K. Irie* |
K. Irie* |
K. Irie* |
New diagnostic method for Alzheimer's disease based on the toxic conformation theory of amyloid β |
New diagnostic method for Alzheimer's disease based on the toxic conformation theory of amyloid β |
New diagnostic method for Alzheimer's disease based on the toxic conformation theory of amyloid β |
Biosci. Biotechnol. Biochem., 84, 1, 1-16 |
Biosci. Biotechnol. Biochem., 84, 1, 1-16 |
Biosci. Biotechnol. Biochem., 84, 1, 1-16 |
2020 |
Refereed |
English |
Research paper(scientific journal) |
Disclose to all |
K. Nishino, H. Uesugi, A. Hirasawa, A. Ohtera, Y. Miyamae, M. Neffati, H. Isoda, T. Kambe, S. Masuda, K. Irie and M. Nagao* |
K. Nishino, H. Uesugi, A. Hirasawa, A. Ohtera, Y. Miyamae, M. Neffati, H. Isoda, T. Kambe, S. Masuda, K. Irie and M. Nagao* |
K. Nishino, H. Uesugi, A. Hirasawa, A. Ohtera, Y. Miyamae, M. Neffati, H. Isoda, T. Kambe, S. Masuda, K. Irie and M. Nagao* |
Stimulation of insulin secretion by acetylenic fatty acids in insulinoma MIN6 cells through FFAR1 |
Stimulation of insulin secretion by acetylenic fatty acids in insulinoma MIN6 cells through FFAR1 |
Stimulation of insulin secretion by acetylenic fatty acids in insulinoma MIN6 cells through FFAR1 |
Biochem. Biophys. Res. Commun., in press |
Biochem. Biophys. Res. Commun., in press |
Biochem. Biophys. Res. Commun., in press |
2019 |
Refereed |
English |
Research paper(scientific journal) |
Disclose to all |
Y. Ashida, R. C. Yanagita*, Y. Kawanami, M. Okamura, S. Dan and K. Irie |
Y. Ashida, R. C. Yanagita*, Y. Kawanami, M. Okamura, S. Dan and K. Irie |
Y. Ashida, R. C. Yanagita*, Y. Kawanami, M. Okamura, S. Dan and K. Irie |
Synthesis, conformation, and biological activities of a des-A-ring analog of 18-deoxy-aplog-1, a simplified analog of debromoaplysiatoxin |
Synthesis, conformation, and biological activities of a des-A-ring analog of 18-deoxy-aplog-1, a simplified analog of debromoaplysiatoxin |
Synthesis, conformation, and biological activities of a des-A-ring analog of 18-deoxy-aplog-1, a simplified analog of debromoaplysiatoxin |
Heterocycles, 99, 2, 942-957 |
Heterocycles, 99, 2, 942-957 |
Heterocycles, 99, 2, 942-957 |
2019 |
Refereed |
English |
Research paper(scientific journal) |
Disclose to all |
IRIE Kazuhiro |
入江一浩* |
IRIE Kazuhiro |
アミロイドβの毒性2量体および3量体モデルの合成と構造機能解析 |
アミロイドβの毒性2量体および3量体モデルの合成と構造機能解析 |
アミロイドβの毒性2量体および3量体モデルの合成と構造機能解析 |
有機合成化学協会誌, 77, 12, 1201-1208 |
有機合成化学協会誌, 77, 12, 1201-1208 |
有機合成化学協会誌, 77, 12, 1201-1208 |
2019 |
Refereed |
Japanese |
Research paper(scientific journal) |
Disclose to all |
N. Izuo, K. Murakami, Y. Fujihara, M. Maeda, T. Saito, T. C. Saido, K. Irie and T. Shimizu* |
N. Izuo, K. Murakami, Y. Fujihara, M. Maeda, T. Saito, T. C. Saido, K. Irie and T. Shimizu* |
N. Izuo, K. Murakami, Y. Fujihara, M. Maeda, T. Saito, T. C. Saido, K. Irie and T. Shimizu* |
An App knock-in mouse inducing the formation of a toxic conformer of Aβ as a model for evaluating only oligomer-induced cognitive decline in Alzheimer's disease |
An App knock-in mouse inducing the formation of a toxic conformer of Aβ as a model for evaluating only oligomer-induced cognitive decline in Alzheimer's disease |
An App knock-in mouse inducing the formation of a toxic conformer of Aβ as a model for evaluating only oligomer-induced cognitive decline in Alzheimer's disease |
Biochem. Biophys. Res. Commun., 515, 3, 462-467 |
Biochem. Biophys. Res. Commun., 515, 3, 462-467 |
Biochem. Biophys. Res. Commun., 515, 3, 462-467 |
2019 |
Refereed |
English |
Research paper(scientific journal) |
Disclose to all |
Y. Irie, M. Hanaki, K. Murakami, T. Imamoto, T. Furuta, T. Kawabata, T. Kawase, K. Hirose, Y. Monobe, K.-i. Akagi, R. C. Yanagita and K. Irie* |
Y. Irie, M. Hanaki, K. Murakami, T. Imamoto, T. Furuta, T. Kawabata, T. Kawase, K. Hirose, Y. Monobe, K.-i. Akagi, R. C. Yanagita and K. Irie* |
Y. Irie, M. Hanaki, K. Murakami, T. Imamoto, T. Furuta, T. Kawabata, T. Kawase, K. Hirose, Y. Monobe, K.-i. Akagi, R. C. Yanagita and K. Irie* |
Synthesis and biochemical characterization of quasi-stable trimer models of full-length amyloid beta40 with a toxic conformation |
Synthesis and biochemical characterization of quasi-stable trimer models of full-length amyloid beta40 with a toxic conformation |
Synthesis and biochemical characterization of quasi-stable trimer models of full-length amyloid beta40 with a toxic conformation |
Chem. Commun., 55, 182-185 |
Chem. Commun., 55, 182-185 |
Chem. Commun., 55, 182-185 |
2019 |
Refereed |
English |
Research paper(scientific journal) |
Disclose to all |
C. Valentine, K. Ohnishi, K. Irie and A. Murakami* |
C. Valentine, K. Ohnishi, K. Irie and A. Murakami* |
C. Valentine, K. Ohnishi, K. Irie and A. Murakami* |
Curcumin may induce lipolysis via proteo-stress in Huh7 human hepatoma cells |
Curcumin may induce lipolysis via proteo-stress in Huh7 human hepatoma cells |
Curcumin may induce lipolysis via proteo-stress in Huh7 human hepatoma cells |
J. Clin. Biochem. Nutr., 65, 2, 91-98 |
J. Clin. Biochem. Nutr., 65, 2, 91-98 |
J. Clin. Biochem. Nutr., 65, 2, 91-98 |
2019 |
Refereed |
English |
Research paper(scientific journal) |
Disclose to all |
K. Irie |
入江一浩 |
K. Irie |
分子模型 |
分子模型 |
分子模型 |
化学と生物, 57, 5, 263-263 |
化学と生物, 57, 5, 263-263 |
化学と生物, 57, 5, 263-263 |
2019 |
|
Japanese |
Research paper(scientific journal) |
Disclose to all |
K. Murakami* and K. Irie* |
K. Murakami* and K. Irie* |
K. Murakami* and K. Irie* |
Three structural features of functional food components and herbal medicine with amyloid β42 anti-aggregation properties |
Three structural features of functional food components and herbal medicine with amyloid β42 anti-aggregation properties |
Three structural features of functional food components and herbal medicine with amyloid β42 anti-aggregation properties |
Molecules, 24, 2125 |
Molecules, 24, 2125 |
Molecules, 24, 2125 |
2019 |
Refereed |
English |
Research paper(scientific journal) |
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Y. Hanaki, Y. Shikata, M. Kikumori, N. Hotta, M. Imoto and K. Irie* |
Y. Hanaki, Y. Shikata, M. Kikumori, N. Hotta, M. Imoto and K. Irie* |
Y. Hanaki, Y. Shikata, M. Kikumori, N. Hotta, M. Imoto and K. Irie* |
Identification of protein kinase C isozymes involved in the anti-proliferative and pro-apoptotic activities of 10-methyl-aplog-1, a simplified analog of debromoaplysiatoxin, in several cancer cell lines |
Identification of protein kinase C isozymes involved in the anti-proliferative and pro-apoptotic activities of 10-methyl-aplog-1, a simplified analog of debromoaplysiatoxin, in several cancer cell lines |
Identification of protein kinase C isozymes involved in the anti-proliferative and pro-apoptotic activities of 10-methyl-aplog-1, a simplified analog of debromoaplysiatoxin, in several cancer cell lines |
Biochem. Biophys. Res. Commun., 495, 1, 438-445 |
Biochem. Biophys. Res. Commun., 495, 1, 438-445 |
Biochem. Biophys. Res. Commun., 495, 1, 438-445 |
2018 |
Refereed |
English |
Research paper(scientific journal) |
Disclose to all |
泉尾直孝*,清水孝彦,村上一馬,入江一浩 |
泉尾直孝*,清水孝彦,村上一馬,入江一浩 |
泉尾直孝*,清水孝彦,村上一馬,入江一浩 |
アミロイドβ「毒性コンホマー」を標的にしたアルツハイマー病の治療・診断法の開発 |
アミロイドβ「毒性コンホマー」を標的にしたアルツハイマー病の治療・診断法の開発 |
アミロイドβ「毒性コンホマー」を標的にしたアルツハイマー病の治療・診断法の開発 |
医薬品医療機器レギュラトリーサイエンス, 49, 5, 312-318 |
医薬品医療機器レギュラトリーサイエンス, 49, 5, 312-318 |
医薬品医療機器レギュラトリーサイエンス, 49, 5, 312-318 |
2018 |
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Japanese |
Research paper(scientific journal) |
Disclose to all |
Y. Kageyama, A. Saito, O. Pletnikova, G. L. Rudow, Y. Irie, Y. An, K. Murakami, K. Irie, S. M. Resnick, D. R. Fowler, L. J. Martin and J. C. Troncoso* |
Y. Kageyama, A. Saito, O. Pletnikova, G. L. Rudow, Y. Irie, Y. An, K. Murakami, K. Irie, S. M. Resnick, D. R. Fowler, L. J. Martin and J. C. Troncoso* |
Y. Kageyama, A. Saito, O. Pletnikova, G. L. Rudow, Y. Irie, Y. An, K. Murakami, K. Irie, S. M. Resnick, D. R. Fowler, L. J. Martin and J. C. Troncoso* |
Amylod beta toxic conformer has dynamic localization in the human inferior parietal cortex in absence of amyloid plaques |
Amylod beta toxic conformer has dynamic localization in the human inferior parietal cortex in absence of amyloid plaques |
Amylod beta toxic conformer has dynamic localization in the human inferior parietal cortex in absence of amyloid plaques |
Sci. Rep., 8, 16895 |
Sci. Rep., 8, 16895 |
Sci. Rep., 8, 16895 |
2018 |
Refereed |
English |
Research paper(scientific journal) |
Disclose to all |
M. Hanaki, K. Murakami, S. Katayama, K.-i. Akagi and K. Irie* |
M. Hanaki, K. Murakami, S. Katayama, K.-i. Akagi and K. Irie* |
M. Hanaki, K. Murakami, S. Katayama, K.-i. Akagi and K. Irie* |
Mechanistic analyses of the suppression of amyloid β42 aggregation by apomorphine |
Mechanistic analyses of the suppression of amyloid β42 aggregation by apomorphine |
Mechanistic analyses of the suppression of amyloid β42 aggregation by apomorphine |
Bioorg. Med. Chem., 26, 8, 1538-1546 |
Bioorg. Med. Chem., 26, 8, 1538-1546 |
Bioorg. Med. Chem., 26, 8, 1538-1546 |
2018 |
Refereed |
English |
Research paper(scientific journal) |
Disclose to all |
K. Murakami, T. Yoshioka, S. Horii, M. Hanaki, S. Midorikawa, S. Taniwaki, H. Gunji, K.-i. Akagi, T. Kawase, K. Hirose and K. Irie* |
K. Murakami, T. Yoshioka, S. Horii, M. Hanaki, S. Midorikawa, S. Taniwaki, H. Gunji, K.-i. Akagi, T. Kawase, K. Hirose and K. Irie* |
K. Murakami, T. Yoshioka, S. Horii, M. Hanaki, S. Midorikawa, S. Taniwaki, H. Gunji, K.-i. Akagi, T. Kawase, K. Hirose and K. Irie* |
Role of the carboxy groups of triterpenoids in their inhibition of the nucleation of amyloid β42 required for forming toxic oligomers |
Role of the carboxy groups of triterpenoids in their inhibition of the nucleation of amyloid β42 required for forming toxic oligomers |
Role of the carboxy groups of triterpenoids in their inhibition of the nucleation of amyloid β42 required for forming toxic oligomers |
Chem. Commun., 54, 6272-6275 |
Chem. Commun., 54, 6272-6275 |
Chem. Commun., 54, 6272-6275 |
2018 |
Refereed |
English |
Research paper(scientific journal) |
Disclose to all |
K. Hayakawa, Y. Hanaki, H. Tokuda, R. C. Yanagita, Y. Nakagawa, M. Okamura, S. Dan and K. Irie* |
K. Hayakawa, Y. Hanaki, H. Tokuda, R. C. Yanagita, Y. Nakagawa, M. Okamura, S. Dan and K. Irie* |
K. Hayakawa, Y. Hanaki, H. Tokuda, R. C. Yanagita, Y. Nakagawa, M. Okamura, S. Dan and K. Irie* |
Synthesis and biological activities of acetal analogs at position 3 of 10-methyl-aplog-1, a potential anti-cancer lead derived from debromoaplysiatoxin |
Synthesis and biological activities of acetal analogs at position 3 of 10-methyl-aplog-1, a potential anti-cancer lead derived from debromoaplysiatoxin |
Synthesis and biological activities of acetal analogs at position 3 of 10-methyl-aplog-1, a potential anti-cancer lead derived from debromoaplysiatoxin |
Heterocycles, 97, 1, 478-492 |
Heterocycles, 97, 1, 478-492 |
Heterocycles, 97, 1, 478-492 |
2018 |
Refereed |
English |
Research paper(scientific journal) |
Disclose to all |
C. Akiba*, M. Nakajima, M. Miyajima, I. Ogino, Y. Motoi, K. Kawamura, S. Adachi, A. Kondo, H. Sugano, T. Tokuda, K. Irie and H. Arai |
C. Akiba*, M. Nakajima, M. Miyajima, I. Ogino, Y. Motoi, K. Kawamura, S. Adachi, A. Kondo, H. Sugano, T. Tokuda, K. Irie and H. Arai |
C. Akiba*, M. Nakajima, M. Miyajima, I. Ogino, Y. Motoi, K. Kawamura, S. Adachi, A. Kondo, H. Sugano, T. Tokuda, K. Irie and H. Arai |
Change of amyloid-beta 1-42 toxic conformer ratio after cerebrospinal fluid diversion predicts long-term cognitive outcome in patients with idiopathic normal pressure hydrocephalus |
Change of amyloid-beta 1-42 toxic conformer ratio after cerebrospinal fluid diversion predicts long-term cognitive outcome in patients with idiopathic normal pressure hydrocephalus |
Change of amyloid-beta 1-42 toxic conformer ratio after cerebrospinal fluid diversion predicts long-term cognitive outcome in patients with idiopathic normal pressure hydrocephalus |
J. Alzheimers Dis., 63, 3, 989-1002 |
J. Alzheimers Dis., 63, 3, 989-1002 |
J. Alzheimers Dis., 63, 3, 989-1002 |
2018 |
Refereed |
English |
Research paper(scientific journal) |
Disclose to all |
Y. Aihara, A. Kawaguchi, M. Hanaki, K. Murakami, K. Irie and H. Shigemori* |
Y. Aihara, A. Kawaguchi, M. Hanaki, K. Murakami, K. Irie and H. Shigemori* |
Y. Aihara, A. Kawaguchi, M. Hanaki, K. Murakami, K. Irie and H. Shigemori* |
Inhibitory activity of hispidin derivatives isolated from Inonotus obliquus on amyloid β aggregation |
Inhibitory activity of hispidin derivatives isolated from Inonotus obliquus on amyloid β aggregation |
Inhibitory activity of hispidin derivatives isolated from Inonotus obliquus on amyloid β aggregation |
Heterocycles, 94, 7, 1280-1287 |
Heterocycles, 94, 7, 1280-1287 |
Heterocycles, 94, 7, 1280-1287 |
2017 |
Refereed |
English |
Research paper(scientific journal) |
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Y. Oku, K. Murakami, K. Irie, J. Hoseki and Y. Sakai* |
Y. Oku, K. Murakami, K. Irie, J. Hoseki and Y. Sakai* |
Y. Oku, K. Murakami, K. Irie, J. Hoseki and Y. Sakai* |
Synthesized Aβ42 caused intracellular oxidative damage, leading to cell death, via lysosome rupture |
Synthesized Aβ42 caused intracellular oxidative damage, leading to cell death, via lysosome rupture |
Synthesized Aβ42 caused intracellular oxidative damage, leading to cell death, via lysosome rupture |
Cell Struct. Funct., 42, 1, 71-79 |
Cell Struct. Funct., 42, 1, 71-79 |
Cell Struct. Funct., 42, 1, 71-79 |
2017 |
Refereed |
English |
Research paper(scientific journal) |
Disclose to all |
A. Ben Hmidene, M. Hanaki, K. Murakami, K. Irie, H. Isoda and H. Shigemori* |
A. Ben Hmidene, M. Hanaki, K. Murakami, K. Irie, H. Isoda and H. Shigemori* |
A. Ben Hmidene, M. Hanaki, K. Murakami, K. Irie, H. Isoda and H. Shigemori* |
Inhibitory activities of antioxidant favonoids from Tamarix gallica on amyloid aggregation related to Alzheimer's and type 2 diabetes diseases |
Inhibitory activities of antioxidant favonoids from Tamarix gallica on amyloid aggregation related to Alzheimer's and type 2 diabetes diseases |
Inhibitory activities of antioxidant favonoids from Tamarix gallica on amyloid aggregation related to Alzheimer's and type 2 diabetes diseases |
Biol. Pharm. Bull., 40, 238-241 |
Biol. Pharm. Bull., 40, 238-241 |
Biol. Pharm. Bull., 40, 238-241 |
2017 |
Refereed |
English |
Research paper(scientific journal) |
Disclose to all |
K. Kawabata*, K. Kitamura, K. Irie, S. Naruse, T. Matsuura, T. Uemae, S. Taira, H. Ohigashi, S Murakami, M. Takahashi, Y. Kaido and B. Kawakami |
K. Kawabata*, K. Kitamura, K. Irie, S. Naruse, T. Matsuura, T. Uemae, S. Taira, H. Ohigashi, S Murakami, M. Takahashi, Y. Kaido and B. Kawakami |
K. Kawabata*, K. Kitamura, K. Irie, S. Naruse, T. Matsuura, T. Uemae, S. Taira, H. Ohigashi, S Murakami, M. Takahashi, Y. Kaido and B. Kawakami |
Triterpenoids isolated from Ziziphus jujuba enhance glucose uptake activity in skeletal muscle cells |
Triterpenoids isolated from Ziziphus jujuba enhance glucose uptake activity in skeletal muscle cells |
Triterpenoids isolated from Ziziphus jujuba enhance glucose uptake activity in skeletal muscle cells |
J. Nutr. Sci. Vitaminol., 63, 3, 193-199 |
J. Nutr. Sci. Vitaminol., 63, 3, 193-199 |
J. Nutr. Sci. Vitaminol., 63, 3, 193-199 |
2017 |
Refereed |
English |
Research paper(scientific journal) |
Disclose to all |
Y. Hanaki, M. Kikumori, H. Tokuda, M. Okamura, S. Dan, N. Adachi, N. Saito, R. C. Yanagita and K. Irie* |
Y. Hanaki, M. Kikumori, H. Tokuda, M. Okamura, S. Dan, N. Adachi, N. Saito, R. C. Yanagita and K. Irie* |
Y. Hanaki, M. Kikumori, H. Tokuda, M. Okamura, S. Dan, N. Adachi, N. Saito, R. C. Yanagita and K. Irie* |
Loss of the phenolic hydroxyl group and aromaticity from the side chain of anti-proliferative 10-methyl-aplog-1, a simplified analog of aplysiatoxin, enhances its tumor-promoting and proinflammatory activities |
Loss of the phenolic hydroxyl group and aromaticity from the side chain of anti-proliferative 10-methyl-aplog-1, a simplified analog of aplysiatoxin, enhances its tumor-promoting and proinflammatory activities |
Loss of the phenolic hydroxyl group and aromaticity from the side chain of anti-proliferative 10-methyl-aplog-1, a simplified analog of aplysiatoxin, enhances its tumor-promoting and proinflammatory activities |
Molecules, 22, 631 |
Molecules, 22, 631 |
Molecules, 22, 631 |
2017 |
Refereed |
English |
Research paper(scientific journal) |
Disclose to all |
N. Izuo, C. Kasahara, K. Murakami, T. Kume, M. Maeda, K. Irie, K. Yokote and T. Shimizu* |
N. Izuo, C. Kasahara, K. Murakami, T. Kume, M. Maeda, K. Irie, K. Yokote and T. Shimizu* |
N. Izuo, C. Kasahara, K. Murakami, T. Kume, M. Maeda, K. Irie, K. Yokote and T. Shimizu* |
A toxic conformer of Aβ42 with a turn at 22-23 is a novel therapeutic target for Alzheimer’s disease |
A toxic conformer of Aβ42 with a turn at 22-23 is a novel therapeutic target for Alzheimer’s disease |
A toxic conformer of Aβ42 with a turn at 22-23 is a novel therapeutic target for Alzheimer’s disease |
Sci. Rep., 7, 11811 |
Sci. Rep., 7, 11811 |
Sci. Rep., 7, 11811 |
2017 |
Refereed |
English |
Research paper(scientific journal) |
Disclose to all |
Y. Irie, K. Murakami, M. Hanaki, Y. Hanaki, T. Suzuki, Y. Monobe, T. Takai, K. Akagi, T. Kawase, K. Hirose and K. Irie* |
Y. Irie, K. Murakami, M. Hanaki, Y. Hanaki, T. Suzuki, Y. Monobe, T. Takai, K. Akagi, T. Kawase, K. Hirose and K. Irie* |
Y. Irie, K. Murakami, M. Hanaki, Y. Hanaki, T. Suzuki, Y. Monobe, T. Takai, K. Akagi, T. Kawase, K. Hirose and K. Irie* |
Synthetic models of quasi-stable amyloid β40 oligomers with significant neurotoxicity |
Synthetic models of quasi-stable amyloid β40 oligomers with significant neurotoxicity |
Synthetic models of quasi-stable amyloid β40 oligomers with significant neurotoxicity |
ACS Chem. Neurosci., 8, 4, 807-816 |
ACS Chem. Neurosci., 8, 4, 807-816 |
ACS Chem. Neurosci., 8, 4, 807-816 |
2017 |
Refereed |
English |
Research paper(scientific journal) |
Disclose to all |
K. Murakami and K. Irie* |
村上一馬,入江一浩* |
K. Murakami and K. Irie* |
食品・生薬成分によるアミロイドβ42の凝集抑制機構の系統的解析 |
食品・生薬成分によるアミロイドβ42の凝集抑制機構の系統的解析 |
食品・生薬成分によるアミロイドβ42の凝集抑制機構の系統的解析 |
日本認知症学会誌, 31, 3, 351-360 |
日本認知症学会誌, 31, 3, 351-360 |
日本認知症学会誌, 31, 3, 351-360 |
2017 |
|
Japanese |
Research paper(scientific journal) |
Disclose to all |
K. Murakami, M. Tokuda, T. Suzuki, Y. Irie, M. Hanaki, N. Izuo, Y. Monobe, K.-i. Akagi, R. Ishii, H. Tatebe, T. Tokuda, M. Maeda, T. Kume, T. Shimizu and K. Irie* |
K. Murakami, M. Tokuda, T. Suzuki, Y. Irie, M. Hanaki, N. Izuo, Y. Monobe, K.-i. Akagi, R. Ishii, H. Tatebe, T. Tokuda, M. Maeda, T. Kume, T. Shimizu and K. Irie* |
K. Murakami, M. Tokuda, T. Suzuki, Y. Irie, M. Hanaki, N. Izuo, Y. Monobe, K.-i. Akagi, R. Ishii, H. Tatebe, T. Tokuda, M. Maeda, T. Kume, T. Shimizu and K. Irie* |
Monoclonal antibody with conformational specificity for a toxic conformer of amyloid β42 and its application toward the Alzheimer’s disease diagnosis  |
Monoclonal antibody with conformational specificity for a toxic conformer of amyloid β42 and its application toward the Alzheimer’s disease diagnosis  |
Monoclonal antibody with conformational specificity for a toxic conformer of amyloid β42 and its application toward the Alzheimer’s disease diagnosis  |
Sci. Rep., 6, 29038 |
Sci. Rep., 6, 29038 |
Sci. Rep., 6, 29038 |
2016 |
Refereed |
English |
Research paper(scientific journal) |
Disclose to all |
Y. Ashida, R. C. Yanagita*, C. Takahashi, Y. Kawanami and K. Irie |
Y. Ashida, R. C. Yanagita*, C. Takahashi, Y. Kawanami and K. Irie |
Y. Ashida, R. C. Yanagita*, C. Takahashi, Y. Kawanami and K. Irie |
Binding mode prediction of aplysiatoxin, a potent agonist of protein kinase C, through molecular simulation and structure-activity study on simplified analogs of the receptor-recognition domain |
Binding mode prediction of aplysiatoxin, a potent agonist of protein kinase C, through molecular simulation and structure-activity study on simplified analogs of the receptor-recognition domain |
Binding mode prediction of aplysiatoxin, a potent agonist of protein kinase C, through molecular simulation and structure-activity study on simplified analogs of the receptor-recognition domain |
Bioorg. Med. Chem., 24, 18, 4218-4227 |
Bioorg. Med. Chem., 24, 18, 4218-4227 |
Bioorg. Med. Chem., 24, 18, 4218-4227 |
2016 |
Refereed |
English |
Research paper(scientific journal) |
Disclose to all |
E. Kidachi, M. Kurisu, Y. Miyamae, M. Hanaki, K. Murakami, K. Irie and H. Shigemori* |
E. Kidachi, M. Kurisu, Y. Miyamae, M. Hanaki, K. Murakami, K. Irie and H. Shigemori* |
E. Kidachi, M. Kurisu, Y. Miyamae, M. Hanaki, K. Murakami, K. Irie and H. Shigemori* |
Structure-activity relationship of phenylethanoid glycosides on the inhibition of amyloid β aggregation |
Structure-activity relationship of phenylethanoid glycosides on the inhibition of amyloid β aggregation |
Structure-activity relationship of phenylethanoid glycosides on the inhibition of amyloid β aggregation |
Heterocycles, 92, 11, 1976-1982 |
Heterocycles, 92, 11, 1976-1982 |
Heterocycles, 92, 11, 1976-1982 |
2016 |
Refereed |
English |
Research paper(scientific journal) |
Disclose to all |
Y. Igarashi, K. Ohnishi, K. Irie and A. Murakami* |
Y. Igarashi, K. Ohnishi, K. Irie and A. Murakami* |
Y. Igarashi, K. Ohnishi, K. Irie and A. Murakami* |
Possible contribution of zerumbone-Induced proteo-stress to its anti-inflammatory functions via the activation of heat shock factor 1  |
Possible contribution of zerumbone-Induced proteo-stress to its anti-inflammatory functions via the activation of heat shock factor 1  |
Possible contribution of zerumbone-Induced proteo-stress to its anti-inflammatory functions via the activation of heat shock factor 1  |
PLos One, 11, 8, e0161282 |
PLos One, 11, 8, e0161282 |
PLos One, 11, 8, e0161282 |
2016 |
Refereed |
English |
Research paper(scientific journal) |
Disclose to all |
T. Yoshioka, K. Murakami, K. Ido, M. Hanaki, K. Yamaguchi, S. Midorikawa, S. Taniwaki, H. Gunji and K. Irie* |
T. Yoshioka, K. Murakami, K. Ido, M. Hanaki, K. Yamaguchi, S. Midorikawa, S. Taniwaki, H. Gunji and K. Irie* |
T. Yoshioka, K. Murakami, K. Ido, M. Hanaki, K. Yamaguchi, S. Midorikawa, S. Taniwaki, H. Gunji and K. Irie* |
Semisynthesis and structure–activity studies of Uncarinic acid C Isolated from Uncaria rhynchophylla as a specific inhibitor of the nucleation phase in amyloid β42 aggregation |
Semisynthesis and structure–activity studies of Uncarinic acid C Isolated from Uncaria rhynchophylla as a specific inhibitor of the nucleation phase in amyloid β42 aggregation |
Semisynthesis and structure–activity studies of Uncarinic acid C Isolated from Uncaria rhynchophylla as a specific inhibitor of the nucleation phase in amyloid β42 aggregation |
J. Nat. Prod., 79, 10, 2521-2529 |
J. Nat. Prod., 79, 10, 2521-2529 |
J. Nat. Prod., 79, 10, 2521-2529 |
2016 |
Refereed |
English |
Research paper(scientific journal) |
Disclose to all |
M. Kikumori, R. C. Yanagita, H. Tokuda, K. Suenaga, H. Nagai and K. Irie* |
M. Kikumori, R. C. Yanagita, H. Tokuda, K. Suenaga, H. Nagai and K. Irie* |
M. Kikumori, R. C. Yanagita, H. Tokuda, K. Suenaga, H. Nagai and K. Irie* |
Structural optimization of 10-methyl-aplog-1, a simplified analog of debromoaplysiatoxin, as an anticancer lead |
Structural optimization of 10-methyl-aplog-1, a simplified analog of debromoaplysiatoxin, as an anticancer lead |
Structural optimization of 10-methyl-aplog-1, a simplified analog of debromoaplysiatoxin, as an anticancer lead |
Biosci. Biotechnol. Biochem., 80, 2, 221-231 |
Biosci. Biotechnol. Biochem., 80, 2, 221-231 |
Biosci. Biotechnol. Biochem., 80, 2, 221-231 |
2016 |
Refereed |
English |
Research paper(scientific journal) |
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IRIE Kazuhiro |
入江一浩 |
IRIE Kazuhiro |
アルツハイマー病の正確な早期診断の実現に向けて |
アルツハイマー病の正確な早期診断の実現に向けて |
アルツハイマー病の正確な早期診断の実現に向けて |
化学, 71, 11, 41-44 |
化学, 71, 11, 41-44 |
化学, 71, 11, 41-44 |
2016 |
|
Japanese |
Research paper(scientific journal) |
Disclose to all |
M. Hanaki, K. Murakami, K.-i. Akagi and K. Irie* |
M. Hanaki, K. Murakami, K.-i. Akagi and K. Irie* |
M. Hanaki, K. Murakami, K.-i. Akagi and K. Irie* |
Structural insights into mechanisms for inhibiting amyloid β42 aggregation by non-catechol-type flavonoids |
Structural insights into mechanisms for inhibiting amyloid β42 aggregation by non-catechol-type flavonoids |
Structural insights into mechanisms for inhibiting amyloid β42 aggregation by non-catechol-type flavonoids |
Bioorg. Med. Chem., 24, 2, 313 |
Bioorg. Med. Chem., 24, 2, 313 |
Bioorg. Med. Chem., 24, 2, 313 |
2016 |
Refereed |
English |
Research paper(scientific journal) |
Disclose to all |
H. Takahashi, N. Adachi, T. Shirafuji, S. Danno, T. Ueyama, M. Vendruscolo, A. N. Shuvaev, T. Sugimoto, T. Seki, D. Hamada, K. Irie, H. Hirai, N. Sakai and N. Saito* |
H. Takahashi, N. Adachi, T. Shirafuji, S. Danno, T. Ueyama, M. Vendruscolo, A. N. Shuvaev, T. Sugimoto, T. Seki, D. Hamada, K. Irie, H. Hirai, N. Sakai and N. Saito* |
H. Takahashi, N. Adachi, T. Shirafuji, S. Danno, T. Ueyama, M. Vendruscolo, A. N. Shuvaev, T. Sugimoto, T. Seki, D. Hamada, K. Irie, H. Hirai, N. Sakai and N. Saito* |
Identification and characterization of PKCgamma, implicated in SCA14, as an amyloidogenic protein |
Identification and characterization of PKCgamma, implicated in SCA14, as an amyloidogenic protein |
Identification and characterization of PKCgamma, implicated in SCA14, as an amyloidogenic protein |
Human Mol. Genet., 24, 2, 525-539 |
Human Mol. Genet., 24, 2, 525-539 |
Human Mol. Genet., 24, 2, 525-539 |
2015 |
Refereed |
English |
Research paper(scientific journal) |
Disclose to all |
泉尾直孝*,村上一馬,久米利明,前田雅弘,入江一浩,清水孝彦 |
泉尾直孝*,村上一馬,久米利明,前田雅弘,入江一浩,清水孝彦 |
|
アルツハイマー病様神経毒性におけるアミロイドβコンホマーの役割 |
アルツハイマー病様神経毒性におけるアミロイドβコンホマーの役割 |
|
基礎老化研究, 39, 3, 29-34 |
基礎老化研究, 39, 3, 29-34 |
, 39, 3, 29-34 |
2015 |
|
Japanese |
Research paper(scientific journal) |
Disclose to all |
A. Otera, Y. Miyamae*, K. Yoshida, K. Mejima, T. Akita, A. Kakizuka, K. Irie, S. Masuda, T. Kambe and M. Nagao |
A. Otera, Y. Miyamae*, K. Yoshida, K. Mejima, T. Akita, A. Kakizuka, K. Irie, S. Masuda, T. Kambe and M. Nagao |
A. Otera, Y. Miyamae*, K. Yoshida, K. Mejima, T. Akita, A. Kakizuka, K. Irie, S. Masuda, T. Kambe and M. Nagao |
Identification of a new type of covalent PPARγ agonist using a ligand-linking strategy |
Identification of a new type of covalent PPARγ agonist using a ligand-linking strategy |
Identification of a new type of covalent PPARγ agonist using a ligand-linking strategy |
ACS Chem. Biol., 10, 12, 2794-2804 |
ACS Chem. Biol., 10, 12, 2794-2804 |
ACS Chem. Biol., 10, 12, 2794-2804 |
2015 |
Refereed |
English |
Research paper(scientific journal) |
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Y. Hanaki, R. C. Yanagita, T. Sugahara, M. Aida, H. Tokuda, N. Suzuki and K. Irie* |
Y. Hanaki, R. C. Yanagita, T. Sugahara, M. Aida, H. Tokuda, N. Suzuki and K. Irie* |
Y. Hanaki, R. C. Yanagita, T. Sugahara, M. Aida, H. Tokuda, N. Suzuki and K. Irie* |
Synthesis and biological activities of the amide derivative of aplog-1, a simplified analog of aplysiatoxin with anti-proliferative and cytotoxic activities  |
Synthesis and biological activities of the amide derivative of aplog-1, a simplified analog of aplysiatoxin with anti-proliferative and cytotoxic activities  |
Synthesis and biological activities of the amide derivative of aplog-1, a simplified analog of aplysiatoxin with anti-proliferative and cytotoxic activities  |
Biosci. Biotechnol. Biochem., 79, 6, 888-895 |
Biosci. Biotechnol. Biochem., 79, 6, 888-895 |
Biosci. Biotechnol. Biochem., 79, 6, 888-895 |
2015 |
Refereed |
English |
Research paper(scientific journal) |
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A. Hashimoto, K. Ohkura, M. Takahashi, K. Kizu, H. Narita, S. Enomoto, Y. Miyamae, S. Masuda, M. Nagao, K. Irie, H. Ohigashi, G. K. Andrews, and T. Kambe* |
A. Hashimoto, K. Ohkura, M. Takahashi, K. Kizu, H. Narita, S. Enomoto, Y. Miyamae, S. Masuda, M. Nagao, K. Irie, H. Ohigashi, G. K. Andrews, and T. Kambe* |
A. Hashimoto, K. Ohkura, M. Takahashi, K. Kizu, H. Narita, S. Enomoto, Y. Miyamae, S. Masuda, M. Nagao, K. Irie, H. Ohigashi, G. K. Andrews, and T. Kambe* |
Soybean extracts increase cell surface ZIP4 abundance and cellular zinc levels: a potential novel strategy to enhance zinc absorption by ZIP4-targeting  |
Soybean extracts increase cell surface ZIP4 abundance and cellular zinc levels: a potential novel strategy to enhance zinc absorption by ZIP4-targeting  |
Soybean extracts increase cell surface ZIP4 abundance and cellular zinc levels: a potential novel strategy to enhance zinc absorption by ZIP4-targeting  |
Biochem. J., 472, 2, 183-193 |
Biochem. J., 472, 2, 183-193 |
Biochem. J., 472, 2, 183-193 |
2015 |
Refereed |
English |
Research paper(scientific journal) |
Disclose to all |
K. Murakami, T. Suzuki, M. Hanaki, Y. Monobe, K.-i. Akagi and K. Irie* |
K. Murakami, T. Suzuki, M. Hanaki, Y. Monobe, K.-i. Akagi and K. Irie* |
K. Murakami, T. Suzuki, M. Hanaki, Y. Monobe, K.-i. Akagi and K. Irie* |
Synthesis and characterization of the amyloid β40 dimer model with a linker at position 30 adjacent to the intermolecular β-sheet region  |
Synthesis and characterization of the amyloid β40 dimer model with a linker at position 30 adjacent to the intermolecular β-sheet region  |
Synthesis and characterization of the amyloid β40 dimer model with a linker at position 30 adjacent to the intermolecular β-sheet region  |
Biochem. Biophys. Res. Commun., 466, 3, 463-467 |
Biochem. Biophys. Res. Commun., 466, 3, 463-467 |
Biochem. Biophys. Res. Commun., 466, 3, 463-467 |
2015 |
Refereed |
English |
Research paper(scientific journal) |
Disclose to all |
M. Kikumori, R. C. Yanagita and K. Irie* |
M. Kikumori, R. C. Yanagita and K. Irie* |
M. Kikumori, R. C. Yanagita and K. Irie* |
Improved and large-scale synthesis of 10-methyl-aplog-1, a potential lead for an anticancer drug  |
Improved and large-scale synthesis of 10-methyl-aplog-1, a potential lead for an anticancer drug  |
Improved and large-scale synthesis of 10-methyl-aplog-1, a potential lead for an anticancer drug  |
Tetrahedron, 70, 52, 9776-9782 |
Tetrahedron, 70, 52, 9776-9782 |
Tetrahedron, 70, 52, 9776-9782 |
2014 |
Refereed |
English |
Research paper(scientific journal) |
Disclose to all |
W. Jiang, S. Tan, Y. Hanaki, K. Irie, H. Uchida, R. Watanabe, T. Suzuki, B. Sakamoto, M. Kamio and H. Nagai* |
W. Jiang, S. Tan, Y. Hanaki, K. Irie, H. Uchida, R. Watanabe, T. Suzuki, B. Sakamoto, M. Kamio and H. Nagai* |
W. Jiang, S. Tan, Y. Hanaki, K. Irie, H. Uchida, R. Watanabe, T. Suzuki, B. Sakamoto, M. Kamio and H. Nagai* |
Two new lyngbyatoxin derivatives from the cyanobacterium Moorea producens |
Two new lyngbyatoxin derivatives from the cyanobacterium Moorea producens |
Two new lyngbyatoxin derivatives from the cyanobacterium Moorea producens |
Mar. Drugs, 12, 5788-5800 |
Mar. Drugs, 12, 5788-5800 |
Mar. Drugs, 12, 5788-5800 |
2014 |
Refereed |
English |
Research paper(scientific journal) |
Disclose to all |
K. Irie* and R. C. Yanagita |
K. Irie* and R. C. Yanagita |
K. Irie* and R. C. Yanagita |
Synthesis and biological activities of the simplified analogs of natural PKC ligands, bryostatin-1 and aplysiatoxin  |
Synthesis and biological activities of the simplified analogs of natural PKC ligands, bryostatin-1 and aplysiatoxin  |
Synthesis and biological activities of the simplified analogs of natural PKC ligands, bryostatin-1 and aplysiatoxin  |
Chem. Rec., 14, 2, 251-267 |
Chem. Rec., 14, 2, 251-267 |
Chem. Rec., 14, 2, 251-267 |
2014 |
Refereed |
English |
Research paper(scientific journal) |
Disclose to all |
W. Jiang, W. Zhou, H. Uchida, M. Kikumori, K. Irie, R. Watanabe, T. Suzuki, B. Sakamoto, M. Kamino and H. Nagai* |
W. Jiang, W. Zhou, H. Uchida, M. Kikumori, K. Irie, R. Watanabe, T. Suzuki, B. Sakamoto, M. Kamino and H. Nagai* |
W. Jiang, W. Zhou, H. Uchida, M. Kikumori, K. Irie, R. Watanabe, T. Suzuki, B. Sakamoto, M. Kamino and H. Nagai* |
A new lyngbyatoxin from the Hawaiian cyanobacterium moorea producens |
A new lyngbyatoxin from the Hawaiian cyanobacterium moorea producens |
A new lyngbyatoxin from the Hawaiian cyanobacterium moorea producens |
Mar. Drugs, 12, 5, 2748-2759 |
Mar. Drugs, 12, 5, 2748-2759 |
Mar. Drugs, 12, 5, 2748-2759 |
2014 |
Refereed |
English |
Research paper(scientific journal) |
Disclose to all |
A. Ohtera, Y. Miyamae, N. Nakai, A. Kawachi, K. Kawada, J. Han, H. Isoda, M. Neffati, T. Akita, K. Maejima, S. Masuda, T. Kambe, N. Mori, K. Irie and M. Nagao* |
A. Ohtera, Y. Miyamae, N. Nakai, A. Kawachi, K. Kawada, J. Han, H. Isoda, M. Neffati, T. Akita, K. Maejima, S. Masuda, T. Kambe, N. Mori, K. Irie and M. Nagao* |
A. Ohtera, Y. Miyamae, N. Nakai, A. Kawachi, K. Kawada, J. Han, H. Isoda, M. Neffati, T. Akita, K. Maejima, S. Masuda, T. Kambe, N. Mori, K. Irie and M. Nagao* |
Identification of 6-octadecynoic acid from a methanol extract of Marrubium vulgare L. as a peroxisome proliferator-activated receptor gamma agonist |
Identification of 6-octadecynoic acid from a methanol extract of Marrubium vulgare L. as a peroxisome proliferator-activated receptor gamma agonist |
Identification of 6-octadecynoic acid from a methanol extract of Marrubium vulgare L. as a peroxisome proliferator-activated receptor gamma agonist |
Biochem. Biophys. Res. Commun., 440, 2, 204-209 |
Biochem. Biophys. Res. Commun., 440, 2, 204-209 |
Biochem. Biophys. Res. Commun., 440, 2, 204-209 |
2013 |
Refereed |
English |
Research paper(scientific journal) |
Disclose to all |
K. Ohnishi, S. Ohkura, E. Nakahata, A. Ishisaka, Y. Kawai, J. Terao, T. Mori, T. Ishii, T. Nakayama, N. Kioka, S. Matsumoto, Y. Ikeda, M. Akiyama, K. Irie and A. Murakami* |
K. Ohnishi, S. Ohkura, E. Nakahata, A. Ishisaka, Y. Kawai, J. Terao, T. Mori, T. Ishii, T. Nakayama, N. Kioka, S. Matsumoto, Y. Ikeda, M. Akiyama, K. Irie and A. Murakami* |
K. Ohnishi, S. Ohkura, E. Nakahata, A. Ishisaka, Y. Kawai, J. Terao, T. Mori, T. Ishii, T. Nakayama, N. Kioka, S. Matsumoto, Y. Ikeda, M. Akiyama, K. Irie and A. Murakami* |
Non-specific protein modifications by a phytochemical induce heat shock response for self-defense |
Non-specific protein modifications by a phytochemical induce heat shock response for self-defense |
Non-specific protein modifications by a phytochemical induce heat shock response for self-defense |
PLos One, 8, 3, e58641 |
PLos One, 8, 3, e58641 |
PLos One, 8, 3, e58641 |
2013 |
Refereed |
English |
Research paper(scientific journal) |
Disclose to all |
K. Ohnishi, E. Nakahata, K. Irie and A. Murakami* |
K. Ohnishi, E. Nakahata, K. Irie and A. Murakami* |
K. Ohnishi, E. Nakahata, K. Irie and A. Murakami* |
Zerumbone, an electrophilic sesquiterpene, induces cellular proteo-stress leading to activation of ubiquitin-proteasome system and autophagy |
Zerumbone, an electrophilic sesquiterpene, induces cellular proteo-stress leading to activation of ubiquitin-proteasome system and autophagy |
Zerumbone, an electrophilic sesquiterpene, induces cellular proteo-stress leading to activation of ubiquitin-proteasome system and autophagy |
Biochem. Biophys. Res. Commun., 430, 2, 616-622 |
Biochem. Biophys. Res. Commun., 430, 2, 616-622 |
Biochem. Biophys. Res. Commun., 430, 2, 616-622 |
2013 |
Refereed |
English |
Research paper(scientific journal) |
Disclose to all |
N. Soejima, Y. Ohyagi*, N. Nakamura, E. Himeno, K. M. Iimura, N. Sakae, R. Yamasaki, T. Tabira, K. Murakami, K. Irie, N. Kinoshita, F. M. Laferla, Y. Kiyohara, T. Iwaki and J.-i. Kira |
N. Soejima, Y. Ohyagi*, N. Nakamura, E. Himeno, K. M. Iimura, N. Sakae, R. Yamasaki, T. Tabira, K. Murakami, K. Irie, N. Kinoshita, F. M. Laferla, Y. Kiyohara, T. Iwaki and J.-i. Kira |
N. Soejima, Y. Ohyagi*, N. Nakamura, E. Himeno, K. M. Iimura, N. Sakae, R. Yamasaki, T. Tabira, K. Murakami, K. Irie, N. Kinoshita, F. M. Laferla, Y. Kiyohara, T. Iwaki and J.-i. Kira |
Intracellular accumulation of toxic turn amyloid-β is associated with endoplasmic reticulum stress in Alzheimer’s disease |
Intracellular accumulation of toxic turn amyloid-β is associated with endoplasmic reticulum stress in Alzheimer’s disease |
Intracellular accumulation of toxic turn amyloid-β is associated with endoplasmic reticulum stress in Alzheimer’s disease |
Curr. Alzheimer Res., 10, 1, 11-20 |
Curr. Alzheimer Res., 10, 1, 11-20 |
Curr. Alzheimer Res., 10, 1, 11-20 |
2013 |
Refereed |
English |
Research paper(scientific journal) |
Disclose to all |
Y. Hanaki, M. Kikumori, S. Ueno, H. Tokuda, N. Suzuki and K. Irie* |
Y. Hanaki, M. Kikumori, S. Ueno, H. Tokuda, N. Suzuki and K. Irie* |
Y. Hanaki, M. Kikumori, S. Ueno, H. Tokuda, N. Suzuki and K. Irie* |
Structure-activity studies at position 27 of aplog-1, a simplified analog of debromoaplysiatoxin with anti-proliferative activity |
Structure-activity studies at position 27 of aplog-1, a simplified analog of debromoaplysiatoxin with anti-proliferative activity |
Structure-activity studies at position 27 of aplog-1, a simplified analog of debromoaplysiatoxin with anti-proliferative activity |
Tetrahedron, 69, 36, 7636-7645 |
Tetrahedron, 69, 36, 7636-7645 |
Tetrahedron, 69, 36, 7636-7645 |
2013 |
Refereed |
English |
Research paper(scientific journal) |
Disclose to all |
M. Sato, K. Murakami, M. Uno, H. Ikubo, Y. Nakagawa, S. Katayama, K.-i. Akagi and K. Irie* |
M. Sato, K. Murakami, M. Uno, H. Ikubo, Y. Nakagawa, S. Katayama, K.-i. Akagi and K. Irie* |
M. Sato, K. Murakami, M. Uno, H. Ikubo, Y. Nakagawa, S. Katayama, K.-i. Akagi and K. Irie* |
Structure–activity relationship of (+)-taxifolin isolated from silymarin as an inhibitor of amyloid β aggregation. |
Structure–activity relationship of (+)-taxifolin isolated from silymarin as an inhibitor of amyloid β aggregation. |
Structure–activity relationship of (+)-taxifolin isolated from silymarin as an inhibitor of amyloid β aggregation. |
Biosci. Biotechnol. Biochem., 77, 5, 1100-1103 |
Biosci. Biotechnol. Biochem., 77, 5, 1100-1103 |
Biosci. Biotechnol. Biochem., 77, 5, 1100-1103 |
2013 |
Refereed |
English |
Research paper(scientific journal) |
Disclose to all |
T. Kondo, N. Iwata*, S. Yamanaka, H. Inoue* et al. |
T. Kondo, N. Iwata*, S. Yamanaka, H. Inoue* et al. |
T. Kondo, N. Iwata*, S. Yamanaka, H. Inoue* et al. |
Modeling Alzheimer's disease with iPSCs reveals stress phenotypes associated with intracellular Abeta and differential drug responsiveness |
Modeling Alzheimer's disease with iPSCs reveals stress phenotypes associated with intracellular Abeta and differential drug responsiveness |
Modeling Alzheimer's disease with iPSCs reveals stress phenotypes associated with intracellular Abeta and differential drug responsiveness |
Cell Stem Cell, 12, 4, 487-496 |
Cell Stem Cell, 12, 4, 487-496 |
Cell Stem Cell, 12, 4, 487-496 |
2013 |
Refereed |
English |
Research paper(scientific journal) |
Disclose to all |
H. Kamachi, K. Tanaka, R. C. Yanagita, A. Murakami, K. Murakami, H. Tokuda, N. Suzuki, Y. Nakagawa and K. Irie* |
H. Kamachi, K. Tanaka, R. C. Yanagita, A. Murakami, K. Murakami, H. Tokuda, N. Suzuki, Y. Nakagawa and K. Irie* |
H. Kamachi, K. Tanaka, R. C. Yanagita, A. Murakami, K. Murakami, H. Tokuda, N. Suzuki, Y. Nakagawa and K. Irie* |
Structure-activity studies on the side chain of a simplified analog of aplysiatoxin (aplog-1) with anti-proliferative activity |
Structure-activity studies on the side chain of a simplified analog of aplysiatoxin (aplog-1) with anti-proliferative activity |
Structure-activity studies on the side chain of a simplified analog of aplysiatoxin (aplog-1) with anti-proliferative activity |
Bioorg. Med. Chem., 21, 10, 2695-2702 |
Bioorg. Med. Chem., 21, 10, 2695-2702 |
Bioorg. Med. Chem., 21, 10, 2695-2702 |
2013 |
Refereed |
English |
Research paper(scientific journal) |
Disclose to all |
N. Izuo, K. Murakami, M. Sato, M. Iwasaki, Y. Izumi, T. Shimizu, A. Akaike, K. Irie* and T. Kume* |
N. Izuo, K. Murakami, M. Sato, M. Iwasaki, Y. Izumi, T. Shimizu, A. Akaike, K. Irie* and T. Kume* |
N. Izuo, K. Murakami, M. Sato, M. Iwasaki, Y. Izumi, T. Shimizu, A. Akaike, K. Irie* and T. Kume* |
Non-toxic conformer of amyloid β may suppress amyloid β-induced toxicity in rat primary neurons: implications for a novel therapeutic strategy for Alzheimer's disease |
Non-toxic conformer of amyloid β may suppress amyloid β-induced toxicity in rat primary neurons: implications for a novel therapeutic strategy for Alzheimer's disease |
Non-toxic conformer of amyloid β may suppress amyloid β-induced toxicity in rat primary neurons: implications for a novel therapeutic strategy for Alzheimer's disease |
Biochem. Biophys. Res. Commun., 438, 1, 1-5 |
Biochem. Biophys. Res. Commun., 438, 1, 1-5 |
Biochem. Biophys. Res. Commun., 438, 1, 1-5 |
2013 |
Refereed |
English |
Research paper(scientific journal) |
Disclose to all |
R. C. Yanagita, H. Kamachi, M. Kikumori, H. Tokuda, N. Suzuki, K. Suenaga, H. Nagai and K. Irie* |
R. C. Yanagita, H. Kamachi, M. Kikumori, H. Tokuda, N. Suzuki, K. Suenaga, H. Nagai and K. Irie* |
R. C. Yanagita, H. Kamachi, M. Kikumori, H. Tokuda, N. Suzuki, K. Suenaga, H. Nagai and K. Irie* |
Effects of the methoxy group in the side chain of debromoaplysiatoxin on its tumor-promoting and anti-proliferative activities |
Effects of the methoxy group in the side chain of debromoaplysiatoxin on its tumor-promoting and anti-proliferative activities |
Effects of the methoxy group in the side chain of debromoaplysiatoxin on its tumor-promoting and anti-proliferative activities |
Bioorg. Med. Chem. Lett., 23, 15, 4319-4323 |
Bioorg. Med. Chem. Lett., 23, 15, 4319-4323 |
Bioorg. Med. Chem. Lett., 23, 15, 4319-4323 |
2013 |
Refereed |
English |
Research paper(scientific journal) |
Disclose to all |
M. Sato, K. Murakami, M. Uno, Y. Nakagawa, S. Katayama, K.-i. Akagi, Y. Masuda, K. Takegoshi and K. Irie* |
M. Sato, K. Murakami, M. Uno, Y. Nakagawa, S. Katayama, K.-i. Akagi, Y. Masuda, K. Takegoshi and K. Irie* |
M. Sato, K. Murakami, M. Uno, Y. Nakagawa, S. Katayama, K.-i. Akagi, Y. Masuda, K. Takegoshi and K. Irie* |
Site-specific inhibitory mechanism for amyloid-beta42 aggregation by catechol-type flavonoids targeting the Lys residues  |
Site-specific inhibitory mechanism for amyloid-beta42 aggregation by catechol-type flavonoids targeting the Lys residues  |
Site-specific inhibitory mechanism for amyloid-beta42 aggregation by catechol-type flavonoids targeting the Lys residues  |
J. Biol. Chem., 288, 32, 23212-23224 |
J. Biol. Chem., 288, 32, 23212-23224 |
J. Biol. Chem., 288, 32, 23212-23224 |
2013 |
Refereed |
English |
Research paper(scientific journal) |
Disclose to all |
H. Sekiguchi, F. Takabayashi, K. Irie and A. Murakami* |
H. Sekiguchi, F. Takabayashi, K. Irie and A. Murakami* |
H. Sekiguchi, F. Takabayashi, K. Irie and A. Murakami* |
Auraptene attenuates gastritis via reduction of Helicobacter pylori colonization and pro-inflammatory mediator production in C57BL/6 mice |
Auraptene attenuates gastritis via reduction of Helicobacter pylori colonization and pro-inflammatory mediator production in C57BL/6 mice |
Auraptene attenuates gastritis via reduction of Helicobacter pylori colonization and pro-inflammatory mediator production in C57BL/6 mice |
J. Med. Food, 15, 7, 658-663 |
J. Med. Food, 15, 7, 658-663 |
J. Med. Food, 15, 7, 658-663 |
2012 |
Refereed |
English |
Research paper(scientific journal) |
Disclose to all |
Y. Ikeda, R. Yamaji, K. Irie, N. Kioka and A. Murakami* |
Y. Ikeda, R. Yamaji, K. Irie, N. Kioka and A. Murakami* |
Y. Ikeda, R. Yamaji, K. Irie, N. Kioka and A. Murakami* |
Glyceraldehyde 3-phosphate dehydrogenase regulates cyclooxygenase-2 expression by targeting mRNA stabiliy |
Glyceraldehyde 3-phosphate dehydrogenase regulates cyclooxygenase-2 expression by targeting mRNA stabiliy |
Glyceraldehyde 3-phosphate dehydrogenase regulates cyclooxygenase-2 expression by targeting mRNA stabiliy |
Arch. Biochem. Biophys., 528, 2, 141-147 |
Arch. Biochem. Biophys., 528, 2, 141-147 |
Arch. Biochem. Biophys., 528, 2, 141-147 |
2012 |
Refereed |
English |
Research paper(scientific journal) |
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F. Tsuji, A. Ishihara, K. Kurata, A. Nakagawa, M. Okada, S. Kitamura, K. Kanamaru, Y. Masuda, K. Murakami, K. Irie and Y. Sakagami* |
F. Tsuji, A. Ishihara, K. Kurata, A. Nakagawa, M. Okada, S. Kitamura, K. Kanamaru, Y. Masuda, K. Murakami, K. Irie and Y. Sakagami* |
F. Tsuji, A. Ishihara, K. Kurata, A. Nakagawa, M. Okada, S. Kitamura, K. Kanamaru, Y. Masuda, K. Murakami, K. Irie and Y. Sakagami* |
Geranyl modification on the tryptophan residue of ComXRO-E2 pheromone by a cell-free system |
Geranyl modification on the tryptophan residue of ComXRO-E2 pheromone by a cell-free system |
Geranyl modification on the tryptophan residue of ComXRO-E2 pheromone by a cell-free system |
FEBS Lett., 586, 2, 174-179 |
FEBS Lett., 586, 2, 174-179 |
FEBS Lett., 586, 2, 174-179 |
2012 |
Refereed |
English |
Research paper(scientific journal) |
Disclose to all |
K. Irie*, M. Kikumori, H. Kamachi, K. Tanaka, A. Murakami, R. C. Yanagita, H. Tokuda, N. Suzuki, H. Nagai, K. Suenaga and Y. Nakagawa |
K. Irie*, M. Kikumori, H. Kamachi, K. Tanaka, A. Murakami, R. C. Yanagita, H. Tokuda, N. Suzuki, H. Nagai, K. Suenaga and Y. Nakagawa |
K. Irie*, M. Kikumori, H. Kamachi, K. Tanaka, A. Murakami, R. C. Yanagita, H. Tokuda, N. Suzuki, H. Nagai, K. Suenaga and Y. Nakagawa |
Synthesis and structure-activity studies of simplified analogues of aplysiatoxin with antiproliferative activity like bryostatin-1  |
Synthesis and structure-activity studies of simplified analogues of aplysiatoxin with antiproliferative activity like bryostatin-1  |
Synthesis and structure-activity studies of simplified analogues of aplysiatoxin with antiproliferative activity like bryostatin-1  |
Pure Appl. Chem., 84, 6, 1341-1351 |
Pure Appl. Chem., 84, 6, 1341-1351 |
Pure Appl. Chem., 84, 6, 1341-1351 |
2012 |
Refereed |
English |
Research paper(scientific journal) |
Disclose to all |
S. Ueno, R. C. Yanagita, K. Murakami, A. Murakami, H. Tokuda, N. Suzuki, T. Fujiwara and K. Irie* |
S. Ueno, R. C. Yanagita, K. Murakami, A. Murakami, H. Tokuda, N. Suzuki, T. Fujiwara and K. Irie* |
S. Ueno, R. C. Yanagita, K. Murakami, A. Murakami, H. Tokuda, N. Suzuki, T. Fujiwara and K. Irie* |
Identification and biological activities of bryostatins from Japanese bryozoan  |
Identification and biological activities of bryostatins from Japanese bryozoan  |
Identification and biological activities of bryostatins from Japanese bryozoan  |
Biosci. Biotechnol. Biochem., 76, 5, 1041-1043 |
Biosci. Biotechnol. Biochem., 76, 5, 1041-1043 |
Biosci. Biotechnol. Biochem., 76, 5, 1041-1043 |
2012 |
Refereed |
English |
Research paper(scientific journal) |
Disclose to all |
K. Murakami, N. Murata, Y. Noda, K. Irie, T. Shirasawa and T. Shimizu* |
K. Murakami, N. Murata, Y. Noda, K. Irie, T. Shirasawa and T. Shimizu* |
K. Murakami, N. Murata, Y. Noda, K. Irie, T. Shirasawa and T. Shimizu* |
Stimulation of the amyloidogenic pathway by cytoplasmic superoxide radicals in an Alzheimer’s disease mouse model |
Stimulation of the amyloidogenic pathway by cytoplasmic superoxide radicals in an Alzheimer’s disease mouse model |
Stimulation of the amyloidogenic pathway by cytoplasmic superoxide radicals in an Alzheimer’s disease mouse model |
Biosci. Biotechnol. Biochem., 76, 6, 1098-1103 |
Biosci. Biotechnol. Biochem., 76, 6, 1098-1103 |
Biosci. Biotechnol. Biochem., 76, 6, 1098-1103 |
2012 |
Refereed |
English |
Research paper(scientific journal) |
Disclose to all |
Y. Shu, R. C. Yanagita, H. Tokuda, N. Suzuki and K. Irie* |
Y. Shu, R. C. Yanagita, H. Tokuda, N. Suzuki and K. Irie* |
Y. Shu, R. C. Yanagita, H. Tokuda, N. Suzuki and K. Irie* |
Synthesis of antineoplastic analogs of aplysiatoxin with various side chain structures |
Synthesis of antineoplastic analogs of aplysiatoxin with various side chain structures |
Synthesis of antineoplastic analogs of aplysiatoxin with various side chain structures |
Heterocycles, 86, 1, 281-303 |
Heterocycles, 86, 1, 281-303 |
Heterocycles, 86, 1, 281-303 |
2012 |
Refereed |
English |
Research paper(scientific journal) |
Disclose to all |
K. Irie*, R. C. Yanagita and Y. Nakagawa |
K. Irie*, R. C. Yanagita and Y. Nakagawa |
K. Irie*, R. C. Yanagita and Y. Nakagawa |
Challenges to the development of bryostatin-type anticancer drugs based on the activation mechanism of protein kinase Cδ |
Challenges to the development of bryostatin-type anticancer drugs based on the activation mechanism of protein kinase Cδ |
Challenges to the development of bryostatin-type anticancer drugs based on the activation mechanism of protein kinase Cδ |
Med. Res. Rev., 32, 3, 518-535 |
Med. Res. Rev., 32, 3, 518-535 |
Med. Res. Rev., 32, 3, 518-535 |
2012 |
Refereed |
English |
Research paper(scientific journal) |
Disclose to all |
F. Tsuji*, A. Ishihara, A. Nakagawa, M. Okada, S. Kitamura, K. Kanamaru, Y. Masuda, K. Murakami, K. Irie and Y. Sakagami |
F. Tsuji*, A. Ishihara, A. Nakagawa, M. Okada, S. Kitamura, K. Kanamaru, Y. Masuda, K. Murakami, K. Irie and Y. Sakagami |
F. Tsuji*, A. Ishihara, A. Nakagawa, M. Okada, S. Kitamura, K. Kanamaru, Y. Masuda, K. Murakami, K. Irie and Y. Sakagami |
Lack of the consensus sequence necessary for tryptophan prenylation in the ComX pheromone precursor |
Lack of the consensus sequence necessary for tryptophan prenylation in the ComX pheromone precursor |
Lack of the consensus sequence necessary for tryptophan prenylation in the ComX pheromone precursor |
Biosci. Biotechnol. Biochem., 76, 8, 1492-1496 |
Biosci. Biotechnol. Biochem., 76, 8, 1492-1496 |
Biosci. Biotechnol. Biochem., 76, 8, 1492-1496 |
2012 |
Refereed |
English |
Research paper(scientific journal) |
Disclose to all |
M. Kikumori, R. C. Yanagita, H. Tokuda, N. Suzuki, H. Nagai, K. Suenaga and K. Irie* |
M. Kikumori, R. C. Yanagita, H. Tokuda, N. Suzuki, H. Nagai, K. Suenaga and K. Irie* |
M. Kikumori, R. C. Yanagita, H. Tokuda, N. Suzuki, H. Nagai, K. Suenaga and K. Irie* |
Structure-activity studies on the spiroketal moiety of a simplified analog of debromoaplysiatoxin with antiproliferative activity |
Structure-activity studies on the spiroketal moiety of a simplified analog of debromoaplysiatoxin with antiproliferative activity |
Structure-activity studies on the spiroketal moiety of a simplified analog of debromoaplysiatoxin with antiproliferative activity |
J. Med. Chem., 55, 11, 5614-5626 |
J. Med. Chem., 55, 11, 5614-5626 |
J. Med. Chem., 55, 11, 5614-5626 |
2012 |
Refereed |
English |
Research paper(scientific journal) |
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N. Izuo, T. Kume, M. Sato, K. Murakami, K. Irie*, Y. Izumi and A. Akaike* |
N. Izuo, T. Kume, M. Sato, K. Murakami, K. Irie*, Y. Izumi and A. Akaike* |
N. Izuo, T. Kume, M. Sato, K. Murakami, K. Irie*, Y. Izumi and A. Akaike* |
Toxicity in rat primary neurons through the cellular oxidative stress induced by the turn formation at positions 22 and 23 of Aβ42 |
Toxicity in rat primary neurons through the cellular oxidative stress induced by the turn formation at positions 22 and 23 of Aβ42 |
Toxicity in rat primary neurons through the cellular oxidative stress induced by the turn formation at positions 22 and 23 of Aβ42 |
ACS Chem. Neurosci., 3, 9, 674-681 |
ACS Chem. Neurosci., 3, 9, 674-681 |
ACS Chem. Neurosci., 3, 9, 674-681 |
2012 |
Refereed |
English |
Research paper(scientific journal) |
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Y. Izumi, A. Matsumura, S. Wakita, K.-i. Akagi, H. Fukuda, T. Kume, K. Irie, H. Sugimoto, T. Hashimoto and A. Akaike* |
Y. Izumi, A. Matsumura, S. Wakita, K.-i. Akagi, H. Fukuda, T. Kume, K. Irie, H. Sugimoto, T. Hashimoto and A. Akaike* |
Y. Izumi, A. Matsumura, S. Wakita, K.-i. Akagi, H. Fukuda, T. Kume, K. Irie, H. Sugimoto, T. Hashimoto and A. Akaike* |
Isolation, identification, and biological evaluation of Nrf2-ARE activator from the leaves of green perilla (Perilla frutescencs var. crispa f. viridis)  |
Isolation, identification, and biological evaluation of Nrf2-ARE activator from the leaves of green perilla (Perilla frutescencs var. crispa f. viridis)  |
Isolation, identification, and biological evaluation of Nrf2-ARE activator from the leaves of green perilla (Perilla frutescencs var. crispa f. viridis)  |
Free Radc. Biol. Med., 53, 4, 669-679 |
Free Radc. Biol. Med., 53, 4, 669-679 |
Free Radc. Biol. Med., 53, 4, 669-679 |
2012 |
Refereed |
English |
Research paper(scientific journal) |
Disclose to all |
Y. Miyamae, M. Kurisu, K. Murakami, J. Han, H. Isoda, K. Irie and H. Shigemori* |
Y. Miyamae, M. Kurisu, K. Murakami, J. Han, H. Isoda, K. Irie and H. Shigemori* |
Y. Miyamae, M. Kurisu, K. Murakami, J. Han, H. Isoda, K. Irie and H. Shigemori* |
Protective effects of caffeoylquinic acids on the aggregation and neurotoxicity of the 42-residue amyloid β-protein |
Protective effects of caffeoylquinic acids on the aggregation and neurotoxicity of the 42-residue amyloid β-protein |
Protective effects of caffeoylquinic acids on the aggregation and neurotoxicity of the 42-residue amyloid β-protein |
Bioorg. Med. Chem., 20, 19, 5844-5849 |
Bioorg. Med. Chem., 20, 19, 5844-5849 |
Bioorg. Med. Chem., 20, 19, 5844-5849 |
2012 |
Refereed |
English |
Research paper(scientific journal) |
Disclose to all |
村上一馬,佐藤瑞穂,鈴木啓之,泉尾直孝,久米利明,赤池昭紀,永田 徹,西崎知之,富山貴美,森 啓,入江一浩* |
村上一馬,佐藤瑞穂,鈴木啓之,泉尾直孝,久米利明,赤池昭紀,永田 徹,西崎知之,富山貴美,森 啓,入江一浩* |
|
アミロイドβの「毒性コンホマー」形成とGlu22位における遺伝性変異 |
アミロイドβの「毒性コンホマー」形成とGlu22位における遺伝性変異 |
|
Dementia Japan, 26, 3, 311-318 |
Dementia Japan, 26, 3, 311-318 |
, 26, 3, 311-318 |
2012 |
|
Japanese |
Research paper(scientific journal) |
Disclose to all |
T. Doi, Y. Masuda*, K. Irie, K. Akagi, Y. Monobe, T. Imazawa and K. Takegoshi |
T. Doi, Y. Masuda*, K. Irie, K. Akagi, Y. Monobe, T. Imazawa and K. Takegoshi |
T. Doi, Y. Masuda*, K. Irie, K. Akagi, Y. Monobe, T. Imazawa and K. Takegoshi |
Solid-state NMR analysis of the β-strand orientation of the protofibrils of amyloid β-protein |
Solid-state NMR analysis of the β-strand orientation of the protofibrils of amyloid β-protein |
Solid-state NMR analysis of the β-strand orientation of the protofibrils of amyloid β-protein |
Biochem. Biophys. Res. Commun., 428, 4, 458-462 |
Biochem. Biophys. Res. Commun., 428, 4, 458-462 |
Biochem. Biophys. Res. Commun., 428, 4, 458-462 |
2012 |
Refereed |
English |
Research paper(scientific journal) |
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L. Kulic*, J. McAfoose, T. Welt, C. Tackenberg, C. Späni, F. Wirth, V. Finder, U. Konietzko, M. Giese, A. Eckert, N. Kinoshita, T. Shimizu, K. Murakami, K. Irie, S. Rasool, C. Glabe, C. Hock and R. M. Nitsch |
L. Kulic*, J. McAfoose, T. Welt, C. Tackenberg, C. Späni, F. Wirth, V. Finder, U. Konietzko, M. Giese, A. Eckert, N. Kinoshita, T. Shimizu, K. Murakami, K. Irie, S. Rasool, C. Glabe, C. Hock and R. M. Nitsch |
L. Kulic*, J. McAfoose, T. Welt, C. Tackenberg, C. Späni, F. Wirth, V. Finder, U. Konietzko, M. Giese, A. Eckert, N. Kinoshita, T. Shimizu, K. Murakami, K. Irie, S. Rasool, C. Glabe, C. Hock and R. M. Nitsch |
Early accumulation of intracellular fibrillar oligomers and late congophilic amyloid angiopathy in mice expressing the Osaka intra-Aβ APP mutation |
Early accumulation of intracellular fibrillar oligomers and late congophilic amyloid angiopathy in mice expressing the Osaka intra-Aβ APP mutation |
Early accumulation of intracellular fibrillar oligomers and late congophilic amyloid angiopathy in mice expressing the Osaka intra-Aβ APP mutation |
Transl. Psychiatry, 2, e183 |
Transl. Psychiatry, 2, e183 |
Transl. Psychiatry, 2, e183 |
2012 |
Refereed |
English |
Research paper(scientific journal) |
Disclose to all |
村上一馬,入江一浩* |
村上一馬,入江一浩* |
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Aβの毒性ターン構造を認識する抗体 |
Aβの毒性ターン構造を認識する抗体 |
|
神経内科, 77, 179-184 |
神経内科, 77, 179-184 |
, 77, 179-184 |
2012 |
|
Japanese |
Research paper(scientific journal) |
Disclose to all |
M. Takahashi*, Y. Sugiyama, K. Kawabata, Y. Takahashi, K. Irie, A. Murakami, Y. Kubo, K. Kobayashi and H. Ohigashi |
M. Takahashi*, Y. Sugiyama, K. Kawabata, Y. Takahashi, K. Irie, A. Murakami, Y. Kubo, K. Kobayashi and H. Ohigashi |
M. Takahashi*, Y. Sugiyama, K. Kawabata, Y. Takahashi, K. Irie, A. Murakami, Y. Kubo, K. Kobayashi and H. Ohigashi |
1,2-Di-O-α-linolenoyl-3-O-β-galactosyl-sn-glycerol as a superoxide generation inhibitor from Perilla frutescens var. crispa |
1,2-Di-O-α-linolenoyl-3-O-β-galactosyl-sn-glycerol as a superoxide generation inhibitor from Perilla frutescens var. crispa |
1,2-Di-O-α-linolenoyl-3-O-β-galactosyl-sn-glycerol as a superoxide generation inhibitor from Perilla frutescens var. crispa |
Biosci. Biotechnol. Biochem., 75, 11, 2240-2242 |
Biosci. Biotechnol. Biochem., 75, 11, 2240-2242 |
Biosci. Biotechnol. Biochem., 75, 11, 2240-2242 |
2011 |
Refereed |
English |
Research paper(scientific journal) |
Disclose to all |
K. Murakami*, T. Shimizu and K. Irie |
K. Murakami*, T. Shimizu and K. Irie |
K. Murakami*, T. Shimizu and K. Irie |
Formation of the 42-mer amyloid β radical and the therapeutic role of superoxide dismutase in Alzheimer's disease |
Formation of the 42-mer amyloid β radical and the therapeutic role of superoxide dismutase in Alzheimer's disease |
Formation of the 42-mer amyloid β radical and the therapeutic role of superoxide dismutase in Alzheimer's disease |
J. Amino Acids, ID 654207 |
J. Amino Acids, ID 654207 |
J. Amino Acids, ID 654207 |
2011 |
Refereed |
English |
Research paper(scientific journal) |
Disclose to all |
Y. Nakagawa, M. Kikumori, Ryo C. Yanagita, A. Murakami, H. Tokuda, H. Nagai and K. Irie* |
Y. Nakagawa, M. Kikumori, Ryo C. Yanagita, A. Murakami, H. Tokuda, H. Nagai and K. Irie* |
Y. Nakagawa, M. Kikumori, Ryo C. Yanagita, A. Murakami, H. Tokuda, H. Nagai and K. Irie* |
Synthesis and biological evaluation of the 12,12-dimethyl derivative of aplog-1, an anti-proliferative analog of tumor-promoting aplysiatoxin  |
Synthesis and biological evaluation of the 12,12-dimethyl derivative of aplog-1, an anti-proliferative analog of tumor-promoting aplysiatoxin  |
Synthesis and biological evaluation of the 12,12-dimethyl derivative of aplog-1, an anti-proliferative analog of tumor-promoting aplysiatoxin  |
Biosci. Biotechnol. Biochem., 75, 6, 1167-1173 |
Biosci. Biotechnol. Biochem., 75, 6, 1167-1173 |
Biosci. Biotechnol. Biochem., 75, 6, 1167-1173 |
2011 |
Refereed |
English |
Research paper(scientific journal) |
Disclose to all |
T. Kawamura, K. Matsubara, H. Otaka, E. Tashiro, K. Shindo, R. C. Yanagita, K. Irie and M. Imoto* |
T. Kawamura, K. Matsubara, H. Otaka, E. Tashiro, K. Shindo, R. C. Yanagita, K. Irie and M. Imoto* |
T. Kawamura, K. Matsubara, H. Otaka, E. Tashiro, K. Shindo, R. C. Yanagita, K. Irie and M. Imoto* |
Generation of 'Unnatural Natural Product' library and identification of a small molecule inhibitor of XIAP |
Generation of 'Unnatural Natural Product' library and identification of a small molecule inhibitor of XIAP |
Generation of 'Unnatural Natural Product' library and identification of a small molecule inhibitor of XIAP |
Bioorg. Med. Chem., 19, 14, 4377-4385 |
Bioorg. Med. Chem., 19, 14, 4377-4385 |
Bioorg. Med. Chem., 19, 14, 4377-4385 |
2011 |
Refereed |
English |
Research paper(scientific journal) |
Disclose to all |
K. Murakami, S. Yokoyama, N. Murata, Y. Ozawa, K. Irie, T. Shirasawa, and T. Shimizu* |
K. Murakami, S. Yokoyama, N. Murata, Y. Ozawa, K. Irie, T. Shirasawa, and T. Shimizu* |
K. Murakami, S. Yokoyama, N. Murata, Y. Ozawa, K. Irie, T. Shirasawa, and T. Shimizu* |
Insulin receptor mutation results in insulin resistance and hyperinsulinemia but does not exacerbate Alzheimer's-like phenotypes in mice |
Insulin receptor mutation results in insulin resistance and hyperinsulinemia but does not exacerbate Alzheimer's-like phenotypes in mice |
Insulin receptor mutation results in insulin resistance and hyperinsulinemia but does not exacerbate Alzheimer's-like phenotypes in mice |
Biochem. Biophys. Res. Commun., 409, 1, 34-39 |
Biochem. Biophys. Res. Commun., 409, 1, 34-39 |
Biochem. Biophys. Res. Commun., 409, 1, 34-39 |
2011 |
Refereed |
English |
Research paper(scientific journal) |
Disclose to all |
K. Murakami, S.-i. Yokoyama, N. Murata, Y. Ozawa, K. Irie, T. Shirasawa and T. Shimizu* |
K. Murakami, S.-i. Yokoyama, N. Murata, Y. Ozawa, K. Irie, T. Shirasawa and T. Shimizu* |
K. Murakami, S.-i. Yokoyama, N. Murata, Y. Ozawa, K. Irie, T. Shirasawa and T. Shimizu* |
Vitamin C restores behavioral deficits and Aβ oligomerization without affecting plaque formation in a mouse model of Alzheimer’s disease |
Vitamin C restores behavioral deficits and Aβ oligomerization without affecting plaque formation in a mouse model of Alzheimer’s disease |
Vitamin C restores behavioral deficits and Aβ oligomerization without affecting plaque formation in a mouse model of Alzheimer’s disease |
J. Alzheimers Dis., 26, 1, 7-18 |
J. Alzheimers Dis., 26, 1, 7-18 |
J. Alzheimers Dis., 26, 1, 7-18 |
2011 |
Refereed |
English |
Research paper(scientific journal) |
Disclose to all |
Y. Masuda*, M. Fukuchi, T. Yatagawa, M. Tada, K. Takeda, K. Irie, K.-i. Akagi, Y. Monobe, T. Imazawa and K. Takegoshi |
Y. Masuda*, M. Fukuchi, T. Yatagawa, M. Tada, K. Takeda, K. Irie, K.-i. Akagi, Y. Monobe, T. Imazawa and K. Takegoshi |
Y. Masuda*, M. Fukuchi, T. Yatagawa, M. Tada, K. Takeda, K. Irie, K.-i. Akagi, Y. Monobe, T. Imazawa and K. Takegoshi |
Solid-state NMR analysis of interaction sites of curcumin and 42-residue amyloid β-protein fibrils |
Solid-state NMR analysis of interaction sites of curcumin and 42-residue amyloid β-protein fibrils |
Solid-state NMR analysis of interaction sites of curcumin and 42-residue amyloid β-protein fibrils |
Bioorg. Med. Chem., 19, 20, 5967-5974 |
Bioorg. Med. Chem., 19, 20, 5967-5974 |
Bioorg. Med. Chem., 19, 20, 5967-5974 |
2011 |
Refereed |
English |
Research paper(scientific journal) |
Disclose to all |
K. Murakami, N. Murata, Y. Noda, S. Tahara, T. Kaneko, N. Kinoshita, H. Hatsuta, S. Murayama, K. J. Barnham, K. Irie, T. Shirasawa and T. Shimizu* |
K. Murakami, N. Murata, Y. Noda, S. Tahara, T. Kaneko, N. Kinoshita, H. Hatsuta, S. Murayama, K. J. Barnham, K. Irie, T. Shirasawa and T. Shimizu* |
K. Murakami, N. Murata, Y. Noda, S. Tahara, T. Kaneko, N. Kinoshita, H. Hatsuta, S. Murayama, K. J. Barnham, K. Irie, T. Shirasawa and T. Shimizu* |
SOD1 (cupper/zinc superoxide dismutase) deficiency drives amyloid β protein oligomerization and memory loss in mouse model of Alzheimer’s disease |
SOD1 (cupper/zinc superoxide dismutase) deficiency drives amyloid β protein oligomerization and memory loss in mouse model of Alzheimer’s disease |
SOD1 (cupper/zinc superoxide dismutase) deficiency drives amyloid β protein oligomerization and memory loss in mouse model of Alzheimer’s disease |
J. Biol. Chem., 286, 52, 44557-44568 |
J. Biol. Chem., 286, 52, 44557-44568 |
J. Biol. Chem., 286, 52, 44557-44568 |
2011 |
Refereed |
English |
Research paper(scientific journal) |
Disclose to all |
H. Sekiguchi, K. Irie and A. Murakami* |
H. Sekiguchi, K. Irie and A. Murakami* |
H. Sekiguchi, K. Irie and A. Murakami* |
Suppression of CD74 expression and Helicobacter pylori adhesion by auraptene targeting serum starvation-activated ERK1/2 in NCI-N87 gastric carcinoma cells |
Suppression of CD74 expression and Helicobacter pylori adhesion by auraptene targeting serum starvation-activated ERK1/2 in NCI-N87 gastric carcinoma cells |
Suppression of CD74 expression and Helicobacter pylori adhesion by auraptene targeting serum starvation-activated ERK1/2 in NCI-N87 gastric carcinoma cells |
Biosci. Biotechnol. Biochem., 74, 5, 1018-1024 |
Biosci. Biotechnol. Biochem., 74, 5, 1018-1024 |
Biosci. Biotechnol. Biochem., 74, 5, 1018-1024 |
2010 |
Refereed |
English |
Research paper(scientific journal) |
Disclose to all |
M. Yasuda, K. Irie and A. Murakami* |
M. Yasuda, K. Irie and A. Murakami* |
M. Yasuda, K. Irie and A. Murakami* |
Inhibition by genistein of the lipopolysaccharide-induced down-regulation of programmed cell death 4 in RAW 264.7 mouse macrophages |
Inhibition by genistein of the lipopolysaccharide-induced down-regulation of programmed cell death 4 in RAW 264.7 mouse macrophages |
Inhibition by genistein of the lipopolysaccharide-induced down-regulation of programmed cell death 4 in RAW 264.7 mouse macrophages |
Biosci. Biotechnol. Biochem., 74, 5, 1095-1097 |
Biosci. Biotechnol. Biochem., 74, 5, 1095-1097 |
Biosci. Biotechnol. Biochem., 74, 5, 1095-1097 |
2010 |
Refereed |
English |
Research paper(scientific journal) |
Disclose to all |
M. Yasuda, T. Schmid, D. Rübsamen, N. H. Colburn, K. Irie and A. Murakami* |
M. Yasuda, T. Schmid, D. Rübsamen, N. H. Colburn, K. Irie and A. Murakami* |
M. Yasuda, T. Schmid, D. Rübsamen, N. H. Colburn, K. Irie and A. Murakami* |
Downregulation of programmed cell death 4 by inflammatory conditions contributes to the generation of the tumor promoting microenvironment |
Downregulation of programmed cell death 4 by inflammatory conditions contributes to the generation of the tumor promoting microenvironment |
Downregulation of programmed cell death 4 by inflammatory conditions contributes to the generation of the tumor promoting microenvironment |
Mol. Carcinog., 49, 9, 837-848 |
Mol. Carcinog., 49, 9, 837-848 |
Mol. Carcinog., 49, 9, 837-848 |
2010 |
Refereed |
English |
Research paper(scientific journal) |
Disclose to all |
T. Kondo, R. Kajita, A. Miyazaki, M. Hokoyama, T. Nakamura-Miura, S. Mizuno, Y. Masuda, K. Irie, Y. Tanaka, S. Takada, T. Kakimoto* and Y. Sakagami* |
T. Kondo, R. Kajita, A. Miyazaki, M. Hokoyama, T. Nakamura-Miura, S. Mizuno, Y. Masuda, K. Irie, Y. Tanaka, S. Takada, T. Kakimoto* and Y. Sakagami* |
T. Kondo, R. Kajita, A. Miyazaki, M. Hokoyama, T. Nakamura-Miura, S. Mizuno, Y. Masuda, K. Irie, Y. Tanaka, S. Takada, T. Kakimoto* and Y. Sakagami* |
Stomatal density is controlled by a mesophyll-derived signaling molecule |
Stomatal density is controlled by a mesophyll-derived signaling molecule |
Stomatal density is controlled by a mesophyll-derived signaling molecule |
Plant Cell Physiol., 51, 1, 1-8 |
Plant Cell Physiol., 51, 1, 1-8 |
Plant Cell Physiol., 51, 1, 1-8 |
2010 |
Refereed |
English |
Research paper(scientific journal) |
Disclose to all |
M. U. Huynh, M. C. Elston, N. M. Hernandez, D. B. Ball, S. Kajiyama, K. Irie, W. H. Gerwick and D. J. Edwards* |
M. U. Huynh, M. C. Elston, N. M. Hernandez, D. B. Ball, S. Kajiyama, K. Irie, W. H. Gerwick and D. J. Edwards* |
M. U. Huynh, M. C. Elston, N. M. Hernandez, D. B. Ball, S. Kajiyama, K. Irie, W. H. Gerwick and D. J. Edwards* |
Enzymatic production of (-)-indolactam V by LtxB, a cytochrome P450 monooxygenase |
Enzymatic production of (-)-indolactam V by LtxB, a cytochrome P450 monooxygenase |
Enzymatic production of (-)-indolactam V by LtxB, a cytochrome P450 monooxygenase |
J. Nat. Prod., 73, 1, 71-74 |
J. Nat. Prod., 73, 1, 71-74 |
J. Nat. Prod., 73, 1, 71-74 |
2010 |
Refereed |
English |
Research paper(scientific journal) |
Disclose to all |
K. Murakami, Y. Horikoshi-Sakuraba, N. Murata, Y. Noda, Y. Masuda, N. Kinoshita, H. Hatsuta, S. Murayama, T. Shirasawa, T. Shimizu* and K. Irie* |
K. Murakami, Y. Horikoshi-Sakuraba, N. Murata, Y. Noda, Y. Masuda, N. Kinoshita, H. Hatsuta, S. Murayama, T. Shirasawa, T. Shimizu* and K. Irie* |
K. Murakami, Y. Horikoshi-Sakuraba, N. Murata, Y. Noda, Y. Masuda, N. Kinoshita, H. Hatsuta, S. Murayama, T. Shirasawa, T. Shimizu* and K. Irie* |
Monoclonal antibody against the turn of the 42-residue amyloid β-protein at positions 22 and 23 |
Monoclonal antibody against the turn of the 42-residue amyloid β-protein at positions 22 and 23 |
Monoclonal antibody against the turn of the 42-residue amyloid β-protein at positions 22 and 23 |
ACS Chem. Neurosci., 1, 11, 747-756 |
ACS Chem. Neurosci., 1, 11, 747-756 |
ACS Chem. Neurosci., 1, 11, 747-756 |
2010 |
Refereed |
English |
Research paper(scientific journal) |
Disclose to all |
R. C. Yanagita, H. Kamachi, K. Tanaka, A. Murakami, Y. Nakagawa, H. Tokuda, H. Nagai and K. Irie* |
R. C. Yanagita, H. Kamachi, K. Tanaka, A. Murakami, Y. Nakagawa, H. Tokuda, H. Nagai and K. Irie* |
R. C. Yanagita, H. Kamachi, K. Tanaka, A. Murakami, Y. Nakagawa, H. Tokuda, H. Nagai and K. Irie* |
Role of the phenolic hydroxyl group in the biological activities of simplified analogue of aplysiatoxin with antiproliferative activity  |
Role of the phenolic hydroxyl group in the biological activities of simplified analogue of aplysiatoxin with antiproliferative activity  |
Role of the phenolic hydroxyl group in the biological activities of simplified analogue of aplysiatoxin with antiproliferative activity  |
Bioorg. Med. Chem. Lett., 20, 20, 6064-6066 |
Bioorg. Med. Chem. Lett., 20, 20, 6064-6066 |
Bioorg. Med. Chem. Lett., 20, 20, 6064-6066 |
2010 |
Refereed |
English |
Research paper(scientific journal) |
Disclose to all |
N. Murata, K. Murakami, Y. Ozawa, N. Kinoshita, K. Irie, T. Shirasawa and T. Shimizu* |
N. Murata, K. Murakami, Y. Ozawa, N. Kinoshita, K. Irie, T. Shirasawa and T. Shimizu* |
N. Murata, K. Murakami, Y. Ozawa, N. Kinoshita, K. Irie, T. Shirasawa and T. Shimizu* |
Silymarin attenuated the amyloid βplaque burden and improved behavioral abnormalities in an Alzheimer's disease mouse model |
Silymarin attenuated the amyloid βplaque burden and improved behavioral abnormalities in an Alzheimer's disease mouse model |
Silymarin attenuated the amyloid βplaque burden and improved behavioral abnormalities in an Alzheimer's disease mouse model |
Biosci. Biotechnol. Biochem., 74, 11, 2299-2306 |
Biosci. Biotechnol. Biochem., 74, 11, 2299-2306 |
Biosci. Biotechnol. Biochem., 74, 11, 2299-2306 |
2010 |
Refereed |
English |
Research paper(scientific journal) |
Disclose to all |
T. Suzuki, K. Murakami, N. Izuo, T. Kume, A. Akaike, T. Nagata, T. Nishizaki, T. Tomiyama, H. Takuma, H. Mori and K. Irie* |
T. Suzuki, K. Murakami, N. Izuo, T. Kume, A. Akaike, T. Nagata, T. Nishizaki, T. Tomiyama, H. Takuma, H. Mori and K. Irie* |
T. Suzuki, K. Murakami, N. Izuo, T. Kume, A. Akaike, T. Nagata, T. Nishizaki, T. Tomiyama, H. Takuma, H. Mori and K. Irie* |
E22Δ mutation in amyloid β-protein promotes β-sheet transformation, radical production, and synaptotoxicity, but not neurotoxicity |
E22Δ mutation in amyloid β-protein promotes β-sheet transformation, radical production, and synaptotoxicity, but not neurotoxicity |
E22Δ mutation in amyloid β-protein promotes β-sheet transformation, radical production, and synaptotoxicity, but not neurotoxicity |
Int. J. Alzheimers Dis., ID 431320 |
Int. J. Alzheimers Dis., ID 431320 |
Int. J. Alzheimers Dis., ID 431320 |
2010 |
Refereed |
English |
Research paper(scientific journal) |
Disclose to all |
増田 裕一*, 入江 一浩 |
増田 裕一*, 入江 一浩 |
|
ポリフェノールによるアルツハイマー病予防の可能性 |
ポリフェノールによるアルツハイマー病予防の可能性 |
|
FFIジャーナル, 215, 1, 53-59 |
FFIジャーナル, 215, 1, 53-59 |
, 215, 1, 53-59 |
2010 |
Refereed |
Japanese |
Research paper(scientific journal) |
Disclose to all |
K. Murakami*, Y. Masuda, T. Shirasawa, T. Shimizu and K. Irie |
K. Murakami*, Y. Masuda, T. Shirasawa, T. Shimizu and K. Irie |
K. Murakami*, Y. Masuda, T. Shirasawa, T. Shimizu and K. Irie |
The turn formation at positions 22 and 23 in the 42-mer amyloid β peptide: the emerging role in the pathogenesis of Alzheimer's disease |
The turn formation at positions 22 and 23 in the 42-mer amyloid β peptide: the emerging role in the pathogenesis of Alzheimer's disease |
The turn formation at positions 22 and 23 in the 42-mer amyloid β peptide: the emerging role in the pathogenesis of Alzheimer's disease |
Geriat. Geront. Int., 10, Sup1, 169-179 |
Geriat. Geront. Int., 10, Sup1, 169-179 |
Geriat. Geront. Int., 10, Sup1, 169-179 |
2010 |
Refereed |
English |
Research paper(scientific journal) |
Disclose to all |
Y. Masuda, S. Uemura, R. Ohashi, A. Nakanishi, K. Takegoshi, T. Shimizu, T. Shirasawa and K. Irie* |
Y. Masuda, S. Uemura, R. Ohashi, A. Nakanishi, K. Takegoshi, T. Shimizu, T. Shirasawa and K. Irie* |
Y. Masuda, S. Uemura, R. Ohashi, A. Nakanishi, K. Takegoshi, T. Shimizu, T. Shirasawa and K. Irie* |
Identification of physiological and toxic conformations in Abeta42 aggregates |
Identification of physiological and toxic conformations in Abeta42 aggregates |
Identification of physiological and toxic conformations in Abeta42 aggregates |
ChemBioChem, 10, 2, 287-295 |
ChemBioChem, 10, 2, 287-295 |
ChemBioChem, 10, 2, 287-295 |
2009 |
Refereed |
English |
Research paper(scientific journal) |
Disclose to all |
Y. Nakagawa, R. C. Yanagita, N. Hamada, A. Murakami, H. Takahashi, N. Saito, H. Nagai and K. Irie* |
Y. Nakagawa, R. C. Yanagita, N. Hamada, A. Murakami, H. Takahashi, N. Saito, H. Nagai and K. Irie* |
Y. Nakagawa, R. C. Yanagita, N. Hamada, A. Murakami, H. Takahashi, N. Saito, H. Nagai and K. Irie* |
A simple analogue of tumor-promoting aplysiatoxin is an antineoplastic agent rather than a tumor promoter: development of a synthetically accessible protein kinase C activator with bryostatin-like activity |
A simple analogue of tumor-promoting aplysiatoxin is an antineoplastic agent rather than a tumor promoter: development of a synthetically accessible protein kinase C activator with bryostatin-like activity |
A simple analogue of tumor-promoting aplysiatoxin is an antineoplastic agent rather than a tumor promoter: development of a synthetically accessible protein kinase C activator with bryostatin-like activity |
J. Am. Chem. Soc., 131, 22, 7573-7579 |
J. Am. Chem. Soc., 131, 22, 7573-7579 |
J. Am. Chem. Soc., 131, 22, 7573-7579 |
2009 |
Refereed |
English |
Research paper(scientific journal) |
Disclose to all |
K. Ohnishi, K. Irie and A. Murakami* |
K. Ohnishi, K. Irie and A. Murakami* |
K. Ohnishi, K. Irie and A. Murakami* |
In vitro covalent binding proteins of zerumbone, a chemopreventive food factor |
In vitro covalent binding proteins of zerumbone, a chemopreventive food factorK. Ohnishi, K. Irie and A. Murakami* |
In vitro covalent binding proteins of zerumbone, a chemopreventive food factor |
Biosci. Biotechnol. Biochem., 73, 8, 1905-1907 |
Biosci. Biotechnol. Biochem., 73, 8, 1905-1907 |
Biosci. Biotechnol. Biochem., 73, 8, 1905-1907 |
2009 |
Refereed |
English |
Research paper(scientific journal) |
Disclose to all |
K. Murakami, M. Uno, Y. Masuda, T. Shimizu, T. Shirasawa and K. Irie* |
K. Murakami, M. Uno, Y. Masuda, T. Shimizu, T. Shirasawa and K. Irie* |
K. Murakami, M. Uno, Y. Masuda, T. Shimizu, T. Shirasawa and K. Irie* |
Isomerization and/or racemization at Asp-23 of Abeta42 do not increase its aggregative ability and neurotoxicity in vitro |
Isomerization and/or racemization at Asp-23 of Abeta42 do not increase its aggregative ability and neurotoxicity in vitro |
Isomerization and/or racemization at Asp-23 of Abeta42 do not increase its aggregative ability and neurotoxicity in vitro |
Biochem. Biophys. Res. Commun., 366, 3, 745-751 |
Biochem. Biophys. Res. Commun., 366, 3, 745-751 |
Biochem. Biophys. Res. Commun., 366, 3, 745-751 |
2008 |
Refereed |
English |
Research paper(scientific journal) |
Disclose to all |
R. C. Yanagita, Y. Nakagawa, N. Yamanaka, K. Kashiwagi, N. Saito and K. Irie* |
R. C. Yanagita, Y. Nakagawa, N. Yamanaka, K. Kashiwagi, N. Saito and K. Irie* |
R. C. Yanagita, Y. Nakagawa, N. Yamanaka, K. Kashiwagi, N. Saito and K. Irie* |
Synthesis, conformational analysis, and biological evaluation of 1-hexylindolactam-V10 as a selective activator for novel protein kinase C isozymes |
Synthesis, conformational analysis, and biological evaluation of 1-hexylindolactam-V10 as a selective activator for novel protein kinase C isozymes |
Synthesis, conformational analysis, and biological evaluation of 1-hexylindolactam-V10 as a selective activator for novel protein kinase C isozymes |
J. Med. Chem., 51, 1, 46-56 |
J. Med. Chem., 51, 1, 46-56 |
J. Med. Chem., 51, 1, 46-56 |
2008 |
Refereed |
English |
Research paper(scientific journal) |
Disclose to all |
T. Sugimoto, K. Itagaki and K. Irie* |
T. Sugimoto, K. Itagaki and K. Irie* |
T. Sugimoto, K. Itagaki and K. Irie* |
Design and physicochemical properties of new fluorescent ligands of protein kinase C isozymes focused on CH/π interaction |
Design and physicochemical properties of new fluorescent ligands of protein kinase C isozymes focused on CH/π interaction |
Design and physicochemical properties of new fluorescent ligands of protein kinase C isozymes focused on CH/π interaction |
Bioorg. Med. Chem., 16, 2, 650-657 |
Bioorg. Med. Chem., 16, 2, 650-657 |
Bioorg. Med. Chem., 16, 2, 650-657 |
2008 |
Refereed |
English |
Research paper(scientific journal) |
Disclose to all |
Y. Masuda, S. Uemura, A. Nakanishi, R. Ohashi, K. Takegoshi, T. Shimizu, T. Shirasawa and K. Irie* |
Y. Masuda, S. Uemura, A. Nakanishi, R. Ohashi, K. Takegoshi, T. Shimizu, T. Shirasawa and K. Irie* |
Y. Masuda, S. Uemura, A. Nakanishi, R. Ohashi, K. Takegoshi, T. Shimizu, T. Shirasawa and K. Irie* |
Verification of the C-terminal intramolecular beta-sheet in Abeta42 aggregates using solid-state NMR: Implications for potent neurotoxicity through the formation of radicals |
Verification of the C-terminal intramolecular beta-sheet in Abeta42 aggregates using solid-state NMR: Implications for potent neurotoxicity through the formation of radicals |
Verification of the C-terminal intramolecular beta-sheet in Abeta42 aggregates using solid-state NMR: Implications for potent neurotoxicity through the formation of radicals |
Bioorg. Med. Chem. Lett., 18, 11, 3206-3210 |
Bioorg. Med. Chem. Lett., 18, 11, 3206-3210 |
Bioorg. Med. Chem. Lett., 18, 11, 3206-3210 |
2008 |
Refereed |
English |
Research paper(scientific journal) |
Disclose to all |
Y. Masuda, A. Nakanishi, R. Ohashi, K. Takegoshi, T. Shimizu, T. Shirasawa and K. Irie* |
Y. Masuda, A. Nakanishi, R. Ohashi, K. Takegoshi, T. Shimizu, T. Shirasawa and K. Irie* |
Y. Masuda, A. Nakanishi, R. Ohashi, K. Takegoshi, T. Shimizu, T. Shirasawa and K. Irie* |
Verification of the intermolecular parallel beta-sheet in E22K-Abeta42 aggregates by solid-state NMR using rotational resonance: implications for the supramolecular arrangement of the toxic conformer of Abeta42 |
Verification of the intermolecular parallel beta-sheet in E22K-Abeta42 aggregates by solid-state NMR using rotational resonance: implications for the supramolecular arrangement of the toxic conformer of Abeta42 |
Verification of the intermolecular parallel beta-sheet in E22K-Abeta42 aggregates by solid-state NMR using rotational resonance: implications for the supramolecular arrangement of the toxic conformer of Abeta42 |
Biosci. Biotechnol. Biochem., 72, 8, 2170-2175 |
Biosci. Biotechnol. Biochem., 72, 8, 2170-2175 |
Biosci. Biotechnol. Biochem., 72, 8, 2170-2175 |
2008 |
Refereed |
English |
Research paper(scientific journal) |
Disclose to all |
村上 一馬*, 清水 孝彦, 白澤 卓二, 入江 一浩 |
村上 一馬*, 清水 孝彦, 白澤 卓二, 入江 一浩 |
|
βアミロイドの毒性コンホメーション |
βアミロイドの毒性コンホメーション |
|
化学と生物, 46, 6, 431-434 |
化学と生物, 46, 6, 431-434 |
, 46, 6, 431-434 |
2008 |
Refereed |
Japanese |
Research paper(scientific journal) |
Disclose to all |
入江 一浩*, 増田 裕一 |
入江 一浩*, 増田 裕一 |
|
アミロイドβ (Aβ42) の毒性コンホメーションの提唱 |
アミロイドβ (Aβ42) の毒性コンホメーションの提唱 |
|
基礎老化研究, 32, 3, 25-29 |
基礎老化研究, 32, 3, 25-29 |
, 32, 3, 25-29 |
2008 |
Refereed |
Japanese |
Research paper(scientific journal) |
Disclose to all |
R. C. Yanagita, K. Torii, Y. Nakagawa and K. Irie* |
R. C. Yanagita, K. Torii, Y. Nakagawa and K. Irie* |
R. C. Yanagita, K. Torii, Y. Nakagawa and K. Irie* |
Binding selectivity of 1- or 12-substituted indolactam derivatives for protein kinase C isozymes |
Binding selectivity of 1- or 12-substituted indolactam derivatives for protein kinase C isozymes |
Binding selectivity of 1- or 12-substituted indolactam derivatives for protein kinase C isozymes |
Heterocycles, 73, 289-302 |
Heterocycles, 73, 289-302 |
Heterocycles, 73, 289-302 |
2007 |
Refereed |
English |
Research paper(scientific journal) |
Disclose to all |
K. Murakami, H. Hara, Y. Masuda, H. Ohigashi and K. irie* |
K. Murakami, H. Hara, Y. Masuda, H. Ohigashi and K. irie* |
K. Murakami, H. Hara, Y. Masuda, H. Ohigashi and K. irie* |
Distance measurement between Tyr10 and Met35 in amyloid beta by site-directed spin-labeling ESR spectroscopy: implications for the stronger neurotoxicity of Abeta42 than Abeta40 |
Distance measurement between Tyr10 and Met35 in amyloid beta by site-directed spin-labeling ESR spectroscopy: implications for the stronger neurotoxicity of Abeta42 than Abeta40 |
Distance measurement between Tyr10 and Met35 in amyloid beta by site-directed spin-labeling ESR spectroscopy: implications for the stronger neurotoxicity of Abeta42 than Abeta40 |
ChemBioChem, 8, 18, 2308-2314 |
ChemBioChem, 8, 18, 2308-2314 |
ChemBioChem, 8, 18, 2308-2314 |
2007 |
Refereed |
English |
Research paper(scientific journal) |
Disclose to all |
K. Irie*, K. Murakami, Y. Masuda, A. Morimoto, H. Ohigashi, H. Hara, R. Ohashi, K. Takegoshi, H. Fukuda, M. Nagao, T. Shimizu and T. Shirasawa |
K. Irie*, K. Murakami, Y. Masuda, A. Morimoto, H. Ohigashi, H. Hara, R. Ohashi, K. Takegoshi, H. Fukuda, M. Nagao, T. Shimizu and T. Shirasawa |
K. Irie*, K. Murakami, Y. Masuda, A. Morimoto, H. Ohigashi, H. Hara, R. Ohashi, K. Takegoshi, H. Fukuda, M. Nagao, T. Shimizu and T. Shirasawa |
The toxic conformation of the 42-residue amyloid β peptide and Its relevance to oxidative stress in alzheimer's disease |
The toxic conformation of the 42-residue amyloid β peptide and Its relevance to oxidative stress in alzheimer's disease |
The toxic conformation of the 42-residue amyloid β peptide and Its relevance to oxidative stress in alzheimer's disease |
Mini-Rev. Med. Chem., 7, 10, 1001-1008 |
Mini-Rev. Med. Chem., 7, 10, 1001-1008 |
Mini-Rev. Med. Chem., 7, 10, 1001-1008 |
2007 |
Refereed |
English |
Research paper(scientific journal) |
Disclose to all |
Y. Nakagawa, K. Irie*, R. C. Yanagita, H. Ohigashi, K. Tsuda, K. Kashiwagi and N. Saito |
Y. Nakagawa, K. Irie*, R. C. Yanagita, H. Ohigashi, K. Tsuda, K. Kashiwagi and N. Saito |
Y. Nakagawa, K. Irie*, R. C. Yanagita, H. Ohigashi, K. Tsuda, K. Kashiwagi and N. Saito |
Design and synthesis of 8-octyl-benzolactam-V9, a selective activator for protein kinase C epsilon and eta |
Design and synthesis of 8-octyl-benzolactam-V9, a selective activator for protein kinase C epsilon and eta |
Design and synthesis of 8-octyl-benzolactam-V9, a selective activator for protein kinase C epsilon and eta |
J. Med. Chem., 49, 9, 2681-2688 |
J. Med. Chem., 49, 9, 2681-2688 |
J. Med. Chem., 49, 9, 2681-2688 |
2006 |
Refereed |
English |
Research paper(scientific journal) |
Disclose to all |
入江 一浩 |
入江 一浩 |
|
CH/π相互作用を利用した薬剤開発 |
CH/π相互作用を利用した薬剤開発 |
|
ファルマシア, 42, 5, 427-430 |
ファルマシア, 42, 5, 427-430 |
, 42, 5, 427-430 |
2006 |
Refereed |
Japanese |
Research paper(scientific journal) |
Disclose to all |
Y. Nakagawa, K. Irie*, R. C. Yanagita, H. Ohigashi and K. Tsuda |
Y. Nakagawa, K. Irie*, R. C. Yanagita, H. Ohigashi and K. Tsuda |
Y. Nakagawa, K. Irie*, R. C. Yanagita, H. Ohigashi and K. Tsuda |
Indolactam-V is involved in the CH/π interaction with Pro-11 of the PKCdelta C1B domain: application for the structural optimization of the PKCdelta ligand |
Indolactam-V is involved in the CH/π interaction with Pro-11 of the PKCdelta C1B domain: application for the structural optimization of the PKCdelta ligand |
Indolactam-V is involved in the CH/π interaction with Pro-11 of the PKCdelta C1B domain: application for the structural optimization of the PKCdelta ligand |
J. Am. Chem. Soc., 127, 16, 5746-5747 |
J. Am. Chem. Soc., 127, 16, 5746-5747 |
J. Am. Chem. Soc., 127, 16, 5746-5747 |
2005 |
Refereed |
English |
Research paper(scientific journal) |
Disclose to all |
K. Murakami, K. Irie*, H. Ohigashi, H. Hara, M. Nagao, T. Shimizu and T. Shirasawa |
K. Murakami, K. Irie*, H. Ohigashi, H. Hara, M. Nagao, T. Shimizu and T. Shirasawa |
K. Murakami, K. Irie*, H. Ohigashi, H. Hara, M. Nagao, T. Shimizu and T. Shirasawa |
Formation and stabilization model of the 42-mer Abeta radical: implications for the long-lasting oxidative stress in Alzheimer's disease |
Formation and stabilization model of the 42-mer Abeta radical: implications for the long-lasting oxidative stress in Alzheimer's disease |
Formation and stabilization model of the 42-mer Abeta radical: implications for the long-lasting oxidative stress in Alzheimer's disease |
J. Am. Chem. Soc., 127, 43, 15168-15174 |
J. Am. Chem. Soc., 127, 43, 15168-15174 |
J. Am. Chem. Soc., 127, 43, 15168-15174 |
2005 |
Refereed |
English |
Research paper(scientific journal) |
Disclose to all |
M. Nagao*, T.-C. Wen, M. Okamoto, K. Irie, T. Takaku and M. Sakanaka |
M. Nagao*, T.-C. Wen, M. Okamoto, K. Irie, T. Takaku and M. Sakanaka |
M. Nagao*, T.-C. Wen, M. Okamoto, K. Irie, T. Takaku and M. Sakanaka |
In vivo neuroprotective activity of epopeptide AB against ischemic damage |
In vivo neuroprotective activity of epopeptide AB against ischemic damage |
In vivo neuroprotective activity of epopeptide AB against ischemic damage |
Cytotechnol., 47, 1/3, 139-144 |
Cytotechnol., 47, 1/3, 139-144 |
Cytotechnol., 47, 1/3, 139-144 |
2005 |
Refereed |
English |
Research paper(scientific journal) |
Disclose to all |
Y. Masuda, K. Irie*, K. Murakami, H. Ohigashi, R. Ohashi, K. Takegoshi, T. Shimizu and T. Shirasawa |
Y. Masuda, K. Irie*, K. Murakami, H. Ohigashi, R. Ohashi, K. Takegoshi, T. Shimizu and T. Shirasawa |
Y. Masuda, K. Irie*, K. Murakami, H. Ohigashi, R. Ohashi, K. Takegoshi, T. Shimizu and T. Shirasawa |
Verification of the turn at positions 22 and 23 of the beta-amyloid fibrils with Italian mutation using solid-state NMR |
Verification of the turn at positions 22 and 23 of the beta-amyloid fibrils with Italian mutation using solid-state NMR |
Verification of the turn at positions 22 and 23 of the beta-amyloid fibrils with Italian mutation using solid-state NMR |
Bioorg. Med. Chem., 13, 24, 6803-6809 |
Bioorg. Med. Chem., 13, 24, 6803-6809 |
Bioorg. Med. Chem., 13, 24, 6803-6809 |
2005 |
Refereed |
English |
Research paper(scientific journal) |
Disclose to all |
K. Irie*, K. Murakami, Y. Masuda, A. Morimoto, H. Ohigashi, R. Ohashi, K. Takegoshi, M. Nagao, T. Shimizu and T. Shirasawa |
K. Irie*, K. Murakami, Y. Masuda, A. Morimoto, H. Ohigashi, R. Ohashi, K. Takegoshi, M. Nagao, T. Shimizu and T. Shirasawa |
K. Irie*, K. Murakami, Y. Masuda, A. Morimoto, H. Ohigashi, R. Ohashi, K. Takegoshi, M. Nagao, T. Shimizu and T. Shirasawa |
Structure of beta-amyloid fibrils and its relavence to their neurotoxicity:implications for the pathogenesis of Alzheimer's disease |
Structure of beta-amyloid fibrils and its relavence to their neurotoxicity:implications for the pathogenesis of Alzheimer's disease |
Structure of beta-amyloid fibrils and its relavence to their neurotoxicity:implications for the pathogenesis of Alzheimer's disease |
J. Biosci. Bioeng., 99, 5, 437-447 |
J. Biosci. Bioeng., 99, 5, 437-447 |
J. Biosci. Bioeng., 99, 5, 437-447 |
2005 |
Refereed |
English |
Research paper(scientific journal) |
Disclose to all |
K. Irie*, Y. Nakagawa and H. Ohigashi |
K. Irie*, Y. Nakagawa and H. Ohigashi |
K. Irie*, Y. Nakagawa and H. Ohigashi |
Toward the development of new medicinal leads with selectivity for protein kinase C isozymes |
Toward the development of new medicinal leads with selectivity for protein kinase C isozymes |
Toward the development of new medicinal leads with selectivity for protein kinase C isozymes |
Chem. Rec., 5, 4, 185-195 |
Chem. Rec., 5, 4, 185-195 |
Chem. Rec., 5, 4, 185-195 |
2005 |
Refereed |
English |
Research paper(scientific journal) |
Disclose to all |
Y. Nakagawa, K. Irie*, Y. Komiya, H. Ohigashi and K. Tsuda |
Y. Nakagawa, K. Irie*, Y. Komiya, H. Ohigashi and K. Tsuda |
Y. Nakagawa, K. Irie*, Y. Komiya, H. Ohigashi and K. Tsuda |
Synthesis, conformation and PKC isozyme surrogate binding of indolinelactam-Vs, new conformationally restricted analogues of (-)-indolactam-V |
Synthesis, conformation and PKC isozyme surrogate binding of indolinelactam-Vs, new conformationally restricted analogues of (-)-indolactam-V |
Synthesis, conformation and PKC isozyme surrogate binding of indolinelactam-Vs, new conformationally restricted analogues of (-)-indolactam-V |
Tetrahedron, 60/33, 7077-7084 |
Tetrahedron, 60/33, 7077-7084 |
Tetrahedron, 60/33, 7077-7084 |
2004 |
Refereed |
English |
Research paper(scientific journal) |
Disclose to all |
K. Irie*, A. Masuda, M. Shindo, Y. Nakagawa and H. Ohigashi |
K. Irie*, A. Masuda, M. Shindo, Y. Nakagawa and H. Ohigashi |
K. Irie*, A. Masuda, M. Shindo, Y. Nakagawa and H. Ohigashi |
Tumor promoter binding of the protein kinase C C1 homology domain peptides of RasGRPs, chimaerins, and Unc13s |
Tumor promoter binding of the protein kinase C C1 homology domain peptides of RasGRPs, chimaerins, and Unc13s |
Tumor promoter binding of the protein kinase C C1 homology domain peptides of RasGRPs, chimaerins, and Unc13s |
Bioorg. Med. Chem., 12/17, 4575-4583 |
Bioorg. Med. Chem., 12/17, 4575-4583 |
Bioorg. Med. Chem., 12/17, 4575-4583 |
2004 |
Refereed |
English |
Research paper(scientific journal) |
Disclose to all |
A. Morimoto, K. Irie*, K. Murakami, Y. Masuda, H. Ohigashi, M. Nagao, H. Fukuda, T. Shimizu and T. Shirasawa |
A. Morimoto, K. Irie*, K. Murakami, Y. Masuda, H. Ohigashi, M. Nagao, H. Fukuda, T. Shimizu and T. Shirasawa |
A. Morimoto, K. Irie*, K. Murakami, Y. Masuda, H. Ohigashi, M. Nagao, H. Fukuda, T. Shimizu and T. Shirasawa |
Analysis of the secondary structure of beta-amyloid (Abeta42) fibrils by systematic proline replacement |
Analysis of the secondary structure of beta-amyloid (Abeta42) fibrils by systematic proline replacement |
Analysis of the secondary structure of beta-amyloid (Abeta42) fibrils by systematic proline replacement |
J. Biol. Chem., 279/50, 52781-52788 |
J. Biol. Chem., 279/50, 52781-52788 |
J. Biol. Chem., 279/50, 52781-52788 |
2004 |
Refereed |
English |
Research paper(scientific journal) |
Disclose to all |
入江一浩*、大東 肇 |
入江一浩*、大東 肇 |
|
ペプチド合成によるホルボールエステル受容体の機能解析 |
ペプチド合成によるホルボールエステル受容体の機能解析 |
|
化学と生物, 42/1, 54-62 |
化学と生物, 42/1, 54-62 |
|
2004 |
Refereed |
Japanese |
Research paper(scientific journal) |
Disclose to all |
K. Irie*, Y. Nakagawa and H. Ohigashi |
K. Irie*, Y. Nakagawa and H. Ohigashi |
K. Irie*, Y. Nakagawa and H. Ohigashi |
Indolactam and benzolactam compounds as new medicinal leads with binding selectivity for C1 domains of protein kinase C isozymes |
Indolactam and benzolactam compounds as new medicinal leads with binding selectivity for C1 domains of protein kinase C isozymes |
Indolactam and benzolactam compounds as new medicinal leads with binding selectivity for C1 domains of protein kinase C isozymes |
Curr. Pharm. Design, 10, 12, 1371-1385 |
Curr. Pharm. Design, 10, 12, 1371-1385 |
Curr. Pharm. Design, 10, 12, 1371-1385 |
2004 |
Refereed |
English |
Research paper(scientific journal) |
Disclose to all |
M. Shindo, K. Irie*, A. Masuda, H. Ohigashi, Y. Shirai, K. Miyasaki and N. Saito |
M. Shindo, K. Irie*, A. Masuda, H. Ohigashi, Y. Shirai, K. Miyasaki and N. Saito |
M. Shindo, K. Irie*, A. Masuda, H. Ohigashi, Y. Shirai, K. Miyasaki and N. Saito |
Synthesis and phorbol ester binding of the cysteine-rich domains of diacylglycerol kinase (DGK) isozymes; DGKgamma and DGKbeta are new targets of tumor-promoting phorbol esters |
Synthesis and phorbol ester binding of the cysteine-rich domains of diacylglycerol kinase (DGK) isozymes; DGKgamma and DGKbeta are new targets of tumor-promoting phorbol esters |
Synthesis and phorbol ester binding of the cysteine-rich domains of diacylglycerol kinase (DGK) isozymes; DGKgamma and DGKbeta are new targets of tumor-promoting phorbol esters |
J. Biol. Chem., 278/20, 18448-18454 |
J. Biol. Chem., 278/20, 18448-18454 |
J. Biol. Chem., 278/20, 18448-18454 |
2003 |
Refereed |
English |
Research paper(scientific journal) |
Disclose to all |
Y. Nakagawa, K. Irie*, N. Yamanaka, H. Ohigashi and K. Tsuda |
Y. Nakagawa, K. Irie*, N. Yamanaka, H. Ohigashi and K. Tsuda |
Y. Nakagawa, K. Irie*, N. Yamanaka, H. Ohigashi and K. Tsuda |
Synthesis and binding selectivity of 7- and 15-decylbenzolactone-V8 for the C1 domains of protein kinase C isozymes |
Synthesis and binding selectivity of 7- and 15-decylbenzolactone-V8 for the C1 domains of protein kinase C isozymes |
Synthesis and binding selectivity of 7- and 15-decylbenzolactone-V8 for the C1 domains of protein kinase C isozymes |
Bioorg. Med. Chem. Lett., 13/18, 3015-3019 |
Bioorg. Med. Chem. Lett., 13/18, 3015-3019 |
Bioorg. Med. Chem. Lett., 13/18, 3015-3019 |
2003 |
Refereed |
English |
Research paper(scientific journal) |
Disclose to all |
K. Murakami, K. Irie*, A. Morimoto, H. Ohigashi, M. Shindo, M. Nagao, T. Shimizu and T. Shirasawa |
K. Murakami, K. Irie*, A. Morimoto, H. Ohigashi, M. Shindo, M. Nagao, T. Shimizu and T. Shirasawa |
K. Murakami, K. Irie*, A. Morimoto, H. Ohigashi, M. Shindo, M. Nagao, T. Shimizu and T. Shirasawa |
Neurotoxicity and physicochemical properties of Abeta mutant peptides from cerebral amyloid angiopathy: implication for the pathogenesis of cerebral amyloid angiopathy and Alzheimer's disease |
Neurotoxicity and physicochemical properties of Abeta mutant peptides from cerebral amyloid angiopathy: implication for the pathogenesis of cerebral amyloid angiopathy and Alzheimer's disease |
Neurotoxicity and physicochemical properties of Abeta mutant peptides from cerebral amyloid angiopathy: implication for the pathogenesis of cerebral amyloid angiopathy and Alzheimer's disease |
J. Biol. Chem., 278/46, 46179-46187 |
J. Biol. Chem., 278/46, 46179-46187 |
J. Biol. Chem., 278/46, 46179-46187 |
2003 |
Refereed |
English |
Research paper(scientific journal) |
Disclose to all |
M. Shindo, K. Irie*, H. Fukuda and H. Ohigashi |
M. Shindo, K. Irie*, H. Fukuda and H. Ohigashi |
M. Shindo, K. Irie*, H. Fukuda and H. Ohigashi |
Analysis of the non-covalent interaction between metal ions and the cysteine-rich domain of protein kinase C eta by electrospray ionization mass spectrometry |
Analysis of the non-covalent interaction between metal ions and the cysteine-rich domain of protein kinase C eta by electrospray ionization mass spectrometry |
Analysis of the non-covalent interaction between metal ions and the cysteine-rich domain of protein kinase C eta by electrospray ionization mass spectrometry |
Bioorg. Med. Chem., 11/23, 5075-5082 |
Bioorg. Med. Chem., 11/23, 5075-5082 |
Bioorg. Med. Chem., 11/23, 5075-5082 |
2003 |
Refereed |
English |
Research paper(scientific journal) |
Disclose to all |
Y. Nakagawa, K. Irie*, A. Masuda and H. Ohigashi |
Y. Nakagawa, K. Irie*, A. Masuda and H. Ohigashi |
Y. Nakagawa, K. Irie*, A. Masuda and H. Ohigashi |
Synthesis, conformation and PKC isozyme surrogate binding of new lactone analogues of benzolactam-V8s |
Synthesis, conformation and PKC isozyme surrogate binding of new lactone analogues of benzolactam-V8s |
Synthesis, conformation and PKC isozyme surrogate binding of new lactone analogues of benzolactam-V8s |
Tetrahedron, 58/6, 2101-2115 |
Tetrahedron, 58/6, 2101-2115 |
Tetrahedron, 58/6, 2101-2115 |
2002 |
Refereed |
English |
Research paper(scientific journal) |
Disclose to all |
K. Murakami, K. Irie*, A. Morimoto, H. Ohigashi, M. Shindo, M. Nagao, T. Shimizu and T. Shirasawa |
K. Murakami, K. Irie*, A. Morimoto, H. Ohigashi, M. Shindo, M. Nagao, T. Shimizu and T. Shirasawa |
K. Murakami, K. Irie*, A. Morimoto, H. Ohigashi, M. Shindo, M. Nagao, T. Shimizu and T. Shirasawa |
Synthesis, aggregation, neurotoxicity, and secondary structure of various Abeta1-42 mutants of familial Alzheimer's disease at positions 21-23 |
Synthesis, aggregation, neurotoxicity, and secondary structure of various Abeta1-42 mutants of familial Alzheimer's disease at positions 21-23 |
Synthesis, aggregation, neurotoxicity, and secondary structure of various Abeta1-42 mutants of familial Alzheimer's disease at positions 21-23 |
Biochem. Biophys. Res. Commun., 294/1, 5-10 |
Biochem. Biophys. Res. Commun., 294/1, 5-10 |
Biochem. Biophys. Res. Commun., 294/1, 5-10 |
2002 |
Refereed |
English |
Research paper(scientific journal) |
Disclose to all |
A. Masuda, K. Irie*, Y. Nakagawa and H. Ohigashi |
A. Masuda, K. Irie*, Y. Nakagawa and H. Ohigashi |
A. Masuda, K. Irie*, Y. Nakagawa and H. Ohigashi |
Binding selectivity of conformationally restricted analogues of (-)-indolactam-V to the C1 domains of protein kinase C isozymes |
Binding selectivity of conformationally restricted analogues of (-)-indolactam-V to the C1 domains of protein kinase C isozymes |
Binding selectivity of conformationally restricted analogues of (-)-indolactam-V to the C1 domains of protein kinase C isozymes |
Biosci. Biotechnol. Biochem., 66/7, 1615-1617 |
Biosci. Biotechnol. Biochem., 66/7, 1615-1617 |
Biosci. Biotechnol. Biochem., 66/7, 1615-1617 |
2002 |
Refereed |
English |
Research paper(scientific journal) |
Disclose to all |
A. Morimoto, K. Irie*, K. Murakami, H. Ohigashi, M. Shindo, M. Nagao, T. Shimizu and T. Shirasawa |
A. Morimoto, K. Irie*, K. Murakami, H. Ohigashi, M. Shindo, M. Nagao, T. Shimizu and T. Shirasawa |
A. Morimoto, K. Irie*, K. Murakami, H. Ohigashi, M. Shindo, M. Nagao, T. Shimizu and T. Shirasawa |
Aggregation and neurotoxicity of mutant amyloid beta (Abeta) peptides with proline replacement: importance of turn formation at positions 22 and 23 |
Aggregation and neurotoxicity of mutant amyloid beta (Abeta) peptides with proline replacement: importance of turn formation at positions 22 and 23 |
Aggregation and neurotoxicity of mutant amyloid beta (Abeta) peptides with proline replacement: importance of turn formation at positions 22 and 23 |
Biochem. Biophys. Res. Commun., 295/2, 306-311 |
Biochem. Biophys. Res. Commun., 295/2, 306-311 |
Biochem. Biophys. Res. Commun., 295/2, 306-311 |
2002 |
Refereed |
English |
Research paper(scientific journal) |
Disclose to all |
入江一浩*、大東 肇 |
入江一浩*、大東 肇 |
|
プロテインキナーゼCのシステインリッチドメインの化学合成、機能解析とドラッグデザイン |
プロテインキナーゼCのシステインリッチドメインの化学合成、機能解析とドラッグデザイン |
|
有機合成化学協会誌, 60/6, 563-572 |
有機合成化学協会誌, 60/6, 563-572 |
|
2002 |
Refereed |
Japanese |
Research paper(scientific journal) |
Disclose to all |
K. Irie*, A. Nakahara, Y. Nakagawa, H. Ohigashi, M. Shindo, H. Fukuda, H. Konishi, U. Kikkawa, K. Kashiwagi and N. Saito |
K. Irie*, A. Nakahara, Y. Nakagawa, H. Ohigashi, M. Shindo, H. Fukuda, H. Konishi, U. Kikkawa, K. Kashiwagi and N. Saito |
K. Irie*, A. Nakahara, Y. Nakagawa, H. Ohigashi, M. Shindo, H. Fukuda, H. Konishi, U. Kikkawa, K. Kashiwagi and N. Saito |
Establishment of a binding assay for protein kinase C isozymes using synthetic C1 peptides and development of new medicinal leads with protein kinase C isozyme and C1 domain selectivity |
Establishment of a binding assay for protein kinase C isozymes using synthetic C1 peptides and development of new medicinal leads with protein kinase C isozyme and C1 domain selectivity |
Establishment of a binding assay for protein kinase C isozymes using synthetic C1 peptides and development of new medicinal leads with protein kinase C isozyme and C1 domain selectivity |
Pharmacol. Ther., 93/2-3, 271-281 |
Pharmacol. Ther., 93/2-3, 271-281 |
Pharmacol. Ther., 93/2-3, 271-281 |
2002 |
Refereed |
English |
Research paper(scientific journal) |
Disclose to all |
M. Tanaka, K. Irie*, Y. Nakagawa, Y. Nakamura, H. Ohigashi and P. A. Wender |
M. Tanaka, K. Irie*, Y. Nakagawa, Y. Nakamura, H. Ohigashi and P. A. Wender |
M. Tanaka, K. Irie*, Y. Nakagawa, Y. Nakamura, H. Ohigashi and P. A. Wender |
The C4 hydroxyl group of phorbol esters is not necessary for protein kinase C binding |
The C4 hydroxyl group of phorbol esters is not necessary for protein kinase C binding |
The C4 hydroxyl group of phorbol esters is not necessary for protein kinase C binding |
Bioorg. Med. Chem. Lett., 11/5, 719-722 |
Bioorg. Med. Chem. Lett., 11/5, 719-722 |
Bioorg. Med. Chem. Lett., 11/5, 719-722 |
2001 |
Refereed |
English |
Research paper(scientific journal) |
Disclose to all |
Y. Nakagawa, K. Irie*, Y. Nakamura and H. Ohigashi |
Y. Nakagawa, K. Irie*, Y. Nakamura and H. Ohigashi |
Y. Nakagawa, K. Irie*, Y. Nakamura and H. Ohigashi |
The amide hydrogen of (-)-indolactam-V and benzolactam-V8's plays a critical role in protein kinase C binding and tumor-promoting activities |
The amide hydrogen of (-)-indolactam-V and benzolactam-V8's plays a critical role in protein kinase C binding and tumor-promoting activities |
The amide hydrogen of (-)-indolactam-V and benzolactam-V8's plays a critical role in protein kinase C binding and tumor-promoting activities |
Bioorg. Med. Chem. Lett., 11/5, 723-728 |
Bioorg. Med. Chem. Lett., 11/5, 723-728 |
Bioorg. Med. Chem. Lett., 11/5, 723-728 |
2001 |
Refereed |
English |
Research paper(scientific journal) |
Disclose to all |
M. Shindo, K. Irie*, A. Nakahara, H. Ohigashi, H. Konishi, U. Kikkawa, H. Fukuda and P. A. Wender |
M. Shindo, K. Irie*, A. Nakahara, H. Ohigashi, H. Konishi, U. Kikkawa, H. Fukuda and P. A. Wender |
M. Shindo, K. Irie*, A. Nakahara, H. Ohigashi, H. Konishi, U. Kikkawa, H. Fukuda and P. A. Wender |
Toward the identification of selective modulators of protein kinase C (PKC) isozymes: establishment of a binding assay for PKC isozymes using synthetic C1 peptide receptors and identification of the critical residues involved in the phorbol ester binding |
Toward the identification of selective modulators of protein kinase C (PKC) isozymes: establishment of a binding assay for PKC isozymes using synthetic C1 peptide receptors and identification of the critical residues involved in the phorbol ester binding |
Toward the identification of selective modulators of protein kinase C (PKC) isozymes: establishment of a binding assay for PKC isozymes using synthetic C1 peptide receptors and identification of the critical residues involved in the phorbol ester binding |
Bioorg. Med. Chem., 9/8, 2073-2081 |
Bioorg. Med. Chem., 9/8, 2073-2081 |
Bioorg. Med. Chem., 9/8, 2073-2081 |
2001 |
Refereed |
English |
Research paper(scientific journal) |
Disclose to all |
M. Shindo, K. Irie*, H. Ohigashi, M. Kuriyama and N. Saito |
M. Shindo, K. Irie*, H. Ohigashi, M. Kuriyama and N. Saito |
M. Shindo, K. Irie*, H. Ohigashi, M. Kuriyama and N. Saito |
Diacylglycerol kinase gamma is one of the specific receptors of tumor-promoting phorbol esters |
Diacylglycerol kinase gamma is one of the specific receptors of tumor-promoting phorbol esters |
Diacylglycerol kinase gamma is one of the specific receptors of tumor-promoting phorbol esters |
Biochem. Biophys. Res. Commun., 289/2, 451-456 |
Biochem. Biophys. Res. Commun., 289/2, 451-456 |
Biochem. Biophys. Res. Commun., 289/2, 451-456 |
2001 |
Refereed |
English |
Research paper(scientific journal) |
Disclose to all |
Y. Nakagawa, K. Irie*, H. Ohigashi, H. Hayashi and P. A. Wender |
Y. Nakagawa, K. Irie*, H. Ohigashi, H. Hayashi and P. A. Wender |
Y. Nakagawa, K. Irie*, H. Ohigashi, H. Hayashi and P. A. Wender |
Synthesis and PKC isozyme surrogate binding of indothiolactam-V, a new thioamide analogue of tumor promoting indolactam-V |
Synthesis and PKC isozyme surrogate binding of indothiolactam-V, a new thioamide analogue of tumor promoting indolactam-V |
Synthesis and PKC isozyme surrogate binding of indothiolactam-V, a new thioamide analogue of tumor promoting indolactam-V |
Bioorg. Med. Chem. Lett., 10/18, 2087-2090 |
Bioorg. Med. Chem. Lett., 10/18, 2087-2090 |
Bioorg. Med. Chem. Lett., 10/18, 2087-2090 |
2000 |
Refereed |
English |
Research paper(scientific journal) |
Disclose to all |
K. Irie*, A. Nakahara, Y. Ikawa, M. Tanaka, Y. Nakagawa, Y. Nakamura, H. Ohigashi and P. A. Wender |
K. Irie*, A. Nakahara, Y. Ikawa, M. Tanaka, Y. Nakagawa, Y. Nakamura, H. Ohigashi and P. A. Wender |
K. Irie*, A. Nakahara, Y. Ikawa, M. Tanaka, Y. Nakagawa, Y. Nakamura, H. Ohigashi and P. A. Wender |
Synthesis and tumor-promoting activities of 12-epi-phorbol-12,13-dibutyrate |
Synthesis and tumor-promoting activities of 12-epi-phorbol-12,13-dibutyrate |
Synthesis and tumor-promoting activities of 12-epi-phorbol-12,13-dibutyrate |
Biosci. Biotechnol. Biochem., 64/11, 2429-2436 |
Biosci. Biotechnol. Biochem., 64/11, 2429-2436 |
Biosci. Biotechnol. Biochem., 64/11, 2429-2436 |
2000 |
Refereed |
English |
Research paper(scientific journal) |
Disclose to all |
中川 優*, 入江 一浩 |
中川 優*, 入江 一浩 |
|
発がんプロモーターのnPKC C1Bドメインへの選択的結合 |
発がんプロモーターのnPKC C1Bドメインへの選択的結合 |
|
バイオサイエンスとインダストリー, 58/8, 570-571 |
バイオサイエンスとインダストリー, 58/8, 570-571 |
|
2000 |
Refereed |
Japanese |
Research paper(scientific journal) |
Disclose to all |
H. Fukuda, K. Irie*, A. Nakahara, H. Ohigashi and P. A. Wender |
H. Fukuda, K. Irie*, A. Nakahara, H. Ohigashi and P. A. Wender |
H. Fukuda, K. Irie*, A. Nakahara, H. Ohigashi and P. A. Wender |
Solid-phase synthesis, mass spectrometic analysis of the zinc-folding, and phorbol ester-binding studies of the 116-mer peptide containing the tandem cysteine-rich C1 domains of protein kinase C gamma |
Solid-phase synthesis, mass spectrometic analysis of the zinc-folding, and phorbol ester-binding studies of the 116-mer peptide containing the tandem cysteine-rich C1 domains of protein kinase C gamma |
Solid-phase synthesis, mass spectrometic analysis of the zinc-folding, and phorbol ester-binding studies of the 116-mer peptide containing the tandem cysteine-rich C1 domains of protein kinase C gamma |
Bioorg. Med. Chem., 7/6, 1213-1221 |
Bioorg. Med. Chem., 7/6, 1213-1221 |
Bioorg. Med. Chem., 7/6, 1213-1221 |
1999 |
Refereed |
English |
Research paper(scientific journal) |
Disclose to all |
P. A. Wender*, B. Lippa, C.-M. Park, K. Irie, A. Nakahara and H. Ohigashi |
P. A. Wender*, B. Lippa, C.-M. Park, K. Irie, A. Nakahara and H. Ohigashi |
P. A. Wender*, B. Lippa, C.-M. Park, K. Irie, A. Nakahara and H. Ohigashi |
Selective binding of bryostatin analogues to the cysteine rich domains of protein kinase C isozymes |
Selective binding of bryostatin analogues to the cysteine rich domains of protein kinase C isozymes |
Selective binding of bryostatin analogues to the cysteine rich domains of protein kinase C isozymes |
Bioorg. Med. Chem. Lett., 9/12, 1687-1690 |
Bioorg. Med. Chem. Lett., 9/12, 1687-1690 |
Bioorg. Med. Chem. Lett., 9/12, 1687-1690 |
1999 |
Refereed |
English |
Research paper(scientific journal) |
Disclose to all |
K. Irie*, A. Nakahara, H. Ohigashi, H. Fukuda, P. A. Wender, H. Konishi and U. Kikkawa |
K. Irie*, A. Nakahara, H. Ohigashi, H. Fukuda, P. A. Wender, H. Konishi and U. Kikkawa |
K. Irie*, A. Nakahara, H. Ohigashi, H. Fukuda, P. A. Wender, H. Konishi and U. Kikkawa |
Synthesis and phorbol ester-binding studies of the individual cysteine-rich motifs of protein kinase D |
Synthesis and phorbol ester-binding studies of the individual cysteine-rich motifs of protein kinase D |
Synthesis and phorbol ester-binding studies of the individual cysteine-rich motifs of protein kinase D |
Bioorg. Med. Chem. Lett., 9/17, 2487-2490 |
Bioorg. Med. Chem. Lett., 9/17, 2487-2490 |
Bioorg. Med. Chem. Lett., 9/17, 2487-2490 |
1999 |
Refereed |
English |
Research paper(scientific journal) |
Disclose to all |
P. A. Wender*, M. F. T. Koehler, D. L. Wright and K. Irie |
P. A. Wender*, M. F. T. Koehler, D. L. Wright and K. Irie |
P. A. Wender*, M. F. T. Koehler, D. L. Wright and K. Irie |
Mapping phorbol ester binding domains of protein kinase C (PKC) : the design, synthesis and biological activity of novel phorbol ester dimers |
Mapping phorbol ester binding domains of protein kinase C (PKC) : the design, synthesis and biological activity of novel phorbol ester dimers |
Mapping phorbol ester binding domains of protein kinase C (PKC) : the design, synthesis and biological activity of novel phorbol ester dimers |
Synthesis, /SI, 1401-1406 |
Synthesis, /SI, 1401-1406 |
Synthesis, /SI, 1401-1406 |
1999 |
Refereed |
English |
Research paper(scientific journal) |
Disclose to all |
K. Irie*, S. Tomimatsu, Y. Nakagawa, H. Ohigashi and H. Hayashi |
K. Irie*, S. Tomimatsu, Y. Nakagawa, H. Ohigashi and H. Hayashi |
K. Irie*, S. Tomimatsu, Y. Nakagawa, H. Ohigashi and H. Hayashi |
Isolation of (-)-14-O-malonylindolactam-V as a possible precursor of (-)-14-O-acetylindolactam-V from Streptomyces blastmyceticum |
Isolation of (-)-14-O-malonylindolactam-V as a possible precursor of (-)-14-O-acetylindolactam-V from Streptomyces blastmyceticum |
Isolation of (-)-14-O-malonylindolactam-V as a possible precursor of (-)-14-O-acetylindolactam-V from Streptomyces blastmyceticum |
Biosci. Biotechnol. Biochem., 63/9, 1669-1670 |
Biosci. Biotechnol. Biochem., 63/9, 1669-1670 |
Biosci. Biotechnol. Biochem., 63/9, 1669-1670 |
1999 |
Refereed |
English |
Research paper(scientific journal) |
Disclose to all |
P. A. Wender*, T. A. Kirschberg, P. D. Williams, H. M. M. Bastiaans and K. Irie |
P. A. Wender*, T. A. Kirschberg, P. D. Williams, H. M. M. Bastiaans and K. Irie |
P. A. Wender*, T. A. Kirschberg, P. D. Williams, H. M. M. Bastiaans and K. Irie |
A new class of simplified phorbol ester analogues : synthesis and binding to PKC and ηPKC-C1B (ηPKC-CRD2) |
A new class of simplified phorbol ester analogues : synthesis and binding to PKC and ηPKC-C1B (ηPKC-CRD2) |
A new class of simplified phorbol ester analogues : synthesis and binding to PKC and ηPKC-C1B (ηPKC-CRD2) |
Org. Lett., 1/7, 1009-1012 |
Org. Lett., 1/7, 1009-1012 |
Org. Lett., 1/7, 1009-1012 |
1999 |
Refereed |
English |
Research paper(scientific journal) |
Disclose to all |
Y. Nakagawa, K. Irie*, Y. Nakamura, H. Ohigashi and H. Hayashi |
Y. Nakagawa, K. Irie*, Y. Nakamura, H. Ohigashi and H. Hayashi |
Y. Nakagawa, K. Irie*, Y. Nakamura, H. Ohigashi and H. Hayashi |
Synthesis and biological activities of (-)-6-n-octyl-indolactam-V, a new potent analogue of the tumor promoter (-)-indolactam-V |
Synthesis and biological activities of (-)-6-n-octyl-indolactam-V, a new potent analogue of the tumor promoter (-)-indolactam-V |
Synthesis and biological activities of (-)-6-n-octyl-indolactam-V, a new potent analogue of the tumor promoter (-)-indolactam-V |
Biosci. Biotechnol. Biochem., 62/8, 1568-1573 |
Biosci. Biotechnol. Biochem., 62/8, 1568-1573 |
Biosci. Biotechnol. Biochem., 62/8, 1568-1573 |
1998 |
Refereed |
English |
Research paper(scientific journal) |
Disclose to all |
K. Irie*, K. Oie, A. Nakahara, Y. Yanai, H. Ohigashi, P. A. Wender*, H. Fukuda, H. Konishi and U. Kikkawa |
K. Irie*, K. Oie, A. Nakahara, Y. Yanai, H. Ohigashi, P. A. Wender*, H. Fukuda, H. Konishi and U. Kikkawa |
K. Irie*, K. Oie, A. Nakahara, Y. Yanai, H. Ohigashi, P. A. Wender*, H. Fukuda, H. Konishi and U. Kikkawa |
Molecular Basis for protein kinase C isozyme-selective binding : the synthesis, folding, and phorbol ester binding of the cysteine-rich domains of all protein kinase C isozymes |
Molecular Basis for protein kinase C isozyme-selective binding : the synthesis, folding, and phorbol ester binding of the cysteine-rich domains of all protein kinase C isozymes |
Molecular Basis for protein kinase C isozyme-selective binding : the synthesis, folding, and phorbol ester binding of the cysteine-rich domains of all protein kinase C isozymes |
J. Am. Chem. Soc., 120/36, 9159-9167 |
J. Am. Chem. Soc., 120/36, 9159-9167 |
J. Am. Chem. Soc., 120/36, 9159-9167 |
1998 |
Refereed |
English |
Research paper(scientific journal) |
Disclose to all |
K. Irie*, Y. Nakagawa, S. Tomimatsu and H. Ohigashi |
K. Irie*, Y. Nakagawa, S. Tomimatsu and H. Ohigashi |
K. Irie*, Y. Nakagawa, S. Tomimatsu and H. Ohigashi |
Biosynthesis of the monoterpenoid moiety of teleocidins via the non-mevalonate pathway in Streptomyces |
Biosynthesis of the monoterpenoid moiety of teleocidins via the non-mevalonate pathway in Streptomyces |
Biosynthesis of the monoterpenoid moiety of teleocidins via the non-mevalonate pathway in Streptomyces |
Tetrahedron Lett., 39/43, 7929-7930 |
Tetrahedron Lett., 39/43, 7929-7930 |
Tetrahedron Lett., 39/43, 7929-7930 |
1998 |
Refereed |
English |
Research paper(scientific journal) |
Disclose to all |
H. Fukuda, K. Irie*, A. Nakahara, K. Oie, H. Ohigashi and P. A. Wender |
H. Fukuda, K. Irie*, A. Nakahara, K. Oie, H. Ohigashi and P. A. Wender |
H. Fukuda, K. Irie*, A. Nakahara, K. Oie, H. Ohigashi and P. A. Wender |
Synthesis and binding studies of the 116-mer peptide containing the double cysteine-rich motifs of protein kinase C gamma |
Synthesis and binding studies of the 116-mer peptide containing the double cysteine-rich motifs of protein kinase C gamma |
Synthesis and binding studies of the 116-mer peptide containing the double cysteine-rich motifs of protein kinase C gamma |
Tetrahedron Lett., 39/43, 7943-7946 |
Tetrahedron Lett., 39/43, 7943-7946 |
Tetrahedron Lett., 39/43, 7943-7946 |
1998 |
Refereed |
English |
Research paper(scientific journal) |
Disclose to all |
入江 一浩 |
入江 一浩 |
|
プロテインキナーゼ機能ドメインの化学合成 |
プロテインキナーゼ機能ドメインの化学合成 |
|
バイオサイエンスとインダストリー, 56/8, 541-544 |
バイオサイエンスとインダストリー, 56/8, 541-544 |
|
1998 |
Refereed |
Japanese |
Research paper(scientific journal) |
Disclose to all |
入江 一浩 |
入江 一浩 |
|
ビオチンを用いた新しい光アフィニティーラベリング法の開発と応用 |
ビオチンを用いた新しい光アフィニティーラベリング法の開発と応用 |
|
化学と工業, 51/10, 1634 |
化学と工業, 51/10, 1634 |
|
1998 |
|
Japanese |
Research paper(scientific journal) |
Disclose to all |
P. A. Wender*, Y. M.-Cantalejo, A. J. Carpenter, A. Chiu, J. De Brabander, P.G. Harran, J.-M. Jimenez, M. F. T. Koehler, B. Lippa, J. A. Morrison, S. G. Mϋller, S. N. Mϋller, C.-M. Park, M. Shiozaki, C. Siedenbiedel, D. J. Skalitzky, M. Tanaka and K. Irie |
P. A. Wender*, Y. M.-Cantalejo, A. J. Carpenter, A. Chiu, J. De Brabander, P.G. Harran, J.-M. Jimenez, M. F. T. Koehler, B. Lippa, J. A. Morrison, S. G. Mϋller, S. N. Mϋller, C.-M. Park, M. Shiozaki, C. Siedenbiedel, D. J. Skalitzky, M. Tanaka and K. Irie |
P. A. Wender*, Y. M.-Cantalejo, A. J. Carpenter, A. Chiu, J. De Brabander, P.G. Harran, J.-M. Jimenez, M. F. T. Koehler, B. Lippa, J. A. Morrison, S. G. Mϋller, S. N. Mϋller, C.-M. Park, M. Shiozaki, C. Siedenbiedel, D. J. Skalitzky, M. Tanaka and K. Irie |
The chemistry-medicine continuum: synthetic, computer, spectroscopic and biological studies on new chemotherapeutic leads |
The chemistry-medicine continuum: synthetic, computer, spectroscopic and biological studies on new chemotherapeutic leads |
The chemistry-medicine continuum: synthetic, computer, spectroscopic and biological studies on new chemotherapeutic leads |
Pure & Appl. Chem.,70/3, 539-546 |
Pure & Appl. Chem.,70/3, 539-546 |
Pure & Appl. Chem.,70/3, 539-546 |
1998 |
Refereed |
English |
Research paper(scientific journal) |
Disclose to all |
Y. Nakagawa, K. Irie*, Y. Nakamura, H. Ohigashi and H. Hayashi |
Y. Nakagawa, K. Irie*, Y. Nakamura, H. Ohigashi and H. Hayashi |
Y. Nakagawa, K. Irie*, Y. Nakamura, H. Ohigashi and H. Hayashi |
Synthesis and biological activities of indolactone-V, the lactone analogue of the tumor promoter (-)-indolactam-V |
Synthesis and biological activities of indolactone-V, the lactone analogue of the tumor promoter (-)-indolactam-V |
Synthesis and biological activities of indolactone-V, the lactone analogue of the tumor promoter (-)-indolactam-V |
Biosci. Biotechnol. Biochem., 61/8, 1415-1417 |
Biosci. Biotechnol. Biochem., 61/8, 1415-1417 |
Biosci. Biotechnol. Biochem., 61/8, 1415-1417 |
1997 |
Refereed |
English |
Research paper(scientific journal) |
Disclose to all |
Y. Yanai, K. Irie*, H. Ohigashi and P. A. Wender* |
Y. Yanai, K. Irie*, H. Ohigashi and P. A. Wender* |
Y. Yanai, K. Irie*, H. Ohigashi and P. A. Wender* |
Synthesis and characterization of the first cysteine-rich domain of novel protein kinase C |
Synthesis and characterization of the first cysteine-rich domain of novel protein kinase C |
Synthesis and characterization of the first cysteine-rich domain of novel protein kinase C |
Bioorg. Med. Chem. Lett., 7/2, 117-122 |
Bioorg. Med. Chem. Lett., 7/2, 117-122 |
Bioorg. Med. Chem. Lett., 7/2, 117-122 |
1997 |
Refereed |
English |
Research paper(scientific journal) |
Disclose to all |
K. Irie*, Y. Yanai, K. Oie, H. Ohigashi and P. A. Wender* |
K. Irie*, Y. Yanai, K. Oie, H. Ohigashi and P. A. Wender* |
K. Irie*, Y. Yanai, K. Oie, H. Ohigashi and P. A. Wender* |
Protein kinase C regulatory domain surrogate peptides : effects of metal ions on folding, phorbol ester-binding, and selectivity |
Protein kinase C regulatory domain surrogate peptides : effects of metal ions on folding, phorbol ester-binding, and selectivity |
Protein kinase C regulatory domain surrogate peptides : effects of metal ions on folding, phorbol ester-binding, and selectivity |
Bioorg. Med. Chem. Lett., 7/8, 965-970 |
Bioorg. Med. Chem. Lett., 7/8, 965-970 |
Bioorg. Med. Chem. Lett., 7/8, 965-970 |
1997 |
Refereed |
English |
Research paper(scientific journal) |
Disclose to all |
K. Irie*, Y. Yanai, K. Oie, J. Ishizawa, Y. Nakagawa, H. Ohigashi, P. A. Wender* and U. Kikkawa |
K. Irie*, Y. Yanai, K. Oie, J. Ishizawa, Y. Nakagawa, H. Ohigashi, P. A. Wender* and U. Kikkawa |
K. Irie*, Y. Yanai, K. Oie, J. Ishizawa, Y. Nakagawa, H. Ohigashi, P. A. Wender* and U. Kikkawa |
Comparison of chemical characteristics of the first and the second cysteine-rich domains of protein kinase Cγ |
Comparison of chemical characteristics of the first and the second cysteine-rich domains of protein kinase Cγ |
Comparison of chemical characteristics of the first and the second cysteine-rich domains of protein kinase Cγ |
Bioorg. Med. Chem., 5/8, 1725-1737 |
Bioorg. Med. Chem., 5/8, 1725-1737 |
Bioorg. Med. Chem., 5/8, 1725-1737 |
1997 |
Refereed |
English |
Research paper(scientific journal) |
Disclose to all |
入江 一浩 |
入江 一浩 |
|
プロテインキナーゼCの2つのzinc finger モチーフの機能と役割 |
プロテインキナーゼCの2つのzinc finger モチーフの機能と役割 |
|
化学と生物, 35/9, 638-639 |
化学と生物, 35/9, 638-639 |
|
1997 |
Refereed |
Japanese |
Research paper(scientific journal) |
Disclose to all |
K. Irie*, T. Isaka, Y. Iwata, Y. Yanai, Y. Nakamura, F. Koizumi, H. Ohigashi, P. A. Wender*, Y. Satomi and H. Nishino |
K. Irie*, T. Isaka, Y. Iwata, Y. Yanai, Y. Nakamura, F. Koizumi, H. Ohigashi, P. A. Wender*, Y. Satomi and H. Nishino |
K. Irie*, T. Isaka, Y. Iwata, Y. Yanai, Y. Nakamura, F. Koizumi, H. Ohigashi, P. A. Wender*, Y. Satomi and H. Nishino |
Synthesis and biological activities of new conformationally restricted analogues of (-)-indolactam-V: elucidation of the biologically active conformation of the tumor promoting teleocidins |
Synthesis and biological activities of new conformationally restricted analogues of (-)-indolactam-V: elucidation of the biologically active conformation of the tumor promoting teleocidins |
Synthesis and biological activities of new conformationally restricted analogues of (-)-indolactam-V: elucidation of the biologically active conformation of the tumor promoting teleocidins |
J. Am. Chem. Soc., 118/44, 10733-10743 |
J. Am. Chem. Soc., 118/44, 10733-10743 |
J. Am. Chem. Soc., 118/44, 10733-10743 |
1996 |
Refereed |
English |
Research paper(scientific journal) |
Disclose to all |
K. Irie*, T. Ishii, H. Ohigashi, P. A. Wender*, B. L. Miller and N. Takeda |
K. Irie*, T. Ishii, H. Ohigashi, P. A. Wender*, B. L. Miller and N. Takeda |
K. Irie*, T. Ishii, H. Ohigashi, P. A. Wender*, B. L. Miller and N. Takeda |
Synthesis and characterization of new photolabile phorbol esters for affinity labeling of protein kinase C |
Synthesis and characterization of new photolabile phorbol esters for affinity labeling of protein kinase C |
Synthesis and characterization of new photolabile phorbol esters for affinity labeling of protein kinase C |
J. Org. Chem., 61/6, 2164-2173 |
J. Org. Chem., 61/6, 2164-2173 |
J. Org. Chem., 61/6, 2164-2173 |
1996 |
Refereed |
English |
Research paper(scientific journal) |
Disclose to all |
K. Irie*, Y. Yanai, H. Ohigashi, P. A. Wender* and B. L. Miller |
K. Irie*, Y. Yanai, H. Ohigashi, P. A. Wender* and B. L. Miller |
K. Irie*, Y. Yanai, H. Ohigashi, P. A. Wender* and B. L. Miller |
Synthesis and characterization of the second cysteine-rich region of mouse skin PKCη |
Synthesis and characterization of the second cysteine-rich region of mouse skin PKCη |
Synthesis and characterization of the second cysteine-rich region of mouse skin PKCη |
Bioorg. Med. Chem. Lett., 6/4, 353-356 |
Bioorg. Med. Chem. Lett., 6/4, 353-356 |
Bioorg. Med. Chem. Lett., 6/4, 353-356 |
1996 |
Refereed |
English |
Research paper(scientific journal) |
Disclose to all |
K. Irie*, Y. Nakamura, H. Ohigashi, H. Tokuyama, S. Yamago and E. Nakamura |
K. Irie*, Y. Nakamura, H. Ohigashi, H. Tokuyama, S. Yamago and E. Nakamura |
K. Irie*, Y. Nakamura, H. Ohigashi, H. Tokuyama, S. Yamago and E. Nakamura |
Photocytotoxicity of water-soluble fullerene derivatives |
Photocytotoxicity of water-soluble fullerene derivatives |
Photocytotoxicity of water-soluble fullerene derivatives |
Biosci. Biotechnol. Biochem., 60/8, 1359-1361 |
Biosci. Biotechnol. Biochem., 60/8, 1359-1361 |
Biosci. Biotechnol. Biochem., 60/8, 1359-1361 |
1996 |
Refereed |
English |
Research paper(scientific journal) |
Disclose to all |
入江 一浩 |
入江 一浩 |
|
プロテインキナーゼCのホルボールエステル結合部位の光アフィニティーテベリングによる構造解析 |
プロテインキナーゼCのホルボールエステル結合部位の光アフィニティーテベリングによる構造解析 |
|
生化学, 68/2, 129-132 |
生化学, 68/2, 129-132 |
|
1996 |
Refereed |
Japanese |
Research paper(scientific journal) |
Disclose to all |
入江 一浩*, 大東 肇 |
入江 一浩*, 大東 肇 |
|
プロテインキナーゼCのホルボールエステル結合部位の合成と化学的特性 |
プロテインキナーゼCのホルボールエステル結合部位の合成と化学的特性 |
|
有機合成化学協会誌, 54/12, 1024-1033 |
有機合成化学協会誌, 54/12, 1024-1033 |
|
1996 |
Refereed |
Japanese |
Research paper(scientific journal) |
Disclose to all |
P. A. Wender*, K. Irie and B. L. Miller |
P. A. Wender*, K. Irie and B. L. Miller |
P. A. Wender*, K. Irie and B. L. Miller |
Identification, activity, and structural studies of peptides incorporating the phorbol ester-binding domain of protein kinase C |
Identification, activity, and structural studies of peptides incorporating the phorbol ester-binding domain of protein kinase C |
Identification, activity, and structural studies of peptides incorporating the phorbol ester-binding domain of protein kinase C |
Proc. Natl. Acad. Sci. USA, 92/1, 239-243 |
Proc. Natl. Acad. Sci. USA, 92/1, 239-243 |
Proc. Natl. Acad. Sci. USA, 92/1, 239-243 |
1995 |
Refereed |
English |
Research paper(scientific journal) |
Disclose to all |
K. Irie*, M. Iguchi, T. Oda, Y. Suzuki, S. Okuno, H. Ohigashi, K. Koshimizu, H. Hayashi, M. Arai, H. Nishino and A. Iwashima |
K. Irie*, M. Iguchi, T. Oda, Y. Suzuki, S. Okuno, H. Ohigashi, K. Koshimizu, H. Hayashi, M. Arai, H. Nishino and A. Iwashima |
K. Irie*, M. Iguchi, T. Oda, Y. Suzuki, S. Okuno, H. Ohigashi, K. Koshimizu, H. Hayashi, M. Arai, H. Nishino and A. Iwashima |
Synthesis of 6-substituted indolactams by microbial conversion |
Synthesis of 6-substituted indolactams by microbial conversion |
Synthesis of 6-substituted indolactams by microbial conversion |
Tetrahedron, 51/22, 6255-6266 |
Tetrahedron, 51/22, 6255-6266 |
Tetrahedron, 51/22, 6255-6266 |
1995 |
Refereed |
English |
Research paper(scientific journal) |
Disclose to all |
K. Irie*, F. Koizumi, Y. Iwata, T. Ishii, Y. Yanai, Y. Nakamura, H. Ohigashi and P. A. Wender |
K. Irie*, F. Koizumi, Y. Iwata, T. Ishii, Y. Yanai, Y. Nakamura, H. Ohigashi and P. A. Wender |
K. Irie*, F. Koizumi, Y. Iwata, T. Ishii, Y. Yanai, Y. Nakamura, H. Ohigashi and P. A. Wender |
Synthesis and biological activities of new conformationally fixed analogues of (-)-indolactam-V, the core structure of tumor-promoting teleocidins |
Synthesis and biological activities of new conformationally fixed analogues of (-)-indolactam-V, the core structure of tumor-promoting teleocidins |
Synthesis and biological activities of new conformationally fixed analogues of (-)-indolactam-V, the core structure of tumor-promoting teleocidins |
Bioorg. Med. Chem. Lett., 5/5, 453-458 |
Bioorg. Med. Chem. Lett., 5/5, 453-458 |
Bioorg. Med. Chem. Lett., 5/5, 453-458 |
1995 |
Refereed |
English |
Research paper(scientific journal) |
Disclose to all |
S. Okuno, K. Irie*, Y. Suzuki, K. Koshimizu, H. Nishino and A. Iwashima |
S. Okuno, K. Irie*, Y. Suzuki, K. Koshimizu, H. Nishino and A. Iwashima |
S. Okuno, K. Irie*, Y. Suzuki, K. Koshimizu, H. Nishino and A. Iwashima |
Synthesis and biological activities of fluorine-substituted (-)-indolactam-V, the core structure of tumor promoter teleocidins |
Synthesis and biological activities of fluorine-substituted (-)-indolactam-V, the core structure of tumor promoter teleocidins |
Synthesis and biological activities of fluorine-substituted (-)-indolactam-V, the core structure of tumor promoter teleocidins |
Bioorg. Med. Chem. Lett., 4/3, 431-434 |
Bioorg. Med. Chem. Lett., 4/3, 431-434 |
Bioorg. Med. Chem. Lett., 4/3, 431-434 |
1994 |
Refereed |
English |
Research paper(scientific journal) |
Disclose to all |
K. Irie*, S. Kajiyama, S. Okuno, M. Kondo, K. Koshimizu, H. Hayashi, M. Arai, H. Nishino and A. Iwashima |
K. Irie*, S. Kajiyama, S. Okuno, M. Kondo, K. Koshimizu, H. Hayashi, M. Arai, H. Nishino and A. Iwashima |
K. Irie*, S. Kajiyama, S. Okuno, M. Kondo, K. Koshimizu, H. Hayashi, M. Arai, H. Nishino and A. Iwashima |
New teleocidin-related metabolites, (-)-7-geranylindolactam-V and blastmycetin F, from Streptoverticillium blastmyceticum |
New teleocidin-related metabolites, (-)-7-geranylindolactam-V and blastmycetin F, from Streptoverticillium blastmyceticum |
New teleocidin-related metabolites, (-)-7-geranylindolactam-V and blastmycetin F, from Streptoverticillium blastmyceticum |
J. Nat. Prod., 57/3, 363-368 |
J. Nat. Prod., 57/3, 363-368 |
J. Nat. Prod., 57/3, 363-368 |
1994 |
Refereed |
English |
Research paper(scientific journal) |
Disclose to all |
入江 一浩 |
入江 一浩 |
|
発癌プロモーター・テレオシジンの作用機構に関する有機化学的研究 |
発癌プロモーター・テレオシジンの作用機構に関する有機化学的研究 |
|
日本農芸化学会誌, 68/9, 1289-1296 |
日本農芸化学会誌, 68/9, 1289-1296 |
|
1994 |
Refereed |
Japanese |
Research paper(scientific journal) |
Disclose to all |
K. Irie*, S. Okuno, F. Koizumi and K. Koshimizu |
K. Irie*, S. Okuno, F. Koizumi and K. Koshimizu |
K. Irie*, S. Okuno, F. Koizumi and K. Koshimizu |
Photolabile derivatives of indole alkaloid tumor promoter teleocidins : synthesis, biological activities and photoaffinity labeling studies |
Photolabile derivatives of indole alkaloid tumor promoter teleocidins : synthesis, biological activities and photoaffinity labeling studies |
Photolabile derivatives of indole alkaloid tumor promoter teleocidins : synthesis, biological activities and photoaffinity labeling studies |
Tetrahedron, 49/47, 10817-10830 |
Tetrahedron, 49/47, 10817-10830 |
Tetrahedron, 49/47, 10817-10830 |
1993 |
Refereed |
English |
Research paper(scientific journal) |
Disclose to all |
T. Ando, K. Irie*, K. Koshimizu, T. Takemura, H. Nishino, A. Iwashima, N. Takeda, S. Nakajima and I. Sakata |
T. Ando, K. Irie*, K. Koshimizu, T. Takemura, H. Nishino, A. Iwashima, N. Takeda, S. Nakajima and I. Sakata |
T. Ando, K. Irie*, K. Koshimizu, T. Takemura, H. Nishino, A. Iwashima, N. Takeda, S. Nakajima and I. Sakata |
Photocytotoxicity of water-soluble metalloporphyrin derivatives |
Photocytotoxicity of water-soluble metalloporphyrin derivatives |
Photocytotoxicity of water-soluble metalloporphyrin derivatives |
Photochem. Photobiol., 57/4, 629-633 |
Photochem. Photobiol., 57/4, 629-633 |
Photochem. Photobiol., 57/4, 629-633 |
1993 |
Refereed |
English |
Research paper(scientific journal) |
Disclose to all |
P. A. Wender*, K. Irie and B. L. Miller |
P. A. Wender*, K. Irie and B. L. Miller |
P. A. Wender*, K. Irie and B. L. Miller |
Synthesis and binding of photoaffinity ligand candidates for protein kinase C |
Synthesis and binding of photoaffinity ligand candidates for protein kinase C |
Synthesis and binding of photoaffinity ligand candidates for protein kinase C |
J. Org. Chem., 58/16, 4179-4181 |
J. Org. Chem., 58/16, 4179-4181 |
J. Org. Chem., 58/16, 4179-4181 |
1993 |
Refereed |
English |
Research paper(scientific journal) |
Disclose to all |
K. Irie* and K. Koshimizu |
K. Irie* and K. Koshimizu |
K. Irie* and K. Koshimizu |
Chemistry of indole alkaloid tumor promoter teleocidins |
Chemistry of indole alkaloid tumor promoter teleocidins |
Chemistry of indole alkaloid tumor promoter teleocidins |
Comments Agric. & Food Chemistry,3/1, 1-25 |
Comments Agric. & Food Chemistry,3/1, 1-25 |
Comments Agric. & Food Chemistry,3/1, 1-25 |
1993 |
Refereed |
English |
Research paper(scientific journal) |
Disclose to all |
入江 一浩*, 小清水 弘一 |
入江 一浩*, 小清水 弘一 |
|
腫瘍親和性光増感剤ヘマトポルフィリン誘導体の活性成分は? |
腫瘍親和性光増感剤ヘマトポルフィリン誘導体の活性成分は? |
|
化学, 47/2, 142 |
化学, 47/2, 142 |
|
1992 |
|
Japanese |
Research paper(scientific journal) |
Disclose to all |
S. Kajiyama, K. Irie*, T. Kido, K. Koshimizu, H. Hayashi and M.Arai |
S. Kajiyama, K. Irie*, T. Kido, K. Koshimizu, H. Hayashi and M.Arai |
S. Kajiyama, K. Irie*, T. Kido, K. Koshimizu, H. Hayashi and M.Arai |
Synthesis of new indolactam analogues by microbial conversion |
Synthesis of new indolactam analogues by microbial conversion |
Synthesis of new indolactam analogues by microbial conversion |
Tetrahedron, 47/29, 5453-5462 |
Tetrahedron, 47/29, 5453-5462 |
Tetrahedron, 47/29, 5453-5462 |
1991 |
Refereed |
English |
Research paper(scientific journal) |
Disclose to all |
K. Irie*, S. Okuno, S. Kajiyama, K. Koshimizu, H. Nishino and A. Iwashima |
K. Irie*, S. Okuno, S. Kajiyama, K. Koshimizu, H. Nishino and A. Iwashima |
K. Irie*, S. Okuno, S. Kajiyama, K. Koshimizu, H. Nishino and A. Iwashima |
Quantitative structure-activity studies on indole alkaloid tumor promoter indolactam congeners |
Quantitative structure-activity studies on indole alkaloid tumor promoter indolactam congeners |
Quantitative structure-activity studies on indole alkaloid tumor promoter indolactam congeners |
Carcinogenesis, 12/10, 1883-1886 |
Carcinogenesis, 12/10, 1883-1886 |
Carcinogenesis, 12/10, 1883-1886 |
1991 |
Refereed |
English |
Research paper(scientific journal) |
Disclose to all |
T. Ando, K. Irie*, K. Koshimizu, T. Shingu, N. Takeda, T. Takemura, S. Nakajima and I. Sakata |
T. Ando, K. Irie*, K. Koshimizu, T. Shingu, N. Takeda, T. Takemura, S. Nakajima and I. Sakata |
T. Ando, K. Irie*, K. Koshimizu, T. Shingu, N. Takeda, T. Takemura, S. Nakajima and I. Sakata |
New photosensitizers for photodynamic therapy : syntheses of chlorin e6 dimer and trimer |
New photosensitizers for photodynamic therapy : syntheses of chlorin e6 dimer and trimer |
New photosensitizers for photodynamic therapy : syntheses of chlorin e6 dimer and trimer |
Agric. Biol. Chem., 55/9, 2441-2443 |
Agric. Biol. Chem., 55/9, 2441-2443 |
Agric. Biol. Chem., 55/9, 2441-2443 |
1991 |
Refereed |
English |
Research paper(scientific journal) |
Disclose to all |
T. Ando, Y. Suzuki, R. Geka, K. Irie*, K. Koshimizu, T. Takemura, S. Nakajima and I. Sakata |
T. Ando, Y. Suzuki, R. Geka, K. Irie*, K. Koshimizu, T. Takemura, S. Nakajima and I. Sakata |
T. Ando, Y. Suzuki, R. Geka, K. Irie*, K. Koshimizu, T. Takemura, S. Nakajima and I. Sakata |
New water-soluble pyropheophorbide a derivatives as possible agents for photodynamic therapy of cancer |
New water-soluble pyropheophorbide a derivatives as possible agents for photodynamic therapy of cancer |
New water-soluble pyropheophorbide a derivatives as possible agents for photodynamic therapy of cancer |
Tetrahedron Lett., 32/38, 5107-5110 |
Tetrahedron Lett., 32/38, 5107-5110 |
Tetrahedron Lett., 32/38, 5107-5110 |
1991 |
Refereed |
English |
Research paper(scientific journal) |
Disclose to all |
入江 一浩*, 小清水 弘一 |
入江 一浩*, 小清水 弘一 |
|
発癌プロモーターの作用機作解明への有機化学的アプローチ |
発癌プロモーターの作用機作解明への有機化学的アプローチ |
|
有機合成化学協会誌, 49/11, 1070-1079 |
有機合成化学協会誌, 49/11, 1070-1079 |
|
1991 |
Refereed |
Japanese |
Research paper(scientific journal) |
Disclose to all |
K. Irie, S. Kajiyama, A. Funaki, K. Koshimizu*, H.Hayashi and M. Arai |
K. Irie, S. Kajiyama, A. Funaki, K. Koshimizu*, H.Hayashi and M. Arai |
K. Irie, S. Kajiyama, A. Funaki, K. Koshimizu*, H.Hayashi and M. Arai |
Biosynthesis of (-)-indolactam V, the basic ring-structure of tumor poromoters teleocidins |
Biosynthesis of (-)-indolactam V, the basic ring-structure of tumor poromoters teleocidins |
Biosynthesis of (-)-indolactam V, the basic ring-structure of tumor poromoters teleocidins |
Tetrahedron Lett., 31/1, 101-104 |
Tetrahedron Lett., 31/1, 101-104 |
Tetrahedron Lett., 31/1, 101-104 |
1990 |
Refereed |
English |
Research paper(scientific journal) |
Disclose to all |
K. Irie, S. Kajiyama, A. Funaki, K. Koshimizu*, H.Hayashi and M. Arai |
K. Irie, S. Kajiyama, A. Funaki, K. Koshimizu*, H.Hayashi and M. Arai |
K. Irie, S. Kajiyama, A. Funaki, K. Koshimizu*, H.Hayashi and M. Arai |
Biosynthesis of indole alkaloid-tumor promoters teleocidins (I): possible biosynthetic pathway of the monoterpenoid moieties of teleocidins |
Biosynthesis of indole alkaloid-tumor promoters teleocidins (I): possible biosynthetic pathway of the monoterpenoid moieties of teleocidins |
Biosynthesis of indole alkaloid-tumor promoters teleocidins (I): possible biosynthetic pathway of the monoterpenoid moieties of teleocidins |
Tetrahedron, 46/8, 2773-2788 |
Tetrahedron, 46/8, 2773-2788 |
Tetrahedron, 46/8, 2773-2788 |
1990 |
Refereed |
English |
Research paper(scientific journal) |
Disclose to all |
S. Okuno, K. Irie*, H. Nishino, A. Iwashima and K. Koshimizu |
S. Okuno, K. Irie*, H. Nishino, A. Iwashima and K. Koshimizu |
S. Okuno, K. Irie*, H. Nishino, A. Iwashima and K. Koshimizu |
Syntheses and biological activities of photolabile indolactam derivatives; new probes for the receptor analysis of tumor promoters |
Syntheses and biological activities of photolabile indolactam derivatives; new probes for the receptor analysis of tumor promoters |
Syntheses and biological activities of photolabile indolactam derivatives; new probes for the receptor analysis of tumor promoters |
Agric. Biol. Chem., 54/7, 1885-1887 |
Agric. Biol. Chem., 54/7, 1885-1887 |
Agric. Biol. Chem., 54/7, 1885-1887 |
1990 |
Refereed |
English |
Research paper(scientific journal) |
Disclose to all |
T. Kinoshita*, I. Takahashi, E. Kobayashi, T. Tamaoki, K. Irie, K. Koshimizu and T. Osato |
T. Kinoshita*, I. Takahashi, E. Kobayashi, T. Tamaoki, K. Irie, K. Koshimizu and T. Osato |
T. Kinoshita*, I. Takahashi, E. Kobayashi, T. Tamaoki, K. Irie, K. Koshimizu and T. Osato |
Suppression by protein kinase C inhibitors of tumor promoter enhancement of Epstein-Barr virus-induced growth transformation |
Suppression by protein kinase C inhibitors of tumor promoter enhancement of Epstein-Barr virus-induced growth transformation |
Suppression by protein kinase C inhibitors of tumor promoter enhancement of Epstein-Barr virus-induced growth transformation |
Anticancer Res., 10/4, 1051-1054 |
Anticancer Res., 10/4, 1051-1054 |
Anticancer Res., 10/4, 1051-1054 |
1990 |
Refereed |
English |
Research paper(scientific journal) |
Disclose to all |
K. Irie*, S. Kajiyama, K. Koshimizu, H. Hayashi and M.Arai |
K. Irie*, S. Kajiyama, K. Koshimizu, H. Hayashi and M.Arai |
K. Irie*, S. Kajiyama, K. Koshimizu, H. Hayashi and M.Arai |
Isolation and biosynthesis of (-)-indolactam I, a new congener of indole alkaloid tumor promoter teleocidins |
Isolation and biosynthesis of (-)-indolactam I, a new congener of indole alkaloid tumor promoter teleocidins |
Isolation and biosynthesis of (-)-indolactam I, a new congener of indole alkaloid tumor promoter teleocidins |
Tetrahedron Lett., 31/50, 7337-7340 |
Tetrahedron Lett., 31/50, 7337-7340 |
Tetrahedron Lett., 31/50, 7337-7340 |
1990 |
Refereed |
English |
Research paper(scientific journal) |
Disclose to all |
T. Ando, K. Irie*, K. Koshimizu, T. Takemura, H. Nishino, A. Iwashima, S. Nakajima and I. Sakata |
T. Ando, K. Irie*, K. Koshimizu, T. Takemura, H. Nishino, A. Iwashima, S. Nakajima and I. Sakata |
T. Ando, K. Irie*, K. Koshimizu, T. Takemura, H. Nishino, A. Iwashima, S. Nakajima and I. Sakata |
Synthesis, physicochemical properties and photocytotoxicity of five new δ-substituted chlorin e6 derivatives |
Synthesis, physicochemical properties and photocytotoxicity of five new δ-substituted chlorin e6 derivatives |
Synthesis, physicochemical properties and photocytotoxicity of five new δ-substituted chlorin e6 derivatives |
Tetrahedron, 46/17, 5921-5930 |
Tetrahedron, 46/17, 5921-5930 |
Tetrahedron, 46/17, 5921-5930 |
1990 |
Refereed |
English |
Research paper(scientific journal) |
Disclose to all |
K. Irie, S. Okuno, K. Koshimizu*, H. Tokuda, H. Nishino and A. Iwashima |
K. Irie, S. Okuno, K. Koshimizu*, H. Tokuda, H. Nishino and A. Iwashima |
K. Irie, S. Okuno, K. Koshimizu*, H. Tokuda, H. Nishino and A. Iwashima |
Biological activities and cellular uptake studies of fluorescent derivatives of indole alkaloid tumor promoter teleocidin |
Biological activities and cellular uptake studies of fluorescent derivatives of indole alkaloid tumor promoter teleocidin |
Biological activities and cellular uptake studies of fluorescent derivatives of indole alkaloid tumor promoter teleocidin |
Int. J. Cancer, 43/3, 513-519 |
Int. J. Cancer, 43/3, 513-519 |
Int. J. Cancer, 43/3, 513-519 |
1989 |
Refereed |
English |
Research paper(scientific journal) |
Disclose to all |
K. Irie, A. Funaki, K. Koshimizu*, H. Hayashi and M. Arai |
K. Irie, A. Funaki, K. Koshimizu*, H. Hayashi and M. Arai |
K. Irie, A. Funaki, K. Koshimizu*, H. Hayashi and M. Arai |
Structure of blastmycetin E, a new teleocidin-related compound, from Streptoverticillium blastmyceticum |
Structure of blastmycetin E, a new teleocidin-related compound, from Streptoverticillium blastmyceticum |
Structure of blastmycetin E, a new teleocidin-related compound, from Streptoverticillium blastmyceticum |
Tetrahedron Lett., 30/16, 2113-2116 |
Tetrahedron Lett., 30/16, 2113-2116 |
Tetrahedron Lett., 30/16, 2113-2116 |
1989 |
Refereed |
English |
Research paper(scientific journal) |
Disclose to all |
K. Koshimizu* and K. Irie |
K. Koshimizu* and K. Irie |
K. Koshimizu* and K. Irie |
Structure-activity studies in the induction of Epstein-Barr virus by the indole alkaloid tumor promoter teleocidins |
Structure-activity studies in the induction of Epstein-Barr virus by the indole alkaloid tumor promoter teleocidins |
Structure-activity studies in the induction of Epstein-Barr virus by the indole alkaloid tumor promoter teleocidins |
Hokkaido Univ. Med. Lib. Ser., 24, 111-134 |
Hokkaido Univ. Med. Lib. Ser., 24, 111-134 |
Hokkaido Univ. Med. Lib. Ser., 24, 111-134 |
1989 |
Refereed |
English |
Research paper(scientific journal) |
Disclose to all |
N. Hagiwara, K. Irie, A. Funaki, H. Hayashi, M. Arai and K. Koshimizu* |
N. Hagiwara, K. Irie, A. Funaki, H. Hayashi, M. Arai and K. Koshimizu* |
N. Hagiwara, K. Irie, A. Funaki, H. Hayashi, M. Arai and K. Koshimizu* |
Structure and tumor-promoting activity of new teleocidin-related metabolites (blastmycetins) from Streptoverticillium blastmyceticum |
Structure and tumor-promoting activity of new teleocidin-related metabolites (blastmycetins) from Streptoverticillium blastmyceticum |
Structure and tumor-promoting activity of new teleocidin-related metabolites (blastmycetins) from Streptoverticillium blastmyceticum |
Agric. Biol. Chem., 52/3, 641-648 |
Agric. Biol. Chem., 52/3, 641-648 |
Agric. Biol. Chem., 52/3, 641-648 |
1988 |
Refereed |
English |
Research paper(scientific journal) |
Disclose to all |
K. Irie and K. Koshimizu* |
K. Irie and K. Koshimizu* |
K. Irie and K. Koshimizu* |
Structure-activity studies of indole alkaloid tumor promoters |
Structure-activity studies of indole alkaloid tumor promoters |
Structure-activity studies of indole alkaloid tumor promoters |
Mem. Coll. Agric., Kyoto Univ.,132, 1-59 |
Mem. Coll. Agric., Kyoto Univ.,132, 1-59 |
Mem. Coll. Agric., Kyoto Univ.,132, 1-59 |
1988 |
Refereed |
English |
Research paper(scientific journal) |
Disclose to all |
K. Irie, N. Hagiwara, A. Funaki, H. Hayashi, M. Arai, H. Tokuda and K. Koshimizu* |
K. Irie, N. Hagiwara, A. Funaki, H. Hayashi, M. Arai, H. Tokuda and K. Koshimizu* |
K. Irie, N. Hagiwara, A. Funaki, H. Hayashi, M. Arai, H. Tokuda and K. Koshimizu* |
Isolation and biological activities of N13-desmethyl analogues of tumor promoter teleocidin from Streptoverticillium blastmyceticum |
Isolation and biological activities of N13-desmethyl analogues of tumor promoter teleocidin from Streptoverticillium blastmyceticum |
Isolation and biological activities of N13-desmethyl analogues of tumor promoter teleocidin from Streptoverticillium blastmyceticum |
Agric. Biol. Chem., 52/12, 3193-3195 |
Agric. Biol. Chem., 52/12, 3193-3195 |
Agric. Biol. Chem., 52/12, 3193-3195 |
1988 |
Refereed |
English |
Research paper(scientific journal) |
Disclose to all |
Y. Nakagawa*, T. Sotomatsu, K. Irie, K. Kitahara, H. Iwamura and T. Fujita |
Y. Nakagawa*, T. Sotomatsu, K. Irie, K. Kitahara, H. Iwamura and T. Fujita |
Y. Nakagawa*, T. Sotomatsu, K. Irie, K. Kitahara, H. Iwamura and T. Fujita |
Quantitative structure-activity studies of benzoylphenylurea larvicides |
Quantitative structure-activity studies of benzoylphenylurea larvicides |
Quantitative structure-activity studies of benzoylphenylurea larvicides |
Pestic. Biochem. Physiol.,27, 143-155 |
Pestic. Biochem. Physiol.,27, 143-155 |
Pestic. Biochem. Physiol.,27, 143-155 |
1987 |
Refereed |
English |
Research paper(scientific journal) |
Disclose to all |
入江 一浩 |
入江 一浩 |
|
Teleocidin 類の構造活性相関と蛍光標識化 |
Teleocidin 類の構造活性相関と蛍光標識化 |
|
日本農芸化学会誌, 61/7, 830-833 |
日本農芸化学会誌, 61/7, 830-833 |
|
1987 |
Refereed |
Japanese |
Research paper(scientific journal) |
Disclose to all |
K. Irie, N. Hagiwara, T. Kurome, H. Hayashi, M. Arai and K. Koshimizu* |
K. Irie, N. Hagiwara, T. Kurome, H. Hayashi, M. Arai and K. Koshimizu* |
K. Irie, N. Hagiwara, T. Kurome, H. Hayashi, M. Arai and K. Koshimizu* |
New teleocidin-related metabolites from Streptoverticillium blastmycericum producing tumor-promoting indole alkaloids |
New teleocidin-related metabolites from Streptoverticillium blastmycericum producing tumor-promoting indole alkaloids |
New teleocidin-related metabolites from Streptoverticillium blastmycericum producing tumor-promoting indole alkaloids |
Agric. Biol. Chem., 51/1, 285-287 |
Agric. Biol. Chem., 51/1, 285-287 |
Agric. Biol. Chem., 51/1, 285-287 |
1987 |
Refereed |
English |
Research paper(scientific journal) |
Disclose to all |
K. Irie, N. Hagiwara, H. Tokuda and K. Koshimizu* |
K. Irie, N. Hagiwara, H. Tokuda and K. Koshimizu* |
K. Irie, N. Hagiwara, H. Tokuda and K. Koshimizu* |
Structure-activity studies of the indole alkaloid tumor promoter teleocidins |
Structure-activity studies of the indole alkaloid tumor promoter teleocidins |
Structure-activity studies of the indole alkaloid tumor promoter teleocidins |
Carcinogenesis, 8/4, 547-552 |
Carcinogenesis, 8/4, 547-552 |
Carcinogenesis, 8/4, 547-552 |
1987 |
Refereed |
English |
Research paper(scientific journal) |
Disclose to all |
K. Irie, N. Hagiwara, A. Funaki, H. Hayashi, M. Arai and K. Koshimizu* |
K. Irie, N. Hagiwara, A. Funaki, H. Hayashi, M. Arai and K. Koshimizu* |
K. Irie, N. Hagiwara, A. Funaki, H. Hayashi, M. Arai and K. Koshimizu* |
Isolation of blastmycetin D, a possible precursor of teleocidins, from Streptoverticillium blastmyceticum |
Isolation of blastmycetin D, a possible precursor of teleocidins, from Streptoverticillium blastmyceticum |
Isolation of blastmycetin D, a possible precursor of teleocidins, from Streptoverticillium blastmyceticum |
Agric. Biol. Chem., 51/6, 1733-1735 |
Agric. Biol. Chem., 51/6, 1733-1735 |
Agric. Biol. Chem., 51/6, 1733-1735 |
1987 |
Refereed |
English |
Research paper(scientific journal) |
Disclose to all |
K. Irie, N. Hagiwara and K. Koshimizu* |
K. Irie, N. Hagiwara and K. Koshimizu* |
K. Irie, N. Hagiwara and K. Koshimizu* |
Synthesis of a biologically active fluorescent indolactam derivative; a method of preparing new probes for receptor analysis of tumor promoters |
Synthesis of a biologically active fluorescent indolactam derivative; a method of preparing new probes for receptor analysis of tumor promoters |
Synthesis of a biologically active fluorescent indolactam derivative; a method of preparing new probes for receptor analysis of tumor promoters |
Tetrahedron Lett., 28/28, 3267-3270 |
Tetrahedron Lett., 28/28, 3267-3270 |
Tetrahedron Lett., 28/28, 3267-3270 |
1987 |
Refereed |
English |
Research paper(scientific journal) |
Disclose to all |
N. Hagiwara, K. Irie, H. Tokuda and K. Koshimizu* |
N. Hagiwara, K. Irie, H. Tokuda and K. Koshimizu* |
N. Hagiwara, K. Irie, H. Tokuda and K. Koshimizu* |
The metabolism of indole alkaloid tumor promoter, (-)-indolactam V, which has the fundamental structure of teleocidins, by rat liver microsomes |
The metabolism of indole alkaloid tumor promoter, (-)-indolactam V, which has the fundamental structure of teleocidins, by rat liver microsomes |
The metabolism of indole alkaloid tumor promoter, (-)-indolactam V, which has the fundamental structure of teleocidins, by rat liver microsomes |
Carcinogenesis, 8/7, 963-965 |
Carcinogenesis, 8/7, 963-965 |
Carcinogenesis, 8/7, 963-965 |
1987 |
Refereed |
English |
Research paper(scientific journal) |
Disclose to all |
K. Irie, N. Hagiwara and K. Koshimizu* |
K. Irie, N. Hagiwara and K. Koshimizu* |
K. Irie, N. Hagiwara and K. Koshimizu* |
New probes for receptor analysis of tumor promoters synthesis of fluorescent derivatives of (-)-indolactam V, the basic ring-structure of teleocidins |
New probes for receptor analysis of tumor promoters synthesis of fluorescent derivatives of (-)-indolactam V, the basic ring-structure of teleocidins |
New probes for receptor analysis of tumor promoters synthesis of fluorescent derivatives of (-)-indolactam V, the basic ring-structure of teleocidins |
Tetrahedron, 43/22, 5251-5260 |
Tetrahedron, 43/22, 5251-5260 |
Tetrahedron, 43/22, 5251-5260 |
1987 |
Refereed |
English |
Research paper(scientific journal) |
Disclose to all |
K. Irie, H. Hayashi, M. Arai and K. Koshimizu* |
K. Irie, H. Hayashi, M. Arai and K. Koshimizu* |
K. Irie, H. Hayashi, M. Arai and K. Koshimizu* |
Substitution reaction on the indole ring of (-)-indolactam V, the fundamental structure of teleocidins |
Substitution reaction on the indole ring of (-)-indolactam V, the fundamental structure of teleocidins |
Substitution reaction on the indole ring of (-)-indolactam V, the fundamental structure of teleocidins |
Agric. Biol. Chem., 50/10, 2679-2680 |
Agric. Biol. Chem., 50/10, 2679-2680 |
Agric. Biol. Chem., 50/10, 2679-2680 |
1986 |
Refereed |
English |
Research paper(scientific journal) |
Disclose to all |
入江 一浩*, 小清水 弘一 |
入江 一浩*, 小清水 弘一 |
|
微生物の生産する発癌プロモーター |
微生物の生産する発癌プロモーター |
|
日本放線菌学会誌,49, 3-9 |
日本放線菌学会誌,49, 3-9 |
|
1986 |
Refereed |
Japanese |
Research paper(scientific journal) |
Disclose to all |
K. Irie, N. Hagiwara, K. Koshimizu*, H. Hayashi, S. Murao, H. Tokuda and Y. Ito |
K. Irie, N. Hagiwara, K. Koshimizu*, H. Hayashi, S. Murao, H. Tokuda and Y. Ito |
K. Irie, N. Hagiwara, K. Koshimizu*, H. Hayashi, S. Murao, H. Tokuda and Y. Ito |
Isolation and the Epstein-Barr virus early antigen inducing activity of olivoretins from Streptoverticillium blastmyceticum |
Isolation and the Epstein-Barr virus early antigen inducing activity of olivoretins from Streptoverticillium blastmyceticum |
Isolation and the Epstein-Barr virus early antigen inducing activity of olivoretins from Streptoverticillium blastmyceticum |
Agric. Biol. Chem., 49/1, 221-223 |
Agric. Biol. Chem., 49/1, 221-223 |
Agric. Biol. Chem., 49/1, 221-223 |
1985 |
Refereed |
English |
Research paper(scientific journal) |
Disclose to all |
K. Irie*, N. Hagiwara, K. Koshimizu, H. Hayashi, S. Murao and Y. Ito |
K. Irie*, N. Hagiwara, K. Koshimizu, H. Hayashi, S. Murao and Y. Ito |
K. Irie*, N. Hagiwara, K. Koshimizu, H. Hayashi, S. Murao and Y. Ito |
Identification of the microorganism which produces Epstein-Barr virus early antigen-inducing indole alkaloids |
Identification of the microorganism which produces Epstein-Barr virus early antigen-inducing indole alkaloids |
Identification of the microorganism which produces Epstein-Barr virus early antigen-inducing indole alkaloids |
Agric. Biol. Chem., 49/3, 845-847 |
Agric. Biol. Chem., 49/3, 845-847 |
Agric. Biol. Chem., 49/3, 845-847 |
1985 |
Refereed |
English |
Research paper(scientific journal) |
Disclose to all |
H. Fujiki*, M. Suganuma, H. Hakii, M. Nakayasu, Y. Endo, K. Shodo, K. Irie, K. Koshimizu and T. Sugimura, M. J. A. |
H. Fujiki*, M. Suganuma, H. Hakii, M. Nakayasu, Y. Endo, K. Shodo, K. Irie, K. Koshimizu and T. Sugimura, M. J. A. |
H. Fujiki*, M. Suganuma, H. Hakii, M. Nakayasu, Y. Endo, K. Shodo, K. Irie, K. Koshimizu and T. Sugimura, M. J. A. |
Tumor promoting activities of new synthetic analogues of teleocidin |
Tumor promoting activities of new synthetic analogues of teleocidin |
Tumor promoting activities of new synthetic analogues of teleocidin |
Proc. Japan Acad., 61/1, 45-47 |
Proc. Japan Acad., 61/1, 45-47 |
Proc. Japan Acad., 61/1, 45-47 |
1985 |
Refereed |
English |
Research paper(scientific journal) |
Disclose to all |
K. Irie, N. Hagiwara, K. Koshimizu*, H. Tokuda, Y. Ito, H. Hayashi, and S. Murao |
K. Irie, N. Hagiwara, K. Koshimizu*, H. Tokuda, Y. Ito, H. Hayashi, and S. Murao |
K. Irie, N. Hagiwara, K. Koshimizu*, H. Tokuda, Y. Ito, H. Hayashi, and S. Murao |
Epstein-Barr Virus Early Antigen Inducing Activity of 14-O-Derivatives of (-)-Indolactam V |
Epstein-Barr Virus Early Antigen Inducing Activity of 14-O-Derivatives of (-)-Indolactam V |
Epstein-Barr Virus Early Antigen Inducing Activity of 14-O-Derivatives of (-)-Indolactam V |
Agric. Biol. Chem., 49/5, 1441-1446 |
Agric. Biol. Chem., 49/5, 1441-1446 |
Agric. Biol. Chem., 49/5, 1441-1446 |
1985 |
Refereed |
English |
Research paper(scientific journal) |
Disclose to all |
N. Hagiwara, K. Irie, K. Koshimizu*, H. Hayashi, S. Murao, H. Tokuda and Y. Ito |
N. Hagiwara, K. Irie, K. Koshimizu*, H. Hayashi, S. Murao, H. Tokuda and Y. Ito |
N. Hagiwara, K. Irie, K. Koshimizu*, H. Hayashi, S. Murao, H. Tokuda and Y. Ito |
New teleocidin metabolites from Streptoverticillium blastmyceticum |
New teleocidin metabolites from Streptoverticillium blastmyceticum |
New teleocidin metabolites from Streptoverticillium blastmyceticum |
Agric. Biol. Chem., 49/8, 2529-2530 |
Agric. Biol. Chem., 49/8, 2529-2530 |
Agric. Biol. Chem., 49/8, 2529-2530 |
1985 |
Refereed |
English |
Research paper(scientific journal) |
Disclose to all |
K. Irie, H. Tokuda, N. Hagiwara, K. Koshimizu*, H. Hayashi, S. Murao and Y. Ito |
K. Irie, H. Tokuda, N. Hagiwara, K. Koshimizu*, H. Hayashi, S. Murao and Y. Ito |
K. Irie, H. Tokuda, N. Hagiwara, K. Koshimizu*, H. Hayashi, S. Murao and Y. Ito |
Structure-activity relationship in the induction of Epstein-Barr virus by teleocidin derivatives |
Structure-activity relationship in the induction of Epstein-Barr virus by teleocidin derivatives |
Structure-activity relationship in the induction of Epstein-Barr virus by teleocidin derivatives |
Int. J. Cancer, 36/4, 485-488 |
Int. J. Cancer, 36/4, 485-488 |
Int. J. Cancer, 36/4, 485-488 |
1985 |
Refereed |
English |
Research paper(scientific journal) |
Disclose to all |
K. Irie, M. Hirota, N. Hagiwara, K. Koshimizu*, H. Hayashi, S. Murao, H. Tokuda, and Y. Ito |
K. Irie, M. Hirota, N. Hagiwara, K. Koshimizu*, H. Hayashi, S. Murao, H. Tokuda, and Y. Ito |
K. Irie, M. Hirota, N. Hagiwara, K. Koshimizu*, H. Hayashi, S. Murao, H. Tokuda, and Y. Ito |
The Epstein-Barr virus early antigen inducing indole alkaloids, (-)-indolactam V and its related compounds produced by actinomycetes |
The Epstein-Barr virus early antigen inducing indole alkaloids, (-)-indolactam V and its related compounds produced by actinomycetes |
The Epstein-Barr virus early antigen inducing indole alkaloids, (-)-indolactam V and its related compounds produced by actinomycetes |
Agric. Biol. Chem., 48/5, 1269-1274 |
Agric. Biol. Chem., 48/5, 1269-1274 |
Agric. Biol. Chem., 48/5, 1269-1274 |
1984 |
Refereed |
English |
Research paper(scientific journal) |
Disclose to all |