入江一浩

Last Update: 2019/01/23 14:38:45

Name(Kanji/Kana/Abecedarium Latinum)

入江一浩/イリエカズヒロ/Kazuhiro Irie

Primary department(Org1/Job title)

Graduate Schools Agriculture/Professor

Faculty

Org1	Job title
農学部

Contact address

Type	Address(Japanese)	Address(English)
Office	〒606-8502　京都市左京区北白川追分町	Kitashirakawa Oiwake-cho, Sakyo-ku, Kyoto 606-8502, Japan

Phone

Type	Number
Office	075-753-6281

E-mail address

E-mail address
irie ＠ kais.kyoto-u.ac.jp

Affiliated academic organization(s) (Japanese)

Organization name(Japanese)	Organization name(English)
日本農芸化学会	Japan Society for Bioscience, Biotechnology, and Agrochemistry
日本化学会	The Chemical Society of Japan
日本癌学会	Japanese Cancer Association
日本ペプチド学会	The Japanese Peptide Society
日本認知症学会	Japan Society for Dementia Research
日本ケミカルバイオロジー学会	Japan Society for Chemical Biology

Affiliated academic organization(s) (overseas)

Organization name	Country
American Chemical Society	USA

Academic degree

Field(Japanese)	Field(English)	University(Japanese)	University(English)	Method
農学修士		京都大学
農学博士		京都大学

Graduate school

University(Japanese)	University(English)	Faculty(Japanese)	Faculty(English)	Major(Japanese)	Major(English)	Degree
京都大学		大学院農学研究科修士課程食品工学専攻				修了

University

University(Japanese)	University(English)	Faculty(Japanese)	Faculty(English)	Major(s)(Japanese)	Major(s)(English)	Degree
京都大学		農学部食品工学科				卒業

Highschool

Highschool	Kana
自由学園高等科（東京都東久留米市）

Work Experience

Period	Organization(Japanese)	Organization(English)	Job title(Japanese)	Job title(English)
1984/04/01-1997/03/31	京都大学農学部食品工学科	Department of Food Science and Technology, Faculty of Agriculture, Kyoto University	助手	Instructor
1992/04/08-1993/03/25	米国スタンフォード大学化学科（Paul A. Wender教授）	Department of Chemistry, Stanford University (Professor Paul A. Wender)	客員研究員	Visiting Scholar
1998/04/01-1999/03/31	京都大学農学研究科応用生命科学専攻	Division of Applied Life Sciences, Faculty of Agriculture, Kyoto University	助手	Instructor
1999/04/01-2001/03/31	京都大学農学研究科応用生命科学専攻	Division of Applied Life Sciences, Faculty of Agriculture, Kyoto University	助教授	Associate Professor
2001/04/01-2007/06/30	京都大学農学研究科食品生物科学専攻	Division of Food Science and Biotechnology, Faculty of Agriculture, Kyoto University	助教授	Associate Professor
2007/07/01-	京都大学農学研究科食品生物科学専攻	Division of Food Science and Biotechnology, Faculty of Agriculture, Kyoto University	教授	Professor

Personal Profile

(Japanese)
1982年京都大学農学部食品工学科卒業、1984年同大学大学院農学研究科修士課程修了、同年京都大学農学部助手、1988年農学博士、1999年京都大学大学院農学研究科応用生命科学専攻助教授、2007年同大学院同研究科食品生物科学専攻教授、現在に至る．この間、1992年4月から1年間、米国スタンフォード大学化学科客員研究員（Paul A. Wender教授）趣味：化石および鉱物の収集、ランの栽培
(English)
Kazuhiro Irie received his B. Agr. (1982), M. Agr. (1984), and D. Agr. (1988) from Kyoto University. He was appointed as an instructor at the Department of Food Science and Technology in Kyoto University in 1984. In 1992, he joined the group of Professor Paul A. Wender at the Department of Chemistry in Stanford University as a visiting scholar for one year. Since 2007, he has been a Full Professor of the Division of Food Science and Biotechnology, Graduate School of Agriculture, Kyoto University. His research interests are in the area of organic chemistry in life science, especially, signal transduction through protein kinase C (tumor promotion) and Alzheimer's disease.

Personal website address

URL
http://www.orgchem.kais.kyoto-u.ac.jp/

ORCID ID

orcid.org/https://orcid.org/0000-0001-7109-8568

Research Topics

(Japanese)
１．プロテインキナーゼＣのＣ１ホモロジードメインの化学合成と立体構造解析２．天然発がん促進物質の構造活性相関とプロテインキナーゼＣアイソザイム選択的な薬剤の開発３．アルツハイマー病因ペプチドの凝集機構の解明と凝集阻害剤の開発４．インドール環４位への窒素原子導入酵素の触媒機構の解析と応用５．ブリオスタチンのプロテインキナーゼＣ活性化機構に基づいた新規抗がん剤の開発
(English)
1. Synthesis and structural studies of the C1 homology domains of protein kinase C 2. Structure-activity studies on tumor promoter teleocidins and development of new medicinal leads with protein kinase C isozyme selectivity 3. Chemical studies on the aggregation mechanism of amyloid β (Aβ) peptides to develop new medicinal leads that inhibit Aβ aggregation 4. Analysis and application of the enzyme that catalyzes the introduction of a nitrogen atom into the indole ring 5. Development of new anti-cancer drugs based on the activation mechanism of protein kinase C by bryostatin

Overview of your research

(Japanese)
アルツハイマー病因物質であるアミロイドβペプチド凝集体の立体構造を、核磁気ならびに電子スピン共鳴法を用いて明らかにし、その構造に基づき、本ペプチドの凝集を抑制する抗体および低分子化合物の開発を行なっている。低分子化合物としては、特に食品に含まれるポリフェノールを対象としている。　海洋動物フサコケムシに含まれるブリオスタチン１は、副作用の少ない抗がん剤であるが、十分量供給できない。そこで、合成が容易な等価体を開発し、その作用機構の解明と抗がん剤としての最適化を目指している。
(English)
Aggregation of the 42-mer amyloid β protein (Aβ42) plays a critical role in the pathogenesis of Alzheimer's disease (AD). We have reported the importance of a turn at Glu-22 and Asp-23 of Aβ42 to induce its neurotoxicity through the formation of radicals. Based on the toxic turn structure, antibodies and compounds that inhibit the aggregation and neurotoxicity of Aβ are being developed. We focus mainly on the polyphenols in Foods as anti-agrregative compounds for Aβ. Protein kinase C (PKC) isozymes are widely recognized as targets for anti-cancer therapy. However, concerns exist about their therapeutic uses since most PKC activators are potent tumor-promoters. Bryostatin 1 (bryo-1) is a unique PKC activator with little tumor-promoting activities. Bryo-1 is undergoing clinical trials for the treatment of cancer. However, its limited availability from natural sources and difficulty in the synthesis hamper further studies on its mode of action and structural optimization. Recently, we have reported that the simple and less lipophilic analogue of tumor-promoting aplysiatoxin could be a promising lead for bryo-1-like anti-cancer drugs. In order to enhance its anti-proliferative activity against cancer cells, aplog-1 is being derivatized systematically. Moreover, the target sites of aplog-1 are being examined using FLAG-tagged-Aplog-1 and the beads technology developed by professor Handa.

Fields of research (key words)

Key words(Japanese)	Key words(English)
有機化学	organic chemistry
ケミカルバイオロジー	chemical biology
天然物化学	chemistry of natural products
有機合成	organic synthesis
アルツハイマー	Alzheimer's disease
抗がん剤	anti-cancer agents

Fields of research (kaken code)

Kaken code
Biological production chemistry/biological organic chemistry
Living organism molecular science

Published Papers

Author	Author(Japanese)	Author(English)	Title	Title(Japanese)	Title(English)	Bibliography	Bibliography(Japanese)	Bibliography(English)	Publication date	Refereed paper	Language	Publishing type	Disclose
Y. Irie, M. Hanaki, K. Murakami, T. Imamoto, T. Furuta, T. Kawabata, T. Kawase, K. Hirose, Y. Monobe, K.-i. Akagi, R. C. Yanagita and K. Irie*	Y. Irie, M. Hanaki, K. Murakami, T. Imamoto, T. Furuta, T. Kawabata, T. Kawase, K. Hirose, Y. Monobe, K.-i. Akagi, R. C. Yanagita and K. Irie*	Y. Irie, M. Hanaki, K. Murakami, T. Imamoto, T. Furuta, T. Kawabata, T. Kawase, K. Hirose, Y. Monobe, K.-i. Akagi, R. C. Yanagita and K. Irie*	Synthesis and biochemical characterization of quasi-stable trimer models of full-length amyloid beta40 with a toxic conformation	Synthesis and biochemical characterization of quasi-stable trimer models of full-length amyloid beta40 with a toxic conformation	Synthesis and biochemical characterization of quasi-stable trimer models of full-length amyloid beta40 with a toxic conformation	Chem. Commun., 55, 182-185	Chem. Commun., 55, 182-185	Chem. Commun., 55, 182-185	2019	Refereed	English	Research paper(scientific journal)	Disclose to all
Y. Hanaki, Y. Shikata, M. Kikumori, N. Hotta, M. Imoto and K. Irie*	Y. Hanaki, Y. Shikata, M. Kikumori, N. Hotta, M. Imoto and K. Irie*	Y. Hanaki, Y. Shikata, M. Kikumori, N. Hotta, M. Imoto and K. Irie*	Identification of protein kinase C isozymes involved in the anti-proliferative and pro-apoptotic activities of 10-methyl-aplog-1, a simplified analog of debromoaplysiatoxin, in several cancer cell lines	Identification of protein kinase C isozymes involved in the anti-proliferative and pro-apoptotic activities of 10-methyl-aplog-1, a simplified analog of debromoaplysiatoxin, in several cancer cell lines	Identification of protein kinase C isozymes involved in the anti-proliferative and pro-apoptotic activities of 10-methyl-aplog-1, a simplified analog of debromoaplysiatoxin, in several cancer cell lines	Biochem. Biophys. Res. Commun., 495, 1, 438-445	Biochem. Biophys. Res. Commun., 495, 1, 438-445	Biochem. Biophys. Res. Commun., 495, 1, 438-445	2018	Refereed	English	Research paper(scientific journal)	Disclose to all
Y. Ashida, R. C. Yanagita*, Y. Kawanami, M. Okamura, S. Dan and K. Irie	Y. Ashida, R. C. Yanagita*, Y. Kawanami, M. Okamura, S. Dan and K. Irie	Y. Ashida, R. C. Yanagita*, Y. Kawanami, M. Okamura, S. Dan and K. Irie	Synthesis, conformation, and biological activities of a des-A-ring analog of 18-deoxy-aplog-1, a simplified analog of debromoaplysiatoxin	Synthesis, conformation, and biological activities of a des-A-ring analog of 18-deoxy-aplog-1, a simplified analog of debromoaplysiatoxin	Synthesis, conformation, and biological activities of a des-A-ring analog of 18-deoxy-aplog-1, a simplified analog of debromoaplysiatoxin	Heterocycles, in press, DOI: 10.3987/COM-18-S(F)60	Heterocycles, in press, DOI: 10.3987/COM-18-S(F)60	Heterocycles, in press, DOI: 10.3987/COM-18-S(F)60	2018	Refereed	English	Research paper(scientific journal)	Disclose to all
Y. Kageyama, A. Saito, O. Pletnikova, G. L. Rudow, Y. Irie, Y. An, K. Murakami, K. Irie, S. M. Resnick, D. R. Fowler, L. J. Martin and J. C. Troncoso*	Y. Kageyama, A. Saito, O. Pletnikova, G. L. Rudow, Y. Irie, Y. An, K. Murakami, K. Irie, S. M. Resnick, D. R. Fowler, L. J. Martin and J. C. Troncoso*	Y. Kageyama, A. Saito, O. Pletnikova, G. L. Rudow, Y. Irie, Y. An, K. Murakami, K. Irie, S. M. Resnick, D. R. Fowler, L. J. Martin and J. C. Troncoso*	Amylod beta toxic conformer has dynamic localization in the human inferior parietal cortex in absence of amyloid plaques	Amylod beta toxic conformer has dynamic localization in the human inferior parietal cortex in absence of amyloid plaques	Amylod beta toxic conformer has dynamic localization in the human inferior parietal cortex in absence of amyloid plaques	Sci. Rep., 8, 16895	Sci. Rep., 8, 16895	Sci. Rep., 8, 16895	2018	Refereed	English	Research paper(scientific journal)	Disclose to all
M. Hanaki, K. Murakami, S. Katayama, K.-i. Akagi and K. Irie*	M. Hanaki, K. Murakami, S. Katayama, K.-i. Akagi and K. Irie*	M. Hanaki, K. Murakami, S. Katayama, K.-i. Akagi and K. Irie*	Mechanistic analyses of the suppression of amyloid β42 aggregation by apomorphine	Mechanistic analyses of the suppression of amyloid β42 aggregation by apomorphine	Mechanistic analyses of the suppression of amyloid β42 aggregation by apomorphine	Bioorg. Med. Chem., 26, 8, 1538-1546	Bioorg. Med. Chem., 26, 8, 1538-1546	Bioorg. Med. Chem., 26, 8, 1538-1546	2018	Refereed	English	Research paper(scientific journal)	Disclose to all
K. Murakami, T. Yoshioka, S. Horii, M. Hanaki, S. Midorikawa, S. Taniwaki, H. Gunji, K.-i. Akagi, T. Kawase, K. Hirose and K. Irie*	K. Murakami, T. Yoshioka, S. Horii, M. Hanaki, S. Midorikawa, S. Taniwaki, H. Gunji, K.-i. Akagi, T. Kawase, K. Hirose and K. Irie*	K. Murakami, T. Yoshioka, S. Horii, M. Hanaki, S. Midorikawa, S. Taniwaki, H. Gunji, K.-i. Akagi, T. Kawase, K. Hirose and K. Irie*	Role of the carboxy groups of triterpenoids in their inhibition of the nucleation of amyloid β42 required for forming toxic oligomers	Role of the carboxy groups of triterpenoids in their inhibition of the nucleation of amyloid β42 required for forming toxic oligomers	Role of the carboxy groups of triterpenoids in their inhibition of the nucleation of amyloid β42 required for forming toxic oligomers	Chem. Commun., 54, 6272-6275	Chem. Commun., 54, 6272-6275	Chem. Commun., 54, 6272-6275	2018	Refereed	English	Research paper(scientific journal)	Disclose to all
K. Hayakawa, Y. Hanaki, H. Tokuda, R. C. Yanagita, Y. Nakagawa, M. Okamura, S. Dan and K. Irie*	K. Hayakawa, Y. Hanaki, H. Tokuda, R. C. Yanagita, Y. Nakagawa, M. Okamura, S. Dan and K. Irie*	K. Hayakawa, Y. Hanaki, H. Tokuda, R. C. Yanagita, Y. Nakagawa, M. Okamura, S. Dan and K. Irie*	Synthesis and biological activities of acetal analogs at position 3 of 10-methyl-aplog-1, a potential anti-cancer lead derived from debromoaplysiatoxin	Synthesis and biological activities of acetal analogs at position 3 of 10-methyl-aplog-1, a potential anti-cancer lead derived from debromoaplysiatoxin	Synthesis and biological activities of acetal analogs at position 3 of 10-methyl-aplog-1, a potential anti-cancer lead derived from debromoaplysiatoxin	Heterocycles, 97, 1, 478-492	Heterocycles, 97, 1, 478-492	Heterocycles, 97, 1, 478-492	2018	Refereed	English	Research paper(scientific journal)	Disclose to all
C. Akiba*, M. Nakajima, M. Miyajima, I. Ogino, Y. Motoi, K. Kawamura, S. Adachi, A. Kondo, H. Sugano, T. Tokuda, K. Irie and H. Arai	C. Akiba*, M. Nakajima, M. Miyajima, I. Ogino, Y. Motoi, K. Kawamura, S. Adachi, A. Kondo, H. Sugano, T. Tokuda, K. Irie and H. Arai	C. Akiba*, M. Nakajima, M. Miyajima, I. Ogino, Y. Motoi, K. Kawamura, S. Adachi, A. Kondo, H. Sugano, T. Tokuda, K. Irie and H. Arai	Change of amyloid-beta 1-42 toxic conformer ratio after cerebrospinal fluid diversion predicts long-term cognitive outcome in patients with idiopathic normal pressure hydrocephalus	Change of amyloid-beta 1-42 toxic conformer ratio after cerebrospinal fluid diversion predicts long-term cognitive outcome in patients with idiopathic normal pressure hydrocephalus	Change of amyloid-beta 1-42 toxic conformer ratio after cerebrospinal fluid diversion predicts long-term cognitive outcome in patients with idiopathic normal pressure hydrocephalus	J. Alzheimers Dis., 63, 3, 989-1002	J. Alzheimers Dis., 63, 3, 989-1002	J. Alzheimers Dis., 63, 3, 989-1002	2018	Refereed	English	Research paper(scientific journal)	Disclose to all
Y. Aihara, A. Kawaguchi, M. Hanaki, K. Murakami, K. Irie and H. Shigemori*	Y. Aihara, A. Kawaguchi, M. Hanaki, K. Murakami, K. Irie and H. Shigemori*	Y. Aihara, A. Kawaguchi, M. Hanaki, K. Murakami, K. Irie and H. Shigemori*	Inhibitory activity of hispidin derivatives isolated from Inonotus obliquus on amyloid β aggregation	Inhibitory activity of hispidin derivatives isolated from Inonotus obliquus on amyloid β aggregation	Inhibitory activity of hispidin derivatives isolated from Inonotus obliquus on amyloid β aggregation	Heterocycles, 94, 7, 1280-1287	Heterocycles, 94, 7, 1280-1287	Heterocycles, 94, 7, 1280-1287	2017	Refereed	English	Research paper(scientific journal)	Disclose to all
Y. Oku, K. Murakami, K. Irie, J. Hoseki and Y. Sakai*	Y. Oku, K. Murakami, K. Irie, J. Hoseki and Y. Sakai*	Y. Oku, K. Murakami, K. Irie, J. Hoseki and Y. Sakai*	Synthesized Aβ42 caused intracellular oxidative damage, leading to cell death, via lysosome rupture	Synthesized Aβ42 caused intracellular oxidative damage, leading to cell death, via lysosome rupture	Synthesized Aβ42 caused intracellular oxidative damage, leading to cell death, via lysosome rupture	Cell Struct. Funct., 42, 1, 71-79	Cell Struct. Funct., 42, 1, 71-79	Cell Struct. Funct., 42, 1, 71-79	2017	Refereed	English	Research paper(scientific journal)	Disclose to all
A. Ben Hmidene, M. Hanaki, K. Murakami, K. Irie, H. Isoda and H. Shigemori*	A. Ben Hmidene, M. Hanaki, K. Murakami, K. Irie, H. Isoda and H. Shigemori*	A. Ben Hmidene, M. Hanaki, K. Murakami, K. Irie, H. Isoda and H. Shigemori*	Inhibitory activities of antioxidant favonoids from Tamarix gallica on amyloid aggregation related to Alzheimer's and type 2 diabetes diseases	Inhibitory activities of antioxidant favonoids from Tamarix gallica on amyloid aggregation related to Alzheimer's and type 2 diabetes diseases	Inhibitory activities of antioxidant favonoids from Tamarix gallica on amyloid aggregation related to Alzheimer's and type 2 diabetes diseases	Biol. Pharm. Bull., 40, 238-241	Biol. Pharm. Bull., 40, 238-241	Biol. Pharm. Bull., 40, 238-241	2017	Refereed	English	Research paper(scientific journal)	Disclose to all
K. Kawabata*, K. Kitamura, K. Irie, S. Naruse, T. Matsuura, T. Uemae, S. Taira, H. Ohigashi, S Murakami, M. Takahashi, Y. Kaido and B. Kawakami	K. Kawabata*, K. Kitamura, K. Irie, S. Naruse, T. Matsuura, T. Uemae, S. Taira, H. Ohigashi, S Murakami, M. Takahashi, Y. Kaido and B. Kawakami	K. Kawabata*, K. Kitamura, K. Irie, S. Naruse, T. Matsuura, T. Uemae, S. Taira, H. Ohigashi, S Murakami, M. Takahashi, Y. Kaido and B. Kawakami	Triterpenoids isolated from Ziziphus jujuba enhance glucose uptake activity in skeletal muscle cells	Triterpenoids isolated from Ziziphus jujuba enhance glucose uptake activity in skeletal muscle cells	Triterpenoids isolated from Ziziphus jujuba enhance glucose uptake activity in skeletal muscle cells	J. Nutr. Sci. Vitaminol., 63, 3, 193-199	J. Nutr. Sci. Vitaminol., 63, 3, 193-199	J. Nutr. Sci. Vitaminol., 63, 3, 193-199	2017	Refereed	English	Research paper(scientific journal)	Disclose to all
Y. Hanaki, M. Kikumori, H. Tokuda, M. Okamura, S. Dan, N. Adachi, N. Saito, R. C. Yanagita and K. Irie*	Y. Hanaki, M. Kikumori, H. Tokuda, M. Okamura, S. Dan, N. Adachi, N. Saito, R. C. Yanagita and K. Irie*	Y. Hanaki, M. Kikumori, H. Tokuda, M. Okamura, S. Dan, N. Adachi, N. Saito, R. C. Yanagita and K. Irie*	Loss of the phenolic hydroxyl group and aromaticity from the side chain of anti-proliferative 10-methyl-aplog-1, a simplified analog of aplysiatoxin, enhances its tumor-promoting and proinflammatory activities	Loss of the phenolic hydroxyl group and aromaticity from the side chain of anti-proliferative 10-methyl-aplog-1, a simplified analog of aplysiatoxin, enhances its tumor-promoting and proinflammatory activities	Loss of the phenolic hydroxyl group and aromaticity from the side chain of anti-proliferative 10-methyl-aplog-1, a simplified analog of aplysiatoxin, enhances its tumor-promoting and proinflammatory activities	Molecules, 22, 631	Molecules, 22, 631	Molecules, 22, 631	2017	Refereed	English	Research paper(scientific journal)	Disclose to all
N. Izuo, C. Kasahara, K. Murakami, T. Kume, M. Maeda, K. Irie, K. Yokote and T. Shimizu*	N. Izuo, C. Kasahara, K. Murakami, T. Kume, M. Maeda, K. Irie, K. Yokote and T. Shimizu*	N. Izuo, C. Kasahara, K. Murakami, T. Kume, M. Maeda, K. Irie, K. Yokote and T. Shimizu*	A toxic conformer of Aβ42 with a turn at 22-23 is a novel therapeutic target for Alzheimer’s disease	A toxic conformer of Aβ42 with a turn at 22-23 is a novel therapeutic target for Alzheimer’s disease	A toxic conformer of Aβ42 with a turn at 22-23 is a novel therapeutic target for Alzheimer’s disease	Sci. Rep., 7, 11811	Sci. Rep., 7, 11811	Sci. Rep., 7, 11811	2017	Refereed	English	Research paper(scientific journal)	Disclose to all
Y. Irie, K. Murakami, M. Hanaki, Y. Hanaki, T. Suzuki, Y. Monobe, T. Takai, K. Akagi, T. Kawase, K. Hirose and K. Irie*	Y. Irie, K. Murakami, M. Hanaki, Y. Hanaki, T. Suzuki, Y. Monobe, T. Takai, K. Akagi, T. Kawase, K. Hirose and K. Irie*	Y. Irie, K. Murakami, M. Hanaki, Y. Hanaki, T. Suzuki, Y. Monobe, T. Takai, K. Akagi, T. Kawase, K. Hirose and K. Irie*	Synthetic models of quasi-stable amyloid β40 oligomers with significant neurotoxicity	Synthetic models of quasi-stable amyloid β40 oligomers with significant neurotoxicity	Synthetic models of quasi-stable amyloid β40 oligomers with significant neurotoxicity	ACS Chem. Neurosci., 8, 4, 807-816	ACS Chem. Neurosci., 8, 4, 807-816	ACS Chem. Neurosci., 8, 4, 807-816	2017	Refereed	English	Research paper(scientific journal)	Disclose to all
K. Murakami and K. Irie*	村上一馬，入江一浩*	K. Murakami and K. Irie*	食品・生薬成分によるアミロイドβ42の凝集抑制機構の系統的解析	食品・生薬成分によるアミロイドβ42の凝集抑制機構の系統的解析	食品・生薬成分によるアミロイドβ42の凝集抑制機構の系統的解析	日本認知症学会誌, 31, 3, 351-360	日本認知症学会誌, 31, 3, 351-360	日本認知症学会誌, 31, 3, 351-360	2017		Japanese	Research paper(scientific journal)	Disclose to all
K. Murakami, M. Tokuda, T. Suzuki, Y. Irie, M. Hanaki, N. Izuo, Y. Monobe, K.-i. Akagi, R. Ishii, H. Tatebe, T. Tokuda, M. Maeda, T. Kume, T. Shimizu and K. Irie*	K. Murakami, M. Tokuda, T. Suzuki, Y. Irie, M. Hanaki, N. Izuo, Y. Monobe, K.-i. Akagi, R. Ishii, H. Tatebe, T. Tokuda, M. Maeda, T. Kume, T. Shimizu and K. Irie*	K. Murakami, M. Tokuda, T. Suzuki, Y. Irie, M. Hanaki, N. Izuo, Y. Monobe, K.-i. Akagi, R. Ishii, H. Tatebe, T. Tokuda, M. Maeda, T. Kume, T. Shimizu and K. Irie*	Monoclonal antibody with conformational specificity for a toxic conformer of amyloid β42 and its application toward the Alzheimer’s disease diagnosis	Monoclonal antibody with conformational specificity for a toxic conformer of amyloid β42 and its application toward the Alzheimer’s disease diagnosis	Monoclonal antibody with conformational specificity for a toxic conformer of amyloid β42 and its application toward the Alzheimer’s disease diagnosis	Sci. Rep., 6, 29038	Sci. Rep., 6, 29038	Sci. Rep., 6, 29038	2016	Refereed	English	Research paper(scientific journal)	Disclose to all
Y. Ashida, R. C. Yanagita*, C. Takahashi, Y. Kawanami and K. Irie	Y. Ashida, R. C. Yanagita*, C. Takahashi, Y. Kawanami and K. Irie	Y. Ashida, R. C. Yanagita*, C. Takahashi, Y. Kawanami and K. Irie	Binding mode prediction of aplysiatoxin, a potent agonist of protein kinase C, through molecular simulation and structure-activity study on simplified analogs of the receptor-recognition domain	Binding mode prediction of aplysiatoxin, a potent agonist of protein kinase C, through molecular simulation and structure-activity study on simplified analogs of the receptor-recognition domain	Binding mode prediction of aplysiatoxin, a potent agonist of protein kinase C, through molecular simulation and structure-activity study on simplified analogs of the receptor-recognition domain	Bioorg. Med. Chem., 24, 18, 4218-4227	Bioorg. Med. Chem., 24, 18, 4218-4227	Bioorg. Med. Chem., 24, 18, 4218-4227	2016	Refereed	English	Research paper(scientific journal)	Disclose to all
E. Kidachi, M. Kurisu, Y. Miyamae, M. Hanaki, K. Murakami, K. Irie and H. Shigemori*	E. Kidachi, M. Kurisu, Y. Miyamae, M. Hanaki, K. Murakami, K. Irie and H. Shigemori*	E. Kidachi, M. Kurisu, Y. Miyamae, M. Hanaki, K. Murakami, K. Irie and H. Shigemori*	Structure-activity relationship of phenylethanoid glycosides on the inhibition of amyloid β aggregation	Structure-activity relationship of phenylethanoid glycosides on the inhibition of amyloid β aggregation	Structure-activity relationship of phenylethanoid glycosides on the inhibition of amyloid β aggregation	Heterocycles, 92, 11, 1976-1982	Heterocycles, 92, 11, 1976-1982	Heterocycles, 92, 11, 1976-1982	2016	Refereed	English	Research paper(scientific journal)	Disclose to all
Y. Igarashi, K. Ohnishi, K. Irie and A. Murakami*	Y. Igarashi, K. Ohnishi, K. Irie and A. Murakami*	Y. Igarashi, K. Ohnishi, K. Irie and A. Murakami*	Possible contribution of zerumbone-Induced proteo-stress to its anti-inflammatory functions via the activation of heat shock factor 1	Possible contribution of zerumbone-Induced proteo-stress to its anti-inflammatory functions via the activation of heat shock factor 1	Possible contribution of zerumbone-Induced proteo-stress to its anti-inflammatory functions via the activation of heat shock factor 1	PLos One, 11, 8, e0161282	PLos One, 11, 8, e0161282	PLos One, 11, 8, e0161282	2016	Refereed	English	Research paper(scientific journal)	Disclose to all
T. Yoshioka, K. Murakami, K. Ido, M. Hanaki, K. Yamaguchi, S. Midorikawa, S. Taniwaki, H. Gunji and K. Irie*	T. Yoshioka, K. Murakami, K. Ido, M. Hanaki, K. Yamaguchi, S. Midorikawa, S. Taniwaki, H. Gunji and K. Irie*	T. Yoshioka, K. Murakami, K. Ido, M. Hanaki, K. Yamaguchi, S. Midorikawa, S. Taniwaki, H. Gunji and K. Irie*	Semisynthesis and structure–activity studies of Uncarinic acid C Isolated from Uncaria rhynchophylla as a specific inhibitor of the nucleation phase in amyloid β42 aggregation	Semisynthesis and structure–activity studies of Uncarinic acid C Isolated from Uncaria rhynchophylla as a specific inhibitor of the nucleation phase in amyloid β42 aggregation	Semisynthesis and structure–activity studies of Uncarinic acid C Isolated from Uncaria rhynchophylla as a specific inhibitor of the nucleation phase in amyloid β42 aggregation	J. Nat. Prod., 79, 10, 2521-2529	J. Nat. Prod., 79, 10, 2521-2529	J. Nat. Prod., 79, 10, 2521-2529	2016	Refereed	English	Research paper(scientific journal)	Disclose to all
M. Kikumori, R. C. Yanagita, H. Tokuda, K. Suenaga, H. Nagai and K. Irie*	M. Kikumori, R. C. Yanagita, H. Tokuda, K. Suenaga, H. Nagai and K. Irie*	M. Kikumori, R. C. Yanagita, H. Tokuda, K. Suenaga, H. Nagai and K. Irie*	Structural optimization of 10-methyl-aplog-1, a simplified analog of debromoaplysiatoxin, as an anticancer lead	Structural optimization of 10-methyl-aplog-1, a simplified analog of debromoaplysiatoxin, as an anticancer lead	Structural optimization of 10-methyl-aplog-1, a simplified analog of debromoaplysiatoxin, as an anticancer lead	Biosci. Biotechnol. Biochem., 80, 2, 221-231	Biosci. Biotechnol. Biochem., 80, 2, 221-231	Biosci. Biotechnol. Biochem., 80, 2, 221-231	2016	Refereed	English	Research paper(scientific journal)	Disclose to all
IRIE Kazuhiro	入江一浩	IRIE Kazuhiro	アルツハイマー病の正確な早期診断の実現に向けて	アルツハイマー病の正確な早期診断の実現に向けて	アルツハイマー病の正確な早期診断の実現に向けて	化学, 71, 11, 41-44	化学, 71, 11, 41-44	化学, 71, 11, 41-44	2016		Japanese	Research paper(scientific journal)	Disclose to all
M. Hanaki, K. Murakami, K.-i. Akagi and K. Irie*	M. Hanaki, K. Murakami, K.-i. Akagi and K. Irie*	M. Hanaki, K. Murakami, K.-i. Akagi and K. Irie*	Structural insights into mechanisms for inhibiting amyloid β42 aggregation by non-catechol-type flavonoids	Structural insights into mechanisms for inhibiting amyloid β42 aggregation by non-catechol-type flavonoids	Structural insights into mechanisms for inhibiting amyloid β42 aggregation by non-catechol-type flavonoids	Bioorg. Med. Chem., 24, 2, 313	Bioorg. Med. Chem., 24, 2, 313	Bioorg. Med. Chem., 24, 2, 313	2016	Refereed	English	Research paper(scientific journal)	Disclose to all
H. Takahashi, N. Adachi, T. Shirafuji, S. Danno, T. Ueyama, M. Vendruscolo, A. N. Shuvaev, T. Sugimoto, T. Seki, D. Hamada, K. Irie, H. Hirai, N. Sakai and N. Saito*	H. Takahashi, N. Adachi, T. Shirafuji, S. Danno, T. Ueyama, M. Vendruscolo, A. N. Shuvaev, T. Sugimoto, T. Seki, D. Hamada, K. Irie, H. Hirai, N. Sakai and N. Saito*	H. Takahashi, N. Adachi, T. Shirafuji, S. Danno, T. Ueyama, M. Vendruscolo, A. N. Shuvaev, T. Sugimoto, T. Seki, D. Hamada, K. Irie, H. Hirai, N. Sakai and N. Saito*	Identification and characterization of PKCgamma, implicated in SCA14, as an amyloidogenic protein	Identification and characterization of PKCgamma, implicated in SCA14, as an amyloidogenic protein	Identification and characterization of PKCgamma, implicated in SCA14, as an amyloidogenic protein	Human Mol. Genet., 24, 2, 525-539	Human Mol. Genet., 24, 2, 525-539	Human Mol. Genet., 24, 2, 525-539	2015	Refereed	English	Research paper(scientific journal)	Disclose to all
泉尾直孝*，村上一馬，久米利明，前田雅弘，入江一浩，清水孝彦	泉尾直孝*，村上一馬，久米利明，前田雅弘，入江一浩，清水孝彦		アルツハイマー病様神経毒性におけるアミロイドβコンホマーの役割	アルツハイマー病様神経毒性におけるアミロイドβコンホマーの役割		基礎老化研究, 39, 3, 29-34	基礎老化研究, 39, 3, 29-34	, 39, 3, 29-34	2015		Japanese	Research paper(scientific journal)	Disclose to all
A. Otera, Y. Miyamae*, K. Yoshida, K. Mejima, T. Akita, A. Kakizuka, K. Irie, S. Masuda, T. Kambe and M. Nagao	A. Otera, Y. Miyamae*, K. Yoshida, K. Mejima, T. Akita, A. Kakizuka, K. Irie, S. Masuda, T. Kambe and M. Nagao	A. Otera, Y. Miyamae*, K. Yoshida, K. Mejima, T. Akita, A. Kakizuka, K. Irie, S. Masuda, T. Kambe and M. Nagao	Identification of a new type of covalent PPARγ agonist using a ligand-linking strategy	Identification of a new type of covalent PPARγ agonist using a ligand-linking strategy	Identification of a new type of covalent PPARγ agonist using a ligand-linking strategy	ACS Chem. Biol., 10, 12, 2794-2804	ACS Chem. Biol., 10, 12, 2794-2804	ACS Chem. Biol., 10, 12, 2794-2804	2015	Refereed	English	Research paper(scientific journal)	Disclose to all
Y. Hanaki, R. C. Yanagita, T. Sugahara, M. Aida, H. Tokuda, N. Suzuki and K. Irie*	Y. Hanaki, R. C. Yanagita, T. Sugahara, M. Aida, H. Tokuda, N. Suzuki and K. Irie*	Y. Hanaki, R. C. Yanagita, T. Sugahara, M. Aida, H. Tokuda, N. Suzuki and K. Irie*	Synthesis and biological activities of the amide derivative of aplog-1, a simplified analog of aplysiatoxin with anti-proliferative and cytotoxic activities	Synthesis and biological activities of the amide derivative of aplog-1, a simplified analog of aplysiatoxin with anti-proliferative and cytotoxic activities	Synthesis and biological activities of the amide derivative of aplog-1, a simplified analog of aplysiatoxin with anti-proliferative and cytotoxic activities	Biosci. Biotechnol. Biochem., 79, 6, 888-895	Biosci. Biotechnol. Biochem., 79, 6, 888-895	Biosci. Biotechnol. Biochem., 79, 6, 888-895	2015	Refereed	English	Research paper(scientific journal)	Disclose to all
A. Hashimoto, K. Ohkura, M. Takahashi, K. Kizu, H. Narita, S. Enomoto, Y. Miyamae, S. Masuda, M. Nagao, K. Irie, H. Ohigashi, G. K. Andrews, and T. Kambe*	A. Hashimoto, K. Ohkura, M. Takahashi, K. Kizu, H. Narita, S. Enomoto, Y. Miyamae, S. Masuda, M. Nagao, K. Irie, H. Ohigashi, G. K. Andrews, and T. Kambe*	A. Hashimoto, K. Ohkura, M. Takahashi, K. Kizu, H. Narita, S. Enomoto, Y. Miyamae, S. Masuda, M. Nagao, K. Irie, H. Ohigashi, G. K. Andrews, and T. Kambe*	Soybean extracts increase cell surface ZIP4 abundance and cellular zinc levels: a potential novel strategy to enhance zinc absorption by ZIP4-targeting	Soybean extracts increase cell surface ZIP4 abundance and cellular zinc levels: a potential novel strategy to enhance zinc absorption by ZIP4-targeting	Soybean extracts increase cell surface ZIP4 abundance and cellular zinc levels: a potential novel strategy to enhance zinc absorption by ZIP4-targeting	Biochem. J., 472, 2, 183-193	Biochem. J., 472, 2, 183-193	Biochem. J., 472, 2, 183-193	2015	Refereed	English	Research paper(scientific journal)	Disclose to all
K. Murakami, T. Suzuki, M. Hanaki, Y. Monobe, K.-i. Akagi and K. Irie*	K. Murakami, T. Suzuki, M. Hanaki, Y. Monobe, K.-i. Akagi and K. Irie*	K. Murakami, T. Suzuki, M. Hanaki, Y. Monobe, K.-i. Akagi and K. Irie*	Synthesis and characterization of the amyloid β40 dimer model with a linker at position 30 adjacent to the intermolecular β-sheet region	Synthesis and characterization of the amyloid β40 dimer model with a linker at position 30 adjacent to the intermolecular β-sheet region	Synthesis and characterization of the amyloid β40 dimer model with a linker at position 30 adjacent to the intermolecular β-sheet region	Biochem. Biophys. Res. Commun., 466, 3, 463-467	Biochem. Biophys. Res. Commun., 466, 3, 463-467	Biochem. Biophys. Res. Commun., 466, 3, 463-467	2015	Refereed	English	Research paper(scientific journal)	Disclose to all
M. Kikumori, R. C. Yanagita and K. Irie*	M. Kikumori, R. C. Yanagita and K. Irie*	M. Kikumori, R. C. Yanagita and K. Irie*	Improved and large-scale synthesis of 10-methyl-aplog-1, a potential lead for an anticancer drug	Improved and large-scale synthesis of 10-methyl-aplog-1, a potential lead for an anticancer drug	Improved and large-scale synthesis of 10-methyl-aplog-1, a potential lead for an anticancer drug	Tetrahedron, 70, 52, 9776-9782	Tetrahedron, 70, 52, 9776-9782	Tetrahedron, 70, 52, 9776-9782	2014	Refereed	English	Research paper(scientific journal)	Disclose to all
W. Jiang, S. Tan, Y. Hanaki, K. Irie, H. Uchida, R. Watanabe, T. Suzuki, B. Sakamoto, M. Kamio and H. Nagai*	W. Jiang, S. Tan, Y. Hanaki, K. Irie, H. Uchida, R. Watanabe, T. Suzuki, B. Sakamoto, M. Kamio and H. Nagai*	W. Jiang, S. Tan, Y. Hanaki, K. Irie, H. Uchida, R. Watanabe, T. Suzuki, B. Sakamoto, M. Kamio and H. Nagai*	Two new lyngbyatoxin derivatives from the cyanobacterium Moorea producens	Two new lyngbyatoxin derivatives from the cyanobacterium Moorea producens	Two new lyngbyatoxin derivatives from the cyanobacterium Moorea producens	Mar. Drugs, 12, 5788-5800	Mar. Drugs, 12, 5788-5800	Mar. Drugs, 12, 5788-5800	2014	Refereed	English	Research paper(scientific journal)	Disclose to all
K. Irie* and R. C. Yanagita	K. Irie* and R. C. Yanagita	K. Irie* and R. C. Yanagita	Synthesis and biological activities of the simplified analogs of natural PKC ligands, bryostatin-1 and aplysiatoxin	Synthesis and biological activities of the simplified analogs of natural PKC ligands, bryostatin-1 and aplysiatoxin	Synthesis and biological activities of the simplified analogs of natural PKC ligands, bryostatin-1 and aplysiatoxin	Chem. Rec., 14, 2, 251-267	Chem. Rec., 14, 2, 251-267	Chem. Rec., 14, 2, 251-267	2014	Refereed	English	Research paper(scientific journal)	Disclose to all
W. Jiang, W. Zhou, H. Uchida, M. Kikumori, K. Irie, R. Watanabe, T. Suzuki, B. Sakamoto, M. Kamino and H. Nagai*	W. Jiang, W. Zhou, H. Uchida, M. Kikumori, K. Irie, R. Watanabe, T. Suzuki, B. Sakamoto, M. Kamino and H. Nagai*	W. Jiang, W. Zhou, H. Uchida, M. Kikumori, K. Irie, R. Watanabe, T. Suzuki, B. Sakamoto, M. Kamino and H. Nagai*	A new lyngbyatoxin from the Hawaiian cyanobacterium moorea producens	A new lyngbyatoxin from the Hawaiian cyanobacterium moorea producens	A new lyngbyatoxin from the Hawaiian cyanobacterium moorea producens	Mar. Drugs, 12, 5, 2748-2759	Mar. Drugs, 12, 5, 2748-2759	Mar. Drugs, 12, 5, 2748-2759	2014	Refereed	English	Research paper(scientific journal)	Disclose to all
A. Ohtera, Y. Miyamae, N. Nakai, A. Kawachi, K. Kawada, J. Han, H. Isoda, M. Neffati, T. Akita, K. Maejima, S. Masuda, T. Kambe, N. Mori, K. Irie and M. Nagao*	A. Ohtera, Y. Miyamae, N. Nakai, A. Kawachi, K. Kawada, J. Han, H. Isoda, M. Neffati, T. Akita, K. Maejima, S. Masuda, T. Kambe, N. Mori, K. Irie and M. Nagao*	A. Ohtera, Y. Miyamae, N. Nakai, A. Kawachi, K. Kawada, J. Han, H. Isoda, M. Neffati, T. Akita, K. Maejima, S. Masuda, T. Kambe, N. Mori, K. Irie and M. Nagao*	Identification of 6-octadecynoic acid from a methanol extract of Marrubium vulgare L. as a peroxisome proliferator-activated receptor gamma agonist	Identification of 6-octadecynoic acid from a methanol extract of Marrubium vulgare L. as a peroxisome proliferator-activated receptor gamma agonist	Identification of 6-octadecynoic acid from a methanol extract of Marrubium vulgare L. as a peroxisome proliferator-activated receptor gamma agonist	Biochem. Biophys. Res. Commun., 440, 2, 204-209	Biochem. Biophys. Res. Commun., 440, 2, 204-209	Biochem. Biophys. Res. Commun., 440, 2, 204-209	2013	Refereed	English	Research paper(scientific journal)	Disclose to all
K. Ohnishi, S. Ohkura, E. Nakahata, A. Ishisaka, Y. Kawai, J. Terao, T. Mori, T. Ishii, T. Nakayama, N. Kioka, S. Matsumoto, Y. Ikeda, M. Akiyama, K. Irie and A. Murakami*	K. Ohnishi, S. Ohkura, E. Nakahata, A. Ishisaka, Y. Kawai, J. Terao, T. Mori, T. Ishii, T. Nakayama, N. Kioka, S. Matsumoto, Y. Ikeda, M. Akiyama, K. Irie and A. Murakami*	K. Ohnishi, S. Ohkura, E. Nakahata, A. Ishisaka, Y. Kawai, J. Terao, T. Mori, T. Ishii, T. Nakayama, N. Kioka, S. Matsumoto, Y. Ikeda, M. Akiyama, K. Irie and A. Murakami*	Non-specific protein modifications by a phytochemical induce heat shock response for self-defense	Non-specific protein modifications by a phytochemical induce heat shock response for self-defense	Non-specific protein modifications by a phytochemical induce heat shock response for self-defense	PLos One, 8, 3, e58641	PLos One, 8, 3, e58641	PLos One, 8, 3, e58641	2013	Refereed	English	Research paper(scientific journal)	Disclose to all
K. Ohnishi, E. Nakahata, K. Irie and A. Murakami*	K. Ohnishi, E. Nakahata, K. Irie and A. Murakami*	K. Ohnishi, E. Nakahata, K. Irie and A. Murakami*	Zerumbone, an electrophilic sesquiterpene, induces cellular proteo-stress leading to activation of ubiquitin-proteasome system and autophagy	Zerumbone, an electrophilic sesquiterpene, induces cellular proteo-stress leading to activation of ubiquitin-proteasome system and autophagy	Zerumbone, an electrophilic sesquiterpene, induces cellular proteo-stress leading to activation of ubiquitin-proteasome system and autophagy	Biochem. Biophys. Res. Commun., 430, 2, 616-622	Biochem. Biophys. Res. Commun., 430, 2, 616-622	Biochem. Biophys. Res. Commun., 430, 2, 616-622	2013	Refereed	English	Research paper(scientific journal)	Disclose to all
N. Soejima, Y. Ohyagi*, N. Nakamura, E. Himeno, K. M. Iimura, N. Sakae, R. Yamasaki, T. Tabira, K. Murakami, K. Irie, N. Kinoshita, F. M. Laferla, Y. Kiyohara, T. Iwaki and J.-i. Kira	N. Soejima, Y. Ohyagi*, N. Nakamura, E. Himeno, K. M. Iimura, N. Sakae, R. Yamasaki, T. Tabira, K. Murakami, K. Irie, N. Kinoshita, F. M. Laferla, Y. Kiyohara, T. Iwaki and J.-i. Kira	N. Soejima, Y. Ohyagi*, N. Nakamura, E. Himeno, K. M. Iimura, N. Sakae, R. Yamasaki, T. Tabira, K. Murakami, K. Irie, N. Kinoshita, F. M. Laferla, Y. Kiyohara, T. Iwaki and J.-i. Kira	Intracellular accumulation of toxic turn amyloid-β is associated with endoplasmic reticulum stress in Alzheimer’s disease	Intracellular accumulation of toxic turn amyloid-β is associated with endoplasmic reticulum stress in Alzheimer’s disease	Intracellular accumulation of toxic turn amyloid-β is associated with endoplasmic reticulum stress in Alzheimer’s disease	Curr. Alzheimer Res., 10, 1, 11-20	Curr. Alzheimer Res., 10, 1, 11-20	Curr. Alzheimer Res., 10, 1, 11-20	2013	Refereed	English	Research paper(scientific journal)	Disclose to all
Y. Hanaki, M. Kikumori, S. Ueno, H. Tokuda, N. Suzuki and K. Irie*	Y. Hanaki, M. Kikumori, S. Ueno, H. Tokuda, N. Suzuki and K. Irie*	Y. Hanaki, M. Kikumori, S. Ueno, H. Tokuda, N. Suzuki and K. Irie*	Structure-activity studies at position 27 of aplog-1, a simplified analog of debromoaplysiatoxin with anti-proliferative activity	Structure-activity studies at position 27 of aplog-1, a simplified analog of debromoaplysiatoxin with anti-proliferative activity	Structure-activity studies at position 27 of aplog-1, a simplified analog of debromoaplysiatoxin with anti-proliferative activity	Tetrahedron, 69, 36, 7636-7645	Tetrahedron, 69, 36, 7636-7645	Tetrahedron, 69, 36, 7636-7645	2013	Refereed	English	Research paper(scientific journal)	Disclose to all
M. Sato, K. Murakami, M. Uno, H. Ikubo, Y. Nakagawa, S. Katayama, K.-i. Akagi and K. Irie*	M. Sato, K. Murakami, M. Uno, H. Ikubo, Y. Nakagawa, S. Katayama, K.-i. Akagi and K. Irie*	M. Sato, K. Murakami, M. Uno, H. Ikubo, Y. Nakagawa, S. Katayama, K.-i. Akagi and K. Irie*	Structure–activity relationship of (+)-taxifolin isolated from silymarin as an inhibitor of amyloid β aggregation.	Structure–activity relationship of (+)-taxifolin isolated from silymarin as an inhibitor of amyloid β aggregation.	Structure–activity relationship of (+)-taxifolin isolated from silymarin as an inhibitor of amyloid β aggregation.	Biosci. Biotechnol. Biochem., 77, 5, 1100-1103	Biosci. Biotechnol. Biochem., 77, 5, 1100-1103	Biosci. Biotechnol. Biochem., 77, 5, 1100-1103	2013	Refereed	English	Research paper(scientific journal)	Disclose to all
T. Kondo, N. Iwata, S. Yamanaka, H. Inoue et al.	T. Kondo, N. Iwata, S. Yamanaka, H. Inoue et al.	T. Kondo, N. Iwata, S. Yamanaka, H. Inoue et al.	Modeling Alzheimer's disease with iPSCs reveals stress phenotypes associated with intracellular Abeta and differential drug responsiveness	Modeling Alzheimer's disease with iPSCs reveals stress phenotypes associated with intracellular Abeta and differential drug responsiveness	Modeling Alzheimer's disease with iPSCs reveals stress phenotypes associated with intracellular Abeta and differential drug responsiveness	Cell Stem Cell, 12, 4, 487-496	Cell Stem Cell, 12, 4, 487-496	Cell Stem Cell, 12, 4, 487-496	2013	Refereed	English	Research paper(scientific journal)	Disclose to all
H. Kamachi, K. Tanaka, R. C. Yanagita, A. Murakami, K. Murakami, H. Tokuda, N. Suzuki, Y. Nakagawa and K. Irie*	H. Kamachi, K. Tanaka, R. C. Yanagita, A. Murakami, K. Murakami, H. Tokuda, N. Suzuki, Y. Nakagawa and K. Irie*	H. Kamachi, K. Tanaka, R. C. Yanagita, A. Murakami, K. Murakami, H. Tokuda, N. Suzuki, Y. Nakagawa and K. Irie*	Structure-activity studies on the side chain of a simplified analog of aplysiatoxin (aplog-1) with anti-proliferative activity	Structure-activity studies on the side chain of a simplified analog of aplysiatoxin (aplog-1) with anti-proliferative activity	Structure-activity studies on the side chain of a simplified analog of aplysiatoxin (aplog-1) with anti-proliferative activity	Bioorg. Med. Chem., 21, 10, 2695-2702	Bioorg. Med. Chem., 21, 10, 2695-2702	Bioorg. Med. Chem., 21, 10, 2695-2702	2013	Refereed	English	Research paper(scientific journal)	Disclose to all
N. Izuo, K. Murakami, M. Sato, M. Iwasaki, Y. Izumi, T. Shimizu, A. Akaike, K. Irie* and T. Kume*	N. Izuo, K. Murakami, M. Sato, M. Iwasaki, Y. Izumi, T. Shimizu, A. Akaike, K. Irie* and T. Kume*	N. Izuo, K. Murakami, M. Sato, M. Iwasaki, Y. Izumi, T. Shimizu, A. Akaike, K. Irie* and T. Kume*	Non-toxic conformer of amyloid β may suppress amyloid β-induced toxicity in rat primary neurons: implications for a novel therapeutic strategy for Alzheimer's disease	Non-toxic conformer of amyloid β may suppress amyloid β-induced toxicity in rat primary neurons: implications for a novel therapeutic strategy for Alzheimer's disease	Non-toxic conformer of amyloid β may suppress amyloid β-induced toxicity in rat primary neurons: implications for a novel therapeutic strategy for Alzheimer's disease	Biochem. Biophys. Res. Commun., 438, 1, 1-5	Biochem. Biophys. Res. Commun., 438, 1, 1-5	Biochem. Biophys. Res. Commun., 438, 1, 1-5	2013	Refereed	English	Research paper(scientific journal)	Disclose to all
R. C. Yanagita, H. Kamachi, M. Kikumori, H. Tokuda, N. Suzuki, K. Suenaga, H. Nagai and K. Irie*	R. C. Yanagita, H. Kamachi, M. Kikumori, H. Tokuda, N. Suzuki, K. Suenaga, H. Nagai and K. Irie*	R. C. Yanagita, H. Kamachi, M. Kikumori, H. Tokuda, N. Suzuki, K. Suenaga, H. Nagai and K. Irie*	Effects of the methoxy group in the side chain of debromoaplysiatoxin on its tumor-promoting and anti-proliferative activities	Effects of the methoxy group in the side chain of debromoaplysiatoxin on its tumor-promoting and anti-proliferative activities	Effects of the methoxy group in the side chain of debromoaplysiatoxin on its tumor-promoting and anti-proliferative activities	Bioorg. Med. Chem. Lett., 23, 15, 4319-4323	Bioorg. Med. Chem. Lett., 23, 15, 4319-4323	Bioorg. Med. Chem. Lett., 23, 15, 4319-4323	2013	Refereed	English	Research paper(scientific journal)	Disclose to all
M. Sato, K. Murakami, M. Uno, Y. Nakagawa, S. Katayama, K.-i. Akagi, Y. Masuda, K. Takegoshi and K. Irie*	M. Sato, K. Murakami, M. Uno, Y. Nakagawa, S. Katayama, K.-i. Akagi, Y. Masuda, K. Takegoshi and K. Irie*	M. Sato, K. Murakami, M. Uno, Y. Nakagawa, S. Katayama, K.-i. Akagi, Y. Masuda, K. Takegoshi and K. Irie*	Site-specific inhibitory mechanism for amyloid-beta42 aggregation by catechol-type flavonoids targeting the Lys residues	Site-specific inhibitory mechanism for amyloid-beta42 aggregation by catechol-type flavonoids targeting the Lys residues	Site-specific inhibitory mechanism for amyloid-beta42 aggregation by catechol-type flavonoids targeting the Lys residues	J. Biol. Chem., 288, 32, 23212-23224	J. Biol. Chem., 288, 32, 23212-23224	J. Biol. Chem., 288, 32, 23212-23224	2013	Refereed	English	Research paper(scientific journal)	Disclose to all
H. Sekiguchi, F. Takabayashi, K. Irie and A. Murakami*	H. Sekiguchi, F. Takabayashi, K. Irie and A. Murakami*	H. Sekiguchi, F. Takabayashi, K. Irie and A. Murakami*	Auraptene attenuates gastritis via reduction of Helicobacter pylori colonization and pro-inflammatory mediator production in C57BL/6 mice	Auraptene attenuates gastritis via reduction of Helicobacter pylori colonization and pro-inflammatory mediator production in C57BL/6 mice	Auraptene attenuates gastritis via reduction of Helicobacter pylori colonization and pro-inflammatory mediator production in C57BL/6 mice	J. Med. Food, 15, 7, 658-663	J. Med. Food, 15, 7, 658-663	J. Med. Food, 15, 7, 658-663	2012	Refereed	English	Research paper(scientific journal)	Disclose to all
Y. Ikeda, R. Yamaji, K. Irie, N. Kioka and A. Murakami*	Y. Ikeda, R. Yamaji, K. Irie, N. Kioka and A. Murakami*	Y. Ikeda, R. Yamaji, K. Irie, N. Kioka and A. Murakami*	Glyceraldehyde 3-phosphate dehydrogenase regulates cyclooxygenase-2 expression by targeting mRNA stabiliy	Glyceraldehyde 3-phosphate dehydrogenase regulates cyclooxygenase-2 expression by targeting mRNA stabiliy	Glyceraldehyde 3-phosphate dehydrogenase regulates cyclooxygenase-2 expression by targeting mRNA stabiliy	Arch. Biochem. Biophys., 528, 2, 141-147	Arch. Biochem. Biophys., 528, 2, 141-147	Arch. Biochem. Biophys., 528, 2, 141-147	2012	Refereed	English	Research paper(scientific journal)	Disclose to all
F. Tsuji, A. Ishihara, K. Kurata, A. Nakagawa, M. Okada, S. Kitamura, K. Kanamaru, Y. Masuda, K. Murakami, K. Irie and Y. Sakagami*	F. Tsuji, A. Ishihara, K. Kurata, A. Nakagawa, M. Okada, S. Kitamura, K. Kanamaru, Y. Masuda, K. Murakami, K. Irie and Y. Sakagami*	F. Tsuji, A. Ishihara, K. Kurata, A. Nakagawa, M. Okada, S. Kitamura, K. Kanamaru, Y. Masuda, K. Murakami, K. Irie and Y. Sakagami*	Geranyl modification on the tryptophan residue of ComXRO-E2 pheromone by a cell-free system	Geranyl modification on the tryptophan residue of ComXRO-E2 pheromone by a cell-free system	Geranyl modification on the tryptophan residue of ComXRO-E2 pheromone by a cell-free system	FEBS Lett., 586, 2, 174-179	FEBS Lett., 586, 2, 174-179	FEBS Lett., 586, 2, 174-179	2012	Refereed	English	Research paper(scientific journal)	Disclose to all
K. Irie*, M. Kikumori, H. Kamachi, K. Tanaka, A. Murakami, R. C. Yanagita, H. Tokuda, N. Suzuki, H. Nagai, K. Suenaga and Y. Nakagawa	K. Irie*, M. Kikumori, H. Kamachi, K. Tanaka, A. Murakami, R. C. Yanagita, H. Tokuda, N. Suzuki, H. Nagai, K. Suenaga and Y. Nakagawa	K. Irie*, M. Kikumori, H. Kamachi, K. Tanaka, A. Murakami, R. C. Yanagita, H. Tokuda, N. Suzuki, H. Nagai, K. Suenaga and Y. Nakagawa	Synthesis and structure-activity studies of simplified analogues of aplysiatoxin with antiproliferative activity like bryostatin-1	Synthesis and structure-activity studies of simplified analogues of aplysiatoxin with antiproliferative activity like bryostatin-1	Synthesis and structure-activity studies of simplified analogues of aplysiatoxin with antiproliferative activity like bryostatin-1	Pure Appl. Chem., 84, 6, 1341-1351	Pure Appl. Chem., 84, 6, 1341-1351	Pure Appl. Chem., 84, 6, 1341-1351	2012	Refereed	English	Research paper(scientific journal)	Disclose to all
S. Ueno, R. C. Yanagita, K. Murakami, A. Murakami, H. Tokuda, N. Suzuki, T. Fujiwara and K. Irie*	S. Ueno, R. C. Yanagita, K. Murakami, A. Murakami, H. Tokuda, N. Suzuki, T. Fujiwara and K. Irie*	S. Ueno, R. C. Yanagita, K. Murakami, A. Murakami, H. Tokuda, N. Suzuki, T. Fujiwara and K. Irie*	Identification and biological activities of bryostatins from Japanese bryozoan	Identification and biological activities of bryostatins from Japanese bryozoan	Identification and biological activities of bryostatins from Japanese bryozoan	Biosci. Biotechnol. Biochem., 76, 5, 1041-1043	Biosci. Biotechnol. Biochem., 76, 5, 1041-1043	Biosci. Biotechnol. Biochem., 76, 5, 1041-1043	2012	Refereed	English	Research paper(scientific journal)	Disclose to all
K. Murakami, N. Murata, Y. Noda, K. Irie, T. Shirasawa and T. Shimizu*	K. Murakami, N. Murata, Y. Noda, K. Irie, T. Shirasawa and T. Shimizu*	K. Murakami, N. Murata, Y. Noda, K. Irie, T. Shirasawa and T. Shimizu*	Stimulation of the amyloidogenic pathway by cytoplasmic superoxide radicals in an Alzheimer’s disease mouse model	Stimulation of the amyloidogenic pathway by cytoplasmic superoxide radicals in an Alzheimer’s disease mouse model	Stimulation of the amyloidogenic pathway by cytoplasmic superoxide radicals in an Alzheimer’s disease mouse model	Biosci. Biotechnol. Biochem., 76, 6, 1098-1103	Biosci. Biotechnol. Biochem., 76, 6, 1098-1103	Biosci. Biotechnol. Biochem., 76, 6, 1098-1103	2012	Refereed	English	Research paper(scientific journal)	Disclose to all
Y. Shu, R. C. Yanagita, H. Tokuda, N. Suzuki and K. Irie*	Y. Shu, R. C. Yanagita, H. Tokuda, N. Suzuki and K. Irie*	Y. Shu, R. C. Yanagita, H. Tokuda, N. Suzuki and K. Irie*	Synthesis of antineoplastic analogs of aplysiatoxin with various side chain structures	Synthesis of antineoplastic analogs of aplysiatoxin with various side chain structures	Synthesis of antineoplastic analogs of aplysiatoxin with various side chain structures	Heterocycles, 86, 1, 281-303	Heterocycles, 86, 1, 281-303	Heterocycles, 86, 1, 281-303	2012	Refereed	English	Research paper(scientific journal)	Disclose to all
K. Irie*, R. C. Yanagita and Y. Nakagawa	K. Irie*, R. C. Yanagita and Y. Nakagawa	K. Irie*, R. C. Yanagita and Y. Nakagawa	Challenges to the development of bryostatin-type anticancer drugs based on the activation mechanism of protein kinase Cδ	Challenges to the development of bryostatin-type anticancer drugs based on the activation mechanism of protein kinase Cδ	Challenges to the development of bryostatin-type anticancer drugs based on the activation mechanism of protein kinase Cδ	Med. Res. Rev., 32, 3, 518-535	Med. Res. Rev., 32, 3, 518-535	Med. Res. Rev., 32, 3, 518-535	2012	Refereed	English	Research paper(scientific journal)	Disclose to all
F. Tsuji*, A. Ishihara, A. Nakagawa, M. Okada, S. Kitamura, K. Kanamaru, Y. Masuda, K. Murakami, K. Irie and Y. Sakagami	F. Tsuji*, A. Ishihara, A. Nakagawa, M. Okada, S. Kitamura, K. Kanamaru, Y. Masuda, K. Murakami, K. Irie and Y. Sakagami	F. Tsuji*, A. Ishihara, A. Nakagawa, M. Okada, S. Kitamura, K. Kanamaru, Y. Masuda, K. Murakami, K. Irie and Y. Sakagami	Lack of the consensus sequence necessary for tryptophan prenylation in the ComX pheromone precursor	Lack of the consensus sequence necessary for tryptophan prenylation in the ComX pheromone precursor	Lack of the consensus sequence necessary for tryptophan prenylation in the ComX pheromone precursor	Biosci. Biotechnol. Biochem., 76, 8, 1492-1496	Biosci. Biotechnol. Biochem., 76, 8, 1492-1496	Biosci. Biotechnol. Biochem., 76, 8, 1492-1496	2012	Refereed	English	Research paper(scientific journal)	Disclose to all
M. Kikumori, R. C. Yanagita, H. Tokuda, N. Suzuki, H. Nagai, K. Suenaga and K. Irie*	M. Kikumori, R. C. Yanagita, H. Tokuda, N. Suzuki, H. Nagai, K. Suenaga and K. Irie*	M. Kikumori, R. C. Yanagita, H. Tokuda, N. Suzuki, H. Nagai, K. Suenaga and K. Irie*	Structure-activity studies on the spiroketal moiety of a simplified analog of debromoaplysiatoxin with antiproliferative activity	Structure-activity studies on the spiroketal moiety of a simplified analog of debromoaplysiatoxin with antiproliferative activity	Structure-activity studies on the spiroketal moiety of a simplified analog of debromoaplysiatoxin with antiproliferative activity	J. Med. Chem., 55, 11, 5614-5626	J. Med. Chem., 55, 11, 5614-5626	J. Med. Chem., 55, 11, 5614-5626	2012	Refereed	English	Research paper(scientific journal)	Disclose to all
N. Izuo, T. Kume, M. Sato, K. Murakami, K. Irie, Y. Izumi and A. Akaike	N. Izuo, T. Kume, M. Sato, K. Murakami, K. Irie, Y. Izumi and A. Akaike	N. Izuo, T. Kume, M. Sato, K. Murakami, K. Irie, Y. Izumi and A. Akaike	Toxicity in rat primary neurons through the cellular oxidative stress induced by the turn formation at positions 22 and 23 of Aβ42	Toxicity in rat primary neurons through the cellular oxidative stress induced by the turn formation at positions 22 and 23 of Aβ42	Toxicity in rat primary neurons through the cellular oxidative stress induced by the turn formation at positions 22 and 23 of Aβ42	ACS Chem. Neurosci., 3, 9, 674-681	ACS Chem. Neurosci., 3, 9, 674-681	ACS Chem. Neurosci., 3, 9, 674-681	2012	Refereed	English	Research paper(scientific journal)	Disclose to all
Y. Izumi, A. Matsumura, S. Wakita, K.-i. Akagi, H. Fukuda, T. Kume, K. Irie, H. Sugimoto, T. Hashimoto and A. Akaike*	Y. Izumi, A. Matsumura, S. Wakita, K.-i. Akagi, H. Fukuda, T. Kume, K. Irie, H. Sugimoto, T. Hashimoto and A. Akaike*	Y. Izumi, A. Matsumura, S. Wakita, K.-i. Akagi, H. Fukuda, T. Kume, K. Irie, H. Sugimoto, T. Hashimoto and A. Akaike*	Isolation, identification, and biological evaluation of Nrf2-ARE activator from the leaves of green perilla (Perilla frutescencs var. crispa f. viridis)	Isolation, identification, and biological evaluation of Nrf2-ARE activator from the leaves of green perilla (Perilla frutescencs var. crispa f. viridis)	Isolation, identification, and biological evaluation of Nrf2-ARE activator from the leaves of green perilla (Perilla frutescencs var. crispa f. viridis)	Free Radc. Biol. Med., 53, 4, 669-679	Free Radc. Biol. Med., 53, 4, 669-679	Free Radc. Biol. Med., 53, 4, 669-679	2012	Refereed	English	Research paper(scientific journal)	Disclose to all
Y. Miyamae, M. Kurisu, K. Murakami, J. Han, H. Isoda, K. Irie and H. Shigemori*	Y. Miyamae, M. Kurisu, K. Murakami, J. Han, H. Isoda, K. Irie and H. Shigemori*	Y. Miyamae, M. Kurisu, K. Murakami, J. Han, H. Isoda, K. Irie and H. Shigemori*	Protective effects of caffeoylquinic acids on the aggregation and neurotoxicity of the 42-residue amyloid β-protein	Protective effects of caffeoylquinic acids on the aggregation and neurotoxicity of the 42-residue amyloid β-protein	Protective effects of caffeoylquinic acids on the aggregation and neurotoxicity of the 42-residue amyloid β-protein	Bioorg. Med. Chem., 20, 19, 5844-5849	Bioorg. Med. Chem., 20, 19, 5844-5849	Bioorg. Med. Chem., 20, 19, 5844-5849	2012	Refereed	English	Research paper(scientific journal)	Disclose to all
村上一馬，佐藤瑞穂，鈴木啓之，泉尾直孝，久米利明，赤池昭紀，永田　徹，西崎知之，富山貴美，森　啓，入江一浩*	村上一馬，佐藤瑞穂，鈴木啓之，泉尾直孝，久米利明，赤池昭紀，永田　徹，西崎知之，富山貴美，森　啓，入江一浩*		アミロイドβの「毒性コンホマー」形成とGlu22位における遺伝性変異	アミロイドβの「毒性コンホマー」形成とGlu22位における遺伝性変異		Dementia Japan, 26, 3, 311-318	Dementia Japan, 26, 3, 311-318	, 26, 3, 311-318	2012		Japanese	Research paper(scientific journal)	Disclose to all
T. Doi, Y. Masuda*, K. Irie, K. Akagi, Y. Monobe, T. Imazawa and K. Takegoshi	T. Doi, Y. Masuda*, K. Irie, K. Akagi, Y. Monobe, T. Imazawa and K. Takegoshi	T. Doi, Y. Masuda*, K. Irie, K. Akagi, Y. Monobe, T. Imazawa and K. Takegoshi	Solid-state NMR analysis of the β-strand orientation of the protofibrils of amyloid β-protein	Solid-state NMR analysis of the β-strand orientation of the protofibrils of amyloid β-protein	Solid-state NMR analysis of the β-strand orientation of the protofibrils of amyloid β-protein	Biochem. Biophys. Res. Commun., 428, 4, 458-462	Biochem. Biophys. Res. Commun., 428, 4, 458-462	Biochem. Biophys. Res. Commun., 428, 4, 458-462	2012	Refereed	English	Research paper(scientific journal)	Disclose to all
L. Kulic*, J. McAfoose, T. Welt, C. Tackenberg, C. Späni, F. Wirth, V. Finder, U. Konietzko, M. Giese, A. Eckert, N. Kinoshita, T. Shimizu, K. Murakami, K. Irie, S. Rasool, C. Glabe, C. Hock and R. M. Nitsch	L. Kulic*, J. McAfoose, T. Welt, C. Tackenberg, C. Späni, F. Wirth, V. Finder, U. Konietzko, M. Giese, A. Eckert, N. Kinoshita, T. Shimizu, K. Murakami, K. Irie, S. Rasool, C. Glabe, C. Hock and R. M. Nitsch	L. Kulic*, J. McAfoose, T. Welt, C. Tackenberg, C. Späni, F. Wirth, V. Finder, U. Konietzko, M. Giese, A. Eckert, N. Kinoshita, T. Shimizu, K. Murakami, K. Irie, S. Rasool, C. Glabe, C. Hock and R. M. Nitsch	Early accumulation of intracellular fibrillar oligomers and late congophilic amyloid angiopathy in mice expressing the Osaka intra-Aβ APP mutation	Early accumulation of intracellular fibrillar oligomers and late congophilic amyloid angiopathy in mice expressing the Osaka intra-Aβ APP mutation	Early accumulation of intracellular fibrillar oligomers and late congophilic amyloid angiopathy in mice expressing the Osaka intra-Aβ APP mutation	Transl. Psychiatry, 2, e183	Transl. Psychiatry, 2, e183	Transl. Psychiatry, 2, e183	2012	Refereed	English	Research paper(scientific journal)	Disclose to all
村上一馬，入江一浩*	村上一馬，入江一浩*		Aβの毒性ターン構造を認識する抗体	Aβの毒性ターン構造を認識する抗体		神経内科, 77, 179-184	神経内科, 77, 179-184	, 77, 179-184	2012		Japanese	Research paper(scientific journal)	Disclose to all
M. Takahashi*, Y. Sugiyama, K. Kawabata, Y. Takahashi, K. Irie, A. Murakami, Y. Kubo, K. Kobayashi and H. Ohigashi	M. Takahashi*, Y. Sugiyama, K. Kawabata, Y. Takahashi, K. Irie, A. Murakami, Y. Kubo, K. Kobayashi and H. Ohigashi	M. Takahashi*, Y. Sugiyama, K. Kawabata, Y. Takahashi, K. Irie, A. Murakami, Y. Kubo, K. Kobayashi and H. Ohigashi	1,2-Di-O-α-linolenoyl-3-O-β-galactosyl-sn-glycerol as a superoxide generation inhibitor from Perilla frutescens var. crispa	1,2-Di-O-α-linolenoyl-3-O-β-galactosyl-sn-glycerol as a superoxide generation inhibitor from Perilla frutescens var. crispa	1,2-Di-O-α-linolenoyl-3-O-β-galactosyl-sn-glycerol as a superoxide generation inhibitor from Perilla frutescens var. crispa	Biosci. Biotechnol. Biochem., 75, 11, 2240-2242	Biosci. Biotechnol. Biochem., 75, 11, 2240-2242	Biosci. Biotechnol. Biochem., 75, 11, 2240-2242	2011	Refereed	English	Research paper(scientific journal)	Disclose to all
K. Murakami*, T. Shimizu and K. Irie	K. Murakami*, T. Shimizu and K. Irie	K. Murakami*, T. Shimizu and K. Irie	Formation of the 42-mer amyloid β radical and the therapeutic role of superoxide dismutase in Alzheimer's disease	Formation of the 42-mer amyloid β radical and the therapeutic role of superoxide dismutase in Alzheimer's disease	Formation of the 42-mer amyloid β radical and the therapeutic role of superoxide dismutase in Alzheimer's disease	J. Amino Acids, ID 654207	J. Amino Acids, ID 654207	J. Amino Acids, ID 654207	2011	Refereed	English	Research paper(scientific journal)	Disclose to all
Y. Nakagawa, M. Kikumori, Ryo C. Yanagita, A. Murakami, H. Tokuda, H. Nagai and K. Irie*	Y. Nakagawa, M. Kikumori, Ryo C. Yanagita, A. Murakami, H. Tokuda, H. Nagai and K. Irie*	Y. Nakagawa, M. Kikumori, Ryo C. Yanagita, A. Murakami, H. Tokuda, H. Nagai and K. Irie*	Synthesis and biological evaluation of the 12,12-dimethyl derivative of aplog-1, an anti-proliferative analog of tumor-promoting aplysiatoxin	Synthesis and biological evaluation of the 12,12-dimethyl derivative of aplog-1, an anti-proliferative analog of tumor-promoting aplysiatoxin	Synthesis and biological evaluation of the 12,12-dimethyl derivative of aplog-1, an anti-proliferative analog of tumor-promoting aplysiatoxin	Biosci. Biotechnol. Biochem., 75, 6, 1167-1173	Biosci. Biotechnol. Biochem., 75, 6, 1167-1173	Biosci. Biotechnol. Biochem., 75, 6, 1167-1173	2011	Refereed	English	Research paper(scientific journal)	Disclose to all
T. Kawamura, K. Matsubara, H. Otaka, E. Tashiro, K. Shindo, R. C. Yanagita, K. Irie and M. Imoto*	T. Kawamura, K. Matsubara, H. Otaka, E. Tashiro, K. Shindo, R. C. Yanagita, K. Irie and M. Imoto*	T. Kawamura, K. Matsubara, H. Otaka, E. Tashiro, K. Shindo, R. C. Yanagita, K. Irie and M. Imoto*	Generation of 'Unnatural Natural Product' library and identification of a small molecule inhibitor of XIAP	Generation of 'Unnatural Natural Product' library and identification of a small molecule inhibitor of XIAP	Generation of 'Unnatural Natural Product' library and identification of a small molecule inhibitor of XIAP	Bioorg. Med. Chem., 19, 14, 4377-4385	Bioorg. Med. Chem., 19, 14, 4377-4385	Bioorg. Med. Chem., 19, 14, 4377-4385	2011	Refereed	English	Research paper(scientific journal)	Disclose to all
K. Murakami, S. Yokoyama, N. Murata, Y. Ozawa, K. Irie, T. Shirasawa, and T. Shimizu*	K. Murakami, S. Yokoyama, N. Murata, Y. Ozawa, K. Irie, T. Shirasawa, and T. Shimizu*	K. Murakami, S. Yokoyama, N. Murata, Y. Ozawa, K. Irie, T. Shirasawa, and T. Shimizu*	Insulin receptor mutation results in insulin resistance and hyperinsulinemia but does not exacerbate Alzheimer's-like phenotypes in mice	Insulin receptor mutation results in insulin resistance and hyperinsulinemia but does not exacerbate Alzheimer's-like phenotypes in mice	Insulin receptor mutation results in insulin resistance and hyperinsulinemia but does not exacerbate Alzheimer's-like phenotypes in mice	Biochem. Biophys. Res. Commun., 409, 1, 34-39	Biochem. Biophys. Res. Commun., 409, 1, 34-39	Biochem. Biophys. Res. Commun., 409, 1, 34-39	2011	Refereed	English	Research paper(scientific journal)	Disclose to all
K. Murakami, S.-i. Yokoyama, N. Murata, Y. Ozawa, K. Irie, T. Shirasawa and T. Shimizu*	K. Murakami, S.-i. Yokoyama, N. Murata, Y. Ozawa, K. Irie, T. Shirasawa and T. Shimizu*	K. Murakami, S.-i. Yokoyama, N. Murata, Y. Ozawa, K. Irie, T. Shirasawa and T. Shimizu*	Vitamin C restores behavioral deficits and Aβ oligomerization without affecting plaque formation in a mouse model of Alzheimer’s disease	Vitamin C restores behavioral deficits and Aβ oligomerization without affecting plaque formation in a mouse model of Alzheimer’s disease	Vitamin C restores behavioral deficits and Aβ oligomerization without affecting plaque formation in a mouse model of Alzheimer’s disease	J. Alzheimers Dis., 26, 1, 7-18	J. Alzheimers Dis., 26, 1, 7-18	J. Alzheimers Dis., 26, 1, 7-18	2011	Refereed	English	Research paper(scientific journal)	Disclose to all
Y. Masuda*, M. Fukuchi, T. Yatagawa, M. Tada, K. Takeda, K. Irie, K.-i. Akagi, Y. Monobe, T. Imazawa and K. Takegoshi	Y. Masuda*, M. Fukuchi, T. Yatagawa, M. Tada, K. Takeda, K. Irie, K.-i. Akagi, Y. Monobe, T. Imazawa and K. Takegoshi	Y. Masuda*, M. Fukuchi, T. Yatagawa, M. Tada, K. Takeda, K. Irie, K.-i. Akagi, Y. Monobe, T. Imazawa and K. Takegoshi	Solid-state NMR analysis of interaction sites of curcumin and 42-residue amyloid β-protein fibrils	Solid-state NMR analysis of interaction sites of curcumin and 42-residue amyloid β-protein fibrils	Solid-state NMR analysis of interaction sites of curcumin and 42-residue amyloid β-protein fibrils	Bioorg. Med. Chem., 19, 20, 5967-5974	Bioorg. Med. Chem., 19, 20, 5967-5974	Bioorg. Med. Chem., 19, 20, 5967-5974	2011	Refereed	English	Research paper(scientific journal)	Disclose to all
K. Murakami, N. Murata, Y. Noda, S. Tahara, T. Kaneko, N. Kinoshita, H. Hatsuta, S. Murayama, K. J. Barnham, K. Irie, T. Shirasawa and T. Shimizu*	K. Murakami, N. Murata, Y. Noda, S. Tahara, T. Kaneko, N. Kinoshita, H. Hatsuta, S. Murayama, K. J. Barnham, K. Irie, T. Shirasawa and T. Shimizu*	K. Murakami, N. Murata, Y. Noda, S. Tahara, T. Kaneko, N. Kinoshita, H. Hatsuta, S. Murayama, K. J. Barnham, K. Irie, T. Shirasawa and T. Shimizu*	SOD1 (cupper/zinc superoxide dismutase) deficiency drives amyloid β protein oligomerization and memory loss in mouse model of Alzheimer’s disease	SOD1 (cupper/zinc superoxide dismutase) deficiency drives amyloid β protein oligomerization and memory loss in mouse model of Alzheimer’s disease	SOD1 (cupper/zinc superoxide dismutase) deficiency drives amyloid β protein oligomerization and memory loss in mouse model of Alzheimer’s disease	J. Biol. Chem., 286, 52, 44557-44568	J. Biol. Chem., 286, 52, 44557-44568	J. Biol. Chem., 286, 52, 44557-44568	2011	Refereed	English	Research paper(scientific journal)	Disclose to all
H. Sekiguchi, K. Irie and A. Murakami*	H. Sekiguchi, K. Irie and A. Murakami*	H. Sekiguchi, K. Irie and A. Murakami*	Suppression of CD74 expression and Helicobacter pylori adhesion by auraptene targeting serum starvation-activated ERK1/2 in NCI-N87 gastric carcinoma cells	Suppression of CD74 expression and Helicobacter pylori adhesion by auraptene targeting serum starvation-activated ERK1/2 in NCI-N87 gastric carcinoma cells	Suppression of CD74 expression and Helicobacter pylori adhesion by auraptene targeting serum starvation-activated ERK1/2 in NCI-N87 gastric carcinoma cells	Biosci. Biotechnol. Biochem., 74, 5, 1018-1024	Biosci. Biotechnol. Biochem., 74, 5, 1018-1024	Biosci. Biotechnol. Biochem., 74, 5, 1018-1024	2010	Refereed	English	Research paper(scientific journal)	Disclose to all
M. Yasuda, K. Irie and A. Murakami*	M. Yasuda, K. Irie and A. Murakami*	M. Yasuda, K. Irie and A. Murakami*	Inhibition by genistein of the lipopolysaccharide-induced down-regulation of programmed cell death 4 in RAW 264.7 mouse macrophages	Inhibition by genistein of the lipopolysaccharide-induced down-regulation of programmed cell death 4 in RAW 264.7 mouse macrophages	Inhibition by genistein of the lipopolysaccharide-induced down-regulation of programmed cell death 4 in RAW 264.7 mouse macrophages	Biosci. Biotechnol. Biochem., 74, 5, 1095-1097	Biosci. Biotechnol. Biochem., 74, 5, 1095-1097	Biosci. Biotechnol. Biochem., 74, 5, 1095-1097	2010	Refereed	English	Research paper(scientific journal)	Disclose to all
M. Yasuda, T. Schmid, D. Rübsamen, N. H. Colburn, K. Irie and A. Murakami*	M. Yasuda, T. Schmid, D. Rübsamen, N. H. Colburn, K. Irie and A. Murakami*	M. Yasuda, T. Schmid, D. Rübsamen, N. H. Colburn, K. Irie and A. Murakami*	Downregulation of programmed cell death 4 by inflammatory conditions contributes to the generation of the tumor promoting microenvironment	Downregulation of programmed cell death 4 by inflammatory conditions contributes to the generation of the tumor promoting microenvironment	Downregulation of programmed cell death 4 by inflammatory conditions contributes to the generation of the tumor promoting microenvironment	Mol. Carcinog., 49, 9, 837-848	Mol. Carcinog., 49, 9, 837-848	Mol. Carcinog., 49, 9, 837-848	2010	Refereed	English	Research paper(scientific journal)	Disclose to all
T. Kondo, R. Kajita, A. Miyazaki, M. Hokoyama, T. Nakamura-Miura, S. Mizuno, Y. Masuda, K. Irie, Y. Tanaka, S. Takada, T. Kakimoto* and Y. Sakagami*	T. Kondo, R. Kajita, A. Miyazaki, M. Hokoyama, T. Nakamura-Miura, S. Mizuno, Y. Masuda, K. Irie, Y. Tanaka, S. Takada, T. Kakimoto* and Y. Sakagami*	T. Kondo, R. Kajita, A. Miyazaki, M. Hokoyama, T. Nakamura-Miura, S. Mizuno, Y. Masuda, K. Irie, Y. Tanaka, S. Takada, T. Kakimoto* and Y. Sakagami*	Stomatal density is controlled by a mesophyll-derived signaling molecule	Stomatal density is controlled by a mesophyll-derived signaling molecule	Stomatal density is controlled by a mesophyll-derived signaling molecule	Plant Cell Physiol., 51, 1, 1-8	Plant Cell Physiol., 51, 1, 1-8	Plant Cell Physiol., 51, 1, 1-8	2010	Refereed	English	Research paper(scientific journal)	Disclose to all
M. U. Huynh, M. C. Elston, N. M. Hernandez, D. B. Ball, S. Kajiyama, K. Irie, W. H. Gerwick and D. J. Edwards*	M. U. Huynh, M. C. Elston, N. M. Hernandez, D. B. Ball, S. Kajiyama, K. Irie, W. H. Gerwick and D. J. Edwards*	M. U. Huynh, M. C. Elston, N. M. Hernandez, D. B. Ball, S. Kajiyama, K. Irie, W. H. Gerwick and D. J. Edwards*	Enzymatic production of (-)-indolactam V by LtxB, a cytochrome P450 monooxygenase	Enzymatic production of (-)-indolactam V by LtxB, a cytochrome P450 monooxygenase	Enzymatic production of (-)-indolactam V by LtxB, a cytochrome P450 monooxygenase	J. Nat. Prod., 73, 1, 71-74	J. Nat. Prod., 73, 1, 71-74	J. Nat. Prod., 73, 1, 71-74	2010	Refereed	English	Research paper(scientific journal)	Disclose to all
K. Murakami, Y. Horikoshi-Sakuraba, N. Murata, Y. Noda, Y. Masuda, N. Kinoshita, H. Hatsuta, S. Murayama, T. Shirasawa, T. Shimizu* and K. Irie*	K. Murakami, Y. Horikoshi-Sakuraba, N. Murata, Y. Noda, Y. Masuda, N. Kinoshita, H. Hatsuta, S. Murayama, T. Shirasawa, T. Shimizu* and K. Irie*	K. Murakami, Y. Horikoshi-Sakuraba, N. Murata, Y. Noda, Y. Masuda, N. Kinoshita, H. Hatsuta, S. Murayama, T. Shirasawa, T. Shimizu* and K. Irie*	Monoclonal antibody against the turn of the 42-residue amyloid β-protein at positions 22 and 23	Monoclonal antibody against the turn of the 42-residue amyloid β-protein at positions 22 and 23	Monoclonal antibody against the turn of the 42-residue amyloid β-protein at positions 22 and 23	ACS Chem. Neurosci., 1, 11, 747-756	ACS Chem. Neurosci., 1, 11, 747-756	ACS Chem. Neurosci., 1, 11, 747-756	2010	Refereed	English	Research paper(scientific journal)	Disclose to all
R. C. Yanagita, H. Kamachi, K. Tanaka, A. Murakami, Y. Nakagawa, H. Tokuda, H. Nagai and K. Irie*	R. C. Yanagita, H. Kamachi, K. Tanaka, A. Murakami, Y. Nakagawa, H. Tokuda, H. Nagai and K. Irie*	R. C. Yanagita, H. Kamachi, K. Tanaka, A. Murakami, Y. Nakagawa, H. Tokuda, H. Nagai and K. Irie*	Role of the phenolic hydroxyl group in the biological activities of simplified analogue of aplysiatoxin with antiproliferative activity	Role of the phenolic hydroxyl group in the biological activities of simplified analogue of aplysiatoxin with antiproliferative activity	Role of the phenolic hydroxyl group in the biological activities of simplified analogue of aplysiatoxin with antiproliferative activity	Bioorg. Med. Chem. Lett., 20, 20, 6064-6066	Bioorg. Med. Chem. Lett., 20, 20, 6064-6066	Bioorg. Med. Chem. Lett., 20, 20, 6064-6066	2010	Refereed	English	Research paper(scientific journal)	Disclose to all
N. Murata, K. Murakami, Y. Ozawa, N. Kinoshita, K. Irie, T. Shirasawa and T. Shimizu*	N. Murata, K. Murakami, Y. Ozawa, N. Kinoshita, K. Irie, T. Shirasawa and T. Shimizu*	N. Murata, K. Murakami, Y. Ozawa, N. Kinoshita, K. Irie, T. Shirasawa and T. Shimizu*	Silymarin attenuated the amyloid βplaque burden and improved behavioral abnormalities in an Alzheimer's disease mouse model	Silymarin attenuated the amyloid βplaque burden and improved behavioral abnormalities in an Alzheimer's disease mouse model	Silymarin attenuated the amyloid βplaque burden and improved behavioral abnormalities in an Alzheimer's disease mouse model	Biosci. Biotechnol. Biochem., 74, 11, 2299-2306	Biosci. Biotechnol. Biochem., 74, 11, 2299-2306	Biosci. Biotechnol. Biochem., 74, 11, 2299-2306	2010	Refereed	English	Research paper(scientific journal)	Disclose to all
T. Suzuki, K. Murakami, N. Izuo, T. Kume, A. Akaike, T. Nagata, T. Nishizaki, T. Tomiyama, H. Takuma, H. Mori and K. Irie*	T. Suzuki, K. Murakami, N. Izuo, T. Kume, A. Akaike, T. Nagata, T. Nishizaki, T. Tomiyama, H. Takuma, H. Mori and K. Irie*	T. Suzuki, K. Murakami, N. Izuo, T. Kume, A. Akaike, T. Nagata, T. Nishizaki, T. Tomiyama, H. Takuma, H. Mori and K. Irie*	E22Δ mutation in amyloid β-protein promotes β-sheet transformation, radical production, and synaptotoxicity, but not neurotoxicity	E22Δ mutation in amyloid β-protein promotes β-sheet transformation, radical production, and synaptotoxicity, but not neurotoxicity	E22Δ mutation in amyloid β-protein promotes β-sheet transformation, radical production, and synaptotoxicity, but not neurotoxicity	Int. J. Alzheimers Dis., ID 431320	Int. J. Alzheimers Dis., ID 431320	Int. J. Alzheimers Dis., ID 431320	2010	Refereed	English	Research paper(scientific journal)	Disclose to all
増田裕一*, 入江一浩	増田裕一*, 入江一浩		ポリフェノールによるアルツハイマー病予防の可能性	ポリフェノールによるアルツハイマー病予防の可能性		FFIジャーナル, 215, 1, 53-59	FFIジャーナル, 215, 1, 53-59	, 215, 1, 53-59	2010	Refereed	Japanese	Research paper(scientific journal)	Disclose to all
K. Murakami*, Y. Masuda, T. Shirasawa, T. Shimizu and K. Irie	K. Murakami*, Y. Masuda, T. Shirasawa, T. Shimizu and K. Irie	K. Murakami*, Y. Masuda, T. Shirasawa, T. Shimizu and K. Irie	The turn formation at positions 22 and 23 in the 42-mer amyloid β peptide: the emerging role in the pathogenesis of Alzheimer's disease	The turn formation at positions 22 and 23 in the 42-mer amyloid β peptide: the emerging role in the pathogenesis of Alzheimer's disease	The turn formation at positions 22 and 23 in the 42-mer amyloid β peptide: the emerging role in the pathogenesis of Alzheimer's disease	Geriat. Geront. Int., 10, Sup1, 169-179	Geriat. Geront. Int., 10, Sup1, 169-179	Geriat. Geront. Int., 10, Sup1, 169-179	2010	Refereed	English	Research paper(scientific journal)	Disclose to all
Y. Masuda, S. Uemura, R. Ohashi, A. Nakanishi, K. Takegoshi, T. Shimizu, T. Shirasawa and K. Irie*	Y. Masuda, S. Uemura, R. Ohashi, A. Nakanishi, K. Takegoshi, T. Shimizu, T. Shirasawa and K. Irie*	Y. Masuda, S. Uemura, R. Ohashi, A. Nakanishi, K. Takegoshi, T. Shimizu, T. Shirasawa and K. Irie*	Identification of physiological and toxic conformations in Abeta42 aggregates	Identification of physiological and toxic conformations in Abeta42 aggregates	Identification of physiological and toxic conformations in Abeta42 aggregates	ChemBioChem, 10, 2, 287-295	ChemBioChem, 10, 2, 287-295	ChemBioChem, 10, 2, 287-295	2009	Refereed	English	Research paper(scientific journal)	Disclose to all
Y. Nakagawa, R. C. Yanagita, N. Hamada, A. Murakami, H. Takahashi, N. Saito, H. Nagai and K. Irie*	Y. Nakagawa, R. C. Yanagita, N. Hamada, A. Murakami, H. Takahashi, N. Saito, H. Nagai and K. Irie*	Y. Nakagawa, R. C. Yanagita, N. Hamada, A. Murakami, H. Takahashi, N. Saito, H. Nagai and K. Irie*	A simple analogue of tumor-promoting aplysiatoxin is an antineoplastic agent rather than a tumor promoter: development of a synthetically accessible protein kinase C activator with bryostatin-like activity	A simple analogue of tumor-promoting aplysiatoxin is an antineoplastic agent rather than a tumor promoter: development of a synthetically accessible protein kinase C activator with bryostatin-like activity	A simple analogue of tumor-promoting aplysiatoxin is an antineoplastic agent rather than a tumor promoter: development of a synthetically accessible protein kinase C activator with bryostatin-like activity	J. Am. Chem. Soc., 131, 22, 7573-7579	J. Am. Chem. Soc., 131, 22, 7573-7579	J. Am. Chem. Soc., 131, 22, 7573-7579	2009	Refereed	English	Research paper(scientific journal)	Disclose to all
K. Ohnishi, K. Irie and A. Murakami*	K. Ohnishi, K. Irie and A. Murakami*	K. Ohnishi, K. Irie and A. Murakami*	In vitro covalent binding proteins of zerumbone, a chemopreventive food factor	In vitro covalent binding proteins of zerumbone, a chemopreventive food factorK. Ohnishi, K. Irie and A. Murakami*	In vitro covalent binding proteins of zerumbone, a chemopreventive food factor	Biosci. Biotechnol. Biochem., 73, 8, 1905-1907	Biosci. Biotechnol. Biochem., 73, 8, 1905-1907	Biosci. Biotechnol. Biochem., 73, 8, 1905-1907	2009	Refereed	English	Research paper(scientific journal)	Disclose to all
K. Murakami, M. Uno, Y. Masuda, T. Shimizu, T. Shirasawa and K. Irie*	K. Murakami, M. Uno, Y. Masuda, T. Shimizu, T. Shirasawa and K. Irie*	K. Murakami, M. Uno, Y. Masuda, T. Shimizu, T. Shirasawa and K. Irie*	Isomerization and/or racemization at Asp-23 of Abeta42 do not increase its aggregative ability and neurotoxicity in vitro	Isomerization and/or racemization at Asp-23 of Abeta42 do not increase its aggregative ability and neurotoxicity in vitro	Isomerization and/or racemization at Asp-23 of Abeta42 do not increase its aggregative ability and neurotoxicity in vitro	Biochem. Biophys. Res. Commun., 366, 3, 745-751	Biochem. Biophys. Res. Commun., 366, 3, 745-751	Biochem. Biophys. Res. Commun., 366, 3, 745-751	2008	Refereed	English	Research paper(scientific journal)	Disclose to all
R. C. Yanagita, Y. Nakagawa, N. Yamanaka, K. Kashiwagi, N. Saito and K. Irie*	R. C. Yanagita, Y. Nakagawa, N. Yamanaka, K. Kashiwagi, N. Saito and K. Irie*	R. C. Yanagita, Y. Nakagawa, N. Yamanaka, K. Kashiwagi, N. Saito and K. Irie*	Synthesis, conformational analysis, and biological evaluation of 1-hexylindolactam-V10 as a selective activator for novel protein kinase C isozymes	Synthesis, conformational analysis, and biological evaluation of 1-hexylindolactam-V10 as a selective activator for novel protein kinase C isozymes	Synthesis, conformational analysis, and biological evaluation of 1-hexylindolactam-V10 as a selective activator for novel protein kinase C isozymes	J. Med. Chem., 51, 1, 46-56	J. Med. Chem., 51, 1, 46-56	J. Med. Chem., 51, 1, 46-56	2008	Refereed	English	Research paper(scientific journal)	Disclose to all
T. Sugimoto, K. Itagaki and K. Irie*	T. Sugimoto, K. Itagaki and K. Irie*	T. Sugimoto, K. Itagaki and K. Irie*	Design and physicochemical properties of new fluorescent ligands of protein kinase C isozymes focused on CH/π interaction	Design and physicochemical properties of new fluorescent ligands of protein kinase C isozymes focused on CH/π interaction	Design and physicochemical properties of new fluorescent ligands of protein kinase C isozymes focused on CH/π interaction	Bioorg. Med. Chem., 16, 2, 650-657	Bioorg. Med. Chem., 16, 2, 650-657	Bioorg. Med. Chem., 16, 2, 650-657	2008	Refereed	English	Research paper(scientific journal)	Disclose to all
Y. Masuda, S. Uemura, A. Nakanishi, R. Ohashi, K. Takegoshi, T. Shimizu, T. Shirasawa and K. Irie*	Y. Masuda, S. Uemura, A. Nakanishi, R. Ohashi, K. Takegoshi, T. Shimizu, T. Shirasawa and K. Irie*	Y. Masuda, S. Uemura, A. Nakanishi, R. Ohashi, K. Takegoshi, T. Shimizu, T. Shirasawa and K. Irie*	Verification of the C-terminal intramolecular beta-sheet in Abeta42 aggregates using solid-state NMR: Implications for potent neurotoxicity through the formation of radicals	Verification of the C-terminal intramolecular beta-sheet in Abeta42 aggregates using solid-state NMR: Implications for potent neurotoxicity through the formation of radicals	Verification of the C-terminal intramolecular beta-sheet in Abeta42 aggregates using solid-state NMR: Implications for potent neurotoxicity through the formation of radicals	Bioorg. Med. Chem. Lett., 18, 11, 3206-3210	Bioorg. Med. Chem. Lett., 18, 11, 3206-3210	Bioorg. Med. Chem. Lett., 18, 11, 3206-3210	2008	Refereed	English	Research paper(scientific journal)	Disclose to all
Y. Masuda, A. Nakanishi, R. Ohashi, K. Takegoshi, T. Shimizu, T. Shirasawa and K. Irie*	Y. Masuda, A. Nakanishi, R. Ohashi, K. Takegoshi, T. Shimizu, T. Shirasawa and K. Irie*	Y. Masuda, A. Nakanishi, R. Ohashi, K. Takegoshi, T. Shimizu, T. Shirasawa and K. Irie*	Verification of the intermolecular parallel beta-sheet in E22K-Abeta42 aggregates by solid-state NMR using rotational resonance: implications for the supramolecular arrangement of the toxic conformer of Abeta42	Verification of the intermolecular parallel beta-sheet in E22K-Abeta42 aggregates by solid-state NMR using rotational resonance: implications for the supramolecular arrangement of the toxic conformer of Abeta42	Verification of the intermolecular parallel beta-sheet in E22K-Abeta42 aggregates by solid-state NMR using rotational resonance: implications for the supramolecular arrangement of the toxic conformer of Abeta42	Biosci. Biotechnol. Biochem., 72, 8, 2170-2175	Biosci. Biotechnol. Biochem., 72, 8, 2170-2175	Biosci. Biotechnol. Biochem., 72, 8, 2170-2175	2008	Refereed	English	Research paper(scientific journal)	Disclose to all
村上一馬*, 清水孝彦, 白澤卓二, 入江一浩	村上一馬*, 清水孝彦, 白澤卓二, 入江一浩		βアミロイドの毒性コンホメーション	βアミロイドの毒性コンホメーション		化学と生物, 46, 6, 431-434	化学と生物, 46, 6, 431-434	, 46, 6, 431-434	2008	Refereed	Japanese	Research paper(scientific journal)	Disclose to all
入江一浩*, 増田裕一	入江一浩*, 増田裕一		アミロイドβ (Aβ42) の毒性コンホメーションの提唱	アミロイドβ (Aβ42) の毒性コンホメーションの提唱		基礎老化研究, 32, 3, 25-29	基礎老化研究, 32, 3, 25-29	, 32, 3, 25-29	2008	Refereed	Japanese	Research paper(scientific journal)	Disclose to all
R. C. Yanagita, K. Torii, Y. Nakagawa and K. Irie*	R. C. Yanagita, K. Torii, Y. Nakagawa and K. Irie*	R. C. Yanagita, K. Torii, Y. Nakagawa and K. Irie*	Binding selectivity of 1- or 12-substituted indolactam derivatives for protein kinase C isozymes	Binding selectivity of 1- or 12-substituted indolactam derivatives for protein kinase C isozymes	Binding selectivity of 1- or 12-substituted indolactam derivatives for protein kinase C isozymes	Heterocycles, 73, 289-302	Heterocycles, 73, 289-302	Heterocycles, 73, 289-302	2007	Refereed	English	Research paper(scientific journal)	Disclose to all
K. Murakami, H. Hara, Y. Masuda, H. Ohigashi and K. irie*	K. Murakami, H. Hara, Y. Masuda, H. Ohigashi and K. irie*	K. Murakami, H. Hara, Y. Masuda, H. Ohigashi and K. irie*	Distance measurement between Tyr10 and Met35 in amyloid beta by site-directed spin-labeling ESR spectroscopy: implications for the stronger neurotoxicity of Abeta42 than Abeta40	Distance measurement between Tyr10 and Met35 in amyloid beta by site-directed spin-labeling ESR spectroscopy: implications for the stronger neurotoxicity of Abeta42 than Abeta40	Distance measurement between Tyr10 and Met35 in amyloid beta by site-directed spin-labeling ESR spectroscopy: implications for the stronger neurotoxicity of Abeta42 than Abeta40	ChemBioChem, 8, 18, 2308-2314	ChemBioChem, 8, 18, 2308-2314	ChemBioChem, 8, 18, 2308-2314	2007	Refereed	English	Research paper(scientific journal)	Disclose to all
K. Irie*, K. Murakami, Y. Masuda, A. Morimoto, H. Ohigashi, H. Hara, R. Ohashi, K. Takegoshi, H. Fukuda, M. Nagao, T. Shimizu and T. Shirasawa	K. Irie*, K. Murakami, Y. Masuda, A. Morimoto, H. Ohigashi, H. Hara, R. Ohashi, K. Takegoshi, H. Fukuda, M. Nagao, T. Shimizu and T. Shirasawa	K. Irie*, K. Murakami, Y. Masuda, A. Morimoto, H. Ohigashi, H. Hara, R. Ohashi, K. Takegoshi, H. Fukuda, M. Nagao, T. Shimizu and T. Shirasawa	The toxic conformation of the 42-residue amyloid β peptide and Its relevance to oxidative stress in alzheimer's disease	The toxic conformation of the 42-residue amyloid β peptide and Its relevance to oxidative stress in alzheimer's disease	The toxic conformation of the 42-residue amyloid β peptide and Its relevance to oxidative stress in alzheimer's disease	Mini-Rev. Med. Chem., 7, 10, 1001-1008	Mini-Rev. Med. Chem., 7, 10, 1001-1008	Mini-Rev. Med. Chem., 7, 10, 1001-1008	2007	Refereed	English	Research paper(scientific journal)	Disclose to all
Y. Nakagawa, K. Irie*, R. C. Yanagita, H. Ohigashi, K. Tsuda, K. Kashiwagi and N. Saito	Y. Nakagawa, K. Irie*, R. C. Yanagita, H. Ohigashi, K. Tsuda, K. Kashiwagi and N. Saito	Y. Nakagawa, K. Irie*, R. C. Yanagita, H. Ohigashi, K. Tsuda, K. Kashiwagi and N. Saito	Design and synthesis of 8-octyl-benzolactam-V9, a selective activator for protein kinase C epsilon and eta	Design and synthesis of 8-octyl-benzolactam-V9, a selective activator for protein kinase C epsilon and eta	Design and synthesis of 8-octyl-benzolactam-V9, a selective activator for protein kinase C epsilon and eta	J. Med. Chem., 49, 9, 2681-2688	J. Med. Chem., 49, 9, 2681-2688	J. Med. Chem., 49, 9, 2681-2688	2006	Refereed	English	Research paper(scientific journal)	Disclose to all
入江一浩	入江一浩		CH/π相互作用を利用した薬剤開発	CH/π相互作用を利用した薬剤開発		ファルマシア, 42, 5, 427-430	ファルマシア, 42, 5, 427-430	, 42, 5, 427-430	2006	Refereed	Japanese	Research paper(scientific journal)	Disclose to all
Y. Nakagawa, K. Irie*, R. C. Yanagita, H. Ohigashi and K. Tsuda	Y. Nakagawa, K. Irie*, R. C. Yanagita, H. Ohigashi and K. Tsuda	Y. Nakagawa, K. Irie*, R. C. Yanagita, H. Ohigashi and K. Tsuda	Indolactam-V is involved in the CH/π interaction with Pro-11 of the PKCdelta C1B domain: application for the structural optimization of the PKCdelta ligand	Indolactam-V is involved in the CH/π interaction with Pro-11 of the PKCdelta C1B domain: application for the structural optimization of the PKCdelta ligand	Indolactam-V is involved in the CH/π interaction with Pro-11 of the PKCdelta C1B domain: application for the structural optimization of the PKCdelta ligand	J. Am. Chem. Soc., 127, 16, 5746-5747	J. Am. Chem. Soc., 127, 16, 5746-5747	J. Am. Chem. Soc., 127, 16, 5746-5747	2005	Refereed	English	Research paper(scientific journal)	Disclose to all
K. Murakami, K. Irie*, H. Ohigashi, H. Hara, M. Nagao, T. Shimizu and T. Shirasawa	K. Murakami, K. Irie*, H. Ohigashi, H. Hara, M. Nagao, T. Shimizu and T. Shirasawa	K. Murakami, K. Irie*, H. Ohigashi, H. Hara, M. Nagao, T. Shimizu and T. Shirasawa	Formation and stabilization model of the 42-mer Abeta radical: implications for the long-lasting oxidative stress in Alzheimer's disease	Formation and stabilization model of the 42-mer Abeta radical: implications for the long-lasting oxidative stress in Alzheimer's disease	Formation and stabilization model of the 42-mer Abeta radical: implications for the long-lasting oxidative stress in Alzheimer's disease	J. Am. Chem. Soc., 127, 43, 15168-15174	J. Am. Chem. Soc., 127, 43, 15168-15174	J. Am. Chem. Soc., 127, 43, 15168-15174	2005	Refereed	English	Research paper(scientific journal)	Disclose to all
M. Nagao*, T.-C. Wen, M. Okamoto, K. Irie, T. Takaku and M. Sakanaka	M. Nagao*, T.-C. Wen, M. Okamoto, K. Irie, T. Takaku and M. Sakanaka	M. Nagao*, T.-C. Wen, M. Okamoto, K. Irie, T. Takaku and M. Sakanaka	In vivo neuroprotective activity of epopeptide AB against ischemic damage	In vivo neuroprotective activity of epopeptide AB against ischemic damage	In vivo neuroprotective activity of epopeptide AB against ischemic damage	Cytotechnol., 47, 1/3, 139-144	Cytotechnol., 47, 1/3, 139-144	Cytotechnol., 47, 1/3, 139-144	2005	Refereed	English	Research paper(scientific journal)	Disclose to all
Y. Masuda, K. Irie*, K. Murakami, H. Ohigashi, R. Ohashi, K. Takegoshi, T. Shimizu and T. Shirasawa	Y. Masuda, K. Irie*, K. Murakami, H. Ohigashi, R. Ohashi, K. Takegoshi, T. Shimizu and T. Shirasawa	Y. Masuda, K. Irie*, K. Murakami, H. Ohigashi, R. Ohashi, K. Takegoshi, T. Shimizu and T. Shirasawa	Verification of the turn at positions 22 and 23 of the beta-amyloid fibrils with Italian mutation using solid-state NMR	Verification of the turn at positions 22 and 23 of the beta-amyloid fibrils with Italian mutation using solid-state NMR	Verification of the turn at positions 22 and 23 of the beta-amyloid fibrils with Italian mutation using solid-state NMR	Bioorg. Med. Chem., 13, 24, 6803-6809	Bioorg. Med. Chem., 13, 24, 6803-6809	Bioorg. Med. Chem., 13, 24, 6803-6809	2005	Refereed	English	Research paper(scientific journal)	Disclose to all
K. Irie*, K. Murakami, Y. Masuda, A. Morimoto, H. Ohigashi, R. Ohashi, K. Takegoshi, M. Nagao, T. Shimizu and T. Shirasawa	K. Irie*, K. Murakami, Y. Masuda, A. Morimoto, H. Ohigashi, R. Ohashi, K. Takegoshi, M. Nagao, T. Shimizu and T. Shirasawa	K. Irie*, K. Murakami, Y. Masuda, A. Morimoto, H. Ohigashi, R. Ohashi, K. Takegoshi, M. Nagao, T. Shimizu and T. Shirasawa	Structure of beta-amyloid fibrils and its relavence to their neurotoxicity:implications for the pathogenesis of Alzheimer's disease	Structure of beta-amyloid fibrils and its relavence to their neurotoxicity:implications for the pathogenesis of Alzheimer's disease	Structure of beta-amyloid fibrils and its relavence to their neurotoxicity:implications for the pathogenesis of Alzheimer's disease	J. Biosci. Bioeng., 99, 5, 437-447	J. Biosci. Bioeng., 99, 5, 437-447	J. Biosci. Bioeng., 99, 5, 437-447	2005	Refereed	English	Research paper(scientific journal)	Disclose to all
K. Irie*, Y. Nakagawa and H. Ohigashi	K. Irie*, Y. Nakagawa and H. Ohigashi	K. Irie*, Y. Nakagawa and H. Ohigashi	Toward the development of new medicinal leads with selectivity for protein kinase C isozymes	Toward the development of new medicinal leads with selectivity for protein kinase C isozymes	Toward the development of new medicinal leads with selectivity for protein kinase C isozymes	Chem. Rec., 5, 4, 185-195	Chem. Rec., 5, 4, 185-195	Chem. Rec., 5, 4, 185-195	2005	Refereed	English	Research paper(scientific journal)	Disclose to all
Y. Nakagawa, K. Irie*, Y. Komiya, H. Ohigashi and K. Tsuda	Y. Nakagawa, K. Irie*, Y. Komiya, H. Ohigashi and K. Tsuda	Y. Nakagawa, K. Irie*, Y. Komiya, H. Ohigashi and K. Tsuda	Synthesis, conformation and PKC isozyme surrogate binding of indolinelactam-Vs, new conformationally restricted analogues of (-)-indolactam-V	Synthesis, conformation and PKC isozyme surrogate binding of indolinelactam-Vs, new conformationally restricted analogues of (-)-indolactam-V	Synthesis, conformation and PKC isozyme surrogate binding of indolinelactam-Vs, new conformationally restricted analogues of (-)-indolactam-V	Tetrahedron, 60/33, 7077-7084	Tetrahedron, 60/33, 7077-7084	Tetrahedron, 60/33, 7077-7084	2004	Refereed	English	Research paper(scientific journal)	Disclose to all
K. Irie*, A. Masuda, M. Shindo, Y. Nakagawa and H. Ohigashi	K. Irie*, A. Masuda, M. Shindo, Y. Nakagawa and H. Ohigashi	K. Irie*, A. Masuda, M. Shindo, Y. Nakagawa and H. Ohigashi	Tumor promoter binding of the protein kinase C C1 homology domain peptides of RasGRPs, chimaerins, and Unc13s	Tumor promoter binding of the protein kinase C C1 homology domain peptides of RasGRPs, chimaerins, and Unc13s	Tumor promoter binding of the protein kinase C C1 homology domain peptides of RasGRPs, chimaerins, and Unc13s	Bioorg. Med. Chem., 12/17, 4575-4583	Bioorg. Med. Chem., 12/17, 4575-4583	Bioorg. Med. Chem., 12/17, 4575-4583	2004	Refereed	English	Research paper(scientific journal)	Disclose to all
A. Morimoto, K. Irie*, K. Murakami, Y. Masuda, H. Ohigashi, M. Nagao, H. Fukuda, T. Shimizu and T. Shirasawa	A. Morimoto, K. Irie*, K. Murakami, Y. Masuda, H. Ohigashi, M. Nagao, H. Fukuda, T. Shimizu and T. Shirasawa	A. Morimoto, K. Irie*, K. Murakami, Y. Masuda, H. Ohigashi, M. Nagao, H. Fukuda, T. Shimizu and T. Shirasawa	Analysis of the secondary structure of beta-amyloid (Abeta42) fibrils by systematic proline replacement	Analysis of the secondary structure of beta-amyloid (Abeta42) fibrils by systematic proline replacement	Analysis of the secondary structure of beta-amyloid (Abeta42) fibrils by systematic proline replacement	J. Biol. Chem., 279/50, 52781-52788	J. Biol. Chem., 279/50, 52781-52788	J. Biol. Chem., 279/50, 52781-52788	2004	Refereed	English	Research paper(scientific journal)	Disclose to all
入江一浩*、大東肇	入江一浩*、大東肇		ペプチド合成によるホルボールエステル受容体の機能解析	ペプチド合成によるホルボールエステル受容体の機能解析		化学と生物, 42/1, 54-62	化学と生物, 42/1, 54-62		2004	Refereed	Japanese	Research paper(scientific journal)	Disclose to all
K. Irie*, Y. Nakagawa and H. Ohigashi	K. Irie*, Y. Nakagawa and H. Ohigashi	K. Irie*, Y. Nakagawa and H. Ohigashi	Indolactam and benzolactam compounds as new medicinal leads with binding selectivity for C1 domains of protein kinase C isozymes	Indolactam and benzolactam compounds as new medicinal leads with binding selectivity for C1 domains of protein kinase C isozymes	Indolactam and benzolactam compounds as new medicinal leads with binding selectivity for C1 domains of protein kinase C isozymes	Curr. Pharm. Design, 10, 12, 1371-1385	Curr. Pharm. Design, 10, 12, 1371-1385	Curr. Pharm. Design, 10, 12, 1371-1385	2004	Refereed	English	Research paper(scientific journal)	Disclose to all
M. Shindo, K. Irie*, A. Masuda, H. Ohigashi, Y. Shirai, K. Miyasaki and N. Saito	M. Shindo, K. Irie*, A. Masuda, H. Ohigashi, Y. Shirai, K. Miyasaki and N. Saito	M. Shindo, K. Irie*, A. Masuda, H. Ohigashi, Y. Shirai, K. Miyasaki and N. Saito	Synthesis and phorbol ester binding of the cysteine-rich domains of diacylglycerol kinase (DGK) isozymes; DGKgamma and DGKbeta are new targets of tumor-promoting phorbol esters	Synthesis and phorbol ester binding of the cysteine-rich domains of diacylglycerol kinase (DGK) isozymes; DGKgamma and DGKbeta are new targets of tumor-promoting phorbol esters	Synthesis and phorbol ester binding of the cysteine-rich domains of diacylglycerol kinase (DGK) isozymes; DGKgamma and DGKbeta are new targets of tumor-promoting phorbol esters	J. Biol. Chem., 278/20, 18448-18454	J. Biol. Chem., 278/20, 18448-18454	J. Biol. Chem., 278/20, 18448-18454	2003	Refereed	English	Research paper(scientific journal)	Disclose to all
Y. Nakagawa, K. Irie*, N. Yamanaka, H. Ohigashi and K. Tsuda	Y. Nakagawa, K. Irie*, N. Yamanaka, H. Ohigashi and K. Tsuda	Y. Nakagawa, K. Irie*, N. Yamanaka, H. Ohigashi and K. Tsuda	Synthesis and binding selectivity of 7- and 15-decylbenzolactone-V8 for the C1 domains of protein kinase C isozymes	Synthesis and binding selectivity of 7- and 15-decylbenzolactone-V8 for the C1 domains of protein kinase C isozymes	Synthesis and binding selectivity of 7- and 15-decylbenzolactone-V8 for the C1 domains of protein kinase C isozymes	Bioorg. Med. Chem. Lett., 13/18, 3015-3019	Bioorg. Med. Chem. Lett., 13/18, 3015-3019	Bioorg. Med. Chem. Lett., 13/18, 3015-3019	2003	Refereed	English	Research paper(scientific journal)	Disclose to all
K. Murakami, K. Irie*, A. Morimoto, H. Ohigashi, M. Shindo, M. Nagao, T. Shimizu and T. Shirasawa	K. Murakami, K. Irie*, A. Morimoto, H. Ohigashi, M. Shindo, M. Nagao, T. Shimizu and T. Shirasawa	K. Murakami, K. Irie*, A. Morimoto, H. Ohigashi, M. Shindo, M. Nagao, T. Shimizu and T. Shirasawa	Neurotoxicity and physicochemical properties of Abeta mutant peptides from cerebral amyloid angiopathy: implication for the pathogenesis of cerebral amyloid angiopathy and Alzheimer's disease	Neurotoxicity and physicochemical properties of Abeta mutant peptides from cerebral amyloid angiopathy: implication for the pathogenesis of cerebral amyloid angiopathy and Alzheimer's disease	Neurotoxicity and physicochemical properties of Abeta mutant peptides from cerebral amyloid angiopathy: implication for the pathogenesis of cerebral amyloid angiopathy and Alzheimer's disease	J. Biol. Chem., 278/46, 46179-46187	J. Biol. Chem., 278/46, 46179-46187	J. Biol. Chem., 278/46, 46179-46187	2003	Refereed	English	Research paper(scientific journal)	Disclose to all
M. Shindo, K. Irie*, H. Fukuda and H. Ohigashi	M. Shindo, K. Irie*, H. Fukuda and H. Ohigashi	M. Shindo, K. Irie*, H. Fukuda and H. Ohigashi	Analysis of the non-covalent interaction between metal ions and the cysteine-rich domain of protein kinase C eta by electrospray ionization mass spectrometry	Analysis of the non-covalent interaction between metal ions and the cysteine-rich domain of protein kinase C eta by electrospray ionization mass spectrometry	Analysis of the non-covalent interaction between metal ions and the cysteine-rich domain of protein kinase C eta by electrospray ionization mass spectrometry	Bioorg. Med. Chem., 11/23, 5075-5082	Bioorg. Med. Chem., 11/23, 5075-5082	Bioorg. Med. Chem., 11/23, 5075-5082	2003	Refereed	English	Research paper(scientific journal)	Disclose to all
Y. Nakagawa, K. Irie*, A. Masuda and H. Ohigashi	Y. Nakagawa, K. Irie*, A. Masuda and H. Ohigashi	Y. Nakagawa, K. Irie*, A. Masuda and H. Ohigashi	Synthesis, conformation and PKC isozyme surrogate binding of new lactone analogues of benzolactam-V8s	Synthesis, conformation and PKC isozyme surrogate binding of new lactone analogues of benzolactam-V8s	Synthesis, conformation and PKC isozyme surrogate binding of new lactone analogues of benzolactam-V8s	Tetrahedron, 58/6, 2101-2115	Tetrahedron, 58/6, 2101-2115	Tetrahedron, 58/6, 2101-2115	2002	Refereed	English	Research paper(scientific journal)	Disclose to all
K. Murakami, K. Irie*, A. Morimoto, H. Ohigashi, M. Shindo, M. Nagao, T. Shimizu and T. Shirasawa	K. Murakami, K. Irie*, A. Morimoto, H. Ohigashi, M. Shindo, M. Nagao, T. Shimizu and T. Shirasawa	K. Murakami, K. Irie*, A. Morimoto, H. Ohigashi, M. Shindo, M. Nagao, T. Shimizu and T. Shirasawa	Synthesis, aggregation, neurotoxicity, and secondary structure of various Abeta1-42 mutants of familial Alzheimer's disease at positions 21-23	Synthesis, aggregation, neurotoxicity, and secondary structure of various Abeta1-42 mutants of familial Alzheimer's disease at positions 21-23	Synthesis, aggregation, neurotoxicity, and secondary structure of various Abeta1-42 mutants of familial Alzheimer's disease at positions 21-23	Biochem. Biophys. Res. Commun., 294/1, 5-10	Biochem. Biophys. Res. Commun., 294/1, 5-10	Biochem. Biophys. Res. Commun., 294/1, 5-10	2002	Refereed	English	Research paper(scientific journal)	Disclose to all
A. Masuda, K. Irie*, Y. Nakagawa and H. Ohigashi	A. Masuda, K. Irie*, Y. Nakagawa and H. Ohigashi	A. Masuda, K. Irie*, Y. Nakagawa and H. Ohigashi	Binding selectivity of conformationally restricted analogues of (-)-indolactam-V to the C1 domains of protein kinase C isozymes	Binding selectivity of conformationally restricted analogues of (-)-indolactam-V to the C1 domains of protein kinase C isozymes	Binding selectivity of conformationally restricted analogues of (-)-indolactam-V to the C1 domains of protein kinase C isozymes	Biosci. Biotechnol. Biochem., 66/7, 1615-1617	Biosci. Biotechnol. Biochem., 66/7, 1615-1617	Biosci. Biotechnol. Biochem., 66/7, 1615-1617	2002	Refereed	English	Research paper(scientific journal)	Disclose to all
A. Morimoto, K. Irie*, K. Murakami, H. Ohigashi, M. Shindo, M. Nagao, T. Shimizu and T. Shirasawa	A. Morimoto, K. Irie*, K. Murakami, H. Ohigashi, M. Shindo, M. Nagao, T. Shimizu and T. Shirasawa	A. Morimoto, K. Irie*, K. Murakami, H. Ohigashi, M. Shindo, M. Nagao, T. Shimizu and T. Shirasawa	Aggregation and neurotoxicity of mutant amyloid beta (Abeta) peptides with proline replacement: importance of turn formation at positions 22 and 23	Aggregation and neurotoxicity of mutant amyloid beta (Abeta) peptides with proline replacement: importance of turn formation at positions 22 and 23	Aggregation and neurotoxicity of mutant amyloid beta (Abeta) peptides with proline replacement: importance of turn formation at positions 22 and 23	Biochem. Biophys. Res. Commun., 295/2, 306-311	Biochem. Biophys. Res. Commun., 295/2, 306-311	Biochem. Biophys. Res. Commun., 295/2, 306-311	2002	Refereed	English	Research paper(scientific journal)	Disclose to all
入江一浩*、大東肇	入江一浩*、大東肇		プロテインキナーゼＣのシステインリッチドメインの化学合成、機能解析とドラッグデザイン	プロテインキナーゼＣのシステインリッチドメインの化学合成、機能解析とドラッグデザイン		有機合成化学協会誌, 60/6, 563-572	有機合成化学協会誌, 60/6, 563-572		2002	Refereed	Japanese	Research paper(scientific journal)	Disclose to all
K. Irie*, A. Nakahara, Y. Nakagawa, H. Ohigashi, M. Shindo, H. Fukuda, H. Konishi, U. Kikkawa, K. Kashiwagi and N. Saito	K. Irie*, A. Nakahara, Y. Nakagawa, H. Ohigashi, M. Shindo, H. Fukuda, H. Konishi, U. Kikkawa, K. Kashiwagi and N. Saito	K. Irie*, A. Nakahara, Y. Nakagawa, H. Ohigashi, M. Shindo, H. Fukuda, H. Konishi, U. Kikkawa, K. Kashiwagi and N. Saito	Establishment of a binding assay for protein kinase C isozymes using synthetic C1 peptides and development of new medicinal leads with protein kinase C isozyme and C1 domain selectivity	Establishment of a binding assay for protein kinase C isozymes using synthetic C1 peptides and development of new medicinal leads with protein kinase C isozyme and C1 domain selectivity	Establishment of a binding assay for protein kinase C isozymes using synthetic C1 peptides and development of new medicinal leads with protein kinase C isozyme and C1 domain selectivity	Pharmacol. Ther., 93/2-3, 271-281	Pharmacol. Ther., 93/2-3, 271-281	Pharmacol. Ther., 93/2-3, 271-281	2002	Refereed	English	Research paper(scientific journal)	Disclose to all
M. Tanaka, K. Irie*, Y. Nakagawa, Y. Nakamura, H. Ohigashi and P. A. Wender	M. Tanaka, K. Irie*, Y. Nakagawa, Y. Nakamura, H. Ohigashi and P. A. Wender	M. Tanaka, K. Irie*, Y. Nakagawa, Y. Nakamura, H. Ohigashi and P. A. Wender	The C4 hydroxyl group of phorbol esters is not necessary for protein kinase C binding	The C4 hydroxyl group of phorbol esters is not necessary for protein kinase C binding	The C4 hydroxyl group of phorbol esters is not necessary for protein kinase C binding	Bioorg. Med. Chem. Lett., 11/5, 719-722	Bioorg. Med. Chem. Lett., 11/5, 719-722	Bioorg. Med. Chem. Lett., 11/5, 719-722	2001	Refereed	English	Research paper(scientific journal)	Disclose to all
Y. Nakagawa, K. Irie*, Y. Nakamura and H. Ohigashi	Y. Nakagawa, K. Irie*, Y. Nakamura and H. Ohigashi	Y. Nakagawa, K. Irie*, Y. Nakamura and H. Ohigashi	The amide hydrogen of (-)-indolactam-V and benzolactam-V8's plays a critical role in protein kinase C binding and tumor-promoting activities	The amide hydrogen of (-)-indolactam-V and benzolactam-V8's plays a critical role in protein kinase C binding and tumor-promoting activities	The amide hydrogen of (-)-indolactam-V and benzolactam-V8's plays a critical role in protein kinase C binding and tumor-promoting activities	Bioorg. Med. Chem. Lett., 11/5, 723-728	Bioorg. Med. Chem. Lett., 11/5, 723-728	Bioorg. Med. Chem. Lett., 11/5, 723-728	2001	Refereed	English	Research paper(scientific journal)	Disclose to all
M. Shindo, K. Irie*, A. Nakahara, H. Ohigashi, H. Konishi, U. Kikkawa, H. Fukuda and P. A. Wender	M. Shindo, K. Irie*, A. Nakahara, H. Ohigashi, H. Konishi, U. Kikkawa, H. Fukuda and P. A. Wender	M. Shindo, K. Irie*, A. Nakahara, H. Ohigashi, H. Konishi, U. Kikkawa, H. Fukuda and P. A. Wender	Toward the identification of selective modulators of protein kinase C (PKC) isozymes: establishment of a binding assay for PKC isozymes using synthetic C1 peptide receptors and identification of the critical residues involved in the phorbol ester binding	Toward the identification of selective modulators of protein kinase C (PKC) isozymes: establishment of a binding assay for PKC isozymes using synthetic C1 peptide receptors and identification of the critical residues involved in the phorbol ester binding	Toward the identification of selective modulators of protein kinase C (PKC) isozymes: establishment of a binding assay for PKC isozymes using synthetic C1 peptide receptors and identification of the critical residues involved in the phorbol ester binding	Bioorg. Med. Chem., 9/8, 2073-2081	Bioorg. Med. Chem., 9/8, 2073-2081	Bioorg. Med. Chem., 9/8, 2073-2081	2001	Refereed	English	Research paper(scientific journal)	Disclose to all
M. Shindo, K. Irie*, H. Ohigashi, M. Kuriyama and N. Saito	M. Shindo, K. Irie*, H. Ohigashi, M. Kuriyama and N. Saito	M. Shindo, K. Irie*, H. Ohigashi, M. Kuriyama and N. Saito	Diacylglycerol kinase gamma is one of the specific receptors of tumor-promoting phorbol esters	Diacylglycerol kinase gamma is one of the specific receptors of tumor-promoting phorbol esters	Diacylglycerol kinase gamma is one of the specific receptors of tumor-promoting phorbol esters	Biochem. Biophys. Res. Commun., 289/2, 451-456	Biochem. Biophys. Res. Commun., 289/2, 451-456	Biochem. Biophys. Res. Commun., 289/2, 451-456	2001	Refereed	English	Research paper(scientific journal)	Disclose to all
Y. Nakagawa, K. Irie*, H. Ohigashi, H. Hayashi and P. A. Wender	Y. Nakagawa, K. Irie*, H. Ohigashi, H. Hayashi and P. A. Wender	Y. Nakagawa, K. Irie*, H. Ohigashi, H. Hayashi and P. A. Wender	Synthesis and PKC isozyme surrogate binding of indothiolactam-V, a new thioamide analogue of tumor promoting indolactam-V	Synthesis and PKC isozyme surrogate binding of indothiolactam-V, a new thioamide analogue of tumor promoting indolactam-V	Synthesis and PKC isozyme surrogate binding of indothiolactam-V, a new thioamide analogue of tumor promoting indolactam-V	Bioorg. Med. Chem. Lett., 10/18, 2087-2090	Bioorg. Med. Chem. Lett., 10/18, 2087-2090	Bioorg. Med. Chem. Lett., 10/18, 2087-2090	2000	Refereed	English	Research paper(scientific journal)	Disclose to all
K. Irie*, A. Nakahara, Y. Ikawa, M. Tanaka, Y. Nakagawa, Y. Nakamura, H. Ohigashi and P. A. Wender	K. Irie*, A. Nakahara, Y. Ikawa, M. Tanaka, Y. Nakagawa, Y. Nakamura, H. Ohigashi and P. A. Wender	K. Irie*, A. Nakahara, Y. Ikawa, M. Tanaka, Y. Nakagawa, Y. Nakamura, H. Ohigashi and P. A. Wender	Synthesis and tumor-promoting activities of 12-epi-phorbol-12,13-dibutyrate	Synthesis and tumor-promoting activities of 12-epi-phorbol-12,13-dibutyrate	Synthesis and tumor-promoting activities of 12-epi-phorbol-12,13-dibutyrate	Biosci. Biotechnol. Biochem., 64/11, 2429-2436	Biosci. Biotechnol. Biochem., 64/11, 2429-2436	Biosci. Biotechnol. Biochem., 64/11, 2429-2436	2000	Refereed	English	Research paper(scientific journal)	Disclose to all
中川　優*, 入江一浩	中川　優*, 入江一浩		発がんプロモーターのnPKC C1Bドメインへの選択的結合	発がんプロモーターのnPKC C1Bドメインへの選択的結合		バイオサイエンスとインダストリー, 58/8, 570-571	バイオサイエンスとインダストリー, 58/8, 570-571		2000	Refereed	Japanese	Research paper(scientific journal)	Disclose to all
H. Fukuda, K. Irie*, A. Nakahara, H. Ohigashi and P. A. Wender	H. Fukuda, K. Irie*, A. Nakahara, H. Ohigashi and P. A. Wender	H. Fukuda, K. Irie*, A. Nakahara, H. Ohigashi and P. A. Wender	Solid-phase synthesis, mass spectrometic analysis of the zinc-folding, and phorbol ester-binding studies of the 116-mer peptide containing the tandem cysteine-rich C1 domains of protein kinase C gamma	Solid-phase synthesis, mass spectrometic analysis of the zinc-folding, and phorbol ester-binding studies of the 116-mer peptide containing the tandem cysteine-rich C1 domains of protein kinase C gamma	Solid-phase synthesis, mass spectrometic analysis of the zinc-folding, and phorbol ester-binding studies of the 116-mer peptide containing the tandem cysteine-rich C1 domains of protein kinase C gamma	Bioorg. Med. Chem., 7/6, 1213-1221	Bioorg. Med. Chem., 7/6, 1213-1221	Bioorg. Med. Chem., 7/6, 1213-1221	1999	Refereed	English	Research paper(scientific journal)	Disclose to all
P. A. Wender*, B. Lippa, C.-M. Park, K. Irie, A. Nakahara and H. Ohigashi	P. A. Wender*, B. Lippa, C.-M. Park, K. Irie, A. Nakahara and H. Ohigashi	P. A. Wender*, B. Lippa, C.-M. Park, K. Irie, A. Nakahara and H. Ohigashi	Selective binding of bryostatin analogues to the cysteine rich domains of protein kinase C isozymes	Selective binding of bryostatin analogues to the cysteine rich domains of protein kinase C isozymes	Selective binding of bryostatin analogues to the cysteine rich domains of protein kinase C isozymes	Bioorg. Med. Chem. Lett., 9/12, 1687-1690	Bioorg. Med. Chem. Lett., 9/12, 1687-1690	Bioorg. Med. Chem. Lett., 9/12, 1687-1690	1999	Refereed	English	Research paper(scientific journal)	Disclose to all
K. Irie*, A. Nakahara, H. Ohigashi, H. Fukuda, P. A. Wender, H. Konishi and U. Kikkawa	K. Irie*, A. Nakahara, H. Ohigashi, H. Fukuda, P. A. Wender, H. Konishi and U. Kikkawa	K. Irie*, A. Nakahara, H. Ohigashi, H. Fukuda, P. A. Wender, H. Konishi and U. Kikkawa	Synthesis and phorbol ester-binding studies of the individual cysteine-rich motifs of protein kinase D	Synthesis and phorbol ester-binding studies of the individual cysteine-rich motifs of protein kinase D	Synthesis and phorbol ester-binding studies of the individual cysteine-rich motifs of protein kinase D	Bioorg. Med. Chem. Lett., 9/17, 2487-2490	Bioorg. Med. Chem. Lett., 9/17, 2487-2490	Bioorg. Med. Chem. Lett., 9/17, 2487-2490	1999	Refereed	English	Research paper(scientific journal)	Disclose to all
P. A. Wender*, M. F. T. Koehler, D. L. Wright and K. Irie	P. A. Wender*, M. F. T. Koehler, D. L. Wright and K. Irie	P. A. Wender*, M. F. T. Koehler, D. L. Wright and K. Irie	Mapping phorbol ester binding domains of protein kinase C (PKC) : the design, synthesis and biological activity of novel phorbol ester dimers	Mapping phorbol ester binding domains of protein kinase C (PKC) : the design, synthesis and biological activity of novel phorbol ester dimers	Mapping phorbol ester binding domains of protein kinase C (PKC) : the design, synthesis and biological activity of novel phorbol ester dimers	Synthesis, /SI, 1401-1406	Synthesis, /SI, 1401-1406	Synthesis, /SI, 1401-1406	1999	Refereed	English	Research paper(scientific journal)	Disclose to all
K. Irie*, S. Tomimatsu, Y. Nakagawa, H. Ohigashi and H. Hayashi	K. Irie*, S. Tomimatsu, Y. Nakagawa, H. Ohigashi and H. Hayashi	K. Irie*, S. Tomimatsu, Y. Nakagawa, H. Ohigashi and H. Hayashi	Isolation of (-)-14-O-malonylindolactam-V as a possible precursor of (-)-14-O-acetylindolactam-V from Streptomyces blastmyceticum	Isolation of (-)-14-O-malonylindolactam-V as a possible precursor of (-)-14-O-acetylindolactam-V from Streptomyces blastmyceticum	Isolation of (-)-14-O-malonylindolactam-V as a possible precursor of (-)-14-O-acetylindolactam-V from Streptomyces blastmyceticum	Biosci. Biotechnol. Biochem., 63/9, 1669-1670	Biosci. Biotechnol. Biochem., 63/9, 1669-1670	Biosci. Biotechnol. Biochem., 63/9, 1669-1670	1999	Refereed	English	Research paper(scientific journal)	Disclose to all
P. A. Wender*, T. A. Kirschberg, P. D. Williams, H. M. M. Bastiaans and K. Irie	P. A. Wender*, T. A. Kirschberg, P. D. Williams, H. M. M. Bastiaans and K. Irie	P. A. Wender*, T. A. Kirschberg, P. D. Williams, H. M. M. Bastiaans and K. Irie	A new class of simplified phorbol ester analogues : synthesis and binding to PKC and ηPKC-C1B (ηPKC-CRD2)	A new class of simplified phorbol ester analogues : synthesis and binding to PKC and ηPKC-C1B (ηPKC-CRD2)	A new class of simplified phorbol ester analogues : synthesis and binding to PKC and ηPKC-C1B (ηPKC-CRD2)	Org. Lett., 1/7, 1009-1012	Org. Lett., 1/7, 1009-1012	Org. Lett., 1/7, 1009-1012	1999	Refereed	English	Research paper(scientific journal)	Disclose to all
Y. Nakagawa, K. Irie*, Y. Nakamura, H. Ohigashi and H. Hayashi	Y. Nakagawa, K. Irie*, Y. Nakamura, H. Ohigashi and H. Hayashi	Y. Nakagawa, K. Irie*, Y. Nakamura, H. Ohigashi and H. Hayashi	Synthesis and biological activities of (-)-6-n-octyl-indolactam-V, a new potent analogue of the tumor promoter (-)-indolactam-V	Synthesis and biological activities of (-)-6-n-octyl-indolactam-V, a new potent analogue of the tumor promoter (-)-indolactam-V	Synthesis and biological activities of (-)-6-n-octyl-indolactam-V, a new potent analogue of the tumor promoter (-)-indolactam-V	Biosci. Biotechnol. Biochem., 62/8, 1568-1573	Biosci. Biotechnol. Biochem., 62/8, 1568-1573	Biosci. Biotechnol. Biochem., 62/8, 1568-1573	1998	Refereed	English	Research paper(scientific journal)	Disclose to all
K. Irie, K. Oie, A. Nakahara, Y. Yanai, H. Ohigashi, P. A. Wender, H. Fukuda, H. Konishi and U. Kikkawa	K. Irie, K. Oie, A. Nakahara, Y. Yanai, H. Ohigashi, P. A. Wender, H. Fukuda, H. Konishi and U. Kikkawa	K. Irie, K. Oie, A. Nakahara, Y. Yanai, H. Ohigashi, P. A. Wender, H. Fukuda, H. Konishi and U. Kikkawa	Molecular Basis for protein kinase C isozyme-selective binding : the synthesis, folding, and phorbol ester binding of the cysteine-rich domains of all protein kinase C isozymes	Molecular Basis for protein kinase C isozyme-selective binding : the synthesis, folding, and phorbol ester binding of the cysteine-rich domains of all protein kinase C isozymes	Molecular Basis for protein kinase C isozyme-selective binding : the synthesis, folding, and phorbol ester binding of the cysteine-rich domains of all protein kinase C isozymes	J. Am. Chem. Soc., 120/36, 9159-9167	J. Am. Chem. Soc., 120/36, 9159-9167	J. Am. Chem. Soc., 120/36, 9159-9167	1998	Refereed	English	Research paper(scientific journal)	Disclose to all
K. Irie*, Y. Nakagawa, S. Tomimatsu and H. Ohigashi	K. Irie*, Y. Nakagawa, S. Tomimatsu and H. Ohigashi	K. Irie*, Y. Nakagawa, S. Tomimatsu and H. Ohigashi	Biosynthesis of the monoterpenoid moiety of teleocidins via the non-mevalonate pathway in Streptomyces	Biosynthesis of the monoterpenoid moiety of teleocidins via the non-mevalonate pathway in Streptomyces	Biosynthesis of the monoterpenoid moiety of teleocidins via the non-mevalonate pathway in Streptomyces	Tetrahedron Lett., 39/43, 7929-7930	Tetrahedron Lett., 39/43, 7929-7930	Tetrahedron Lett., 39/43, 7929-7930	1998	Refereed	English	Research paper(scientific journal)	Disclose to all
H. Fukuda, K. Irie*, A. Nakahara, K. Oie, H. Ohigashi and P. A. Wender	H. Fukuda, K. Irie*, A. Nakahara, K. Oie, H. Ohigashi and P. A. Wender	H. Fukuda, K. Irie*, A. Nakahara, K. Oie, H. Ohigashi and P. A. Wender	Synthesis and binding studies of the 116-mer peptide containing the double cysteine-rich motifs of protein kinase C gamma	Synthesis and binding studies of the 116-mer peptide containing the double cysteine-rich motifs of protein kinase C gamma	Synthesis and binding studies of the 116-mer peptide containing the double cysteine-rich motifs of protein kinase C gamma	Tetrahedron Lett., 39/43, 7943-7946	Tetrahedron Lett., 39/43, 7943-7946	Tetrahedron Lett., 39/43, 7943-7946	1998	Refereed	English	Research paper(scientific journal)	Disclose to all
入江一浩	入江一浩		プロテインキナーゼ機能ドメインの化学合成	プロテインキナーゼ機能ドメインの化学合成		バイオサイエンスとインダストリー, 56/8, 541-544	バイオサイエンスとインダストリー, 56/8, 541-544		1998	Refereed	Japanese	Research paper(scientific journal)	Disclose to all
入江一浩	入江一浩		ビオチンを用いた新しい光アフィニティーラベリング法の開発と応用	ビオチンを用いた新しい光アフィニティーラベリング法の開発と応用		化学と工業, 51/10, 1634	化学と工業, 51/10, 1634		1998		Japanese	Research paper(scientific journal)	Disclose to all
P. A. Wender*, Y. M.-Cantalejo, A. J. Carpenter, A. Chiu, J. De Brabander, P.G. Harran, J.-M. Jimenez, M. F. T. Koehler, B. Lippa, J. A. Morrison, S. G. Mϋller, S. N. Mϋller, C.-M. Park, M. Shiozaki, C. Siedenbiedel, D. J. Skalitzky, M. Tanaka and K. Irie	P. A. Wender*, Y. M.-Cantalejo, A. J. Carpenter, A. Chiu, J. De Brabander, P.G. Harran, J.-M. Jimenez, M. F. T. Koehler, B. Lippa, J. A. Morrison, S. G. Mϋller, S. N. Mϋller, C.-M. Park, M. Shiozaki, C. Siedenbiedel, D. J. Skalitzky, M. Tanaka and K. Irie	P. A. Wender*, Y. M.-Cantalejo, A. J. Carpenter, A. Chiu, J. De Brabander, P.G. Harran, J.-M. Jimenez, M. F. T. Koehler, B. Lippa, J. A. Morrison, S. G. Mϋller, S. N. Mϋller, C.-M. Park, M. Shiozaki, C. Siedenbiedel, D. J. Skalitzky, M. Tanaka and K. Irie	The chemistry-medicine continuum: synthetic, computer, spectroscopic and biological studies on new chemotherapeutic leads	The chemistry-medicine continuum: synthetic, computer, spectroscopic and biological studies on new chemotherapeutic leads	The chemistry-medicine continuum: synthetic, computer, spectroscopic and biological studies on new chemotherapeutic leads	Pure & Appl. Chem.,70/3, 539-546	Pure & Appl. Chem.,70/3, 539-546	Pure & Appl. Chem.,70/3, 539-546	1998	Refereed	English	Research paper(scientific journal)	Disclose to all
Y. Nakagawa, K. Irie*, Y. Nakamura, H. Ohigashi and H. Hayashi	Y. Nakagawa, K. Irie*, Y. Nakamura, H. Ohigashi and H. Hayashi	Y. Nakagawa, K. Irie*, Y. Nakamura, H. Ohigashi and H. Hayashi	Synthesis and biological activities of indolactone-V, the lactone analogue of the tumor promoter (-)-indolactam-V	Synthesis and biological activities of indolactone-V, the lactone analogue of the tumor promoter (-)-indolactam-V	Synthesis and biological activities of indolactone-V, the lactone analogue of the tumor promoter (-)-indolactam-V	Biosci. Biotechnol. Biochem., 61/8, 1415-1417	Biosci. Biotechnol. Biochem., 61/8, 1415-1417	Biosci. Biotechnol. Biochem., 61/8, 1415-1417	1997	Refereed	English	Research paper(scientific journal)	Disclose to all
Y. Yanai, K. Irie, H. Ohigashi and P. A. Wender	Y. Yanai, K. Irie, H. Ohigashi and P. A. Wender	Y. Yanai, K. Irie, H. Ohigashi and P. A. Wender	Synthesis and characterization of the first cysteine-rich domain of novel protein kinase C	Synthesis and characterization of the first cysteine-rich domain of novel protein kinase C	Synthesis and characterization of the first cysteine-rich domain of novel protein kinase C	Bioorg. Med. Chem. Lett., 7/2, 117-122	Bioorg. Med. Chem. Lett., 7/2, 117-122	Bioorg. Med. Chem. Lett., 7/2, 117-122	1997	Refereed	English	Research paper(scientific journal)	Disclose to all
K. Irie, Y. Yanai, K. Oie, H. Ohigashi and P. A. Wender	K. Irie, Y. Yanai, K. Oie, H. Ohigashi and P. A. Wender	K. Irie, Y. Yanai, K. Oie, H. Ohigashi and P. A. Wender	Protein kinase C regulatory domain surrogate peptides : effects of metal ions on folding, phorbol ester-binding, and selectivity	Protein kinase C regulatory domain surrogate peptides : effects of metal ions on folding, phorbol ester-binding, and selectivity	Protein kinase C regulatory domain surrogate peptides : effects of metal ions on folding, phorbol ester-binding, and selectivity	Bioorg. Med. Chem. Lett., 7/8, 965-970	Bioorg. Med. Chem. Lett., 7/8, 965-970	Bioorg. Med. Chem. Lett., 7/8, 965-970	1997	Refereed	English	Research paper(scientific journal)	Disclose to all
K. Irie, Y. Yanai, K. Oie, J. Ishizawa, Y. Nakagawa, H. Ohigashi, P. A. Wender and U. Kikkawa	K. Irie, Y. Yanai, K. Oie, J. Ishizawa, Y. Nakagawa, H. Ohigashi, P. A. Wender and U. Kikkawa	K. Irie, Y. Yanai, K. Oie, J. Ishizawa, Y. Nakagawa, H. Ohigashi, P. A. Wender and U. Kikkawa	Comparison of chemical characteristics of the first and the second cysteine-rich domains of protein kinase Cγ	Comparison of chemical characteristics of the first and the second cysteine-rich domains of protein kinase Cγ	Comparison of chemical characteristics of the first and the second cysteine-rich domains of protein kinase Cγ	Bioorg. Med. Chem., 5/8, 1725-1737	Bioorg. Med. Chem., 5/8, 1725-1737	Bioorg. Med. Chem., 5/8, 1725-1737	1997	Refereed	English	Research paper(scientific journal)	Disclose to all
入江一浩	入江一浩		プロテインキナーゼＣの２つのzinc finger モチーフの機能と役割	プロテインキナーゼＣの２つのzinc finger モチーフの機能と役割		化学と生物, 35/9, 638-639	化学と生物, 35/9, 638-639		1997	Refereed	Japanese	Research paper(scientific journal)	Disclose to all
K. Irie, T. Isaka, Y. Iwata, Y. Yanai, Y. Nakamura, F. Koizumi, H. Ohigashi, P. A. Wender, Y. Satomi and H. Nishino	K. Irie, T. Isaka, Y. Iwata, Y. Yanai, Y. Nakamura, F. Koizumi, H. Ohigashi, P. A. Wender, Y. Satomi and H. Nishino	K. Irie, T. Isaka, Y. Iwata, Y. Yanai, Y. Nakamura, F. Koizumi, H. Ohigashi, P. A. Wender, Y. Satomi and H. Nishino	Synthesis and biological activities of new conformationally restricted analogues of (-)-indolactam-V: elucidation of the biologically active conformation of the tumor promoting teleocidins	Synthesis and biological activities of new conformationally restricted analogues of (-)-indolactam-V: elucidation of the biologically active conformation of the tumor promoting teleocidins	Synthesis and biological activities of new conformationally restricted analogues of (-)-indolactam-V: elucidation of the biologically active conformation of the tumor promoting teleocidins	J. Am. Chem. Soc., 118/44, 10733-10743	J. Am. Chem. Soc., 118/44, 10733-10743	J. Am. Chem. Soc., 118/44, 10733-10743	1996	Refereed	English	Research paper(scientific journal)	Disclose to all
K. Irie, T. Ishii, H. Ohigashi, P. A. Wender, B. L. Miller and N. Takeda	K. Irie, T. Ishii, H. Ohigashi, P. A. Wender, B. L. Miller and N. Takeda	K. Irie, T. Ishii, H. Ohigashi, P. A. Wender, B. L. Miller and N. Takeda	Synthesis and characterization of new photolabile phorbol esters for affinity labeling of protein kinase C	Synthesis and characterization of new photolabile phorbol esters for affinity labeling of protein kinase C	Synthesis and characterization of new photolabile phorbol esters for affinity labeling of protein kinase C	J. Org. Chem., 61/6, 2164-2173	J. Org. Chem., 61/6, 2164-2173	J. Org. Chem., 61/6, 2164-2173	1996	Refereed	English	Research paper(scientific journal)	Disclose to all
K. Irie, Y. Yanai, H. Ohigashi, P. A. Wender and B. L. Miller	K. Irie, Y. Yanai, H. Ohigashi, P. A. Wender and B. L. Miller	K. Irie, Y. Yanai, H. Ohigashi, P. A. Wender and B. L. Miller	Synthesis and characterization of the second cysteine-rich region of mouse skin PKCη	Synthesis and characterization of the second cysteine-rich region of mouse skin PKCη	Synthesis and characterization of the second cysteine-rich region of mouse skin PKCη	Bioorg. Med. Chem. Lett., 6/4, 353-356	Bioorg. Med. Chem. Lett., 6/4, 353-356	Bioorg. Med. Chem. Lett., 6/4, 353-356	1996	Refereed	English	Research paper(scientific journal)	Disclose to all
K. Irie*, Y. Nakamura, H. Ohigashi, H. Tokuyama, S. Yamago and E. Nakamura	K. Irie*, Y. Nakamura, H. Ohigashi, H. Tokuyama, S. Yamago and E. Nakamura	K. Irie*, Y. Nakamura, H. Ohigashi, H. Tokuyama, S. Yamago and E. Nakamura	Photocytotoxicity of water-soluble fullerene derivatives	Photocytotoxicity of water-soluble fullerene derivatives	Photocytotoxicity of water-soluble fullerene derivatives	Biosci. Biotechnol. Biochem., 60/8, 1359-1361	Biosci. Biotechnol. Biochem., 60/8, 1359-1361	Biosci. Biotechnol. Biochem., 60/8, 1359-1361	1996	Refereed	English	Research paper(scientific journal)	Disclose to all
入江一浩	入江一浩		プロテインキナーゼＣのホルボールエステル結合部位の光アフィニティーテベリングによる構造解析	プロテインキナーゼＣのホルボールエステル結合部位の光アフィニティーテベリングによる構造解析		生化学, 68/2, 129-132	生化学, 68/2, 129-132		1996	Refereed	Japanese	Research paper(scientific journal)	Disclose to all
入江一浩*, 大東肇	入江一浩*, 大東肇		プロテインキナーゼＣのホルボールエステル結合部位の合成と化学的特性	プロテインキナーゼＣのホルボールエステル結合部位の合成と化学的特性		有機合成化学協会誌, 54/12, 1024-1033	有機合成化学協会誌, 54/12, 1024-1033		1996	Refereed	Japanese	Research paper(scientific journal)	Disclose to all
P. A. Wender*, K. Irie and B. L. Miller	P. A. Wender*, K. Irie and B. L. Miller	P. A. Wender*, K. Irie and B. L. Miller	Identification, activity, and structural studies of peptides incorporating the phorbol ester-binding domain of protein kinase C	Identification, activity, and structural studies of peptides incorporating the phorbol ester-binding domain of protein kinase C	Identification, activity, and structural studies of peptides incorporating the phorbol ester-binding domain of protein kinase C	Proc. Natl. Acad. Sci. USA, 92/1, 239-243	Proc. Natl. Acad. Sci. USA, 92/1, 239-243	Proc. Natl. Acad. Sci. USA, 92/1, 239-243	1995	Refereed	English	Research paper(scientific journal)	Disclose to all
K. Irie*, M. Iguchi, T. Oda, Y. Suzuki, S. Okuno, H. Ohigashi, K. Koshimizu, H. Hayashi, M. Arai, H. Nishino and A. Iwashima	K. Irie*, M. Iguchi, T. Oda, Y. Suzuki, S. Okuno, H. Ohigashi, K. Koshimizu, H. Hayashi, M. Arai, H. Nishino and A. Iwashima	K. Irie*, M. Iguchi, T. Oda, Y. Suzuki, S. Okuno, H. Ohigashi, K. Koshimizu, H. Hayashi, M. Arai, H. Nishino and A. Iwashima	Synthesis of 6-substituted indolactams by microbial conversion	Synthesis of 6-substituted indolactams by microbial conversion	Synthesis of 6-substituted indolactams by microbial conversion	Tetrahedron, 51/22, 6255-6266	Tetrahedron, 51/22, 6255-6266	Tetrahedron, 51/22, 6255-6266	1995	Refereed	English	Research paper(scientific journal)	Disclose to all
K. Irie*, F. Koizumi, Y. Iwata, T. Ishii, Y. Yanai, Y. Nakamura, H. Ohigashi and P. A. Wender	K. Irie*, F. Koizumi, Y. Iwata, T. Ishii, Y. Yanai, Y. Nakamura, H. Ohigashi and P. A. Wender	K. Irie*, F. Koizumi, Y. Iwata, T. Ishii, Y. Yanai, Y. Nakamura, H. Ohigashi and P. A. Wender	Synthesis and biological activities of new conformationally fixed analogues of (-)-indolactam-V, the core structure of tumor-promoting teleocidins	Synthesis and biological activities of new conformationally fixed analogues of (-)-indolactam-V, the core structure of tumor-promoting teleocidins	Synthesis and biological activities of new conformationally fixed analogues of (-)-indolactam-V, the core structure of tumor-promoting teleocidins	Bioorg. Med. Chem. Lett., 5/5, 453-458	Bioorg. Med. Chem. Lett., 5/5, 453-458	Bioorg. Med. Chem. Lett., 5/5, 453-458	1995	Refereed	English	Research paper(scientific journal)	Disclose to all
S. Okuno, K. Irie*, Y. Suzuki, K. Koshimizu, H. Nishino and A. Iwashima	S. Okuno, K. Irie*, Y. Suzuki, K. Koshimizu, H. Nishino and A. Iwashima	S. Okuno, K. Irie*, Y. Suzuki, K. Koshimizu, H. Nishino and A. Iwashima	Synthesis and biological activities of fluorine-substituted (-)-indolactam-V, the core structure of tumor promoter teleocidins	Synthesis and biological activities of fluorine-substituted (-)-indolactam-V, the core structure of tumor promoter teleocidins	Synthesis and biological activities of fluorine-substituted (-)-indolactam-V, the core structure of tumor promoter teleocidins	Bioorg. Med. Chem. Lett., 4/3, 431-434	Bioorg. Med. Chem. Lett., 4/3, 431-434	Bioorg. Med. Chem. Lett., 4/3, 431-434	1994	Refereed	English	Research paper(scientific journal)	Disclose to all
K. Irie*, S. Kajiyama, S. Okuno, M. Kondo, K. Koshimizu, H. Hayashi, M. Arai, H. Nishino and A. Iwashima	K. Irie*, S. Kajiyama, S. Okuno, M. Kondo, K. Koshimizu, H. Hayashi, M. Arai, H. Nishino and A. Iwashima	K. Irie*, S. Kajiyama, S. Okuno, M. Kondo, K. Koshimizu, H. Hayashi, M. Arai, H. Nishino and A. Iwashima	New teleocidin-related metabolites, (-)-7-geranylindolactam-V and blastmycetin F, from Streptoverticillium blastmyceticum	New teleocidin-related metabolites, (-)-7-geranylindolactam-V and blastmycetin F, from Streptoverticillium blastmyceticum	New teleocidin-related metabolites, (-)-7-geranylindolactam-V and blastmycetin F, from Streptoverticillium blastmyceticum	J. Nat. Prod., 57/3, 363-368	J. Nat. Prod., 57/3, 363-368	J. Nat. Prod., 57/3, 363-368	1994	Refereed	English	Research paper(scientific journal)	Disclose to all
入江一浩	入江一浩		発癌プロモーター・テレオシジンの作用機構に関する有機化学的研究	発癌プロモーター・テレオシジンの作用機構に関する有機化学的研究		日本農芸化学会誌, 68/9, 1289-1296	日本農芸化学会誌, 68/9, 1289-1296		1994	Refereed	Japanese	Research paper(scientific journal)	Disclose to all
K. Irie*, S. Okuno, F. Koizumi and K. Koshimizu	K. Irie*, S. Okuno, F. Koizumi and K. Koshimizu	K. Irie*, S. Okuno, F. Koizumi and K. Koshimizu	Photolabile derivatives of indole alkaloid tumor promoter teleocidins : synthesis, biological activities and photoaffinity labeling studies	Photolabile derivatives of indole alkaloid tumor promoter teleocidins : synthesis, biological activities and photoaffinity labeling studies	Photolabile derivatives of indole alkaloid tumor promoter teleocidins : synthesis, biological activities and photoaffinity labeling studies	Tetrahedron, 49/47, 10817-10830	Tetrahedron, 49/47, 10817-10830	Tetrahedron, 49/47, 10817-10830	1993	Refereed	English	Research paper(scientific journal)	Disclose to all
T. Ando, K. Irie*, K. Koshimizu, T. Takemura, H. Nishino, A. Iwashima, N. Takeda, S. Nakajima and I. Sakata	T. Ando, K. Irie*, K. Koshimizu, T. Takemura, H. Nishino, A. Iwashima, N. Takeda, S. Nakajima and I. Sakata	T. Ando, K. Irie*, K. Koshimizu, T. Takemura, H. Nishino, A. Iwashima, N. Takeda, S. Nakajima and I. Sakata	Photocytotoxicity of water-soluble metalloporphyrin derivatives	Photocytotoxicity of water-soluble metalloporphyrin derivatives	Photocytotoxicity of water-soluble metalloporphyrin derivatives	Photochem. Photobiol., 57/4, 629-633	Photochem. Photobiol., 57/4, 629-633	Photochem. Photobiol., 57/4, 629-633	1993	Refereed	English	Research paper(scientific journal)	Disclose to all
P. A. Wender*, K. Irie and B. L. Miller	P. A. Wender*, K. Irie and B. L. Miller	P. A. Wender*, K. Irie and B. L. Miller	Synthesis and binding of photoaffinity ligand candidates for protein kinase C	Synthesis and binding of photoaffinity ligand candidates for protein kinase C	Synthesis and binding of photoaffinity ligand candidates for protein kinase C	J. Org. Chem., 58/16, 4179-4181	J. Org. Chem., 58/16, 4179-4181	J. Org. Chem., 58/16, 4179-4181	1993	Refereed	English	Research paper(scientific journal)	Disclose to all
K. Irie* and K. Koshimizu	K. Irie* and K. Koshimizu	K. Irie* and K. Koshimizu	Chemistry of indole alkaloid tumor promoter teleocidins	Chemistry of indole alkaloid tumor promoter teleocidins	Chemistry of indole alkaloid tumor promoter teleocidins	Comments Agric. & Food Chemistry,3/1, 1-25	Comments Agric. & Food Chemistry,3/1, 1-25	Comments Agric. & Food Chemistry,3/1, 1-25	1993	Refereed	English	Research paper(scientific journal)	Disclose to all
入江一浩*, 小清水弘一	入江一浩*, 小清水弘一		腫瘍親和性光増感剤ヘマトポルフィリン誘導体の活性成分は？	腫瘍親和性光増感剤ヘマトポルフィリン誘導体の活性成分は？		化学, 47/2, 142	化学, 47/2, 142		1992		Japanese	Research paper(scientific journal)	Disclose to all
S. Kajiyama, K. Irie*, T. Kido, K. Koshimizu, H. Hayashi and M.Arai	S. Kajiyama, K. Irie*, T. Kido, K. Koshimizu, H. Hayashi and M.Arai	S. Kajiyama, K. Irie*, T. Kido, K. Koshimizu, H. Hayashi and M.Arai	Synthesis of new indolactam analogues by microbial conversion	Synthesis of new indolactam analogues by microbial conversion	Synthesis of new indolactam analogues by microbial conversion	Tetrahedron, 47/29, 5453-5462	Tetrahedron, 47/29, 5453-5462	Tetrahedron, 47/29, 5453-5462	1991	Refereed	English	Research paper(scientific journal)	Disclose to all
K. Irie*, S. Okuno, S. Kajiyama, K. Koshimizu, H. Nishino and A. Iwashima	K. Irie*, S. Okuno, S. Kajiyama, K. Koshimizu, H. Nishino and A. Iwashima	K. Irie*, S. Okuno, S. Kajiyama, K. Koshimizu, H. Nishino and A. Iwashima	Quantitative structure-activity studies on indole alkaloid tumor promoter indolactam congeners	Quantitative structure-activity studies on indole alkaloid tumor promoter indolactam congeners	Quantitative structure-activity studies on indole alkaloid tumor promoter indolactam congeners	Carcinogenesis, 12/10, 1883-1886	Carcinogenesis, 12/10, 1883-1886	Carcinogenesis, 12/10, 1883-1886	1991	Refereed	English	Research paper(scientific journal)	Disclose to all
T. Ando, K. Irie*, K. Koshimizu, T. Shingu, N. Takeda, T. Takemura, S. Nakajima and I. Sakata	T. Ando, K. Irie*, K. Koshimizu, T. Shingu, N. Takeda, T. Takemura, S. Nakajima and I. Sakata	T. Ando, K. Irie*, K. Koshimizu, T. Shingu, N. Takeda, T. Takemura, S. Nakajima and I. Sakata	New photosensitizers for photodynamic therapy : syntheses of chlorin e6 dimer and trimer	New photosensitizers for photodynamic therapy : syntheses of chlorin e6 dimer and trimer	New photosensitizers for photodynamic therapy : syntheses of chlorin e6 dimer and trimer	Agric. Biol. Chem., 55/9, 2441-2443	Agric. Biol. Chem., 55/9, 2441-2443	Agric. Biol. Chem., 55/9, 2441-2443	1991	Refereed	English	Research paper(scientific journal)	Disclose to all
T. Ando, Y. Suzuki, R. Geka, K. Irie*, K. Koshimizu, T. Takemura, S. Nakajima and I. Sakata	T. Ando, Y. Suzuki, R. Geka, K. Irie*, K. Koshimizu, T. Takemura, S. Nakajima and I. Sakata	T. Ando, Y. Suzuki, R. Geka, K. Irie*, K. Koshimizu, T. Takemura, S. Nakajima and I. Sakata	New water-soluble pyropheophorbide a derivatives as possible agents for photodynamic therapy of cancer	New water-soluble pyropheophorbide a derivatives as possible agents for photodynamic therapy of cancer	New water-soluble pyropheophorbide a derivatives as possible agents for photodynamic therapy of cancer	Tetrahedron Lett., 32/38, 5107-5110	Tetrahedron Lett., 32/38, 5107-5110	Tetrahedron Lett., 32/38, 5107-5110	1991	Refereed	English	Research paper(scientific journal)	Disclose to all
入江一浩*, 小清水弘一	入江一浩*, 小清水弘一		発癌プロモーターの作用機作解明への有機化学的アプローチ	発癌プロモーターの作用機作解明への有機化学的アプローチ		有機合成化学協会誌, 49/11, 1070-1079	有機合成化学協会誌, 49/11, 1070-1079		1991	Refereed	Japanese	Research paper(scientific journal)	Disclose to all
K. Irie, S. Kajiyama, A. Funaki, K. Koshimizu*, H.Hayashi and M. Arai	K. Irie, S. Kajiyama, A. Funaki, K. Koshimizu*, H.Hayashi and M. Arai	K. Irie, S. Kajiyama, A. Funaki, K. Koshimizu*, H.Hayashi and M. Arai	Biosynthesis of (-)-indolactam V, the basic ring-structure of tumor poromoters teleocidins	Biosynthesis of (-)-indolactam V, the basic ring-structure of tumor poromoters teleocidins	Biosynthesis of (-)-indolactam V, the basic ring-structure of tumor poromoters teleocidins	Tetrahedron Lett., 31/1, 101-104	Tetrahedron Lett., 31/1, 101-104	Tetrahedron Lett., 31/1, 101-104	1990	Refereed	English	Research paper(scientific journal)	Disclose to all
K. Irie, S. Kajiyama, A. Funaki, K. Koshimizu*, H.Hayashi and M. Arai	K. Irie, S. Kajiyama, A. Funaki, K. Koshimizu*, H.Hayashi and M. Arai	K. Irie, S. Kajiyama, A. Funaki, K. Koshimizu*, H.Hayashi and M. Arai	Biosynthesis of indole alkaloid-tumor promoters teleocidins (I): possible biosynthetic pathway of the monoterpenoid moieties of teleocidins	Biosynthesis of indole alkaloid-tumor promoters teleocidins (I): possible biosynthetic pathway of the monoterpenoid moieties of teleocidins	Biosynthesis of indole alkaloid-tumor promoters teleocidins (I): possible biosynthetic pathway of the monoterpenoid moieties of teleocidins	Tetrahedron, 46/8, 2773-2788	Tetrahedron, 46/8, 2773-2788	Tetrahedron, 46/8, 2773-2788	1990	Refereed	English	Research paper(scientific journal)	Disclose to all
S. Okuno, K. Irie*, H. Nishino, A. Iwashima and K. Koshimizu	S. Okuno, K. Irie*, H. Nishino, A. Iwashima and K. Koshimizu	S. Okuno, K. Irie*, H. Nishino, A. Iwashima and K. Koshimizu	Syntheses and biological activities of photolabile indolactam derivatives; new probes for the receptor analysis of tumor promoters	Syntheses and biological activities of photolabile indolactam derivatives; new probes for the receptor analysis of tumor promoters	Syntheses and biological activities of photolabile indolactam derivatives; new probes for the receptor analysis of tumor promoters	Agric. Biol. Chem., 54/7, 1885-1887	Agric. Biol. Chem., 54/7, 1885-1887	Agric. Biol. Chem., 54/7, 1885-1887	1990	Refereed	English	Research paper(scientific journal)	Disclose to all
T. Kinoshita*, I. Takahashi, E. Kobayashi, T. Tamaoki, K. Irie, K. Koshimizu and T. Osato	T. Kinoshita*, I. Takahashi, E. Kobayashi, T. Tamaoki, K. Irie, K. Koshimizu and T. Osato	T. Kinoshita*, I. Takahashi, E. Kobayashi, T. Tamaoki, K. Irie, K. Koshimizu and T. Osato	Suppression by protein kinase C inhibitors of tumor promoter enhancement of Epstein-Barr virus-induced growth transformation	Suppression by protein kinase C inhibitors of tumor promoter enhancement of Epstein-Barr virus-induced growth transformation	Suppression by protein kinase C inhibitors of tumor promoter enhancement of Epstein-Barr virus-induced growth transformation	Anticancer Res., 10/4, 1051-1054	Anticancer Res., 10/4, 1051-1054	Anticancer Res., 10/4, 1051-1054	1990	Refereed	English	Research paper(scientific journal)	Disclose to all
K. Irie*, S. Kajiyama, K. Koshimizu, H. Hayashi and M.Arai	K. Irie*, S. Kajiyama, K. Koshimizu, H. Hayashi and M.Arai	K. Irie*, S. Kajiyama, K. Koshimizu, H. Hayashi and M.Arai	Isolation and biosynthesis of (-)-indolactam I, a new congener of indole alkaloid tumor promoter teleocidins	Isolation and biosynthesis of (-)-indolactam I, a new congener of indole alkaloid tumor promoter teleocidins	Isolation and biosynthesis of (-)-indolactam I, a new congener of indole alkaloid tumor promoter teleocidins	Tetrahedron Lett., 31/50, 7337-7340	Tetrahedron Lett., 31/50, 7337-7340	Tetrahedron Lett., 31/50, 7337-7340	1990	Refereed	English	Research paper(scientific journal)	Disclose to all
T. Ando, K. Irie*, K. Koshimizu, T. Takemura, H. Nishino, A. Iwashima, S. Nakajima and I. Sakata	T. Ando, K. Irie*, K. Koshimizu, T. Takemura, H. Nishino, A. Iwashima, S. Nakajima and I. Sakata	T. Ando, K. Irie*, K. Koshimizu, T. Takemura, H. Nishino, A. Iwashima, S. Nakajima and I. Sakata	Synthesis, physicochemical properties and photocytotoxicity of five new δ-substituted chlorin e6 derivatives	Synthesis, physicochemical properties and photocytotoxicity of five new δ-substituted chlorin e6 derivatives	Synthesis, physicochemical properties and photocytotoxicity of five new δ-substituted chlorin e6 derivatives	Tetrahedron, 46/17, 5921-5930	Tetrahedron, 46/17, 5921-5930	Tetrahedron, 46/17, 5921-5930	1990	Refereed	English	Research paper(scientific journal)	Disclose to all
K. Irie, S. Okuno, K. Koshimizu*, H. Tokuda, H. Nishino and A. Iwashima	K. Irie, S. Okuno, K. Koshimizu*, H. Tokuda, H. Nishino and A. Iwashima	K. Irie, S. Okuno, K. Koshimizu*, H. Tokuda, H. Nishino and A. Iwashima	Biological activities and cellular uptake studies of fluorescent derivatives of indole alkaloid tumor promoter teleocidin	Biological activities and cellular uptake studies of fluorescent derivatives of indole alkaloid tumor promoter teleocidin	Biological activities and cellular uptake studies of fluorescent derivatives of indole alkaloid tumor promoter teleocidin	Int. J. Cancer, 43/3, 513-519	Int. J. Cancer, 43/3, 513-519	Int. J. Cancer, 43/3, 513-519	1989	Refereed	English	Research paper(scientific journal)	Disclose to all
K. Irie, A. Funaki, K. Koshimizu*, H. Hayashi and M. Arai	K. Irie, A. Funaki, K. Koshimizu*, H. Hayashi and M. Arai	K. Irie, A. Funaki, K. Koshimizu*, H. Hayashi and M. Arai	Structure of blastmycetin E, a new teleocidin-related compound, from Streptoverticillium blastmyceticum	Structure of blastmycetin E, a new teleocidin-related compound, from Streptoverticillium blastmyceticum	Structure of blastmycetin E, a new teleocidin-related compound, from Streptoverticillium blastmyceticum	Tetrahedron Lett., 30/16, 2113-2116	Tetrahedron Lett., 30/16, 2113-2116	Tetrahedron Lett., 30/16, 2113-2116	1989	Refereed	English	Research paper(scientific journal)	Disclose to all
K. Koshimizu* and K. Irie	K. Koshimizu* and K. Irie	K. Koshimizu* and K. Irie	Structure-activity studies in the induction of Epstein-Barr virus by the indole alkaloid tumor promoter teleocidins	Structure-activity studies in the induction of Epstein-Barr virus by the indole alkaloid tumor promoter teleocidins	Structure-activity studies in the induction of Epstein-Barr virus by the indole alkaloid tumor promoter teleocidins	Hokkaido Univ. Med. Lib. Ser., 24, 111-134	Hokkaido Univ. Med. Lib. Ser., 24, 111-134	Hokkaido Univ. Med. Lib. Ser., 24, 111-134	1989	Refereed	English	Research paper(scientific journal)	Disclose to all
N. Hagiwara, K. Irie, A. Funaki, H. Hayashi, M. Arai and K. Koshimizu*	N. Hagiwara, K. Irie, A. Funaki, H. Hayashi, M. Arai and K. Koshimizu*	N. Hagiwara, K. Irie, A. Funaki, H. Hayashi, M. Arai and K. Koshimizu*	Structure and tumor-promoting activity of new teleocidin-related metabolites (blastmycetins) from Streptoverticillium blastmyceticum	Structure and tumor-promoting activity of new teleocidin-related metabolites (blastmycetins) from Streptoverticillium blastmyceticum	Structure and tumor-promoting activity of new teleocidin-related metabolites (blastmycetins) from Streptoverticillium blastmyceticum	Agric. Biol. Chem., 52/3, 641-648	Agric. Biol. Chem., 52/3, 641-648	Agric. Biol. Chem., 52/3, 641-648	1988	Refereed	English	Research paper(scientific journal)	Disclose to all
K. Irie and K. Koshimizu*	K. Irie and K. Koshimizu*	K. Irie and K. Koshimizu*	Structure-activity studies of indole alkaloid tumor promoters	Structure-activity studies of indole alkaloid tumor promoters	Structure-activity studies of indole alkaloid tumor promoters	Mem. Coll. Agric., Kyoto Univ.,132, 1-59	Mem. Coll. Agric., Kyoto Univ.,132, 1-59	Mem. Coll. Agric., Kyoto Univ.,132, 1-59	1988	Refereed	English	Research paper(scientific journal)	Disclose to all
K. Irie, N. Hagiwara, A. Funaki, H. Hayashi, M. Arai, H. Tokuda and K. Koshimizu*	K. Irie, N. Hagiwara, A. Funaki, H. Hayashi, M. Arai, H. Tokuda and K. Koshimizu*	K. Irie, N. Hagiwara, A. Funaki, H. Hayashi, M. Arai, H. Tokuda and K. Koshimizu*	Isolation and biological activities of N13-desmethyl analogues of tumor promoter teleocidin from Streptoverticillium blastmyceticum	Isolation and biological activities of N13-desmethyl analogues of tumor promoter teleocidin from Streptoverticillium blastmyceticum	Isolation and biological activities of N13-desmethyl analogues of tumor promoter teleocidin from Streptoverticillium blastmyceticum	Agric. Biol. Chem., 52/12, 3193-3195	Agric. Biol. Chem., 52/12, 3193-3195	Agric. Biol. Chem., 52/12, 3193-3195	1988	Refereed	English	Research paper(scientific journal)	Disclose to all
Y. Nakagawa*, T. Sotomatsu, K. Irie, K. Kitahara, H. Iwamura and T. Fujita	Y. Nakagawa*, T. Sotomatsu, K. Irie, K. Kitahara, H. Iwamura and T. Fujita	Y. Nakagawa*, T. Sotomatsu, K. Irie, K. Kitahara, H. Iwamura and T. Fujita	Quantitative structure-activity studies of benzoylphenylurea larvicides	Quantitative structure-activity studies of benzoylphenylurea larvicides	Quantitative structure-activity studies of benzoylphenylurea larvicides	Pestic. Biochem. Physiol.,27, 143-155	Pestic. Biochem. Physiol.,27, 143-155	Pestic. Biochem. Physiol.,27, 143-155	1987	Refereed	English	Research paper(scientific journal)	Disclose to all
入江一浩	入江一浩		Teleocidin 類の構造活性相関と蛍光標識化	Teleocidin 類の構造活性相関と蛍光標識化		日本農芸化学会誌, 61/7, 830-833	日本農芸化学会誌, 61/7, 830-833		1987	Refereed	Japanese	Research paper(scientific journal)	Disclose to all
K. Irie, N. Hagiwara, T. Kurome, H. Hayashi, M. Arai and K. Koshimizu*	K. Irie, N. Hagiwara, T. Kurome, H. Hayashi, M. Arai and K. Koshimizu*	K. Irie, N. Hagiwara, T. Kurome, H. Hayashi, M. Arai and K. Koshimizu*	New teleocidin-related metabolites from Streptoverticillium blastmycericum producing tumor-promoting indole alkaloids	New teleocidin-related metabolites from Streptoverticillium blastmycericum producing tumor-promoting indole alkaloids	New teleocidin-related metabolites from Streptoverticillium blastmycericum producing tumor-promoting indole alkaloids	Agric. Biol. Chem., 51/1, 285-287	Agric. Biol. Chem., 51/1, 285-287	Agric. Biol. Chem., 51/1, 285-287	1987	Refereed	English	Research paper(scientific journal)	Disclose to all
K. Irie, N. Hagiwara, H. Tokuda and K. Koshimizu*	K. Irie, N. Hagiwara, H. Tokuda and K. Koshimizu*	K. Irie, N. Hagiwara, H. Tokuda and K. Koshimizu*	Structure-activity studies of the indole alkaloid tumor promoter teleocidins	Structure-activity studies of the indole alkaloid tumor promoter teleocidins	Structure-activity studies of the indole alkaloid tumor promoter teleocidins	Carcinogenesis, 8/4, 547-552	Carcinogenesis, 8/4, 547-552	Carcinogenesis, 8/4, 547-552	1987	Refereed	English	Research paper(scientific journal)	Disclose to all
K. Irie, N. Hagiwara, A. Funaki, H. Hayashi, M. Arai and K. Koshimizu*	K. Irie, N. Hagiwara, A. Funaki, H. Hayashi, M. Arai and K. Koshimizu*	K. Irie, N. Hagiwara, A. Funaki, H. Hayashi, M. Arai and K. Koshimizu*	Isolation of blastmycetin D, a possible precursor of teleocidins, from Streptoverticillium blastmyceticum	Isolation of blastmycetin D, a possible precursor of teleocidins, from Streptoverticillium blastmyceticum	Isolation of blastmycetin D, a possible precursor of teleocidins, from Streptoverticillium blastmyceticum	Agric. Biol. Chem., 51/6, 1733-1735	Agric. Biol. Chem., 51/6, 1733-1735	Agric. Biol. Chem., 51/6, 1733-1735	1987	Refereed	English	Research paper(scientific journal)	Disclose to all
K. Irie, N. Hagiwara and K. Koshimizu*	K. Irie, N. Hagiwara and K. Koshimizu*	K. Irie, N. Hagiwara and K. Koshimizu*	Synthesis of a biologically active fluorescent indolactam derivative; a method of preparing new probes for receptor analysis of tumor promoters	Synthesis of a biologically active fluorescent indolactam derivative; a method of preparing new probes for receptor analysis of tumor promoters	Synthesis of a biologically active fluorescent indolactam derivative; a method of preparing new probes for receptor analysis of tumor promoters	Tetrahedron Lett., 28/28, 3267-3270	Tetrahedron Lett., 28/28, 3267-3270	Tetrahedron Lett., 28/28, 3267-3270	1987	Refereed	English	Research paper(scientific journal)	Disclose to all
N. Hagiwara, K. Irie, H. Tokuda and K. Koshimizu*	N. Hagiwara, K. Irie, H. Tokuda and K. Koshimizu*	N. Hagiwara, K. Irie, H. Tokuda and K. Koshimizu*	The metabolism of indole alkaloid tumor promoter, (-)-indolactam V, which has the fundamental structure of teleocidins, by rat liver microsomes	The metabolism of indole alkaloid tumor promoter, (-)-indolactam V, which has the fundamental structure of teleocidins, by rat liver microsomes	The metabolism of indole alkaloid tumor promoter, (-)-indolactam V, which has the fundamental structure of teleocidins, by rat liver microsomes	Carcinogenesis, 8/7, 963-965	Carcinogenesis, 8/7, 963-965	Carcinogenesis, 8/7, 963-965	1987	Refereed	English	Research paper(scientific journal)	Disclose to all
K. Irie, N. Hagiwara and K. Koshimizu*	K. Irie, N. Hagiwara and K. Koshimizu*	K. Irie, N. Hagiwara and K. Koshimizu*	New probes for receptor analysis of tumor promoters synthesis of fluorescent derivatives of (-)-indolactam V, the basic ring-structure of teleocidins	New probes for receptor analysis of tumor promoters synthesis of fluorescent derivatives of (-)-indolactam V, the basic ring-structure of teleocidins	New probes for receptor analysis of tumor promoters synthesis of fluorescent derivatives of (-)-indolactam V, the basic ring-structure of teleocidins	Tetrahedron, 43/22, 5251-5260	Tetrahedron, 43/22, 5251-5260	Tetrahedron, 43/22, 5251-5260	1987	Refereed	English	Research paper(scientific journal)	Disclose to all
K. Irie, H. Hayashi, M. Arai and K. Koshimizu*	K. Irie, H. Hayashi, M. Arai and K. Koshimizu*	K. Irie, H. Hayashi, M. Arai and K. Koshimizu*	Substitution reaction on the indole ring of (-)-indolactam V, the fundamental structure of teleocidins	Substitution reaction on the indole ring of (-)-indolactam V, the fundamental structure of teleocidins	Substitution reaction on the indole ring of (-)-indolactam V, the fundamental structure of teleocidins	Agric. Biol. Chem., 50/10, 2679-2680	Agric. Biol. Chem., 50/10, 2679-2680	Agric. Biol. Chem., 50/10, 2679-2680	1986	Refereed	English	Research paper(scientific journal)	Disclose to all
入江一浩*, 小清水弘一	入江一浩*, 小清水弘一		微生物の生産する発癌プロモーター	微生物の生産する発癌プロモーター		日本放線菌学会誌,49, 3-9	日本放線菌学会誌,49, 3-9		1986	Refereed	Japanese	Research paper(scientific journal)	Disclose to all
K. Irie, N. Hagiwara, K. Koshimizu*, H. Hayashi, S. Murao, H. Tokuda and Y. Ito	K. Irie, N. Hagiwara, K. Koshimizu*, H. Hayashi, S. Murao, H. Tokuda and Y. Ito	K. Irie, N. Hagiwara, K. Koshimizu*, H. Hayashi, S. Murao, H. Tokuda and Y. Ito	Isolation and the Epstein-Barr virus early antigen inducing activity of olivoretins from Streptoverticillium blastmyceticum	Isolation and the Epstein-Barr virus early antigen inducing activity of olivoretins from Streptoverticillium blastmyceticum	Isolation and the Epstein-Barr virus early antigen inducing activity of olivoretins from Streptoverticillium blastmyceticum	Agric. Biol. Chem., 49/1, 221-223	Agric. Biol. Chem., 49/1, 221-223	Agric. Biol. Chem., 49/1, 221-223	1985	Refereed	English	Research paper(scientific journal)	Disclose to all
K. Irie*, N. Hagiwara, K. Koshimizu, H. Hayashi, S. Murao and Y. Ito	K. Irie*, N. Hagiwara, K. Koshimizu, H. Hayashi, S. Murao and Y. Ito	K. Irie*, N. Hagiwara, K. Koshimizu, H. Hayashi, S. Murao and Y. Ito	Identification of the microorganism which produces Epstein-Barr virus early antigen-inducing indole alkaloids	Identification of the microorganism which produces Epstein-Barr virus early antigen-inducing indole alkaloids	Identification of the microorganism which produces Epstein-Barr virus early antigen-inducing indole alkaloids	Agric. Biol. Chem., 49/3, 845-847	Agric. Biol. Chem., 49/3, 845-847	Agric. Biol. Chem., 49/3, 845-847	1985	Refereed	English	Research paper(scientific journal)	Disclose to all
H. Fujiki*, M. Suganuma, H. Hakii, M. Nakayasu, Y. Endo, K. Shodo, K. Irie, K. Koshimizu and T. Sugimura, M. J. A.	H. Fujiki*, M. Suganuma, H. Hakii, M. Nakayasu, Y. Endo, K. Shodo, K. Irie, K. Koshimizu and T. Sugimura, M. J. A.	H. Fujiki*, M. Suganuma, H. Hakii, M. Nakayasu, Y. Endo, K. Shodo, K. Irie, K. Koshimizu and T. Sugimura, M. J. A.	Tumor promoting activities of new synthetic analogues of teleocidin	Tumor promoting activities of new synthetic analogues of teleocidin	Tumor promoting activities of new synthetic analogues of teleocidin	Proc. Japan Acad., 61/1, 45-47	Proc. Japan Acad., 61/1, 45-47	Proc. Japan Acad., 61/1, 45-47	1985	Refereed	English	Research paper(scientific journal)	Disclose to all
K. Irie, N. Hagiwara, K. Koshimizu*, H. Tokuda, Y. Ito, H. Hayashi, and S. Murao	K. Irie, N. Hagiwara, K. Koshimizu*, H. Tokuda, Y. Ito, H. Hayashi, and S. Murao	K. Irie, N. Hagiwara, K. Koshimizu*, H. Tokuda, Y. Ito, H. Hayashi, and S. Murao	Epstein-Barr Virus Early Antigen Inducing Activity of 14-O-Derivatives of (-)-Indolactam V	Epstein-Barr Virus Early Antigen Inducing Activity of 14-O-Derivatives of (-)-Indolactam V	Epstein-Barr Virus Early Antigen Inducing Activity of 14-O-Derivatives of (-)-Indolactam V	Agric. Biol. Chem., 49/5, 1441-1446	Agric. Biol. Chem., 49/5, 1441-1446	Agric. Biol. Chem., 49/5, 1441-1446	1985	Refereed	English	Research paper(scientific journal)	Disclose to all
N. Hagiwara, K. Irie, K. Koshimizu*, H. Hayashi, S. Murao, H. Tokuda and Y. Ito	N. Hagiwara, K. Irie, K. Koshimizu*, H. Hayashi, S. Murao, H. Tokuda and Y. Ito	N. Hagiwara, K. Irie, K. Koshimizu*, H. Hayashi, S. Murao, H. Tokuda and Y. Ito	New teleocidin metabolites from Streptoverticillium blastmyceticum	New teleocidin metabolites from Streptoverticillium blastmyceticum	New teleocidin metabolites from Streptoverticillium blastmyceticum	Agric. Biol. Chem., 49/8, 2529-2530	Agric. Biol. Chem., 49/8, 2529-2530	Agric. Biol. Chem., 49/8, 2529-2530	1985	Refereed	English	Research paper(scientific journal)	Disclose to all
K. Irie, H. Tokuda, N. Hagiwara, K. Koshimizu*, H. Hayashi, S. Murao and Y. Ito	K. Irie, H. Tokuda, N. Hagiwara, K. Koshimizu*, H. Hayashi, S. Murao and Y. Ito	K. Irie, H. Tokuda, N. Hagiwara, K. Koshimizu*, H. Hayashi, S. Murao and Y. Ito	Structure-activity relationship in the induction of Epstein-Barr virus by teleocidin derivatives	Structure-activity relationship in the induction of Epstein-Barr virus by teleocidin derivatives	Structure-activity relationship in the induction of Epstein-Barr virus by teleocidin derivatives	Int. J. Cancer, 36/4, 485-488	Int. J. Cancer, 36/4, 485-488	Int. J. Cancer, 36/4, 485-488	1985	Refereed	English	Research paper(scientific journal)	Disclose to all
K. Irie, M. Hirota, N. Hagiwara, K. Koshimizu*, H. Hayashi, S. Murao, H. Tokuda, and Y. Ito	K. Irie, M. Hirota, N. Hagiwara, K. Koshimizu*, H. Hayashi, S. Murao, H. Tokuda, and Y. Ito	K. Irie, M. Hirota, N. Hagiwara, K. Koshimizu*, H. Hayashi, S. Murao, H. Tokuda, and Y. Ito	The Epstein-Barr virus early antigen inducing indole alkaloids, (-)-indolactam V and its related compounds produced by actinomycetes	The Epstein-Barr virus early antigen inducing indole alkaloids, (-)-indolactam V and its related compounds produced by actinomycetes	The Epstein-Barr virus early antigen inducing indole alkaloids, (-)-indolactam V and its related compounds produced by actinomycetes	Agric. Biol. Chem., 48/5, 1269-1274	Agric. Biol. Chem., 48/5, 1269-1274	Agric. Biol. Chem., 48/5, 1269-1274	1984	Refereed	English	Research paper(scientific journal)	Disclose to all
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Author	Author(Japanese)	Author(English)	Title	Title(Japanese)	Title(English)	Bibliography	Bibliography(Japanese)	Bibliography(English)	Publication date	Refereed paper	Language	Publishing type	Disclose
Y. Ashida et al.	Y. Ashida et al.	Y. Ashida et al.	Synthesis, conformation, and biological activities of a des-A-ring analog of 18-deoxy-aplog-1, a simplified analog of debromoaplysiatoxin	Synthesis, conformation, and biological activities of a des-A-ring analog of 18-deoxy-aplog-1, a simplified analog of debromoaplysiatoxin	Synthesis, conformation, and biological activities of a des-A-ring analog of 18-deoxy-aplog-1, a simplified analog of debromoaplysiatoxin	新学術領域研究「化学コミュニケーションのフロンティア」第1回国際シンポジウム (ISCC2019)、（一橋大学一橋講堂、東京）	新学術領域研究「化学コミュニケーションのフロンティア」第1回国際シンポジウム (ISCC2019)（一橋大学一橋講堂、東京）	新学術領域研究「化学コミュニケーションのフロンティア」第1回国際シンポジウム (ISCC2019)、（一橋大学一橋講堂、東京）	2019/01		English	Summary of the papers read (international conference)	Disclose to all
M. Yoshimura et al.	M. Yoshimura et al.	M. Yoshimura et al.	Evaluation system of amyloid beta precursor protein processing in rat primary cortical neurons treated with PKC activators	Evaluation system of amyloid beta precursor protein processing in rat primary cortical neurons treated with PKC activators	Evaluation system of amyloid beta precursor protein processing in rat primary cortical neurons treated with PKC activators	新学術領域研究「化学コミュニケーションのフロンティア」第1回国際シンポジウム (ISCC2019)（一橋大学一橋講堂、東京）	新学術領域研究「化学コミュニケーションのフロンティア」第1回国際シンポジウム (ISCC2019)（一橋大学一橋講堂、東京）	新学術領域研究「化学コミュニケーションのフロンティア」第1回国際シンポジウム (ISCC2019)（一橋大学一橋講堂、東京）	2019/01		English	Summary of the papers read (international conference)	Disclose to all
片岡翔太郎　他	片岡翔太郎　他	片岡翔太郎　他	Aβ42毒性オリゴマーの細胞内標的タンパク質と作用機序	Aβ42毒性オリゴマーの細胞内標的タンパク質と作用機序	Aβ42毒性オリゴマーの細胞内標的タンパク質と作用機序	日本農芸化学会2018年度関西支部例会（第506回講演会）（神戸大学、神戸市）	日本農芸化学会2018年度関西支部例会（第506回講演会）（神戸大学、神戸市）	日本農芸化学会2018年度関西支部例会（第506回講演会）（神戸大学、神戸市）	2018/12		Japanese	Summary of the papers read (national conference and other science council)	Disclose to all
K. Murakami et al.	K. Murakami et al.	K. Murakami et al.	RNA aptamers targeting the toxic oligomers of Aβ42 and their application to immunohistochemistry	RNA aptamers targeting the toxic oligomers of Aβ42 and their application to immunohistochemistry	RNA aptamers targeting the toxic oligomers of Aβ42 and their application to immunohistochemistry	The 45th International Syposium on Nucleic Acids Chemistry (Kyoto University Clock Tower Centennial Hall) (Kyoto, Japan)	The 45th International Syposium on Nucleic Acids Chemistry (Kyoto University Clock Tower Centennial Hall) (Kyoto, Japan)	The 45th International Syposium on Nucleic Acids Chemistry (Kyoto University Clock Tower Centennial Hall) (Kyoto, Japan)	2018/11		English	Summary of the papers read (international conference)	Disclose to all
塚田健人　他	塚田健人　他	塚田健人　他	生合成経路の再構築と再設計による糸状菌ジテルペノイドピロンライブラリーの構築と生物活性評価	生合成経路の再構築と再設計による糸状菌ジテルペノイドピロンライブラリーの構築と生物活性評価	生合成経路の再構築と再設計による糸状菌ジテルペノイドピロンライブラリーの構築と生物活性評価	第36回メディシナルケミストリーシンポジウム（京都テルサ、京都市）	第36回メディシナルケミストリーシンポジウム（京都テルサ、京都市）	第36回メディシナルケミストリーシンポジウム（京都テルサ、京都市）	2018/11		Japanese	Summary of the papers read (national conference and other science council)	Disclose to all
Y. Hanaki et al.	Y. Hanaki et al.	Y. Hanaki et al.	Synthetic studies on oscillatoxin D and its analogs	Synthetic studies on oscillatoxin D and its analogs	Synthetic studies on oscillatoxin D and its analogs	The 14th International Kyoto Conference on New Aspects of Organic Chemistry (Rihga Royal Hotel) (Kyoto, Japan)	The 14th International Kyoto Conference on New Aspects of Organic Chemistry (Rihga Royal Hotel) (Kyoto, Japan)	The 14th International Kyoto Conference on New Aspects of Organic Chemistry (Rihga Royal Hotel) (Kyoto, Japan)	2018/11		English	Summary of the papers read (international conference)	Disclose to all
冨所康志　他	冨所康志　他	冨所康志　他	脳脊髄液中のAβ毒性コンホマー量とタウの関連	脳脊髄液中のAβ毒性コンホマー量とタウの関連	脳脊髄液中のAβ毒性コンホマー量とタウの関連	第37回日本認知症学会学術集会（ロイトン札幌・札幌市教育文化会館、札幌市）	第37回日本認知症学会学術集会（ロイトン札幌・札幌市教育文化会館、札幌市））	第37回日本認知症学会学術集会（ロイトン札幌・札幌市教育文化会館、札幌市）	2018/10		Japanese	Summary of the papers read (national conference and other science council)	Disclose to all
鷲崎彩夏　他	鷲崎彩夏　他	鷲崎彩夏　他	新規PKC活性化薬の10-Methyl-Aplog-1はJQ1との併用により理想的なLatency Reversing Agentとしての活性を示す	新規PKC活性化薬の10-Methyl-Aplog-1はJQ1との併用により理想的なLatency Reversing Agentとしての活性を示す	新規PKC活性化薬の10-Methyl-Aplog-1はJQ1との併用により理想的なLatency Reversing Agentとしての活性を示す	第66回日本ウイルス学会学術集会（京都テルサ、京都市）	第66回日本ウイルス学会学術集会（京都テルサ、京都市）	第66回日本ウイルス学会学術集会（京都テルサ、京都市）	2018/10		Japanese	Summary of the papers read (national conference and other science council)	Disclose to all
松島由佳　他	松島由佳　他	松島由佳　他	分子内ジスルフィド結合形成によるアミロイドβの毒性コンホメーションの制御	分子内ジスルフィド結合形成によるアミロイドβの毒性コンホメーションの制御	分子内ジスルフィド結合形成によるアミロイドβの毒性コンホメーションの制御	第37回日本認知症学会学術集会（ロイトン札幌・札幌市教育文化会館、札幌市）	第37回日本認知症学会学術集会（ロイトン札幌・札幌市教育文化会館、札幌市）	第37回日本認知症学会学術集会（ロイトン札幌・札幌市教育文化会館、札幌市）	2018/10		Japanese	Summary of the papers read (national conference and other science council)	Disclose to all
村上一馬　他	村上一馬　他	村上一馬　他	天然物によるアミロイドβの毒性オリゴマー形成阻害機構	天然物によるアミロイドβの毒性オリゴマー形成阻害機構	天然物によるアミロイドβの毒性オリゴマー形成阻害機構	第37回日本認知症学会学術集会（ロイトン札幌・札幌市教育文化会館、札幌市）	第37回日本認知症学会学術集会（ロイトン札幌・札幌市教育文化会館、札幌市））	第37回日本認知症学会学術集会（ロイトン札幌・札幌市教育文化会館、札幌市）	2018/10		Japanese	Summary of the papers read (national conference and other science council)	Disclose to all
早川皓太郎　他	早川皓太郎　他	早川皓太郎　他	抗腫瘍性Aplysiatoxin単純化アナログ・10-Me-Aplog-1のアセタール型アナログの合成と生物活性	抗腫瘍性Aplysiatoxin単純化アナログ・10-Me-Aplog-1のアセタール型アナログの合成と生物活性	抗腫瘍性Aplysiatoxin単純化アナログ・10-Me-Aplog-1のアセタール型アナログの合成と生物活性	第60回天然有機化合物討論会、久留米シティープラザ（福岡県久留米市）	第60回天然有機化合物討論会（久留米シティープラザ、福岡県久留米市）	第60回天然有機化合物討論会、久留米シティープラザ（福岡県久留米市）	2018/09	Refereed	Japanese	Summary of the papers read (national conference and other science council)	Disclose to all
植松紗和子　他	植松紗和子　他	植松紗和子　他	サンゴジュに含まれるビブサニン類のプロテインキナーゼC結合活性の評価と結合様式の予測	サンゴジュに含まれるビブサニン類のプロテインキナーゼC結合活性の評価と結合様式の予測	サンゴジュに含まれるビブサニン類のプロテインキナーゼC結合活性の評価と結合様式の予測	日本農芸化学会2018年度中四国支部大会（島根大学松江キャンパス、松江市）	日本農芸化学会2018年度中四国支部大会（島根大学松江キャンパス、松江市）	日本農芸化学会2018年度中四国支部大会（島根大学松江キャンパス、松江市）	2018/09		Japanese	Summary of the papers read (national conference and other science council)	Disclose to all
小畑弥生　他	小畑弥生　他	小畑弥生　他	アミロイドβ42の2量体モデル由来の毒性オリゴマーに対するRNAアプタマー	アミロイドβ42の2量体モデル由来の毒性オリゴマーに対するRNAアプタマー	アミロイドβ42の2量体モデル由来の毒性オリゴマーに対するRNAアプタマー	日本核酸医薬学会第4回年会（九州大学医学部百年講堂、福岡市）	日本核酸医薬学会第4回年会（九州大学医学部百年講堂、福岡市）	日本核酸医薬学会第4回年会（九州大学医学部百年講堂、福岡市）	2018/07		Japanese	Summary of the papers read (national conference and other science council)	Disclose to all
鷲崎彩夏　他	鷲崎彩夏　他	鷲崎彩夏　他	新規PKC活性化薬の10-Methyl-Aplog-1はJQ1との併用により理想的なLatency Reversing Agentとしての活性を示す	新規PKC活性化薬の10-Methyl-Aplog-1はJQ1との併用により理想的なLatency Reversing Agentとしての活性を示す	新規PKC活性化薬の10-Methyl-Aplog-1はJQ1との併用により理想的なLatency Reversing Agentとしての活性を示す	第32回近畿エイズ研究会学術集会（大阪大学微生物病研究所、吹田市）	第32回近畿エイズ研究会学術集会（大阪大学微生物病研究所、吹田市）	第32回近畿エイズ研究会学術集会（大阪大学微生物病研究所、吹田市）	2018/06		Japanese	Summary of the papers read (national conference and other science council)	Disclose to all
冨所康志　他	冨所康志　他	冨所康志　他	Toxic Aβ conformer and tau in CSF obtained from the cases of AD dementia, a preliminary study	Toxic Aβ conformer and tau in CSF obtained from the cases of AD dementia, a preliminary study	Toxic Aβ conformer and tau in CSF obtained from the cases of AD dementia, a preliminary study	第59回日本神経学会学術大会（札幌市教育文化会館、札幌市）	第59回日本神経学会学術大会（札幌市教育文化会館、札幌市）	第59回日本神経学会学術大会（札幌市教育文化会館、札幌市）	2018/05		Japanese	Summary of the papers read (national conference and other science council)	Disclose to all
花木祐輔　他	花木祐輔　他	花木祐輔　他	Aplysiatoxin 単純化アナログ・10-Methyl-aplog-1のがん細胞増殖抑制に関わるPKCアイソザイムの同定	Aplysiatoxin 単純化アナログ・10-Methyl-aplog-1のがん細胞増殖抑制に関わるPKCアイソザイムの同定	Aplysiatoxin 単純化アナログ・10-Methyl-aplog-1のがん細胞増殖抑制に関わるPKCアイソザイムの同定	2018年度日本農芸化学会大会（名城大学、名古屋市）	2018年度日本農芸化学会大会（名城大学、名古屋市）	2018年度日本農芸化学会大会（名城大学、名古屋市）	2018/03		Japanese	Summary of the papers read (national conference and other science council)	Disclose to all
花木瑞穂　他	花木瑞穂　他	花木瑞穂　他	アポモルフィンによるアミロイドβ42凝集抑制機構の解析	アポモルフィンによるアミロイドβ42凝集抑制機構の解析	アポモルフィンによるアミロイドβ42凝集抑制機構の解析	2018年度日本農芸化学会大会（名城大学、名古屋市）	2018年度日本農芸化学会大会（名城大学、名古屋市）	2018年度日本農芸化学会大会（名城大学、名古屋市）	2018/03		Japanese	Summary of the papers read (national conference and other science council)	Disclose to all
片岡翔太郎　他	片岡翔太郎　他	片岡翔太郎　他	アミロイドβ42の毒性オリゴマーの細胞内標的探索	アミロイドβ42の毒性オリゴマーの細胞内標的探索	アミロイドβ42の毒性オリゴマーの細胞内標的探索	2018年度日本農芸化学会大会（名城大学、名古屋市）	2018年度日本農芸化学会大会（名城大学、名古屋市）	2018年度日本農芸化学会大会（名城大学、名古屋市）	2018/03		Japanese	Summary of the papers read (national conference and other science council)	Disclose to all
小畑弥生　他	小畑弥生　他	小畑弥生　他	アミロイドβ42の毒性2量体モデルから形成されるプロトフィブリルを標的としたRNAアプタマーの開発	アミロイドβ42の毒性2量体モデルから形成されるプロトフィブリルを標的としたRNAアプタマーの開発	アミロイドβ42の毒性2量体モデルから形成されるプロトフィブリルを標的としたRNAアプタマーの開発	2018年度日本農芸化学会大会（名城大学、名古屋市）	2018年度日本農芸化学会大会（名城大学、名古屋市）	2018年度日本農芸化学会大会（名城大学、名古屋市）	2018/03		Japanese	Summary of the papers read (national conference and other science council)	Disclose to all
早川皓太郎　他	早川皓太郎　他	早川皓太郎　他	アプリシアトキシン単純化アナログ・10-Me-Aplog-1の3位アセタール型アナログの合成	アプリシアトキシン単純化アナログ・10-Me-Aplog-1の3位アセタール型アナログの合成	アプリシアトキシン単純化アナログ・10-Me-Aplog-1の3位アセタール型アナログの合成	2018年度日本農芸化学会大会（名城大学、名古屋市）	2018年度日本農芸化学会大会（名城大学、名古屋市）	2018年度日本農芸化学会大会（名城大学、名古屋市）	2018/03		Japanese	Summary of the papers read (national conference and other science council)	Disclose to all
高田晃児　他	高田晃児　他	高田晃児　他	アプリシアトキシン単純化アナログ・10-Me-aplog-1の側鎖誘導体の合成と活性	アプリシアトキシン単純化アナログ・10-Me-aplog-1の側鎖誘導体の合成と活性	アプリシアトキシン単純化アナログ・10-Me-aplog-1の側鎖誘導体の合成と活性	2018年度日本農芸化学会大会（名城大学、名古屋市）	2018年度日本農芸化学会大会（名城大学、名古屋市）	2018年度日本農芸化学会大会（名城大学、名古屋市）	2018/03		Japanese	Summary of the papers read (national conference and other science council)	Disclose to all
坂口嘉紀　他	坂口嘉紀　他	坂口嘉紀　他	青ジソに含まれるアミロイドβ42の凝集阻害物質の作用機構とマウスにおける生体内代謝	青ジソに含まれるアミロイドβ42の凝集阻害物質の作用機構とマウスにおける生体内代謝	青ジソに含まれるアミロイドβ42の凝集阻害物質の作用機構とマウスにおける生体内代謝	2018年度日本農芸化学会大会（名城大学、名古屋市）	2018年度日本農芸化学会大会（名城大学、名古屋市）	2018年度日本農芸化学会大会（名城大学、名古屋市）	2018/03		Japanese	Summary of the papers read (national conference and other science council)	Disclose to all
芦田能基　他	芦田能基　他	芦田能基　他	スピロ環をもたないアプリシアトキシン単純化アナログの合成、配座、および活性	スピロ環をもたないアプリシアトキシン単純化アナログの合成、配座、および活性	スピロ環をもたないアプリシアトキシン単純化アナログの合成、配座、および活性	2018年度日本農芸化学会大会（名城大学、名古屋市）	2018年度日本農芸化学会大会（名城大学、名古屋市）	2018年度日本農芸化学会大会（名城大学、名古屋市）	2018/03		Japanese	Summary of the papers read (national conference and other science council)	Disclose to all
IRIE Kazuhiro	入江一浩	IRIE Kazuhiro	アミロイドβの毒性オリゴマーの構造解析に基づくアルツハイマー病の早期診断法の開発	アミロイドβの毒性オリゴマーの構造解析に基づくアルツハイマー病の早期診断法の開発	アミロイドβの毒性オリゴマーの構造解析に基づくアルツハイマー病の早期診断法の開発	2018年度日本農芸化学会大会（名城大学、名古屋市）	2018年度日本農芸化学会大会（名城大学、名古屋市）	2018年度日本農芸化学会大会（名城大学、名古屋市）	2018/03		Japanese	Summary of the papers read (national conference and other science council)	Disclose to all
Kazuhiro Irie	入江一浩	Kazuhiro Irie	アプリシアトキシン単純化アナログのがん細胞増殖抑制活性	アプリシアトキシン単純化アナログのがん細胞増殖抑制活性	アプリシアトキシン単純化アナログのがん細胞増殖抑制活性	先端モデル動物支援プラットフォーム　成果発表会2017（琵琶湖ホテル、大津市）	先端モデル動物支援プラットフォーム　成果発表会2017（琵琶湖ホテル、大津市）	先端モデル動物支援プラットフォーム　成果発表会2017（琵琶湖ホテル、大津市）	2018/01		Japanese	Summary of the papers read (national conference and other science council)	Disclose to all
鷲崎彩夏　他	鷲崎彩夏　他	鷲崎彩夏　他	新規PKC activator、10-Methyl-Aplog-1はHIV-1を再活性化する有用なLatency Reversing Agentである	新規PKC activator、10-Methyl-Aplog-1はHIV-1を再活性化する有用なLatency Reversing Agentである	新規PKC activator、10-Methyl-Aplog-1はHIV-1を再活性化する有用なLatency Reversing Agentである	第31回日本エイズ学会学術集会・総会（中野サンプラザ、東京都中野区）	第31回日本エイズ学会学術集会・総会（中野サンプラザ、東京都中野区）	第31回日本エイズ学会学術集会・総会（中野サンプラザ、東京都中野区）	2017/11		Japanese	Summary of the papers read (national conference and other science council)	Disclose to all
冨所康志　他	冨所康志　他	冨所康志　他	脳脊髄液中の毒性Aβコンホマーの測定	脳脊髄液中の毒性Aβコンホマーの測定	脳脊髄液中の毒性Aβコンホマーの測定	日本認知症学会学術集会（石川県立音楽堂、金沢市）	第36回日本認知症学会学術集会（石川県立音楽堂、金沢市）	日本認知症学会学術集会（石川県立音楽堂、金沢市）	2017/11		Japanese	Summary of the papers read (national conference and other science council)	Disclose to all
鷲崎彩夏　他	鷲崎彩夏　他	鷲崎彩夏　他	新規PKC activatorである10-methyl-aplog-1はHIV-1再活性化薬として有用である	新規PKC activatorである10-methyl-aplog-1はHIV-1再活性化薬として有用である	新規PKC activatorである10-methyl-aplog-1はHIV-1再活性化薬として有用である	第65回日本ウイルス学会学術集会（大阪国際会議場、大阪市）	第65回日本ウイルス学会学術集会（大阪国際会議場、大阪市）	第65回日本ウイルス学会学術集会（大阪国際会議場、大阪市）	2017/10		Japanese	Summary of the papers read (national conference and other science council)	Disclose to all
Kazuhiro Irie et al.	入江一浩　他	Kazuhiro Irie et al.	神経細胞毒性を有する準安定なアミロイドβの２量体モデルの合成とイオンモビリティー質量分析法による構造解析	神経細胞毒性を有する準安定なアミロイドβの２量体モデルの合成とイオンモビリティー質量分析法による構造解析	神経細胞毒性を有する準安定なアミロイドβの２量体モデルの合成とイオンモビリティー質量分析法による構造解析	第35回メディシナルケミストリーシンポジウム（名古屋大学、名古屋市）	第35回メディシナルケミストリーシンポジウム（名古屋大学、名古屋市）	第35回メディシナルケミストリーシンポジウム（名古屋大学、名古屋市）	2017/10		Japanese	Summary of the papers read (national conference and other science council)	Disclose to all
村上一馬　他	村上一馬　他	村上一馬　他	生薬チョウトウコウに含まれるアミロイドβオリゴマー形成阻害物質の同定と作用機構	生薬チョウトウコウに含まれるアミロイドβオリゴマー形成阻害物質の同定と作用機構	生薬チョウトウコウに含まれるアミロイドβオリゴマー形成阻害物質の同定と作用機構	第59回天然有機化合物討論会（わくわくホリデーホール、札幌市）	第59回天然有機化合物討論会（わくわくホリデーホール、札幌市）	第59回天然有機化合物討論会（わくわくホリデーホール、札幌市）	2017/09	Refereed	Japanese	Summary of the papers read (national conference and other science council)	Disclose to all
Y. Tomidokoro et al.	Y. Tomidokoro et al.	Y. Tomidokoro et al.	Measurement of toxic Aβ conformer in cerebrospinal fluid obtained from the cases of AD dementia	Measurement of toxic Aβ conformer in cerebrospinal fluid obtained from the cases of AD dementia	Measurement of toxic Aβ conformer in cerebrospinal fluid obtained from the cases of AD dementia	XXIII World Congress of Neurology (International Conference Center Kyoto) (Kyoto, Japan)	XXIII World Congress of Neurology (International Conference Center Kyoto) (Kyoto, Japan)	XXIII World Congress of Neurology (International Conference Center Kyoto) (Kyoto, Japan)	2017/09		English	Summary of the papers read (international conference)	Disclose to all
A. Washizaki et al.	A. Washizaki et al.	A. Washizaki et al.	A Novel PKC activator, 10-methyl-aplog-1, induces HIV-1 efficiently in combination with BET inhibitor JQ1	A Novel PKC activator, 10-methyl-aplog-1, induces HIV-1 efficiently in combination with BET inhibitor JQ1	A Novel PKC activator, 10-methyl-aplog-1, induces HIV-1 efficiently in combination with BET inhibitor JQ1	35th Annual Symposium on Nonhuman Primate Models for AIDS (Overture Center for the Arts) (Madison, USA)	35th Annual Symposium on Nonhuman Primate Models for AIDS (Overture Center for the Arts) (Madison, USA)	35th Annual Symposium on Nonhuman Primate Models for AIDS (Overture Center for the Arts) (Madison, USA)	2017/08		English	Summary of the papers read (international conference)	Disclose to all
村上一馬，入江一浩	村上一馬，入江一浩	村上一馬，入江一浩	アミロイドβの毒性配座理論と抗体創製	アミロイドβの毒性配座理論と抗体創製	アミロイドβの毒性配座理論と抗体創製	認知症研究を知る若手研究者の集まり2017（湯の宿木もれび、大津市）	認知症研究を知る若手研究者の集まり2017（湯の宿木もれび、大津市）	認知症研究を知る若手研究者の集まり2017（湯の宿木もれび、大津市）	2017/07		Japanese	Summary of the papers read (national conference and other science council)	Disclose to all
泉尾直孝　他	泉尾直孝　他	泉尾直孝　他	アミロイドβ「毒性コンホマー」を標的にしたアルツハイマー病の治療・診断法の開発	アミロイドβ「毒性コンホマー」を標的にしたアルツハイマー病の治療・診断法の開発	アミロイドβ「毒性コンホマー」を標的にしたアルツハイマー病の治療・診断法の開発	日本薬学会第137年会（仙台国際センター、仙台市）	日本薬学会第137年会（仙台国際センター、仙台市）	日本薬学会第137年会（仙台国際センター、仙台市）	2017/03		Japanese	Summary of the papers read (national conference and other science council)	Disclose to all
花木祐輔　他	花木祐輔　他	花木祐輔　他	Aplysiatoxin単純化アナログ・10-Me-aplog-1のフェノール性側鎖が各種生物活性に与える影響	Aplysiatoxin単純化アナログ・10-Me-aplog-1のフェノール性側鎖が各種生物活性に与える影響	Aplysiatoxin単純化アナログ・10-Me-aplog-1のフェノール性側鎖が各種生物活性に与える影響	2017年度日本農芸化学会大会（京都女子大学、京都市）	2017年度日本農芸化学会大会（京都女子大学、京都市）	2017年度日本農芸化学会大会（京都女子大学、京都市）	2017/03		Japanese	Summary of the papers read (national conference and other science council)	Disclose to all
吉岡卓也　他	吉岡卓也　他	吉岡卓也　他	漢方由来ウンカリン酸 C によるアミロイド β42 核形成阻害メカニズム	漢方由来ウンカリン酸 C によるアミロイド β42 核形成阻害メカニズム	漢方由来ウンカリン酸 C によるアミロイド β42 核形成阻害メカニズム	2017年度日本農芸化学会大会（京都女子大学、京都市）	2017年度日本農芸化学会大会（京都女子大学、京都市）	2017年度日本農芸化学会大会（京都女子大学、京都市）	2017/03		Japanese	Summary of the papers read (national conference and other science council)	Disclose to all
入江由美　他	入江由美　他	入江由美　他	アミロイドβ40の毒性オリゴマーモデル	アミロイドβ40の毒性オリゴマーモデル	アミロイドβ40の毒性オリゴマーモデル	2017年度日本農芸化学会大会（京都女子大学、京都市）	2017年度日本農芸化学会大会（京都女子大学、京都市）	2017年度日本農芸化学会大会（京都女子大学、京都市）	2017/03		Japanese	Summary of the papers read (national conference and other science council)	Disclose to all
村上一馬　他	村上一馬　他	村上一馬　他	アミロイドβ42の35番目でジスルフィド架橋したダイマーの合成と活性評価	アミロイドβ42の35番目でジスルフィド架橋したダイマーの合成と活性評価	アミロイドβ42の35番目でジスルフィド架橋したダイマーの合成と活性評価	2017年度日本農芸化学会大会（京都女子大学、京都市）	2017年度日本農芸化学会大会（京都女子大学、京都市）	2017年度日本農芸化学会大会（京都女子大学、京都市）	2017/03		Japanese	Summary of the papers read (national conference and other science council)	Disclose to all
入江由美　他	入江由美　他	入江由美　他	アミロイドβ40の2量体モデルの合成と神経細胞毒性	アミロイドβ40の2量体モデルの合成と神経細胞毒性	アミロイドβ40の2量体モデルの合成と神経細胞毒性	第35回日本認知症学会学術集会（東京国際フォーラム、東京都千代田区）	第35回日本認知症学会学術集会（東京国際フォーラム、東京都千代田区）	第35回日本認知症学会学術集会（東京国際フォーラム、東京都千代田区）	2016/12		Japanese	Summary of the papers read (national conference and other science council)	Disclose to all
吉岡卓也　他	吉岡卓也　他	吉岡卓也　他	ウンカリン酸によるアミロイドβ凝集核形成の選択的阻害	ウンカリン酸によるアミロイドβ凝集核形成の選択的阻害	ウンカリン酸によるアミロイドβ凝集核形成の選択的阻害	第35回日本認知症学会学術集会（東京国際フォーラム、東京都千代田区）	第35回日本認知症学会学術集会（東京国際フォーラム、東京都千代田区）	第35回日本認知症学会学術集会（東京国際フォーラム、東京都千代田区）	2016/12		Japanese	Summary of the papers read (national conference and other science council)	Disclose to all
村上一馬，入江一浩	村上一馬，入江一浩	村上一馬，入江一浩	天然ポリフェノールによるAβ42凝集阻害機構の解明とアルツハイマー病予防の可能性	天然ポリフェノールによるAβ42凝集阻害機構の解明とアルツハイマー病予防の可能性	天然ポリフェノールによるAβ42凝集阻害機構の解明とアルツハイマー病予防の可能性	第35回日本認知症学会学術集会（東京国際フォーラム、東京都千代田区）	第35回日本認知症学会学術集会（東京国際フォーラム、東京都千代田区）	第35回日本認知症学会学術集会（東京国際フォーラム、東京都千代田区）	2016/12		Japanese	Summary of the papers read (national conference and other science council)	Disclose to all
芦田能基　他	芦田能基　他	芦田能基　他	アプリシアトキシンおよびジアシルグリセロールの受容体認識部位の構造活性相関研究	アプリシアトキシンおよびジアシルグリセロールの受容体認識部位の構造活性相関研究	アプリシアトキシンおよびジアシルグリセロールの受容体認識部位の構造活性相関研究	2016年日本化学会中国四国支部大会　香川大会（香川大学幸町北キャンパス、高松市）	2016年日本化学会中国四国支部大会　香川大会（香川大学幸町北キャンパス、高松市）	2016年日本化学会中国四国支部大会　香川大会（香川大学幸町北キャンパス、高松市）	2016/11		Japanese	Summary of the papers read (national conference and other science council)	Disclose to all
Yusuke Hanaki et al.	花木祐輔　他	Yusuke Hanaki et al.	Structural optimization and mechanistic analysis of the anto-proliferative activity of aplog-1, a simplified analog of debromoaplysiatoxin	デブロモアプリシアトキシン単純化アナログ・aplog-1の構造最適化ならびにがん細胞増殖抑制機構の解析	Structural optimization and mechanistic analysis of the anto-proliferative activity of aplog-1, a simplified analog of debromoaplysiatoxin	58th Symposium on the chemistry of natural products	第58回天然有機化合物討論会（東北大学百周年記念会館川内萩ホール）	58th Symposium on the chemistry of natural products	2016/09	Refereed	Japanese	Summary of the papers read (national conference and other science council)	Disclose to all
N. Izuo et al.	N. Izuo et al.	N. Izuo et al.	Identification of the “toxic conformer” of amyloid β and its pathogenic contribution of Alzheimer’s disease	Identification of the “toxic conformer” of amyloid β and its pathogenic contribution of Alzheimer’s disease	Identification of the “toxic conformer” of amyloid β and its pathogenic contribution of Alzheimer’s disease	2016 Spring International Conference of the Korean Society for Gerontology (Hotel Laonzena, Convention Hall) (Daegu, Korea)	2016 Spring International Conference of the Korean Society for Gerontology (Hotel Laonzena, Convention Hall) (Daegu, Korea)	2016 Spring International Conference of the Korean Society for Gerontology (Hotel Laonzena, Convention Hall) (Daegu, Korea)	2016/06		English	Summary of the papers read (international conference)	Disclose to all
泉尾直孝　他	泉尾直孝　他	泉尾直孝　他	Aβ42の22-23位におけるターン構造はAβ42誘発神経毒性を調節する	Aβ42の22-23位におけるターン構造はAβ42誘発神経毒性を調節する	Aβ42の22-23位におけるターン構造はAβ42誘発神経毒性を調節する	日本基礎老化学会大会（伊勢原市民文化会館、伊勢原市）	日本基礎老化学会大会（伊勢原市民文化会館、伊勢原市）	日本基礎老化学会大会（伊勢原市民文化会館、伊勢原市）	2016/05		Japanese	Summary of the papers read (national conference and other science council)	Disclose to all
村上一馬　他	村上一馬　他	村上一馬　他	アミロイドβの毒性コンホマーにきわめて特異的な抗体の開発とアルツハイマー病診断への応用	アミロイドβの毒性コンホマーにきわめて特異的な抗体の開発とアルツハイマー病診断への応用	アミロイドβの毒性コンホマーにきわめて特異的な抗体の開発とアルツハイマー病診断への応用	2016年度日本農芸化学会大会（札幌コンベンションセンター、札幌市）	2016年度日本農芸化学会大会（札幌コンベンションセンター、札幌市）	2016年度日本農芸化学会大会（札幌コンベンションセンター、札幌市）	2016/03		Japanese	Summary of the papers read (national conference and other science council)	Disclose to all
花木祐輔　他	花木祐輔　他	花木祐輔　他	新規抗がん剤シード・10-Me-aplog-1のがん細胞増殖抑制機構	新規抗がん剤シード・10-Me-aplog-1のがん細胞増殖抑制機構	新規抗がん剤シード・10-Me-aplog-1のがん細胞増殖抑制機構	2016年度日本農芸化学会大会（札幌コンベンションセンター、札幌市）	2016年度日本農芸化学会大会（札幌コンベンションセンター、札幌市）	2016年度日本農芸化学会大会（札幌コンベンションセンター、札幌市）	2016/03		Japanese	Summary of the papers read (national conference and other science council)	Disclose to all
吉岡卓也　他	吉岡卓也　他	吉岡卓也　他	チョウトウコウに含まれるウンカリン酸Ｃおよびその誘導体のアミロイドβ凝集阻害活性	チョウトウコウに含まれるウンカリン酸Ｃおよびその誘導体のアミロイドβ凝集阻害活性	チョウトウコウに含まれるウンカリン酸Ｃおよびその誘導体のアミロイドβ凝集阻害活性	2016年度日本農芸化学会大会（札幌コンベンションセンター、札幌市）	2016年度日本農芸化学会大会（札幌コンベンションセンター、札幌市）	2016年度日本農芸化学会大会（札幌コンベンションセンター、札幌市）	2016/03		Japanese	Summary of the papers read (national conference and other science council)	Disclose to all
芦田能基　他	芦田能基　他	芦田能基　他	分子モデリングによるAplysiatoxinとプロテインキナーゼC C1ドメインとの結合様式の予測	分子モデリングによるAplysiatoxinとプロテインキナーゼC C1ドメインとの結合様式の予測	分子モデリングによるAplysiatoxinとプロテインキナーゼC C1ドメインとの結合様式の予測	2016年度日本農芸化学会大会（札幌コンベンションセンター、札幌市）	2016年度日本農芸化学会大会（札幌コンベンションセンター、札幌市）	2016年度日本農芸化学会大会（札幌コンベンションセンター、札幌市）	2016/03		Japanese	Summary of the papers read (national conference and other science council)	Disclose to all
高橋知世　他	高橋知世　他	高橋知世　他	Thapsigargin のC1ドメインに対する結合能と結合選択性の評価	Thapsigargin のC1ドメインに対する結合能と結合選択性の評価	Thapsigargin のC1ドメインに対する結合能と結合選択性の評価	2016年度日本農芸化学会大会（札幌コンベンションセンター、札幌市）	2016年度日本農芸化学会大会（札幌コンベンションセンター、札幌市）	2016年度日本農芸化学会大会（札幌コンベンションセンター、札幌市）	2016/03		Japanese	Summary of the papers read (national conference and other science council)	Disclose to all
泉尾直孝　他	泉尾直孝　他	泉尾直孝　他	Passive immunization with the toxic conformer of Aβ ameliorated behavioral abnormalities in Alzheimer’s-like model without affecting senile plaque deposition	Passive immunization with the toxic conformer of Aβ ameliorated behavioral abnormalities in Alzheimer’s-like model without affecting senile plaque deposition	Passive immunization with the toxic conformer of Aβ ameliorated behavioral abnormalities in Alzheimer’s-like model without affecting senile plaque deposition	第89回日本薬理学会年会（パシフィコ横浜、横浜市）	第89回日本薬理学会年会（パシフィコ横浜、横浜市）	第89回日本薬理学会年会（パシフィコ横浜、横浜市）	2016/03		Japanese	Summary of the papers read (national conference and other science council)	Disclose to all
花木祐輔　他	花木祐輔　他	花木祐輔　他	新規抗がん剤シード・aplog類のがん細胞増殖抑制機構の解析	新規抗がん剤シード・aplog類のがん細胞増殖抑制機構の解析	新規抗がん剤シード・aplog類のがん細胞増殖抑制機構の解析	新学術領域研究「天然物ケミカルバイオロジー〜分子標的と活性制御〜」地区ミニシンポジウム（京都大学、京都市）	新学術領域研究「天然物ケミカルバイオロジー〜分子標的と活性制御〜」地区ミニシンポジウム（京都大学、京都市）	新学術領域研究「天然物ケミカルバイオロジー〜分子標的と活性制御〜」地区ミニシンポジウム（京都大学、京都市）	2016/02		Japanese	Summary of the papers read (national conference and other science council)	Disclose to all
K. Murakami et al.	K. Murakami et al.	K. Murakami et al.	Characterization of the monoclonal antibody (24B3) highly recognizing the toxic turn of amyloid β42 and its application to diagnosis for Alzheimer’s disease	Characterization of the monoclonal antibody (24B3) highly recognizing the toxic turn of amyloid β42 and its application to diagnosis for Alzheimer’s disease	Characterization of the monoclonal antibody (24B3) highly recognizing the toxic turn of amyloid β42 and its application to diagnosis for Alzheimer’s disease	The 8th Takeda Science Foundation Symposium on PharmaSciences “Biomolecule-based Medicinal Science: Featuring Mid-Size Drugs” (Takeda Pharmaceutical Company, Ltd.) (Suita, Japan)	The 8th Takeda Science Foundation Symposium on PharmaSciences “Biomolecule-based Medicinal Science: Featuring Mid-Size Drugs” (Takeda Pharmaceutical Company, Ltd.) (Suita, Japan)	The 8th Takeda Science Foundation Symposium on PharmaSciences “Biomolecule-based Medicinal Science: Featuring Mid-Size Drugs” (Takeda Pharmaceutical Company, Ltd.) (Suita, Japan)	2016/01		English	Summary of the papers read (international conference)	Disclose to all
Y. Hanaki et al.	Y. Hanaki et al.	Y. Hanaki et al.	Large-scale synthesis, anti-cancer activity in vivo, and mechanism of anti-proliferative activity of 10-methyl-aplog-1, a simplified analog of aplysiatoxin, as an anti-cancer lead	Large-scale synthesis, anti-cancer activity in vivo, and mechanism of anti-proliferative activity of 10-methyl-aplog-1, a simplified analog of aplysiatoxin, as an anti-cancer lead	Large-scale synthesis, anti-cancer activity in vivo, and mechanism of anti-proliferative activity of 10-methyl-aplog-1, a simplified analog of aplysiatoxin, as an anti-cancer lead	The 8th Takeda Science Foundation Symposium on PharmaSciences “Biomolecule-based Medicinal Science: Featuring Mid-Size Drugs” (Takea Pharmaceutical Company, Ltd.) (Suita, Japan)	The 8th Takeda Science Foundation Symposium on PharmaSciences “Biomolecule-based Medicinal Science: Featuring Mid-Size Drugs” (Takeda Pharmaceutical Company, Ltd.) (Suita, Japan)	The 8th Takeda Science Foundation Symposium on PharmaSciences “Biomolecule-based Medicinal Science: Featuring Mid-Size Drugs” (Takea Pharmaceutical Company, Ltd.) (Suita, Japan)	2016/01		English	Summary of the papers read (international conference)	Disclose to all
M. Hanaki et al.	M. Hanaki et al.	M. Hanaki et al.	Structural insight into the inhibitory mechanism of amyloid β42 aggregation by non-catechol-type flavonoids	Structural insight into the inhibitory mechanism of amyloid β42 aggregation by non-catechol-type flavonoids	Structural insight into the inhibitory mechanism of amyloid β42 aggregation by non-catechol-type flavonoids	2015 International Chemical Congress of Pacific Basin Societies (PACIFICHEM 2015) (Hawaii, USA)	2015 International Chemical Congress of Pacific Basin Societies (PACIFICHEM 2015) (Hawaii, USA)	2015 International Chemical Congress of Pacific Basin Societies (PACIFICHEM 2015) (Hawaii, USA)	2015/12		English	Summary of the papers read (international conference)	Disclose to all
K. Murakami et al.	K. Murakami et al.	K. Murakami et al.	Characterization of monoclonal antibodies against the toxic turn of amyloid β42 and their application to diagnosis for Alzheimer’s disease.	Characterization of monoclonal antibodies against the toxic turn of amyloid β42 and their application to diagnosis for Alzheimer’s disease.	Characterization of monoclonal antibodies against the toxic turn of amyloid β42 and their application to diagnosis for Alzheimer’s disease.	2015 International Chemical Congress of Pacific Basin Societies (PACIFICHEM 2015) (Hawaii, USA)	2015 International Chemical Congress of Pacific Basin Societies (PACIFICHEM 2015) (Hawaii, USA)	2015 International Chemical Congress of Pacific Basin Societies (PACIFICHEM 2015) (Hawaii, USA)	2015/12		English	Summary of the papers read (international conference)	Disclose to all
Y. Hanaki et al.	Y. Hanaki et al.	Y. Hanaki et al.	Synthesis and biological activities of the amide derivative of aplog-1	Synthesis and biological activities of the amide derivative of aplog-1	Synthesis and biological activities of the amide derivative of aplog-1	2015 International Chemical Congress of Pacific Basin Societies (PACIFICHEM 2015) (Hawaii, USA)	2015 International Chemical Congress of Pacific Basin Societies (PACIFICHEM 2015) (Hawaii, USA)	2015 International Chemical Congress of Pacific Basin Societies (PACIFICHEM 2015) (Hawaii, USA)	2015/12		English	Summary of the papers read (international conference)	Disclose to all
R. C. Yanagita et al.	R. C. Yanagita et al.	R. C. Yanagita et al.	Isolation and ability to bind to protein kinase C of (20S)-bryostatin 19 from Japanese bryozoan: elucidation of the role of the side-chain at position 20	Isolation and ability to bind to protein kinase C of (20S)-bryostatin 19 from Japanese bryozoan: elucidation of the role of the side-chain at position 20	Isolation and ability to bind to protein kinase C of (20S)-bryostatin 19 from Japanese bryozoan: elucidation of the role of the side-chain at position 20	2015 International Chemical Congress of Pacific Basin Societies (PACIFICHEM 2015) (Hawaii, USA)	2015 International Chemical Congress of Pacific Basin Societies (PACIFICHEM 2015) (Hawaii, USA)	2015 International Chemical Congress of Pacific Basin Societies (PACIFICHEM 2015) (Hawaii, USA)	2015/12		English	Summary of the papers read (international conference)	Disclose to all
Y. Ashida et al.	Y. Ashida et al.	Y. Ashida et al.	Structure–activity studies on the PKC-recognition domain of aplysiatoxin, a potent tumor-promoter isolated from a sea hare	Structure–activity studies on the PKC-recognition domain of aplysiatoxin, a potent tumor-promoter isolated from a sea hare	Structure–activity studies on the PKC-recognition domain of aplysiatoxin, a potent tumor-promoter isolated from a sea hare	2015 International Chemical Congress of Pacific Basin Societies (PACIFICHEM 2015) (Hawaii, USA)	2015 International Chemical Congress of Pacific Basin Societies (PACIFICHEM 2015) (Hawaii, USA)	2015 International Chemical Congress of Pacific Basin Societies (PACIFICHEM 2015) (Hawaii, USA)	2015/12		English	Summary of the papers read (international conference)	Disclose to all
W. Jiang et al.	W. Jiang et al.	W. Jiang et al.	New lyngbyatoxin derivatives from the Hawaiian cyanobacterium Moorea producens	New lyngbyatoxin derivatives from the Hawaiian cyanobacterium Moorea producens	New lyngbyatoxin derivatives from the Hawaiian cyanobacterium Moorea producens	2015 International Chemical Congress of Pacific Basin Societies (PACIFICHEM 2015) (Hawaii, USA)	2015 International Chemical Congress of Pacific Basin Societies (PACIFICHEM 2015) (Hawaii, USA)	2015 International Chemical Congress of Pacific Basin Societies (PACIFICHEM 2015) (Hawaii, USA)	2015/12		English	Summary of the papers read (international conference)	Disclose to all
K. Irie et al.	K. Irie et al.	K. Irie et al.	Extraction of anti-proliferative activity from pleiotropic debromoaplysiatoxin, a potent tumor promoter and a highly inflammatory principle isolated from sea hare	Extraction of anti-proliferative activity from pleiotropic debromoaplysiatoxin, a potent tumor promoter and a highly inflammatory principle isolated from sea hare	Extraction of anti-proliferative activity from pleiotropic debromoaplysiatoxin, a potent tumor promoter and a highly inflammatory principle isolated from sea hare	2015 International Chemical Congress of Pacific Basin Societies (PACIFICHEM 2015) (Hawaii, USA)	2015 International Chemical Congress of Pacific Basin Societies (PACIFICHEM 2015) (Hawaii, USA)	2015 International Chemical Congress of Pacific Basin Societies (PACIFICHEM 2015) (Hawaii, USA)	2015/12		English	Summary of the papers read (international conference)	Disclose to all
泉尾直孝　他	泉尾直孝　他	泉尾直孝　他	Aβ毒性コンホマーの選択的除去は老人班蓄積を阻害せずにアルツハイマー病モデルマウスの行動異常を改善する	Aβ毒性コンホマーの選択的除去は老人班蓄積を阻害せずにアルツハイマー病モデルマウスの行動異常を改善する	Aβ毒性コンホマーの選択的除去は老人班蓄積を阻害せずにアルツハイマー病モデルマウスの行動異常を改善する	第38回日本分子生物学会年会（神戸ポートアイランド、神戸市）	第38回日本分子生物学会年会（神戸ポートアイランド、神戸市）	第38回日本分子生物学会年会（神戸ポートアイランド、神戸市）	2015/12		Japanese	Summary of the papers read (national conference and other science council)	Disclose to all
川上隆史　他	川上隆史　他	川上隆史　他	In vitro display evolution of cyclized peptidomimetics to a chemically synthesized amyloid beta protein dimer	In vitro display evolution of cyclized peptidomimetics to a chemically synthesized amyloid beta protein dimer	In vitro display evolution of cyclized peptidomimetics to a chemically synthesized amyloid beta protein dimer	第52回ペプチド討論会(平塚中央公民館、平塚市）	第52回ペプチド討論会(平塚中央公民館、平塚市）	第52回ペプチド討論会(平塚中央公民館、平塚市）	2015/11		Japanese	Summary of the papers read (national conference and other science council)	Disclose to all
村上一馬，入江一浩	村上一馬，入江一浩*	村上一馬，入江一浩	アミロイドβの毒性配座理論に基づいた構造特異抗体の開発と診断薬への応用	アミロイドβの毒性配座理論に基づいた構造特異抗体の開発と診断薬への応用	アミロイドβの毒性配座理論に基づいた構造特異抗体の開発と診断薬への応用	第8回たんぱく質の異常凝集とその防御・修復機構に関する研究会（京都大学原子炉実験所、熊取町）	第8回たんぱく質の異常凝集とその防御・修復機構に関する研究会（京都大学原子炉実験所、熊取町）	第8回たんぱく質の異常凝集とその防御・修復機構に関する研究会（京都大学原子炉実験所、熊取町）	2015/11		Japanese	Summary of the papers read (national conference and other science council)	Disclose to all
泉尾直孝　他	泉尾直孝　他	泉尾直孝　他	Aβ 毒性コンホマーの選択的除去は老人斑に影響せずアルツハイマー病症状を改善する	Aβ 毒性コンホマーの選択的除去は老人斑に影響せずアルツハイマー病症状を改善する	Aβ 毒性コンホマーの選択的除去は老人斑に影響せずアルツハイマー病症状を改善する	第34回日本認知症学会学術集会（リンクステーションホール青森）	第34回日本認知症学会学術集会（リンクステーションホール青森）		2015/10		Japanese	Summary of the papers read (national conference and other science council)	Disclose to all
村上一馬　他	村上一馬　他	村上一馬　他	アミロイドβの毒性コンホマーを極めて特異的に認識する抗体の開発とAD診断への応用	アミロイドβの毒性コンホマーを極めて特異的に認識する抗体の開発とAD診断への応用	アミロイドβの毒性コンホマーを極めて特異的に認識する抗体の開発とAD診断への応用	第34回日本認知症学会学術集会（リンクステーションホール青森）	第34回日本認知症学会学術集会（リンクステーションホール青森）	第34回日本認知症学会学術集会（リンクステーションホール青森）	2015/10		Japanese	Summary of the papers read (national conference and other science council)	Disclose to all
花木瑞穂　他	花木瑞穂　他	花木瑞穂　他	SOFAST-HMQC NMR を用いた非カテコール型フラボノイドによるアミロイドβの凝集抑制機構の解析	SOFAST-HMQC NMR を用いた非カテコール型フラボノイドによるアミロイドβの凝集抑制機構の解析	SOFAST-HMQC NMR を用いた非カテコール型フラボノイドによるアミロイドβの凝集抑制機構の解析	2015年度日本農芸化学会中部・関西支部合同大会（富山県立大学）	2015年度日本農芸化学会中部・関西支部合同大会（富山県立大学）	2015年度日本農芸化学会中部・関西支部合同大会（富山県立大学）	2015/09		Japanese	Summary of the papers read (national conference and other science council)	Disclose to all
花木瑞穂　他	花木瑞穂　他	花木瑞穂　他	非カテコール型フラボノイドによるアミロイドβの凝集抑制機構	非カテコール型フラボノイドによるアミロイドβの凝集抑制機構	非カテコール型フラボノイドによるアミロイドβの凝集抑制機構	第57回天然有機化合物討論会（神奈川県民ホール）	第57回天然有機化合物討論会（神奈川県民ホール）	第57回天然有機化合物討論会（神奈川県民ホール）	2015/09	Refereed	Japanese	Summary of the papers read (national conference and other science council)	Disclose to all
K. Murakami and K. Irie	村上一馬，入江一浩*	K. Murakami and K. Irie	アミロイドβペプチドの毒性配座理論に基づいた構造特異抗体の開発と診断薬への応用	アミロイドβペプチドの毒性配座理論に基づいた構造特異抗体の開発と診断薬への応用	アミロイドβペプチドの毒性配座理論に基づいた構造特異抗体の開発と診断薬への応用	第47回若手ペプチド夏の勉強会、信州塩尻・天然温泉アスティかたおか（塩尻市）	第47回若手ペプチド夏の勉強会、信州塩尻・天然温泉アスティかたおか（塩尻市）	第47回若手ペプチド夏の勉強会、信州塩尻・天然温泉アスティかたおか（塩尻市）	2015/08		Japanese	Summary of the papers read (national conference and other science council)	Disclose to all
N. Izuo et al.	泉尾直孝　他	N. Izuo et al.	Aβ毒性コンホマーの選択的除去は老人班形成を阻害せずにアルツハイマー病モデルマウスの行動異常を改善する	Aβ毒性コンホマーの選択的除去は老人班形成を阻害せずにアルツハイマー病モデルマウスの行動異常を改善する	Aβ毒性コンホマーの選択的除去は老人班形成を阻害せずにアルツハイマー病モデルマウスの行動異常を改善する	第5回認知症研究を知る若手研究者の集まり2015（高崎市）	第5回認知症研究を知る若手研究者の集まり2015（高崎市）	第5回認知症研究を知る若手研究者の集まり2015（高崎市）	2015/08		Japanese	Summary of the papers read (national conference and other science council)	Disclose to all
江偉娜　他	江偉娜　他		ハワイ産ラン藻Moorea producens由来の新規lyngbyatoxin A誘導体類の構造ならびに活性	ハワイ産ラン藻Moorea producens由来の新規lyngbyatoxin A誘導体類の構造ならびに活性		第62回トキシンシンポジウム（志摩市）	第62回トキシンシンポジウム（志摩市）		2015/07		Japanese	Summary of the papers read (national conference and other science council)	Disclose to all
Naotaka Izuo	泉尾直孝　他	Naotaka Izuo	Passive immunotherapy targeting to the “toxic conformer” of amyloid β ameliorates neurological symptom in Alzheimer’s disease model	アミロイドβの「毒性コンホマー」を標的とした受動免疫療法はアルツハイマー病モデルの神経症状を改善する	Passive immunotherapy targeting to the “toxic conformer” of amyloid β ameliorates neurological symptom in Alzheimer’s disease model	第38回　日本基礎老化学会大会（パシフィコ横浜）	第38回　日本基礎老化学会大会（パシフィコ横浜）		2015/06		Japanese	Summary of the papers read (national conference and other science council)	Disclose to all
宮前友策　他	宮前友策　他		リガンド結合ポケットの特性を利用した新規共有結合性PPARγアゴニストの創製	リガンド結合ポケットの特性を利用した新規共有結合性PPARγアゴニストの創製		日本ケミカルバイオロジー学会第10回年会（仙台）	日本ケミカルバイオロジー学会第10回年会（仙台）		2015/06		Japanese	Summary of the papers read (national conference and other science council)	Disclose to all
芦田能基　他	芦田能基　他		AplysiatoxinのPKC C1ドメイン認識部位の構造活性相関研究	AplysiatoxinのPKC C1ドメイン認識部位の構造活性相関研究		2015年度日本農芸化学会大会（岡山）	2015年度日本農芸化学会大会（岡山）		2015/03		Japanese	Summary of the papers read (national conference and other science council)	Disclose to all
泉尾直孝　他	泉尾直孝　他		Pathophysiological activities of the “toxic conformer” and the “non-toxic conformer” of amyloid β-induced neurotoxicity	Pathophysiological activities of the “toxic conformer” and the “non-toxic conformer” of amyloid β-induced neurotoxicity	Pathophysiological activities of the “toxic conformer” and the “non-toxic conformer” of amyloid β-induced neurotoxicity	第88回日本薬理学会年会（名古屋国際会議場）	第88回日本薬理学会年会（名古屋国際会議場）		2015/03		Japanese	Summary of the papers read (national conference and other science council)	Disclose to all
徳田真樹　他	徳田真樹　他		アミロイドβ42ダイマーの合成と活性評価	アミロイドβ42ダイマーの合成と活性評価		2015年度日本農芸化学会大会（岡山）	2015年度日本農芸化学会大会（岡山）		2015/03		Japanese	Summary of the papers read (national conference and other science council)	Disclose to all
花木祐輔　他	花木祐輔　他		細胞増殖抑制能を有するアプリシアトキシン単純化アナログのアミド誘導体の合成と活性	細胞増殖抑制能を有するアプリシアトキシン単純化アナログのアミド誘導体の合成と活性		2015年度日本農芸化学会大会（岡山）	2015年度日本農芸化学会大会（岡山）		2015/03		Japanese	Summary of the papers read (national conference and other science council)	Disclose to all
村木謙介　他	村木謙介　他		日本産フサコケムシからの新規bryostatin類の単離と活性	日本産フサコケムシからの新規bryostatin類の単離と活性		2015年度日本農芸化学会大会（岡山）	2015年度日本農芸化学会大会（岡山）		2015/03		Japanese	Summary of the papers read (national conference and other science council)	Disclose to all
宮前友策　他	宮前友策　他		リガンド結合ポケットの特性に基づく新規共有結合性PPARγアゴニストの創製	リガンド結合ポケットの特性に基づく新規共有結合性PPARγアゴニストの創製		2015年度日本農芸化学会大会（岡山）	2015年度日本農芸化学会大会（岡山）		2015/03		Japanese	Summary of the papers read (national conference and other science council)	Disclose to all
佐藤瑞穂　他	佐藤瑞穂　他	佐藤瑞穂　他	非カテコール型フラボノイドによるアミロイドβ42の凝集抑制機構	非カテコール型フラボノイドによるアミロイドβ42の凝集抑制機構	非カテコール型フラボノイドによるアミロイドβ42の凝集抑制機構	第33回日本認知症学会学術集会（横浜）	第33回日本認知症学会学術集会（横浜）	第33回日本認知症学会学術集会（横浜）	2014/11	Refereed	Japanese	Summary of the papers read (national conference and other science council)	Disclose to all
江偉娜　他	江偉娜　他	江偉娜　他	ラン藻Moorea producensより単離した新規lyngbyatoxin A誘導体の構造および生物活性	ラン藻Moorea producensより単離した新規lyngbyatoxin A誘導体の構造および生物活性	ラン藻Moorea producensより単離した新規lyngbyatoxin A誘導体の構造および生物活性	第56回天然有機化合物討論会（高知市）	第56回天然有機化合物討論会（高知市）	第56回天然有機化合物討論会（高知市）	2014/10	Refereed	Japanese	Summary of the papers read (national conference and other science council)	Disclose to all
宮前友策　他	宮前友策　他		非共有結合性リガンドの開発を目指した新規PPARγ活性化機構の解明	非共有結合性リガンドの開発を目指した新規PPARγ活性化機構の解明		第56回天然有機化合物討論会（高知市）	第56回天然有機化合物討論会（高知市）		2014/10	Refereed	Japanese	Summary of the papers read (national conference and other science council)	Disclose to all
M. Sato et al.	M. Sato et al.	M. Sato et al.	Structural insights into inhibitory ability of flavonoids for Aβ42 aggregation	Structural insights into inhibitory ability of flavonoids for Aβ42 aggregation	Structural insights into inhibitory ability of flavonoids for Aβ42 aggregation	XXVIIth International Confefence on Polyphenols (Nagoya, Japan)	XXVIIth International Confefence on Polyphenols (Nagoya, Japan)	XXVIIth International Confefence on Polyphenols (Nagoya, Japan)	2014/09	Refereed	English	Summary of the papers read (international conference)	Disclose to all
K. Irie et al.	K. Irie et al.	K. Irie et al.	Synthesis and biological activities of the Aβ40 dimer with toxic conformation	Synthesis and biological activities of the Aβ40 dimer with toxic conformation	Synthesis and biological activities of the Aβ40 dimer with toxic conformation	Alzheimer’s Association International Conference (Bella Center A/S, Copenhagen, Denmark)	Alzheimer’s Association International Conference (Bella Center A/S, Copenhagen, Denmark)	Alzheimer’s Association International Conference (Bella Center A/S, Copenhagen, Denmark)	2014/07	Refereed	English	Summary of the papers read (international conference)	Disclose to all
K. Murakami et al.	K. Murakami et al.	K. Murakami et al.	Inhibitors for Aβ42 aggregation in a traditional herbal medicine Uncaria rhynchophylla	Inhibitors for Aβ42 aggregation in a traditional herbal medicine Uncaria rhynchophylla	Inhibitors for Aβ42 aggregation in a traditional herbal medicine Uncaria rhynchophylla	Alzheimer’s Association International Conference (Bella Center A/S, Copenhagen, Denmark)	Alzheimer’s Association International Conference (Bella Center A/S, Copenhagen, Denmark)	Alzheimer’s Association International Conference (Bella Center A/S, Copenhagen, Denmark)	2014/07	Refereed	English	Summary of the papers read (international conference)	Disclose to all
泉尾直孝　他	泉尾直孝　他	泉尾直孝　他	Identification of the “toxic conformer” of amyloid β in Alzheimer’s disease	Identification of the “toxic conformer” of amyloid β in Alzheimer’s disease	Identification of the “toxic conformer” of amyloid β in Alzheimer’s disease	日本基礎老化学会大会（横浜）	日本基礎老化学会大会（横浜）	日本基礎老化学会大会（横浜）	2014/06		Japanese	Summary of the papers read (national conference and other science council)	Disclose to all
Jiang, W. et al.	Jiang, W. et al.	Jiang, W. et al.	12-Epi-lyngbyatoxin A, a new toxic substance from the cyanobacteria Moorea producens	12-Epi-lyngbyatoxin A, a new toxic substance from the cyanobacteria Moorea producens	12-Epi-lyngbyatoxin A, a new toxic substance from the cyanobacteria Moorea producens	The Asia-Pacific Section Congress of International Society of Toxicology (Changsha, China)	The Asia-Pacific Section Congress of International Society of Toxicology (Changsha, China)	The Asia-Pacific Section Congress of International Society of Toxicology (Changsha, China)	2014/06		English	Summary of the papers read (international conference)	Disclose to all
菊森将之　他	菊森将之　他		アプリシアトキシン単純化アナログ (Aplog-1) の抗がん剤シーズとしての構造最適化	アプリシアトキシン単純化アナログ (Aplog-1) の抗がん剤シーズとしての構造最適化		新学術領域研究・がん支援「化学療法基盤支援活動」第3回シンポジウム（名護市、万国津梁館）	新学術領域研究・がん支援「化学療法基盤支援活動」第3回シンポジウム（名護市、万国津梁館）		2014/05	Refereed	Japanese	Summary of the papers read (national conference and other science council)	Disclose to all
村上一馬　他	村上一馬　他		伝統生薬チョウトウコウに含まれるアミロイドβ凝集抑制物質	伝統生薬チョウトウコウに含まれるアミロイドβ凝集抑制物質		2014年度日本農芸化学会大会（東京）	2014年度日本農芸化学会大会（東京）		2014/03		Japanese	Summary of the papers read (national conference and other science council)	Disclose to all
佐藤瑞穂　他	佐藤瑞穂　他		非カテコール型フラボノイドによるアミロイドβ42凝集抑制機構	非カテコール型フラボノイドによるアミロイドβ42凝集抑制機構		2014年度日本農芸化学会大会（東京）	2014年度日本農芸化学会大会（東京）		2014/03		Japanese	Summary of the papers read (national conference and other science council)	Disclose to all
鈴木天志　他	鈴木天志　他		アミロイドβダイマーの合成と活性評価	アミロイドβダイマーの合成と活性評価		2014年度日本農芸化学会大会（東京）	2014年度日本農芸化学会大会（東京）		2014/03		Japanese	Summary of the papers read (national conference and other science council)	Disclose to all
菊森将之　他	菊森将之　他		Debromoaplysiatoxinの4位不斉メチル基の生物活性おける役割	Debromoaplysiatoxinの4位不斉メチル基の生物活性おける役割		2014年度日本農芸化学会大会（東京）	2014年度日本農芸化学会大会（東京）		2014/03		Japanese	Summary of the papers read (national conference and other science council)	Disclose to all
M. Sato et al.	M. Sato et al.	M. Sato et al.	Site-specific inhibitory mechanisms for amyloid β aggregation by catechol-type flavonoids	Site-specific inhibitory mechanisms for amyloid β aggregation by catechol-type flavonoids	Site-specific inhibitory mechanisms for amyloid β aggregation by catechol-type flavonoids	Institute for Chemical Research International Symposium 2014 (Kyoto, Japan)	Institute for Chemical Research International Symposium 2014 (Kyoto, Japan)	Institute for Chemical Research International Symposium 2014 (Kyoto, Japan)	2014/03		English	Summary of the papers read (international conference)	Disclose to all
泉尾直孝　他	泉尾直孝　他		Induction of oxidative stress by the “toxic conformer” is crucial for Aβ42 neurotoxicity	Induction of oxidative stress by the “toxic conformer” is crucial for Aβ42 neurotoxicity		第87回日本薬理学会年会（仙台）	第87回日本薬理学会年会（仙台）		2014/03		Japanese	Summary of the papers read (national conference and other science council)	Disclose to all
泉尾直孝　他	泉尾直孝　他		Aβ42誘発神経毒性には、「毒性コンホマー」による酸化ストレス誘導が重要である	Aβ42誘発神経毒性には、「毒性コンホマー」による酸化ストレス誘導が重要である		第36回日本分子生物学会年会（神戸）	第36回日本分子生物学会年会（神戸）		2013/12		Japanese	Summary of the papers read (national conference and other science council)	Disclose to all
佐藤瑞穂　他	佐藤瑞穂　他		カテコール型フラボノイド類のアミロイドβ凝集抑制機構	カテコール型フラボノイド類のアミロイドβ凝集抑制機構		第32回日本認知症学会学術集会（松本）	第32回日本認知症学会学術集会（松本）		2013/11	Refereed	Japanese	Summary of the papers read (national conference and other science council)	Disclose to all
村上一馬　他	村上一馬　他		ポリフェノールによるアミロイドβ42の凝集抑制機構	ポリフェノールによるアミロイドβ42の凝集抑制機構		第6回タンパク質の異常凝集とその防御・修復機構に関する研究会（京都大学原子炉実験所）	第6回タンパク質の異常凝集とその防御・修復機構に関する研究会（京都大学原子炉実験所）		2013/11		Japanese	Summary of the papers read (national conference and other science council)	Disclose to all
M. Sato et al.	M. Sato et al.	M. Sato et al.	Specific inhibitory mechanisms for Aβ42 aggregation by flavonoids	Specific inhibitory mechanisms for Aβ42 aggregation by flavonoids	Specific inhibitory mechanisms for Aβ42 aggregation by flavonoids	Alzheimer's Association International Conference (AAIC) 2013 (Boston, USA)	Alzheimer's Association International Conference (AAIC) 2013 (Boston, USA)	Alzheimer's Association International Conference (AAIC) 2013 (Boston, USA)	2013/07		English	Summary of the papers read (international conference)	Disclose to all
K. Murakami et al.	K. Murakami et al.	K. Murakami et al.	Vitamin C and silymarin restores Aβ oligomerization and behavioral abnormality in Alzheimer’s pathology	Vitamin C and silymarin restores Aβ oligomerization and behavioral abnormality in Alzheimer’s pathology	Vitamin C and silymarin restores Aβ oligomerization and behavioral abnormality in Alzheimer’s pathology	Alzheimer's Association International Conference (AAIC) 2013 in Boston, USA	Alzheimer's Association International Conference (AAIC) 2013 in Boston, USA	Alzheimer's Association International Conference (AAIC) 2013 in Boston, USA	2013/07		English	Summary of the papers read (international conference)	Disclose to all
M. Kikumori et al.	M. Kikumori et al.	M. Kikumori et al.	Role of methyl groups on the spiroketal moiety of aplog-1, a simplified analogue of debromoaplysiatoxin with anti-proliferative activity	Role of methyl groups on the spiroketal moiety of aplog-1, a simplified analogue of debromoaplysiatoxin with anti-proliferative activity	Role of methyl groups on the spiroketal moiety of aplog-1, a simplified analogue of debromoaplysiatoxin with anti-proliferative activity	23rd French-Japanese Symposium of Medicinal and Fine Chemistry (Nagasaki, Japan)	23rd French-Japanese Symposium of Medicinal and Fine Chemistry (Nagasaki, Japan)	23rd French-Japanese Symposium of Medicinal and Fine Chemistry (Nagasaki, Japan)	2013/05		English	Summary of the papers read (international conference)	Disclose to all
佐藤瑞穂　他	佐藤瑞穂　他		自動酸化によるアポモルフィンのアミロイドβ凝集阻害機構の解析	自動酸化によるアポモルフィンのアミロイドβ凝集阻害機構の解析		2013年度日本農芸化学会大会（仙台）	2013年度日本農芸化学会大会（仙台）		2013/03		Japanese	Summary of the papers read (national conference and other science council)	Disclose to all
村上一馬　他	村上一馬　他		ビタミンCによるアルツハイマー病態緩和	ビタミンCによるアルツハイマー病態緩和		2013年度日本農芸化学会大会（仙台）	2013年度日本農芸化学会大会（仙台）		2013/03		Japanese	Summary of the papers read (national conference and other science council)	Disclose to all
花木祐輔　他	花木祐輔　他		Debromoaplysiatoxin単純化アナログの27位における構造活性相関	Debromoaplysiatoxin単純化アナログの27位における構造活性相関		2013年度日本農芸化学会大会（仙台）	2013年度日本農芸化学会大会（仙台）		2013/03		Japanese	Summary of the papers read (national conference and other science council)	Disclose to all
菊森将之　他	菊森将之　他		Debromoaplysiatoxin単純化アナログの10位メチル体の発がん促進活性	Debromoaplysiatoxin単純化アナログの10位メチル体の発がん促進活性		2013年度日本農芸化学会大会（仙台）	2013年度日本農芸化学会大会（仙台）		2013/03		Japanese	Summary of the papers read (national conference and other science council)	Disclose to all
泉　安彦　他	泉　安彦　他		青ジソ抽出物からのNrf2-ARE経路活性化成分の単離および同定	青ジソ抽出物からのNrf2-ARE経路活性化成分の単離および同定		第85回日本薬理学会年会（京都）	第85回日本薬理学会年会（京都）		2013/03		Japanese	Summary of the papers read (national conference and other science council)	Disclose to all
清水孝彦　他	清水孝彦　他		細胞質局在型SODの減少はアミロイドβオリゴマー形成と記憶障害を促進する	細胞質局在型SODの減少はアミロイドβオリゴマー形成と記憶障害を促進する		第35回日本分子生物学会年会（福岡）	第35回日本分子生物学会年会（福岡）		2012/12		Japanese	Summary of the papers read (national conference and other science council)	Disclose to all
M. Sato et al.	M. Sato et al.	M. Sato et al.	Specific inhibitory mechanism of aggregation of 42-mer amyloid-β peptide by flavonoids	Specific inhibitory mechanism of aggregation of 42-mer amyloid-β peptide by flavonoids	Specific inhibitory mechanism of aggregation of 42-mer amyloid-β peptide by flavonoids	The 12th International Kyoto Conference on New Aspects of Organic Chemistry (Kyoto, Japan)	The 12th International Kyoto Conference on New Aspects of Organic Chemistry (Kyoto, Japan)	The 12th International Kyoto Conference on New Aspects of Organic Chemistry (Kyoto, Japan)	2012/11	Refereed	English	Summary of the papers read (international conference)	Disclose to all
Y. Masuda et al.	Y. Masuda et al.	Y. Masuda et al.	Solid-state NMR analysis of interaction sites of curcumin and amyloid β-protein fibrils	Solid-state NMR analysis of interaction sites of curcumin and amyloid β-protein fibrils	Solid-state NMR analysis of interaction sites of curcumin and amyloid β-protein fibrils	The 12th International Kyoto Conference on New Aspects of Organic Chemistry (Kyoto, Japan)	The 12th International Kyoto Conference on New Aspects of Organic Chemistry (Kyoto, Japan)	The 12th International Kyoto Conference on New Aspects of Organic Chemistry (Kyoto, Japan)	2012/11	Refereed	English	Summary of the papers read (international conference)	Disclose to all
繁森英幸　他	繁森英幸　他		干しいもに含まれるカフェオイルキナ酸のアルツハイマー症予防効果	干しいもに含まれるカフェオイルキナ酸のアルツハイマー症予防効果		第23回日本化学会関東支部茨城地区研究交流会（日立）	第23回日本化学会関東支部茨城地区研究交流会（日立）		2012/11		Japanese	Summary of the papers read (national conference and other science council)	Disclose to all
村上一馬　他	村上一馬　他		アミロイドβオリゴマーの形成と空間記憶異常における細胞質SODの役割	アミロイドβオリゴマーの形成と空間記憶異常における細胞質SODの役割		第31回日本認知症学会学術集会	第31回日本認知症学会学術集会		2012/10		Japanese	Summary of the papers read (national conference and other science council)	Disclose to all
泉尾直孝　他	泉尾直孝　他		Aβ42の”毒性コンホマー”形成による細胞内酸化ストレスの誘導	Aβ42の”毒性コンホマー”形成による細胞内酸化ストレスの誘導		第31回日本認知症学会学術集会	第31回日本認知症学会学術集会		2012/10		Japanese	Summary of the papers read (national conference and other science council)	Disclose to all
村上一馬　他	村上一馬　他		カテコール系フラボノイド類によるアミロイドβの凝集抑制機構	カテコール系フラボノイド類によるアミロイドβの凝集抑制機構		第54回天然有機化合物討論会	第54回天然有機化合物討論会		2012/09	Refereed	Japanese	Summary of the papers read (national conference and other science council)	Disclose to all
菊森将之　他	菊森将之　他		Debromoaplysiatoxin単純化アナログの10位メチル体の合成と細胞増殖抑制活性	Debromoaplysiatoxin単純化アナログの10位メチル体の合成と細胞増殖抑制活性		2012年度日本農芸化学会関西支部大会（亀岡）	2012年度日本農芸化学会関西支部大会（亀岡）		2012/09		Japanese	Summary of the papers read (national conference and other science council)	Disclose to all
泉尾直孝　他	泉尾直孝　他		Aβ42 “毒性コンホマー”の形成は細胞内酸化ストレスを誘導する	Aβ42 “毒性コンホマー”の形成は細胞内酸化ストレスを誘導する		次世代を担う創薬・医療薬理シンポジウム 2012（神戸）	次世代を担う創薬・医療薬理シンポジウム 2012（神戸）		2012/09		Japanese	Summary of the papers read (national conference and other science council)	Disclose to all
K. Irie et al.	K. Irie et al.	K. Irie et al.	Monoclonal antibody against a toxic conformer of Aβ42 with a turn at E22-D23	Monoclonal antibody against a toxic conformer of Aβ42 with a turn at E22-D23	Monoclonal antibody against a toxic conformer of Aβ42 with a turn at E22-D23	Alzheimer's Association International Conference (AAIC) 2012 in Vancouver, British Columbia, Canada	Alzheimer's Association International Conference (AAIC) 2012 in Vancouver, British Columbia, Canada	Alzheimer's Association International Conference (AAIC) 2012 in Vancouver, British Columbia, Canada	2012/07	Refereed	English	Summary of the papers read (international conference)	Disclose to all
K. Murakami et al.	K. Murakami et al.	K. Murakami et al.	CuZn-SOD loss accelerates the formation of amyloid β oligomer and memory impairment in Tg2576 mice	CuZn-SOD loss accelerates the formation of amyloid β oligomer and memory impairment in Tg2576 mice	CuZn-SOD loss accelerates the formation of amyloid β oligomer and memory impairment in Tg2576 mice	Alzheimer's Association International Conference (AAIC) 2012 in Vancouver, British Columbia, Canada	Alzheimer's Association International Conference (AAIC) 2012 in Vancouver, British Columbia, Canada	Alzheimer's Association International Conference (AAIC) 2012 in Vancouver, British Columbia, Canada	2012/07	Refereed	English	Summary of the papers read (international conference)	Disclose to all
植野紗代　他	植野紗代　他		日本産フサコケムシに含まれるブリオスタチン類の同定と活性評価	日本産フサコケムシに含まれるブリオスタチン類の同定と活性評価		2012年度日本農芸化学会大会（京都）	2012年度日本農芸化学会大会（京都）		2012/03		Japanese	Summary of the papers read (national conference and other science council)	Disclose to all
朱裕姫　他	朱裕姫　他		抗腫瘍性Aplysiatoxin単純化アナログの側鎖の構造活性相関を目的とした合成経路の確立	抗腫瘍性Aplysiatoxin単純化アナログの側鎖の構造活性相関を目的とした合成経路の確立		2012年度日本農芸化学会大会（京都）	2012年度日本農芸化学会大会（京都）		2012/03		Japanese	Summary of the papers read (national conference and other science council)	Disclose to all
高橋正和　他	高橋正和　他		木田チリメンシソから単離したガラクトグリセロ脂質は食細胞においてO2－およびNOの産生を阻害する	木田チリメンシソから単離したガラクトグリセロ脂質は食細胞においてO2－およびNOの産生を阻害する		2012年度日本農芸化学会大会（京都）	2012年度日本農芸化学会大会（京都）		2012/03		Japanese	Summary of the papers read (national conference and other science council)	Disclose to all
石原紋子　他	石原紋子　他		ゲラニルトリプトファンの生合成に関する研究	ゲラニルトリプトファンの生合成に関する研究		2012年度日本農芸化学会大会（京都）	2012年度日本農芸化学会大会（京都）		2012/03		Japanese	Summary of the papers read (national conference and other science council)	Disclose to all
山崎梨沙　他	山崎梨沙　他		イソプレニル修飾酵素ComQのイソプレノイド選択性に関わるアミノ酸残基の同定	イソプレニル修飾酵素ComQのイソプレノイド選択性に関わるアミノ酸残基の同定		2012年度日本農芸化学会大会（京都）	2012年度日本農芸化学会大会（京都）		2012/03		Japanese	Summary of the papers read (national conference and other science council)	Disclose to all
栗栖真奈美	栗栖真奈美		ヤセウツボ (Orobanche minor) 由来化合物のアミロイドβ凝集阻害活性に関する研究	ヤセウツボ (Orobanche minor) 由来化合物のアミロイドβ凝集阻害活性に関する研究		2012年度日本農芸化学会大会（京都）	2012年度日本農芸化学会大会（京都）		2012/03		Japanese	Summary of the papers read (national conference and other science council)	Disclose to all
佐藤瑞穂　他	佐藤瑞穂　他		酸化型タキシフォリンによるアミロイド β の凝集抑制機構	酸化型タキシフォリンによるアミロイド β の凝集抑制機構		2012年度日本農芸化学会大会（京都）	2012年度日本農芸化学会大会（京都）		2012/03		Japanese	Summary of the papers read (national conference and other science council)	Disclose to all
村上一馬　他	村上一馬　他		細胞質酸化ストレスによるアミロイド β オリゴマー形成能および記憶異常の促進	細胞質酸化ストレスによるアミロイド β オリゴマー形成能および記憶異常の促進		2012年度日本農芸化学会大会（京都）	2012年度日本農芸化学会大会（京都）		2012/03		Japanese	Summary of the papers read (national conference and other science council)	Disclose to all
清水孝彦　他	清水孝彦　他		インスリン抵抗性による高インスリン血症はアルツハイマー病様症状を増悪しない	インスリン抵抗性による高インスリン血症はアルツハイマー病様症状を増悪しない		2012年度日本農芸化学会大会（京都）	2012年度日本農芸化学会大会（京都）		2012/03		Japanese	Summary of the papers read (national conference and other science council)	Disclose to all
奥田治子　他	奥田治子　他		Streptomyces blastmyceticus由来 (-)-indolactam V生合成遺伝子の放線菌における発現	Streptomyces blastmyceticus由来 (-)-indolactam V生合成遺伝子の放線菌における発現		2012年度日本農芸化学会大会（京都）	2012年度日本農芸化学会大会（京都）		2012/03		Japanese	Summary of the papers read (national conference and other science council)	Disclose to all
泉尾直孝　他	泉尾直孝　他		Crucial role of the turn at positions 22-23 in neurotoxicity of amyloid β	Crucial role of the turn at positions 22-23 in neurotoxicity of amyloid β	Crucial role of the turn at positions 22-23 in neurotoxicity of amyloid β	第85回日本薬理学会年会（京都）	第85回日本薬理学会年会（京都）		2012/03		Japanese	Summary of the papers read (national conference and other science council)	Disclose to all
Yusuke Ozawa et al.	Yusuke Ozawa et al.		Insulin receptor mutation results in insulin resistance and hyper insulinemia but does not worsen Alzheimer's-like phenotypes in mice	Insulin receptor mutation results in insulin resistance and hyper insulinemia but does not worsen Alzheimer's-like phenotypes in mice		The 34th Annual Meeting of the Molecular Biology Society of Japan (Yokohama)	The 34th Annual Meeting of the Molecular Biology Society of Japan (Yokohama)		2011/12		Japanese	Summary of the papers read (national conference and other science council)	Disclose to all
平林智美　他	平林智美　他		気孔形成を調節するペプチドホルモンの機能解析	気孔形成を調節するペプチドホルモンの機能解析		第46回植物化学調節学会（宇都宮）	第46回植物化学調節学会（宇都宮）		2011/11		Japanese	Summary of the papers read (national conference and other science council)	Disclose to all
村上一馬　他	村上一馬　他		抗酸化ストレスに着目したアルツハイマー病予防の可能性	抗酸化ストレスに着目したアルツハイマー病予防の可能性		原子炉実験所専門研究会（熊取）	原子炉実験所専門研究会（熊取）		2011/11		Japanese	Summary of the papers read (national conference and other science council)	Disclose to all
村上一馬　他	村上一馬　他		大阪変異によるアミロイドβの毒性コンホマー形成能の増大	大阪変異によるアミロイドβの毒性コンホマー形成能の増大		第30回日本認知症学会学術集会（東京）	第30回日本認知症学会学術集会（東京）		2011/11		Japanese	Summary of the papers read (national conference and other science council)	Disclose to all
松村敦子　他	松村敦子　他		Nrf2-ARE経路活性化作用を有する食品由来成分の探索	Nrf2-ARE経路活性化作用を有する食品由来成分の探索		第120回日本薬理学会近畿部会（京都）	第120回日本薬理学会近畿部会（京都）		2011/11		Japanese	Summary of the papers read (national conference and other science council)	Disclose to all
Takuji Shirasawa et al.	Takuji Shirasawa et al.	Takuji Shirasawa et al.	Insulin receptor mutation results in insulin resistance and hyperinsulinemia but does not worsen Alzheimer’s-like phenotypes in mice	Insulin receptor mutation results in insulin resistance and hyperinsulinemia but does not worsen Alzheimer’s-like phenotypes in mice	Insulin receptor mutation results in insulin resistance and hyperinsulinemia but does not worsen Alzheimer’s-like phenotypes in mice	41st Annual Meeting of Society for Neuroscience (Washington DC, USA)	41st Annual Meeting of Society for Neuroscience (Washington DC, USA)	41st Annual Meeting of Society for Neuroscience (Washington DC, USA)	2011/11		English	Summary of the papers read (international conference)	Disclose to all
Takahiko Shimizu et al.	Takahiko Shimizu et al.	Takahiko Shimizu et al.	Silymarin attenuated the amyloid β deposition and behavioral abnormalities in a mouse model of Alzheimer’s disease	Silymarin attenuated the amyloid β deposition and behavioral abnormalities in a mouse model of Alzheimer’s disease	Silymarin attenuated the amyloid β deposition and behavioral abnormalities in a mouse model of Alzheimer’s disease	41st Annual Meeting of Society for Neuroscience (Washington DC, USA)	41st Annual Meeting of Society for Neuroscience (Washington DC, USA)	41st Annual Meeting of Society for Neuroscience (Washington DC, USA)	2011/11		English	Summary of the papers read (international conference)	Disclose to all
佐藤瑞穂　他	佐藤瑞穂　他		タキシフォリンによるアミロイドβの凝集抑制機構	タキシフォリンによるアミロイドβの凝集抑制機構		2011年度日本農芸化学会関西・中部支部合同大会（京都）	2011年度日本農芸化学会関西・中部支部合同大会（京都）		2011/10		Japanese	Summary of the papers read (national conference and other science council)	Disclose to all
増田裕一　他	増田裕一　他		アミロイドβ凝集体におけるクルクミンの相互作用部位の固体NMRによる解析	アミロイドβ凝集体におけるクルクミンの相互作用部位の固体NMRによる解析		化学系学協会東北大会（仙台）	化学系学協会東北大会（仙台）		2011/09		Japanese	Summary of the papers read (national conference and other science council)	Disclose to all
宮前友策　他	宮前友策　他		カフェオイルキナ酸のアミロイドβ凝集阻害活性及び分子機構	カフェオイルキナ酸のアミロイドβ凝集阻害活性及び分子機構		第53回天然有機化合物討論会（大阪）	第53回天然有機化合物討論会（大阪）		2011/09	Refereed	Japanese	Summary of the papers read (national conference and other science council)	Disclose to all
泉尾直孝　他	泉尾直孝　他		変異体を用いたAβ誘発神経毒性におけるターン構造の重要性の検討	変異体を用いたAβ誘発神経毒性におけるターン構造の重要性の検討		第119回日本薬理学会近畿部会（名古屋）	第119回日本薬理学会近畿部会（名古屋）		2011/07		Japanese	Summary of the papers read (national conference and other science council)	Disclose to all
Kazuma Murakami et al.	Kazuma Murakami et al.	Kazuma Murakami et al.	E22Δ mutation promotes the formation of toxic conformer in Alzheimer's peptide, Aβ42	E22Δ mutation promotes the formation of toxic conformer in Alzheimer's peptide, Aβ42	E22Δ mutation promotes the formation of toxic conformer in Alzheimer's peptide, Aβ42	27th International Symposium on the Chemistry of Natural Products, 7th International Conference on Biodiversity (Brisbane, Australia)	27th International Symposium on the Chemistry of Natural Products, 7th International Conference on Biodiversity (Brisbane, Australia)	27th International Symposium on the Chemistry of Natural Products, 7th International Conference on Biodiversity (Brisbane, Australia)	2011/07		English	Summary of the papers read (international conference)	Disclose to all
Mizuho Sato et al.	Mizuho Sato et al.	Mizuho Sato et al.	Inhibitory mechanism of amyloid β aggregation by flavonoids	Inhibitory mechanism of amyloid β aggregation by flavonoids	Inhibitory mechanism of amyloid β aggregation by flavonoids	27th International Symposium on the Chemistry of Natural Products, 7th International Conference on Biodiversity (Brisbane, Australia)	27th International Symposium on the Chemistry of Natural Products, 7th International Conference on Biodiversity (Brisbane, Australia)	27th International Symposium on the Chemistry of Natural Products, 7th International Conference on Biodiversity (Brisbane, Australia)	2011/07		English	Summary of the papers read (international conference)	Disclose to all
菊森将之　他	菊森将之　他		Aplysiatoxin単純化アナログの4位メチル体の各種生物活性	Aplysiatoxin単純化アナログの4位メチル体の各種生物活性		2011年度日本農芸化学会大会（京都）	2011年度日本農芸化学会大会（京都）		2011/03		Japanese	Summary of the papers read (national conference and other science council)	Disclose to all
土井崇嗣　他	土井崇嗣　他		アミロイド β オリゴマーの固体NMRによる立体構造解析	アミロイド β オリゴマーの固体NMRによる立体構造解析		2011年度日本農芸化学会大会（京都）	2011年度日本農芸化学会大会（京都）		2011/03		Japanese	Summary of the papers read (national conference and other science council)	Disclose to all
中村志織　他	中村志織　他		ホウレンソウに含まれるNO産生抑制物質	ホウレンソウに含まれるNO産生抑制物質		2011年度日本農芸化学会大会（京都）	2011年度日本農芸化学会大会（京都）		2011/03		Japanese	Summary of the papers read (national conference and other science council)	Disclose to all
清水孝彦　他	清水孝彦　他		アルツハイマー病モデルマウスに対するsilymarinの予防効果	アルツハイマー病モデルマウスに対するsilymarinの予防効果		2011年度日本農芸化学会大会（京都）	2011年度日本農芸化学会大会（京都）		2011/03		Japanese	Summary of the papers read (national conference and other science council)	Disclose to all
柳田　亮　他	柳田　亮　他		抗腫瘍性PKC活性化剤Aplog-1の生物活性におけるフェノール性水酸基の役割	抗腫瘍性PKC活性化剤Aplog-1の生物活性におけるフェノール性水酸基の役割		2011年度日本農芸化学会大会（京都）	2011年度日本農芸化学会大会（京都）		2011/03		Japanese	Summary of the papers read (national conference and other science council)	Disclose to all
村上一馬　他	村上一馬　他		アミロイドβのGlu22欠損による毒性コンホマー形成能の促進	アミロイドβのGlu22欠損による毒性コンホマー形成能の促進		2011年度日本農芸化学会大会（京都）	2011年度日本農芸化学会大会（京都）		2011/03		Japanese	Summary of the papers read (national conference and other science council)	Disclose to all
佐藤瑞穂　他	佐藤瑞穂　他		アミロイドβ凝集阻害物質Taxifolinの13C標識化	アミロイドβ凝集阻害物質Taxifolinの13C標識化		2011年度日本農芸化学会大会（京都）	2011年度日本農芸化学会大会（京都）		2011/03		Japanese	Summary of the papers read (national conference and other science council)	Disclose to all
杉山友太　他	杉山友太　他		ナツメに含まれるNO産生抑制成分の単離・同定と作用機序解析	ナツメに含まれるNO産生抑制成分の単離・同定と作用機序解析		2011年度日本農芸化学会大会（京都）	2011年度日本農芸化学会大会（京都）		2011/03		Japanese	Summary of the papers read (national conference and other science council)	Disclose to all
Fumitada Tsuji et al.	Fumitada Tsuji et al.	Fumitada Tsuji et al.	Geranyl modification on the tryptophan residue of ComXRO-E-2 pheromone by cell free system	Geranyl modification on the tryptophan residue of ComXRO-E-2 pheromone by cell free system	Geranyl modification on the tryptophan residue of ComXRO-E-2 pheromone by cell free system	2010 International Chemical Congress of Pacific Basin Societies (PACIFICHEM 2010) (Hawaii, USA)	2010 International Chemical Congress of Pacific Basin Societies (PACIFICHEM 2010) (Hawaii, USA)	2010 International Chemical Congress of Pacific Basin Societies (PACIFICHEM 2010) (Hawaii, USA)	2010/12	Refereed	English	Summary of the papers read (international conference)	Disclose to all
Kazuhiro Irie et al.	Kazuhiro Irie et al.	Kazuhiro Irie et al.	Synthesis and biological profile of simple analogues of tumor-promoting aplysiatoxin as unique leads for anti-cancer drugs	Synthesis and biological profile of simple analogues of tumor-promoting aplysiatoxin as unique leads for anti-cancer drugs	Synthesis and biological profile of simple analogues of tumor-promoting aplysiatoxin as unique leads for anti-cancer drugs	2010 International Chemical Congress of Pacific Basin Societies (PACIFICHEM 2010) (Hawaii, USA)	2010 International Chemical Congress of Pacific Basin Societies (PACIFICHEM 2010) (Hawaii, USA)	2010 International Chemical Congress of Pacific Basin Societies (PACIFICHEM 2010) (Hawaii, USA)	2010/12	Refereed	English	Summary of the papers read (international conference)	Disclose to all
Ryo C. Yanagita et al.	Ryo C. Yanagita et al.	Ryo C. Yanagita et al.	Screening for activators of protein kinase C using its C1 domain peptide: identification and biological activities of bryostatin 10 from Japanese bryozoan	Screening for activators of protein kinase C using its C1 domain peptide: identification and biological activities of bryostatin 10 from Japanese bryozoan	Screening for activators of protein kinase C using its C1 domain peptide: identification and biological activities of bryostatin 10 from Japanese bryozoan	2010 International Chemical Congress of Pacific Basin Societies (PACIFICHEM 2010) (Hawaii, USA)	2010 International Chemical Congress of Pacific Basin Societies (PACIFICHEM 2010) (Hawaii, USA)	2010 International Chemical Congress of Pacific Basin Societies (PACIFICHEM 2010) (Hawaii, USA)	2010/12	Refereed	English	Summary of the papers read (international conference)	Disclose to all
Kazuma Murakami et al.	Kazuma Murakami et al.	Kazuma Murakami et al.	Monoclonal antibody against the toxic turn structure of the 42-mer amyloid β peptide	Monoclonal antibody against the toxic turn structure of the 42-mer amyloid β peptide	Monoclonal antibody against the toxic turn structure of the 42-mer amyloid β peptide	2010 International Chemical Congress of Pacific Basin Societies (PACIFICHEM 2010) (Hawaii, USA)	2010 International Chemical Congress of Pacific Basin Societies (PACIFICHEM 2010) (Hawaii, USA)	2010 International Chemical Congress of Pacific Basin Societies (PACIFICHEM 2010) (Hawaii, USA)	2010/12	Refereed	English	Summary of the papers read (international conference)	Disclose to all
Yuichi Masuda et al.	Yuichi Masuda et al.	Yuichi Masuda et al.	Analysis of interaction sites of curcumin with the fibrils of 42-residue amyloid β-protein (Aβ42) using solid-state NMR	Analysis of interaction sites of curcumin with the fibrils of 42-residue amyloid β-protein (Aβ42) using solid-state NMR	Analysis of interaction sites of curcumin with the fibrils of 42-residue amyloid β-protein (Aβ42) using solid-state NMR	2010 International Chemical Congress of Pacific Basin Societies (PACIFICHEM 2010) (Hawaii, USA)	2010 International Chemical Congress of Pacific Basin Societies (PACIFICHEM 2010) (Hawaii, USA)	2010 International Chemical Congress of Pacific Basin Societies (PACIFICHEM 2010) (Hawaii, USA)	2010/12		English	Summary of the papers read (international conference)	Disclose to all
村上一馬　他	村上一馬　他		アミロイドβ (Aβ42) の毒性コンホマー特異的抗体の作製	アミロイドβ (Aβ42) の毒性コンホマー特異的抗体の作製		第52回天然有機化合物討論会（静岡）［討論会奨励賞受賞］	第52回天然有機化合物討論会（静岡）［討論会奨励賞受賞］		2010/09	Refereed	Japanese	Summary of the papers read (national conference and other science council)	Disclose to all
Yuichi Masuda et al.	Yuichi Masuda et al.	Yuichi Masuda et al.	Analysis of binding sites of curcumin in the fibrils of 42-residue amyloid β-protein (Aβ42) using solid-state NMR	Analysis of binding sites of curcumin in the fibrils of 42-residue amyloid β-protein (Aβ42) using solid-state NMR	Analysis of binding sites of curcumin in the fibrils of 42-residue amyloid β-protein (Aβ42) using solid-state NMR	The 51st Experimental Nuclear Magnetic Resonance Conference (Florida, USA)	The 51st Experimental Nuclear Magnetic Resonance Conference (Florida, USA)	The 51st Experimental Nuclear Magnetic Resonance Conference (Florida, USA)	2010		English	Summary of the papers read (international conference)	Disclose to all
村上一馬　他	村上一馬　他		アミロイドβの毒性ターン構造特異的抗体	アミロイドβの毒性ターン構造特異的抗体		第29回日本認知症学会学術集会（名古屋）	第29回日本認知症学会学術集会（名古屋）		2010		Japanese	Summary of the papers read (national conference and other science council)	Disclose to all
菊森将之　他	菊森将之　他		抗腫瘍性aplysiatoxin誘導体の4位メチル体の合成と生物活性	抗腫瘍性aplysiatoxin誘導体の4位メチル体の合成と生物活性		2010年度日本農芸化学会関西支部大会（奈良）	2010年度日本農芸化学会関西支部大会（奈良）		2010		Japanese	Summary of the papers read (national conference and other science council)	Disclose to all
柳田　亮　他	柳田　亮　他		抗腫瘍性Aplysiatoxin誘導体の18位ヒドロキシル基の生物活性に与える影響	抗腫瘍性Aplysiatoxin誘導体の18位ヒドロキシル基の生物活性に与える影響		第45回天然物化学談話会（蒲郡）	第45回天然物化学談話会（蒲郡）		2010		Japanese	Summary of the papers read (national conference and other science council)	Disclose to all
土井崇嗣　他	土井崇嗣　他		アミロイドβプロトフィブリルの固体NMRによる立体構造解析	アミロイドβプロトフィブリルの固体NMRによる立体構造解析		第49回NMR討論会（東京）	第49回NMR討論会（東京）		2010		Japanese	Summary of the papers read (national conference and other science council)	Disclose to all
田中啓介　他	田中啓介　他		抗腫瘍性PKC活性化剤Aplog-1の生物活性における芳香環部分の置換基効果	抗腫瘍性PKC活性化剤Aplog-1の生物活性における芳香環部分の置換基効果		2010年度日本農芸化学会大会（東京）	2010年度日本農芸化学会大会（東京）		2009		Japanese	Summary of the papers read (national conference and other science council)	Disclose to all
柳田　亮　他	柳田　亮　他		抗腫瘍性アプリシアトキシン誘導体の作用機構の解析	抗腫瘍性アプリシアトキシン誘導体の作用機構の解析		第44回天然物化学談話会（つくば）	第44回天然物化学談話会（つくば）		2009		Japanese	Summary of the papers read (national conference and other science council)	Disclose to all
中川　優　他	中川　優　他		アプリシアトキシンの骨格を有する抗腫瘍性PKC活性化剤のアナログ合成	アプリシアトキシンの骨格を有する抗腫瘍性PKC活性化剤のアナログ合成		第57回有機合成化学協会関東支部シンポシウム（東京）	第57回有機合成化学協会関東支部シンポシウム（東京）		2009		Japanese	Summary of the papers read (national conference and other science council)	Disclose to all
Nakaba Murata et al.	Nakaba Murata et al.		Silymarin inhibits fibril formation and neurotoxicity of amyloid β peptide	Silymarin inhibits fibril formation and neurotoxicity of amyloid β peptide		第32回日本分子生物学会年会（横浜）	第32回日本分子生物学会年会（横浜）		2009		Japanese	Summary of the papers read (national conference and other science council)	Disclose to all
柳田　亮　他	柳田　亮　他		海洋動物に含まれる PKC 活性化剤の探索および活性評価	海洋動物に含まれる PKC 活性化剤の探索および活性評価		2010年度日本農芸化学会大会（東京）	2010年度日本農芸化学会大会（東京）		2009		Japanese	Summary of the papers read (national conference and other science council)	Disclose to all
増田裕一　他	増田裕一　他		Aβ42凝集体におけるクルクミン結合部位の固体NMRによる解析	Aβ42凝集体におけるクルクミン結合部位の固体NMRによる解析		2010年度日本農芸化学会大会（東京）	2010年度日本農芸化学会大会（東京）		2009		Japanese	Summary of the papers read (national conference and other science council)	Disclose to all
近藤竜彦　他	近藤竜彦　他		植物の気孔形成を誘導するペプチド性因子の構造と生理活性	植物の気孔形成を誘導するペプチド性因子の構造と生理活性		2010年度日本農芸化学会大会（東京）	2010年度日本農芸化学会大会（東京）		2009		Japanese	Summary of the papers read (national conference and other science council)	Disclose to all
中川　優　他	中川　優　他		抗腫瘍性aplysiatoxinアナログ・Aplog-1の12-ジメチル体の合成と生物活性	抗腫瘍性aplysiatoxinアナログ・Aplog-1の12-ジメチル体の合成と生物活性		2010年度日本農芸化学会大会（東京）	2010年度日本農芸化学会大会（東京）		2009		Japanese	Summary of the papers read (national conference and other science council)	Disclose to all
村上一馬　他	村上一馬　他		アミロイドβの毒性コンホマーを標的とした立体構造特異的抗体	アミロイドβの毒性コンホマーを標的とした立体構造特異的抗体		2010年度日本農芸化学会大会（東京）［トピックス賞］	2010年度日本農芸化学会大会（東京）［トピックス賞］		2009		Japanese	Summary of the papers read (national conference and other science council)	Disclose to all
Ryo C. Yanagita et al.	Ryo C. Yanagita et al.	Ryo C. Yanagita et al.	Structure-activity relationship study of an antineoplastic protein kinase C activator having a skeleton of tumor-promoting aplysiatoxin	Structure-activity relationship study of an antineoplastic protein kinase C activator having a skeleton of tumor-promoting aplysiatoxin	Structure-activity relationship study of an antineoplastic protein kinase C activator having a skeleton of tumor-promoting aplysiatoxin	The 11th International Kyoto Conference on New Aspects of Organic Chemistry (Kyoto, Japan)	The 11th International Kyoto Conference on New Aspects of Organic Chemistry (Kyoto, Japan)	The 11th International Kyoto Conference on New Aspects of Organic Chemistry (Kyoto, Japan)	2009		English	Summary of the papers read (international conference)	Disclose to all
Kazuma Murakami et al.	Kazuma Murakami et al.	Kazuma Murakami et al.	Development of a monoclonal antibody against the toxic conformer of the 42-mer amyloid β protein	Development of a monoclonal antibody against the toxic conformer of the 42-mer amyloid β protein	Development of a monoclonal antibody against the toxic conformer of the 42-mer amyloid β protein	39th Annual Meeting of Society for Neuroscience (Chicago, USA)	39th Annual Meeting of Society for Neuroscience (Chicago, USA)	39th Annual Meeting of Society for Neuroscience (Chicago, USA)	2009		English	Summary of the papers read (international conference)	Disclose to all
Hideyuki Takahashi et al.	Hideyuki Takahashi et al.	Hideyuki Takahashi et al.	Spinocerebellar ataxia type 14-associated mutations in protein kinase Cgamma cause its aberrant self-association and cytotoxic aggregate formation	Spinocerebellar ataxia type 14-associated mutations in protein kinase Cgamma cause its aberrant self-association and cytotoxic aggregate formation	Spinocerebellar ataxia type 14-associated mutations in protein kinase Cgamma cause its aberrant self-association and cytotoxic aggregate formation	Keystone Symposia on Neurodegenerative Diseases: New Molecular Mechanisms (Colorado, USA)	Keystone Symposia on Neurodegenerative Diseases: New Molecular Mechanisms (Colorado, USA)	Keystone Symposia on Neurodegenerative Diseases: New Molecular Mechanisms (Colorado, USA)	2008		English	Summary of the papers read (international conference)	Disclose to all
古川博史　他	古川博史　他		Streptomyces blastmyceticus 由来 teleocidin 生合成遺伝子群に存在する tcnBおよび tcnC の機能	Streptomyces blastmyceticus 由来 teleocidin 生合成遺伝子群に存在する tcnBおよび tcnC の機能		第60回日本生物工学会大会（仙台）	第60回日本生物工学会大会（仙台）		2008		Japanese	Summary of the papers read (national conference and other science council)	Disclose to all
入江一浩　他	入江一浩　他		β アミロイドの毒性コンホメーションのESRならびに固体NMRによる検証	β アミロイドの毒性コンホメーションのESRならびに固体NMRによる検証		第27回日本認知症学会集会（前橋）	第27回日本認知症学会集会（前橋）		2008		Japanese	Summary of the papers read (national conference and other science council)	Disclose to all
増田裕一　他	増田裕一　他		βアミロイドの毒性コンホメーションの同定	βアミロイドの毒性コンホメーションの同定		第45回ペプチド討論会（東京）	第45回ペプチド討論会（東京）		2008	Refereed	Japanese	Summary of the papers read (national conference and other science council)	Disclose to all
Kazuma Murakami et al.	Kazuma Murakami et al.	Kazuma Murakami et al.	Isomerization and/or racemization at Asp23 of Aβ42 do not enhance its aggregation, neurotoxicity, and radical productivity in vitro	Isomerization and/or racemization at Asp23 of Aβ42 do not enhance its aggregation, neurotoxicity, and radical productivity in vitro	Isomerization and/or racemization at Asp23 of Aβ42 do not enhance its aggregation, neurotoxicity, and radical productivity in vitro	38th Annual Meeting of Society for Neuroscience (Washington DC, USA)	38th Annual Meeting of Society for Neuroscience (Washington DC, USA)	38th Annual Meeting of Society for Neuroscience (Washington DC, USA)	2008		English	Summary of the papers read (international conference)	Disclose to all
村上一馬　他	村上一馬　他		アミロイド β のAsp23における異性化あるいはラセミ化が凝集能および神経細胞毒性に及ぼす影響	アミロイド β のAsp23における異性化あるいはラセミ化が凝集能および神経細胞毒性に及ぼす影響		2009年度日本農芸化学会大会（博多）	2009年度日本農芸化学会大会（博多）		2008		Japanese	Summary of the papers read (national conference and other science council)	Disclose to all
宇野真弓　他	宇野真弓　他		酸化型タキシフォリンのアミロイドβ凝集阻害活性	酸化型タキシフォリンのアミロイドβ凝集阻害活性		2009年度日本農芸化学会大会（博多）	2009年度日本農芸化学会大会（博多）		2008		Japanese	Summary of the papers read (national conference and other science council)	Disclose to all
古川博史　他	古川博史　他		Streptomyces blastmyceticum由来teleocidin生合成遺伝子群に存在するtcnB、TcnCの機能に関する研究	Streptomyces blastmyceticum由来teleocidin生合成遺伝子群に存在するtcnB、TcnCの機能に関する研究		2009年度日本農芸化学会大会（博多）	2009年度日本農芸化学会大会（博多）		2008		Japanese	Summary of the papers read (national conference and other science council)	Disclose to all
増田裕一　他	増田裕一　他		βアミロイド凝集体に存在する毒性コンホメーションの同定	βアミロイド凝集体に存在する毒性コンホメーションの同定		第27回日本認知症学会集会（前橋）	第27回日本認知症学会集会（前橋）		2008		Japanese	Summary of the papers read (national conference and other science council)	Disclose to all
村上一馬　他	村上一馬　他		アミロイド β ペプチド (Aβ42) の病的コンホメーションの提唱	アミロイド β ペプチド (Aβ42) の病的コンホメーションの提唱		日本基礎老化学会第31回大会（松本）	日本基礎老化学会第31回大会（松本）		2008		Japanese	Summary of the papers read (national conference and other science council)	Disclose to all
中川　優　他	中川　優　他		天然発がんプロモーターの骨格を利用した抗がん剤bryostatin等価体の開発	天然発がんプロモーターの骨格を利用した抗がん剤bryostatin等価体の開発		第50回天然有機化合物討論会（福岡）	第50回天然有機化合物討論会（福岡）		2008	Refereed	Japanese	Summary of the papers read (national conference and other science council)	Disclose to all
増田裕一　他	増田裕一　他		βアミロイド凝集体のC末端における分子内βシート構造の固体NMRによる検証	βアミロイド凝集体のC末端における分子内βシート構造の固体NMRによる検証		第43回天然物化学談話会（大阪）	第43回天然物化学談話会（大阪）		2008		Japanese	Summary of the papers read (national conference and other science council)	Disclose to all
辻　史忠　他	辻　史忠　他		酵素反応系を利用したComXRO-E-2フェロモンのゲラニル修飾の検出	酵素反応系を利用したComXRO-E-2フェロモンのゲラニル修飾の検出		2009年度日本農芸化学会大会（博多）	2009年度日本農芸化学会大会（博多）		2008		Japanese	Summary of the papers read (national conference and other science council)	Disclose to all
増田裕一　他	増田裕一　他		Aβ42凝集体のC末端における分子内β-シート構造の固体NMRによる検証	Aβ42凝集体のC末端における分子内β-シート構造の固体NMRによる検証		2009年度日本農芸化学会大会（博多）	2009年度日本農芸化学会大会（博多）		2008		Japanese	Summary of the papers read (national conference and other science council)	Disclose to all
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Conference Activities & Talks

Title	Title(Japanese)	Title(English)	Conference	Conference(Japanese)	Conference(English)	Promotor	Promotor(Japanese)	Promotor(English)	Date	Language	Assortment	Disclose
アミロイドβの毒性を示す立体構造の同定とアルツハイマー病診断への応用[Invited]	アミロイドβの毒性を示す立体構造の同定とアルツハイマー病診断への応用 [Invited]	アミロイドβの毒性を示す立体構造の同定とアルツハイマー病診断への応用 [Invited]	第125回　支援センターセミナー（滋賀医科大学）	第125回　支援センターセミナー（滋賀医科大学）	第125回　支援センターセミナー（滋賀医科大学）	実験実習支援センター、神経難病研究センター	実験実習支援センター、神経難病研究センター		2018/05/15	Japanese	Public discourse, seminar, tutorial, course, lecture and others	Disclose to all
Development of monoclonal antibody with specificity for a toxic conformer of amyloid β and its application toward the Alzheimer’s disease diagnosis and therapeutics[Invited]	Development of monoclonal antibody with specificity for a toxic conformer of amyloid β and its application toward the Alzheimer’s disease diagnosis and therapeutics [Invited]	Development of monoclonal antibody with specificity for a toxic conformer of amyloid β and its application toward the Alzheimer’s disease diagnosis and therapeutics [Invited]	Seminar in The Florey Institute, The University of Melbourne, Australia	Seminar in The Florey Institute, The University of Melbourne, Australia	Seminar in The Florey Institute, The University of Melbourne, Australia				2018/02/20	English	Oral presentation(invited, special)	Disclose to all
アプリシアトキシン単純化アナログ・10-Me-Aplog-1の構造最適化とがん細胞増殖抑制に関わるPKCアイソザイムの同定[Invited]	アプリシアトキシン単純化アナログ・10-Me-Aplog-1の構造最適化とがん細胞増殖抑制に関わるPKCアイソザイムの同定 [Invited]	アプリシアトキシン単純化アナログ・10-Me-Aplog-1の構造最適化とがん細胞増殖抑制に関わるPKCアイソザイムの同定 [Invited]	新学術領域研究「化学コミュニケーションのフロンティア」第2回公開シンポジウム（京都大学益川ホール、京都市）	新学術領域研究「化学コミュニケーションのフロンティア」第2回公開シンポジウム（京都大学益川ホール、京都市）	新学術領域研究「化学コミュニケーションのフロンティア」第2回公開シンポジウム（京都大学益川ホール、京都市）	新学術領域研究「化学コミュニケーションのフロンティア」総括班	新学術領域研究「化学コミュニケーションのフロンティア」総括班	新学術領域研究「化学コミュニケーションのフロンティア」総括班	2018/02/02	Japanese	Oral presentation(invited, special)	Disclose to all
アミロイドβの毒性2量体モデルの合成とイオンモビリティー質量分析法による構造解析[Invited]	アミロイドβの毒性2量体モデルの合成とイオンモビリティー質量分析法による構造解析 [Invited]	アミロイドβの毒性2量体モデルの合成とイオンモビリティー質量分析法による構造解析 [Invited]	京都大学学際融合教育研究推進センター・生理化学研究ユニット第7回公開シンポジウム（京都大学益川ホール、京都市）	京都大学学際融合教育研究推進センター・生理化学研究ユニット第7回公開シンポジウム（京都大学益川ホール、京都市）	京都大学学際融合教育研究推進センター・生理化学研究ユニット第7回公開シンポジウム（京都大学益川ホール、京都市）	京都大学学際融合教育研究推進センター	京都大学学際融合教育研究推進センター	京都大学学際融合教育研究推進センター	2017/12/22	Japanese	Oral presentation(invited, special)	Disclose to all
化学的手法に基づくアルツハイマー病の新しい予防戦略[Invited]	化学的手法に基づくアルツハイマー病の新しい予防戦略 [Invited]	化学的手法に基づくアルツハイマー病の新しい予防戦略 [Invited]	グローバルサイエンスキャンパス京都大学（ELCAS2017）基盤コース	グローバルサイエンスキャンパス京都大学（ELCAS2017）基盤コース	グローバルサイエンスキャンパス京都大学（ELCAS2017）基盤コース	京都大学　学際融合教育研究推進センター　高大接続科学教育ユニット	京都大学　学際融合教育研究推進センター　高大接続科学教育ユニット	京都大学　学際融合教育研究推進センター　高大接続科学教育ユニット	2017/10/07	Japanese	Public discourse, seminar, tutorial, course, lecture and others	Disclose to all
Measurements of toxic oligomers of amyloid β by ion mobility–mass spectrometry[Invited]	Measurements of toxic oligomers of amyloid β by ion mobility–mass spectrometry [Invited]	Measurements of toxic oligomers of amyloid β by ion mobility–mass spectrometry [Invited]	第65回質量分析総合討論会	第65回質量分析総合討論会	第65回質量分析総合討論会	The Mass Spectrometry Society of Japan	日本質量分析学会	The Mass Spectrometry Society of Japan	2017/05/18	Japanese	Oral presentation(invited, special)	Disclose to all
化学的手法に基づくアルツハイマー病の新しい予防戦略[Invited]	化学的手法に基づくアルツハイマー病の新しい予防戦略 [Invited]	化学的手法に基づくアルツハイマー病の新しい予防戦略 [Invited]	グローバルサイエンスキャンパス京都大学（ELCAS2016）基盤コース	グローバルサイエンスキャンパス京都大学（ELCAS2016）基盤コース	グローバルサイエンスキャンパス京都大学（ELCAS2016）基盤コース	京都大学　学際融合教育研究推進センター　高大接続科学教育ユニット	京都大学　学際融合教育研究推進センター　高大接続科学教育ユニット	京都大学　学際融合教育研究推進センター　高大接続科学教育ユニット	2016/10/01	Japanese	Public discourse, seminar, tutorial, course, lecture and others	Disclose to all
抗がん剤開発を指向した新規PKCリガンドの創製と作用機構解析[Invited]	抗がん剤開発を指向した新規PKCリガンドの創製と作用機構解析 [Invited]	抗がん剤開発を指向した新規PKCリガンドの創製と作用機構解析 [Invited]	新学術領域研究「天然物ケミカルバイオロジー」研究成果報告シンポジウム（慶應義塾大学日吉キャンパス、横浜市）	新学術領域研究「天然物ケミカルバイオロジー」研究成果報告シンポジウム（慶應義塾大学日吉キャンパス、横浜市）	新学術領域研究「天然物ケミカルバイオロジー」研究成果報告シンポジウム（慶應義塾大学日吉キャンパス、横浜市）	新学術領域研究「天然物ケミカルバイオロジー」総括班	新学術領域研究「天然物ケミカルバイオロジー」総括班		2016/07/01	Japanese	Oral presentation(invited, special)	Disclose to all
アプリシアトキシンの構造単純化による抗がん剤シーズの開発研究[Invited]	アプリシアトキシンの構造単純化による抗がん剤シーズの開発研究 [Invited]	アプリシアトキシンの構造単純化による抗がん剤シーズの開発研究 [Invited]	第33回メディシナルケミストリーシンポジウム	第33回メディシナルケミストリーシンポジウム	第33回メディシナルケミストリーシンポジウム	日本薬学会・医薬化学部会	日本薬学会・医薬化学部会	日本薬学会・医薬化学部会	2015/11/26	Japanese	Oral presentation(invited, special)	Disclose to all
化学的手法に基づくアルツハイマー病の新しい予防戦略[Invited]	化学的手法に基づくアルツハイマー病の新しい予防戦略 [Invited]	化学的手法に基づくアルツハイマー病の新しい予防戦略 [Invited]	グローバルサイエンスキャンパス京都大学（ELCAS 2015）基盤コース	グローバルサイエンスキャンパス京都大学（ELCAS 2015）基盤コース	グローバルサイエンスキャンパス京都大学（ELCAS 2015）基盤コース	京都大学　学際融合教育研究推進センター　高大接続科学教育ユニット	京都大学　学際融合教育研究推進センター　高大接続科学教育ユニット	京都大学　学際融合教育研究推進センター　高大接続科学教育ユニット	2015/10/17	Japanese	Public discourse, seminar, tutorial, course, lecture and others	Disclose to all
天然のプロテインキナーゼＣリガンドの単純化による抗がん剤シーズの開発研究[Invited]	天然のプロテインキナーゼＣリガンドの単純化による抗がん剤シーズの開発研究 [Invited]	天然のプロテインキナーゼＣリガンドの単純化による抗がん剤シーズの開発研究 [Invited]	の開発研究日本農芸化学会2015年度中四国・西日本支部合同大会（愛媛大学農学部・樽味キャンパス）	日本農芸化学会2015年度中四国・西日本支部合同大会（愛媛大学農学部・樽味キャンパス）	の開発研究日本農芸化学会2015年度中四国・西日本支部合同大会（愛媛大学農学部・樽味キャンパス）	日本農芸化学会中四国・西日本支部	日本農芸化学会中四国・西日本支部	日本農芸化学会中四国・西日本支部	2015/09/17	Japanese	Oral presentation(invited, special)	Disclose to all
Inhibitory mechanism for amyloid beta42 aggregation by flavonoids[Invited]	Inhibitory mechanism for amyloid beta42 aggregation by flavonoids [Invited]	Inhibitory mechanism for amyloid beta42 aggregation by flavonoids [Invited]	Kyoto-Bordeaux Symposium 2015	Kyoto-Bordeaux Symposium 2015	Kyoto-Bordeaux Symposium 2015	Kyoto University and University of Bordeaux	Kyoto University and University of Bordeaux	Kyoto University and University of Bordeaux	2015/05/22	English	Oral presentation(invited, special)	Disclose to all
化学を武器にアルツハイマー病に挑む[Invited]	化学を武器にアルツハイマー病に挑む [Invited]		関西大倉高校出前講義（高槻市）	関西大倉高校出前講義（高槻市）					2014/11/10	Japanese	Public discourse, seminar, tutorial, course, lecture and others	Disclose to all
抗がん剤開発を指向した新規プロテインキナーゼＣリガンドの創製[Invited]	抗がん剤開発を指向した新規プロテインキナーゼＣリガンドの創製 [Invited]		京都大学学際融合教育研究推進センター・生理化学研究ユニット・第４回シンポジウム	京都大学学際融合教育研究推進センター・生理化学研究ユニット・第４回シンポジウム		生理化学研究ユニット	生理化学研究ユニット		2014/06/24	Japanese	Oral presentation(invited, special)	Disclose to all
Synthesis and biological activities of the simplified analogs of a natural PKC ligand aplysiatoxin[Invited]	Synthesis and biological activities of the simplified analogs of a natural PKC ligand aplysiatoxin [Invited]	Synthesis and biological activities of the simplified analogs of a natural PKC ligand aplysiatoxin [Invited]	International Symposium on Natural Products Chemistry and Chemical Biology	International Symposium on Natural Products Chemistry and Chemical Biology	International Symposium on Natural Products Chemistry and Chemical Biology	JSPS, Asian CORE Program		JSPS, Asian CORE Program	2013/11/26	English	Oral presentation(invited, special)	Disclose to all
ポリフェノールによるアルツハイマー病予防の可能性[Invited]	ポリフェノールによるアルツハイマー病予防の可能性 [Invited]		数理分子セミナー	数理分子セミナー		広島大学理学研究科	広島大学理学研究科		2013/05/17	Japanese	Public discourse, seminar, tutorial, course, lecture and others	Disclose to all
ポリフェノールによるアミロイドβ の凝集抑制機構[Invited]	ポリフェノールによるアミロイドβ の凝集抑制機構 [Invited]		2013年度日本農芸化学会大会	2013年度日本農芸化学会大会		日本農芸化学会	日本農芸化学会		2013/03/27	Japanese	Oral presentation(invited, special)	Disclose to all
アミロイドβタンパクの毒性ターン構造の同定とその構造特異抗体の開発[Invited]	アミロイドβタンパクの毒性ターン構造の同定とその構造特異抗体の開発 [Invited]		第15回アグリバイオセミナー	第15回アグリバイオセミナー		近畿大学農学部	近畿大学農学部		2012/11/22	Japanese	Public discourse, seminar, tutorial, course, lecture and others	Disclose to all
Structure-activity studies on a simplified analog of debromoaplysiatoxin with anti-proliferative activity[Invited]	Structure-activity studies on a simplified analog of debromoaplysiatoxin with anti-proliferative activity [Invited]	Structure-activity studies on a simplified analog of debromoaplysiatoxin with anti-proliferative activity [Invited]	The 1st International Symposium on Chemical Biology of Natural Products: Target ID and Regulation of Bioactivity	The 1st International Symposium on Chemical Biology of Natural Products: Target ID and Regulation of Bioactivity	The 1st International Symposium on Chemical Biology of Natural Products: Target ID and Regulation of Bioactivity	Scientific Research on Innovative Areas, a MEXT Grant-in-Aid Project FY		Scientific Research on Innovative Areas, a MEXT Grant-in-Aid Project FY	2012/10/31	English	Oral presentation(invited, special)	Disclose to all
ポリフェノールによるアミロイドβの凝集阻害機構[Invited]	ポリフェノールによるアミロイドβの凝集阻害機構 [Invited]		第31回日本認知症学会学術集会	第31回日本認知症学会学術集会		日本認知症学会	日本認知症学会		2012/10/28	Japanese	Oral presentation(invited, special)	Disclose to all
プロテインキナーゼＣを標的とした新規抗がん剤シーズ[Invited]	プロテインキナーゼＣを標的とした新規抗がん剤シーズ [Invited]		京都大学新技術説明会	京都大学新技術説明会		京都大学・科学技術振興機構	京都大学・科学技術振興機構		2012/08/24	Japanese	Oral presentation(invited, special)	Disclose to all
天然発がんプロモーターの骨格を利用した新規抗がん剤リードの開発[Invited]	天然発がんプロモーターの骨格を利用した新規抗がん剤リードの開発 [Invited]		2012年度大会シンポジウム	2012年度大会シンポジウム		日本農芸化学会	日本農芸化学会		2012/03/25	Japanese	Oral presentation(invited, special)	Disclose to all
抗がん剤開発を指向した新規PKCリガンドの創製と作用機構解析[Invited]	抗がん剤開発を指向した新規PKCリガンドの創製と作用機構解析 [Invited]		新学術領域研究「天然物ケミカルバイオロジー」第一回公開シンポジウム	新学術領域研究「天然物ケミカルバイオロジー」第一回公開シンポジウム		新学術領域研究「天然物ケミカルバイオロジー」総括班	新学術領域研究「天然物ケミカルバイオロジー」総括班		2012/01/10	Japanese	Oral presentation(invited, special)	Disclose to all
発がんプロモーターの骨格を利用した新規ツール分子と抗がん剤シーズの開発[Invited]	発がんプロモーターの骨格を利用した新規ツール分子と抗がん剤シーズの開発 [Invited]		日本農芸化学会関西支部例会（第472回講演会）	日本農芸化学会関西支部例会（第472回講演会）		日本農芸化学会関西支部	日本農芸化学会関西支部		2011/12/10	Japanese	Oral presentation(invited, special)	Disclose to all
Development of new molecular probes and therapeutic seeds having skeletons of naturally-occurring tumor promoters[Invited]	Development of new molecular probes and therapeutic seeds having skeletons of naturally-occurring tumor promoters [Invited]	Development of new molecular probes and therapeutic seeds having skeletons of naturally-occurring tumor promoters [Invited]	22nd French-Japanese Symposium of Medicinal and Fine Chemistry (Rouen, France)	22nd French-Japanese Symposium of Medicinal and Fine Chemistry (Rouen, France)	22nd French-Japanese Symposium of Medicinal and Fine Chemistry (Rouen, France)				2011/09/13	English	Oral presentation(invited, special)	Disclose to all
Synthesis and structure-activity studies of the simplified analogue of aplysiatoxin with antiproliferative activity like bryostatin 1[Invited]	Synthesis and structure-activity studies of the simplified analogue of aplysiatoxin with antiproliferative activity like bryostatin 1 [Invited]	Synthesis and structure-activity studies of the simplified analogue of aplysiatoxin with antiproliferative activity like bryostatin 1 [Invited]	27th International Symposium on the Chemistry of Natural Products, 7th International Conference on Biodiversity (Brisbane, Australia)	27th International Symposium on the Chemistry of Natural Products, 7th International Conference on Biodiversity (Brisbane, Australia)	27th International Symposium on the Chemistry of Natural Products, 7th International Conference on Biodiversity (Brisbane, Australia)				2011/07/11	English	Oral presentation(invited, special)	Disclose to all
アミロイドβの毒性ターン構造を認識する抗体の開発[Invited]	アミロイドβの毒性ターン構造を認識する抗体の開発 [Invited]		第52回日本神経学会学術大会（名古屋）	第52回日本神経学会学術大会（名古屋）		日本神経学会	日本神経学会		2011/05/19	Japanese	Oral presentation(invited, special)	Disclose to all
アミロイドβタンパクの毒性コンホメーションの同定と薬剤開発[Invited]	アミロイドβタンパクの毒性コンホメーションの同定と薬剤開発 [Invited]		香川大学農学部第２回公開シンポジウム「生命を化学の視点から探究する」	香川大学農学部第２回公開シンポジウム「生命を化学の視点から探究する」					2010	Japanese	Public discourse, seminar, tutorial, course, lecture and others	Disclose to all
Development of anticancer compounds using the skeleton of tumor promoter aplysiatoxin[Invited]	Development of anticancer compounds using the skeleton of tumor promoter aplysiatoxin [Invited]	Development of anticancer compounds using the skeleton of tumor promoter aplysiatoxin [Invited]	The 25th Naito Conference, Chemical Biology [II] -An Emerging Field Inspired by Natural Product Chemistry- (Sapporo, Japan)	The 25th Naito Conference, Chemical Biology [II] -An Emerging Field Inspired by Natural Product Chemistry- (Sapporo, Japan)	The 25th Naito Conference, Chemical Biology [II] -An Emerging Field Inspired by Natural Product Chemistry- (Sapporo, Japan)				2009	English	Oral presentation(invited, special)	Disclose to all
βアミロイドの立体構造解析と神経細胞毒性発現機構[Invited]	βアミロイドの立体構造解析と神経細胞毒性発現機構 [Invited]		第43回天然物化学談話会（大阪）	第43回天然物化学談話会（大阪）					2008	Japanese	Oral presentation(invited, special)	Disclose to all
アミロイドβ凝集体の立体構造解析と神経細胞毒性発現機構[Invited]	アミロイドβ凝集体の立体構造解析と神経細胞毒性発現機構 [Invited]		彩都バイオヒルズクラブ　プロテオミクスシンポジウム（大阪）	彩都バイオヒルズクラブ　プロテオミクスシンポジウム（大阪）					2008	Japanese	Oral presentation(invited, special)	Disclose to all
抗がん剤の開発に向けたブライオスタチン等価体の開発[Invited]	抗がん剤の開発に向けたブライオスタチン等価体の開発 [Invited]		毒素研究会シンポジウム（東京）	毒素研究会シンポジウム（東京）					2008	Japanese	Oral presentation(invited, special)	Disclose to all
固体NMR及びESRによるβアミロイドの立体構造と神経細胞毒性発現機構の解析[Invited]	固体NMR及びESRによるβアミロイドの立体構造と神経細胞毒性発現機構の解析 [Invited]		理研シンポジウム：「第9回　分析・解析技術と化学の最先端」（東京）	理研シンポジウム：「第9回　分析・解析技術と化学の最先端」（東京）					2008	Japanese	Oral presentation(invited, special)	Disclose to all
アミロイドβタンパクの毒性コンホメーション[Invited]	アミロイドβタンパクの毒性コンホメーション [Invited]		第54回白鷺セミナー（大阪）	第54回白鷺セミナー（大阪）					2008	Japanese	Oral presentation(invited, special)	Disclose to all
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Books etc

Author	Author(Japanese)	Author(English)	Title	Title(Japanese)	Title(English)	Publisher	Publisher(Japanese)	Publisher(English)	Publication date	Language	Type	Disclose
入江一浩*, 村上一馬（分担執筆，p52-59）	入江一浩*, 村上一馬（分担執筆，p52-59）	入江一浩*, 村上一馬（分担執筆，p52-59）	認知症, 実験医学増刊, Vol.35-No.12, 2017	認知症, 実験医学増刊, Vol.35-No.12, 2017	認知症, 実験医学増刊, Vol.35-No.12, 2017	Yodosha	羊土社	Yodosha	2017/07	Japanese	Contributor	Disclose to all
入江一浩（分担執筆, p75-91）	入江一浩（分担執筆, p75-91）	入江一浩（分担執筆, p75-91）	有機化学要論	有機化学要論	有機化学要論	学術図書出版社，入江一浩, 津江広人編著	学術図書出版社，入江一浩, 津江広人編著	学術図書出版社，入江一浩, 津江広人編著	2015/04	Japanese	Contributor	Disclose to all
K. Murakami*, K. Irie and T. Shimizu	K. Murakami*, K. Irie and T. Shimizu	K. Murakami*, K. Irie and T. Shimizu	Potential role of vitamin C in the prevention of Alzheimer’s disease	Potential role of vitamin C in the prevention of Alzheimer’s disease	Potential role of vitamin C in the prevention of Alzheimer’s disease	Elsevier, C. R. Martin and V. R. Prredy (Eds.), Diet and Nutrition in Dementia and Cognitive Decline, p.663-668	Elsevier, C. R. Martin and V. R. Prredy (Eds.), Diet and Nutrition in Dementia and Cognitive Decline, p.663-668	Elsevier, C. R. Martin and V. R. Prredy (Eds.), Diet and Nutrition in Dementia and Cognitive Decline, p.663-668	2015	English	Joint Work	Disclose to all
入江一浩	入江一浩		アプリシアトキシンの骨格を利用した抗がん剤シーズの開発研究	アプリシアトキシンの骨格を利用した抗がん剤シーズの開発研究		日本化学会編，CSJ Current Review 19, 生物活性分子のケミカルバイオロジー, Chapter 12, p127-133	日本化学会編，CSJ Current Review 19, 生物活性分子のケミカルバイオロジー, Chapter 12, p127-133		2015	Japanese	Joint Work	Disclose to all
村上一馬, 増田裕一, 入江一浩*	村上一馬, 増田裕一, 入江一浩*		固体NMRおよびESRによるアミロイドβの立体構造解析と毒性ターン構造特異抗体の開発	固体NMRおよびESRによるアミロイドβの立体構造解析と毒性ターン構造特異抗体の開発		メディカル　ドゥ，遺伝子医学MOOK 21号，最新ペプチド合成技術とその創薬研究への応用，p211-216	メディカル　ドゥ，遺伝子医学MOOK 21号，最新ペプチド合成技術とその創薬研究への応用，p211-216		2012	Japanese	Joint Work	Disclose to all
Y. Masuda, S. Uemura, R. Ohashi, A. Nakanishi, K. Takegoshi and K. Irie*	Y. Masuda, S. Uemura, R. Ohashi, A. Nakanishi, K. Takegoshi and K. Irie*	Y. Masuda, S. Uemura, R. Ohashi, A. Nakanishi, K. Takegoshi and K. Irie*	Identification of toxic conformation in Aβ42 aggregates using solid-state NMR	Identification of toxic conformation in Aβ42 aggregates using solid-state NMR	Identification of toxic conformation in Aβ42 aggregates using solid-state NMR	Peptide Science 2008, p25-28	Peptide Science 2008, p25-28	Peptide Science 2008, p25-28	2009	English	Single Work	Disclose to all
K. Murakami, K. Irie*, H. Ohigashi, H. Hara, M. Nagao, T. Shimizu and T. Shirasawa	K. Murakami, K. Irie*, H. Ohigashi, H. Hara, M. Nagao, T. Shimizu and T. Shirasawa	K. Murakami, K. Irie*, H. Ohigashi, H. Hara, M. Nagao, T. Shimizu and T. Shirasawa	'Malignant' conformation of Alzheimer's beta peptide (Abeta42) through radical formation	'Malignant' conformation of Alzheimer's beta peptide (Abeta42) through radical formation	'Malignant' conformation of Alzheimer's beta peptide (Abeta42) through radical formation	Peptide Science 2006, p19-20	Peptide Science 2006, p19-20	Peptide Science 2006, p19-20	2006	English	Single Work	Disclose to all
K. Murakami, K. Irie*, A. Morimoto, Y. Masuda, H. Ohigashi, M. Nagao, H. Fukuda, T. Shimizu and T. Shirasawa	K. Murakami, K. Irie*, A. Morimoto, Y. Masuda, H. Ohigashi, M. Nagao, H. Fukuda, T. Shimizu and T. Shirasawa	K. Murakami, K. Irie*, A. Morimoto, Y. Masuda, H. Ohigashi, M. Nagao, H. Fukuda, T. Shimizu and T. Shirasawa	New aggregation model of amyloid β by the systematic proline replacement	New aggregation model of amyloid β by the systematic proline replacement	New aggregation model of amyloid β by the systematic proline replacement	Peptide Science 2004, p179-182	Peptide Science 2004, p179-182	Peptide Science 2004, p179-182	2005	English	Single Work	Disclose to all
M. Shindo*, K. Irie, H. Ohigashi, M. Kuriyama and N. Saito	M. Shindo*, K. Irie, H. Ohigashi, M. Kuriyama and N. Saito	M. Shindo*, K. Irie, H. Ohigashi, M. Kuriyama and N. Saito	Tumor-promoting phorbol esters bind directly to the regulatory domain of diacylglycerol kinase gamma	Tumor-promoting phorbol esters bind directly to the regulatory domain of diacylglycerol kinase gamma	Tumor-promoting phorbol esters bind directly to the regulatory domain of diacylglycerol kinase gamma	Peptide Science 2001, p207-210	Peptide Science 2001, p207-210	Peptide Science 2001, p207-210	2002	English	Single Work	Disclose to all
K. Irie*, A. Nakahara, Y. Nakagawa, H. Ohigashi, M. Shindo, H. Fukuda, H. Konishi and U. Kikkawa	K. Irie*, A. Nakahara, Y. Nakagawa, H. Ohigashi, M. Shindo, H. Fukuda, H. Konishi and U. Kikkawa	K. Irie*, A. Nakahara, Y. Nakagawa, H. Ohigashi, M. Shindo, H. Fukuda, H. Konishi and U. Kikkawa	Selective binding of tumor promoters to the novel PKC C1B domains	Selective binding of tumor promoters to the novel PKC C1B domains	Selective binding of tumor promoters to the novel PKC C1B domains	Peptide Science 2000, p197-200	Peptide Science 2000, p197-200	Peptide Science 2000, p197-200	2001	English	Single Work	Disclose to all
K. Irie*, K. Oie, A. Nakahara, Y. Yanai, H. Ohigashi, H. Fukuda and P. A. Wender	K. Irie*, K. Oie, A. Nakahara, Y. Yanai, H. Ohigashi, H. Fukuda and P. A. Wender	K. Irie*, K. Oie, A. Nakahara, Y. Yanai, H. Ohigashi, H. Fukuda and P. A. Wender	Synthesis and phorbol ester binding of the zinc-finger like sequences of all protein kinase C isozymes	Synthesis and phorbol ester binding of the zinc-finger like sequences of all protein kinase C isozymes	Synthesis and phorbol ester binding of the zinc-finger like sequences of all protein kinase C isozymes	Peptide Science 1998, p65-68	Peptide Science 1998, p65-68	Peptide Science 1998, p65-68	1999	English	Single Work	Disclose to all
K. Irie*, Y. Yanai, H. Ohigashi and P. A. Wender	K. Irie*, Y. Yanai, H. Ohigashi and P. A. Wender	K. Irie*, Y. Yanai, H. Ohigashi and P. A. Wender	Synthesis and characterization of model peptides incorporating the phorbol ester-binding domain of protein kinase C	Synthesis and characterization of model peptides incorporating the phorbol ester-binding domain of protein kinase C	Synthesis and characterization of model peptides incorporating the phorbol ester-binding domain of protein kinase C	Peptide Chemistry 1996, 209-212	Peptide Chemistry 1996, 209-212	Peptide Chemistry 1996, 209-212	1997	English	Single Work	Disclose to all
K. Irie* and K. Koshimizu	K. Irie* and K. Koshimizu	K. Irie* and K. Koshimizu	The indole alkaloid tumor promoter teleocidins as Epstein-Barr virus inducers: structure, biosynthesis and structure-activity relationship	The indole alkaloid tumor promoter teleocidins as Epstein-Barr virus inducers: structure, biosynthesis and structure-activity relationship	The indole alkaloid tumor promoter teleocidins as Epstein-Barr virus inducers: structure, biosynthesis and structure-activity relationship	Natural Products as Antiviral Agents (Plenum), 257-273	Natural Products as Antiviral Agents (Plenum), 257-273	Natural Products as Antiviral Agents (Plenum), 257-273	1992	English	Single Work	Disclose to all
T. Ando, K. Irie, K. Koshimizu*, S. Nakajima, T. Takemura and I. Sakata	T. Ando, K. Irie, K. Koshimizu*, S. Nakajima, T. Takemura and I. Sakata	T. Ando, K. Irie, K. Koshimizu*, S. Nakajima, T. Takemura and I. Sakata	A convenient synthesis of chlorin e6 dimer and trimer	A convenient synthesis of chlorin e6 dimer and trimer	A convenient synthesis of chlorin e6 dimer and trimer	Photodynamic Therapy and Biomedical Lasers (Elsevier Science Publishers B.V.), 764-768	Photodynamic Therapy and Biomedical Lasers (Elsevier Science Publishers B.V.), 764-768	Photodynamic Therapy and Biomedical Lasers (Elsevier Science Publishers B.V.), 764-768	1992	English	Single Work	Disclose to all
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Patents

Inventor(s)	Inventor(s) (Japanese)	Title	Title(Japanese)	Stage	Patent number	Date	Disclose
入江一浩，菊森将之，蒲池弘明，柳田　亮，中川　優	入江一浩，菊森将之，蒲池弘明，柳田　亮，中川　優	新規アプリシアトキシン誘導体及びそれを含有する抗がん剤	新規アプリシアトキシン誘導体及びそれを含有する抗がん剤	特許登録	特許第６１７０９０８号	2017/07/07	Disclose to all
Irie, K., Murakami, K., Masuda, Y., Shimizu, T., Shirasawa, T., Seito, T.	Irie, K., Murakami, K., Masuda, Y., Shimizu, T., Shirasawa, T., Seito, T.	Antibody recognizing turn structure in amyloid β	Antibody recognizing turn structure in amyloid β	特許登録	特許US 8,710,193; CN ZL201080046483.9	2014/04/29	Disclose to all
入江一浩，村上一馬，清水孝彦，泉尾直孝，清藤　勉	入江一浩，村上一馬，清水孝彦，泉尾直孝，清藤　勉	アミロイドβの22位及び23位のターン構造を極めて特異的に認識する抗体	アミロイドβの22位及び23位のターン構造を極めて特異的に認識する抗体	特許出願	特願２０１４−２５１８９８，２０１５−１０４４１１	2015/05/22	Disclose to all
入江一浩，村上一馬，増田裕一，清水孝彦，白澤卓二，清藤勉	入江一浩，村上一馬，増田裕一，清水孝彦，白澤卓二，清藤勉	アミロイドβのターン構造を認識する抗体	アミロイドβのターン構造を認識する抗体	特許出願	特願２００９−２３９５４２	2009/10/16	Disclose to all
Title language:

Awards

Title(Japanese)	Title(English)	Organization name(Japanese)	Organization name(English)	Date
井上研究奨励賞	Inoue Research Aid for Young Scientists	井上科学振興財団	Inoue Foundation for Science	1990
農芸化学奨励賞	Japan Society for Bioscience, Biotechnology and Agrochemistry Award for the Encouragement of Young Scientists	日本農芸化学会	Japan Society for Bioscience, Biotechnology and Agrochemistry	1994
2008年度BBB論文賞	Award for Excellence to Authors Publishing in Bioscience, Biotechnology, and Biochemistry in 2008	日本農芸化学会	Japan Society for Bioscience, Biotechnology and Agrochemistry	2009

Newspaper articles

Title	Media name	Column name	Date
アルツハイマー病原因検出に新手法	京都新聞	朝刊29面	2016/07/05
新たな抗体で「早期診断」	毎日新聞	朝刊27面	2016/07/13
抗体開発　アルツハイマー病の早期診断に期待	朝日放送	「おはよう朝日です」など	2016/07/05

External funds, competitive funds and Grants-in-Aid for Scientific Research(kaken)

Type	Position	Title(Japanese)	Title(English)	Period
新学術領域研究（計画）	Representative	天然PKCリガンドによる化学コミュニケーションの統合的理解と医薬品シーズの開発	Unified comprehension of chemical communication by natural PKC ligands and development of new medicinal seeds	2017/06/30-2022/03/31
基盤研究（Ｓ）	Representative	アミロイドβの毒性配座理論を基盤としたアルツハイマー病の新しい予防戦略	New prevention strategy for Alzheimer's disease based on the toxic conformation of amyloid β	2014/05/30-2019/03/31
基盤研究（Ａ）	Representative	アミロイドβの毒性配座理論に基づいたアルツハイマー病の新規診断法の開発	Development of new diagnostic method for Alzheimer's disease based on the toxic conformation of amyloid β	2014/04/01-2014/05/30
新学術領域研究（計画）	Representative	抗がん剤開発を指向した新規ＰＫＣリガンドの創製と作用機構解析	Development and mechanistic analysis of new PKC ligands as anti-cancer agents	2011-2015
挑戦的萌芽研究	Representative	難治性疾患に対する分子標的薬シードとしての新規ＰＫＣリガンドの探索研究	Screening of new PKC ligands as seeds for intractable diseases	2011-2012
基盤研究（Ａ）	Representative	アミロイドβの毒性オリゴマーの構造解析に基づいた抗アルツハイマー病薬の開発	Development of agents against Alzheimer's disease based on the structural analysis of amyloid beta oligomers	2009-2013
萌芽研究	Representative	インドール環４位への窒素原子導入酵素の触媒機構の解析と応用	Analysis of the reaction mechanism of the enzyme that catalyzes the introduction of a nitrogen atom on the 4 position of indole	2008-2009
基盤研究（Ａ）	Representative	βアミロイドの新しい凝集モデルに基づいた抗体および凝集阻害剤の開発	Development of antibodies and aggregation inhibitors for amyloid β peptides based on the new aggregation model	2006-2008
特定領域研究（公募）	Representative	CH/π相互作用を利用したＰＫＣアイソザイム選択的な薬剤開発	Molecular design of agents with selectivity for protein kinase C isozymes based on the CH/π interaction	2006-2007

Non-external, competitive funds or grants other than grants-in-aid for Scientific research (kaken)

System	Main person	Title(Japanese)	Period
上原記念生命科学財団 2016年度研究助成	入江一浩	天然ＰＫＣリガンドの医薬品シーズとしての構造最適化	2017/02/08-2018/04/30
武田科学振興財団 2013年度生命科学研究助成	入江一浩	Aβオリゴマーの毒性配座理論を基盤としたアルツハイマー病の治療戦略	2013/10/1-2016/05/31
アサヒグループ学術振興財団 2010年度研究助成	入江一浩	食品中のポリフェノール類によるアミロイドβの毒性緩和機構	2008/02/07-2012/03/31
上原記念生命科学財団 2007年度研究助成	入江一浩	ブライオスタチンのプロテイキナーゼＣ活性化機構に基づいた新規抗がん剤の設計	2008/04/01-2009/04/30
内藤記念科学振興財団 2006年度研究助成	入江一浩	プロテインキナーゼＣアイソザイムを標的とした新しい抗がん剤の設計	2007/04/01-2008/03/31
松籟科学技術振興財団 2006年度研究助成	入江一浩	Daphnoretinをリードとした抗がん剤の開発	2007/04/01-2008/03/31

Teaching subject(s)

Name(Japanese)	Name(English)	Term	Department	Period
農学部：食品有機化学 I、II、III、生命有機化学、有機化学実験及び実験法、食品生物科学入門及び実習	Faculty of Agriculture: Organic Chemistry in Food Science I, II, III, Organic Chemistry in Life Science, Laboratory Course in Organic Chemistry, Introduction and Practice in the Department of Food Science and Biotechnology			-
農学研究科：生体反応有機化学、食品生命科学特論、生命有機化学専攻演習、生命有機化学専攻実験	Graduate School of Agriculture: Organic Chemistry in Life Science, Food and Life Science (Advanced Course), Seminar of Organic Chemistry in Life Science, Experimental Course of Organic Chemistry in Life Science			-
食品有機化学I		後期	農学部	2011/04-2012/03
食品有機化学II		前期	農学部	2011/04-2012/03
食品有機化学III		後期	農学部	2011/04-2012/03
生命有機化学		前期	農学部	2011/04-2012/03
有機化学実験及び実験法		前期	農学部	2011/04-2012/03
生命有機化学	Organic Chemistry in Life Science	前期	農学部	2012/04-2013/03
食品有機化学III	Organic Chemistry in Food Science III	後期	農学部	2012/04-2013/03
食品有機化学II	Organic Chemistry in Food Science II	前期	農学部	2012/04-2013/03
食品有機化学Ｉ	Organic Chemistry in Food Science I	後期	農学部	2012/04-2013/03
食品有機化学実験及び実験法	Laboratory Course in Organic Chemistry in Food Science	前期	農学部	2012/04-2013/03
食品生物科学演習	Seminar on Food Science and Biotechnology	前期	農学部	2012/04-2013/03
食品有機化学Ｉ	Organic Chemistry in Food Science I	後期	農学部	2013/04-2014/03
食品有機化学II	Organic Chemistry in Food Science II	前期	農学部	2013/04-2014/03
食品有機化学III	Organic Chemistry in Food Science III	後期	農学部	2013/04-2014/03
生命有機化学	Organic Chemistry in Life Science	前期	農学部	2013/04-2014/03
食品有機化学実験及び実験法	Laboratory Course in Organic Chemistry in Food Science	前期	農学部	2013/04-2014/03
生命有機化学専攻演習	Seminar of Organic Chemistry in Life Science	通年	農学研究科	2013/04-2014/03
生命有機化学専攻実験	Experimental Course of Organic Chemistry in Life Science	通年	農学研究科	2013/04-2014/03
食品有機化学Ｉ	Organic Chemistry in Food Science I	後期	農学部	2014/04-2015/03
食品有機化学II	Organic Chemistry in Food Science II	前期	農学部	2014/04-2015/03
食品有機化学III	Organic Chemistry in Food Science III	後期	農学部	2014/04-2015/03
生命有機化学	Organic Chemistry in Life Science	前期	農学部	2014/04-2015/03
食品有機化学実験及び実験法	Laboratory Course in Organic Chemistry in Food Science	前期	農学部	2014/04-2015/03
生体反応有機化学	Organic Chemistry in Life Science	前期集中	農学研究科	2014/04-2015/03
生命有機化学専攻演習	Seminar of Organic Chemistry in Life Science	通年	農学研究科	2014/04-2015/03
生命有機化学専攻実験	Experimental Course of Organic Chemistry in Life Science	通年	農学研究科	2014/04-2015/03
生理化学概論	Outline of Physiological Chemistry	後期	農学研究科	2014/04-2015/03
生命有機化学	Organic Chemistry in Life Science	前期	農学部	2015/04-2016/03
生命有機化学専攻実験１	Experimental Course of Organic Chemistry in Life Science1	通年	農学研究科	2015/04-2016/03
生命有機化学専攻実験	Experimental Course of Organic Chemistry in Life Science	通年	農学研究科	2015/04-2016/03
生命有機化学専攻演習１	Seminar of Organic Chemistry in Life Science1	通年	農学研究科	2015/04-2016/03
生命有機化学専攻演習	Seminar of Organic Chemistry in Life Science	通年	農学研究科	2015/04-2016/03
生理化学概論	Outline of Physiological Chemistry	後期	農学研究科	2015/04-2016/03
食品有機化学III	Organic Chemistry in Food Science III	後期	農学部	2015/04-2016/03
食品有機化学II	Organic Chemistry in Food Science II	前期	農学部	2015/04-2016/03
食品有機化学Ｉ	Organic Chemistry in Food Science I	後期	農学部	2015/04-2016/03
食品有機化学実験及び実験法	Laboratory Course in Organic Chemistry in Food Science	前期	農学部	2015/04-2016/03
天然物化学	Natural Products Chemistry	前期	農学部	2016/04-2017/03
生体反応有機化学	Organic Chemistry in Life Science	前期集中	農学研究科	2016/04-2017/03
生命有機化学専攻実験１	Experimental Course of Organic Chemistry in Life Science1	通年	農学研究科	2016/04-2017/03
生命有機化学専攻実験２	Experimental Course of Organic Chemistry in Life Science2	通年	農学研究科	2016/04-2017/03
生命有機化学専攻実験	Experimental Course of Organic Chemistry in Life Science	通年	農学研究科	2016/04-2017/03
生命有機化学専攻演習１	Seminar of Organic Chemistry in Life Science1	通年	農学研究科	2016/04-2017/03
生命有機化学専攻演習２	Seminar of Organic Chemistry in Life Science2	通年	農学研究科	2016/04-2017/03
生命有機化学専攻演習	Seminar of Organic Chemistry in Life Science	通年	農学研究科	2016/04-2017/03
食品工業論	Food Science and Production Technology	前期	農学部	2016/04-2017/03
食品有機化学III	Organic Chemistry in Food Science III	後期	農学部	2016/04-2017/03
食品有機化学II	Organic Chemistry in Food Science II	前期	農学部	2016/04-2017/03
食品有機化学Ｉ	Organic Chemistry in Food Science I	後期	農学部	2016/04-2017/03
食品有機化学実験及び実験法	Laboratory Course in Organic Chemistry in Food Science	前期	農学部	2016/04-2017/03
天然物化学	Natural Products Chemistry	前期	農学部	2017/04-2018/03
生命有機化学専攻実験１	Experimental Course of Organic Chemistry in Life Science1	通年	農学研究科	2017/04-2018/03
生命有機化学専攻実験２	Experimental Course of Organic Chemistry in Life Science2	通年	農学研究科	2017/04-2018/03
生命有機化学専攻演習１	Seminar of Organic Chemistry in Life Science1	通年	農学研究科	2017/04-2018/03
生命有機化学専攻演習２	Seminar of Organic Chemistry in Life Science2	通年	農学研究科	2017/04-2018/03
生物有機化学特論	Advanced Course of Bioorganic Chemistry	前期集中	農学研究科	2017/04-2018/03
食品有機化学III	Organic Chemistry in Food Science III	後期	農学部	2017/04-2018/03
食品有機化学II	Organic Chemistry in Food Science II	前期	農学部	2017/04-2018/03
食品有機化学I	Organic Chemistry in Food Science I	後期	農学部	2017/04-2018/03
食品有機化学実験及び実験法	Laboratory Course in Organic Chemistry in Food Science	前期	農学部	2017/04-2018/03
天然物化学	Natural Products Chemistry	前期	農学部	2018/04-2019/03
天然物化学特論	Advanced Course of Natural Products Chemistry	前期集中	農学研究科	2018/04-2019/03
生命有機化学専攻実験１	Experimental Course of Organic Chemistry in Life Science1	通年	農学研究科	2018/04-2019/03
生命有機化学専攻実験２	Experimental Course of Organic Chemistry in Life Science2	通年	農学研究科	2018/04-2019/03
生命有機化学専攻演習１	Seminar of Organic Chemistry in Life Science1	通年	農学研究科	2018/04-2019/03
生命有機化学専攻演習２	Seminar of Organic Chemistry in Life Science2	通年	農学研究科	2018/04-2019/03
生理化学概論	Outline of Physiological Chemistry	後期集中	全学共通科目	2018/04-2019/03
食品有機化学III	Organic Chemistry in Food Science III	後期	農学部	2018/04-2019/03
食品有機化学II	Organic Chemistry in Food Science II	前期	農学部	2018/04-2019/03
食品有機化学I	Organic Chemistry in Food Science I	後期	農学部	2018/04-2019/03
食品有機化学実験及び実験法	Laboratory Course in Organic Chemistry in Food Science	前期	農学部	2018/04-2019/03
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Part-time lecturer (outside KU)

Cource name(Japanese)	Term	University	Department	Period
生命有機化学	平成25年度前期集中	広島大学	大学院理学研究科	2013/04/09-2013/09/30
天然物有機化学	平成26年度前期集中	広島大学	理学部	2014/04/09-2014/09/30
天然物有機化学	平成27年度前期集中	広島大学	大学院理学研究科	2015/04/08-2015/09/30
ケミカルバイオロジー特論	平成27年度後期	東京大学	大学院薬学系研究科	2015/09/01-2016/03/31
天然物有機化学	2016年前期集中	広島大学	大学院理学研究科	2016/04/01-2016/09/30
天然物有機化学Ⅰ	2017年前期集中	広島大学	大学院理学研究科	2017/04/01-2017/09/30

School management (title, position)

Title	Period
放射線取扱主任者（農学研究科）、京都大学全学共通科目化学部会委員、低温物質科学研究センター協議員会協議員	-
総長室特命補佐	2008/10/01-2010/09/30
設備整備ワーキンググループ委員	2011/04/01-2013/03/31
吉田キャンパスマスタープラン専門部会部会員	2012/10/01-2016/09/30
国際高等教育院企画評価専門委員会化学部会委員	2014/06/01-2019/03/31
学際融合教育研究推進センター運営委員会委員	2011/04/01-2013/03/31
高等教育研究開発推進機構基礎教育専門委員会・化学部会委員	2005/04/01-2013/03/31
低温物質科学研究センター協議員会委員	2010/04/01-2012/03/31
低温物質科学研究センター協議員会委員	2012/04/01-2014/03/31
低温物質科学研究センター協議員会委員	2014/04/01-2016/03/31
放射性同位元素等専門委員会委員	2013/04/01-2017/03/31
学際融合教育研究推進センター生理化学研究ユニット長	2011/04/01-2016/03/31
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Faculty management (title, position)

Title	Period
ＦＤ委員会　委員	2014/04/01-2016/03/31
学部教務委員会　委員	2013/04/01-2016/03/31
建築委員会　委員	2015/04/01-2019/03/31
放射線障害防止委員会　委員	2013/04/01-2017/03/31
食品生物科　学科長	2016/04/01-2018/03/31
評価委員会　委員	2016/04/01-2018/03/31
将来構想検討委員会　委員	2017/04/01-2019/03/31
評価委員会　委員	2018/04/01-2019/03/31
防火・防災委員会　委員	2018/04/01-2019/03/31
食品生物科学専攻長	2018/04/01-2019/03/31

Academic organizations (administrative title, position)

Organization name(Japanese)	Organization name(English)	Title(Japanese)	Title(English)	Period
新規素材探索研究会		幹事		2008-
天然有機化合物討論会世話人会メンバー		世話人		2008-
日本農芸化学会	Japan Society for Bioscience, Biotechnology, and Agrochemistry	評議員	Councilor	2010/04/01-2012/03/31
日本認知症学会	Japan Society for Dementia Research	代議員	Councilor	2010/04/01-2019/03/31
京都生体質量分析研究会	Kyoto Biomolecular Mass Spectrometry Society	世話人	Organizer	2016/09/28-

Other activities (awards)

Award name	Organization name	Date
平成28年度科研費　審査委員表彰	日本学術振興会	2016/09/30

History of staying abroad

Organization	Department	Research theme	Country	Period
スタンフォード大学	化学科	光親和性標識によるプロテインキナーゼＣと発がんプロモーターとの結合様式の解析	米国	1992/04/08-1993/03/25

入江 一浩

入江一浩