宮本 章歳

Last Update: 2020/07/30 08:28:43

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Name(Kanji/Kana/Abecedarium Latinum)
宮本 章歳/ミヤモト アキトシ/Miyamoto, Akitoshi
Primary Affiliation(Org1/Job title)
Graduate Schools Biostudies/Assistant Professor
Academic Degree
Field(Japanese) Field(English) University(Japanese) University(English) Method
修士(生命科学) 東京大学 The University of Tokyo
博士(医学) 東京大学 The University of Tokyo
Personal Profile
(Japanese)
超解像イメージング技術を用いて神経ネットワーク制御機構の解明を行なっている。教育に関しては、大学院の学生に実験ノートの書き方を始め、実験の原理原則をしっかりと教える事で、自ら考え学び行動できる自立した研究者になれるように指導している。
(English)
I am conducting research on neurobiology by using super resolution microscopy in Kyoto university. As for education, I teach graduate students how to write research notebook and fundamental principles of experiments to help them acquire essential skills and knowledge needed to become good researchers.
Language of Instruction
Language(japanese) Language(english) Code
日本語 Japanese jpn
英語 English eng
researchmap URL
https://researchmap.jp/aki-miya
Research Topics
(Japanese)
革新的超解像イメージング法を用いた脳神経ネットワーク機能の解明
(English)
Elucidating the regulatory machinery of neuronal network by using
Overview of the research
(Japanese)
シナプス伝達の強弱を決めるシナプス可塑性は記憶・学習の基盤である。神経細胞には、シナプスで情報を受け取るスパインと呼ばれる構造があり、スパインの形態がシナプス可塑性を制御する。そこで、我々はIRISを用いて、スパインに局在するタンパク質群の局在を詳細に解析する事で、スパイン形態制御を介したシナプス可塑性制御機構の解明を目指す。
(English)
Synaptic plasticity has a fundamental roles on learning and memory formation. Neuron has a lot of small membranous protrusion called spine that receives information from a single axon. The shape and size of spine controls synaptic plasticity. Thus I want to visualize precise distributions and interactions of functional proteins that control the structure of spine by using a novel super resolution microscopy, IRIS, and clarify the regulatory roles of synaptic plasticity.
Published Papers
Author Author(Japanese) Author(English) Title Title(Japanese) Title(English) Bibliography Bibliography(Japanese) Bibliography(English) Publication date Refereed paper Language Publishing type Disclose
Toru Matsu-ura, Hideki Shirakawa, Kenichi G, N. Suzuki, Akitoshi Miyamoto, Kotomi Sugiura, Takayuki Michikawa, Akihiro Kusumi, Katsuhiko Mikoshiba Toru Matsu-ura, Hideki Shirakawa, Kenichi G, N. Suzuki, Akitoshi Miyamoto, Kotomi Sugiura, Takayuki Michikawa, Akihiro Kusumi, Katsuhiko Mikoshiba Dual-FRET imaging of IP3 and Ca2+ revealed Ca2+-induced IP3 production maintains long lasting Ca2+ oscillations in fertilized mouse eggs Dual-FRET imaging of IP3 and Ca2+ revealed Ca2+-induced IP3 production maintains long lasting Ca2+ oscillations in fertilized mouse eggs Dual-FRET imaging of IP3 and Ca2+ revealed Ca2+-induced IP3 production maintains long lasting Ca2+ oscillations in fertilized mouse eggs Scientific Reports, 9, 4829 Scientific Reports, 9, 4829 Scientific Reports, 9, 4829 2019 Refereed English Research paper(scientific journal) Disclose to all
Akitoshi Miyamoto, Katsuhiko Mikoshiba Akitoshi Miyamoto, Katsuhiko Mikoshiba A novel multi lines analysis tool of Ca2+ dynamics reveals the nonuniformity of Ca2+ propagation. A novel multi lines analysis tool of Ca2+ dynamics reveals the nonuniformity of Ca2+ propagation. A novel multi lines analysis tool of Ca2+ dynamics reveals the nonuniformity of Ca2+ propagation. Cell Calcium, 78, 76-80 Cell Calcium, 78, 76-80 Cell Calcium, 78, 76-80 2019 Refereed English Research paper(scientific journal) Disclose to all
Jillian P.Casey, Taisei Hirouchi, Chihiro Hisatsune, Bryan Lynch, Raymond Murphy, Ainee M. Dunne, Akitoshi Miyamoto, Sean Ennis, Nick var der Spek, Bronagh O’Hici, Katsuhiko Mikoshiba, Sally Ann Lynch Jillian P.Casey, Taisei Hirouchi, Chihiro Hisatsune, Bryan Lynch, Raymond Murphy, Ainee M. Dunne, Akitoshi Miyamoto, Sean Ennis, Nick var der Spek, Bronagh O’Hici, Katsuhiko Mikoshiba, Sally Ann Lynch A novel gain-of-function mutation if the ITPR1 suppressor domain causes spinocerebellar ataxia with altered Ca2+ signal patterns. A novel gain-of-function mutation if the ITPR1 suppressor domain causes spinocerebellar ataxia with altered Ca2+ signal patterns. A novel gain-of-function mutation if the ITPR1 suppressor domain causes spinocerebellar ataxia with altered Ca2+ signal patterns. Journal of Neurology, 10.1007/s00415-017-8545-5 Journal of Neurology, 10.1007/s00415-017-8545-5 Journal of Neurology, 10.1007/s00415-017-8545-5 2017 Refereed English Research paper(scientific journal) Disclose to all
Akitoshi Miyamoto, Katsuhiko Mikoshiba Akitoshi Miyamoto, Katsuhiko Mikoshiba Probes for manipulating and monitoring IP3. Probes for manipulating and monitoring IP3. Probes for manipulating and monitoring IP3. Cell Calcium, S0143-4160(16)30188-9 Cell Calcium, S0143-4160(16)30188-9 Cell Calcium, S0143-4160(16)30188-9 2016 Refereed English Research paper(scientific journal) Disclose to all
Akitoshi Miyamoto, Kotomi Sugiura, Katsuhiko Mikoshiba Akitoshi Miyamoto, Kotomi Sugiura, Katsuhiko Mikoshiba Development of a convenient and supersensitive high-throughput screening system for genetically encoded fluorescent probes of small molecules using a confocal microscope. Development of a convenient and supersensitive high-throughput screening system for genetically encoded fluorescent probes of small molecules using a confocal microscope. Development of a convenient and supersensitive high-throughput screening system for genetically encoded fluorescent probes of small molecules using a confocal microscope. Cell Calcium, 61, 1-9 Cell Calcium, 61, 1-9 Cell Calcium, 61, 1-9 2016 Refereed English Research paper(scientific journal) Disclose to all
Ryo Ushioda, Akitoshi Miyamoto, These authors contributed equally to this work, Michio Inoue, Satoshi Watanabe, Masaki Okumura, Ken-ichi Maegawa, Kaiku Uegaki, Shohei Fujii, Yasuko Fukuda, Masataka Umitsu, Jun-ichi Takagi, Kenji Inaba, Katsuhiko Mikoshiba, Kazuhiro Nagata Ryo Ushioda, Akitoshi Miyamoto, These authors contributed equally to this work, Michio Inoue, Satoshi Watanabe, Masaki Okumura, Ken-ichi Maegawa, Kaiku Uegaki, Shohei Fujii, Yasuko Fukuda, Masataka Umitsu, Jun-ichi Takagi, Kenji Inaba, Katsuhiko Mikoshiba, Kazuhiro Nagata Redox-assisted regulation of Ca2+ homeostasis in the endoplasmic reticulum by ERdj5 Redox-assisted regulation of Ca2+ homeostasis in the endoplasmic reticulum by ERdj5 Redox-assisted regulation of Ca2+ homeostasis in the endoplasmic reticulum by ERdj5 Proc Natl Acad Sci U S A., 113, 41, E6055-E6063 Proc Natl Acad Sci U S A., 113, 41, E6055-E6063 Proc Natl Acad Sci U S A., 113, 41, E6055-E6063 2016 Refereed English Research paper(scientific journal) Disclose to all
Hiroko Bannai, Fumihiro Niwa, Mark W Sherwood, Amulya Nidhi Shrivastava, Misa Arizono, Akitoshi Miyamoto, Kotomi Sugiura, Sabine Lévi, Antoine Triller, Katsuhiko Mikoshiba Hiroko Bannai, Fumihiro Niwa, Mark W Sherwood, Amulya Nidhi Shrivastava, Misa Arizono, Akitoshi Miyamoto, Kotomi Sugiura, Sabine Lévi, Antoine Triller, Katsuhiko Mikoshiba Differential calcium-dependent control of synaptic GABAA receptor clustering by ionotropic and metabotropic glutamate receptors Differential calcium-dependent control of synaptic GABAA receptor clustering by ionotropic and metabotropic glutamate receptors Differential calcium-dependent control of synaptic GABAA receptor clustering by ionotropic and metabotropic glutamate receptors Cell Reports, 13, 12, 2768-2780 Cell Reports, 13, 12, 2768-2780 Cell Reports, 13, 12, 2768-2780 2015 Refereed English Research paper(scientific journal) Disclose to all
Akitoshi Miyamoto, Hiroko Bannai, Takayuki Michikawa, Katsuhiko Mikoshiba Akitoshi Miyamoto, Hiroko Bannai, Takayuki Michikawa, Katsuhiko Mikoshiba Optimal microscopic systems for long-term imaging of intracellular calcium using a ratiometric genetically-encoded calcium indicator 遺伝子コード型カルシウムセンサーを用いた長時間細胞内カルシウムイメージングに最適な顕微鏡システムの検証 Optimal microscopic systems for long-term imaging of intracellular calcium using a ratiometric genetically-encoded calcium indicator BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 434, 2, 252-257 , 434, 2, 252-257 BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 434, 2, 252-257 2013/05 Refereed English Research paper(scientific journal) Disclose to all
Misa Arizono, Hiroko Bannai, Kyoko Nakamura, Fumihiro Niwa, Masahiro Enomoto, Toru Matsu-ura, Akitoshi Miyamoto, Mark W. Sherwood, Takeshi Nakamura, Katsuhiko Mikoshiba Misa Arizono, Hiroko Bannai, Kyoko Nakamura, Fumihiro Niwa, Masahiro Enomoto, Toru Matsu-ura, Akitoshi Miyamoto, Mark W. Sherwood, Takeshi Nakamura, Katsuhiko Mikoshiba Misa Arizono, Hiroko Bannai, Kyoko Nakamura, Fumihiro Niwa, Masahiro Enomoto, Toru Matsu-ura, Akitoshi Miyamoto, Mark W. Sherwood, Takeshi Nakamura, Katsuhiko Mikoshiba Receptor-Selective Diffusion Barrier Enhances Sensitivity of Astrocytic Processes to Metabotropic Glutamate Receptor Stimulation Receptor-Selective Diffusion Barrier Enhances Sensitivity of Astrocytic Processes to Metabotropic Glutamate Receptor Stimulation Receptor-Selective Diffusion Barrier Enhances Sensitivity of Astrocytic Processes to Metabotropic Glutamate Receptor Stimulation SCIENCE SIGNALING, 5, 218 SCIENCE SIGNALING, 5, 218 SCIENCE SIGNALING, 5, 218 2012/04 Refereed English Research paper(scientific journal) Disclose to all
Tadashi Shinohara, Takayuki Michikawa, Masahiro Enomoto, Jun-Ichi Goto, Miwako Iwai, Toru Matsu-ura, Haruka Yamazaki, Akitoshi Miyamoto, Akio Suzuki, Katsuhiko Mikoshiba Tadashi Shinohara, Takayuki Michikawa, Masahiro Enomoto, Jun-Ichi Goto, Miwako Iwai, Toru Matsu-ura, Haruka Yamazaki, Akitoshi Miyamoto, Akio Suzuki, Katsuhiko Mikoshiba Tadashi Shinohara, Takayuki Michikawa, Masahiro Enomoto, Jun-Ichi Goto, Miwako Iwai, Toru Matsu-ura, Haruka Yamazaki, Akitoshi Miyamoto, Akio Suzuki, Katsuhiko Mikoshiba Mechanistic basis of bell-shaped dependence of inositol 1,4,5-trisphosphate receptor gating on cytosolic calcium Mechanistic basis of bell-shaped dependence of inositol 1,4,5-trisphosphate receptor gating on cytosolic calcium Mechanistic basis of bell-shaped dependence of inositol 1,4,5-trisphosphate receptor gating on cytosolic calcium PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 108, 37, 15486-15491 PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 108, 37, 15486-15491 PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 108, 37, 15486-15491 2011/09 Refereed English Research paper(scientific journal) Disclose to all
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Awards
Title(Japanese) Title(English) Organization name(Japanese) Organization name(English) Date
YoungGlia Platinum Award 新学術領域「グリアアセンブリによる脳機能発現の制御と病態」 Glial Assembly: a New Regulatory Machinery of Brain Function and Disorders 2016/01/11
Other activities (public organizations)
Committee(Japanese) Committee(English) Title Organization name Period
和光市体育協会役員会 幹事 和光市体育協会 2016/04/01-2018/03/31