板東 俊和

Last Update: 2018/06/08 09:43:48

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Name(Kanji/Kana/Abecedarium Latinum)
板東 俊和/バンドウ トシカズ/Bando, Toshikazu
Primary Affiliation(Org1/Job title)
Graduate Schools Science/Associate Professor
Faculty
Org1 Job title
理学部
Academic Degree
Field(Japanese) Field(English) University(Japanese) University(English) Method
修士(薬学) 徳島大学
博士(薬学) 徳島大学
Personal Profile
(Japanese)
理学部1、2回生向けに基礎有機化学や生物化学IAの講義を担当し、講義を通じて、DNA,RNA,蛋白質に関連するケミカルバイオロジーや有機化学分野の基礎知識を提供している。また、生物化学研究室の学生に対しては、ケミカルバイオロジーを基盤とする研究指導を通して、社会に通用する研究者としての育成に取り組んでいる。
researchmap URL
https://researchmap.jp/read0099185
Research Topics
(Japanese)
機能性ピロールーイミダゾールポリアミドの設計と合成、その化学的機能評価
(English)
design and synthesis, chemical evaluation for functional pyrrole-imidazole polyamides
Overview of the research
(Japanese)
現在の研究は、従来のCPI-ビニル複合体からCBI-インドール複合体へと設計を改良したことを契機に、より効率的な配列特異的アルキル化剤の実現を目指し、合成と機能評価を中心に進めている。また、CAG繰返配列やテロメア配列などに対する特定配列の検出を可能にする蛍光性ポリアミドの合成と機能評価、特定配列に対するHDAC阻害能によって遺伝子発現を活性化するPy-Im ポリアミド-SAHA (suberoylanilide hydroxamic acid) 誘導体の合成と評価も並行して進めている。細胞生物学的な応用も検討しており、マウスに対する抗がん活性評価と培養がん細胞に対する遺伝子発現解析を実施している。
Fields of research (key words)
Key words(Japanese) Key words(English)
ケミカルバイオロジー chemicalbiology
生物有機合成化学 bioorganic synthesis chemistry
Published Papers
Author Author(Japanese) Author(English) Title Title(Japanese) Title(English) Bibliography Bibliography(Japanese) Bibliography(English) Publication date Refereed paper Language Publishing type Disclose
T. Bando; H. Sugiyama T. Bando; H. Sugiyama The chemical biology that controls DNA function and structure The chemical biology that controls DNA function and structure Yuki Gosei Kagaku Kyokaishi/Journal of Synthetic Organic Chemistry, 63, 10, 1016-1027 Yuki Gosei Kagaku Kyokaishi/Journal of Synthetic Organic Chemistry, 63, 10, 1016-1027 , 63, 10, 1016-1027 2005 Refereed Japanese Disclose to all
M. Yamamoto; T. Bando; H. Morinaga; Y. Kawamoto; K. Hashiya; H. Sugiyama M. Yamamoto; T. Bando; H. Morinaga; Y. Kawamoto; K. Hashiya; H. Sugiyama Sequence-specific DNA recognition by cyclic pyrrole-imidazole cysteine-derived polyamide dimers Sequence-specific DNA recognition by cyclic pyrrole-imidazole cysteine-derived polyamide dimers Chemistry - A European Journal, 20, 3, 752-759 , 20, 3, 752-759 Chemistry - A European Journal, 20, 3, 752-759 2014 Refereed English Disclose to all
G.N. Pandian; J. Taniguchi; S. Junetha; S. Sato; L. Han; A. Saha; C. Anandhakumar; T. Bando; H. Nagase; T. Vaijayanthi; R.D. Taylor; H. Sugiyama G.N. Pandian; J. Taniguchi; S. Junetha; S. Sato; L. Han; A. Saha; C. Anandhakumar; T. Bando; H. Nagase; T. Vaijayanthi; R.D. Taylor; H. Sugiyama Distinct DNA-based epigenetic switches trigger transcriptional activation of silent genes in human dermal fibroblasts Distinct DNA-based epigenetic switches trigger transcriptional activation of silent genes in human dermal fibroblasts Scientific Reports, 4 , 4 Scientific Reports, 4 2014 Refereed English Disclose to all
Y.-W. Han; Y. Tsunaka; H. Yokota; T. Matsumoto; G. Kashiwazaki; H. Morinaga; K. Hashiya; T. Bando; H. Sugiyama; Y. Harada Y.-W. Han; Y. Tsunaka; H. Yokota; T. Matsumoto; G. Kashiwazaki; H. Morinaga; K. Hashiya; T. Bando; H. Sugiyama; Y. Harada Construction and characterization of Cy3- or Cy5-conjugated hairpin pyrrole-imidazole polyamides binding to DNA in the nucleosome Construction and characterization of Cy3- or Cy5-conjugated hairpin pyrrole-imidazole polyamides binding to DNA in the nucleosome Biomaterials Science, 2, 3, 297-307 , 2, 3, 297-307 Biomaterials Science, 2, 3, 297-307 2014 Refereed English Disclose to all
M. Yamamoto; T. Bando; Y. Kawamoto; R.D. Taylor; K. Hashiya; H. Sugiyama M. Yamamoto; T. Bando; Y. Kawamoto; R.D. Taylor; K. Hashiya; H. Sugiyama Specific alkylation of human telomere repeat sequences by a tandem-hairpin motif of pyrrole-imidazole polyamides with indole-seco-CBI Specific alkylation of human telomere repeat sequences by a tandem-hairpin motif of pyrrole-imidazole polyamides with indole-seco-CBI Bioconjugate Chemistry, 25, 3, 552-559 , 25, 3, 552-559 Bioconjugate Chemistry, 25, 3, 552-559 2014 Refereed English Disclose to all
T. Vaijayanthi; T. Bando; K. Hashiya; G.N. Pandian; H. Sugiyama T. Vaijayanthi; T. Bando; K. Hashiya; G.N. Pandian; H. Sugiyama Design of a new fluorescent probe: Pyrrole/imidazole hairpin polyamides with pyrene conjugation at their γ-turn Design of a new fluorescent probe: Pyrrole/imidazole hairpin polyamides with pyrene conjugation at their γ-turn Bioorganic and Medicinal Chemistry, 21, 4, 852-855 , 21, 4, 852-855 Bioorganic and Medicinal Chemistry, 21, 4, 852-855 2013 Refereed English Disclose to all
H. Morinaga; T. Takenaka; F. Hashiya; S. Kizaki; K. Hashiya; T. Bando; H. Sugiyama H. Morinaga; T. Takenaka; F. Hashiya; S. Kizaki; K. Hashiya; T. Bando; H. Sugiyama Sequence-specific electron injection into DNA from an intermolecular electron donor Sequence-specific electron injection into DNA from an intermolecular electron donor Nucleic Acids Research, 41, 8, 4724-4728 , 41, 8, 4724-4728 Nucleic Acids Research, 41, 8, 4724-4728 2013 Refereed English Disclose to all
A. Saha; G.N. Pandian; S. Sato; J. Taniguchi; K. Hashiya; T. Bando; H. Sugiyama A. Saha; G.N. Pandian; S. Sato; J. Taniguchi; K. Hashiya; T. Bando; H. Sugiyama Synthesis and biological evaluation of a targeted DNA-binding transcriptional activator with HDAC8 inhibitory activity Synthesis and biological evaluation of a targeted DNA-binding transcriptional activator with HDAC8 inhibitory activity Bioorganic and Medicinal Chemistry, 21, 14, 4201-4209 , 21, 14, 4201-4209 Bioorganic and Medicinal Chemistry, 21, 14, 4201-4209 2013 Refereed English Disclose to all
A. Iguchi; N. Fukuda; T. Takahashi; T. Watanabe; H. Matsuda; H. Nagase; T. Bando; H. Sugiyama; K. Shimizu A. Iguchi; N. Fukuda; T. Takahashi; T. Watanabe; H. Matsuda; H. Nagase; T. Bando; H. Sugiyama; K. Shimizu RNA binding properties of novel gene silencing pyrrole-imidazole polyamides RNA binding properties of novel gene silencing pyrrole-imidazole polyamides Biological and Pharmaceutical Bulletin, 36, 7, 1152-1158 , 36, 7, 1152-1158 Biological and Pharmaceutical Bulletin, 36, 7, 1152-1158 2013 Refereed English Disclose to all
Y.-W. Han; G. Kashiwazaki; H. Morinaga; T. Matsumoto; K. Hashiya; T. Bando; Y. Harada; H. Sugiyama Y.-W. Han; G. Kashiwazaki; H. Morinaga; T. Matsumoto; K. Hashiya; T. Bando; Y. Harada; H. Sugiyama Effect of single pyrrole replacement with β-alanine on DNA binding affinity and sequence specificity of hairpin pyrrole/imidazole polyamides targeting 5′-GCGC-3′ Effect of single pyrrole replacement with β-alanine on DNA binding affinity and sequence specificity of hairpin pyrrole/imidazole polyamides targeting 5′-GCGC-3′ Bioorganic and Medicinal Chemistry, 21, 17, 5436-5441 , 21, 17, 5436-5441 Bioorganic and Medicinal Chemistry, 21, 17, 5436-5441 2013 Refereed English Disclose to all
Y. Kawamoto; T. Bando; F. Kamada; Y. Li; K. Hashiya; K. Maeshima; H. Sugiyama Y. Kawamoto; T. Bando; F. Kamada; Y. Li; K. Hashiya; K. Maeshima; H. Sugiyama Development of a new method for synthesis of tandem hairpin pyrrole-imidazole polyamide probes targeting human telomeres Development of a new method for synthesis of tandem hairpin pyrrole-imidazole polyamide probes targeting human telomeres Journal of the American Chemical Society, 135, 44, 16468-16477 , 135, 44, 16468-16477 Journal of the American Chemical Society, 135, 44, 16468-16477 2013 Refereed English Disclose to all
L. Han; G.N. Pandian; S. Junetha; S. Sato; C. Anandhakumar; J. Taniguchi; A. Saha; T. Bando; H. Nagase; H. Sugiyama L. Han; G.N. Pandian; S. Junetha; S. Sato; C. Anandhakumar; J. Taniguchi; A. Saha; T. Bando; H. Nagase; H. Sugiyama A synthetic small molecule for targeted transcriptional activation of germ cell genes in a human somatic cell A synthetic small molecule for targeted transcriptional activation of germ cell genes in a human somatic cell Angewandte Chemie - International Edition, 52, 50, 13410-13413 , 52, 50, 13410-13413 Angewandte Chemie - International Edition, 52, 50, 13410-13413 2013 Refereed English Disclose to all
Y.-W. Han; T. Matsumoto; H. Yokota; G. Kashiwazaki; H. Morinaga; K. Hashiya; T. Bando; Y. Harada; H. Sugiyama Y.-W. Han; T. Matsumoto; H. Yokota; G. Kashiwazaki; H. Morinaga; K. Hashiya; T. Bando; Y. Harada; H. Sugiyama Binding of hairpin pyrrole and imidazole polyamides to DNA: Relationship between torsion angle and association rate constants Binding of hairpin pyrrole and imidazole polyamides to DNA: Relationship between torsion angle and association rate constants Nucleic Acids Research, 40, 22, 11510-11517 , 40, 22, 11510-11517 Nucleic Acids Research, 40, 22, 11510-11517 2012/12 Refereed English Disclose to all
G.N. Pandian; Y. Nakano; S. Sato; H. Morinaga; T. Bando; H. Nagase; H. Sugiyama G.N. Pandian; Y. Nakano; S. Sato; H. Morinaga; T. Bando; H. Nagase; H. Sugiyama A synthetic small molecule for rapid induction of multiple pluripotency genes in mouse embryonic fibroblasts A synthetic small molecule for rapid induction of multiple pluripotency genes in mouse embryonic fibroblasts Scientific Reports, 2 , 2 Scientific Reports, 2 2012/07/30 Refereed English Disclose to all
T. Yoshidome; M. Endo; G. Kashiwazaki; K. Hidaka; T. Bando; H. Sugiyama T. Yoshidome; M. Endo; G. Kashiwazaki; K. Hidaka; T. Bando; H. Sugiyama Sequence-selective single-molecule alkylation with a pyrrole-imidazole polyamide visualized in a DNA nanoscaffold Sequence-selective single-molecule alkylation with a pyrrole-imidazole polyamide visualized in a DNA nanoscaffold Journal of the American Chemical Society, 134, 10, 4654-4660 , 134, 10, 4654-4660 Journal of the American Chemical Society, 134, 10, 4654-4660 2012/03/14 Refereed English Disclose to all
G. Kashiwazaki; T. Bando; T. Yoshidome; S. Masui; T. Takagaki; K. Hashiya; G.N. Pandian; J. Yasuoka; K. Akiyoshi; H. Sugiyama G. Kashiwazaki; T. Bando; T. Yoshidome; S. Masui; T. Takagaki; K. Hashiya; G.N. Pandian; J. Yasuoka; K. Akiyoshi; H. Sugiyama Synthesis and biological properties of highly sequence-specific-alkylating N-methylpyrrole- N -methylimidazole polyamide conjugates Synthesis and biological properties of highly sequence-specific-alkylating N-methylpyrrole- N -methylimidazole polyamide conjugates Journal of Medicinal Chemistry, 55, 5, 2057-2066 , 55, 5, 2057-2066 Journal of Medicinal Chemistry, 55, 5, 2057-2066 2012/03/08 Refereed English Disclose to all
G.N. Pandian; A. Ohtsuki; T. Bando; S. Sato; K. Hashiya; H. Sugiyama G.N. Pandian; A. Ohtsuki; T. Bando; S. Sato; K. Hashiya; H. Sugiyama Development of programmable small DNA-binding molecules with epigenetic activity for induction of core pluripotency genes Development of programmable small DNA-binding molecules with epigenetic activity for induction of core pluripotency genes Bioorganic and Medicinal Chemistry, 20, 8, 2656-2660 , 20, 8, 2656-2660 Bioorganic and Medicinal Chemistry, 20, 8, 2656-2660 2012 Refereed English Disclose to all
T. Takagaki; T. Bando; H. Sugiyama T. Takagaki; T. Bando; H. Sugiyama Synthesis of pyrrole-imidazole polyamide seco -1-chloromethyl-5-hydroxy-1, 2-dihydro-3 H -benz[ e ]indole conjugates with a vinyl linker recognizing a 7 bp DNA sequence Synthesis of pyrrole-imidazole polyamide seco -1-chloromethyl-5-hydroxy-1, 2-dihydro-3 H -benz[ e ]indole conjugates with a vinyl linker recognizing a 7 bp DNA sequence Journal of the American Chemical Society, 134, 31, 13074-13081 , 134, 31, 13074-13081 Journal of the American Chemical Society, 134, 31, 13074-13081 2012 Refereed English Disclose to all
T. Vaijayanthi; T. Bando; G.N. Pandian; H. Sugiyama T. Vaijayanthi; T. Bando; G.N. Pandian; H. Sugiyama Progress and Prospects of Pyrrole-Imidazole Polyamide-Fluorophore Conjugates as Sequence-Selective DNA Probes Progress and Prospects of Pyrrole-Imidazole Polyamide-Fluorophore Conjugates as Sequence-Selective DNA Probes ChemBioChem, 13, 15, 2170-2185 , 13, 15, 2170-2185 ChemBioChem, 13, 15, 2170-2185 2012 Refereed English Disclose to all
Takagaki, T; Bando, T.*; Sugiyama, H.
 Takagaki, T; Bando, T.*; Sugiyama, H.
 Synthesis of Pyrrole-Imidazole Polyamide Seco-CBI Conjugates with a Vinyl Linker recognizing 7 bp DNA sequence. Synthesis of Pyrrole-Imidazole Polyamide Seco-CBI Conjugates with a Vinyl Linker recognizing 7 bp DNA sequence. J. Am. Chem. Soc., 2012, 134, 13074-13081, 134, 31, 13074-13081 , 134, 31, 13074-13081 J. Am. Chem. Soc., 2012, 134, 13074-13081, 134, 31, 13074-13081 2012 Refereed English Disclose to all
G.N. Pandian; K.-I. Shinohara; A. Ohtsuki; Y. Nakano; M. Masafumi; T. Bando; H. Nagase; Y. Yamada; A. Watanabe; N. Terada; S. Sato; H. Morinaga; H. Sugiyama G.N. Pandian; K.-I. Shinohara; A. Ohtsuki; Y. Nakano; M. Masafumi; T. Bando; H. Nagase; Y. Yamada; A. Watanabe; N. Terada; S. Sato; H. Morinaga; H. Sugiyama Synthetic small molecules for epigenetic activation of pluripotency genes in mouse embryonic fibroblasts Synthetic small molecules for epigenetic activation of pluripotency genes in mouse embryonic fibroblasts ChemBioChem, 12, 18, 2822-2828 , 12, 18, 2822-2828 ChemBioChem, 12, 18, 2822-2828 2011/12/16 Refereed English Disclose to all
A. Yasuda; K. Noguchi; M. Minoshima; G. Kashiwazaki; T. Kanda; K. Katayama; J. Mitsuhashi; T. Bando; H. Sugiyama; Y. Sugimoto A. Yasuda; K. Noguchi; M. Minoshima; G. Kashiwazaki; T. Kanda; K. Katayama; J. Mitsuhashi; T. Bando; H. Sugiyama; Y. Sugimoto DNA ligand designed to antagonize EBNA1 represses Epstein-Barr virus-induced immortalization DNA ligand designed to antagonize EBNA1 represses Epstein-Barr virus-induced immortalization Cancer Science, 102, 12, 2221-2230 , 102, 12, 2221-2230 Cancer Science, 102, 12, 2221-2230 2011/12 Refereed English Disclose to all
H. Morinaga; T. Bando; T. Takagaki; M. Yamamoto; K. Hashiya H. Morinaga; T. Bando; T. Takagaki; M. Yamamoto; K. Hashiya Cysteine cyclic pyrrole-imidazole polyamide for sequence-specific recognition in the DNA minor groove Cysteine cyclic pyrrole-imidazole polyamide for sequence-specific recognition in the DNA minor groove Journal of the American Chemical Society, 133, 46, 18924-18930 , 133, 46, 18924-18930 Journal of the American Chemical Society, 133, 46, 18924-18930 2011/11/23 Refereed English Disclose to all
T. Takagaki; T. Bando; M. Kitano; K. Hashiya; G. Kashiwazaki; H. Sugiyama T. Takagaki; T. Bando; M. Kitano; K. Hashiya; G. Kashiwazaki; H. Sugiyama Evaluation of PI polyamide conjugates with eight-base pair recognition and improvement of the aqueous solubility by PEGylation Evaluation of PI polyamide conjugates with eight-base pair recognition and improvement of the aqueous solubility by PEGylation Bioorganic and Medicinal Chemistry, 19, 19, 5896-5902 , 19, 19, 5896-5902 Bioorganic and Medicinal Chemistry, 19, 19, 5896-5902 2011/10/01 Refereed English Disclose to all
S. Park; T. Bando; K.-I. Shinohara; S. Nishijima; H. Sugiyama S. Park; T. Bando; K.-I. Shinohara; S. Nishijima; H. Sugiyama Photocontrollable sequence-specific DNA alkylation by a pyrrole-imidazole polyamide seco-CBI conjugate Photocontrollable sequence-specific DNA alkylation by a pyrrole-imidazole polyamide seco-CBI conjugate Bioconjugate Chemistry, 22, 2, 120-124 , 22, 2, 120-124 Bioconjugate Chemistry, 22, 2, 120-124 2011/02 Refereed English Disclose to all
H. Matsuda; N. Fukuda; T. Ueno; M. Katakawa; X. Wang; T. Watanabe; S.-I. Matsui; T. Aoyama; K. Saito; T. Bando; Y. Matsumoto; H. Nagase; K. Matsumoto; H. Sugiyama H. Matsuda; N. Fukuda; T. Ueno; M. Katakawa; X. Wang; T. Watanabe; S.-I. Matsui; T. Aoyama; K. Saito; T. Bando; Y. Matsumoto; H. Nagase; K. Matsumoto; H. Sugiyama Transcriptional inhibition of progressive renal disease by gene silencing pyrrole-imidazole polyamide targeting of the transforming growth factor-Β1 promoter Transcriptional inhibition of progressive renal disease by gene silencing pyrrole-imidazole polyamide targeting of the transforming growth factor-Β1 promoter Kidney International, 79, 1, 46-56 , 79, 1, 46-56 Kidney International, 79, 1, 46-56 2011 Refereed English Disclose to all
Matsuda, H.; Fukuda, N.; Ueno, T.; Katakawa, M.; Wang, X.; Watanabe, T.; Matsui, S.; Aoyama, T.; Saito, K.; Bando, T.; Matsumoto, Y.; Nagase, H.; Matsumoto, K.; Sugiyama, H. Matsuda, H.; Fukuda, N.; Ueno, T.; Katakawa, M.; Wang, X.; Watanabe, T.; Matsui, S.; Aoyama, T.; Saito, K.; Bando, T.; Matsumoto, Y.; Nagase, H.; Matsumoto, K.; Sugiyama, H. Transcriptional Inhibition of Progressive Renal Disease by the Gene Silencing Pyrrole-Imidazole polyamide Targeted to the TGF-b1 Promoter. Transcriptional Inhibition of Progressive Renal Disease by the Gene Silencing Pyrrole-Imidazole polyamide Targeted to the TGF-b1 Promoter. Kidney International., 79, 46-56., 79, 1, 46-56 , 79, 1, 46-56 Kidney International., 79, 46-56., 79, 1, 46-56 2011 Refereed English Disclose to all
G. Kashiwazaki; T. Bando; K.-i. Shinohara; M. Minoshima; H. Kumamoto; S. Nishijima; H. Sugiyama G. Kashiwazaki; T. Bando; K.-i. Shinohara; M. Minoshima; H. Kumamoto; S. Nishijima; H. Sugiyama Alkylation of a human telomere sequence by heterotrimeric chlorambucil PI polyamide conjugates Alkylation of a human telomere sequence by heterotrimeric chlorambucil PI polyamide conjugates Bioorganic and Medicinal Chemistry, 18, 8, 2887-2893 , 18, 8, 2887-2893 Bioorganic and Medicinal Chemistry, 18, 8, 2887-2893 2010/04/15 Refereed English Disclose to all
K.-I. Shinohara; Y. Sannohe; S. Kaieda; K.-I. Tanaka; H. Osuga; H. Tahara; Y. Xu; T. Kawase; T. Bando; H. Sugiyama K.-I. Shinohara; Y. Sannohe; S. Kaieda; K.-I. Tanaka; H. Osuga; H. Tahara; Y. Xu; T. Kawase; T. Bando; H. Sugiyama A chiral wedge molecule inhibits telomerase activity A chiral wedge molecule inhibits telomerase activity Journal of the American Chemical Society, 132, 11, 3778-3782 , 132, 11, 3778-3782 Journal of the American Chemical Society, 132, 11, 3778-3782 2010/03/24 Refereed English Disclose to all
K.-I. Shinohara; T. Bando; H. Sugiyama K.-I. Shinohara; T. Bando; H. Sugiyama Anticancer activities of alkylating pyrrole-imidazole polyamides with specific sequence recognition Anticancer activities of alkylating pyrrole-imidazole polyamides with specific sequence recognition Anti-Cancer Drugs, 21, 3, 228-242 , 21, 3, 228-242 Anti-Cancer Drugs, 21, 3, 228-242 2010/03 Refereed English Disclose to all
M. Minoshima; T. Bando; K.-i. Shinohara; G. Kashiwazaki; S. Nishijima; H. Sugiyama M. Minoshima; T. Bando; K.-i. Shinohara; G. Kashiwazaki; S. Nishijima; H. Sugiyama Comparative analysis of DNA alkylation by conjugates between pyrrole-imidazole hairpin polyamides and chlorambucil or seco-CBI Comparative analysis of DNA alkylation by conjugates between pyrrole-imidazole hairpin polyamides and chlorambucil or seco-CBI Bioorganic and Medicinal Chemistry, 18, 3, 1236-1243 , 18, 3, 1236-1243 Bioorganic and Medicinal Chemistry, 18, 3, 1236-1243 2010/02/01 Refereed English Disclose to all
S. Nishijima; K.-i. Shinohara; T. Bando; M. Minoshima; G. Kashiwazaki; H. Sugiyama S. Nishijima; K.-i. Shinohara; T. Bando; M. Minoshima; G. Kashiwazaki; H. Sugiyama Cell permeability of Py-Im-polyamide-fluorescein conjugates: Influence of molecular size and Py/Im content Cell permeability of Py-Im-polyamide-fluorescein conjugates: Influence of molecular size and Py/Im content Bioorganic and Medicinal Chemistry, 18, 2, 978-983 , 18, 2, 978-983 Bioorganic and Medicinal Chemistry, 18, 2, 978-983 2010/01/15 Refereed English Disclose to all
M. Minoshima; J.C. Chou; S. Lefebvre; T. Bando; K.-i. Shinohara; J.M. Gottesfeld; H. Sugiyama M. Minoshima; J.C. Chou; S. Lefebvre; T. Bando; K.-i. Shinohara; J.M. Gottesfeld; H. Sugiyama Potent activity against K562 cells by polyamide-seco-CBI conjugates targeting histone H4 genes Potent activity against K562 cells by polyamide-seco-CBI conjugates targeting histone H4 genes Bioorganic and Medicinal Chemistry, 18, 1, 168-174 , 18, 1, 168-174 Bioorganic and Medicinal Chemistry, 18, 1, 168-174 2010/01/01 Refereed English Disclose to all
A. Ohtsuki; M.T. Kimura; M. Minoshima; T. Suzuki; M. Ikeda; T. Bando; H. Nagase; K.-i. Shinohara; H. Sugiyama A. Ohtsuki; M.T. Kimura; M. Minoshima; T. Suzuki; M. Ikeda; T. Bando; H. Nagase; K.-i. Shinohara; H. Sugiyama Synthesis and properties of PI polyamide-SAHA conjugate Synthesis and properties of PI polyamide-SAHA conjugate Tetrahedron Letters, 50, 52, 7288-7292 , 50, 52, 7288-7292 Tetrahedron Letters, 50, 52, 7288-7292 2009/12/30 Refereed English Disclose to all
K. Kino; K. Sugasawa; T. Mizuno; T. Bando; H. Sugiyama; M. Akita; H. Miyazawa; F. Hanaoka K. Kino; K. Sugasawa; T. Mizuno; T. Bando; H. Sugiyama; M. Akita; H. Miyazawa; F. Hanaoka Eukaryotic DNA polymerases α, β and ε incorporate guanine opposite 2,2,4-triamino-5(2H)-oxazolone Eukaryotic DNA polymerases α, β and ε incorporate guanine opposite 2,2,4-triamino-5(2H)-oxazolone ChemBioChem, 10, 16, 2613-2616 , 10, 16, 2613-2616 ChemBioChem, 10, 16, 2613-2616 2009/11/02 Refereed English Disclose to all
T. Suzuki; Y. Asami; T. Takahashi; X. Wang; T. Watanabe; T. Bando; H. Sugiyama; N. Fukuda; H. Nagase T. Suzuki; Y. Asami; T. Takahashi; X. Wang; T. Watanabe; T. Bando; H. Sugiyama; N. Fukuda; H. Nagase Development of a molecule-recognized promoter DNA sequence for inhibition of HER2 expression Development of a molecule-recognized promoter DNA sequence for inhibition of HER2 expression Journal of Antibiotics, 62, 6, 339-341 , 62, 6, 339-341 Journal of Antibiotics, 62, 6, 339-341 2009/06 Refereed English Disclose to all
G. Kashiwazaki; T. Bando; K.-i. Shinohara; M. Minoshima; S. Nishijima; H. Sugiyama G. Kashiwazaki; T. Bando; K.-i. Shinohara; M. Minoshima; S. Nishijima; H. Sugiyama Cooperative alkylation of double-strand human telomere repeat sequences by PI polyamides with 11-base-pair recognition based on a heterotrimeric design Cooperative alkylation of double-strand human telomere repeat sequences by PI polyamides with 11-base-pair recognition based on a heterotrimeric design Bioorganic and Medicinal Chemistry, 17, 3, 1393-1397 , 17, 3, 1393-1397 Bioorganic and Medicinal Chemistry, 17, 3, 1393-1397 2009/02/01 Refereed English Disclose to all
T. Suzuki; Y. Asami; T. Takahashi; X. Wang; T. Watanabe; T. Bando; H. Sugiyama; N. Fukuda; H. Nagase T. Suzuki; Y. Asami; T. Takahashi; X. Wang; T. Watanabe; T. Bando; H. Sugiyama; N. Fukuda; H. Nagase Erratum: Development of a molecule-recognized promoter DNA sequence for inhibition of HER2 expression (The Journal of Antibiotics (2009) 62 (345) doi:10.1038/ja.2009.42)) Erratum: Development of a molecule-recognized promoter DNA sequence for inhibition of HER2 expression (The Journal of Antibiotics (2009) 62 (345) doi:10.1038/ja.2009.42)) Journal of Antibiotics, 62, 6, 345- , 62, 6, 345- Journal of Antibiotics, 62, 6, 345- 2009 Refereed English Disclose to all
S. Sasaki; T. Bando; M. Minoshima; K.-I. Shinohara; H. Sugiyama S. Sasaki; T. Bando; M. Minoshima; K.-I. Shinohara; H. Sugiyama Sequence-specific alkylation by Y-shaped and tandem hairpin pyrrole-imidazole polyamides Sequence-specific alkylation by Y-shaped and tandem hairpin pyrrole-imidazole polyamides Chemistry - A European Journal, 14, 3, 864-870 , 14, 3, 864-870 Chemistry - A European Journal, 14, 3, 864-870 2008 Refereed English Disclose to all
T. Bando; M. Minoshima; G. Kashiwazaki; K.-i. Shinohara; S. Sasaki; J. Fujimoto; A. Ohtsuki; M. Murakami; S. Nakazono; H. Sugiyama T. Bando; M. Minoshima; G. Kashiwazaki; K.-i. Shinohara; S. Sasaki; J. Fujimoto; A. Ohtsuki; M. Murakami; S. Nakazono; H. Sugiyama Requirement of β-alanine components in sequence-specific DNA alkylation by pyrrole-imidazole conjugates with seven-base pair recognition Requirement of β-alanine components in sequence-specific DNA alkylation by pyrrole-imidazole conjugates with seven-base pair recognition Bioorganic and Medicinal Chemistry, 16, 5, 2286-2291 , 16, 5, 2286-2291 Bioorganic and Medicinal Chemistry, 16, 5, 2286-2291 2008 Refereed English Disclose to all
M. Minoshima; T. Bando; S. Sasaki; J. Fujimoto; H. Sugiyama M. Minoshima; T. Bando; S. Sasaki; J. Fujimoto; H. Sugiyama Pyrrole-imidazole hairpin polyamides with high affinity at 5′-CGCG-3′ DNA sequence; influence of cytosine methylation on binding Pyrrole-imidazole hairpin polyamides with high affinity at 5′-CGCG-3′ DNA sequence; influence of cytosine methylation on binding Nucleic Acids Research, 36, 9, 2889-2894 , 36, 9, 2889-2894 Nucleic Acids Research, 36, 9, 2889-2894 2008 Refereed English Disclose to all
J. Fujimoto; T. Bando; M. Minoshima; S. Uchida; M. Iwasaki; K.-i. Shinohara; H. Sugiyama J. Fujimoto; T. Bando; M. Minoshima; S. Uchida; M. Iwasaki; K.-i. Shinohara; H. Sugiyama Detection of triplet repeat sequences in the double-stranded DNA using pyrene-functionalized pyrrole-imidazole polyamides with rigid linkers Detection of triplet repeat sequences in the double-stranded DNA using pyrene-functionalized pyrrole-imidazole polyamides with rigid linkers Bioorganic and Medicinal Chemistry, 16, 11, 5899-5907 , 16, 11, 5899-5907 Bioorganic and Medicinal Chemistry, 16, 11, 5899-5907 2008 Refereed English Disclose to all
T. Takahashi; Y. Asami; E. Kitamura; T. Suzuki; X. Wang; J. Igarashi; A. Morohashi; Y. Shinojima; H. Kanou; K. Saito; T. Takasu; H. Nagase; Y. Harada; K. Kuroda; T. Watanabe; S. Kumamoto; T. Aoyama; Y. Matsumoto; T. Bando; H. Sugiyama; C. Yoshida-Noro; N. Fukuda; N. Hayashi T. Takahashi; Y. Asami; E. Kitamura; T. Suzuki; X. Wang; J. Igarashi; A. Morohashi; Y. Shinojima; H. Kanou; K. Saito; T. Takasu; H. Nagase; Y. Harada; K. Kuroda; T. Watanabe; S. Kumamoto; T. Aoyama; Y. Matsumoto; T. Bando; H. Sugiyama; C. Yoshida-Noro; N. Fukuda; N. Hayashi Development of Pyrrole-Imidazole Polyamide for Specific Regulation of Human Aurora Kinase-A and -B Gene Expression Development of Pyrrole-Imidazole Polyamide for Specific Regulation of Human Aurora Kinase-A and -B Gene Expression Chemistry and Biology, 15, 8, 829-841 , 15, 8, 829-841 Chemistry and Biology, 15, 8, 829-841 2008 Refereed English Disclose to all
J. Fujimoto; T. Bando; M. Minoshima; G. Kashiwazaki; S. Nishijima; K.-i. Shinohara; H. Sugiyama J. Fujimoto; T. Bando; M. Minoshima; G. Kashiwazaki; S. Nishijima; K.-i. Shinohara; H. Sugiyama Perylene-conjugated pyrrole polyamide as a sequence-specific fluorescent probe Perylene-conjugated pyrrole polyamide as a sequence-specific fluorescent probe Bioorganic and Medicinal Chemistry, 16, 22, 9741-9744 , 16, 22, 9741-9744 Bioorganic and Medicinal Chemistry, 16, 22, 9741-9744 2008 Refereed English Disclose to all
M. Minoshima; T. Bando; S. Sasaki; K.-I. Shinohara; T. Shimizu; J. Fujimoto; H. Sugiyama M. Minoshima; T. Bando; S. Sasaki; K.-I. Shinohara; T. Shimizu; J. Fujimoto; H. Sugiyama DNA alkylation by pyrrole-imidazole seco-CBI conjugates with an indole linker: Sequence-specific DNA alkylation with 10-base-pair recognition through heterodimer formation DNA alkylation by pyrrole-imidazole seco-CBI conjugates with an indole linker: Sequence-specific DNA alkylation with 10-base-pair recognition through heterodimer formation Journal of the American Chemical Society, 129, 17, 5384-5390 , 129, 17, 5384-5390 Journal of the American Chemical Society, 129, 17, 5384-5390 2007 Refereed English Disclose to all
T. Bando; J. Fujimoto; M. Minoshima; K.-i. Shinohara; S. Sasaki; G. Kashiwazaki; M. Mizumura; H. Sugiyama T. Bando; J. Fujimoto; M. Minoshima; K.-i. Shinohara; S. Sasaki; G. Kashiwazaki; M. Mizumura; H. Sugiyama Detection of CAG repeat DNA sequences by pyrene-functionalized pyrrole-imidazole polyamides Detection of CAG repeat DNA sequences by pyrene-functionalized pyrrole-imidazole polyamides Bioorganic and Medicinal Chemistry, 15, 22, 6937-6942 , 15, 22, 6937-6942 Bioorganic and Medicinal Chemistry, 15, 22, 6937-6942 2007 Refereed English Disclose to all
K.-I. Shinohara; S. Sasaki; M. Minoshima; T. Bando; H. Sugiyama K.-I. Shinohara; S. Sasaki; M. Minoshima; T. Bando; H. Sugiyama Alkylation of template strand of coding region causes effective gene silencing Alkylation of template strand of coding region causes effective gene silencing Nucleic Acids Research, 34, 4, 1189-1195 , 34, 4, 1189-1195 Nucleic Acids Research, 34, 4, 1189-1195 2006 Refereed English Disclose to all
H. Matsuda; N. Fukuda; T. Ueno; Y. Tahira; H. Ayame; W. Zhang; T. Bando; H. Sugiyama; S. Saito; K. Matsumoto; H. Mugishima; K. Serie H. Matsuda; N. Fukuda; T. Ueno; Y. Tahira; H. Ayame; W. Zhang; T. Bando; H. Sugiyama; S. Saito; K. Matsumoto; H. Mugishima; K. Serie Development of gene silencing pyrrole-imidazole polyamide targeting the TGF-β1 promoter for treatment of progressive renal diseases Development of gene silencing pyrrole-imidazole polyamide targeting the TGF-β1 promoter for treatment of progressive renal diseases Journal of the American Society of Nephrology, 17, 2, 422-432 , 17, 2, 422-432 Journal of the American Society of Nephrology, 17, 2, 422-432 2006 Refereed English Disclose to all
K.-I. Shinohara; T. Bando; S. Sasaki; Y. Sakakibara; M. Minoshima; H. Sugiyama K.-I. Shinohara; T. Bando; S. Sasaki; Y. Sakakibara; M. Minoshima; H. Sugiyama Antitumor activity of sequence-specific alkylating agents: Pyrolle-imidazole CBI conjugates with indole linker Antitumor activity of sequence-specific alkylating agents: Pyrolle-imidazole CBI conjugates with indole linker Cancer Science, 97, 3, 219-225 , 97, 3, 219-225 Cancer Science, 97, 3, 219-225 2006 Refereed English Disclose to all
T. Bando; S. Sasaki; M. Minoshima; C. Dohno; K.-I. Shinohara; A. Narita; H. Sugiyama T. Bando; S. Sasaki; M. Minoshima; C. Dohno; K.-I. Shinohara; A. Narita; H. Sugiyama Efficient DNA alkylation by a pyrrole-imidazole cbi conjugate with an indole linker: Sequence-specific alkylation with nine-base-pair recognition Efficient DNA alkylation by a pyrrole-imidazole cbi conjugate with an indole linker: Sequence-specific alkylation with nine-base-pair recognition Bioconjugate Chemistry, 17, 3, 715-720 , 17, 3, 715-720 Bioconjugate Chemistry, 17, 3, 715-720 2006 Refereed English Disclose to all
W. Zhang; T. Bando; H. Sugiyama W. Zhang; T. Bando; H. Sugiyama Discrimination of hairpin polyamides with an α-substituted-γ- aminobutyric acid as a 5′-TG-3′ reader in DNA minor groove Discrimination of hairpin polyamides with an α-substituted-γ- aminobutyric acid as a 5′-TG-3′ reader in DNA minor groove Journal of the American Chemical Society, 128, 27, 8766-8776 , 128, 27, 8766-8776 Journal of the American Chemical Society, 128, 27, 8766-8776 2006 Refereed English Disclose to all
S. Sasaki; T. Bando; M. Minoshima; T. Shimizu; K.-I. Shinohara; T. Takaoka; H. Sugiyama S. Sasaki; T. Bando; M. Minoshima; T. Shimizu; K.-I. Shinohara; T. Takaoka; H. Sugiyama Sequence-specific alkylation of double-strand human telomere repeat sequence by pyrrole-imidazole polyamides with indole linkers Sequence-specific alkylation of double-strand human telomere repeat sequence by pyrrole-imidazole polyamides with indole linkers Journal of the American Chemical Society, 128, 37, 12162-12168 , 128, 37, 12162-12168 Journal of the American Chemical Society, 128, 37, 12162-12168 2006 Refereed English Disclose to all
T. Bando; H. Sugiyama T. Bando; H. Sugiyama Synthesis and biological properties of sequence-specific DNA-alkylating pyrrole-imidazole polyamides Synthesis and biological properties of sequence-specific DNA-alkylating pyrrole-imidazole polyamides Accounts of Chemical Research, 39, 12, 935-944 , 39, 12, 935-944 Accounts of Chemical Research, 39, 12, 935-944 2006 Refereed English Disclose to all
T. Watanabe; T. Bando; Y. Xu; R. Tashiro; H. Sugiyama T. Watanabe; T. Bando; Y. Xu; R. Tashiro; H. Sugiyama Efficient generation of 2′-deoxyuridin-5-yl at 5′-(G/C)AA <sup>x</sup>U<sup>x</sup>U-3′ (X = Br, I) sequences in duplex DNA under UV irradiation Efficient generation of 2′-deoxyuridin-5-yl at 5′-(G/C)AA <sup>x</sup>U<sup>x</sup>U-3′ (X = Br, I) sequences in duplex DNA under UV irradiation Journal of the American Chemical Society, 127, 1, 44-45 , 127, 1, 44-45 Journal of the American Chemical Society, 127, 1, 44-45 2005 Refereed English Disclose to all
T. Bando; A. Narita; S. Sasaki; H. Sugiyama T. Bando; A. Narita; S. Sasaki; H. Sugiyama Specific adenine alkylation by pyrrole-imidazole CBI conjugates Specific adenine alkylation by pyrrole-imidazole CBI conjugates Journal of the American Chemical Society, 127, 40, 13890-13895 , 127, 40, 13890-13895 Journal of the American Chemical Society, 127, 40, 13890-13895 2005 Refereed English Disclose to all
Y.-M. Lai; N. Fukuda; T. Ueno; H. Matsuda; S. Saito; K. Matsumoto; H. Ayame; T. Bando; H. Sugiyama; H. Mugishima; K. Serie Y.-M. Lai; N. Fukuda; T. Ueno; H. Matsuda; S. Saito; K. Matsumoto; H. Ayame; T. Bando; H. Sugiyama; H. Mugishima; K. Serie Synthetic pyrrole-imidazole polyamide inhibits expression of the human transforming growth factor-β1 gene Synthetic pyrrole-imidazole polyamide inhibits expression of the human transforming growth factor-β1 gene Journal of Pharmacology and Experimental Therapeutics, 315, 2, 571-575 , 315, 2, 571-575 Journal of Pharmacology and Experimental Therapeutics, 315, 2, 571-575 2005 Refereed English Disclose to all
T. Yoshimura; T. Bando; M. Shindo; K. Shishido T. Yoshimura; T. Bando; M. Shindo; K. Shishido Diastereoselective synthesis of the 19-epi-C <sub>18</sub>-C <sub>25</sub> segment of (-)-lasonolide a and an unusual inversion at C <sub>19</sub> Diastereoselective synthesis of the 19-epi-C <sub>18</sub>-C <sub>25</sub> segment of (-)-lasonolide a and an unusual inversion at C <sub>19</sub> Tetrahedron Letters, 45, 50, 9241-9244 , 45, 50, 9241-9244 Tetrahedron Letters, 45, 50, 9241-9244 2004/12/06 Refereed English Disclose to all
T. Bando; A. Narita; A. Iwai; K. Kihara; H. Sugiyama T. Bando; A. Narita; A. Iwai; K. Kihara; H. Sugiyama C-H to N Substitution Dramatically Alters the Sequence-Specific DNA Alkylation, Cytotoxicity, and Expression of Human Cancer Cell Lines C-H to N Substitution Dramatically Alters the Sequence-Specific DNA Alkylation, Cytotoxicity, and Expression of Human Cancer Cell Lines Journal of the American Chemical Society, 126, 11, 3406-3407 , 126, 11, 3406-3407 Journal of the American Chemical Society, 126, 11, 3406-3407 2004 Refereed English Disclose to all
K.-I. Shinohara; A. Narita; T. Oyoshi; T. Bando; H. Teraoka; H. Sugiyama K.-I. Shinohara; A. Narita; T. Oyoshi; T. Bando; H. Teraoka; H. Sugiyama Sequence-Specific Gene Silencing in Mammalian Cells by Alkylating Pyrrole-Imidazole Polyamides Sequence-Specific Gene Silencing in Mammalian Cells by Alkylating Pyrrole-Imidazole Polyamides Journal of the American Chemical Society, 126, 16, 5113-5118 , 126, 16, 5113-5118 Journal of the American Chemical Society, 126, 16, 5113-5118 2004 Refereed English Disclose to all
T. Bando; A. Narita; K. Asada; H. Ayame; H. Sugiyama T. Bando; A. Narita; K. Asada; H. Ayame; H. Sugiyama Enantioselective DNA alkylation by a pyrrole-imidazole S-CBI conjugate Enantioselective DNA alkylation by a pyrrole-imidazole S-CBI conjugate Journal of the American Chemical Society, 126, 29, 8948-8955 , 126, 29, 8948-8955 Journal of the American Chemical Society, 126, 29, 8948-8955 2004 Refereed English Disclose to all
T. Oyoshi; W. Kawakami; A. Narita; T. Bando; H. Sugiyama T. Oyoshi; W. Kawakami; A. Narita; T. Bando; H. Sugiyama Inhibition of transcription at a coding sequence by alkylating polyamide Inhibition of transcription at a coding sequence by alkylating polyamide Journal of the American Chemical Society, 125, 16, 4752-4754 , 125, 16, 4752-4754 Journal of the American Chemical Society, 125, 16, 4752-4754 2003 Refereed English Disclose to all
T. Bando; A. Narita; I. Saito; H. Sugiyama T. Bando; A. Narita; I. Saito; H. Sugiyama Highly efficient sequence-specific DNA interstrand cross-linking by pyrrole/imidazole CPI conjugates Highly efficient sequence-specific DNA interstrand cross-linking by pyrrole/imidazole CPI conjugates Journal of the American Chemical Society, 125, 12, 3471-3485 , 125, 12, 3471-3485 Journal of the American Chemical Society, 125, 12, 3471-3485 2003 Refereed English Disclose to all
R. Takahashi; T. Bando; H. Sugiyama R. Takahashi; T. Bando; H. Sugiyama Specific alkylation of human telomere repeats by hairpin pyrrole-imidazole polyamide Specific alkylation of human telomere repeats by hairpin pyrrole-imidazole polyamide Bioorganic and Medicinal Chemistry, 11, 12, 2503-2509 , 11, 12, 2503-2509 Bioorganic and Medicinal Chemistry, 11, 12, 2503-2509 2003 Refereed English Disclose to all
T. Bando; H. Iida; Z.-F. Tao; A. Narita; N. Fukuda; T. Yamori; H. Sugiyama T. Bando; H. Iida; Z.-F. Tao; A. Narita; N. Fukuda; T. Yamori; H. Sugiyama Sequence specificity, reactivity, and antitumor activity of DNA-alkylating pyrrole-imidazole diamides Sequence specificity, reactivity, and antitumor activity of DNA-alkylating pyrrole-imidazole diamides Chemistry and Biology, 10, 8, 751-758 , 10, 8, 751-758 Chemistry and Biology, 10, 8, 751-758 2003 Refereed English Disclose to all
H. Ayame; T. Saito; T. Bando; N. Fukuda; H. Sugiyama H. Ayame; T. Saito; T. Bando; N. Fukuda; H. Sugiyama Fmoc solid-phase synthesis and its application to pyrrole-imidazole polyamides. Fmoc solid-phase synthesis and its application to pyrrole-imidazole polyamides. Nucleic acids research. Supplement (2001), 3, 67-68 , 3, 67-68 Nucleic acids research. Supplement (2001), 3, 67-68 2003 Refereed English Disclose to all
K. Fujimoto; H. Iida; M. Kawakami; T. Bando; Z.-F. Tao; H. Sugiyama K. Fujimoto; H. Iida; M. Kawakami; T. Bando; Z.-F. Tao; H. Sugiyama Sequence-specific protection of plasmid DNA from restriction endonuclease hydrolysis by pyrrole-imidazole-cyclopropapyrroloindole conjugates Sequence-specific protection of plasmid DNA from restriction endonuclease hydrolysis by pyrrole-imidazole-cyclopropapyrroloindole conjugates Nucleic Acids Research, 30, 17, 3748-3753 , 30, 17, 3748-3753 Nucleic Acids Research, 30, 17, 3748-3753 2002 Refereed English Disclose to all
T. Bando; A. Narita; I. Saito; H. Sugiyama T. Bando; A. Narita; I. Saito; H. Sugiyama Molecular design of a pyrrole-imidazole hairpin polyamides for effective DNA alkylation Molecular design of a pyrrole-imidazole hairpin polyamides for effective DNA alkylation Chemistry - A European Journal, 8, 20, 4781-4790 , 8, 20, 4781-4790 Chemistry - A European Journal, 8, 20, 4781-4790 2002 Refereed English Disclose to all
T. Oyoshi; W. Kawakami; T. Bando; A. Narita; H. Sugiyama T. Oyoshi; W. Kawakami; T. Bando; A. Narita; H. Sugiyama Regulation of gene expression by sequence-specific alkylating polyamide. Regulation of gene expression by sequence-specific alkylating polyamide. Nucleic Acids Res Suppl, 2, 259-260 , 2, 259-260 Nucleic Acids Res Suppl, 2, 259-260 2002 Refereed English Disclose to all
A. Narita; T. Bando; H. Sugiyama A. Narita; T. Bando; H. Sugiyama Molecular design of hairpin polyamide possessing sequence-specific alkylation activity. Molecular design of hairpin polyamide possessing sequence-specific alkylation activity. Nucleic Acids Res Suppl, 2, 109-110 , 2, 109-110 Nucleic Acids Res Suppl, 2, 109-110 2002 Refereed English Disclose to all
T. Bando; H. Iida; I. Saito; H. Sugiyama T. Bando; H. Iida; I. Saito; H. Sugiyama Sequence-specific DNA interstrand cross-linking by imidazole-pyrrole CPI conjugate Sequence-specific DNA interstrand cross-linking by imidazole-pyrrole CPI conjugate Journal of the American Chemical Society, 123, 21, 5158-5159 , 123, 21, 5158-5159 Journal of the American Chemical Society, 123, 21, 5158-5159 2001 Refereed English Disclose to all
P.G. Baraldi; G. Balboni; M.G. Pavani; G. Spalluto; M.A. Tabrizi; E. De Clercq; J. Balzarini; T. Bando; H. Sugiyama; R. Romagnoli P.G. Baraldi; G. Balboni; M.G. Pavani; G. Spalluto; M.A. Tabrizi; E. De Clercq; J. Balzarini; T. Bando; H. Sugiyama; R. Romagnoli Design, synthesis, DNA binding, and biological evaluation of water-soluble hybrid molecules containing two pyrazole analogues of the alkylating cyclopropylpyrroloindole (CPI) subunit of the antitumor agent CC-1065 and polypyrrole minor groove binders Design, synthesis, DNA binding, and biological evaluation of water-soluble hybrid molecules containing two pyrazole analogues of the alkylating cyclopropylpyrroloindole (CPI) subunit of the antitumor agent CC-1065 and polypyrrole minor groove binders Journal of Medicinal Chemistry, 44, 16, 2536-2543 , 44, 16, 2536-2543 Journal of Medicinal Chemistry, 44, 16, 2536-2543 2001 Refereed English Disclose to all
K.C. Nicolaou; H.J. Mitchell; N.F. Jain; T. Bando; R. Hughes; N. Winssinger; S. Natarajan; A.E. Koumbis K.C. Nicolaou; H.J. Mitchell; N.F. Jain; T. Bando; R. Hughes; N. Winssinger; S. Natarajan; A.E. Koumbis Total synthesis of vancomycin - Part 4: Attachment of the sugar moieties and completion of the synthesis Total synthesis of vancomycin - Part 4: Attachment of the sugar moieties and completion of the synthesis Chemistry - A European Journal, 5, 9, 2648-2667 , 5, 9, 2648-2667 Chemistry - A European Journal, 5, 9, 2648-2667 1999 Refereed English Disclose to all
K.C. Nicolaou; A.E. Koumbis; M. Takayanagi; S. Natarajan; N.F. Jain; T. Bando; H. Li; R. Hughes K.C. Nicolaou; A.E. Koumbis; M. Takayanagi; S. Natarajan; N.F. Jain; T. Bando; H. Li; R. Hughes Total synthesis of vancomycin - Part 3: Synthesis of the aglycon Total synthesis of vancomycin - Part 3: Synthesis of the aglycon Chemistry - A European Journal, 5, 9, 2622-2647 , 5, 9, 2622-2647 Chemistry - A European Journal, 5, 9, 2622-2647 1999 Refereed English Disclose to all
K.C. Nicolaou; H.J. Mitchell; N.F. Jain; N. Winssinger; R. Hughes; T. Bando K.C. Nicolaou; H.J. Mitchell; N.F. Jain; N. Winssinger; R. Hughes; T. Bando Total synthesis of vancomycin Total synthesis of vancomycin Angewandte Chemie - International Edition, 38, 1/2, 240-244 , 38, 1/2, 240-244 Angewandte Chemie - International Edition, 38, 1/2, 240-244 1999 Refereed English Disclose to all
K. Sato; T. Bando; M. Shindo; K. Shishido K. Sato; T. Bando; M. Shindo; K. Shishido An enantiocontrolled total synthesis of (-)-xanthorrhizol An enantiocontrolled total synthesis of (-)-xanthorrhizol Heterocycles, 50, 1, 11-15 , 50, 1, 11-15 Heterocycles, 50, 1, 11-15 1999 Refereed English Disclose to all
K. Shishido; T. Bando K. Shishido; T. Bando Lipase-mediated asymmetric acetylation of prochiral diols directed towards total syntheses of biologically active molecules Lipase-mediated asymmetric acetylation of prochiral diols directed towards total syntheses of biologically active molecules Journal of Molecular Catalysis - B Enzymatic, 5, 1/4, 183-186 , 5, 1/4, 183-186 Journal of Molecular Catalysis - B Enzymatic, 5, 1/4, 183-186 1998 Refereed English Disclose to all
K.C. Nicolaou; M. Takayanagi; N.F. Jain; S. Natarajan; A.E. Koumbis; T. Bando; J.M. Ramanjulu K.C. Nicolaou; M. Takayanagi; N.F. Jain; S. Natarajan; A.E. Koumbis; T. Bando; J.M. Ramanjulu Total synthesis of vancomycin aglycon - Part 3: Final stages Total synthesis of vancomycin aglycon - Part 3: Final stages Angewandte Chemie - International Edition, 37, 19, 2717-2719 , 37, 19, 2717-2719 Angewandte Chemie - International Edition, 37, 19, 2717-2719 1998 Refereed English Disclose to all
K.C. Nicolaou; N.F. Jain; S. Natarajan; R. Hughes; M.E. Solomon; H. Li; J.M. Ramanjulu; M. Takayanagi; A.E. Koumbis; T. Bando K.C. Nicolaou; N.F. Jain; S. Natarajan; R. Hughes; M.E. Solomon; H. Li; J.M. Ramanjulu; M. Takayanagi; A.E. Koumbis; T. Bando Total synthesis of vancomycin aglycon - Part 2: Synthesis of amino acids 1-3 and construction of the AB-COD-DOE ring skeleton Total synthesis of vancomycin aglycon - Part 2: Synthesis of amino acids 1-3 and construction of the AB-COD-DOE ring skeleton Angewandte Chemie - International Edition, 37, 19, 2714-2716 , 37, 19, 2714-2716 Angewandte Chemie - International Edition, 37, 19, 2714-2716 1998 Refereed English Disclose to all
M. Ozaki; T. Omodani; T. Bando; K. Shishido M. Ozaki; T. Omodani; T. Bando; K. Shishido Enantiocontrolled synthesis of the functionalized cis-decalin Enantiocontrolled synthesis of the functionalized cis-decalin Heterocycles, 47, 1, 81-84 , 47, 1, 81-84 Heterocycles, 47, 1, 81-84 1998 Refereed English Disclose to all
T. Bando; Y. Namba; K. Shishido T. Bando; Y. Namba; K. Shishido Lipase-mediated asymmetric construction of 2-arylpropionic acids: Enantiocontrolled syntheses of S-naproxen and S-ibuprofen Lipase-mediated asymmetric construction of 2-arylpropionic acids: Enantiocontrolled syntheses of S-naproxen and S-ibuprofen Tetrahedron Asymmetry, 8, 13, 2159-2165 , 8, 13, 2159-2165 Tetrahedron Asymmetry, 8, 13, 2159-2165 1997 Refereed English Disclose to all
Y. Fujiwara; T. Yamato; T. Bando; K. Shishido Y. Fujiwara; T. Yamato; T. Bando; K. Shishido A general asymmetric access to the podocarpane diterpenoids A general asymmetric access to the podocarpane diterpenoids Tetrahedron Asymmetry, 8, 16, 2793-2799 , 8, 16, 2793-2799 Tetrahedron Asymmetry, 8, 16, 2793-2799 1997 Refereed English Disclose to all
T. Bando; K. Shishido T. Bando; K. Shishido Chemoenzymatic formal synthesis of (-)-indolmycin Chemoenzymatic formal synthesis of (-)-indolmycin Heterocycles, 46, 1, 111-114 , 46, 1, 111-114 Heterocycles, 46, 1, 111-114 1997 Refereed English Disclose to all
T. Kosaka; T. Bando; K. Shishido T. Kosaka; T. Bando; K. Shishido New asymmetric construction of the benzylic quaternary stereogenic centre: An enantiocontrolled access to (-)-α-cuparenone New asymmetric construction of the benzylic quaternary stereogenic centre: An enantiocontrolled access to (-)-α-cuparenone Chemical Communications, 13, 1167-1168 , 13, 1167-1168 Chemical Communications, 13, 1167-1168 1997 Refereed English Disclose to all
T. Bando; K. Shishido T. Bando; K. Shishido Enantioselective Access to the Mycotoxin, Aflatoxin B<sub>2</sub> Enantioselective Access to the Mycotoxin, Aflatoxin B<sub>2</sub> Synlett, 1997, 6, 665-666 , 1997, 6, 665-666 Synlett, 1997, 6, 665-666 1997 Refereed English Disclose to all
T. Bando; K. Shishido T. Bando; K. Shishido A highly convergent enantioselective total synthesis of marine natural product, furanoterpene A highly convergent enantioselective total synthesis of marine natural product, furanoterpene Chemical Communications, 11, 1357-1358 , 11, 1357-1358 Chemical Communications, 11, 1357-1358 1996 Refereed English Disclose to all

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Author Author(Japanese) Author(English) Title Title(Japanese) Title(English) Bibliography Bibliography(Japanese) Bibliography(English) Publication date Refereed paper Language Publishing type Disclose
M. Minoshima; T. Bando; K. Shinohara; H. Sugiyama M. Minoshima; T. Bando; K. Shinohara; H. Sugiyama Molecular design of sequence specific DNA alkylating agents. Molecular design of sequence specific DNA alkylating agents. Nucleic acids symposium series (2004), 53, 69-70 , 53, 69-70 Nucleic acids symposium series (2004), 53, 69-70 2009 Refereed English Disclose to all
G. Kashiwazaki; T. Bando; H. Sugiyama G. Kashiwazaki; T. Bando; H. Sugiyama Sequence-specific alkylation of DNA by pyrrole-imidazole polyamides through cooperative interaction. Sequence-specific alkylation of DNA by pyrrole-imidazole polyamides through cooperative interaction. Nucleic acids symposium series (2004), 52, 365-366 , 52, 365-366 Nucleic acids symposium series (2004), 52, 365-366 2008 Refereed English Disclose to all
M. Minoshima; J. Chou; S. Lefebvre; T. Bando; K. Shinohara; J.M. Gottesfeld; H. Sugiyama M. Minoshima; J. Chou; S. Lefebvre; T. Bando; K. Shinohara; J.M. Gottesfeld; H. Sugiyama Targeting specific gene by alkylating pyrrole-imidazole polyamides. Targeting specific gene by alkylating pyrrole-imidazole polyamides. Nucleic acids symposium series (2004), 52, 363-364 , 52, 363-364 Nucleic acids symposium series (2004), 52, 363-364 2008 Refereed English Disclose to all
S. Sasaki; M. Minoshima; T. Shimizu; J. Fujimoto; K. Shinohara; T. Bando; H. Sugiyama S. Sasaki; M. Minoshima; T. Shimizu; J. Fujimoto; K. Shinohara; T. Bando; H. Sugiyama The biological impact of sequence-specific DNA alkylation by pyrrole-imidazole polyamides. The biological impact of sequence-specific DNA alkylation by pyrrole-imidazole polyamides. Nucleic acids symposium series (2004), 50, 111-112 , 50, 111-112 Nucleic acids symposium series (2004), 50, 111-112 2006 Refereed English Disclose to all
K. Shinohara; S. Sasaki; T. Bando; H. Sugiyama K. Shinohara; S. Sasaki; T. Bando; H. Sugiyama Sequence-specific gene silencing by alkylating Py-Im polyamide. Sequence-specific gene silencing by alkylating Py-Im polyamide. Nucleic acids symposium series (2004), 49, 75-76 , 49, 75-76 Nucleic acids symposium series (2004), 49, 75-76 2005 Refereed English Disclose to all
T. Watanabe; T. Bando; Y. Xu; H. Sugiyama T. Watanabe; T. Bando; Y. Xu; H. Sugiyama Efficient generation of 2\\'-deoxyuridin-5-yl at 5\\'-(G/C)AA(X)U(X)U-3\\' (X = Br, I) sequences in duplex DNA under UV-irradiation. Efficient generation of 2\\'-deoxyuridin-5-yl at 5\\'-(G/C)AA(X)U(X)U-3\\' (X = Br, I) sequences in duplex DNA under UV-irradiation. Nucleic acids symposium series (2004), 48, 19-20 , 48, 19-20 Nucleic acids symposium series (2004), 48, 19-20 2004 Refereed English Disclose to all
S. Sasaki; A. Narita; T. Bando; H. Sugiyama S. Sasaki; A. Narita; T. Bando; H. Sugiyama Molecular design of alkylating pyrrole-imidazole polyamides with indole linker. Molecular design of alkylating pyrrole-imidazole polyamides with indole linker. Nucleic acids symposium series (2004), 48, 205-206 , 48, 205-206 Nucleic acids symposium series (2004), 48, 205-206 2004 Refereed English Disclose to all
T. Bando; H. Iida; I. Saito; H. Sugiyama T. Bando; H. Iida; I. Saito; H. Sugiyama The synthesis of pyrrole(Py)/imidazole(Im) polyamide CPI conjugates which possess DNA interstrand cross-linking activity. The synthesis of pyrrole(Py)/imidazole(Im) polyamide CPI conjugates which possess DNA interstrand cross-linking activity. Nucleic acids symposium series, 44, 45-46 , 44, 45-46 Nucleic acids symposium series, 44, 45-46 2000 Refereed English Disclose to all
Title language:
Books etc
Author Author(Japanese) Author(English) Title Title(Japanese) Title(English) Publisher Publisher(Japanese) Publisher(English) Publication date Language Type Disclose
杉山 弘 ・ 板東 俊和 杉山 弘 ・ 板東 俊和 基礎ケミカルバイオロジー ISBN978-4-7598-1470-5 基礎ケミカルバイオロジー ISBN978-4-7598-1470-5 化学同人 化学同人 2011/03 Japanese Disclose to all
Title language:
External funds: competitive funds and Grants-in-Aid for Scientific Research (Kakenhi)
Type Position Title(Japanese) Title(English) Period
基盤研究(C) Representative DNAータンパク構造を特異的に制御する機能性ポリアミドの開発 2008-2010
基盤研究B Representative 遺伝子機能を特異的に制御する新規機能性ポリアミドの開発 2012-2015
基盤研究(B) Representative 遺伝子機能を特異的に制御する新規機能性ポリアミドの開発              2012/04/01-2016/03/31
基盤研究(B) Representative 遺伝子機能を特異的に制御する新規機能性ポリアミドの開発              2012-2015
基盤研究(B) Representative 遺伝子機能を特異的に制御する新規機能性ポリアミドの開発 (平成26年度分) 2014/04/01-2015/03/31
基盤研究(B) Representative 遺伝子機能を特異的に制御する新規機能性ポリアミドの開発 (平成27年度分) 2015/04/01-2016/03/31
Teaching subject(s)
Name(Japanese) Name(English) Term Department Period
基礎有機化学A Basic Organic Chemistry A 前期 全学共通科目 2011/04-2012/03
生物化学 IA 前期 理学部 2011/04-2012/03
化学課題研究16 通年 理学部 2011/04-2012/03
生物化学演習 後期 理学部 2011/04-2012/03
化学課題研究16 Special study course II (Chemistry) 16 通年 理学部 2012/04-2013/03
基礎有機化学A Basic Organic Chemistry A 前期 全学共通科目 2012/04-2013/03
生物化学 IA Biochemistry IA 前期 理学部 2012/04-2013/03
生物化学演習 Exercises in Biochemistry 後期 理学部 2012/04-2013/03
生物化学 IA Biochemistry IA 前期 理学部 2013/04-2014/03
生物化学演習 Exercises in Biochemistry 後期 理学部 2013/04-2014/03
化学課題研究16 Special study course II (Chemistry) 16 通年 理学部 2013/04-2014/03
基礎有機化学A Basic Organic Chemistry A 前期 全学共通科目 2013/04-2014/03
生物化学 IA Biochemistry IA 前期 理学部 2014/04-2015/03
生物化学演習 Exercises in Biochemistry 後期 理学部 2014/04-2015/03
化学課題研究16 Special study course II (Chemistry) 16 通年 理学部 2014/04-2015/03
生体分子機能論 Advanced Course in Molecular Biology and Biochemistry 後期 理学研究科 2014/04-2015/03
生物化学ゼミナールIA Seminar on Biochemistry IA 前期 理学研究科 2014/04-2015/03
生物化学ゼミナールIB Seminar on Biochemistry IB 後期 理学研究科 2014/04-2015/03
生物化学ゼミナールIC Seminar on Biochemistry IC 前期 理学研究科 2014/04-2015/03
生物化学ゼミナールID Seminar on Biochemistry ID 後期 理学研究科 2014/04-2015/03
生物化学演習IA Advanced Biochemistry IA 前期 理学研究科 2014/04-2015/03
生物化学演習IB Advanced Biochemistry IB 後期 理学研究科 2014/04-2015/03
生物化学演習IC Advanced Biochemistry IC 前期 理学研究科 2014/04-2015/03
生物化学演習ID Advanced Biochemistry ID 後期 理学研究科 2014/04-2015/03
基礎有機化学A Basic Organic Chemistry A 前期 全学共通科目 2014/04-2015/03
化学課題研究16 Special study course II (Chemistry) 16 通年 理学部 2015/04-2016/03
基礎有機化学I Basic Organic Chemistry I 前期 全学共通科目 2015/04-2016/03
生物化学IV Biochemistry IV 前期 理学部 2015/04-2016/03
生物化学ゼミナールIA Seminar on Biochemistry IA 前期 理学研究科 2015/04-2016/03
生物化学ゼミナールIB Seminar on Biochemistry IB 後期 理学研究科 2015/04-2016/03
生物化学ゼミナールIC Seminar on Biochemistry IC 前期 理学研究科 2015/04-2016/03
生物化学ゼミナールID Seminar on Biochemistry ID 後期 理学研究科 2015/04-2016/03
生物化学演習IA Advanced Biochemistry IA 前期 理学研究科 2015/04-2016/03
生物化学演習IB Advanced Biochemistry IB 後期 理学研究科 2015/04-2016/03
生物化学演習IC Advanced Biochemistry IC 前期 理学研究科 2015/04-2016/03
生物化学演習ID Advanced Biochemistry ID 後期 理学研究科 2015/04-2016/03
生物化学演習 Exercises in Biochemistry 後期 理学部 2015/04-2016/03
化学課題研究16 Special study course II (Chemistry) 16 通年 理学部 2016/04-2017/03
基礎化学実験 Fundamental Chemical Experiments 後期 全学共通科目 2016/04-2017/03
生体分子機能論 Advanced Course in Molecular Biology and Biochemistry 後期 理学研究科 2016/04-2017/03
生物化学IV Biochemistry IV 前期 理学部 2016/04-2017/03
生物化学ゼミナールIA Seminar on Biochemistry IA 前期 理学研究科 2016/04-2017/03
生物化学ゼミナールIB Seminar on Biochemistry IB 後期 理学研究科 2016/04-2017/03
生物化学ゼミナールIC Seminar on Biochemistry IC 前期 理学研究科 2016/04-2017/03
生物化学ゼミナールID Seminar on Biochemistry ID 後期 理学研究科 2016/04-2017/03
生物化学演習IA Advanced Biochemistry IA 前期 理学研究科 2016/04-2017/03
生物化学演習IB Advanced Biochemistry IB 後期 理学研究科 2016/04-2017/03
生物化学演習IC Advanced Biochemistry IC 前期 理学研究科 2016/04-2017/03
生物化学演習ID Advanced Biochemistry ID 後期 理学研究科 2016/04-2017/03
生物化学演習 Exercises in Biochemistry 後期 理学部 2016/04-2017/03
化学課題研究16 Special study course II (Chemistry) 16 通年 理学部 2017/04-2018/03
生物化学IV Biochemistry IV 前期 理学部 2017/04-2018/03
生物化学ゼミナールIA Seminar on Biochemistry IA 前期 理学研究科 2017/04-2018/03
生物化学ゼミナールIB Seminar on Biochemistry IB 後期 理学研究科 2017/04-2018/03
生物化学ゼミナールIC Seminar on Biochemistry IC 前期 理学研究科 2017/04-2018/03
生物化学ゼミナールID Seminar on Biochemistry ID 後期 理学研究科 2017/04-2018/03
生物化学演習IA Advanced Biochemistry IA 前期 理学研究科 2017/04-2018/03
生物化学演習IB Advanced Biochemistry IB 後期 理学研究科 2017/04-2018/03
生物化学演習IC Advanced Biochemistry IC 前期 理学研究科 2017/04-2018/03
生物化学演習ID Advanced Biochemistry ID 後期 理学研究科 2017/04-2018/03
生物化学演習 Exercises in Biochemistry 後期 理学部 2017/04-2018/03
化学課題研究16 Special study course II (Chemistry) 16 通年 理学部 2018/04-2019/03
生体分子機能論 Advanced Course in Molecular Biology and Biochemistry 後期 理学研究科 2018/04-2019/03
生物化学IV Biochemistry IV 前期 理学部 2018/04-2019/03
生物化学ゼミナールIA Seminar on Biochemistry IA 前期 理学研究科 2018/04-2019/03
生物化学ゼミナールIB Seminar on Biochemistry IB 後期 理学研究科 2018/04-2019/03
生物化学ゼミナールIC Seminar on Biochemistry IC 前期 理学研究科 2018/04-2019/03
生物化学ゼミナールID Seminar on Biochemistry ID 後期 理学研究科 2018/04-2019/03
生物化学演習IA Advanced Biochemistry IA 前期 理学研究科 2018/04-2019/03
生物化学演習IB Advanced Biochemistry IB 後期 理学研究科 2018/04-2019/03
生物化学演習IC Advanced Biochemistry IC 前期 理学研究科 2018/04-2019/03
生物化学演習ID Advanced Biochemistry ID 後期 理学研究科 2018/04-2019/03
生物化学演習 Exercises in Biochemistry 後期 理学部 2018/04-2019/03

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School management (title, position)
Title Period
オープンキャンパス委員会 委員長代行 2017/01/01-2017/12/31
Faculty management (title, position)
Title Period
理学部・教育委員会委員 2014/04/01-2015/03/31
理学部・教育委員会委員 2015/04/01-2016/03/31
理学研究科国際・社会交流委員会委員 2015/04/01-2016/03/31
理学研究科国際・社会交流委員会 OpenCampus委員会委員 2015/04/01-2016/03/31
理学部・教育委員会委員 2016/04/01-2017/03/31
理学研究科国際・社会交流委員会委員 2016/04/01-2017/03/31
理学研究科国際・社会交流委員会 OpenCampus委員会委員 2016/04/01-2017/03/31
理学部・教育委員会委員 2017/04/01-2018/03/31
理学研究科国際・社会交流委員会委員 2017/04/01-2018/03/31
理学研究科国際・社会交流委員会 OpenCampus委員会委員長 2017/04/01-2018/03/31