masayuki Kohno, Hiroshi Harada, Masahiro Hiraoka, Koji Kawakami EGFR-targeted hybrid peptide reduces tumor growth and prolongs survival of mice with metastatic liver cancer EGFR-targeted hybrid peptide reduces tumor growth and prolongs survival of mice with metastatic liver cancer 「第75回日本癌学会学術集会」 2016年10月6日―8日, 横浜 「第75回日本癌学会学術集会」 2016年10月6日―8日, 横浜 2016/10 Disclose to all
Harada H, Masunaga S, Hiraoka M Harada H, Masunaga S, Hiraoka M Harada H, Masunaga S, Hiraoka M Genetic Screening of Upstream Activators of Hypoxia-inducible Factor 1 for the Devrlopment of Novel Anti-cancer Strategies Genetic Screening of Upstream Activators of Hypoxia-inducible Factor 1 for the Devrlopment of Novel Anti-cancer Strategies Genetic Screening of Upstream Activators of Hypoxia-inducible Factor 1 for the Devrlopment of Novel Anti-cancer Strategies Progress Report 2014, The Research Reactor Institute, Kyoto University, 6 Progress Report 2014, The Research Reactor Institute, Kyoto University, 6 Progress Report 2014, The Research Reactor Institute, Kyoto University, 6 2015 English Prompt report, short report, and research note, etc.(bulletin of university, research institution) Disclose to all
阿栄 高娃, 堀部 智久, 河野 雅之, 田畑 泰彦, 原田 浩, 平岡 眞寛, 川上 浩司 阿栄 高娃, 堀部 智久, 河野 雅之, 田畑 泰彦, 原田 浩, 平岡 眞寛, 川上 浩司 チオール化カルボキシメチルデキストランとのS-S結合によるEGFR2R-lyticハイブリッドペプチドの抗腫瘍効果の増強 チオール化カルボキシメチルデキストランとのS-S結合によるEGFR2R-lyticハイブリッドペプチドの抗腫瘍効果の増強 「第30回日本DDS学会学術集会」2014年7月30日-31日, 東京 「第30回日本DDS学会学術集会」2014年7月30日-31日, 東京 2014/07 Disclose to all
Harada H, Masunaga S, Hiraoka M Harada H, Masunaga S, Hiraoka M Harada H, Masunaga S, Hiraoka M DH3αOverexpression Promotes Malignant Tumor Growth by Inducing HIF・1Activity DH3αOverexpression Promotes Malignant Tumor Growth by Inducing HIF・1Activity DH3αOverexpression Promotes Malignant Tumor Growth by Inducing HIF・1Activity Progress Report 2013, The Research Reactor Institute, Kyoto University, 122 Progress Report 2013, The Research Reactor Institute, Kyoto University, 122 Progress Report 2013, The Research Reactor Institute, Kyoto University, 122 2014 English Prompt report, short report, and research note, etc.(bulletin of university, research institution) Disclose to all
阿栄 高娃, 堀部 智久, 河野 雅之, 佐藤 圭祐, 田畑 泰彦, 原田 浩, 平岡 眞寛, 川上 浩司 阿栄 高娃, 堀部 智久, 河野 雅之, 佐藤 圭祐, 田畑 泰彦, 原田 浩, 平岡 眞寛, 川上 浩司 ゼラチンハイドロゲルを用いたEGFR2R-lyticハイブリッドペプチドの徐放性注射製剤の開発 ゼラチンハイドロゲルを用いたEGFR2R-lyticハイブリッドペプチドの徐放性注射製剤の開発 「第29回日本DDS学会」 2013年7月4日―5日, 京都 「第29回日本DDS学会」 2013年7月4日―5日, 京都 2013/07 Disclose to all
Jason Boyang Wu, Chen Shao, Xiangyan Li, Peizhen Hu, Yi-Ting Chen, Xiaoliang Dou, Divya Sahu, Wei Li, Hiroshi Harada, Ruoxiang Wang, Haiyen E. Zhau, Leland W. K. Chung Jason Boyang Wu, Chen Shao, Xiangyan Li, Peizhen Hu, Yi-Ting Chen, Xiaoliang Dou, Divya Sahu, Wei Li, Hiroshi Harada, Ruoxiang Wang, Haiyen E. Zhau, Leland W. K. Chung Jason Boyang Wu, Chen Shao, Xiangyan Li, Peizhen Hu, Yi-Ting Chen, Xiaoliang Dou, Divya Sahu, Wei Li, Hiroshi Harada, Ruoxiang Wang, Haiyen E. Zhau, Leland W. K. Chung Hypoxia-mediated cancer imaging by a novel class of near-infrared (NIR) heptamethine cyanine dyes Hypoxia-mediated cancer imaging by a novel class of near-infrared (NIR) heptamethine cyanine dyes Hypoxia-mediated cancer imaging by a novel class of near-infrared (NIR) heptamethine cyanine dyes CANCER RESEARCH, 73, 8 CANCER RESEARCH, 73, 8 CANCER RESEARCH, 73, 8 2013/04 English Summary of the papers read (international conference) Disclose to all
小林 稔, 曽 麗華, 後藤 容子, 井上 実, 板坂 聡, 吉村 通央, 原田 浩, 平岡 真寛 小林 稔, 曽 麗華, 後藤 容子, 井上 実, 板坂 聡, 吉村 通央, 原田 浩, 平岡 真寛 IDH3はHIF-1alphaを安定化して腫瘍増殖を亢進する IDH3はHIF-1alphaを安定化して腫瘍増殖を亢進する 2013 Japanese Summary of the papers read (national conference and other science council) Disclose to all
Harada H, Masunaga S, Hiraoka M Harada H, Masunaga S, Hiraoka M Harada H, Masunaga S, Hiraoka M Upstream Activators of HIF-1 as Targets for Radiosensitization Upstream Activators of HIF-1 as Targets for Radiosensitization Upstream Activators of HIF-1 as Targets for Radiosensitization Progress Report 2012, The Research Reactor Institute, Kyoto University, 150 Progress Report 2012, The Research Reactor Institute, Kyoto University, 150 Progress Report 2012, The Research Reactor Institute, Kyoto University, 150 2013 English Prompt report, short report, and research note, etc.(bulletin of university, research institution) Disclose to all
H. Harada, S. Itasaka, K. Shibuya, M. Hiraoka H. Harada, S. Itasaka, K. Shibuya, M. Hiraoka H. Harada, S. Itasaka, K. Shibuya, M. Hiraoka Treatment regimen determines whether a HIF-1 inhibitor enhances or inhibits the effect of radiation therapy Treatment regimen determines whether a HIF-1 inhibitor enhances or inhibits the effect of radiation therapy Treatment regimen determines whether a HIF-1 inhibitor enhances or inhibits the effect of radiation therapy EJC SUPPLEMENTS, 7, 2, 155-155 EJC SUPPLEMENTS, 7, 2, 155-155 EJC SUPPLEMENTS, 7, 2, 155-155 2009/09 English Summary of the papers read (international conference) Disclose to all
S Kizaka-Kondoh, H Harada, M Hiraoka S Kizaka-Kondoh, H Harada, M Hiraoka S Kizaka-Kondoh, H Harada, M Hiraoka Anti-tumor effects of TAT-ODD caspase 3 fusion protein specifically stabilized in hypoxic tumor cells. Anti-tumor effects of TAT-ODD caspase 3 fusion protein specifically stabilized in hypoxic tumor cells. Anti-tumor effects of TAT-ODD caspase 3 fusion protein specifically stabilized in hypoxic tumor cells. CLINICAL CANCER RESEARCH, 7, 11, 3674S-3675S CLINICAL CANCER RESEARCH, 7, 11, 3674S-3675S CLINICAL CANCER RESEARCH, 7, 11, 3674S-3675S 2001/11 English Summary of the papers read (international conference) Disclose to all

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Title language:
Conference Activities & Talks
Title Title(Japanese) Title(English) Conference Conference(Japanese) Conference(English) Promotor Promotor(Japanese) Promotor(English) Date Language Assortment Disclose
低酸素と放射線の関わり[Invited] 低酸素と放射線の関わり [Invited] 第10回日本放射線腫瘍学会(JASTRO)放射線生物学セミナー 第10回日本放射線腫瘍学会(JASTRO)放射線生物学セミナー 2020/02/16 Japanese Public discourse, seminar, tutorial, course, lecture and others Disclose to all
放射線腫瘍学における低酸素バイオロジー.[Invited] 放射線腫瘍学における低酸素バイオロジー. [Invited] 第49回. 京都放射線腫瘍研究会 第49回. 京都放射線腫瘍研究会 2020/02/15 Japanese Oral presentation(keynote) Disclose to all
A link between activation of HIF-1 and defect in p53 in malignantprogression of cancers.[Invited] A link between activation of HIF-1 and defect in p53 in malignantprogression of cancers. [Invited] A link between activation of HIF-1 and defect in p53 in malignantprogression of cancers. [Invited] International Seminar on Stress Medicine and PrecisionHealthcare; from Hypoxia and DNA Damage Response to Therapeutic Intervention International Seminar on Stress Medicine and PrecisionHealthcare; from Hypoxia and DNA Damage Response to Therapeutic Intervention International Seminar on Stress Medicine and PrecisionHealthcare; from Hypoxia and DNA Damage Response to Therapeutic Intervention 2019/12/30 English Oral presentation(keynote) Disclose to all
新規HIF-1活性化因子の発現スクリーニングで明らかになったHIF-1活性制御機構[Invited] 新規HIF-1活性化因子の発現スクリーニングで明らかになったHIF-1活性制御機構 [Invited] 第42回日本分子生物学会年会 第42回日本分子生物学会年会 2019/12/06 Japanese Oral presentation(invited, special) Disclose to all
Radioresistance of hypoxic tumor cells; Lessons from hypoxiaand HIF-1 biology.[Invited] Radioresistance of hypoxic tumor cells; Lessons from hypoxiaand HIF-1 biology. [Invited] Radioresistance of hypoxic tumor cells; Lessons from hypoxiaand HIF-1 biology. [Invited] The 3rd isRTB. The 3rd isRTB. The 3rd isRTB. 2019/11/28 English Oral presentation(invited, special) Disclose to all
低酸素・腫瘍生物学研究で迫る癌治療増感.[Invited] 低酸素・腫瘍生物学研究で迫る癌治療増感. [Invited] 日本放射線腫瘍学会第32回学術大会. 名古屋 日本放射線腫瘍学会第32回学術大会. 名古屋 2019/11/21 Japanese Symposium workshop panel(nominated) Disclose to all
放射線治療効果の増強につなげる腫瘍生物学・低酸素生物学研究[Invited] 放射線治療効果の増強につなげる腫瘍生物学・低酸素生物学研究 [Invited] 第57回日本癌治療学会学術集会 第57回日本癌治療学会学術集会 2019/10/26 Japanese Oral presentation(invited, special) Disclose to all
Tumor hypoxia; its influences on malignant progression and therapyresistance of cancer cells[Invited] Tumor hypoxia; its influences on malignant progression and therapyresistance of cancer cells [Invited] Tumor hypoxia; its influences on malignant progression and therapyresistance of cancer cells [Invited] Special Seminar in Kobe University GraduateSchool of Medicine Special Seminar in Kobe University GraduateSchool of Medicine Special Seminar in Kobe University GraduateSchool of Medicine 2019/10/09 English Public discourse, seminar, tutorial, course, lecture and others Disclose to all
A link between HIF-1 and defect in p53 under hypoxic stress[Invited] A link between HIF-1 and defect in p53 under hypoxic stress [Invited] A link between HIF-1 and defect in p53 under hypoxic stress [Invited] The 78th Annual Meeting ofJapanese Cancer Association The 78th Annual Meeting ofJapanese Cancer Association The 78th Annual Meeting ofJapanese Cancer Association 2019/09/26 English Oral presentation(invited, special) Disclose to all
低酸素がん細胞の治療抵抗性と再発を担う能動的休眠制御[Invited] 低酸素がん細胞の治療抵抗性と再発を担う能動的休眠制御 [Invited] 第92回日本生化学会大会 第92回日本生化学会大会 2019/09/18 Japanese Oral presentation(invited, special) Disclose to all
Radioresistance of hypoxic tumor cells; Lessons from hypoxia& HIF-1 biology and beyond[Invited] Radioresistance of hypoxic tumor cells; Lessons from hypoxia& HIF-1 biology and beyond [Invited] Radioresistance of hypoxic tumor cells; Lessons from hypoxia& HIF-1 biology and beyond [Invited] The 16th International Congress of RadiationResearch 2019 (ICRR2019). The 16th International Congress of RadiationResearch 2019 (ICRR2019). 2019/08/29 English Oral presentation(invited, special) Disclose to all
がん抑制機構と低酸素応答機構をつなぐ新規遺伝子の同定と活用[Invited] がん抑制機構と低酸素応答機構をつなぐ新規遺伝子の同定と活用 [Invited] 第21回京都大学大学院生命科学研究科シンポジウム 第21回京都大学大学院生命科学研究科シンポジウム 2019/07/04 Japanese Symposium workshop panel(nominated) Disclose to all
分子腫瘍学・構造生物学・理論化学・臨床医学の融合によるがんの悪性進展制御因子に対するドラッグデザイン研究[Invited] 分子腫瘍学・構造生物学・理論化学・臨床医学の融合によるがんの悪性進展制御因子に対するドラッグデザイン研究 [Invited] 日本医療研究開発機構(AMED) 平成30年度 創薬基盤推進研究事業公開シンポジウム 日本医療研究開発機構(AMED) 平成30年度 創薬基盤推進研究事業公開シンポジウム 2019/01/28 Japanese Symposium workshop panel(nominated) Disclose to all
Functions of HIF-1 in tumor hypoxia and beyond[Invited] Functions of HIF-1 in tumor hypoxia and beyond [Invited] Functions of HIF-1 in tumor hypoxia and beyond [Invited] Bio-Group Symposium 2018. Taipei. Bio-Group Symposium 2018. Taipei. Bio-Group Symposium 2018. Taipei. 2018/12/23 English Symposium workshop panel(nominated) Disclose to all
p53変異型腫瘍の悪性進展を抑制するPPI阻害剤創製に向けた試み[Invited] p53変異型腫瘍の悪性進展を抑制するPPI阻害剤創製に向けた試み [Invited] 第1回モダリティ創薬デザイン研究会シンポジウム 第1回モダリティ創薬デザイン研究会シンポジウム 2018/11/26 Japanese Symposium workshop panel(nominated) Disclose to all
低酸素/HIF-1バイオロジーを基軸とする放射線腫瘍生物学研究 -放生研の研究プラットフォームを交えて-.[Invited] 低酸素/HIF-1バイオロジーを基軸とする放射線腫瘍生物学研究 -放生研の研究プラットフォームを交えて-. [Invited] 第61回日本放射線影響学会. 第61回日本放射線影響学会. 2018/11/07 Japanese Symposium workshop panel(nominated) Disclose to all
腫瘍低酸素に係る基礎研究と臨床応用[Invited] 腫瘍低酸素に係る基礎研究と臨床応用 [Invited] 腫瘍低酸素に係る基礎研究と臨床応用 腫瘍低酸素に係る基礎研究と臨床応用 2018/10/13 Japanese Symposium workshop panel(nominated) Disclose to all
臓器間のDNA損傷耐用能の違いから迫る”宇宙放射線克服に向けた基盤構築[Invited] 臓器間のDNA損傷耐用能の違いから迫る”宇宙放射線克服に向けた基盤構築 [Invited] 臓器間のDNA損傷耐用能の違いから迫る”宇宙放射線克服に向けた基盤構築 [Invited] 日本宇宙生物科学会第32回大会 日本宇宙生物科学会第32回大会 2018/09/23 Japanese Symposium workshop panel(nominated) Disclose to all
Function of HIF-1 in tumor hypoxia and beyond[Invited] Function of HIF-1 in tumor hypoxia and beyond [Invited] Function of HIF-1 in tumor hypoxia and beyond [Invited] 東北大学大学院薬学研究科セミナー 東北大学大学院薬学研究科セミナー 2018/09/21 Japanese Public discourse, seminar, tutorial, course, lecture and others Disclose to all
Radioresistance of hypoxic tumor cells[Invited] Radioresistance of hypoxic tumor cells [Invited] Radioresistance of hypoxic tumor cells [Invited] Radiation Biology School, Hokkaido Summer Institute 2018 Radiation Biology School, Hokkaido Summer Institute 2018 Radiation Biology School, Hokkaido Summer Institute 2018 2018/08/03 English Public discourse, seminar, tutorial, course, lecture and others Disclose to all
悪性固形腫瘍内低酸素微小環境と放射線感受性[Invited] 悪性固形腫瘍内低酸素微小環境と放射線感受性 [Invited] AMED創薬基盤推進研究事業 CMB育成事業〜別府リトリート合宿 AMED創薬基盤推進研究事業 CMB育成事業〜別府リトリート合宿 2018/07/27 Japanese Public discourse, seminar, tutorial, course, lecture and others Disclose to all
HIF-1 and Tumor Progression[Invited] HIF-1 and Tumor Progression [Invited] HIF-1 and Tumor Progression [Invited] 24th Congress of International Union of Biochemistry and Molecular Biology 24th Congress of International Union of Biochemistry and Molecular Biology 24th Congress of International Union of Biochemistry and Molecular Biology 2018/06/05 English Symposium workshop panel(nominated) Disclose to all
HIF-1 in tumor hypoxia and beyond[Invited] HIF-1 in tumor hypoxia and beyond [Invited] 第24回癌治療増感研究会 第24回癌治療増感研究会 2018/05/26 Japanese Oral presentation(keynote) Disclose to all
生体内低酸素微小環境と放射線感受性[Invited] 生体内低酸素微小環境と放射線感受性 [Invited] 京都大学大学院生命科学研究科・放射線生物研究センター統合記念シンポジウム 京都大学大学院生命科学研究科・放射線生物研究センター統合記念シンポジウム 2018/05/25 Japanese Symposium workshop panel(nominated) Disclose to all
照準を合わせろ! がんに対する放射線治療の現状と課題[Invited] 照準を合わせろ! がんに対する放射線治療の現状と課題 [Invited] 第13回京都大学附置研究所・センターシンポジウム;京都からの挑戦 -地球社会の調和ある共存に向けて- 第13回京都大学附置研究所・センターシンポジウム;京都からの挑戦 -地球社会の調和ある共存に向けて- 2018/03/17 Japanese Public discourse, seminar, tutorial, course, lecture and others Disclose to all
Hypoxic Microenvironments in Malignant Solid Tumors[Invited] Hypoxic Microenvironments in Malignant Solid Tumors [Invited] Hypoxic Microenvironments in Malignant Solid Tumors [Invited] International Mini-symposium on Organs under Stress International Mini-symposium on Organs under Stress International Mini-symposium on Organs under Stress 2018/02/16 English Symposium workshop panel(nominated) Disclose to all
がん・低酸素・HIF-1[Invited] がん・低酸素・HIF-1 [Invited] 国立京都医療センター臨床研究センター特別講演会 国立京都医療センター臨床研究センター特別講演会 2018/02/05 Japanese Public discourse, seminar, tutorial, course, lecture and others Disclose to all
腫瘍内微小環境と放射線感受性・抵抗性[Invited] 腫瘍内微小環境と放射線感受性・抵抗性 [Invited] JASTRO第8回放射線生物学セミナー JASTRO第8回放射線生物学セミナー 2018/01/20 Japanese Public discourse, seminar, tutorial, course, lecture and others Disclose to all
細胞の低酸素応答を担う新規遺伝子の作用機序と機能.[Invited] 細胞の低酸素応答を担う新規遺伝子の作用機序と機能. [Invited] 2017/12/08 Japanese Symposium workshop panel(nominated) Disclose to all
がんに対する放射線治療の現状・課題・私たちの取り組み;低酸素バイオロジーの視点から[Invited] がんに対する放射線治療の現状・課題・私たちの取り組み;低酸素バイオロジーの視点から [Invited] 富山大学医歯薬総合研究科特別講演会 富山大学医歯薬総合研究科特別講演会 2017/11/24 Japanese Public discourse, seminar, tutorial, course, lecture and others Disclose to all
How can we overcome tumor radioresistance; lessons from hypoxia biology.[Invited] How can we overcome tumor radioresistance; lessons from hypoxia biology. [Invited] How can we overcome tumor radioresistance; lessons from hypoxia biology. [Invited] The 1st isRTB The 1st isRTB The 1st isRTB 2017/10/31 English Symposium workshop panel(nominated) Disclose to all
がんに対する放射線治療の現状と課題[Invited] がんに対する放射線治療の現状と課題 [Invited] 知の拠点セミナー. 知の拠点セミナー. 2017/10/20 Japanese Public discourse, seminar, tutorial, course, lecture and others Disclose to all
Radioresistance of Cancer Cells; Lessons from HIF-1 Biology[Invited] Radioresistance of Cancer Cells; Lessons from HIF-1 Biology [Invited] 放射線生物学セミナー in Gifu. 岐阜 放射線生物学セミナー in Gifu. 岐阜 2017/10/16 Japanese Public discourse, seminar, tutorial, course, lecture and others Disclose to all
HIF-1バイオロジーで迫るがんの放射線抵抗性[Invited] HIF-1バイオロジーで迫るがんの放射線抵抗性 [Invited] 若手放射線生物研究専門研究会 若手放射線生物研究専門研究会 2017/09/02 Japanese Symposium workshop panel(nominated) Disclose to all
HIF-1の生物学:基礎研究から創薬研究への展開[Invited] HIF-1の生物学:基礎研究から創薬研究への展開 [Invited] 新規分子標的治療薬創薬に向けた大学発ベンチャー基盤の確立シンポジウム 新規分子標的治療薬創薬に向けた大学発ベンチャー基盤の確立シンポジウム 2017/09/01 Japanese Oral presentation(keynote) Disclose to all
がんの悪性進展と治療抵抗性を担うHIF-1を中心とする遺伝子ネットワーク[Invited] がんの悪性進展と治療抵抗性を担うHIF-1を中心とする遺伝子ネットワーク [Invited] 第5回低酸素研究会 第5回低酸素研究会 2017/07/29 Japanese Symposium workshop panel(nominated) Disclose to all
がん細胞のグルコース代謝 がん細胞のグルコース代謝 第19回京都大学大学院生命科学研究科シンポジウム 第19回京都大学大学院生命科学研究科シンポジウム 2017/07/07 Japanese Public discourse, seminar, tutorial, course, lecture and others Disclose to all
Tumor hypoxia; an imaging and therapeutic target of interest for innovative radiation therapy[Invited] Tumor hypoxia; an imaging and therapeutic target of interest for innovative radiation therapy [Invited] Tumor hypoxia; an imaging and therapeutic target of interest for innovative radiation therapy [Invited] The 3rd Bordeaux-Kyoto Symposium The 3rd Bordeaux-Kyoto Symposium The 3rd Bordeaux-Kyoto Symposium 2017/06/29 English Symposium workshop panel(nominated) Disclose to all
悪性固形腫瘍内の低酸素環境 -放射線生物学の視点から-[Invited] 悪性固形腫瘍内の低酸素環境 -放射線生物学の視点から- [Invited] 日本放射線腫瘍学会 第46回 放射線による制癌シンポジウム 日本放射線腫瘍学会 第46回 放射線による制癌シンポジウム 2017/06/17 Japanese Oral presentation(keynote) Disclose to all
腫瘍の微小環境と放射線感受性[Invited] 腫瘍の微小環境と放射線感受性 [Invited] 日本放射線腫瘍学会 第7回 放射線生物学セミナー 日本放射線腫瘍学会 第7回 放射線生物学セミナー 2017/01/28 Japanese Public discourse, seminar, tutorial, course, lecture and others Disclose to all
現代生物学が放射線治療に指し示すもの[Invited] 現代生物学が放射線治療に指し示すもの [Invited] 九州放射線治療システム研究会 九州放射線治療システム研究会 2017/01/28 Japanese Oral presentation(keynote) Disclose to all
IDH3-HIF-1経路によるがん細胞の糖代謝リプログラミング[Invited] IDH3-HIF-1経路によるがん細胞の糖代謝リプログラミング [Invited] 日本がん分子標的治療学会 第12回トランスレーショナルリサーチワークショップ 日本がん分子標的治療学会 第12回トランスレーショナルリサーチワークショップ 2017/01/18 Japanese Oral presentation(invited, special) Disclose to all
がんの悪性化と治療抵抗性を左右する「腫瘍内微小環境」[Invited] がんの悪性化と治療抵抗性を左右する「腫瘍内微小環境」 [Invited] 京都大学丸の内セミナー 京都大学丸の内セミナー 2016/12/02 Japanese Public discourse, seminar, tutorial, course, lecture and others Disclose to all
がん・低酸素・HIF-1[Invited] がん・低酸素・HIF-1 [Invited] 京都薬科大学病態生理学セミナー 京都薬科大学病態生理学セミナー 2016/11/25 Japanese Public discourse, seminar, tutorial, course, lecture and others Disclose to all
生物研究の方向性; 放射線腫瘍学における生物研究[Invited] 生物研究の方向性; 放射線腫瘍学における生物研究 [Invited] 日本放射線腫瘍学会第29回学術大会 日本放射線腫瘍学会第29回学術大会 2016/11/25 Japanese Symposium workshop panel(nominated) Disclose to all
悪性固形腫瘍内の微小環境と放射線抵抗性[Invited] 悪性固形腫瘍内の微小環境と放射線抵抗性 [Invited] 熊本放射線腫瘍研究会 熊本放射線腫瘍研究会 2016/11/18 Japanese Oral presentation(keynote) Disclose to all
がん・低酸素・HIF-1.[Invited] がん・低酸素・HIF-1. [Invited] Forum in Dojin Forum in Dojin 2016/10/28 Japanese Public discourse, seminar, tutorial, course, lecture and others Disclose to all
HIF-1を中心とする活性酸素ストレス応答の分子基盤と機能[Invited] HIF-1を中心とする活性酸素ストレス応答の分子基盤と機能 [Invited] 日本放射線影響学会第59回大会 日本放射線影響学会第59回大会 2016/10/27 Japanese Oral presentation(invited, special) Disclose to all
Function of the UCHL1-HIF-1 Axis in Distant Metastasis and Radioresistance of Cancer Cells.[Invited] Function of the UCHL1-HIF-1 Axis in Distant Metastasis and Radioresistance of Cancer Cells. [Invited] Function of the UCHL1-HIF-1 Axis in Distant Metastasis and Radioresistance of Cancer Cells. [Invited] International Symposium of Radiation Biology Center, Kyoto University 2016. International Symposium of Radiation Biology Center, Kyoto University 2016. International Symposium of Radiation Biology Center, Kyoto University 2016. 2016/09/01 English Oral presentation(invited, special) Disclose to all
放射線生物学・最近の話題 -低酸素とがん幹細胞-[Invited] 放射線生物学・最近の話題 -低酸素とがん幹細胞- [Invited] 日本放射線腫瘍学会(JASTRO)夏季セミナー 日本放射線腫瘍学会(JASTRO)夏季セミナー 2016/08/07 Japanese Public discourse, seminar, tutorial, course, lecture and others Disclose to all
がん細胞の糖代謝経路と放射線抵抗性のクロストーク[Invited] がん細胞の糖代謝経路と放射線抵抗性のクロストーク [Invited] 第45回放射線による制癌シンポジウム 第45回放射線による制癌シンポジウム 2016/07/15 Japanese Oral presentation(invited, special) Disclose to all
Radioresistance of Cancer Cells; Lessons from HIF-1 Biology.[Invited] Radioresistance of Cancer Cells; Lessons from HIF-1 Biology. [Invited] Radioresistance of Cancer Cells; Lessons from HIF-1 Biology. [Invited] Annual Meeting of Association for Radiation Research 2016 Annual Meeting of Association for Radiation Research 2016 Annual Meeting of Association for Radiation Research 2016 2016/06/29 English Symposium workshop panel(nominated) Disclose to all
Tumor Hypoxia; a Potent Inducer of Malignant Phenotypes and Radioresistance of Cancer Cells[Invited] Tumor Hypoxia; a Potent Inducer of Malignant Phenotypes and Radioresistance of Cancer Cells [Invited] Tumor Hypoxia; a Potent Inducer of Malignant Phenotypes and Radioresistance of Cancer Cells [Invited] The 2nd KU RBC-CEA Joint Workshop The 2nd KU RBC-CEA Joint Workshop The 2nd KU RBC-CEA Joint Workshop 2016/04/11 English Symposium workshop panel(nominated) Disclose to all
低酸素バイオロジーで迫るがん細胞の放射線抵抗性獲得機構[Invited] 低酸素バイオロジーで迫るがん細胞の放射線抵抗性獲得機構 [Invited] 日本放射線影響学会評議員学術講演会 日本放射線影響学会評議員学術講演会 2016/03/29 Japanese Public discourse, seminar, tutorial, course, lecture and others Disclose to all
低酸素バイオロジーへのいざない[Invited] 低酸素バイオロジーへのいざない [Invited] 幹細胞・がん・エピゲノムに関する合同リトリート 幹細胞・がん・エピゲノムに関する合同リトリート 2016/03/07 Japanese Public discourse, seminar, tutorial, course, lecture and others Disclose to all
がん細胞の放射線抵抗性の理解[Invited] がん細胞の放射線抵抗性の理解 [Invited] 第2回松島シンポジウム 第2回松島シンポジウム 2016/03/04 Japanese Oral presentation(invited, special) Disclose to all
がん細胞の糖代謝経路リプログラミングと放射線抵抗性[Invited] がん細胞の糖代謝経路リプログラミングと放射線抵抗性 [Invited] 癌治療増感研究シンポジウム 癌治療増感研究シンポジウム 2016/02/04 Japanese Symposium workshop panel(nominated) Disclose to all
Functional and Mechianistic Relationship between HIF-1 and Tumor Radioresistance.[Invited] Functional and Mechianistic Relationship between HIF-1 and Tumor Radioresistance. [Invited] Functional and Mechianistic Relationship between HIF-1 and Tumor Radioresistance. [Invited] GDN Radiation Biology and Oncology GDN Radiation Biology and Oncology GDN Radiation Biology and Oncology 2016/01/28 Japanese Oral presentation(invited, special) Disclose to all
HIF-1によるがんの悪性化と治療抵抗性.[Invited] HIF-1によるがんの悪性化と治療抵抗性. [Invited] 愛知県がんセンター研究所 特別招聘セミナー 愛知県がんセンター研究所 特別招聘セミナー 2016/01/18 Japanese Public discourse, seminar, tutorial, course, lecture and others Disclose to all
Tumor Hypoxia; a Potent Inducer of Tumor Malignant Phenotypes.[Invited] Tumor Hypoxia; a Potent Inducer of Tumor Malignant Phenotypes. [Invited] Tumor Hypoxia; a Potent Inducer of Tumor Malignant Phenotypes. [Invited] International Symposium@The 4th Military Medical University. International Symposium@The 4th Military Medical University. International Symposium@The 4th Military Medical University. 2016/01/07 English Public discourse, seminar, tutorial, course, lecture and others Disclose to all
Importance of Hypoxic Niche; Lessons from Hypoxia and Cancer Biology.[Invited] Importance of Hypoxic Niche; Lessons from Hypoxia and Cancer Biology. [Invited] Importance of Hypoxic Niche; Lessons from Hypoxia and Cancer Biology. [Invited] Biochemistry and Molecular Biology 2015 (BMB2015) Biochemistry and Molecular Biology 2015 (BMB2015) Biochemistry and Molecular Biology 2015 (BMB2015) 2015/12/02 Japanese Symposium workshop panel(nominated) Disclose to all
Molecular Biology for the Advancement of Cancer Radiotherapy; in the Past and the Future.[Invited] Molecular Biology for the Advancement of Cancer Radiotherapy; in the Past and the Future. [Invited] Molecular Biology for the Advancement of Cancer Radiotherapy; in the Past and the Future. [Invited] 日本放射線腫瘍学会 第28回学術大会 日本放射線腫瘍学会 第28回学術大会 2015/11/19 Japanese Symposium workshop panel(nominated) Disclose to all
Tumor Hypoxia, a Potent Inducer of Malignant Phenotypes of Cancer Cells[Invited] Tumor Hypoxia, a Potent Inducer of Malignant Phenotypes of Cancer Cells [Invited] Tumor Hypoxia, a Potent Inducer of Malignant Phenotypes of Cancer Cells [Invited] The 2nd IFOM-Kyoto University Joint International Symposium. The 2nd IFOM-Kyoto University Joint International Symposium. The 2nd IFOM-Kyoto University Joint International Symposium. 2015/10/07 English Symposium workshop panel(nominated) Disclose to all
IDH3-HIF-1経路によるがん細胞の糖代謝リプログラミング[Invited] IDH3-HIF-1経路によるがん細胞の糖代謝リプログラミング [Invited] 第3回癌と代謝研究会 第3回癌と代謝研究会 2015/07/15 Japanese Symposium workshop panel(nominated) Disclose to all
Oxygen-deficiency; Good or Bad for Cancer Therapy?[Invited] Oxygen-deficiency; Good or Bad for Cancer Therapy? [Invited] Oxygen-deficiency; Good or Bad for Cancer Therapy? [Invited] The 97th Kyoto University Hakubi Seminar. The 97th Kyoto University Hakubi Seminar. The 97th Kyoto University Hakubi Seminar. 2015/07/07 English Oral presentation(invited, special) Disclose to all
低酸素バイオロジーに基づく放射線治療の新展開[Invited] 低酸素バイオロジーに基づく放射線治療の新展開 [Invited] 日本医学放射線学会(JRS)中四国地方会 放射線治療懇話会 特別講演 日本医学放射線学会(JRS)中四国地方会 放射線治療懇話会 特別講演 2015/06/27 Japanese Oral presentation(keynote) Disclose to all
放射線腫瘍学の視点でみる「がん幹細胞」[Invited] 放射線腫瘍学の視点でみる「がん幹細胞」 [Invited] 広島大学病院放射線治療講演会 広島大学病院放射線治療講演会 2015/06/25 Japanese Public discourse, seminar, tutorial, course, lecture and others Disclose to all
低酸素バイオロジー研究に於けるデータベースの活用例[Invited] 低酸素バイオロジー研究に於けるデータベースの活用例 [Invited] 第13回 がんとハイポキシア研究会 第13回 がんとハイポキシア研究会 2015/06/06 Japanese Symposium workshop panel(nominated) Disclose to all
Tumor Hypoxia and Radioresistance[Invited] Tumor Hypoxia and Radioresistance [Invited] Tumor Hypoxia and Radioresistance [Invited] The 15th International Congress for Radiation Research (ICRR2015) The 15th International Congress for Radiation Research (ICRR2015) The 15th International Congress for Radiation Research (ICRR2015) 2015/05/28 English Symposium workshop panel(nominated) Disclose to all
低酸素生物学に基づく生体内低酸素の可視化[Invited] 低酸素生物学に基づく生体内低酸素の可視化 [Invited] 第54回日本生体医工学会 第54回日本生体医工学会 2015/05/07 Japanese Symposium workshop panel(nominated) Disclose to all
がん細胞の低酸素応答機構の理解と利用[Invited] がん細胞の低酸素応答機構の理解と利用 [Invited] 京都大学大学院医学研究科皮膚科学講座セミナー 京都大学大学院医学研究科皮膚科学講座セミナー 2015/04/30 Japanese Public discourse, seminar, tutorial, course, lecture and others Disclose to all
がん幹細胞と腫瘍内低酸素 -癌の診断と治療における重要性と展望-[Invited] がん幹細胞と腫瘍内低酸素 -癌の診断と治療における重要性と展望- [Invited] 第74回 日本医学放射線学会 第74回 日本医学放射線学会 2015/04/18 Japanese Public discourse, seminar, tutorial, course, lecture and others Disclose to all
がん細胞の低酸素応答機構の理解と利用 がん細胞の低酸素応答機構の理解と利用 京都大学再生医科学研究所セミナー 京都大学再生医科学研究所セミナー 2015/04/11 Japanese Public discourse, seminar, tutorial, course, lecture and others Disclose to all
腫瘍内低酸素領域・HIF-1活性を診る意義 -低酸素バイオロジー研究で明らかになったがんの悪性形質獲得メカニズム-.[Invited] 腫瘍内低酸素領域・HIF-1活性を診る意義 -低酸素バイオロジー研究で明らかになったがんの悪性形質獲得メカニズム-. [Invited] 第17回国際癌治療増感シンポジウム 第17回国際癌治療増感シンポジウム 2015/02/07 Japanese Symposium workshop panel(nominated) Disclose to all
がんの微小環境研究を通して同定された新たな治療標的[Invited] がんの微小環境研究を通して同定された新たな治療標的 [Invited] 第3回国際先端生物学・医学・工学会議 第3回国際先端生物学・医学・工学会議 2015/01/16 Japanese Oral presentation(keynote) Disclose to all
Warburg効果(がん細胞の好気的解糖)・温故知新[Invited] Warburg効果(がん細胞の好気的解糖)・温故知新 [Invited] 東京医科歯科大学・キャンサーボード/大学院特別講義 東京医科歯科大学・キャンサーボード/大学院特別講義 2014/11/20 Japanese Public discourse, seminar, tutorial, course, lecture and others Disclose to all
UCHL1 provides novel diagnostic and antimetastatic strategy due to its deubiquitinating effect on HIF-1alpha[Invited] UCHL1 provides novel diagnostic and antimetastatic strategy due to its deubiquitinating effect on HIF-1alpha [Invited] UCHL1 provides novel diagnostic and antimetastatic strategy due to its deubiquitinating effect on HIF-1alpha [Invited] Hypoxia Meeting Hypoxia Meeting Hypoxia Meeting 2014/07/04 English Oral presentation(invited, special) Disclose to all
IDH3によるがんの代謝リプログラミング機構の解明と新たな治療法確立への展開[Invited] IDH3によるがんの代謝リプログラミング機構の解明と新たな治療法確立への展開 [Invited] 第18回日本がん分子標的治療学会学術総会 第18回日本がん分子標的治療学会学術総会 2014/06/26 Japanese Symposium workshop panel(nominated) Disclose to all
HIF-1 as a Rational Target for Cancer Therapy[Invited] HIF-1 as a Rational Target for Cancer Therapy [Invited] HIF-1 as a Rational Target for Cancer Therapy [Invited] University of Oxford, Oxford Institute for Radiation Oncology Seminar University of Oxford, Oxford Institute for Radiation Oncology Seminar University of Oxford, Oxford Institute for Radiation Oncology Seminar 2014/05/29 English Public discourse, seminar, tutorial, course, lecture and others Disclose to all
Importance of HIF-1 in Radiation Oncology[Invited] Importance of HIF-1 in Radiation Oncology [Invited] Importance of HIF-1 in Radiation Oncology [Invited] The University of Oxford. Gray Institute for Radiation Oncology & Biology Seminar The University of Oxford. Gray Institute for Radiation Oncology & Biology Seminar The University of Oxford. Gray Institute for Radiation Oncology & Biology Seminar 2014/04/07 English Public discourse, seminar, tutorial, course, lecture and others Disclose to all
FIRST Joint International Symposium; Overcoming Intractable Cancer-a new path to the future[Invited] FIRST Joint International Symposium; Overcoming Intractable Cancer-a new path to the future [Invited] FIRST Joint International Symposium; Overcoming Intractable Cancer-a new path to the future [Invited] Metabolic Reprogramming of Cancer Cells; a Rational Target for the Diagnosis and Treatment of Cancers. Metabolic Reprogramming of Cancer Cells; a Rational Target for the Diagnosis and Treatment of Cancers. Metabolic Reprogramming of Cancer Cells; a Rational Target for the Diagnosis and Treatment of Cancers. 2014/02/24 English Symposium workshop panel(nominated) Disclose to all
放射線腫瘍学における分子生物学的実験法[Invited] 放射線腫瘍学における分子生物学的実験法 [Invited] 日本放射線腫瘍学会 第4回生物学セミナー 日本放射線腫瘍学会 第4回生物学セミナー 2014/01/25 Japanese Public discourse, seminar, tutorial, course, lecture and others Disclose to all
低酸素バイオロジーに基づく放射線治療の新展開[Invited] 低酸素バイオロジーに基づく放射線治療の新展開 [Invited] 北里大学がんプロフェッショナル養成プラン セミナー 北里大学がんプロフェッショナル養成プラン セミナー 北里大学がんプロフェッショナル養成プラン 北里大学がんプロフェッショナル養成プラン 2013/11/23 Japanese Public discourse, seminar, tutorial, course, lecture and others Disclose to all
放射線生物学・最近の話題[Invited] 放射線生物学・最近の話題 [Invited] 第26回 日本放射線腫瘍学会学術総会 第26回 日本放射線腫瘍学会学術総会 日本放射線腫瘍学会 日本放射線腫瘍学会 2013/10/19 Japanese Public discourse, seminar, tutorial, course, lecture and others Disclose to all
低酸素がん細胞を治療標的とする根拠[Invited] 低酸素がん細胞を治療標的とする根拠 [Invited] 日本放射線影響学会 第56回大会 日本放射線影響学会 第56回大会 日本放射線影響学会 日本放射線影響学会 2013/10/18 Japanese Symposium workshop panel(nominated) Disclose to all
Molecular Mechanism behind Tumor Radioresistance; Lessons from Hypoxia Biology[Invited] Molecular Mechanism behind Tumor Radioresistance; Lessons from Hypoxia Biology [Invited] Molecular Mechanism behind Tumor Radioresistance; Lessons from Hypoxia Biology [Invited] The 72nd Annual Meeting of the Japanese Cancer Association, International Symposium Session The 72nd Annual Meeting of the Japanese Cancer Association, International Symposium Session The 72nd Annual Meeting of the Japanese Cancer Association, International Symposium Session 2013/10/03 English Symposium workshop panel(nominated) Disclose to all
低酸素バイオロジーで迫るがんの放射線抵抗性機構の解明[Invited] 低酸素バイオロジーで迫るがんの放射線抵抗性機構の解明 [Invited] 第42回放射線による制癌シンポジウム 第42回放射線による制癌シンポジウム 日本放射線腫瘍学会 生物部会 日本放射線腫瘍学会 生物部会 2013/07/05 Japanese Symposium workshop panel(nominated) Disclose to all
Molecular Mechanism behind Tumor Recurrence after Radiation Therapy; Lessons from Hypoxia Biology[Invited] Molecular Mechanism behind Tumor Recurrence after Radiation Therapy; Lessons from Hypoxia Biology [Invited] Molecular Mechanism behind Tumor Recurrence after Radiation Therapy; Lessons from Hypoxia Biology [Invited] The 3rd Asian Congress of Radiation Research The 3rd Asian Congress of Radiation Research The 3rd Asian Congress of Radiation Research 2013/05/13 English Symposium workshop panel(nominated) Disclose to all
新規HIF-1活性化因子の治療標的としての有用性[Invited] 新規HIF-1活性化因子の治療標的としての有用性 [Invited] 第15回癌治療増感研究シンポジウム 第15回癌治療増感研究シンポジウム 国際癌治療増感研究協会 国際癌治療増感研究協会 2013/02/09 Japanese Symposium workshop panel(nominated) Disclose to all
放射線腫瘍学における分子生物学的実験法[Invited] 放射線腫瘍学における分子生物学的実験法 [Invited] 日本放射線腫瘍学会 第3回生物学セミナー 日本放射線腫瘍学会 第3回生物学セミナー 日本放射線腫瘍学会 日本放射線腫瘍学会 2013/02/02 Japanese Public discourse, seminar, tutorial, course, lecture and others Disclose to all
放射線腫瘍学における低酸素バイオロジー[Invited] 放射線腫瘍学における低酸素バイオロジー [Invited] 東京医科歯科大学・大学院特別講義/キャンサーボードミーティング 東京医科歯科大学・大学院特別講義/キャンサーボードミーティング 東京医科歯科大学・大学院特別講義/キャンサーボード 東京医科歯科大学・大学院特別講義/キャンサーボード 2012/10/18 Japanese Public discourse, seminar, tutorial, course, lecture and others Disclose to all
Cancer cells that acquire HIF-1 activity after radiation therapy cause local tumor recurrence after radiation therapy[Invited] Cancer cells that acquire HIF-1 activity after radiation therapy cause local tumor recurrence after radiation therapy [Invited] Cancer cells that acquire HIF-1 activity after radiation therapy cause local tumor recurrence after radiation therapy [Invited] The 71st Annual Meeting of Japanese Cancer Association, International Symposium Session The 71st Annual Meeting of Japanese Cancer Association, International Symposium Session The 71st Annual Meeting of Japanese Cancer Association, International Symposium Session 2012/09/19 English Symposium workshop panel(nominated) Disclose to all
HIF-1陰性低酸素がん細胞はS期への細胞周期の移行により放射線抵抗性を獲得する[Invited] HIF-1陰性低酸素がん細胞はS期への細胞周期の移行により放射線抵抗性を獲得する [Invited] 日本放射線影響学会第55回大会 日本放射線影響学会第55回大会 日本放射線影響学会 日本放射線影響学会 2012/09/06 Japanese Symposium workshop panel(nominated) Disclose to all
がん細胞の動きを捉える[Invited] がん細胞の動きを捉える [Invited] 京都大学基礎物理学研究所主導研究会2012 京都大学基礎物理学研究所主導研究会2012 京都大学基礎物理学研究所 京都大学基礎物理学研究所 2012/08/09 Japanese Oral presentation(invited, special) Disclose to all
Function of Hypoxia-Inducible Factor 1 in Tumor Recurrence after Radiation Therapy; Lessons from Hypoxia Biology[Invited] Function of Hypoxia-Inducible Factor 1 in Tumor Recurrence after Radiation Therapy; Lessons from Hypoxia Biology [Invited] Function of Hypoxia-Inducible Factor 1 in Tumor Recurrence after Radiation Therapy; Lessons from Hypoxia Biology [Invited] The 31st Sapporo International Cancer Symposium The 31st Sapporo International Cancer Symposium The 31st Sapporo International Cancer Symposium 2012/07/23 English Symposium workshop panel(nominated) Disclose to all
Molecular Mechanism behind Tumor Recurrence after Radiation Therapy[Invited] Molecular Mechanism behind Tumor Recurrence after Radiation Therapy [Invited] 京都大学 再生医療臓器再建医学コースミーティング 京都大学 再生医療臓器再建医学コースミーティング 京都大学 iPS細胞研究所 京都大学 iPS細胞研究所 2012/03/11 Japanese Public discourse, seminar, tutorial, course, lecture and others Disclose to all
HIF-1-mediated Cellular Dynamics in Tumor Recurrence after Radiation Therapy[Invited] HIF-1-mediated Cellular Dynamics in Tumor Recurrence after Radiation Therapy [Invited] HIF-1-mediated Cellular Dynamics in Tumor Recurrence after Radiation Therapy [Invited] 2nd Symposium for ICDO Kyoto Univ 2nd Symposium for ICDO Kyoto Univ 2nd Symposium for ICDO Kyoto Univ 2012/03/01 English Symposium workshop panel(nominated) Disclose to all
低酸素細胞を標的としたアプローチ[Invited] 低酸素細胞を標的としたアプローチ [Invited] 第14回 国際癌治療増感研究 第14回 国際癌治療増感研究 国際癌治療増感研究協会 国際癌治療増感研究協会 2012/02/10 Japanese Symposium workshop panel(nominated) Disclose to all
放射線治療後のがん局所再発におけるhypoxia-inducible factor 1 (HIF-1)の機能[Invited] 放射線治療後のがん局所再発におけるhypoxia-inducible factor 1 (HIF-1)の機能 [Invited] 53回 日本放射線影響学会学術総会 53回 日本放射線影響学会学術総会 日本放射線影響学会 日本放射線影響学会 2011/11/18 Japanese Symposium workshop panel(nominated) Disclose to all
放射線治療後の腫瘍局所再発における腫瘍低酸素とHIF-1の役割[Invited] 放射線治療後の腫瘍局所再発における腫瘍低酸素とHIF-1の役割 [Invited] 京都府立医科大学 細胞生理学教室セミナー 京都府立医科大学 細胞生理学教室セミナー 京都府立医科大学 細胞生理学教室 京都府立医科大学 細胞生理学教室 2011/10/19 Japanese Public discourse, seminar, tutorial, course, lecture and others Disclose to all
放射線治療後のがん再発機構の解明とその克服[Invited] 放射線治療後のがん再発機構の解明とその克服 [Invited] 第2回 芝蘭会産学情報交換会 第2回 芝蘭会産学情報交換会 京都大学 芝蘭会 京都大学 芝蘭会 2011/10/12 Japanese Public discourse, seminar, tutorial, course, lecture and others Disclose to all
放射線治療後のがん再発機構の解明とその克服 -低酸素バイオロジーと放射線腫瘍学の接点-[Invited] 放射線治療後のがん再発機構の解明とその克服 -低酸素バイオロジーと放射線腫瘍学の接点- [Invited] 名古屋市立大学大学院システム自然科学研究科 田上研究室(クロマチン制御学)セミナー 名古屋市立大学大学院システム自然科学研究科 田上研究室(クロマチン制御学)セミナー 名古屋市立大学大学院システム自然科学研究科 名古屋市立大学大学院システム自然科学研究科 2011/09/30 Japanese Public discourse, seminar, tutorial, course, lecture and others Disclose to all
Molecular Mechanism behind HIF-1-mediated Radioresistance and Postirradiation Recurrence of Malignant Solid Tumors[Invited] Molecular Mechanism behind HIF-1-mediated Radioresistance and Postirradiation Recurrence of Malignant Solid Tumors [Invited] Molecular Mechanism behind HIF-1-mediated Radioresistance and Postirradiation Recurrence of Malignant Solid Tumors [Invited] The 14th International Congress of Radiation Research The 14th International Congress of Radiation Research The 14th International Congress of Radiation Research 2011/08/30 English Symposium workshop panel(nominated) Disclose to all
光イメージングで迫る腫瘍低酸素がん細胞の動態とがん再発への寄与[Invited] 光イメージングで迫る腫瘍低酸素がん細胞の動態とがん再発への寄与 [Invited] 第23回 日本化学会 生体機能関連化学部会サマースクール 第23回 日本化学会 生体機能関連化学部会サマースクール 日本化学会 生体機能関連化学部会 日本化学会 生体機能関連化学部会 2011/07/22 Japanese Oral presentation(keynote) Disclose to all
光イメージングとトラッキングで迫る腫瘍低酸素のダイナミクスと治療抵抗性への影響[Invited] 光イメージングとトラッキングで迫る腫瘍低酸素のダイナミクスと治療抵抗性への影響 [Invited] 第44回 日本整形外科学会 骨・軟部腫瘍学術集会 第44回 日本整形外科学会 骨・軟部腫瘍学術集会 日本整形外科学会 日本整形外科学会 2011/07/14 Japanese Symposium workshop panel(nominated) Disclose to all
HIF-1によるがんの放射線抵抗性機構の解明とその克服[Invited] HIF-1によるがんの放射線抵抗性機構の解明とその克服 [Invited] 第70回 日本医学放射線学会総会 第70回 日本医学放射線学会総会 日本医学放射線学会 日本医学放射線学会 2011/04/07 Japanese Symposium workshop panel(nominated) Disclose to all
放射線生物学的視点で迫る「腫瘍低酸素・放射線抵抗性・がん再発の時空間関係」[Invited] 放射線生物学的視点で迫る「腫瘍低酸素・放射線抵抗性・がん再発の時空間関係」 [Invited] 第13回 国際癌治療増感シンポジウム 第13回 国際癌治療増感シンポジウム 国際癌治療増感研究協会 国際癌治療増感研究協会 2011/02/11 Japanese Symposium workshop panel(nominated) Disclose to all
Tracking the dynamics of hypoxic tumor cells during tumor growth and after radiation therapy[Invited] Tracking the dynamics of hypoxic tumor cells during tumor growth and after radiation therapy [Invited] Tracking the dynamics of hypoxic tumor cells during tumor growth and after radiation therapy [Invited] The 1st International Symposium for Molecular-targeting Radiation Therapy The 1st International Symposium for Molecular-targeting Radiation Therapy The 1st International Symposium for Molecular-targeting Radiation Therapy 2011/02/03 English Symposium workshop panel(nominated) Disclose to all
Function of HIF-1 in Local Tumor Recurrence after Radiation Therapy[Invited] Function of HIF-1 in Local Tumor Recurrence after Radiation Therapy [Invited] 東北大学・加齢医学研究所セミナー 東北大学・加齢医学研究所セミナー 東北大学・加齢医学研究所 東北大学・加齢医学研究所 2010/11/19 Japanese Public discourse, seminar, tutorial, course, lecture and others Disclose to all
光イメージングで迫る放射線治療後のがん再発メカニズム[Invited] 光イメージングで迫る放射線治療後のがん再発メカニズム [Invited] 東北大学大学院 医学研究科附属 創生応用医学研究センター 酸素医学コアセンターシンポジウム 東北大学大学院 医学研究科附属 創生応用医学研究センター 酸素医学コアセンターシンポジウム 東北大学大学院 医学研究科附属 創生応用医学研究センター 酸素医学コアセンター 東北大学大学院 医学研究科附属 創生応用医学研究センター 酸素医学コアセンター 2010/11/19 Japanese Public discourse, seminar, tutorial, course, lecture and others Disclose to all
HIF-1(Hypoxia-inducible Factor 1)による細胞の低酸素応答メカニズム[Invited] HIF-1(Hypoxia-inducible Factor 1)による細胞の低酸素応答メカニズム [Invited] 東北大学・医学研究科 運動学分野セミナー 東北大学・医学研究科 運動学分野セミナー 東北大学・医学研究科 運動学講座 東北大学・医学研究科 運動学講座 2010/11/18 Japanese Public discourse, seminar, tutorial, course, lecture and others Disclose to all
放射線治療後のがん局所再発におけるHIF-1の機能[Invited] 放射線治療後のがん局所再発におけるHIF-1の機能 [Invited] 東北大学・薬学研究科セミナー 東北大学・薬学研究科セミナー 東北大学・薬学研究科 東北大学・薬学研究科 2010/11/17 Japanese Public discourse, seminar, tutorial, course, lecture and others Disclose to all
高精度放射線治療法の確立を見据えた低酸素イメージングの方向性[Invited] 高精度放射線治療法の確立を見据えた低酸素イメージングの方向性 [Invited] 第50回日本核医学会学術総会 第50回日本核医学会学術総会 日本核医学会 日本核医学会 2010/11/12 Japanese Symposium workshop panel(nominated) Disclose to all
低酸素がん細胞の腫瘍内ダイナミクスと放射線治療抵抗性[Invited] 低酸素がん細胞の腫瘍内ダイナミクスと放射線治療抵抗性 [Invited] 第69回日本癌学会学術総会 第69回日本癌学会学術総会 日本癌学会 日本癌学会 2010/09/23 Japanese Symposium workshop panel(nominated) Disclose to all
HIF-1イメージングによるがんの放射線抵抗性機構の解析[Invited] HIF-1イメージングによるがんの放射線抵抗性機構の解析 [Invited] 東京医科歯科大学・キャンサーボードミーティング 東京医科歯科大学・キャンサーボードミーティング 東京医科歯科大学・キャンサーボード 東京医科歯科大学・キャンサーボード 2010/09/16 Japanese Public discourse, seminar, tutorial, course, lecture and others Disclose to all
低酸素がん細胞の腫瘍内動態解析 ~がんの再発メカニズムの解明~[Invited] 低酸素がん細胞の腫瘍内動態解析 ~がんの再発メカニズムの解明~ [Invited] 群馬大学Clinical Oncology Research研究会 群馬大学Clinical Oncology Research研究会 群馬大学医学研究科 群馬大学医学研究科 2010/06/03 Japanese Oral presentation(keynote) Disclose to all
Tracking the Dynamics of Hypoxic Tumor Cells during Local Tumor Recurrence after Radiation Therapy[Invited] Tracking the Dynamics of Hypoxic Tumor Cells during Local Tumor Recurrence after Radiation Therapy [Invited] Tracking the Dynamics of Hypoxic Tumor Cells during Local Tumor Recurrence after Radiation Therapy [Invited] Fourth Military Medical University International Seminar Fourth Military Medical University International Seminar Fourth Military Medical University International Seminar 2010/05/24 English Symposium workshop panel(nominated) Disclose to all
光イメージングで迫る“がんの放射線抵抗性機構の解析[Invited] 光イメージングで迫る“がんの放射線抵抗性機構の解析 [Invited] 日本歯科大学セミナー 日本歯科大学セミナー 日本歯科大学 日本歯科大学 2010/04/02 Japanese Public discourse, seminar, tutorial, course, lecture and others Disclose to all
Reoxygenation, HIF-1, and Radioresistance[Invited] Reoxygenation, HIF-1, and Radioresistance [Invited] 第12回癌治療増感研究シンポジウム 第12回癌治療増感研究シンポジウム 国際癌治療増感研究協会 国際癌治療増感研究協会 2010/02/14 Japanese Symposium workshop panel(nominated) Disclose to all
光イメージングで迫る癌の放射線抵抗性機構[Invited] 光イメージングで迫る癌の放射線抵抗性機構 [Invited] 若手放射線生物学研究会 第1回新春勉強会 若手放射線生物学研究会 第1回新春勉強会 若手放射線生物学研究会 若手放射線生物学研究会 2010/01/30 Japanese Oral presentation(keynote) Disclose to all
低酸素誘導性因子-1(HIF-1)による癌の放射線耐性機構の解明とその克服[Invited] 低酸素誘導性因子-1(HIF-1)による癌の放射線耐性機構の解明とその克服 [Invited] 日本放射線影響学会 第52回大会 日本放射線影響学会 第52回大会 日本放射線影響学会 日本放射線影響学会 2009/11/13 Japanese Symposium workshop panel(nominated) Disclose to all
Peri-necrotic tumor cells cause recurrence after radiotherapy through migration to tumor blood vessels[Invited] Peri-necrotic tumor cells cause recurrence after radiotherapy through migration to tumor blood vessels [Invited] Peri-necrotic tumor cells cause recurrence after radiotherapy through migration to tumor blood vessels [Invited] International Symposium/Retreat, Kyoto University Global COE Program International Symposium/Retreat, Kyoto University Global COE Program International Symposium/Retreat, Kyoto University Global COE Program 2009/11/07 English Oral presentation(invited, special) Disclose to all
Optical Imaging of Tumor Hypoxia, Cell Cycle, pH, and DNA double strand breaks to Analyze the Molecular Mechanism Underlying Tumor Radioresistance[Invited] Optical Imaging of Tumor Hypoxia, Cell Cycle, pH, and DNA double strand breaks to Analyze the Molecular Mechanism Underlying Tumor Radioresistance [Invited] Optical Imaging of Tumor Hypoxia, Cell Cycle, pH, and DNA double strand breaks to Analyze the Molecular Mechanism Underlying Tumor Radioresistance [Invited] The 3rd International Symposium on Nanomedicine The 3rd International Symposium on Nanomedicine The 3rd International Symposium on Nanomedicine 2009/11/04 English Symposium workshop panel(nominated) Disclose to all
In vivo光イメージングによる“がんの放射線抵抗性機構”へのアプローチ[Invited] In vivo光イメージングによる“がんの放射線抵抗性機構”へのアプローチ [Invited] 徳島大学大学院ソシオテクノサイエンス研究部セミナー 徳島大学大学院ソシオテクノサイエンス研究部セミナー 徳島大学大学院ソシオテクノサイエンス研究部 徳島大学大学院ソシオテクノサイエンス研究部 2009/10/29 Japanese Public discourse, seminar, tutorial, course, lecture and others Disclose to all
A Molecular Mechanism Underlying HIF-1-mediated Tumor Radioresistance[Invited] A Molecular Mechanism Underlying HIF-1-mediated Tumor Radioresistance [Invited] A Molecular Mechanism Underlying HIF-1-mediated Tumor Radioresistance [Invited] 第68回日本癌学会学術総会 第68回日本癌学会学術総会 第68回日本癌学会学術総会 2009/10/03 English Symposium workshop panel(nominated) Disclose to all
HIF-1の活性化を介した癌の巧妙な放射線耐性機構 ~in vivo光イメージングによるアプローチ~[Invited] HIF-1の活性化を介した癌の巧妙な放射線耐性機構 ~in vivo光イメージングによるアプローチ~ [Invited] 第41回日本臨床分子形態学会学術総会 第41回日本臨床分子形態学会学術総会 日本臨床分子形態学会 日本臨床分子形態学会 2009/09/05 Japanese Symposium workshop panel(nominated) Disclose to all
がんの放射線耐性機構の解明と放射線治療への展開 -HIF-1活性のイメージング研究に基づく提言-[Invited] がんの放射線耐性機構の解明と放射線治療への展開 -HIF-1活性のイメージング研究に基づく提言- [Invited] 第39回 放射線による制癌シンポジウム 第39回 放射線による制癌シンポジウム 日本医学放射線学会・生物部会 日本医学放射線学会・生物部会 2009/07/11 Japanese Symposium workshop panel(nominated) Disclose to all
Tumor Hypoxia: A Microenvironmental Target in Cancer Therapy[Invited] Tumor Hypoxia: A Microenvironmental Target in Cancer Therapy [Invited] Tumor Hypoxia: A Microenvironmental Target in Cancer Therapy [Invited] The 2nd Asian Congress for Radiation Research The 2nd Asian Congress for Radiation Research The 2nd Asian Congress for Radiation Research 2009/05/20 English Symposium workshop panel(nominated) Disclose to all
Optical Imaging of Intratumoral HIF-1 Activity to Elucidate the Mechanism Underlying HIF-1-mediated Tumor Radioresistance[Invited] Optical Imaging of Intratumoral HIF-1 Activity to Elucidate the Mechanism Underlying HIF-1-mediated Tumor Radioresistance [Invited] Optical Imaging of Intratumoral HIF-1 Activity to Elucidate the Mechanism Underlying HIF-1-mediated Tumor Radioresistance [Invited] The 2nd Asian Congress for Radiation Research The 2nd Asian Congress for Radiation Research The 2nd Asian Congress for Radiation Research 2009/05/19 English Symposium workshop panel(nominated) Disclose to all
Identification of the source of Tumor recurrence after radiation therapy[Invited] Identification of the source of Tumor recurrence after radiation therapy [Invited] Identification of the source of Tumor recurrence after radiation therapy [Invited] Radiation Oncology Seminar in Seoul National University Radiation Oncology Seminar in Seoul National University Radiation Oncology Seminar in Seoul National University 2009/05/18 English Public discourse, seminar, tutorial, course, lecture and others Disclose to all
A Molecular Mechanism Underlying the HIF-1-mediated Radioresistance of Solid Tumors[Invited] A Molecular Mechanism Underlying the HIF-1-mediated Radioresistance of Solid Tumors [Invited] A Molecular Mechanism Underlying the HIF-1-mediated Radioresistance of Solid Tumors [Invited] Massachusetts General Hospital (MGH) Special Seminar Massachusetts General Hospital (MGH) Special Seminar Massachusetts General Hospital (MGH) Special Seminar 2008/09/20 English Public discourse, seminar, tutorial, course, lecture and others Disclose to all
Tumor Hypoxia and HIF-1. International Symposium for Cancer Therapy[Invited] Tumor Hypoxia and HIF-1. International Symposium for Cancer Therapy [Invited] Tumor Hypoxia and HIF-1. International Symposium for Cancer Therapy [Invited] China-Japan Bilateral Seminar on Radiation Medicine from Bench to Clinic China-Japan Bilateral Seminar on Radiation Medicine from Bench to Clinic China-Japan Bilateral Seminar on Radiation Medicine from Bench to Clinic 2007/11/20 English Symposium workshop panel(nominated) Disclose to all
低酸素応答因子(HIF-1)の活性を利用した腫瘍内低酸素領域の光イメージング[Invited] 低酸素応答因子(HIF-1)の活性を利用した腫瘍内低酸素領域の光イメージング [Invited] 第37回 放射線による制癌シンポジウム 第37回 放射線による制癌シンポジウム 日本医学放射線学会 生物部会 日本医学放射線学会 生物部会 2007/07/20 Japanese Symposium workshop panel(nominated) Disclose to all
Real-time Imaging of Tumor Hypoxia as HIF-1-dependent Bioluminescence and Fluorescence[Invited] Real-time Imaging of Tumor Hypoxia as HIF-1-dependent Bioluminescence and Fluorescence [Invited] Real-time Imaging of Tumor Hypoxia as HIF-1-dependent Bioluminescence and Fluorescence [Invited] International Symposium for Cancer Therapy International Symposium for Cancer Therapy International Symposium for Cancer Therapy 2007/03/14 English Symposium workshop panel(nominated) Disclose to all
Optical Imaging of HIF-1 activity in Tumor Xenografts[Invited] Optical Imaging of HIF-1 activity in Tumor Xenografts [Invited] Optical Imaging of HIF-1 activity in Tumor Xenografts [Invited] International Crosscutting Symposium; Molecular Bio-imaging And 4D Image-guided Radiotherapy International Crosscutting Symposium; Molecular Bio-imaging And 4D Image-guided Radiotherapy International Crosscutting Symposium; Molecular Bio-imaging And 4D Image-guided Radiotherapy 2006/07/14 English Symposium workshop panel(nominated) Disclose to all

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Title language:
Books etc
Author Author(Japanese) Author(English) Title Title(Japanese) Title(English) Publisher Publisher(Japanese) Publisher(English) Publication date Language Type Disclose
Yoshimura M, Hiraoka M, Harada H Yoshimura M, Hiraoka M, Harada H Yoshimura M, Hiraoka M, Harada H Molecularly based Chemoradiotherapy and High-Precision Radiotherapy. Tan D, Lynch H (eds). Molecularly based Chemoradiotherapy and High-Precision Radiotherapy. Tan D, Lynch H (eds). Molecularly based Chemoradiotherapy and High-Precision Radiotherapy. Tan D, Lynch H (eds). Lippincott Williams & Milkins. Lippincott Williams & Milkins. Lippincott Williams & Milkins. 2012 English Disclose to all
Harada H, Hiraoka M Harada H, Hiraoka M Harada H, Hiraoka M Protein Transduction Domain-mediated Delivery of Anti-cancer Drugs and Proteins. Lu Y and Mahato RI (eds). Pharmaceutical Perspectives of Cancer Therapeutics. Protein Transduction Domain-mediated Delivery of Anti-cancer Drugs and Proteins. Lu Y and Mahato RI (eds). Pharmaceutical Perspectives of Cancer Therapeutics. Protein Transduction Domain-mediated Delivery of Anti-cancer Drugs and Proteins. Lu Y and Mahato RI (eds). Pharmaceutical Perspectives of Cancer Therapeutics. Springer Springer Springer 2009 English Disclose to all
Harada H, Shibuya K, Hiraoka M Harada H, Shibuya K, Hiraoka M Harada H, Shibuya K, Hiraoka M Combination of Antimetabolites and Ionizing Radiation. Medical Radiology: Radiation Oncology, Multimodal Concepts for Integration of Cytotoxic Drugs. Combination of Antimetabolites and Ionizing Radiation. Medical Radiology: Radiation Oncology, Multimodal Concepts for Integration of Cytotoxic Drugs. Combination of Antimetabolites and Ionizing Radiation. Medical Radiology: Radiation Oncology, Multimodal Concepts for Integration of Cytotoxic Drugs. Springer Springer Springer 2006 English Disclose to all
Title language:
Industrial Property Rights (Patent)
Inventor(s) Inventor(s) (Japanese) Inventor(s) (English) Title Title(Japanese) Title(English) Stage Patent number Date Disclose
原田浩, 平岡真寛 原田浩, 平岡真寛 新規抗腫瘍剤及び新規抗腫瘍剤のスクリーニング方法 新規抗腫瘍剤及び新規抗腫瘍剤のスクリーニング方法 特許登録 特許6046618 2016/11/25 Disclose to all
オリエンタル酵母株式会社 オリエンタル酵母株式会社 病態の状態をリアルタイムで観察可能なモデル動物とそれを可能にする遺伝子構築物及びその使用 病態の状態をリアルタイムで観察可能なモデル動物とそれを可能にする遺伝子構築物及びその使用 特許登録 特許5093776 2012/09/28 Disclose to all
平岡真寛, 近藤科江, 原田浩 平岡真寛, 近藤科江, 原田浩 Polypeptide unstablizing protein in cells under aerobic conditions and DNA encoding the same Polypeptide unstablizing protein in cells under aerobic conditions and DNA encoding the same 特許登録 特許US 7700754 B1 2010/04/20 Disclose to all
平岡真寛, 近藤科江, 原田浩 平岡真寛, 近藤科江, 原田浩 有酸素条件下の細胞で不安定化するタンパク質をコードするDNA 有酸素条件下の細胞で不安定化するタンパク質をコードするDNA 特許登録 特許4130955 (JP) 2008/06/06 Disclose to all
平岡真寛, 近藤科江, 原田浩 平岡真寛, 近藤科江, 原田浩 Polypeptide unstabilizing protein in cells under aerobic conditions and DNA encoding the same Polypeptide unstabilizing protein in cells under aerobic conditions and DNA encoding the same 特許登録 特許200230416 (Aus) 2007/08/30 Disclose to all
Title language:
Awards
Title(Japanese) Title(English) Organization name(Japanese) Organization name(English) Date
日本放射線影響学会 優秀発表賞 Excellent Paper Award 日本放射線影響学会 JRRS 2007
日本がん分子標的治療学会 研究奨励賞 Incitement Award 日本がん分子標的治療学会 JAMTTC 2008
日本放射線影響学会 奨励賞 Incitement Award 日本放射線影響学会 JRRS 2009
Incitement Award of International Association for Cancer Treatment Incitement Award International Association for Cancer Treatment IASCT 2009
日本癌学会 奨励賞 Incitement Award 日本癌学会 JCA 2009
日本がん分子標的治療学会 第13回学術集会 特別賞 Special Award 日本がん分子標的治療学会 JAMTTC 2009
Young Scientist Award of Asian Association for Radiation Research Young Scientist Award Asian Association for Radiation Research AARR 2009
放射線影響研究奨励賞 Incitement Award 公益財団法人 放射線影響協会 JRRS 2013
日本放射線腫瘍学会 第12回優秀教育講演賞 Excellent Lecture Award 日本放射線腫瘍学会 JASTRO 2014
寺島賞 JRR Terasima Award Journal of Radiation Research, Oxford University Press Journal of Radiation Research 2018/11/08
External funds: competitive funds and Grants-in-Aid for Scientific Research (Kakenhi)
Type Position Title(Japanese) Title(English) Period
特定領域研究(がん治療) Assignment 放射線治療抵抗性克服に向けた腫瘍低酸素分画の予知と新規治療戦略開発 2003-2005
特定領域研究(がん治療) Assignment 腫瘍低酸素を標的とした生物学的および物理工学的新規放射線治療戦略 2005-2009
基盤研究(B) Assignment 低酸素誘導性因子-1システムによる酸素ホメオスターシス維持の分子機序の解明 2006-2008
萌芽研究 Assignment 分子標的薬と放射線の併用効果と副作用:マウス肺癌モデルを用いたメカニズムの解明 2006-2008
若手研究(B) Representative 放射線治療抵抗性に関わる腫瘍内微小環境のイメージングと時空間的解析  2007-2008
若手研究(B) Representative HIF‐1活性の光イメージングによる化学放射線療法プロトコールの最適化 2009-2010
基盤研究(C) Assignment 腫瘍内微小環境と概日リズムの相互作用による放射線抵抗性機構の解明とその克服 2014-2016
挑戦的萌芽研究 Assignment 新たなモデルマウスの創出によるがん幹細胞ニッチとしての低酸素領域の評価 2014-2015
挑戦的萌芽研究 Representative 腫瘍内低酸素がん細胞の動的平衡の時空間解析と放射線分割療法最適化への展開 2014-2015
基盤研究(B) Representative 悪性がん特異的な酸素ホメオスタシス制御機構の解明と放射線治療効果増強への展開 2014-2016
挑戦的萌芽研究 Representative 腫瘍内低酸素がん細胞の動的平衡の時空間解析と放射線分割療法最適化への展開 (平成26年度分) 2014/04/01-2015/03/31
基盤研究(B) Representative 悪性がん特異的な酸素ホメオスタシス制御機構の解明と放射線治療効果増強への展開 (平成26年度分) 2014/04/01-2015/03/31
基盤研究(B) Representative 悪性がん特異的な酸素ホメオスタシス制御機構の解明と放射線治療効果増強への展開 (平成27年度分) 2015/04/01-2016/03/31
挑戦的萌芽研究 Representative 腫瘍内低酸素がん細胞の動的平衡の時空間解析と放射線分割療法最適化への展開 (平成27年度分) 2015/04/01-2016/03/31
挑戦的萌芽研究 Representative 「がんの放射線抵抗性を担う責任遺伝子」の網羅的スクリーニング 2016/04/01-2018/03/31
新学術領域研究「宇宙に生きる」 Representative 放射線被ばくが主要臓器に及ぼす影響に迫る「遺伝子改変動物を用いた時空間解析」 2016/04/01-2018/03/31
新学術領域研究「システム癌新次元」 Representative 多段階発癌に於ける低酸素応答機構と癌抑制遺伝子のクロストークに迫るオミクス解析 2016/04/01-2016/03/31
挑戦的萌芽研究 Representative 「がんの放射線抵抗性を担う責任遺伝子」の網羅的スクリーニング (平成28年度分) 2016/04/01-2017/03/31
基盤研究(B) Representative 悪性がん特異的な酸素ホメオスタシス制御機構の解明と放射線治療効果増強への展開 (平成28年度分) 2016/04/01-2017/03/31
新学術領域研究(研究領域提案型) Representative 多段階発癌に於ける低酸素応答機構と癌抑制遺伝子のクロストークに迫るオミクス解析 (平成28年度分) 2016/04/01-2017/03/31
新学術領域研究(研究領域提案型) Representative 放射線被ばくが主要臓器に及ぼす影響に迫る「遺伝子改変動物を用いた時空間解析」 (平成28年度分) 2016/04/01-2017/03/31
基盤研究(C) Assignment がん細胞の低酸素応答と放射線抵抗性を担う新規遺伝子の探索;放射線増感を見据えて 2017/04/01-2020/03/31
基盤研究(B) Representative がん細胞における低酸素応答機構と抗酸化機構の相互作用: 放射線抵抗性の理解と克服 2017/04/01-2020/03/31
挑戦的萌芽研究 Representative 「がんの放射線抵抗性を担う責任遺伝子」の網羅的スクリーニング (平成29年度分) 2017/04/01-2018/03/31
基盤研究(B) Representative がん細胞における低酸素応答機構と抗酸化機構の相互作用: 放射線抵抗性の理解と克服 (平成29年度分) 2017/04/01-2018/03/31
新学術領域研究(研究領域提案型) Representative 多段階発癌に於ける低酸素応答機構と癌抑制遺伝子のクロストークに迫るオミクス解析 (平成29年度分) 2017/04/01-2018/03/31
新学術領域研究(研究領域提案型) Representative 放射線被ばくが主要臓器に及ぼす影響に迫る「遺伝子改変動物を用いた時空間解析」 (平成29年度分) 2017/04/01-2018/03/31
新学術領域研究(研究領域提案型) Representative 臓器間のDNA損傷耐用能の違いから迫る「宇宙放射線克服ストラテジーの基盤構築」 2018/04/01-2019/03/31
国際共同研究加速基金(国際共同研究強化(B)) Representative がん細胞の放射線抵抗性と浸潤を制御する新規遺伝子の作用機序と機能の解析 (平成30年度分) 2018/04/01-2019/03/31
基盤研究(B) Representative がん細胞における低酸素応答機構と抗酸化機構の相互作用: 放射線抵抗性の理解と克服 (平成30年度分) 2018/04/01-2019/03/31
新学術領域研究(研究領域提案型) Representative 臓器間のDNA損傷耐用能の違いから迫る「宇宙放射線克服ストラテジーの基盤構築」 (平成30年度分) 2018/04/01-2019/03/31
基盤研究(B) Representative がん細胞における低酸素応答機構と抗酸化機構の相互作用. 放射線抵抗性の理解と克服 2019/04/01-2020/03/31
基盤(C) Assignment がん細胞の低酸素応答と放射線抵抗性を担う新規遺伝子の探索; 放射線増感を見据えて 2019/04/01-2020/03/31
国際共同研究加速基金(国際共同研究強化(B)) Representative がん細胞の放射線抵抗性と浸潤を制御する新規遺伝子の作用機序と機能の解析 2019/04/01-2020/03/31
新学術領域研究(研究領域提案型) Representative 臓器間のDNA損傷耐用能の違いから迫る「宇宙放射線克服ストラテジーの基盤構築」 2019/04/01-2020/03/31
国際共同研究加速基金(国際共同研究強化(B)) Representative がん細胞の放射線抵抗性と浸潤を制御する新規遺伝子の作用機序と機能の解析 (2019年度分) 2019/04/01-2020/03/31
挑戦的研究(萌芽) Representative 腫瘍内微小環境依存的な浸潤を通じて放射線治療後のがん再発を起こす責任遺伝子の探索 (2019年度分) 2019/04/01-2020/03/31
基盤研究(B) Representative がん細胞における低酸素応答機構と抗酸化機構の相互作用: 放射線抵抗性の理解と克服 (2019年度分) 2019/04/01-2020/03/31
新学術領域研究(研究領域提案型) Representative 臓器間のDNA損傷耐用能の違いから迫る「宇宙放射線克服ストラテジーの基盤構築」 (2019年度分) 2019/04/01-2020/03/31
国際共同研究加速基金(国際共同研究強化(B)) Representative がんの放射線抵抗性と浸潤を制御する新規遺伝子の作用機序と機能の解析(2020年度分) 2020/04/01-2021/03/31
挑戦的萌芽研究 Representative 腫瘍内微小環境依存的な浸潤を通じて放射線治療後のがん再発を起こす責任遺伝子の探索(2020年度分) 2020/04/01-2021/03/31
新学術領域研究(研究領域提案型) Representative 腫瘍微小環境をドライビングフォースとする腫瘍内遺伝型不均一性の解析(2020年度分) 2020/04/01-2021/03/31
基盤研究(B) Representative 低酸素誘導性分泌蛋白質の利用による腫瘍低酸素のモニタリングと放射線治療効果の増感(2020年度分) 2020/04/01-2021/03/31

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External funds: other than those above
System Main person Title(Japanese) Title(English) Period
日中医学交流事業 平岡真寛 分子標的薬剤と革新的放射線治療を用いた新たながん治療戦略 2006-2007
JST シーズ発掘試験 原田浩 低酸素刺激に応答して蛍光を発する癌細胞を利用した創薬システムの開発 2007-2007
(独)医薬基盤研究所 保健医療分野における基礎研究推進事業 原田浩 化学放射線療法抵抗性の低酸素がん細胞を標的とする抗がん剤の開発 -抗がん剤のプロドラッグ化技術と分子イメージングによる薬効評価系を基盤に- 2009-2010
最先端・次世代研究開発支援プログラム 原田 浩 放射線治療抵抗性がん細胞の腫瘍内局在・動態の解明とイメージングプローブの開発 2010-2013
最先端・次世代研究開発支援プログラム 原田浩 放射線治療抵抗性がん細胞の腫瘍内局在・動態の解明とイメージングプローブの開発 2011/02/01-2014/03/31
京都市 京都発革新的医療技術研究開発助成事業 原田 浩 2013-2013
JSPS 二国間交流事業. 日英オープンパートナーシップ 原田浩 悪性がんの酸素恒常性維持機構と放射線治療抵抗性のクロストーク 2014/10/01-2016/03/31
MEXT 次世代がん研究シーズ戦略的育成プログラム  掛谷秀昭 転写活性化シグナルを標的とした革新的抗ガン化合物シーズの開発研究 2014/12/-2016/03/31
JST さきがけ 原田浩 pH恒常制御による動物個体の形態維持とその破綻 2014/10/01-2018/03/31
二国間交流事業共同研究・セミナー 原田 浩 悪性がんの酵素恒常性維持機構と放射線治療抵抗性のクロストーク (平成26年度分) 2014/04/01-2015/03/31
二国間交流事業共同研究・セミナー 原田 浩 悪性がんの酸素恒常性維持機構と放射線治療抵抗性のクロストーク (平成27年度分) 2015/04/01-2016/03/31
二国間交流事業. 日英オープンパートナーシップ 原田浩 がんの悪性化と放射線抵抗性に迫る「放射線腫瘍生物学と数理解析の融合研究」 2017/04/01-2019/03/31
AMED創薬基盤推進研究事業 原田浩 分子腫瘍学・構造生物学・理論化学・臨床医学の融合による「がんの悪性進展促進因子HPF4に対するドラッグデザイン研究」 2017/04/01-2018/03/31
二国間交流事業共同研究・セミナー 原田 浩 がんの悪性化と放射線抵抗性に迫る「放射線腫瘍生物学と数理解析の融合研究」 (平成29年度分) 2017/04/01-2018/03/31
二国間交流事業共同研究・セミナー 原田 浩 がんの悪性化と放射線抵抗性に迫る「放射線腫瘍生物学と数理解析の融合研究」 (平成30年度分) 2018/04/01-2019/03/31
AMED創薬支援推進事業 原田浩 p53変異型腫瘍の進展を促進する新規遺伝子に対する阻害剤の探索 2019/01/01-2019/03/31
AMED創薬基盤推進研究事業 原田浩 分子腫瘍学・構造生物学・理論化学・臨床医学の融合による「がんの悪性進展促進因子HPF4に対するドラッグデザイン研究」 2018/04/01-2019/03/31
AMED 橋渡し研究戦略的推進プログラム シーズA 原田浩 がんの悪性進展を促進する新規遺伝子ネットワークに対する阻害剤の開発(2019年度) 2019/04/01-2020/03/31
AMED創薬支援推進事業 原田浩 p53変異型腫瘍の進展を促進する新規遺伝子に対する阻害剤の探索(2019年度) 2019/04/01-2020/03/31
AMED創薬基盤推進研究事業 原田浩 分子腫瘍学・構造生物学・理論化学・臨床医学の融合による「がんの悪性進展促進因子HPF4に対するドラッグデザイン研究」(2019年度) 2019/04/01-2020/03/31
AMED創薬支援推進事業 原田浩 p53変異型腫瘍の進展を促進する新規遺伝子に対する阻害剤の探索(2020年度) 2020/04/01-2020/12/31
JSPS研究拠点形成事業(A先端拠点形成型) 原田浩 生体内の複雑系を対象とする統合放射線科学の国際研究拠点の形成(2020年度) 2020/04/01-2021/03/31

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Teaching subject(s)
Name(Japanese) Name(English) Term Department Period
基盤物理化学特論Ⅱ Advanced Basic Physical Chemistry II 前期不定 薬学研究科 2011/04-2012/03
Advanced Molecular and Cell Biology I Advanced Molecular and Cell Biology I 前期 生命科学研究科 2017/04-2018/03
Cancer Biology Cancer Biology 後期 生命科学研究科 2017/04-2018/03
特別実験及び演習 Experimental Course and Seminar 前期不定 生命科学研究科 2017/04-2018/03
特別実験及び演習 Experimental Course and Seminar 後期不定 生命科学研究科 2017/04-2018/03
高次生命科学特別演習 Advanced Experiments in Systemic Life Sciences 前期不定 生命科学研究科 2017/04-2018/03
高次生命科学特別演習 Advanced Experiments in Systemic Life Sciences 後期不定 生命科学研究科 2017/04-2018/03
Advanced Molecular and Cell Biology I Advanced Molecular and Cell Biology I 前期 生命科学研究科 2018/04-2019/03
Cancer Biology Cancer Biology 後期 生命科学研究科 2018/04-2019/03
特別実験及び演習A Experimental Course and Seminar A 前期不定 生命科学研究科 2018/04-2019/03
特別実験及び演習A Experimental Course and Seminar A 後期不定 生命科学研究科 2018/04-2019/03
特別実験及び演習B Experimental Course and Seminar B 前期不定 生命科学研究科 2018/04-2019/03
特別実験及び演習B Experimental Course and Seminar B 後期不定 生命科学研究科 2018/04-2019/03
特別実験及び演習C Experimental Course and Seminar C 前期不定 生命科学研究科 2018/04-2019/03
特別実験及び演習C Experimental Course and Seminar C 後期不定 生命科学研究科 2018/04-2019/03
特別実験及び演習D Experimental Course and Seminar D 前期不定 生命科学研究科 2018/04-2019/03
特別実験及び演習D Experimental Course and Seminar D 後期不定 生命科学研究科 2018/04-2019/03
特別実験及び演習 Experimental Course and Seminar 前期不定 生命科学研究科 2018/04-2019/03
特別実験及び演習 Experimental Course and Seminar 後期不定 生命科学研究科 2018/04-2019/03
生物物理学 Molecular Biophysics 前期 工学部 2018/04-2019/03
生物・生命科学入門 Introduction to Biology and Life Science 前期 全学共通科目 2018/04-2019/03
高次生命科学特別演習 Advanced Experiments in Systemic Life Sciences 前期不定 生命科学研究科 2018/04-2019/03
高次生命科学特別演習 Advanced Experiments in Systemic Life Sciences 後期不定 生命科学研究科 2018/04-2019/03
Advanced Molecular and Cell Biology I Advanced Molecular and Cell Biology I 前期 生命科学研究科 2019/04-2020/03
Cancer Biology Cancer Biology 後期 生命科学研究科 2019/04-2020/03
ILASセミナー ILAS Seminar 前期 全学共通科目 2019/04-2020/03
特別実験及び演習A Experimental Course and Seminar A 前期不定 生命科学研究科 2019/04-2020/03
特別実験及び演習A Experimental Course and Seminar A 後期不定 生命科学研究科 2019/04-2020/03
特別実験及び演習B Experimental Course and Seminar B 前期不定 生命科学研究科 2019/04-2020/03
特別実験及び演習B Experimental Course and Seminar B 後期不定 生命科学研究科 2019/04-2020/03
特別実験及び演習C Experimental Course and Seminar C 前期不定 生命科学研究科 2019/04-2020/03
特別実験及び演習C Experimental Course and Seminar C 後期不定 生命科学研究科 2019/04-2020/03
特別実験及び演習D Experimental Course and Seminar D 前期不定 生命科学研究科 2019/04-2020/03
特別実験及び演習D Experimental Course and Seminar D 後期不定 生命科学研究科 2019/04-2020/03
特別実験及び演習 Experimental Course and Seminar 前期不定 生命科学研究科 2019/04-2020/03
特別実験及び演習 Experimental Course and Seminar 後期不定 生命科学研究科 2019/04-2020/03
生物物理学 Molecular Biophysics 前期 工学部 2019/04-2020/03
高次生命科学特別演習 Advanced Experiments in Systemic Life Sciences 前期不定 生命科学研究科 2019/04-2020/03
高次生命科学特別演習 Advanced Experiments in Systemic Life Sciences 後期不定 生命科学研究科 2019/04-2020/03
Advanced Molecular and Cell Biology I Advanced Molecular and Cell Biology I 前期 生命科学研究科 2020/04-2021/03
Cancer Biology Cancer Biology 後期 生命科学研究科 2020/04-2021/03
ILASセミナー:ヒトは何故ガンになり、如何に立ち向かう … ILAS Seminar :Why we get cancer, and how we tackle it. 前期 全学共通科目 2020/04-2021/03
生物物理学 Molecular Biophysics 前期 工学部 2020/04-2021/03
(がん細胞生物学)特別実験及び演習A Experimental Course and Seminar 前期不定 生命科学研究科 2020/04-2021/03
(がん細胞生物学)特別実験及び演習B Experimental Course and Seminar 前期不定 生命科学研究科 2020/04-2021/03
(がん細胞生物学)特別実験及び演習C Experimental Course and Seminar 前期不定 生命科学研究科 2020/04-2021/03
(がん細胞生物学)特別実験及び演習D Experimental Course and Seminar 前期不定 生命科学研究科 2020/04-2021/03
(がん細胞生物学)特別実験及び演習A Experimental Course and Seminar 後期不定 生命科学研究科 2020/04-2021/03
(がん細胞生物学)特別実験及び演習B Experimental Course and Seminar 後期不定 生命科学研究科 2020/04-2021/03
(がん細胞生物学)特別実験及び演習C Experimental Course and Seminar 後期不定 生命科学研究科 2020/04-2021/03
(がん細胞生物学)特別実験及び演習D Experimental Course and Seminar 後期不定 生命科学研究科 2020/04-2021/03
(がん細胞生物学)高次生命科学特別演習 Advanced Experiments in Systemic Life Sciences 前期不定 生命科学研究科 2020/04-2021/03
(がん細胞生物学)高次生命科学特別演習 Advanced Experiments in Systemic Life Sciences 後期不定 生命科学研究科 2020/04-2021/03

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Participation in PhD Defense
Acquirer Title Position Date
山本 高正 Loss of SMAD4 Promotes Lung Metastasis of Colorectal Cancer by Accumulation of CCR1+ Tumor-associated Neutrophils through CCL15-CCR1 Axis(大腸癌のSMAD4欠損によりケモカインCCL15が分泌され、腫瘍周囲にCCR1陽性腫瘍関連好中球(TAN)が集積し、肺転移が促進する) Sub 2017/03/23
池田 愛 ES細胞の分化誘導時における休眠状態への遷移現象の発見とそのメカニズムの解析 Sub 2017/03/23
河鰭 憲幸 Cell Density-dependent Increase in Tyrosine-monophosphorylated ERK2 in MDCK Cells Expressing Active Ras or Raf(Ras及びRaf変異発現イヌ腎上皮細胞における、細胞密度依存性の活性型ERK2から非活性型ERK2への遷移) Sub 2017/03/23
石原 健司 Role of Ca2+ in the Stability and Function of TMEM16F and 16K(TMEM16Fと16Kの安定化と機能におけるCa2+の役割) Chief 2016/09/23
長 博之 Trametinib plus 4-methylumbelliferone exhibits antitumor effects by ERK blockade and CD44 downregulation and affects PD1 and PD-L1 in malignant pleural mesothelioma(悪性胸膜中皮腫においてトラメチニブと4-メチルウンベリフェロンは,ERKを遮断しCD44を下方制御することによって抗腫瘍効果を示し,PD1及びPD-L1の発現に影響を与える) Sub 2017/03/23
Isehaq AL Huseini Deletion of IKKβ in smooth muscle cells induces vascular calcification through β-catenin-Runx2 signaling(平滑筋におけるIKKβ欠損はβカテニン-Runx2のシグナル伝達を介して血管石灰化を促進する) Sub 2018/03/26
吉岡 正博 Distinct effects of EGFR inhibitors on epithelial- and mesenchymal-like esophageal squamous cell carcinoma cells(上皮様および間葉様食道扁平上皮癌細胞に対する、EGFR阻害剤の相異なる作用) Chief 2018/01/23
宇藤 恵 Volumetric modulated Dynamic WaveArc therapy reduces the dose to the hippocampus in patients with pituitary adenomas and craniopharyngiomas(Volumetric modulated Dynamic WaveArc法は下垂体腺腫・頭蓋咽頭腫症例における海馬線量を低減する) Chief 2018/03/26
山ノ井 康二 Suppression of ABHD2, identified through a functional genomics screen, causes anoikis resistance, chemoresistance and poor prognosis in ovarian cancer.(機能的ゲノミクススクリーンにより同定した因子ABHD2の発現低下は、卵巣癌のアノイキス抵抗性、化学療法抵抗性をもたらし、予後不良につながる) Sub 2017/09/25
後藤 俊彦 Liver specific Prox1 inactivation causes hepatic injury and glucose intolerance in mice(マウス肝臓特異的Prox1不活化は肝障害と耐糖能異常を引き起こす) Chief 2017/05/23
橋本 恭一 Cellular context-dependent consequences of Apc mutations on gene regulation and cellular behavior(Apc変異による遺伝子発現や細胞動態への影響は細胞種に依存する) Sub 2018/01/23
鳥井 雅恵 Analysis of the microvascular morphology and hemodynamics of breast cancer in mice using SPring-8 synchrotron radiation microangiography(SPring-8放射光微小血管造影法を利用したマウス腫瘍微小血管形態および血流動態の検討) Chief 2018/03/26
勝川 美都子 分泌タンパク質Serpin5はTollシグナル制御を介してがん抑制性細胞競合を促進する Sub 2019/03/25
吉岡 佑弥 結核肉芽腫におけるS100A9タンパク質の発現と機能に関する研究 Sub 2019/03/25
杉山 悠真 悪性黒色腫細胞B16F10における、emodinの細胞内ATPレベルと増殖に対する効果と作用機序の解明 Sub 2019/09/24
TAN YI-HSUN Investigation of G1 Arrest Mechanisms Induced by Sanguisorba officinalis Extracts in B16F10 Cells(Sanguisorba officinalis の抽出物がB16F10細胞に誘導するG1 arrest の誘導機構の解析) Sub 2019/11/25
李 会平 Critical functions of Reck in mouse forebrain development(マウス前脳発生におけるReckの重要な役割) Sub 2019/11/25
叢 博杰 多倍体肥大化細胞による腫瘍進展メカニズムの遺伝学的解析 Sub 2020/03/23

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Participation in PhD Defenses (other than KU)
Acquirer Title University Country Position Date
Tao Zhao A novel strategy to tag matrix metalloproteinases-positive cells for in vivo imaging of invasive and metastatic activity of tumor cells. Fourth Military Medical University China Sub 2010/05/23
Awards received by supervised students
Student name Award title Giver Date
後藤容子 第18回 日本癌分子標的治療学会 学術総会 若手優秀演題賞 日本癌分子標的治療学会 2014/06/27
中島良太 第23回国際癌治療増感研究会最優秀演題賞 国際癌治療増感研究協会 2017/07/15
諏訪達也 優秀研究発表賞 日本放射線影響学会 第62回大会 2019/11/16
諏訪達也 優秀ポスター発表賞 第23回菅原・大西記念癌治療増感シンポジウム 2020/02/09
Part-time lecturer (outside KU)
Cource name(Japanese) Cource name(English) Term University Department Period
東京大学 大学院工学系研究科 2019/04/01-2019/09/18
School management (title, position)
Title Period
京都大学動物実験委員会 委員 2018/01/01-2019/04/22
放射線生物研究センター長 2019/04/01-2021/03/31
京都大学動物実験委員会 委員 2018/01/01-2018/03/31
研究連携基盤運営委員会 2020/04/01-2021/03/31
Faculty management (title, position)
Title Period
生命科学研究科国際教育委員会 委員 2017/04/01-
動物実験委員会 委員 2018/04/01-
医学図書館運営委員会 委員 2018/04/01-
京都大学白眉センター専門委員会 委員 2018/04/09-2018/09/30
京都大学白眉センター専門委員会 委員 2017/04/06-2017/09/30
附属放射線生物研究センター放射線障害防止委員会 委員 2019/04/01-
SPFマウス実験室管理委員会 委員 2019/04/01-
SPFマウス実験室運営委員会 委員 2019/04/01-
特定放射性同位元素防護委員会 委員 2019/09/01-
将来像検討委員会 委員 2019/11/01-