三野 享史

Last Update: 2020/07/06 10:09:18

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Name(Kanji/Kana/Abecedarium Latinum)
三野 享史/ミノ タカシ/Mino, Takashi
Primary Affiliation(Org1/Job title)
Graduate Schools Medicine/Assistant Professor
Affiliated programs (koza)
Org1 Job title
Graduate Schools Medicine Assistant Professor
Graduate Schools Medicine Assistant Professor
Faculty
Org1 Job title
医学部
Academic Degree
Field(Japanese) Field(English) University(Japanese) University(English) Method
修士(工学) Master of Engineering 京都大学 Kyoto University
博士(工学) Ph.D. in Engineering 京都大学 Kyoto University
Personal Profile
(Japanese)
自然免疫による炎症の制御メカニズムについて研究を行っている。特に,炎症の転写後調節のメカニズムについて研究を進めている。
(English)
I am studying the regulatory mechanisms of innate immunity. Particularly, I am interested in the posttranscriptional regulation of innate immune system.
researchmap URL
https://researchmap.jp/7000009274
Research Topics
(Japanese)
自然免疫における転写後調節の解明
(English)
Post-transcriptional Regulation of Innate Immune System
Overview of the research
(Japanese)
病原体が体内に侵入すると最初に自然免疫担当細胞が病原体を検出し,炎症性サイトカイン産生を介して自然免疫応答である炎症が誘導される。これまで,サイトカイン産生(サイトカインタンパク質の翻訳)はそのmRNAの転写により調節されると考えられてきた。しかし,転写されたmRNAの安定性やタンパク質への翻訳は転写後調節と呼ばれる制御機構により細胞内で厳密に制御されており,転写後調節は自然免疫応答である炎症の開始と抑制(終焉)にも重要な役割を担っていることが明らかになってきた。我々は,これまで転写制御(mRNA産生の制御)と比較して未知の領域である,自然免疫の転写後調節について研究している。
(English)
Cytokines are critical mediators of inflammation and host defense. Cytokine production is regulated during transcription and post-transcription. Post-transcriptional regulation modifies mRNA stability and translation, allowing for the rapid and flexible control of gene expression, which is important for coordinating the initiation and resolution of inflammation. We investigate mechanisms of post-transcriptional regulation that regulate inflammation.
Fields of research (key words)
Key words(Japanese) Key words(English)
自然免疫 Innate immune system
転写後調節 Post-transcriptional regulation
サイトカインmRNA Cytokine mRNA
Regnase-1 (regulatory RNase-1), Zc3h12a, Mcpip1 Regnase-1 (regulatory RNase-1), Zc3h12a, Mcpip1
Published Papers
Author Author(Japanese) Author(English) Title Title(Japanese) Title(English) Bibliography Bibliography(Japanese) Bibliography(English) Publication date Refereed paper Language Publishing type Disclose
Takashi Mino, Noriki Iwai, Masayuki Endo, Kentaro Inoue, Kotaro Akaki, Fabian Hia, Takuya Uehata, Tomoko Emura, Kumi Hidaka, Yutaka Suzuki, Daron M Standley, Mariko Okada-Hatakeyama, Shigeo Ohno, Hiroshi Sugiyama, Akio Yamashita, Osamu Takeuchi Takashi Mino, Noriki Iwai, Masayuki Endo, Kentaro Inoue, Kotaro Akaki, Fabian Hia, Takuya Uehata, Tomoko Emura, Kumi Hidaka, Yutaka Suzuki, Daron M Standley, Mariko Okada-Hatakeyama, Shigeo Ohno, Hiroshi Sugiyama, Akio Yamashita, Osamu Takeuchi Takashi Mino, Noriki Iwai, Masayuki Endo, Kentaro Inoue, Kotaro Akaki, Fabian Hia, Takuya Uehata, Tomoko Emura, Kumi Hidaka, Yutaka Suzuki, Daron M Standley, Mariko Okada-Hatakeyama, Shigeo Ohno, Hiroshi Sugiyama, Akio Yamashita, Osamu Takeuchi Translation-dependent unwinding of stem–loops by UPF1 licenses Regnase-1 to degrade inflammatory mRNAs Translation-dependent unwinding of stem–loops by UPF1 licenses Regnase-1 to degrade inflammatory mRNAs Translation-dependent unwinding of stem–loops by UPF1 licenses Regnase-1 to degrade inflammatory mRNAs Nucleic Acids Research Nucleic Acids Research Nucleic Acids Research 2019/07/22 Refereed English Research paper(scientific journal) Disclose to all
Yamasoba, D, Sato, K, Ichinose, T, Imamura, T, Koepke, L, Joas, S, Reith, E, Hotter, D, Misawa, N, Akaki, K, Uehata, T, Mino, T, Miyamoto, S, Noda, T, Yamashita, A, Standley, D.M, Kirchhoff, F, Sauter, D, Koyanagi, Y, Takeuchi, O Yamasoba, D, Sato, K, Ichinose, T, Imamura, T, Koepke, L, Joas, S, Reith, E, Hotter, D, Misawa, N, Akaki, K, Uehata, T, Mino, T, Miyamoto, S, Noda, T, Yamashita, A, Standley, D.M, Kirchhoff, F, Sauter, D, Koyanagi, Y, Takeuchi, O N4BP1 restricts HIV-1 and its inactivation by MALT1 promotes viral reactivation. N4BP1 restricts HIV-1 and its inactivation by MALT1 promotes viral reactivation. N4BP1 restricts HIV-1 and its inactivation by MALT1 promotes viral reactivation. Nature Microbiology Nature Microbiology Nature Microbiology 2019/05 Refereed English Research paper(scientific journal) Disclose to all
Yoshinari Nakatsuka, Alexis Vandenbon, Takashi Mino, Masanori Yoshinaga, Takuya Uehata, Xiaotong Cui, Ayuko Sato, Tohru Tsujimura, Yutaka Suzuki, Atsuyasu Sato, Tomohiro Handa, Kazuo Chin, Teiji Sawa, Toyohiro Hirai, Osamu Takeuchi Yoshinari Nakatsuka, Alexis Vandenbon, Takashi Mino, Masanori Yoshinaga, Takuya Uehata, Xiaotong Cui, Ayuko Sato, Tohru Tsujimura, Yutaka Suzuki, Atsuyasu Sato, Tomohiro Handa, Kazuo Chin, Teiji Sawa, Toyohiro Hirai, Osamu Takeuchi Yoshinari Nakatsuka, Alexis Vandenbon, Takashi Mino, Masanori Yoshinaga, Takuya Uehata, Xiaotong Cui, Ayuko Sato, Tohru Tsujimura, Yutaka Suzuki, Atsuyasu Sato, Tomohiro Handa, Kazuo Chin, Teiji Sawa, Toyohiro Hirai, Osamu Takeuchi Pulmonary Regnase-1 orchestrates the interplay of epithelium and adaptive immune systems to protect against pneumonia. Pulmonary Regnase-1 orchestrates the interplay of epithelium and adaptive immune systems to protect against pneumonia. Pulmonary Regnase-1 orchestrates the interplay of epithelium and adaptive immune systems to protect against pneumonia. Mucosal immunology, 11, 4, 1203-1218 Mucosal immunology, 11, 4, 1203-1218 Mucosal immunology, 11, 4, 1203-1218 2018/07 Refereed English Research paper(scientific journal) Disclose to all
Mino, T, Takeuchi, O Mino, T, Takeuchi, O Mino, T, Takeuchi, O Post-transcriptional regulation of immune responses by RNA binding proteins. Post-transcriptional regulation of immune responses by RNA binding proteins. Post-transcriptional regulation of immune responses by RNA binding proteins. Proc. Jpn. Acad. Ser. B Phys. Biol. Sci., 94, 6, 248-258 Proc. Jpn. Acad. Ser. B Phys. Biol. Sci., 94, 6, 248-258 Proc. Jpn. Acad. Ser. B Phys. Biol. Sci., 94, 6, 248-258 2018/06 Refereed English Research paper(bulletin of university, research institution) Disclose to all
Takashi Mino, Osamu Takeuchi Takashi Mino, Osamu Takeuchi Takashi Mino, Osamu Takeuchi NSD3 keeps IRF3 active NSD3 keeps IRF3 active NSD3 keeps IRF3 active JOURNAL OF EXPERIMENTAL MEDICINE, 214, 12, 3475-3476 JOURNAL OF EXPERIMENTAL MEDICINE, 214, 12, 3475-3476 JOURNAL OF EXPERIMENTAL MEDICINE, 214, 12, 3475-3476 2017/12 Refereed English Research paper(scientific journal) Disclose to all
Xiaotong Cui, Takashi Mino, Masanori Yoshinaga, Yoshinari Nakatsuka, Fabian Hia, Daichi Yamasoba, Tohru Tsujimura, Keizo Tomonaga, Yutaka Suzuki, Takuya Uehata, Osamu Takeuchi Xiaotong Cui, Takashi Mino, Masanori Yoshinaga, Yoshinari Nakatsuka, Fabian Hia, Daichi Yamasoba, Tohru Tsujimura, Keizo Tomonaga, Yutaka Suzuki, Takuya Uehata, Osamu Takeuchi Xiaotong Cui, Takashi Mino, Masanori Yoshinaga, Yoshinari Nakatsuka, Fabian Hia, Daichi Yamasoba, Tohru Tsujimura, Keizo Tomonaga, Yutaka Suzuki, Takuya Uehata, Osamu Takeuchi Regnase-1 and Roquin Nonredundantly Regulate Th1 Differentiation Causing Cardiac Inflammation and Fibrosis Regnase-1 and Roquin Nonredundantly Regulate Th1 Differentiation Causing Cardiac Inflammation and Fibrosis Regnase-1 and Roquin Nonredundantly Regulate Th1 Differentiation Causing Cardiac Inflammation and Fibrosis JOURNAL OF IMMUNOLOGY, 199, 12, 4066-4077 JOURNAL OF IMMUNOLOGY, 199, 12, 4066-4077 JOURNAL OF IMMUNOLOGY, 199, 12, 4066-4077 2017/12 Refereed English Research paper(scientific journal) Disclose to all
Masanori Yoshinaga, Yoshinari Nakatsuka, Alexis Vandenbon, Daisuke Ori, Takuya Uehata, Tohru Tsujimura, Yutaka Suzuki, Takashi Mino, Osamu Takeuchi Masanori Yoshinaga, Yoshinari Nakatsuka, Alexis Vandenbon, Daisuke Ori, Takuya Uehata, Tohru Tsujimura, Yutaka Suzuki, Takashi Mino, Osamu Takeuchi Masanori Yoshinaga, Yoshinari Nakatsuka, Alexis Vandenbon, Daisuke Ori, Takuya Uehata, Tohru Tsujimura, Yutaka Suzuki, Takashi Mino, Osamu Takeuchi Regnase-1 Maintains Iron Homeostasis via the Degradation of Transferrin Receptor 1 and Prolyl-Hydroxylase- Domain-Containing Protein 3 mRNAs Regnase-1 Maintains Iron Homeostasis via the Degradation of Transferrin Receptor 1 and Prolyl-Hydroxylase- Domain-Containing Protein 3 mRNAs Regnase-1 Maintains Iron Homeostasis via the Degradation of Transferrin Receptor 1 and Prolyl-Hydroxylase- Domain-Containing Protein 3 mRNAs CELL REPORTS, 19, 8, 1614-1630 CELL REPORTS, 19, 8, 1614-1630 CELL REPORTS, 19, 8, 1614-1630 2017/05 Refereed English Research paper(scientific journal) Disclose to all
Mino T, Takeuchi O Mino T, Takeuchi O Mino T, Takeuchi O [Post-transcriptional regulation of inflammatory mRNA by Regnase-1 and Roquin]. [Post-transcriptional regulation of inflammatory mRNA by Regnase-1 and Roquin]. [Post-transcriptional regulation of inflammatory mRNA by Regnase-1 and Roquin]. Nihon yakurigaku zasshi. Folia pharmacologica Japonica, 147, 6, 351-356 Nihon yakurigaku zasshi. Folia pharmacologica Japonica, 147, 6, 351-356 Nihon yakurigaku zasshi. Folia pharmacologica Japonica, 147, 6, 351-356 2016/06 Refereed Disclose to all
Sarang Tartey, Kazufumi Matsushita, Tomoko Imamura, Atsuko Wakabayashi, Daisuke Ori, Takashi Mino, Osamu Takeuchi Sarang Tartey, Kazufumi Matsushita, Tomoko Imamura, Atsuko Wakabayashi, Daisuke Ori, Takashi Mino, Osamu Takeuchi Sarang Tartey, Kazufumi Matsushita, Tomoko Imamura, Atsuko Wakabayashi, Daisuke Ori, Takashi Mino, Osamu Takeuchi Essential Function for the Nuclear Protein Akirin2 in B Cell Activation and Humoral Immune Responses Essential Function for the Nuclear Protein Akirin2 in B Cell Activation and Humoral Immune Responses Essential Function for the Nuclear Protein Akirin2 in B Cell Activation and Humoral Immune Responses JOURNAL OF IMMUNOLOGY, 195, 2, 519-527 JOURNAL OF IMMUNOLOGY, 195, 2, 519-527 JOURNAL OF IMMUNOLOGY, 195, 2, 519-527 2015/07 Refereed English Research paper(scientific journal) Disclose to all
Takashi Mino, Osamu Takeuchi Takashi Mino, Osamu Takeuchi Takashi Mino, Osamu Takeuchi Regnase-1 and Roquin regulate inflammatory mRNAs Regnase-1 and Roquin regulate inflammatory mRNAs Regnase-1 and Roquin regulate inflammatory mRNAs ONCOTARGET, 6, 20, 17869-17870 ONCOTARGET, 6, 20, 17869-17870 ONCOTARGET, 6, 20, 17869-17870 2015/07 Refereed English Research paper(scientific journal) Disclose to all
Takashi Mino, Yasuhiro Murakawa, Akira Fukao, Alexis Vandenbon, Hans-Hermann Wessels, Daisuke Ori, Takuya Uehata, Sarang Tartey, Shizuo Akira, Yutaka Suzuki, Carola G. Vinuesa, Uwe Ohler, Daron M. Standley, Markus Landthaler, Toshinobu Fujiwara, Osamu Takeuchi Takashi Mino, Yasuhiro Murakawa, Akira Fukao, Alexis Vandenbon, Hans-Hermann Wessels, Daisuke Ori, Takuya Uehata, Sarang Tartey, Shizuo Akira, Yutaka Suzuki, Carola G. Vinuesa, Uwe Ohler, Daron M. Standley, Markus Landthaler, Toshinobu Fujiwara, Osamu Takeuchi Takashi Mino, Yasuhiro Murakawa, Akira Fukao, Alexis Vandenbon, Hans-Hermann Wessels, Daisuke Ori, Takuya Uehata, Sarang Tartey, Shizuo Akira, Yutaka Suzuki, Carola G. Vinuesa, Uwe Ohler, Daron M. Standley, Markus Landthaler, Toshinobu Fujiwara, Osamu Takeuchi Regnase-1 and Roquin Regulate a Common Element in Inflammatory mRNAs by Spatiotemporally Distinct Mechanisms Regnase-1 and Roquin Regulate a Common Element in Inflammatory mRNAs by Spatiotemporally Distinct Mechanisms Regnase-1 and Roquin Regulate a Common Element in Inflammatory mRNAs by Spatiotemporally Distinct Mechanisms CELL, 161, 5, 1058-1073 CELL, 161, 5, 1058-1073 CELL, 161, 5, 1058-1073 2015/05 Refereed English Research paper(scientific journal) Disclose to all
Sarang Tartey, Kazufumi Matsushita, Alexis Vandenbon, Daisuke Ori, Tomoko Imamura, Takashi Mino, Daron M. Standley, Jules A. Hoffmann, Jean-Marc Reichhart, Shizuo Akira, Osamu Takeuchi Tartey S, Matsushita K, Vandenbon A, Ori D, Imamura T, Mino T, Standley DM, Hoffmann JA, Reichhart JM, Akira S, Takeuchi O Sarang Tartey, Kazufumi Matsushita, Alexis Vandenbon, Daisuke Ori, Tomoko Imamura, Takashi Mino, Daron M. Standley, Jules A. Hoffmann, Jean-Marc Reichhart, Shizuo Akira, Osamu Takeuchi Akirin2 is critical for inducing inflammatory genes by bridging I kappa B-zeta and the SWI/SNF complex Akirin2 is critical for inducing inflammatory genes by bridging IκB-ζ and the SWI/SNF complex. Akirin2 is critical for inducing inflammatory genes by bridging I kappa B-zeta and the SWI/SNF complex EMBO JOURNAL, 33, 20, 2332-2348 The EMBO journal, 33, 20, 2332-2348 EMBO JOURNAL, 33, 20, 2332-2348 2014/10 Refereed English Research paper(scientific journal) Disclose to all
Takashi Mino, Tomoaki Mori, Yasuhiro Aoyama, Takashi Sera Takashi Mino, Tomoaki Mori, Yasuhiro Aoyama, Takashi Sera Takashi Mino, Tomoaki Mori, Yasuhiro Aoyama, Takashi Sera Inhibition of DNA Replication of Human Papillomavirus by Using Zinc Finger-Single-Chain FokI Dimer Hybrid Inhibition of DNA Replication of Human Papillomavirus by Using Zinc Finger-Single-Chain FokI Dimer Hybrid Inhibition of DNA Replication of Human Papillomavirus by Using Zinc Finger-Single-Chain FokI Dimer Hybrid MOLECULAR BIOTECHNOLOGY, 56, 8, 731-737 MOLECULAR BIOTECHNOLOGY, 56, 8, 731-737 MOLECULAR BIOTECHNOLOGY, 56, 8, 731-737 2014/08 Refereed English Research paper(scientific journal) Disclose to all
Masahiro Fukasaka, Daisuke Ori, Tatsukata Kawagoe, Satoshi Uematsu, Kenta Maruyama, Toshihiko Okazaki, Tatsuya Kozaki, Tomoko Imamura, Sarang Tartey, Takashi Mino, Takashi Satoh, Shizuo Akira, Osamu Takeuchi Masahiro Fukasaka, Daisuke Ori, Tatsukata Kawagoe, Satoshi Uematsu, Kenta Maruyama, Toshihiko Okazaki, Tatsuya Kozaki, Tomoko Imamura, Sarang Tartey, Takashi Mino, Takashi Satoh, Shizuo Akira, Osamu Takeuchi Masahiro Fukasaka, Daisuke Ori, Tatsukata Kawagoe, Satoshi Uematsu, Kenta Maruyama, Toshihiko Okazaki, Tatsuya Kozaki, Tomoko Imamura, Sarang Tartey, Takashi Mino, Takashi Satoh, Shizuo Akira, Osamu Takeuchi Critical Role of AZI2 in GM-CSF-Induced Dendritic Cell Differentiation Critical Role of AZI2 in GM-CSF-Induced Dendritic Cell Differentiation Critical Role of AZI2 in GM-CSF-Induced Dendritic Cell Differentiation JOURNAL OF IMMUNOLOGY, 190, 11, 5702-5711 JOURNAL OF IMMUNOLOGY, 190, 11, 5702-5711 JOURNAL OF IMMUNOLOGY, 190, 11, 5702-5711 2013/06 Refereed English Research paper(scientific journal) Disclose to all
Masuda K, Ripley B, Nishimura R, Mino T, Takeuchi O, Shioi G, Kiyonari H, Kishimoto T Masuda K, Ripley B, Nishimura R, Mino T, Takeuchi O, Shioi G, Kiyonari H, Kishimoto T Masuda K, Ripley B, Nishimura R, Mino T, Takeuchi O, Shioi G, Kiyonari H, Kishimoto T Arid5a controls IL-6 mRNA stability, which contributes to elevation of IL-6 level in vivo. Arid5a controls IL-6 mRNA stability, which contributes to elevation of IL-6 level in vivo. Arid5a controls IL-6 mRNA stability, which contributes to elevation of IL-6 level in vivo. Proceedings of the National Academy of Sciences of the United States of America, 110, 23, 9409-9414 Proceedings of the National Academy of Sciences of the United States of America, 110, 23, 9409-9414 Proceedings of the National Academy of Sciences of the United States of America, 110, 23, 9409-9414 2013/06 Refereed English Research paper(scientific journal) Disclose to all
Takuya Uehata, Hidenori Iwasaki, Alexis Vandenbon, Kazufumi Matsushita, Eduardo Hernandez-Cuellar, Kanako Kuniyoshi, Takashi Satoh, Takashi Mino, Yutaka Suzuki, Daron M Standley, Tohru Tsujimura, Hiromi Rakugi, Yoshitaka Isaka, Osamu Takeuchi, Shizuo Akira Takuya Uehata, Hidenori Iwasaki, Alexis Vandenbon, Kazufumi Matsushita, Eduardo Hernandez-Cuellar, Kanako Kuniyoshi, Takashi Satoh, Takashi Mino, Yutaka Suzuki, Daron M Standley, Tohru Tsujimura, Hiromi Rakugi, Yoshitaka Isaka, Osamu Takeuchi, Shizuo Akira Takuya Uehata, Hidenori Iwasaki, Alexis Vandenbon, Kazufumi Matsushita, Eduardo Hernandez-Cuellar, Kanako Kuniyoshi, Takashi Satoh, Takashi Mino, Yutaka Suzuki, Daron M Standley, Tohru Tsujimura, Hiromi Rakugi, Yoshitaka Isaka, Osamu Takeuchi, Shizuo Akira Malt1-induced cleavage of regnase-1 in CD4(+) helper T cells regulates immune activation. Malt1-induced cleavage of regnase-1 in CD4(+) helper T cells regulates immune activation. Malt1-induced cleavage of regnase-1 in CD4(+) helper T cells regulates immune activation. Cell, 153, 5, 1036-49 Cell, 153, 5, 1036-49 Cell, 153, 5, 1036-49 2013/05/23 Refereed English Research paper(scientific journal) Disclose to all
Daisuke Ori, Hiroki Kato, Hideki Sanjo, Sarang Tartey, Takashi Mino, Shizuo Akira, Osamu Takeuchi Daisuke Ori, Hiroki Kato, Hideki Sanjo, Sarang Tartey, Takashi Mino, Shizuo Akira, Osamu Takeuchi Daisuke Ori, Hiroki Kato, Hideki Sanjo, Sarang Tartey, Takashi Mino, Shizuo Akira, Osamu Takeuchi Essential Roles of K63-Linked Polyubiquitin-Binding Proteins TAB2 and TAB3 in B Cell Activation via MAPKs Essential Roles of K63-Linked Polyubiquitin-Binding Proteins TAB2 and TAB3 in B Cell Activation via MAPKs Essential Roles of K63-Linked Polyubiquitin-Binding Proteins TAB2 and TAB3 in B Cell Activation via MAPKs JOURNAL OF IMMUNOLOGY, 190, 8, 4037-4045 JOURNAL OF IMMUNOLOGY, 190, 8, 4037-4045 JOURNAL OF IMMUNOLOGY, 190, 8, 4037-4045 2013/04 Refereed English Research paper(scientific journal) Disclose to all
Takashi Mino, Tomoaki Mori, Yasuhiro Aoyama, Takashi Sera Takashi Mino, Tomoaki Mori, Yasuhiro Aoyama, Takashi Sera Takashi Mino, Tomoaki Mori, Yasuhiro Aoyama, Takashi Sera Gene- and Protein-Delivered Zinc Finger-Staphylococcal Nuclease Hybrid for Inhibition of DNA Replication of Human Papillomavirus Gene- and Protein-Delivered Zinc Finger-Staphylococcal Nuclease Hybrid for Inhibition of DNA Replication of Human Papillomavirus Gene- and Protein-Delivered Zinc Finger-Staphylococcal Nuclease Hybrid for Inhibition of DNA Replication of Human Papillomavirus PLOS ONE, 8, 2, e56633 PLOS ONE, 8, 2, e56633 PLOS ONE, 8, 2, e56633 2013/02 Refereed English Research paper(scientific journal) Disclose to all
Takashi Mino, Osamu Takeuchi Takashi Mino, Osamu Takeuchi Takashi Mino, Osamu Takeuchi Post-transcriptional regulation of cytokine mRNA controls the initiation and resolution of inflammation Post-transcriptional regulation of cytokine mRNA controls the initiation and resolution of inflammation Post-transcriptional regulation of cytokine mRNA controls the initiation and resolution of inflammation BIOTECHNOLOGY AND GENETIC ENGINEERING REVIEWS, VOL 29, ISSUE1, 29, 1, 49-60 BIOTECHNOLOGY AND GENETIC ENGINEERING REVIEWS, VOL 29, ISSUE1, 29, 1, 49-60 BIOTECHNOLOGY AND GENETIC ENGINEERING REVIEWS, VOL 29, ISSUE1, 29, 1, 49-60 2013 Refereed English Disclose to all
三野享史, 竹内理 三野享史, 竹内理 シグナル 自然免疫における転写後調節 シグナル 自然免疫における転写後調節 医学のあゆみ, 243, 1, 57-62 医学のあゆみ, 243, 1, 57-62 , 243, 1, 57-62 2012/10/06 Refereed Japanese Disclose to all
Ping-Hui Tseng, Atsushi Matsuzawa, Weizhou Zhang, Takashi Mino, Dario A. A. Vignali, Michael Karin Ping-Hui Tseng, Atsushi Matsuzawa, Weizhou Zhang, Takashi Mino, Dario A. A. Vignali, Michael Karin Ping-Hui Tseng, Atsushi Matsuzawa, Weizhou Zhang, Takashi Mino, Dario A. A. Vignali, Michael Karin Different modes of ubiquitination of the adaptor TRAF3 selectively activate the expression of type I interferons and proinflammatory cytokines Different modes of ubiquitination of the adaptor TRAF3 selectively activate the expression of type I interferons and proinflammatory cytokines Different modes of ubiquitination of the adaptor TRAF3 selectively activate the expression of type I interferons and proinflammatory cytokines NATURE IMMUNOLOGY, 11, 1, 70-1819 NATURE IMMUNOLOGY, 11, 1, 70-1819 NATURE IMMUNOLOGY, 11, 1, 70-1819 2010/01 Refereed English Research paper(scientific journal) Disclose to all
Takashi Mino, Yasuhiro Aoyama, Takashi Sera Takashi Mino, Yasuhiro Aoyama, Takashi Sera Takashi Mino, Yasuhiro Aoyama, Takashi Sera Efficient double-stranded DNA cleavage by artificial zinc-finger nucleases composed of one zinc-finger protein and a single-chain FokI dimer Efficient double-stranded DNA cleavage by artificial zinc-finger nucleases composed of one zinc-finger protein and a single-chain FokI dimer Efficient double-stranded DNA cleavage by artificial zinc-finger nucleases composed of one zinc-finger protein and a single-chain FokI dimer JOURNAL OF BIOTECHNOLOGY, 140, 3-4, 156-161 JOURNAL OF BIOTECHNOLOGY, 140, 3-4, 156-161 JOURNAL OF BIOTECHNOLOGY, 140, 3-4, 156-161 2009/03 Refereed English Research paper(scientific journal) Disclose to all
Takashi Mino, Tomoaki Mori, Yasuhiro Aoyama, Takashi Sera Takashi Mino, Tomoaki Mori, Yasuhiro Aoyama, Takashi Sera Takashi Mino, Tomoaki Mori, Yasuhiro Aoyama, Takashi Sera Cell-permeable artificial zinc-finger proteins as potent antiviral drugs for human papillomaviruses Cell-permeable artificial zinc-finger proteins as potent antiviral drugs for human papillomaviruses Cell-permeable artificial zinc-finger proteins as potent antiviral drugs for human papillomaviruses ARCHIVES OF VIROLOGY, 153, 7, 1291-1298 ARCHIVES OF VIROLOGY, 153, 7, 1291-1298 ARCHIVES OF VIROLOGY, 153, 7, 1291-1298 2008/07 Refereed English Research paper(scientific journal) Disclose to all
T. Mino, T. Mori, Y. Aoyama, T. Sera T. Mino, T. Mori, Y. Aoyama, T. Sera T. Mino, T. Mori, Y. Aoyama, T. Sera Inhibition of human papillomavirus replication by using artificial zinc-finger nucleases. Inhibition of human papillomavirus replication by using artificial zinc-finger nucleases. Inhibition of human papillomavirus replication by using artificial zinc-finger nucleases. Nucleic acids symposium series, 52, 185-186 Nucleic acids symposium series, 52, 185-186 Nucleic acids symposium series, 52, 185-186 2008 Refereed English Disclose to all
T. Mino, T. Mori, Y. Aoyama, T. Sera T. Mino, T. Mori, Y. Aoyama, T. Sera T. Mino, T. Mori, Y. Aoyama, T. Sera Development of protein-based antiviral drugs for human papillomaviruses. Development of protein-based antiviral drugs for human papillomaviruses. Development of protein-based antiviral drugs for human papillomaviruses. Nucleic acids symposium series, 51, 427-428 Nucleic acids symposium series, 51, 427-428 Nucleic acids symposium series, 51, 427-428 2007 Refereed English Disclose to all
T Mino, T Hatono, N Matsumoto, T Mori, Y Mineta, Y Aoyama, T Sera T Mino, T Hatono, N Matsumoto, T Mori, Y Mineta, Y Aoyama, T Sera T Mino, T Hatono, N Matsumoto, T Mori, Y Mineta, Y Aoyama, T Sera Inhibition of DNA replication of human papillomavirus by artificial zinc finger proteins Inhibition of DNA replication of human papillomavirus by artificial zinc finger proteins Inhibition of DNA replication of human papillomavirus by artificial zinc finger proteins JOURNAL OF VIROLOGY, 80, 11, 5405-5412 JOURNAL OF VIROLOGY, 80, 11, 5405-5412 JOURNAL OF VIROLOGY, 80, 11, 5405-5412 2006/06 Refereed English Research paper(scientific journal) Disclose to all
Mino T, Mori T, Matsumoto N, Mineta Y, Okamoto T, Aoyama Y, Sera T Mino T, Mori T, Matsumoto N, Mineta Y, Okamoto T, Aoyama Y, Sera T Application of artificial zinc-finger proteins to inhibition of DNA replication of human papillomavirus. Application of artificial zinc-finger proteins to inhibition of DNA replication of human papillomavirus. Application of artificial zinc-finger proteins to inhibition of DNA replication of human papillomavirus. Nucleic Acids Symposium Series, 50, 313-314 Nucleic Acids Symposium Series, 50, 313-314 Nucleic Acids Symposium Series, 50, 313-314 2006 Refereed English Disclose to all

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Author Author(Japanese) Author(English) Title Title(Japanese) Title(English) Bibliography Bibliography(Japanese) Bibliography(English) Publication date Refereed paper Language Publishing type Disclose
Yoshinari Nakatsuka, Takashi Mino, Masanori Yoshinaga, Takuya Uehata, Atsuyasu Sato, Tomohiro Handa, Kazuo Chin, Toyohiro Hirai Hirai, Osamu Takeuchi Yoshinari Nakatsuka, Takashi Mino, Masanori Yoshinaga, Takuya Uehata, Atsuyasu Sato, Tomohiro Handa, Kazuo Chin, Toyohiro Hirai Hirai, Osamu Takeuchi Yoshinari Nakatsuka, Takashi Mino, Masanori Yoshinaga, Takuya Uehata, Atsuyasu Sato, Tomohiro Handa, Kazuo Chin, Toyohiro Hirai Hirai, Osamu Takeuchi Pulmonary Regnase-1 functions as a posttranscriptional switch in anti-bacterial immunity Pulmonary Regnase-1 functions as a posttranscriptional switch in anti-bacterial immunity Pulmonary Regnase-1 functions as a posttranscriptional switch in anti-bacterial immunity CYTOKINE, 100, 39-39 CYTOKINE, 100, 39-39 CYTOKINE, 100, 39-39 2017/12 English Summary of the papers read (international conference) Disclose to all
Kazuya Masuda, Barry Ripley, Riko Nishimura, Takashi Mino, Osamu Takeuchi, Go Shioi, Hiroshi Kiyonari, Tadamitsu Kishimoto Kazuya Masuda, Barry Ripley, Riko Nishimura, Takashi Mino, Osamu Takeuchi, Go Shioi, Hiroshi Kiyonari, Tadamitsu Kishimoto Kazuya Masuda, Barry Ripley, Riko Nishimura, Takashi Mino, Osamu Takeuchi, Go Shioi, Hiroshi Kiyonari, Tadamitsu Kishimoto Arid5a contributes to stabilization of IL-6 mRNA, and elevation of IL-6 level in vivo Arid5a contributes to stabilization of IL-6 mRNA, and elevation of IL-6 level in vivo Arid5a contributes to stabilization of IL-6 mRNA, and elevation of IL-6 level in vivo CYTOKINE, 63, 3, 284-284 CYTOKINE, 63, 3, 284-284 CYTOKINE, 63, 3, 284-284 2013/09 English Summary of the papers read (international conference) Disclose to all
Title language:
External funds: competitive funds and Grants-in-Aid for Scientific Research (Kakenhi)
Type Position Title(Japanese) Title(English) Period
若手研究(B) Representative Regnase-1の作用機構から探る自然免疫応答における転写後調節の解明 2013-2014
若手研究(B) Representative Regnase-1の作用機構から探る自然免疫応答における転写後調節の解明 (平成26年度分) 2014/04/01-2015/03/31
基盤研究(C) Representative UPF1の作用機構から探る自然免疫における転写後制御機構の解明 (平成28年度分) 2016/04/01-2017/03/31
基盤研究(C) Representative UPF1の作用機構から探る自然免疫における転写後制御機構の解明 (平成29年度分) 2017/04/01-2018/03/31
基盤研究(C) Representative UPF1の作用機構から探る自然免疫における転写後制御機構の解明 (平成30年度分) 2018/04/01-2019/03/31
基盤研究(B) Representative 免疫システムにおけるmRNAの翻訳制御機構の解明 2019/04/01-2022/03/31
基盤研究(B) Representative 免疫システムにおけるmRNAの翻訳制御機構の解明 (2019年度分) 2019/04/01-2020/03/31
Teaching subject(s)
Name(Japanese) Name(English) Term Department Period
ILASセミナー ILAS Seminar 前期 全学共通科目 2016/04-2017/03
Faculty management (title, position)
Title Period
共同利用機器等委員会 委員 2014/04/01-2017/03/31
化学物質管理委員会 委員 2013/04/01-2017/03/31
(旧ウイルス研)共同利用機器等委員会 委員 2016/10/01-
化学物質管理委員会 委員 2016/10/01-
共同利用機器等委員会 2018/04/01-