山下 晃弘

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Name(Kanji/Kana/Abecedarium Latinum)
山下 晃弘/ヤマシタ アキヒロ/Yamashita, Akihiro
Primary Affiliation(Org1/Job title)
Center for iPS Cell Research and Application (CiRA)/Program-Specific Research Center Assistant Professor
Academic Degree
Field(Japanese) Field(English) University(Japanese) University(English) Method
博士(医学) 滋賀医科大学
researchmap URL
https://researchmap.jp/Aki_yama26
Research Topics
(Japanese)
iPS細胞技術を用いた軟骨疾患の再生治療と創薬
(English)
Regenerative medicine and drug discovery for cartilage diseases trough iPS cells technologies.
Overview of the research
(Japanese)
高齢化社会の到来に伴い運動器の機能維持は重要な課題である。特に軟骨は重要な器官である。軟骨は運動器・骨格の原基であり、自己修復能に乏しい組織であるからである。そのため、軟骨の障害は骨格の変形や運動障害を引き起こす。本研究において、iPS細胞技術を用い軟骨の発生と恒常性の維持を理解するとともに、軟骨疾患の再生治療と創薬への応用を目指した研究を行っている。
(English)
A common problem with age is disease and degeneration of the musculoskeletal tissues. This concern is growing in aging societies like Japan. Cartilage is especially susceptible because it is primordial tissue and has poor regenerative properties. Its damage is associated with skeletal dysplasia and disorders. Through this research program, we are analyzing the development and homeostasis of cartilage and using this information to conduct regenerative medicine and drug discovery using iPS cells technologies.
Fields of research (key words)
Key words(Japanese) Key words(English)
iPS細胞 iPS cells
軟骨 cartilage
bone
骨系統疾患 skeletal dysplasia
再生医療 Regenerative medicine
Published Papers
Author Author(Japanese) Author(English) Title Title(Japanese) Title(English) Bibliography Bibliography(Japanese) Bibliography(English) Publication date Refereed paper Language Publishing type Disclose
Chen X, Yamashita A, Morioka M, Senba T, Kamatani T, Watanabe A, Kosai A, Tsumaki N Chen X, Yamashita A, Morioka M, Senba T, Kamatani T, Watanabe A, Kosai A, Tsumaki N Chen X, Yamashita A, Morioka M, Senba T, Kamatani T, Watanabe A, Kosai A, Tsumaki N Integration Capacity of Human Induced Pluripotent Stem Cell-Derived Cartilage Integration Capacity of Human Induced Pluripotent Stem Cell-Derived Cartilage Integration Capacity of Human Induced Pluripotent Stem Cell-Derived Cartilage Tissue Eng Part A, 25, 5-6, 437-445 Tissue Eng Part A, 25, 5-6, 437-445 Tissue Eng Part A, 25, 5-6, 437-445 2019/04 Refereed English Research paper(scientific journal) Disclose to all
Kimura T, Ozaki T, Fujita K, Yamashita A, Morioka M, Ozono K, Tsumaki N Kimura T, Ozaki T, Fujita K, Yamashita A, Morioka M, Ozono K, Tsumaki N Kimura T, Ozaki T, Fujita K, Yamashita A, Morioka M, Ozono K, Tsumaki N Proposal of patient-specific growth plate cartilage xenograft model for FGFR3 chondrodysplasia. Proposal of patient-specific growth plate cartilage xenograft model for FGFR3 chondrodysplasia. Proposal of patient-specific growth plate cartilage xenograft model for FGFR3 chondrodysplasia. Osteoarthritis and Cartilage, 26, 11, 1551-1561 Osteoarthritis and Cartilage, 26, 11, 1551-1561 Osteoarthritis and Cartilage, 26, 11, 1551-1561 2018 Refereed English Disclose to all
Yamashita A, Tamamura Y, Morioka M, Karagiannis P, Shima N, Tsumaki N Yamashita A, Tamamura Y, Morioka M, Karagiannis P, Shima N, Tsumaki N Yamashita A, Tamamura Y, Morioka M, Karagiannis P, Shima N, Tsumaki N Considerations in hiPSC-derived cartilage for articular cartilage repair Considerations in hiPSC-derived cartilage for articular cartilage repair Considerations in hiPSC-derived cartilage for articular cartilage repair Inflamm Regen, 38, 17 Inflamm Regen, 38, 17 Inflamm Regen, 38, 17 2018 Refereed English Disclose to all
Takeshi Kimura, Akihiro Yamashita, Keiichi Ozono, Noriyuki Tsumaki Takeshi Kimura, Akihiro Yamashita, Keiichi Ozono, Noriyuki Tsumaki Takeshi Kimura, Akihiro Yamashita, Keiichi Ozono, Noriyuki Tsumaki Limited Immunogenicity of Human Induced Pluripotent Stem Cell-Derived Cartilages Limited Immunogenicity of Human Induced Pluripotent Stem Cell-Derived Cartilages Limited Immunogenicity of Human Induced Pluripotent Stem Cell-Derived Cartilages TISSUE ENGINEERING PART A, 22, 23-24, 1367-1375 TISSUE ENGINEERING PART A, 22, 23-24, 1367-1375 TISSUE ENGINEERING PART A, 22, 23-24, 1367-1375 2016/12 Refereed English Research paper(scientific journal) Disclose to all
山下晃弘, 妻木範行 山下晃弘, 妻木範行 iPS細胞を用いた軟骨疾患に対する再生医療開発 iPS細胞を用いた軟骨疾患に対する再生医療開発 月刊糖尿病, 8, 6, 91-97 月刊糖尿病, 8, 6, 91-97 , 8, 6, 91-97 2016 Disclose to all
Yahara Y, Takemori H, Okada M, Kosai A, Yamashita A, Kobayashi T, Fujita K, Itoh Y, Nakamura M, Fuchino H, Kawahara N, Fukui N, Watanabe A, Kimura T, Tsumaki N Yahara Y, Takemori H, Okada M, Kosai A, Yamashita A, Kobayashi T, Fujita K, Itoh Y, Nakamura M, Fuchino H, Kawahara N, Fukui N, Watanabe A, Kimura T, Tsumaki N Yahara Y, Takemori H, Okada M, Kosai A, Yamashita A, Kobayashi T, Fujita K, Itoh Y, Nakamura M, Fuchino H, Kawahara N, Fukui N, Watanabe A, Kimura T, Tsumaki N Pterosin B prevents chondrocyte hypertrophy and osteoarthritis in mice by inhibiting Sik3 Pterosin B prevents chondrocyte hypertrophy and osteoarthritis in mice by inhibiting Sik3 Pterosin B prevents chondrocyte hypertrophy and osteoarthritis in mice by inhibiting Sik3 Nat Commun, 7, 10959 Nat Commun, 7, 10959 Nat Commun, 7, 10959 2016 Refereed English Research paper(scientific journal) Disclose to all
Akihiro Yamashita, Miho Morioka, Yasuhito Yahara, Minoru Okada, Tomohito Kobayashi, Shinichi Kuriyama, Shuichi Matsuda, Noriyuki Tsumaki Akihiro Yamashita, Miho Morioka, Yasuhito Yahara, Minoru Okada, Tomohito Kobayashi, Shinichi Kuriyama, Shuichi Matsuda, Noriyuki Tsumaki Akihiro Yamashita, Miho Morioka, Yasuhito Yahara, Minoru Okada, Tomohito Kobayashi, Shinichi Kuriyama, Shuichi Matsuda, Noriyuki Tsumaki Generation of Scaffoldless Hyaline Cartilaginous Tissue from Human iPSCs Generation of Scaffoldless Hyaline Cartilaginous Tissue from Human iPSCs Generation of Scaffoldless Hyaline Cartilaginous Tissue from Human iPSCs STEM CELL REPORTS, 4, 3, 404-418 STEM CELL REPORTS, 4, 3, 404-418 STEM CELL REPORTS, 4, 3, 404-418 2015/03 Refereed English Research paper(scientific journal) Disclose to all
妻木範行, 山下晃弘, 岡田稔 妻木範行, 山下晃弘, 岡田稔 小児疾患の新規治療開発ーiPS細胞の有用性 小児疾患の新規治療開発ーiPS細胞の有用性 骨と腎代謝, 28, 3, 241-247 骨と腎代謝, 28, 3, 241-247 , 28, 3, 241-247 2015 Disclose to all
山下晃弘, 妻木範行 山下晃弘, 妻木範行 ヒトiPS細胞からの軟骨細胞分化と硝子軟骨組織の作成 ヒトiPS細胞からの軟骨細胞分化と硝子軟骨組織の作成 日本再生医療学会, 14, 4, 70-74 日本再生医療学会, 14, 4, 70-74 , 14, 4, 70-74 2015 Disclose to all
Noriyuki Tsumaki, Minoru Okada, Akihiro Yamashita Noriyuki Tsumaki, Minoru Okada, Akihiro Yamashita Noriyuki Tsumaki, Minoru Okada, Akihiro Yamashita iPS cell technologies and cartilage regeneration iPS cell technologies and cartilage regeneration iPS cell technologies and cartilage regeneration BONE, 70, 48-54 BONE, 70, 48-54 BONE, 70, 48-54 2015/01 Refereed English Research paper(scientific journal) Disclose to all
Minoru Okada, Shiro Ikegawa, Miho Morioka, Akihiro Yamashita, Atsushi Saito, Hideaki Sawai, Jun Murotsuki, Hirofumi Ohashi, Toshio Okamoto, Gen Nishimura, Kazunori Imaizumi, Noriyuki Tsumaki Minoru Okada, Shiro Ikegawa, Miho Morioka, Akihiro Yamashita, Atsushi Saito, Hideaki Sawai, Jun Murotsuki, Hirofumi Ohashi, Toshio Okamoto, Gen Nishimura, Kazunori Imaizumi, Noriyuki Tsumaki Minoru Okada, Shiro Ikegawa, Miho Morioka, Akihiro Yamashita, Atsushi Saito, Hideaki Sawai, Jun Murotsuki, Hirofumi Ohashi, Toshio Okamoto, Gen Nishimura, Kazunori Imaizumi, Noriyuki Tsumaki Modeling type II collagenopathy skeletal dysplasia by directed conversion and induced pluripotent stem cells Modeling type II collagenopathy skeletal dysplasia by directed conversion and induced pluripotent stem cells Modeling type II collagenopathy skeletal dysplasia by directed conversion and induced pluripotent stem cells HUMAN MOLECULAR GENETICS, 24, 2, 299-313 HUMAN MOLECULAR GENETICS, 24, 2, 299-313 HUMAN MOLECULAR GENETICS, 24, 2, 299-313 2015/01 Refereed English Research paper(scientific journal) Disclose to all
Akihiro Yamashita, Miho Morioka, Hiromi Kishi, Takeshi Kimura, Yasuhito Yahara, Minoru Okada, Kaori Fujita, Hideaki Sawai, Shiro Ikegawa, Noriyuki Tsumaki Akihiro Yamashita, Miho Morioka, Hiromi Kishi, Takeshi Kimura, Yasuhito Yahara, Minoru Okada, Kaori Fujita, Hideaki Sawai, Shiro Ikegawa, Noriyuki Tsumaki Akihiro Yamashita, Miho Morioka, Hiromi Kishi, Takeshi Kimura, Yasuhito Yahara, Minoru Okada, Kaori Fujita, Hideaki Sawai, Shiro Ikegawa, Noriyuki Tsumaki Statin treatment rescues FGFR3 skeletal dysplasia phenotypes Statin treatment rescues FGFR3 skeletal dysplasia phenotypes Statin treatment rescues FGFR3 skeletal dysplasia phenotypes NATURE, 513, 7519, 507-+ NATURE, 513, 7519, 507-+ NATURE, 513, 7519, 507-+ 2014/09 Refereed English Research paper(scientific journal) Disclose to all
Akihiro Yamashita, Shiying Liu, Knut Woltjen, Bradley Thomas, Guoliang Meng, Akitsu Hotta, Kazutoshi Takahashi, James Ellis, Shinya Yamanaka, Derrick E. Rancourt Akihiro Yamashita, Shiying Liu, Knut Woltjen, Bradley Thomas, Guoliang Meng, Akitsu Hotta, Kazutoshi Takahashi, James Ellis, Shinya Yamanaka, Derrick E. Rancourt Akihiro Yamashita, Shiying Liu, Knut Woltjen, Bradley Thomas, Guoliang Meng, Akitsu Hotta, Kazutoshi Takahashi, James Ellis, Shinya Yamanaka, Derrick E. Rancourt Cartilage tissue engineering identifies abnormal human induced pluripotent stem cells Cartilage tissue engineering identifies abnormal human induced pluripotent stem cells Cartilage tissue engineering identifies abnormal human induced pluripotent stem cells SCIENTIFIC REPORTS, 3, 1978 SCIENTIFIC REPORTS, 3, 1978 SCIENTIFIC REPORTS, 3, 1978 2013/06 Refereed English Research paper(scientific journal) Disclose to all
妻木範行, 岡田稔, 山下晃弘 妻木範行, 岡田稔, 山下晃弘 iPS細胞を使うー軟骨の研究へ iPS細胞を使うー軟骨の研究へ 整形外科, 64, 10, 1106-1109 整形外科, 64, 10, 1106-1109 , 64, 10, 1106-1109 2013 Disclose to all
山下晃弘, 妻木範行 山下晃弘, 妻木範行 iPS細胞由来軟骨細胞を用いた再生治療開発 iPS細胞由来軟骨細胞を用いた再生治療開発 Phama Medica, 31, 4, 29-32 Phama Medica, 31, 4, 29-32 , 31, 4, 29-32 2013 Disclose to all
Outani H, Okada M, Yamashita A, Nakagawa K, Yoshikawa H, Tsumaki N Outani H, Okada M, Yamashita A, Nakagawa K, Yoshikawa H, Tsumaki N Outani H, Okada M, Yamashita A, Nakagawa K, Yoshikawa H, Tsumaki N Direct induction of chondrogenic cells from human dermal fibroblast culture by defined factors Direct induction of chondrogenic cells from human dermal fibroblast culture by defined factors. Direct induction of chondrogenic cells from human dermal fibroblast culture by defined factors PLoS One, 8, e77365 PLoS One, 8, e77365 PLoS One, 8, e77365 2013 Refereed Disclose to all
Taiani JT, Krawetz RJ, Yamashita A, Pauchard Y, Buie HR, Ponjevic D, Boyd SK, Rancourt DE, Matyas JR Taiani JT, Krawetz RJ, Yamashita A, Pauchard Y, Buie HR, Ponjevic D, Boyd SK, Rancourt DE, Matyas JR Taiani JT, Krawetz RJ, Yamashita A, Pauchard Y, Buie HR, Ponjevic D, Boyd SK, Rancourt DE, Matyas JR Embryonic stem cells incorporate into newly formed bone and do not form tumors in an immunocompetent mouse fracture model. Embryonic stem cells incorporate into newly formed bone and do not form tumors in an immunocompetent mouse fracture model. Embryonic stem cells incorporate into newly formed bone and do not form tumors in an immunocompetent mouse fracture model. Cell Transplant, 22, 1453-1462 Cell Transplant, 22, 1453-1462 Cell Transplant, 22, 1453-1462 2013 Refereed Disclose to all
Mehdi Shafa, Kirsten Sjonnesen, Akihiro Yamashita, Shiying Liu, Marek Michalak, Michael S. Kallos, Derrick E. Rancourt Mehdi Shafa, Kirsten Sjonnesen, Akihiro Yamashita, Shiying Liu, Marek Michalak, Michael S. Kallos, Derrick E. Rancourt Mehdi Shafa, Kirsten Sjonnesen, Akihiro Yamashita, Shiying Liu, Marek Michalak, Michael S. Kallos, Derrick E. Rancourt Expansion and long-term maintenance of induced pluripotent stem cells in stirred suspension bioreactors Expansion and long-term maintenance of induced pluripotent stem cells in stirred suspension bioreactors Expansion and long-term maintenance of induced pluripotent stem cells in stirred suspension bioreactors JOURNAL OF TISSUE ENGINEERING AND REGENERATIVE MEDICINE, 6, 6, 462-472 JOURNAL OF TISSUE ENGINEERING AND REGENERATIVE MEDICINE, 6, 6, 462-472 JOURNAL OF TISSUE ENGINEERING AND REGENERATIVE MEDICINE, 6, 6, 462-472 2012/06 Refereed English Research paper(scientific journal) Disclose to all
Mehdi Shafa, Brad Day, Akihiro Yamashita, Guoliang Meng, Shiying Liu, Roman Krawetz, Derrick E. Rancourt Shafa M, Day B, Yamashita A, Meng G, Liu S, Krawetz R, Rancourt DE Mehdi Shafa, Brad Day, Akihiro Yamashita, Guoliang Meng, Shiying Liu, Roman Krawetz, Derrick E. Rancourt Derivation of iPSCs in stirred suspension bioreactors Enhanced derivation of iPS cells in stirred suspension bioreactors」 Derivation of iPSCs in stirred suspension bioreactors NATURE METHODS, 9, 5, 465-U72 Nat Methods, 9, 5, 465-U72 NATURE METHODS, 9, 5, 465-U72 2012/05 Refereed English Research paper(scientific journal) Disclose to all
Roz Alfred, Jaymi T. Taiani, Roman J. Krawetz, Akihiro Yamashita, Derrick E. Rancourt, Michael S. Kallos Roz Alfred, Jaymi T. Taiani, Roman J. Krawetz, Akihiro Yamashita, Derrick E. Rancourt, Michael S. Kallos Roz Alfred, Jaymi T. Taiani, Roman J. Krawetz, Akihiro Yamashita, Derrick E. Rancourt, Michael S. Kallos Large-scale production of murine embryonic stem cell-derived osteoblasts and chondrocytes on microcarriers in serum-free media Large-scale production of murine embryonic stem cell-derived osteoblasts and chondrocytes on microcarriers in serum-free media Large-scale production of murine embryonic stem cell-derived osteoblasts and chondrocytes on microcarriers in serum-free media BIOMATERIALS, 32, 26, 6006-6016 BIOMATERIALS, 32, 26, 6006-6016 BIOMATERIALS, 32, 26, 6006-6016 2011/09 Refereed English Research paper(scientific journal) Disclose to all
Akihiro Yamashita, Sandi Nishikawa, Derrick E. Rancourt Akihiro Yamashita, Sandi Nishikawa, Derrick E. Rancourt Akihiro Yamashita, Sandi Nishikawa, Derrick E. Rancourt Identification of Five Developmental Processes during Chondrogenic Differentiation of Embryonic Stem Cells Identification of Five Developmental Processes during Chondrogenic Differentiation of Embryonic Stem Cells Identification of Five Developmental Processes during Chondrogenic Differentiation of Embryonic Stem Cells PLOS ONE, 5, 6, e10998 PLOS ONE, 5, 6, e10998 PLOS ONE, 5, 6, e10998 2010/06 Refereed English Research paper(scientific journal) Disclose to all
Akihiro Yamashita, Sandi Nishikawa, Derrick E. Rancourt Akihiro Yamashita, Sandi Nishikawa, Derrick E. Rancourt Akihiro Yamashita, Sandi Nishikawa, Derrick E. Rancourt Microenvironment Modulates Osteogenic Cell Lineage Commitment in Differentiated Embryonic Stem Cells Microenvironment Modulates Osteogenic Cell Lineage Commitment in Differentiated Embryonic Stem Cells Microenvironment Modulates Osteogenic Cell Lineage Commitment in Differentiated Embryonic Stem Cells PLOS ONE, 5, 3, e9663 PLOS ONE, 5, 3, e9663 PLOS ONE, 5, 3, e9663 2010/03 Refereed English Research paper(scientific journal) Disclose to all
A. Yamashita, R. Krawetz, D. E. Rancourt Yamashita A, Krawetz R, Rancourt DE A. Yamashita, R. Krawetz, D. E. Rancourt Loss of discordant cells during micro-mass differentiation of embryonic stem cells into the chondrocyte lineage Loss of discordant cells during micro-mass differentiation of embryonic stem cells into the chondrocyte lineage」『Cell Death and Differentiation Loss of discordant cells during micro-mass differentiation of embryonic stem cells into the chondrocyte lineage CELL DEATH AND DIFFERENTIATION, 16, 2, 278-286 Cell Death and Differentiation, 16, 2, 278-286 CELL DEATH AND DIFFERENTIATION, 16, 2, 278-286 2009/02 Refereed English Research paper(scientific journal) Disclose to all
A Yamashita, T Takada, G Yamamoto, R Torii A Yamashita, T Takada, G Yamamoto, R Torii A Yamashita, T Takada, G Yamamoto, R Torii Stable maintenance of monkey embryonic stem cells in the absence of bFGF Stable maintenance of monkey embryonic stem cells in the absence of bFGF Stable maintenance of monkey embryonic stem cells in the absence of bFGF TRANSPLANTATION PROCEEDINGS, 38, 5, 1614-1615 TRANSPLANTATION PROCEEDINGS, 38, 5, 1614-1615 TRANSPLANTATION PROCEEDINGS, 38, 5, 1614-1615 2006/06 Refereed English Research paper(scientific journal) Disclose to all
Yamashita A, Takada T, Kanbe-Omatsu M, Nemoto K, Matsuura H, Yamamoto G, Torii R Yamashita A, Takada T, Kanbe-Omatsu M, Nemoto K, Matsuura H, Yamamoto G, Torii R Yamashita A, Takada T, Kanbe-Omatsu M, Nemoto K, Matsuura H, Yamamoto G, Torii R Monkey Embryonic Stem Cells differentiate into adipocytes In Vitro Monkey Embryonic Stem Cells differentiate into adipocytes In Vitro Monkey Embryonic Stem Cells differentiate into adipocytes In Vitro Cloning Stem. Cells, 8, 3-9 Cloning Stem. Cells, 8, 3-9 Cloning Stem. Cells, 8, 3-9 2006 Refereed Disclose to all
Yamashita A, Takada T, Nemoto K, Yamamoto G, Torii R Yamashita A, Takada T, Nemoto K, Yamamoto G, Torii R Yamashita A, Takada T, Nemoto K, Yamamoto G, Torii R Transient suppression of PPARγ directed ES cells into an osteoblastic lineage Transient suppression of PPARγ directed ES cells into an osteoblastic lineage Transient suppression of PPARγ directed ES cells into an osteoblastic lineage FEBS Letter, 580, 2121-2125 FEBS Letter, 580, 2121-2125 FEBS Letter, 580, 2121-2125 2006 Refereed Disclose to all
T Takada, K Nemoto, A Yamashita, M Kato, Y Kondo, R Torii T Takada, K Nemoto, A Yamashita, M Kato, Y Kondo, R Torii T Takada, K Nemoto, A Yamashita, M Kato, Y Kondo, R Torii Efficient gene silencing and cell differentiation using siRNA in mouse and monkey ES cells Efficient gene silencing and cell differentiation using siRNA in mouse and monkey ES cells Efficient gene silencing and cell differentiation using siRNA in mouse and monkey ES cells BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 331, 4, 1039-1044 BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 331, 4, 1039-1044 BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 331, 4, 1039-1044 2005/06 Refereed English Research paper(scientific journal) Disclose to all
Yamashita A, Takada T, Narita J, Yamamoto G, Torii R Yamashita A, Takada T, Narita J, Yamamoto G, Torii R Yamashita A, Takada T, Narita J, Yamamoto G, Torii R Osteoblastic Differentiation of Monkey Embryonic Stem Cells In Vitro Osteoblastic Differentiation of Monkey Embryonic Stem Cells In Vitro Osteoblastic Differentiation of Monkey Embryonic Stem Cells In Vitro Cloning Stem. Cells, 7, 232-237 Cloning Stem. Cells, 7, 232-237 Cloning Stem. Cells, 7, 232-237 2005 Refereed Disclose to all

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Conference Activities & Talks
Title Title(Japanese) Title(English) Conference Conference(Japanese) Conference(English) Promotor Promotor(Japanese) Promotor(English) Date Language Assortment Disclose
iPS細胞由来軟骨の移植による限局した関節軟骨損傷の再生治療研究[Invited] iPS細胞由来軟骨の移植による限局した関節軟骨損傷の再生治療研究 [Invited] 関節病学会 関節病学会 2017/11/16 Japanese Oral presentation(invited, special) Disclose to all
Regenerative treatment of focal defects of articular cartilage with iPS cell-derived cartilage[Invited] Regenerative treatment of focal defects of articular cartilage with iPS cell-derived cartilage [Invited] Regenerative treatment of focal defects of articular cartilage with iPS cell-derived cartilage [Invited] APLAR APLAR APLAR 2016/09/27 English Oral presentation(invited, special) Disclose to all
ヒトiPS細胞由来軟骨の開発[Invited] ヒトiPS細胞由来軟骨の開発 [Invited] 2016/07/21 Japanese Oral presentation(invited, special) Disclose to all
ヒトiPS細胞由来軟骨を用いた関節軟骨再生治療の試み[Invited] ヒトiPS細胞由来軟骨を用いた関節軟骨再生治療の試み [Invited] 日本炎症・再生医学会 日本炎症・再生医学会 2016/06/16 Japanese Oral presentation(invited, special) Disclose to all
スタチンによるFGFR3軟骨形成異常症の病態回復[Invited] スタチンによるFGFR3軟骨形成異常症の病態回復 [Invited] 軟骨代謝学会 軟骨代謝学会 2016/02/20 Japanese Oral presentation(invited, special) Disclose to all
スタチンによるFGFR3軟骨形成異常症の病態回復 – iPS細胞疾患モデルを用いて–[Invited] スタチンによるFGFR3軟骨形成異常症の病態回復 – iPS細胞疾患モデルを用いて– [Invited] 第30回日本整形外科学会基礎学術集会 第30回日本整形外科学会基礎学術集会 2015/10/23 Japanese Oral presentation(invited, special) Disclose to all
iPS細胞疾患モデルを用いたFGFR3軟骨形成異常症の研究[Invited] iPS細胞疾患モデルを用いたFGFR3軟骨形成異常症の研究 [Invited] 骨代謝学会 骨代謝学会 2015/07/23 Japanese Oral presentation(invited, special) Disclose to all
iPS細胞を使った軟骨疾患治療法の開発[Invited] iPS細胞を使った軟骨疾患治療法の開発 [Invited] 第3回労災医療研修会 第3回労災医療研修会 2015/02/20 Japanese Public discourse, seminar, tutorial, course, lecture and others Disclose to all
スタチンによるFGFR3病の病態改善 ー疾患特異的iPS細胞を用いてー[Invited] スタチンによるFGFR3病の病態改善 ー疾患特異的iPS細胞を用いてー [Invited] 第17回日本骨代謝研究会 第17回日本骨代謝研究会 2014/11/26 Japanese Oral presentation(invited, special) Disclose to all
ヒトiPS細胞から軟骨細胞への分化誘導[Invited] ヒトiPS細胞から軟骨細胞への分化誘導 [Invited] 日本骨代謝学会 日本骨代謝学会 2014/07/24 Japanese Oral presentation(invited, special) Disclose to all
Revealing the oncogenic risk of human induced pluripotent stem cells using in vitro cartilage tissue engineering[Invited] Revealing the oncogenic risk of human induced pluripotent stem cells using in vitro cartilage tissue engineering [Invited] Revealing the oncogenic risk of human induced pluripotent stem cells using in vitro cartilage tissue engineering [Invited] BMB retreat BMB retreat BMB retreat 2011/04/29 English Symposium workshop panel(nominated) Disclose to all
In vitro cartilage differentiation reveals the risk of oncogenic transformation in human induced pluripotent stem cells[Invited] In vitro cartilage differentiation reveals the risk of oncogenic transformation in human induced pluripotent stem cells [Invited] In vitro cartilage differentiation reveals the risk of oncogenic transformation in human induced pluripotent stem cells [Invited] International Research Center for Molecular Science in Tooth and Bone Disease, 3rd Retreat Camp International Research Center for Molecular Science in Tooth and Bone Disease, 3rd Retreat Camp International Research Center for Molecular Science in Tooth and Bone Disease, 3rd Retreat Camp 2011/02/01 English Symposium workshop panel(nominated) Disclose to all
In vitro cartilage differentiation reveals the risk of oncogenesis in human induced pluripotent stem cells In vitro cartilage differentiation reveals the risk of oncogenesis in human induced pluripotent stem cells In vitro cartilage differentiation reveals the risk of oncogenesis in human induced pluripotent stem cells Stem Cell Network 10th Annual General Meeting Stem Cell Network 10th Annual General Meeting Stem Cell Network 10th Annual General Meeting 2010/11/22 English Oral presentation(general) Disclose to all
Transient suppression of PPARγ directed ES cells into an osteoblastic lineage[Invited] Transient suppression of PPARγ directed ES cells into an osteoblastic lineage [Invited] Transient suppression of PPARγ directed ES cells into an osteoblastic lineage [Invited] Southern Alberta. Cancer Research Institute Southern Alberta. Cancer Research Institute Southern Alberta. Cancer Research Institute 2007/01/15 English Public discourse, seminar, tutorial, course, lecture and others Disclose to all

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Awards
Title(Japanese) Title(English) Organization name(Japanese) Organization name(English) Date
第21回日本軟骨代謝学会賞 日本軟骨代謝学 2016/02/20
日本再生医療学会奨励賞 基礎領域 日本再生医療学会 2015/03/20
BMB Postdoctoral Fellow Award Department of Biochemistry and molecular biology, Uof Calgary 2011
Excellent Postdoctoral Fellow Award SACRI 2010
External funds: competitive funds and Grants-in-Aid for Scientific Research (Kakenhi)
Type Position Title(Japanese) Title(English) Period
研究活動スタート支援 Representative リプログラミング法を用いた致死性骨異形成症の病態解明と治療法の探索 2012-2013
若手研究(B) Representative 患者由来iPS細胞を用いたFGFR3病の病態の解明と治療法の探索 (平成26年度分) 2014/04/01-2015/03/31
若手研究(B) Representative 患者由来iPS細胞を用いたFGFR3病の病態の解明と治療法の探索 (平成28年度分) 2016/04/01-2017/03/31
基盤(B) Representative 軟骨膜の機能解明 ーiPS細胞由来軟骨を用いてー 2018/04/01-2021/03/31
基盤研究(B) Representative 軟骨膜の機能解明 ーiPS細胞由来軟骨を用いてー (平成30年度分) 2018/04/01-2019/03/31
基盤研究(B) Representative 軟骨膜の機能解明 ーiPS細胞由来軟骨を用いてー (2019年度分) 2019/04/01-2020/03/31
Faculty management (title, position)
Title Period
化学物質管理委員会1号委員 2016/07/26-2022/03/31