1. Mechanism of cell competition, 2. Genetic basis of tissue growth regulation, 3. Molecular basis of tumor progression and metastasis
Overview of the research
Our research focuses on the molecular basis of cell-cell communication that governs tissue growth, homeostasis, and cancer. We take advantage of the powerful genetics of Drosophila.
Research Areas
Life sciences, Developmental biology
Life sciences, Cell biology
Papers
In vivo evidence for homeostatic regulation of ribosomal protein levels in Drosophila.
Daiki Kitamura; Kiichiro Taniguchi; Mai Nakamura; Tatsushi Igaki
Cell structure and function, 16 Feb. 2024
Editorial note: flying high in Japan
Ryusuke Niwa; Makoto Sato; Tatsushi Igaki
Fly, 06 Mar. 2023
Cell-cell interactions that drive tumorigenesis in Drosophila
Masato Enomoto; Tatsushi Igaki
Fly, 22 Nov. 2022
Sas-Ptp10D shapes germ-line stem cell niche by facilitating JNK-mediated apoptosis.
Kiichiro Taniguchi; Tatsushi Igaki
PLoS genetics, 27 Mar. 2023
JNK and Yorkie drive tumor malignancy by inducing L-amino acid transporter 1 in Drosophila.
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH, Mar. 2004, Peer-reviewed
Reaper-mediated inhibition of DIAP1-induced DTRAF1 degradation results in activation of JNK in Drosophila
E Kuranaga; H Kanuka; T Igaki; K Sawamoto; H Ichijo; H Okano; M Miura
NATURE CELL BIOLOGY, Sep. 2002, Peer-reviewed
Wengen, a member of the Drosophila tumor necrosis factor receptor superfamily, is required for Eiger signaling
H Kanda; T Igaki; H Kanuka; T Yagi; M Miura
JOURNAL OF BIOLOGICAL CHEMISTRY, Aug. 2002, Peer-reviewed
Down-regulation of DIAP1 triggers a novel Drosophila cell death pathway mediated by dark and DRONC
T Igaki; Y Yamamoto-Goto; N Tokushige; H Kanda; M Miura
JOURNAL OF BIOLOGICAL CHEMISTRY, Jun. 2002, Peer-reviewed
Eiger, a TNF superfamily ligand that triggers the Drosophila JNK pathway
T Igaki; H Kanda; Y Yamamoto-Goto; H Kanuka; E Kuranaga; T Aigaki; M Miura
EMBO JOURNAL, Jun. 2002, Peer-reviewed
Molecular mechanism of 5-fluoro-2'-deoxyuridine-induced dNTP imbalance cell death: Purification of an endonuclease involved in DNA double strand breaks during dNTP imbalance death
H Hwang; M Ohtani; T Nakazawa; T Igaki; O Masui; S Kankawa; C Nakayama; S Yoshida; A YoshiokaHiramoto; Y Wataya
NUCLEOSIDES & NUCLEOTIDES, 1995, Peer-reviewed
Misc.
細胞間コミュニケーションによるがん進展制御
榎本 将人; 本田 直樹; 武本 花奈美; 竹本 大策; 井垣 達吏
生命科学系学会合同年次大会, Dec. 2017
がん遺伝子活性の不均一性による腫瘍悪性化
榎本 将人; 竹本 大策; 井垣 達吏
日本細胞生物学会大会講演要旨集, May 2016
がん遺伝子活性の不均一性による腫瘍悪性化の分子基盤
榎本 将人; 竹本 大策; 井垣 達吏
日本細胞生物学会大会講演要旨集, Jun. 2015
細胞競合を駆動する細胞非自律的な細胞死誘導機構の解析
中村 麻衣; 近藤 周; 齋藤 都暁; 井垣 達吏
日本細胞生物学会大会講演要旨集, Jun. 2020
細胞競合の勝敗を規定する組織環境条件の遺伝学および数理学的解析
片山宰; 西川星也; 大澤志津江; 高松敦子; 井垣達吏
日本生化学会大会(Web), 2017
Lotka-Volterra competition modelに基づく細胞競合モデル
西川星也; 高松敦子; 大澤志津江; 井垣達吏
日本数理生物学会大会講演要旨集, 2013
The role mechanical force in epithelial maintenance and cell competition
山本 真寿; 井垣 達吏
医学のあゆみ, 04 Jun. 2016
Role of Hippo signaling in cell-cell cooperation and competition
榎本 将人; 井垣 達吏
医学のあゆみ, 01 Nov. 2014
システミックな細胞競合制御によるがん発生メカニズム
掛村 文吾; 井垣 達吏
Journal of Japanese Biochemical Society, Jun. 2021
ショウジョウバエからみえてきた細胞老化と個体老化の分子リンク
井藤喬夫; 井垣達吏
Dec. 2020
ショウジョウバエにおける細胞老化と SASP
芥真弓; 井垣達吏
Sep. 2020
細胞競合による生体制御とがん(はじめに)
井垣達吏
医学のあゆみ第1土曜特集, Aug. 2020, Lead author, Last author, Corresponding author
Molecular mechanism of cell competition identified in Drosophila
永田理奈; 井垣達吏
医学のあゆみ, Aug. 2020, Last author, Corresponding author
Epithelial cell extrusion by mechanical force
永田理奈; 井垣達吏
実験医学, Apr. 2020, Last author, Corresponding author
細胞競合によるがん制御
榎本将人; 井垣達吏
三浦正幸・清水重臣編 「細胞死 -Cell Death- 」, Aug. 2019, Last author, Corresponding author
ショウジョウバエにおける細胞老化とSASPの制御機構
吉田大祐; 井藤喬夫; 井垣達吏
アンチエイジング医学 日本抗加齢医学会 「老化と炎症」, Jun. 2019, Last author, Corresponding author
総論 細胞の協調と競合によるがん微小環境制御
井垣達吏
月刊 細胞 「特集 がん微小環境」, May 2018, Lead author, Last author, Corresponding author
The ligand-receptor Sas-PTP10D drives tumor-suppressive cell competition
Src controls tumorigenesis through JNK-dependent tissue growth regulation in Drosophil
M.Enomoto; T. Igaki
The EMBO meeting 2012, 25 Sep. 2012
Dissecting cell competition through “non-cell autonomous” genetic screen in Drosophila
IGAKI TATSUSHI
Cold-blooded Cancer, 02 Sep. 2012, Invited
細胞競合による上皮の恒常性維持とがん制御
井垣達吏
第8回宮崎サイエンスキャンプ, 17 Feb. 2012, Invited
Dissecting tumor suppression and metastasis by Drosophila genetics
IGAKI TATSUSHI
The 21st Hot Spring Harbor Symposium jointly with 8th Global COE International Symposium “Cell Migration in Biology and Medicine”, 22 Jan. 2012, Invited
Src, a novel super-competitor in Drosophila
榎本将人; 井垣達吏
第34回日本分子生物学会年会, 13 Dec. 2011
細胞非自律的な腫瘍悪性化機構の遺伝学的解析
佐藤好隆; 大澤志津江; 中村麻衣; 別宮綾; 井垣達吏
第70回日本癌学会学術総会, 03 Oct. 2011
Src activation triggers non-cell autonomous apoptosis through endocytic activation of TNF-JNK signaling
M. Enomot; T. Igaki
Non-autonomous tumor progression driven by Ras activation and mitochondrial dysfunction, 29 Sep. 2011
Non-autonomous tumor progression driven by Ras activation and mitochondrial dysfunction
S. Ohsawa; K. Sugimura; K. Takino; T. Xu; A. Miyawaki; T. Igaki
Non-autonomous tumor progression driven by Ras activation and mitochondrial dysfunction, 29 Sep. 2011
がん遺伝子Srcが引き起こす細胞競合の分子機構
榎本将人; 井垣達吏
第23回高遠シンポジウム, 25 Aug. 2011
細胞間コミュニケーションを介した腫瘍悪性化の遺伝学的解析
大澤志津江; 佐藤好隆; 榎本将人; 中村麻衣; 別宮綾; 井垣達吏
第23回高遠シンポジウム, 25 Aug. 2011
細胞競合による上皮の異常細胞排除機構
井垣達吏
第23回高遠シンポジウム, 25 Aug. 2011, Invited
細胞間コミュニケーションを介した腫瘍悪性化機構の遺伝学的解析
大澤志津江; 佐藤好隆; 中村麻衣; 別宮綾; 井垣達吏
第20回日本Cell Death学会学術集会, 29 Jul. 2011
がん遺伝子㻿rcによる細胞間コミュニケーションを介した細 胞死制御
井垣達吏; 榎本将人
第20回 日本Cell Death学会学術集会, 29 Jul. 2011
Elimination of oncogenic neighbors by JNK-mediated engulfment in Drosophila
S. Ohsawa; K. Sugimura; K. Takino; Xu. T; A. Miyawaki; T. Igaki
第63回日本細胞生物学会大会, 27 Jun. 2011
Elimination of oncogenic neighbors by JNK-mediated engulfment in Drosophila
IGAKI TATSUSHI
1st Asia-Pacific Drosophila Research, 22 May 2011
Elimination of oncogenic neighbors by TNF-JNK-mediated engulfment in Drosophila
S. Ohsawa; K. Sugimura; K. Takino; T. Xu; A. Miyawaki; T. Igaki
13th International TNF Conference (TNF2011), 15 May 2011
Epithelial intrinsic tumor suppression by Eiger/TNF signaling in Drosophila
IGAKI TATSUSHI
13th International TNF Conference (TNF2011), 15 May 2011, Invited
Hyperinsulinemia promotes tumorigenesi by abrogating cell competition
Yuya Sanaki; Daisuke Kizawa; Tatsushi Igaki
16th International Student seminar
Epithelial cell-turnover in Minute animals: a possible role of cell competition in morphogenetic robustness