竹本 靖

Last Update: 2019/06/28 14:16:20

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Name(Kanji/Kana/Abecedarium Latinum)
竹本 靖/タケモト ヤスシ/Takemoto, Yasushi
Primary Affiliation(Org1/Job title)
Institute for Chemical Research (ICR)/Assistant Professor
Affiliated programs (koza)
Org1 Job title
Graduate Schools Medicine Assistant Professor
Contact Address
Type Address(Japanese) Address(English)
Office 〒661-0011 京都府宇治市五ヶ庄 京都大学 化学研究所 生体機能化学研究系 ケミカルバイオロジー研究領域 Chemical Biology, Division of Biochemistry, Institute for Chemical Research, Kyoto University, Gokasho, Uji, Kyoto 611-0011, JAPAN
Academic Degree
Field(Japanese) Field(English) University(Japanese) University(English) Method
修士(工学) 慶應義塾大学
博士(工学) 慶應義塾大学
researchmap URL
https://researchmap.jp/read0164640
Fields of research (key words)
Key words(Japanese) Key words(English)
ケミカルバイオロジー chemical biology
Published Papers
Author Author(Japanese) Author(English) Title Title(Japanese) Title(English) Bibliography Bibliography(Japanese) Bibliography(English) Publication date Refereed paper Language Publishing type Disclose
Di Mao, Watson Chung Xie Khim, Tomoko Andoh-Noda, Ying Qin, Shin-ichi Sato, Yasushi Takemoto, Wado Akamatsu, Hideyuki Okano, Motonari Uesugi Di Mao, Watson Chung Xie Khim, Tomoko Andoh-Noda, Ying Qin, Shin-ichi Sato, Yasushi Takemoto, Wado Akamatsu, Hideyuki Okano, Motonari Uesugi Di Mao, Watson Chung Xie Khim, Tomoko Andoh-Noda, Ying Qin, Shin-ichi Sato, Yasushi Takemoto, Wado Akamatsu, Hideyuki Okano, Motonari Uesugi Chemical Decontamination of iPS Cell-Derived Neural Cell Mixtures Chemical Decontamination of iPS Cell-Derived Neural Cell Mixtures Chemical Decontamination of iPS Cell-Derived Neural Cell Mixtures Chemical Communications, 54, 1355-1358 Chemical Communications, 54, 1355-1358 Chemical Communications, 54, 1355-1358 2018 Refereed English Research paper(scientific journal) Disclose to all
Andrei Ursu, Damir J. Illich, Yasushi Takemoto, Arthur T. Porfetye, Miao Zhang, Andreas Brockmeyer, Petra Janning, Nobumoto Watanabe, Hiroyuki Osada, Ingrid R. Vetter, Slava Ziegler, Hans R. Schöler, Herbert Waldmann Andrei Ursu, Damir J. Illich, Yasushi Takemoto, Arthur T. Porfetye, Miao Zhang, Andreas Brockmeyer, Petra Janning, Nobumoto Watanabe, Hiroyuki Osada, Ingrid R. Vetter, Slava Ziegler, Hans R. Schöler, Herbert Waldmann Andrei Ursu, Damir J. Illich, Yasushi Takemoto, Arthur T. Porfetye, Miao Zhang, Andreas Brockmeyer, Petra Janning, Nobumoto Watanabe, Hiroyuki Osada, Ingrid R. Vetter, Slava Ziegler, Hans R. Schöler, Herbert Waldmann Epiblastin A induces reprogramming of epiblast stem cells into embryonic stem cells by inhibition of casein kinase 1 Epiblastin A induces reprogramming of epiblast stem cells into embryonic stem cells by inhibition of casein kinase 1 Epiblastin A induces reprogramming of epiblast stem cells into embryonic stem cells by inhibition of casein kinase 1 Cell Chemical Biology, 23, 494-507 Cell Chemical Biology, 23, 494-507 Cell Chemical Biology, 23, 494-507 2016 Refereed English Research paper(scientific journal) Disclose to all
Yasushi Takemoto, Akihiro Ito, Hideaki Niwa, Mutsumi Okamura, Takashi Fujiwara, Tomoya Hirano, Noriko Handa, Takashi Umehara, Takeshi Sonoda, Kenji Ogawa, Mohammad Tariq, Norikazu Nishino, Shingo Dan, Hiroyuki Kagechika, Takao Yamori, Shigeyuki Yokoyama, Minoru Yoshida Yasushi Takemoto, Akihiro Ito, Hideaki Niwa, Mutsumi Okamura, Takashi Fujiwara, Tomoya Hirano, Noriko Handa, Takashi Umehara, Takeshi Sonoda, Kenji Ogawa, Mohammad Tariq, Norikazu Nishino, Shingo Dan, Hiroyuki Kagechika, Takao Yamori, Shigeyuki Yokoyama, Minoru Yoshida Yasushi Takemoto, Akihiro Ito, Hideaki Niwa, Mutsumi Okamura, Takashi Fujiwara, Tomoya Hirano, Noriko Handa, Takashi Umehara, Takeshi Sonoda, Kenji Ogawa, Mohammad Tariq, Norikazu Nishino, Shingo Dan, Hiroyuki Kagechika, Takao Yamori, Shigeyuki Yokoyama, Minoru Yoshida Identification of cyproheptadine as an inhibitor of SET domain containing lysine methyltransferase 7/9 (Set7/9) that regulates estrogen-dependent transcription Identification of cyproheptadine as an inhibitor of SET domain containing lysine methyltransferase 7/9 (Set7/9) that regulates estrogen-dependent transcription Identification of cyproheptadine as an inhibitor of SET domain containing lysine methyltransferase 7/9 (Set7/9) that regulates estrogen-dependent transcription Journal of Medicinal Chemistry, 59, 3650-3660 Journal of Medicinal Chemistry, 59, 3650-3660 Journal of Medicinal Chemistry, 59, 3650-3660 2016 Refereed English Research paper(scientific journal) Disclose to all
Shigeyuki Magi, Yasushi Takemoto, Hiroki Kobayashi, Masato Kasamatsu, Takahiro Akita, Ayako Tanaka, Kei Takano, Etus Tashiro, Yasuhiro Igarashi, Masaya Imoto Shigeyuki Magi, Yasushi Takemoto, Hiroki Kobayashi, Masato Kasamatsu, Takahiro Akita, Ayako Tanaka, Kei Takano, Etus Tashiro, Yasuhiro Igarashi, Masaya Imoto Shigeyuki Magi, Yasushi Takemoto, Hiroki Kobayashi, Masato Kasamatsu, Takahiro Akita, Ayako Tanaka, Kei Takano, Etus Tashiro, Yasuhiro Igarashi, Masaya Imoto 5-Lipoxygenase and CysLT1 regulate EGF-induced cell migration through Tiam1 upregulation and Rac1 activation 5-Lipoxygenase and CysLT1 regulate EGF-induced cell migration through Tiam1 upregulation and Rac1 activation 5-Lipoxygenase and CysLT1 regulate EGF-induced cell migration through Tiam1 upregulation and Rac1 activation Cancer Science, 105, 290-296 Cancer Science, 105, 290-296 Cancer Science, 105, 290-296 2014 Refereed English Research paper(scientific journal) Disclose to all
Hongfang Chi, Yasushi Takemoto, Tienabe K. Nsiama, Tamaki Kato, Norikazu Nishino, Akihiro Ito, Minoru Yoshida Hongfang Chi, Yasushi Takemoto, Tienabe K. Nsiama, Tamaki Kato, Norikazu Nishino, Akihiro Ito, Minoru Yoshida Hongfang Chi, Yasushi Takemoto, Tienabe K. Nsiama, Tamaki Kato, Norikazu Nishino, Akihiro Ito, Minoru Yoshida Design and synthesis of peptide-MCA substrates for a novel assay of histone methyltransferases and their inhibitors Design and synthesis of peptide-MCA substrates for a novel assay of histone methyltransferases and their inhibitors Design and synthesis of peptide-MCA substrates for a novel assay of histone methyltransferases and their inhibitors Bioorganic & Medicinal Chemistry, 22, 1268-1275 Bioorganic & Medicinal Chemistry, 22, 1268-1275 Bioorganic & Medicinal Chemistry, 22, 1268-1275 2014 Refereed English Research paper(scientific journal) Disclose to all
Shigeyuki Magi, Tetsuo Shitara, Yasushi Takemoto, Masato Sawada, Mitsuhiro Kitagawa, Etsu Tashiro, Yoshikazu Takahashi, Masaya Imoto Shigeyuki Magi, Tetsuo Shitara, Yasushi Takemoto, Masato Sawada, Mitsuhiro Kitagawa, Etsu Tashiro, Yoshikazu Takahashi, Masaya Imoto Shigeyuki Magi, Tetsuo Shitara, Yasushi Takemoto, Masato Sawada, Mitsuhiro Kitagawa, Etsu Tashiro, Yoshikazu Takahashi, Masaya Imoto Novel derivatives of aclacinomycin A block cancer cell migration through inhibition of farnesyl transferase Novel derivatives of aclacinomycin A block cancer cell migration through inhibition of farnesyl transferase Novel derivatives of aclacinomycin A block cancer cell migration through inhibition of farnesyl transferase The Journal of Antibiotics, 66, 3, 165-170 The Journal of Antibiotics, 66, 3, 165-170 The Journal of Antibiotics, 66, 3, 165-170 2013 Refereed English Research paper(scientific journal) Disclose to all
Yi Sun, Kentaro Takada, Yasushi Takemoto, Minoru Yoshida, Yuichi Nogi, Shigeru Okada, Shigeki Matsunaga Yi Sun, Kentaro Takada, Yasushi Takemoto, Minoru Yoshida, Yuichi Nogi, Shigeru Okada, Shigeki Matsunaga Yi Sun, Kentaro Takada, Yasushi Takemoto, Minoru Yoshida, Yuichi Nogi, Shigeru Okada, Shigeki Matsunaga Gliotoxin Analogues from a Marine-Derived Fungus, Penicillium sp., and Their Cytotoxic and Histone Methyltransferase Inhibitory Activities Gliotoxin Analogues from a Marine-Derived Fungus, Penicillium sp., and Their Cytotoxic and Histone Methyltransferase Inhibitory Activities Gliotoxin Analogues from a Marine-Derived Fungus, Penicillium sp., and Their Cytotoxic and Histone Methyltransferase Inhibitory Activities Journal of Natural Products, 75, 111-114 Journal of Natural Products, 75, 111-114 Journal of Natural Products, 75, 111-114 2012 Refereed English Research paper(scientific journal) Disclose to all
Masanari Takahashi, Yasushi Takemoto, Tadahiro Shimazu, Hisashi Kawasaki, Makoto Tachibana, Yoichi Shinkai, Motoki Takagi, Kazuo Shin-ya, Yasuhiro Igarashi, Akihiro Ito, Minoru Yoshida Masanari Takahashi, Yasushi Takemoto, Tadahiro Shimazu, Hisashi Kawasaki, Makoto Tachibana, Yoichi Shinkai, Motoki Takagi, Kazuo Shin-ya, Yasuhiro Igarashi, Akihiro Ito, Minoru Yoshida Masanari Takahashi, Yasushi Takemoto, Tadahiro Shimazu, Hisashi Kawasaki, Makoto Tachibana, Yoichi Shinkai, Motoki Takagi, Kazuo Shin-ya, Yasuhiro Igarashi, Akihiro Ito, Minoru Yoshida Inhibition of histone H3K9 methyltransferases by gliotoxin and related epipolythiodioxopiperazines Inhibition of histone H3K9 methyltransferases by gliotoxin and related epipolythiodioxopiperazines Inhibition of histone H3K9 methyltransferases by gliotoxin and related epipolythiodioxopiperazines The Journal of Antibiotics, 65, 5, 263-265 The Journal of Antibiotics, 65, 5, 263-265 The Journal of Antibiotics, 65, 5, 263-265 2012 Refereed English Research paper(scientific journal) Disclose to all
Hiroki Kobayashi, Yusuke Ogura, Masato Sawada, Ryoji Nakayama, Kei Takano, Yusuke Minato, Yasushi Takemoto, Etsu Tashiro, Hidenori Watanabe, Masaya Imoto Hiroki Kobayashi, Yusuke Ogura, Masato Sawada, Ryoji Nakayama, Kei Takano, Yusuke Minato, Yasushi Takemoto, Etsu Tashiro, Hidenori Watanabe, Masaya Imoto Hiroki Kobayashi, Yusuke Ogura, Masato Sawada, Ryoji Nakayama, Kei Takano, Yusuke Minato, Yasushi Takemoto, Etsu Tashiro, Hidenori Watanabe, Masaya Imoto Involvement of 14-3-3 proteins in the second EGF-induced wave of Rac1 activation in the process of cell migration Involvement of 14-3-3 proteins in the second EGF-induced wave of Rac1 activation in the process of cell migration Involvement of 14-3-3 proteins in the second EGF-induced wave of Rac1 activation in the process of cell migration Journal of Biological Chemistry, 286, 45, 39259-39268 Journal of Biological Chemistry, 286, 45, 39259-39268 Journal of Biological Chemistry, 286, 45, 39259-39268 2011/08 Refereed English Research paper(scientific journal) Disclose to all
Masato Sawada, Shin-ichiro Kubo, Koji Matsumura, Yasushi Takemoto, Hiroki Kobayashi, Etsu Tashiro, Takeshi Kitahara, Hidenori Watanabe, Masaya Imoto Masato Sawada, Shin-ichiro Kubo, Koji Matsumura, Yasushi Takemoto, Hiroki Kobayashi, Etsu Tashiro, Takeshi Kitahara, Hidenori Watanabe, Masaya Imoto Masato Sawada, Shin-ichiro Kubo, Koji Matsumura, Yasushi Takemoto, Hiroki Kobayashi, Etsu Tashiro, Takeshi Kitahara, Hidenori Watanabe, Masaya Imoto Synthesis and anti-migrative evaluation of moverastin derivatives Synthesis and anti-migrative evaluation of moverastin derivatives Synthesis and anti-migrative evaluation of moverastin derivatives Bioorganic & Medicinal Chemistry Letters, 21, 1385-1389 Bioorganic & Medicinal Chemistry Letters, 21, 1385-1389 Bioorganic & Medicinal Chemistry Letters, 21, 1385-1389 2011/03 Refereed English Research paper(scientific journal) Disclose to all
Yoko Yashiroda, Reika Okamoto, Kaori Hatsugai, Yasushi Takemoto, Naoki Goshima, Tamio Saito, Makiko Hamamoto, Yoshikazu Sugimoto, Hiroyuki Osada, Hiroyuki Seimiya, Minoru Yoshida Yoko Yashiroda, Reika Okamoto, Kaori Hatsugai, Yasushi Takemoto, Naoki Goshima, Tamio Saito, Makiko Hamamoto, Yoshikazu Sugimoto, Hiroyuki Osada, Hiroyuki Seimiya, Minoru Yoshida Yoko Yashiroda, Reika Okamoto, Kaori Hatsugai, Yasushi Takemoto, Naoki Goshima, Tamio Saito, Makiko Hamamoto, Yoshikazu Sugimoto, Hiroyuki Osada, Hiroyuki Seimiya, Minoru Yoshida A novel yeast cell-based screen identifies flavone as a tankyrase inhibitor A novel yeast cell-based screen identifies flavone as a tankyrase inhibitor A novel yeast cell-based screen identifies flavone as a tankyrase inhibitor Biochemical and Biophysical Research Communications, 394, 3, 569-573 Biochemical and Biophysical Research Communications, 394, 3, 569-573 Biochemical and Biophysical Research Communications, 394, 3, 569-573 2010 Refereed English Research paper(scientific journal) Disclose to all
Yasushi Takemoto, Etsu Tashiro, Masaya Imoto Yasushi Takemoto, Etsu Tashiro, Masaya Imoto Yasushi Takemoto, Etsu Tashiro, Masaya Imoto Suppression of Multidrug Resistance by Migrastatin Suppression of Multidrug Resistance by Migrastatin Suppression of Multidrug Resistance by Migrastatin The Journal of Antibiotics, 59, 7, 435-438 The Journal of Antibiotics, 59, 7, 435-438 The Journal of Antibiotics, 59, 7, 435-438 2006 Refereed English Research paper(scientific journal) Disclose to all
Yasushi Takemoto, Hidenori Watanabe, Kenji Uchida, Koji Matsumura, Koichi Nakae, Etsu Tashiro, Kazutoshi Shindo, Takeshi Kitahara, Masaya Imoto Yasushi Takemoto, Hidenori Watanabe, Kenji Uchida, Koji Matsumura, Koichi Nakae, Etsu Tashiro, Kazutoshi Shindo, Takeshi Kitahara, Masaya Imoto Yasushi Takemoto, Hidenori Watanabe, Kenji Uchida, Koji Matsumura, Koichi Nakae, Etsu Tashiro, Kazutoshi Shindo, Takeshi Kitahara, Masaya Imoto Chemistry and Biology of Moverastins, inhibitors of cancer cell migration, produced by Aspergillus Chemistry and Biology of Moverastins, inhibitors of cancer cell migration, produced by Aspergillus Chemistry and Biology of Moverastins, inhibitors of cancer cell migration, produced by Aspergillus Chemistry & Biology, 12, 1337-1347 Chemistry & Biology, 12, 1337-1347 Chemistry & Biology, 12, 1337-1347 2005 Refereed English Research paper(scientific journal) Disclose to all
Yasushi Takemoto, Koichi Nakae, Makoto Kawatani, Yoshikazu Takahashi, Hiroshi Naganawa, Masaya Imoto Yasushi Takemoto, Koichi Nakae, Makoto Kawatani, Yoshikazu Takahashi, Hiroshi Naganawa, Masaya Imoto Yasushi Takemoto, Koichi Nakae, Makoto Kawatani, Yoshikazu Takahashi, Hiroshi Naganawa, Masaya Imoto Migrastatin, a Novel 14-Membered Ring Macrolide, Inhibits Anchorage-independent Growth of Human Small Cell Lung Carcinoma Ms-1 cells Migrastatin, a Novel 14-Membered Ring Macrolide, Inhibits Anchorage-independent Growth of Human Small Cell Lung Carcinoma Ms-1 cells Migrastatin, a Novel 14-Membered Ring Macrolide, Inhibits Anchorage-independent Growth of Human Small Cell Lung Carcinoma Ms-1 cells The Journal of Antibiotics, 54, 12, 1104-1107 The Journal of Antibiotics, 54, 12, 1104-1107 The Journal of Antibiotics, 54, 12, 1104-1107 2001 Refereed English Research paper(scientific journal) Disclose to all

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Title language:
Misc
Author Author(Japanese) Author(English) Title Title(Japanese) Title(English) Bibliography Bibliography(Japanese) Bibliography(English) Publication date Refereed paper Language Publishing type Disclose
竹本靖,伊藤昭博,吉田稔 竹本靖,伊藤昭博,吉田稔 エピジェネティクス制御化合物 エピジェネティクス制御化合物 日本臨牀, 70, 増刊号8, 403-407 日本臨牀, 70, 増刊号8, 403-407 , 70, 増刊号8, 403-407 2012/11 Japanese Introduction and explanation (scientific journal) Disclose to all
竹本靖,伊藤昭博,福田勲,吉田稔 竹本靖,伊藤昭博,福田勲,吉田稔 創薬標的としてのエピジェネティクス制御機構 創薬標的としてのエピジェネティクス制御機構 実験医学, 27, 5, 816-824 実験医学, 27, 5, 816-824 , 27, 5, 816-824 2009/03 Japanese Introduction and explanation (scientific journal) Disclose to all
竹本靖, 井本正哉 竹本靖, 井本正哉 ファルネシルトランスフェラーゼ阻害剤のがん分子標的治療薬への展開 ファルネシルトランスフェラーゼ阻害剤のがん分子標的治療薬への展開 蛋白質 核酸 酵素, 52, 13, 1713-1718 蛋白質 核酸 酵素, 52, 13, 1713-1718 , 52, 13, 1713-1718 2007 Japanese Introduction and explanation (scientific journal) Disclose to all
Title language:
Conference Activities & Talks
Title Title(Japanese) Title(English) Conference Conference(Japanese) Conference(English) Promotor Promotor(Japanese) Promotor(English) Date Language Assortment Disclose
Photo-degradation of squalene synthase by YM-53601 YM-53601によるスクアレン合成酵素の光分解機構の解析 Photo-degradation of squalene synthase by YM-53601 日本ケミカルバイオロジー学会 第14回年会 日本ケミカルバイオロジー学会 第14回年会 2019/06 Japanese Oral presentation(general) Disclose to all
Discovery of “photo-degradation tag of protein” derived from squalene synthase Discovery of “photo-degradation tag of protein” derived from squalene synthase Discovery of “photo-degradation tag of protein” derived from squalene synthase 10th International Peptide Symposium 10th International Peptide Symposium 10th International Peptide Symposium 2018/12 English Oral presentation(general) Disclose to all
YM-53601によるスクアレン合成酵素の光分解機構の解析[Invited] YM-53601によるスクアレン合成酵素の光分解機構の解析 [Invited] 生物機能化学シンポジウム(京都大学エネルギー理工学研究所主催) 生物機能化学シンポジウム(京都大学エネルギー理工学研究所主催) 2018/03/26 Japanese Oral presentation(invited, special) Disclose to all
YM-53601によるスクアレン合成酵素の光分解機構の解析 YM-53601によるスクアレン合成酵素の光分解機構の解析 日本農芸化学会2018年度大会 日本農芸化学会2018年度大会 2018/03/17 Japanese Oral presentation(general) Disclose to all
Title language:
Patents
Inventor(s) Inventor(s) (Japanese) Inventor(s) (English) Title Title(Japanese) Title(English) Stage Patent number Date Disclose
西野憲和,竹本靖,伊藤昭博,吉田稔,矢守隆夫 西野憲和,竹本靖,伊藤昭博,吉田稔,矢守隆夫 タンパク質リシンメチル化酵素Set7/9の阻害物質を含有する疾患の予防・治療剤 タンパク質リシンメチル化酵素Set7/9の阻害物質を含有する疾患の予防・治療剤 特許公開 特開2012-102087 2012/05/31 Disclose to all
西野憲和,竹本靖,伊藤昭博,吉田稔 西野憲和,竹本靖,伊藤昭博,吉田稔 ヒストンメチル化酵素活性の測定法 ヒストンメチル化酵素活性の測定法 特許登録 特許5794659 Disclose to all
Title language:
External funds: competitive funds and Grants-in-Aid for Scientific Research (Kakenhi)
Type Position Title(Japanese) Title(English) Period
若手研究(B) Representative ケミカルジェネティクスに基づいた多能性幹細胞の心筋分化機構の解明 (平成29年度分) 2017/04/01-2018/03/31
若手研究(B) Representative ケミカルジェネティクスに基づいた多能性幹細胞の心筋分化機構の解明 (平成30年度分) 2018/04/01-2019/03/31
Teaching subject(s)
Name(Japanese) Name(English) Term Department Period
生命の有機化学 Organic Chemistry of Life 前期 全学共通科目 2017/04-2018/03
基礎化学実験 Fundamental Chemical Experiments 後期 全学共通科目 2018/04-2019/03
生命の有機化学 Organic Chemistry of Life 前期 全学共通科目 2018/04-2019/03
生命の有機化学 Organic Chemistry of Life 前期 全学共通科目 2019/04-2020/03
Faculty management (title, position)
Title Period
化学研究所広報委員会委員 2016/04/01-2017/03/31
化学研究所総務・教務委員会委員 2019/04/01-2020/03/31