奥野 恭史

Last Update: 2018/06/26 12:31:15

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Name(Kanji/Kana/Abecedarium Latinum)
奥野 恭史/オクノ ヤスシ/Okuno, Yasushi
Primary department(Org1/Job title)
Graduate Schools Medicine/Professor
Faculty
Org1 Job title
医学部
Contact address
Type Address(Japanese) Address(English)
Office 606-8507 京都市左京区聖護院川原町54 54 Kawahara-cho, Syogoin, Sakyo-ku, Kyoto 606-8507 Japan
Phone
Type Number
Office 075-751-4881
E-mail address
E-mail address
clinfojimu @ hs.med.kyoto-u.ac.jp
Academic degree
Field(Japanese) Field(English) University(Japanese) University(English) Method
修士(薬学) 京都大学
博士(薬学) 京都大学
Graduate school
University(Japanese) University(English) Faculty(Japanese) Faculty(English) Major(Japanese) Major(English) Degree
京都大学 大学院薬学研究科修士課程薬品作用制御システム専攻 修了
University
University(Japanese) University(English) Faculty(Japanese) Faculty(English) Major(s)(Japanese) Major(s)(English) Degree
京都大学 薬学部 卒業
Work Experience
Period Organization(Japanese) Organization(English) Job title(Japanese) Job title(English)
2008/10/01-2013/09/31 京都大学大学院 薬学研究科 寄附講座システム創薬科学 教授
2013/10/01-2014/03/31 京都大学大学院薬学研究科 統合薬学教育開発センター 薬学オープンイノベーション部門 教授
Personal website address
URL
http://clinfo.med.kyoto-u.ac.jp/
Research Topics
(Japanese)
ゲノム医療、個別化医療、革新的創薬等の最先端医療のための研究開発
Overview of your research
(Japanese)
創薬・医療分野において、これまでの分子標的アプローチでは対応できなかった多因子性疾患に対処するために、病態や薬効を生体システム全体の動きとして捉えることの重要性が高まっている。本研究では、薬物による多重標的薬理作用のシステム的解析やそのドラッグデザインを行い、生体のシステム的制御を志向した創薬計算手法の開発を行う。これにより、より効果的かつ安全性の高い医薬品の創製が加速化されることが期待される。
Published Papers
Author Author(Japanese) Author(English) Title Title(Japanese) Title(English) Bibliography Bibliography(Japanese) Bibliography(English) Publication date Refereed paper Language Publishing type Disclose
T. Inoue; H. Adachi; S. Murakami; K. Takano; H. Matsumura; Y. Mori; Y. Fukunishi; H. Nakamura; T. Kinoshita; I. Nakanishi; Y. Okuno; S. Minakata; S. Shimojo; T. Sakata T. Inoue; H. Adachi; S. Murakami; K. Takano; H. Matsumura; Y. Mori; Y. Fukunishi; H. Nakamura; T. Kinoshita; I. Nakanishi; Y. Okuno; S. Minakata; S. Shimojo; T. Sakata New progressing crystallization technology of membrane protein and introduction of pharamaceutical innovation value chain New progressing crystallization technology of membrane protein and introduction of pharamaceutical innovation value chain Yakugaku Zasshi, 128, 4, 497-505 Yakugaku Zasshi, 128, 4, 497-505 , 128, 4, 497-505 2008 Refereed Japanese Disclose to all
Y. Okuno Y. Okuno In silico drug discovery based on the integration of bioinformatics and chemoinformatics In silico drug discovery based on the integration of bioinformatics and chemoinformatics Yakugaku Zasshi, 128, 11, 1645-1651 Yakugaku Zasshi, 128, 11, 1645-1651 , 128, 11, 1645-1651 2008 Refereed Japanese Disclose to all
S. Nakazawa; M. Sakanaka; K. Furuta; M. Natsuhara; H. Takano; S. Tsuchiya; Y. Okuno; H. Ohtsu; M. Nishibori; R.L. Thurmond; N. Hirasawa; K. Nakayama; A. Ichikawa; Y. Sugimoto; S. Tanaka S. Nakazawa; M. Sakanaka; K. Furuta; M. Natsuhara; H. Takano; S. Tsuchiya; Y. Okuno; H. Ohtsu; M. Nishibori; R.L. Thurmond; N. Hirasawa; K. Nakayama; A. Ichikawa; Y. Sugimoto; S. Tanaka Histamine synthesis is required for granule maturation in murine mast cells Histamine synthesis is required for granule maturation in murine mast cells European Journal of Immunology, 44, 1, 204-214 , 44, 1, 204-214 European Journal of Immunology, 44, 1, 204-214 2014 Refereed English Disclose to all
Y. Yamaguchi; T. Suzuki; Y. Mizoro; H. Kori; K. Okada; Y. Chen; J.-M. Fustin; F. Yamazaki; N. Mizuguchi; J. Zhang; X. Dong; G. Tsujimoto; Y. Okuno; M. Doi; H. Okamura Y. Yamaguchi; T. Suzuki; Y. Mizoro; H. Kori; K. Okada; Y. Chen; J.-M. Fustin; F. Yamazaki; N. Mizuguchi; J. Zhang; X. Dong; G. Tsujimoto; Y. Okuno; M. Doi; H. Okamura Mice genetically deficient in vasopressin V1a and V1b receptors are resistant to jet lag Mice genetically deficient in vasopressin V1a and V1b receptors are resistant to jet lag Science, 342, 6154, 85-90 , 342, 6154, 85-90 Science, 342, 6154, 85-90 2013/10/04 Refereed English Disclose to all
E. Segi-Nishida; M. Sukeno; Y. Imoto; T. Kira; M. Sakaida; S. Tsuchiya; Y. Sugimoto; Y. Okuno E. Segi-Nishida; M. Sukeno; Y. Imoto; T. Kira; M. Sakaida; S. Tsuchiya; Y. Sugimoto; Y. Okuno Electroconvulsive seizures activate anorexigenic signals in the ventromedial nuclei of the hypothalamus Electroconvulsive seizures activate anorexigenic signals in the ventromedial nuclei of the hypothalamus Neuropharmacology, 71, 164-173 , 71, 164-173 Neuropharmacology, 71, 164-173 2013/08 Refereed English Disclose to all
K. Yoshimura; T. Sakaeda; K. Kadoyama; Y. Sugino; O. Ogawa; Y. Okuno K. Yoshimura; T. Sakaeda; K. Kadoyama; Y. Sugino; O. Ogawa; Y. Okuno A survey of the FAERS database concerning the adverse event profiles of α1-adrenoreceptor blockers for lower urinary tract symptoms A survey of the FAERS database concerning the adverse event profiles of α1-adrenoreceptor blockers for lower urinary tract symptoms International Journal of Medical Sciences, 10, 7, 864-869 , 10, 7, 864-869 International Journal of Medical Sciences, 10, 7, 864-869 2013 Refereed English Disclose to all
A. Shiraishi; S. Niijima; J.B. Brown; M. Nakatsui; Y. Okuno A. Shiraishi; S. Niijima; J.B. Brown; M. Nakatsui; Y. Okuno Chemical genomics approach for GPCR-ligand interaction prediction and extraction of ligand binding determinants Chemical genomics approach for GPCR-ligand interaction prediction and extraction of ligand binding determinants Journal of Chemical Information and Modeling, 53, 6, 1253-1262 , 53, 6, 1253-1262 Journal of Chemical Information and Modeling, 53, 6, 1253-1262 2013 Refereed English Disclose to all
M. Sakaida; M. Sukeno; Y. Imoto; S. Tsuchiya; Y. Sugimoto; Y. Okuno; E. Segi-Nishida M. Sakaida; M. Sukeno; Y. Imoto; S. Tsuchiya; Y. Sugimoto; Y. Okuno; E. Segi-Nishida Electroconvulsive seizure-induced changes in gene expression in the mouse hypothalamic paraventricular nucleus Electroconvulsive seizure-induced changes in gene expression in the mouse hypothalamic paraventricular nucleus Journal of Psychopharmacology, 27, 11, 1058-1069 , 27, 11, 1058-1069 Journal of Psychopharmacology, 27, 11, 1058-1069 2013 Refereed English Disclose to all
S.Z. Fazekas; H. Ito; Y. Okuno; S. Seki; K. Taneishi S.Z. Fazekas; H. Ito; Y. Okuno; S. Seki; K. Taneishi On computational complexity of graph inference from counting On computational complexity of graph inference from counting Natural Computing, 12, 4, 589-603 , 12, 4, 589-603 Natural Computing, 12, 4, 589-603 2013 Refereed English Disclose to all
D. Kobayashi; S. Hosaka; E. Inoue; K. Ohshima; N. Kutsuma; S. Oshima; Y. Okuno D. Kobayashi; S. Hosaka; E. Inoue; K. Ohshima; N. Kutsuma; S. Oshima; Y. Okuno Quantitative evaluation of initial symptoms as predictors to detect adverse drug reactions using bayes\\' theory: Expansion and evaluation of drug-adverse drug reaction-initial symptom combinations using adverse event reporting system database Quantitative evaluation of initial symptoms as predictors to detect adverse drug reactions using bayes\\' theory: Expansion and evaluation of drug-adverse drug reaction-initial symptom combinations using adverse event reporting system database Biological and Pharmaceutical Bulletin, 36, 12, 1891-1901 , 36, 12, 1891-1901 Biological and Pharmaceutical Bulletin, 36, 12, 1891-1901 2013 Refereed English Disclose to all
J.B. Brown; S. Niijima; Y. Okuno J.B. Brown; S. Niijima; Y. Okuno Compound-protein interaction prediction within chemogenomics: Theoretical concepts, practical usage, and future directions Compound-protein interaction prediction within chemogenomics: Theoretical concepts, practical usage, and future directions Molecular Informatics, 32, 11-12, 906-921 , 32, 11-12, 906-921 Molecular Informatics, 32, 11-12, 906-921 2013 Refereed English Disclose to all
T. Sakaeda; A. Tamon; K. Kadoyama; Y. Okuno T. Sakaeda; A. Tamon; K. Kadoyama; Y. Okuno Data mining of the public version of the FDA adverse event reporting system Data mining of the public version of the FDA adverse event reporting system International Journal of Medical Sciences, 10, 7, 796-803 , 10, 7, 796-803 International Journal of Medical Sciences, 10, 7, 796-803 2013 Refereed English Disclose to all
K. Kadoyama; T. Sakaeda; A. Tamon; Y. Okuno K. Kadoyama; T. Sakaeda; A. Tamon; Y. Okuno Adverse event profile of tigecycline: Data mining of the public version of the U.S. Food and Drug Administration adverse event reporting system Adverse event profile of tigecycline: Data mining of the public version of the U.S. Food and Drug Administration adverse event reporting system Biological and Pharmaceutical Bulletin, 35, 6, 967-970 , 35, 6, 967-970 Biological and Pharmaceutical Bulletin, 35, 6, 967-970 2012/06 Refereed English Disclose to all
S. Niijima; A. Shiraishi; Y. Okuno S. Niijima; A. Shiraishi; Y. Okuno Dissecting kinase profiling data to predict activity and understand cross-reactivity of kinase inhibitors Dissecting kinase profiling data to predict activity and understand cross-reactivity of kinase inhibitors Journal of Chemical Information and Modeling, 52, 4, 901-912 , 52, 4, 901-912 Journal of Chemical Information and Modeling, 52, 4, 901-912 2012/04 Refereed English Disclose to all
Y. Katoh-Fukui; K. Miyabayashi; T. Komatsu; A. Owaki; T. Baba; Y. Shima; T. Kidokoro; Y. Kanai; A. Schedl; D. Wilhelm; P. Koopman; Y. Okuno; K.-I. Morohashi Y. Katoh-Fukui; K. Miyabayashi; T. Komatsu; A. Owaki; T. Baba; Y. Shima; T. Kidokoro; Y. Kanai; A. Schedl; D. Wilhelm; P. Koopman; Y. Okuno; K.-I. Morohashi Cbx2, a polycomb group gene, is required for Sry gene expression in mice Cbx2, a polycomb group gene, is required for Sry gene expression in mice Endocrinology, 153, 2, 913-924 , 153, 2, 913-924 Endocrinology, 153, 2, 913-924 2012 Refereed English Disclose to all
Y. Minowa; C. Kondo; T. Uehara; Y. Morikawa; Y. Okuno; N. Nakatsu; A. Ono; T. Maruyama; I. Kato; J. Yamate; H. Yamada; Y. Ohno; T. Urushidani Y. Minowa; C. Kondo; T. Uehara; Y. Morikawa; Y. Okuno; N. Nakatsu; A. Ono; T. Maruyama; I. Kato; J. Yamate; H. Yamada; Y. Ohno; T. Urushidani Toxicogenomic multigene biomarker for predicting the future onset of proximal tubular injury in rats Toxicogenomic multigene biomarker for predicting the future onset of proximal tubular injury in rats Toxicology, 297, 1-3, 47-56 , 297, 1-3, 47-56 Toxicology, 297, 1-3, 47-56 2012 Refereed English Disclose to all
S. Seki; Y. Okuno S. Seki; Y. Okuno On the behavior of tile assembly system at high temperatures On the behavior of tile assembly system at high temperatures Lecture Notes in Computer Science (including subseries Lecture Notes in Artificial Intelligence and Lecture Notes in Bioinformatics), 7318, 549-559 , 7318, 549-559 Lecture Notes in Computer Science (including subseries Lecture Notes in Artificial Intelligence and Lecture Notes in Bioinformatics), 7318, 549-559 2012 Refereed English Disclose to all
J.B. Brown; Y. Okuno J.B. Brown; Y. Okuno Systems biology and systems chemistry: New directions for drug discovery Systems biology and systems chemistry: New directions for drug discovery Chemistry and Biology, 19, 1, 23-28 , 19, 1, 23-28 Chemistry and Biology, 19, 1, 23-28 2012 Refereed English Disclose to all
T. Tamura; T. Sakaeda; K. Kadoyama; Y. Okuno T. Tamura; T. Sakaeda; K. Kadoyama; Y. Okuno Omeprazole- and esomeprazole-associated hypomagnesaemia:Data mining of the public version of the fda adverse event reporting system Omeprazole- and esomeprazole-associated hypomagnesaemia:Data mining of the public version of the fda adverse event reporting system International Journal of Medical Sciences, 9, 5, 322-326 , 9, 5, 322-326 International Journal of Medical Sciences, 9, 5, 322-326 2012 Refereed English Disclose to all
T. Tamura; T. Sakaeda; K. Kadoyama; Y. Okuno T. Tamura; T. Sakaeda; K. Kadoyama; Y. Okuno Aspirin- and clopidogrel-associated bleeding complications: Data mining of the public version of the FDA adverse event reporting system, AERS Aspirin- and clopidogrel-associated bleeding complications: Data mining of the public version of the FDA adverse event reporting system, AERS International Journal of Medical Sciences, 9, 6, 441-446 , 9, 6, 441-446 International Journal of Medical Sciences, 9, 6, 441-446 2012 Refereed English Disclose to all
K. Kadoyama; I. Miki; T. Tamura; J.B. Brown; T. Sakaeda; Y. Okuno K. Kadoyama; I. Miki; T. Tamura; J.B. Brown; T. Sakaeda; Y. Okuno Adverse event profiles of 5-fluorouracil and Capecitabine: Data mining of the public version of the FDA adverse event reporting system, AERS, and reproducibility of clinical observations Adverse event profiles of 5-fluorouracil and Capecitabine: Data mining of the public version of the FDA adverse event reporting system, AERS, and reproducibility of clinical observations International Journal of Medical Sciences, 9, 1, 33-39 , 9, 1, 33-39 International Journal of Medical Sciences, 9, 1, 33-39 2012 Refereed English Disclose to all
T. Sakaeda; K. Kadoyama; Y. Okuno T. Sakaeda; K. Kadoyama; Y. Okuno Statin-associated muscular and renal adverse events: Data mining of the public version of the FDA adverse event reporting system Statin-associated muscular and renal adverse events: Data mining of the public version of the FDA adverse event reporting system PLoS ONE, 6, 12 , 6, 12 PLoS ONE, 6, 12 2011/12/20 Refereed English Disclose to all
S. Niijima; H. Yabuuchi; Y. Okuno S. Niijima; H. Yabuuchi; Y. Okuno Cross-target view to feature selection: Identification of molecular interaction features in ligand-target space Cross-target view to feature selection: Identification of molecular interaction features in ligand-target space Journal of Chemical Information and Modeling, 51, 1, 15-24 , 51, 1, 15-24 Journal of Chemical Information and Modeling, 51, 1, 15-24 2011/01 Refereed English Disclose to all
H. Yabuuchi; S. Niijima; H. Takematsu; T. Ida; T. Hirokawa; T. Hara; T. Ogawa; Y. Minowa; G. Tsujimoto; Y. Okuno H. Yabuuchi; S. Niijima; H. Takematsu; T. Ida; T. Hirokawa; T. Hara; T. Ogawa; Y. Minowa; G. Tsujimoto; Y. Okuno Analysis of multiple compound-protein interactions reveals novel bioactive molecules Analysis of multiple compound-protein interactions reveals novel bioactive molecules Molecular Systems Biology, 7 , 7 Molecular Systems Biology, 7 2011 Refereed English Disclose to all
M.-A. Shibata; M. Iinuma; J. Morimoto; H. Kurose; K. Akamatsu; Y. Okuno; Y. Akao; Y. Otsuki M.-A. Shibata; M. Iinuma; J. Morimoto; H. Kurose; K. Akamatsu; Y. Okuno; Y. Akao; Y. Otsuki α-Mangostin extracted from the pericarp of the mangosteen (Garcinia mangostana Linn) reduces tumor growth and lymph node metastasis in an immunocompetent xenograft model of metastatic mammary cancer carrying a p53 mutation α-Mangostin extracted from the pericarp of the mangosteen (Garcinia mangostana Linn) reduces tumor growth and lymph node metastasis in an immunocompetent xenograft model of metastatic mammary cancer carrying a p53 mutation BMC Medicine, 9 , 9 BMC Medicine, 9 2011 Refereed English Disclose to all
H. Takematsu; H. Yamamoto; Y. Naito-Matsui; R. Fujinawa; K. Tanaka; Y. Okuno; Y. Tanaka; M. Kyogashima; R. Kannagi; Y. Kozutsumi H. Takematsu; H. Yamamoto; Y. Naito-Matsui; R. Fujinawa; K. Tanaka; Y. Okuno; Y. Tanaka; M. Kyogashima; R. Kannagi; Y. Kozutsumi Quantitative transcriptomic profiling of branching in a glycosphingolipid biosynthetic pathway Quantitative transcriptomic profiling of branching in a glycosphingolipid biosynthetic pathway Journal of Biological Chemistry, 286, 31, 27214-27224 , 286, 31, 27214-27224 Journal of Biological Chemistry, 286, 31, 27214-27224 2011 Refereed English Disclose to all
K. Kadoyama; A. Kuwahara; M. Yamamori; J.B. Brown; T. Sakaeda; Y. Okuno K. Kadoyama; A. Kuwahara; M. Yamamori; J.B. Brown; T. Sakaeda; Y. Okuno Hypersensitivity reactions to anticancer agents: Data mining of the public version of the FDA adverse event reporting system, AERS Hypersensitivity reactions to anticancer agents: Data mining of the public version of the FDA adverse event reporting system, AERS Journal of Experimental and Clinical Cancer Research, 30 , 30 Journal of Experimental and Clinical Cancer Research, 30 2011 Refereed English Disclose to all
S. Tamba; R. Yodoi; K. Morimoto; T. Inazumi; M. Sukeno; E. Segi-Nishida; Y. Okuno; G. Tsujimoto; S. Narumiya; Y. Sugimoto S. Tamba; R. Yodoi; K. Morimoto; T. Inazumi; M. Sukeno; E. Segi-Nishida; Y. Okuno; G. Tsujimoto; S. Narumiya; Y. Sugimoto Expression profiling of cumulus cells reveals functional changes during ovulation and central roles of prostaglandin EP2 receptor in cAMP signaling Expression profiling of cumulus cells reveals functional changes during ovulation and central roles of prostaglandin EP2 receptor in cAMP signaling Biochimie, 92, 6, 665-675 , 92, 6, 665-675 Biochimie, 92, 6, 665-675 2010/06 Refereed English Disclose to all
M. Doi; Y. Takahashi; R. Komatsu; F. Yamazaki; H. Yamada; S. Haraguchi; N. Emoto; Y. Okuno; G. Tsujimoto; A. Kanematsu; O. Ogawa; T. Todo; K. Tsutsui; G.T.J. Van Der Horst; H. Okamura M. Doi; Y. Takahashi; R. Komatsu; F. Yamazaki; H. Yamada; S. Haraguchi; N. Emoto; Y. Okuno; G. Tsujimoto; A. Kanematsu; O. Ogawa; T. Todo; K. Tsutsui; G.T.J. Van Der Horst; H. Okamura Salt-sensitive hypertension in circadian clock-deficient Cry-null mice involves dysregulated adrenal Hsd3b6 Salt-sensitive hypertension in circadian clock-deficient Cry-null mice involves dysregulated adrenal Hsd3b6 Nature Medicine, 16, 1, 67-74 , 16, 1, 67-74 Nature Medicine, 16, 1, 67-74 2010 Refereed English Disclose to all
J. Takahashi; I. Hijikuro; T. Kihara; M.G. Murugesh; S. Fuse; R. Kunimoto; Y. Tsumura; A. Akaike; T. Niidome; Y. Okuno; T. Takahashi; H. Sugimoto J. Takahashi; I. Hijikuro; T. Kihara; M.G. Murugesh; S. Fuse; R. Kunimoto; Y. Tsumura; A. Akaike; T. Niidome; Y. Okuno; T. Takahashi; H. Sugimoto Design, synthesis, evaluation and QSAR analysis of N<sup>1</sup>-substituted norcymserine derivatives as selective butyrylcholinesterase inhibitors Design, synthesis, evaluation and QSAR analysis of N<sup>1</sup>-substituted norcymserine derivatives as selective butyrylcholinesterase inhibitors Bioorganic and Medicinal Chemistry Letters, 20, 5, 1718-1720 , 20, 5, 1718-1720 Bioorganic and Medicinal Chemistry Letters, 20, 5, 1718-1720 2010 Refereed English Disclose to all
N. Terada; Y. Shimizu; T. Kamba; T. Inoue; A. Maeno; T. Kobayashi; E. Nakamura; T. Kamoto; T. Kanaji; T. Maruyama; Y. Mikami; Y. Toda; T. Matsuoka; Y. Okuno; G. Tsujimoto; S. Narumiya; O. Ogawa N. Terada; Y. Shimizu; T. Kamba; T. Inoue; A. Maeno; T. Kobayashi; E. Nakamura; T. Kamoto; T. Kanaji; T. Maruyama; Y. Mikami; Y. Toda; T. Matsuoka; Y. Okuno; G. Tsujimoto; S. Narumiya; O. Ogawa Identification of EP4 as a potential target for the treatment of castration-resistant prostate cancer using a novel xenograft model Identification of EP4 as a potential target for the treatment of castration-resistant prostate cancer using a novel xenograft model Cancer Research, 70, 4, 1606-1615 , 70, 4, 1606-1615 Cancer Research, 70, 4, 1606-1615 2010 Refereed English Disclose to all
M. Hagihara; K. Yoneda; H. Yabuuchi; Y. Okuno; K. Nakatani M. Hagihara; K. Yoneda; H. Yabuuchi; Y. Okuno; K. Nakatani A reverse transcriptase stop assay revealed diverse quadruplex formations in UTRs in mRNA A reverse transcriptase stop assay revealed diverse quadruplex formations in UTRs in mRNA Bioorganic and Medicinal Chemistry Letters, 20, 7, 2350-2353 , 20, 7, 2350-2353 Bioorganic and Medicinal Chemistry Letters, 20, 7, 2350-2353 2010 Refereed English Disclose to all
E. van der Horst; J.E. Peironcely; A.P. IJzerman; M.W. Beukers; J.R. Lane; H.W.T. van Vlijmen; M.T.M. Emmerich; Y. Okuno; A. Bender E. van der Horst; J.E. Peironcely; A.P. IJzerman; M.W. Beukers; J.R. Lane; H.W.T. van Vlijmen; M.T.M. Emmerich; Y. Okuno; A. Bender A novel chemogenomics analysis of G protein-coupled receptors (GPCRs) and their ligands: A potential strategy for receptor de-orphanization A novel chemogenomics analysis of G protein-coupled receptors (GPCRs) and their ligands: A potential strategy for receptor de-orphanization BMC Bioinformatics, 11 , 11 BMC Bioinformatics, 11 2010 Refereed English Disclose to all
M. Kusaka; Y. Katoh-Fukui; H. Ogawa; K. Miyabayashi; T. Baba; Y. Shima; N. Sugiyama; Y. Sugimoto; Y. Okuno; R. Kodama; A. Iizuka-Kogo; T. Senda; T. Sasaoka; K. Kitamura; S. Aizawa; K.-I. Morohashi M. Kusaka; Y. Katoh-Fukui; H. Ogawa; K. Miyabayashi; T. Baba; Y. Shima; N. Sugiyama; Y. Sugimoto; Y. Okuno; R. Kodama; A. Iizuka-Kogo; T. Senda; T. Sasaoka; K. Kitamura; S. Aizawa; K.-I. Morohashi Abnormal epithelial cell polarity and ectopic Epidermal Growth Factor Receptor (EGFR) expression induced in Emx2 KO Embryonic Gonads Abnormal epithelial cell polarity and ectopic Epidermal Growth Factor Receptor (EGFR) expression induced in Emx2 KO Embryonic Gonads Endocrinology, 151, 12, 5893-5904 , 151, 12, 5893-5904 Endocrinology, 151, 12, 5893-5904 2010 Refereed English Disclose to all
S. Niijima; Y. Okuno S. Niijima; Y. Okuno Laplacian linear discriminant analysis approach to unsupervised feature selection Laplacian linear discriminant analysis approach to unsupervised feature selection IEEE/ACM Transactions on Computational Biology and Bioinformatics, 6, 4, 605-614 , 6, 4, 605-614 IEEE/ACM Transactions on Computational Biology and Bioinformatics, 6, 4, 605-614 2009/10 Refereed English Disclose to all
S. Tsuchiya; M. Oku; Y. Imanaka; R. Kunimoto; Y. Okuno; K. Terasawa; F. Sato; G. Tsujimoto; K. Shimizu S. Tsuchiya; M. Oku; Y. Imanaka; R. Kunimoto; Y. Okuno; K. Terasawa; F. Sato; G. Tsujimoto; K. Shimizu MicroRNA-338-3p and microRNA-451 contribute to the formation of basolateral polarity in epithelial cells MicroRNA-338-3p and microRNA-451 contribute to the formation of basolateral polarity in epithelial cells Nucleic Acids Research, 37, 11, 3821-3827 , 37, 11, 3821-3827 Nucleic Acids Research, 37, 11, 3821-3827 2009/06 Refereed English Disclose to all
S. Tsuchiya; Y. Tachida; E. Segi-Nishida; Y. Okuno; S. Tamba; G. Tsujimoto; S. Tanaka; Y. Sugimoto S. Tsuchiya; Y. Tachida; E. Segi-Nishida; Y. Okuno; S. Tamba; G. Tsujimoto; S. Tanaka; Y. Sugimoto Characterization of gene expression profiles for different types of mast cells pooled from mouse stomach subregions by an RNA amplification method Characterization of gene expression profiles for different types of mast cells pooled from mouse stomach subregions by an RNA amplification method BMC Genomics, 10 , 10 BMC Genomics, 10 2009 Refereed English Disclose to all
E. Van Der Horst; Y. Okuno; A. Bender; A.P. IJzerman E. Van Der Horst; Y. Okuno; A. Bender; A.P. IJzerman Substructure mining of GPCR ligands reveals activity-class specific functional groups in an unbiased manner Substructure mining of GPCR ligands reveals activity-class specific functional groups in an unbiased manner Journal of Chemical Information and Modeling, 49, 2, 348-360 , 49, 2, 348-360 Journal of Chemical Information and Modeling, 49, 2, 348-360 2009 Refereed English Disclose to all
T. Ichimi; H. Enokida; Y. Okuno; R. Kunimoto; T. Chiyomaru; K. Kawamoto; K. Kawahara; K. Toki; K. Kawakami; K. Nishiyama; G. Tsujimoto; M. Nakagawa; N. Seki T. Ichimi; H. Enokida; Y. Okuno; R. Kunimoto; T. Chiyomaru; K. Kawamoto; K. Kawahara; K. Toki; K. Kawakami; K. Nishiyama; G. Tsujimoto; M. Nakagawa; N. Seki Identification of novel microRNA targets based on microRNA signatures in bladder cancer Identification of novel microRNA targets based on microRNA signatures in bladder cancer International Journal of Cancer, 125, 2, 345-352 , 125, 2, 345-352 International Journal of Cancer, 125, 2, 345-352 2009 Refereed English Disclose to all
C. Feng; M. Araki; R. Kunimoto; A. Tamon; H. Makiguchi; S. Niijima; G. Tsujimoto; Y. Okuno C. Feng; M. Araki; R. Kunimoto; A. Tamon; H. Makiguchi; S. Niijima; G. Tsujimoto; Y. Okuno GEM-TREND: A web tool for gene expression data mining toward relevant network discovery GEM-TREND: A web tool for gene expression data mining toward relevant network discovery BMC Genomics, 10 , 10 BMC Genomics, 10 2009 Refereed English Disclose to all
C. Kondo; Y. Minowa; T. Uehara; Y. Okuno; N. Nakatsu; A. Ono; T. Maruyama; I. Kato; J. Yamate; H. Yamada; Y. Ohno; T. Urushidani C. Kondo; Y. Minowa; T. Uehara; Y. Okuno; N. Nakatsu; A. Ono; T. Maruyama; I. Kato; J. Yamate; H. Yamada; Y. Ohno; T. Urushidani Identification of genomic biomarkers for concurrent diagnosis of drug-induced renal tubular injury using a large-scale toxicogenomics database Identification of genomic biomarkers for concurrent diagnosis of drug-induced renal tubular injury using a large-scale toxicogenomics database Toxicology, 265, 1-2, 15-26 , 265, 1-2, 15-26 Toxicology, 265, 1-2, 15-26 2009 Refereed English Disclose to all
Y. Ruike; A. Ichimura; S. Tsuchiya; K. Shimizu; R. Kunimoto; Y. Okuno; G. Tsujimoto Y. Ruike; A. Ichimura; S. Tsuchiya; K. Shimizu; R. Kunimoto; Y. Okuno; G. Tsujimoto Global correlation analysis for micro-RNA and mRNA expression profiles in human cell lines Global correlation analysis for micro-RNA and mRNA expression profiles in human cell lines Journal of Human Genetics, 53, 6, 515-523 , 53, 6, 515-523 Journal of Human Genetics, 53, 6, 515-523 2008/06 Refereed English Disclose to all
H. Takano; S. Nakazawa; Y. Okuno; N. Shirata; S. Tsuchiya; T. Kainoh; S. Takamatsu; K. Furuta; Y. Taketomi; Y. Naito; H. Takematsu; Y. Kozutsumi; G. Tsujimoto; M. Murakami; I. Kudo; A. Ichikawa; K. Nakayama; Y. Sugimoto; S. Tanaka H. Takano; S. Nakazawa; Y. Okuno; N. Shirata; S. Tsuchiya; T. Kainoh; S. Takamatsu; K. Furuta; Y. Taketomi; Y. Naito; H. Takematsu; Y. Kozutsumi; G. Tsujimoto; M. Murakami; I. Kudo; A. Ichikawa; K. Nakayama; Y. Sugimoto; S. Tanaka Establishment of the culture model system that reflects the process of terminal differentiation of connective tissue-type mast cells Establishment of the culture model system that reflects the process of terminal differentiation of connective tissue-type mast cells FEBS Letters, 582, 10, 1444-1450 , 582, 10, 1444-1450 FEBS Letters, 582, 10, 1444-1450 2008/04/30 Refereed English Disclose to all
Y. Okuno; A. Tamon; H. Yabuuchi; S. Niijima; Y. Minowa; K. Tonomura; R. Kunimoto; C. Feng Y. Okuno; A. Tamon; H. Yabuuchi; S. Niijima; Y. Minowa; K. Tonomura; R. Kunimoto; C. Feng GLIDA: GPCR - Ligand database for chemical genomics drug discovery - Database and tools update GLIDA: GPCR - Ligand database for chemical genomics drug discovery - Database and tools update Nucleic Acids Research, 36, 907-912 , 36, 907-912 Nucleic Acids Research, 36, 907-912 2008 Refereed English Disclose to all
M. Kitajima; Y. Minowa; H. Matsuda; Y. Okuno M. Kitajima; Y. Minowa; H. Matsuda; Y. Okuno Compound-transporter interaction studies using canonical correlation analysis Compound-transporter interaction studies using canonical correlation analysis Chem-Bio Informatics Journal, 7, 24-34 , 7, 24-34 Chem-Bio Informatics Journal, 7, 24-34 2008 Refereed English Disclose to all
H. Kawanishi; Y. Matsui; M. Ito; J. Watanabe; T. Takahashi; K. Nishizawa; H. Nishiyama; T. Kamoto; Y. Mikami; Y. Tanaka; G. Jung; H. Akiyama; H. Nobumasa; P. Guilford; A. Reeve; Y. Okuno; G. Tsujimoto; E. Nakamura; O. Ogawa H. Kawanishi; Y. Matsui; M. Ito; J. Watanabe; T. Takahashi; K. Nishizawa; H. Nishiyama; T. Kamoto; Y. Mikami; Y. Tanaka; G. Jung; H. Akiyama; H. Nobumasa; P. Guilford; A. Reeve; Y. Okuno; G. Tsujimoto; E. Nakamura; O. Ogawa Secreted CXCL1 Is a potential mediator and marker of the tumor invasion of bladder cancer Secreted CXCL1 Is a potential mediator and marker of the tumor invasion of bladder cancer Clinical Cancer Research, 14, 9, 2579-2587 , 14, 9, 2579-2587 Clinical Cancer Research, 14, 9, 2579-2587 2008 Refereed English Disclose to all
H. Yamamoto; H. Takematsu; R. Fujinawa; Y. Naito; Y. Okuno; G. Tsujimoto; A. Suzuki; Y. Kozutsumi H. Yamamoto; H. Takematsu; R. Fujinawa; Y. Naito; Y. Okuno; G. Tsujimoto; A. Suzuki; Y. Kozutsumi Correlation index-based responsible-enzyme gene screening (CIRES), a novel DNA microarray-based method for enzyme gene involved in glycan biosynthesis Correlation index-based responsible-enzyme gene screening (CIRES), a novel DNA microarray-based method for enzyme gene involved in glycan biosynthesis PLoS ONE, 2, 11 , 2, 11 PLoS ONE, 2, 11 2007/11/28 Refereed English Disclose to all
Y. Naito; H. Takematsu; S. Koyama; S. Miyake; H. Yamamoto; R. Fujinawa; M. Sugai; Y. Okuno; G. Tsujimoto; T. Yamaji; Y. Hashimoto; S. Itohara; T. Kawasaki; A. Suzuki; Y. Kozutsumi Y. Naito; H. Takematsu; S. Koyama; S. Miyake; H. Yamamoto; R. Fujinawa; M. Sugai; Y. Okuno; G. Tsujimoto; T. Yamaji; Y. Hashimoto; S. Itohara; T. Kawasaki; A. Suzuki; Y. Kozutsumi Germinal center marker GL7 probes activation-dependent repression of N-glycolylneuraminic acid, a sialic acid species involved in the negative modulation of B-cell activation Germinal center marker GL7 probes activation-dependent repression of N-glycolylneuraminic acid, a sialic acid species involved in the negative modulation of B-cell activation Molecular and Cellular Biology, 27, 8, 3008-3022 , 27, 8, 3008-3022 Molecular and Cellular Biology, 27, 8, 3008-3022 2007/04 Refereed English Disclose to all
T. Yamazaki; N. Sasaki; M. Nishi; D. Yamazaki; A. Ikeda; Y. Okuno; S. Komazaki; H. Takeshima T. Yamazaki; N. Sasaki; M. Nishi; D. Yamazaki; A. Ikeda; Y. Okuno; S. Komazaki; H. Takeshima Augmentation of drug-induced cell death by ER protein BRI3BP Augmentation of drug-induced cell death by ER protein BRI3BP Biochemical and Biophysical Research Communications, 362, 4, 971-975 , 362, 4, 971-975 Biochemical and Biophysical Research Communications, 362, 4, 971-975 2007 Refereed English Disclose to all
A. Ikeda; T. Miyazaki; S. Kakizawa; Y. Okuno; S. Tsuchiya; A. Myomoto; S.-y. Saito; T. Yamamoto; T. Yamazaki; M. Iino; G. Tsujimoto; M. Watanabe; H. Takeshima A. Ikeda; T. Miyazaki; S. Kakizawa; Y. Okuno; S. Tsuchiya; A. Myomoto; S.-y. Saito; T. Yamamoto; T. Yamazaki; M. Iino; G. Tsujimoto; M. Watanabe; H. Takeshima Abnormal features in mutant cerebellar Purkinje cells lacking junctophilins Abnormal features in mutant cerebellar Purkinje cells lacking junctophilins Biochemical and Biophysical Research Communications, 363, 3, 835-839 , 363, 3, 835-839 Biochemical and Biophysical Research Communications, 363, 3, 835-839 2007 Refereed English Disclose to all
Y. Okuno; J. Yang; K. Taneishi; H. Yabuuchi; G. Tsujimoto Y. Okuno; J. Yang; K. Taneishi; H. Yabuuchi; G. Tsujimoto GLIDA: GPCR-ligand database for chemical genomic drug discovery. GLIDA: GPCR-ligand database for chemical genomic drug discovery. Nucleic acids research., 34, Database issue, D673-677 , 34, Database issue, D673-677 Nucleic acids research., 34, Database issue, D673-677 2006 Refereed English Disclose to all
S. Tsuchiya; Y. Okuno; G. Tsujimoto S. Tsuchiya; Y. Okuno; G. Tsujimoto MicroRNA: Biogenetic and functional mechanisms and involvements in cell differentiation and cancer MicroRNA: Biogenetic and functional mechanisms and involvements in cell differentiation and cancer Journal of Pharmacological Sciences, 101, 4, 267-270 , 101, 4, 267-270 Journal of Pharmacological Sciences, 101, 4, 267-270 2006 Refereed English Disclose to all
S. Osada; A. Naganawa; M. Misonou; S. Tsuchiya; S. Tamba; Y. Okuno; J.-i. Nishikawa; K. Satoh; M. Imagawa; G. Tsujimoto; Y. Sugimoto; T. Nishihara S. Osada; A. Naganawa; M. Misonou; S. Tsuchiya; S. Tamba; Y. Okuno; J.-i. Nishikawa; K. Satoh; M. Imagawa; G. Tsujimoto; Y. Sugimoto; T. Nishihara Altered gene expression of transcriptional regulatory factors in tumor marker-positive cells during chemically induced hepatocarcinogenesis Altered gene expression of transcriptional regulatory factors in tumor marker-positive cells during chemically induced hepatocarcinogenesis Toxicology Letters, 167, 2, 106-113 , 167, 2, 106-113 Toxicology Letters, 167, 2, 106-113 2006 Refereed English Disclose to all
S. Zhu; Y. Okuno; G. Tsujimoto; H. Mamitsuka S. Zhu; Y. Okuno; G. Tsujimoto; H. Mamitsuka Application of a new probabilistic model for mining implicit associated cancer genes from OMIM and Medline Application of a new probabilistic model for mining implicit associated cancer genes from OMIM and Medline Cancer Informatics, 2, 361-371 , 2, 361-371 Cancer Informatics, 2, 361-371 2006 Refereed English Disclose to all
S. Zhu; Y. Okuno; G. Tsujimoto; H. Mamitsuka S. Zhu; Y. Okuno; G. Tsujimoto; H. Mamitsuka A probabilistic model for mining implicit \\'chemical compound-gene\\' relations from literature A probabilistic model for mining implicit \\'chemical compound-gene\\' relations from literature Bioinformatics, 21, 245-251 , 21, 245-251 Bioinformatics, 21, 245-251 2005/09 Refereed English Disclose to all
T. Adachi; Y. Okuno; S. Takenaka; K. Matsuda; N. Ohta; K. Takashima; K. Yamazaki; D. Nishimura; K. Miyatake; C. Mori; G. Tsujimoto T. Adachi; Y. Okuno; S. Takenaka; K. Matsuda; N. Ohta; K. Takashima; K. Yamazaki; D. Nishimura; K. Miyatake; C. Mori; G. Tsujimoto Comprehensive analysis of the effect of phytoestrogen, daidzein, on a testicular cell line, using mRNA and protein expression profile Comprehensive analysis of the effect of phytoestrogen, daidzein, on a testicular cell line, using mRNA and protein expression profile Food and Chemical Toxicology, 43, 4, 529-535 , 43, 4, 529-535 Food and Chemical Toxicology, 43, 4, 529-535 2005 Refereed English Disclose to all
Y. Sugimoto; Y. Fukada; D. Mori; S. Tanaka; H. Yamane; Y. Okuno; K. Deai; S. Tsuchiya; G. Tsujimoto; A. Ichikawa Y. Sugimoto; Y. Fukada; D. Mori; S. Tanaka; H. Yamane; Y. Okuno; K. Deai; S. Tsuchiya; G. Tsujimoto; A. Ichikawa Prostaglandin E<sub>2</sub> stimulates granulocyte colony-stimulating factor production via the prostanoid EP2 receptor in mouse peritoneal neutrophils Prostaglandin E<sub>2</sub> stimulates granulocyte colony-stimulating factor production via the prostanoid EP2 receptor in mouse peritoneal neutrophils Journal of Immunology, 175, 4, 2606-2612 , 175, 4, 2606-2612 Journal of Immunology, 175, 4, 2606-2612 2005 Refereed English Disclose to all
M. Kanehisa; S. Goto; S. Kawashima; Y. Okuno; M. Hattori M. Kanehisa; S. Goto; S. Kawashima; Y. Okuno; M. Hattori The KEGG resource for deciphering the genome The KEGG resource for deciphering the genome Nucleic Acids Research, 32, Database Issue, 277-280 , 32, Database Issue, 277-280 Nucleic Acids Research, 32, Database Issue, 277-280 2004 Refereed English Disclose to all
M. Kotera; Y. Okuno; M. Hattori; S. Goto; M. Kanehisa M. Kotera; Y. Okuno; M. Hattori; S. Goto; M. Kanehisa Computational assignment of the EC numbers for genomic-scale analysis of enzymatic reactions Computational assignment of the EC numbers for genomic-scale analysis of enzymatic reactions Journal of the American Chemical Society, 126, 50, 16487-16498 , 126, 50, 16487-16498 Journal of the American Chemical Society, 126, 50, 16487-16498 2004 Refereed English Disclose to all
Y. Sugimoto; H. Tsuboi; Y. Okuno; S. Tamba; S. Tsuchiya; G. Tsujimoto; A. Ichikawa Y. Sugimoto; H. Tsuboi; Y. Okuno; S. Tamba; S. Tsuchiya; G. Tsujimoto; A. Ichikawa Microarray evaluation of EP4 receptor-mediated prostaglandin E <sub>2</sub> suppression of 3T3-L1 adipocyte differentiation Microarray evaluation of EP4 receptor-mediated prostaglandin E <sub>2</sub> suppression of 3T3-L1 adipocyte differentiation Biochemical and Biophysical Research Communications, 322, 3, 911-917 , 322, 3, 911-917 Biochemical and Biophysical Research Communications, 322, 3, 911-917 2004 Refereed English Disclose to all
M. Hattori; Y. Okuno; S. Goto; M. Kanehisa M. Hattori; Y. Okuno; S. Goto; M. Kanehisa Development of a chemical structure comparison method for integrated analysis of chemical and genomic information in the metabolic pathways Development of a chemical structure comparison method for integrated analysis of chemical and genomic information in the metabolic pathways Journal of the American Chemical Society, 125, 39, 11853-11865 , 125, 39, 11853-11865 Journal of the American Chemical Society, 125, 39, 11853-11865 2003/10/01 Refereed English Disclose to all
S. Goto; Y. Okuno; M. Hattori; T. Nishioka; M. Kanehisa S. Goto; Y. Okuno; M. Hattori; T. Nishioka; M. Kanehisa LIGAND: Database of chemical compounds and reactions in biological pathways LIGAND: Database of chemical compounds and reactions in biological pathways Nucleic Acids Research, 30, 1, 402-404 , 30, 1, 402-404 Nucleic Acids Research, 30, 1, 402-404 2002/01/01 Refereed English Disclose to all
M. Araki; M. Hashima; Y. Okuno; Y. Sugiura M. Araki; M. Hashima; Y. Okuno; Y. Sugiura Coupling between substrate binding and allosteric regulation in ribozyme catalysis Coupling between substrate binding and allosteric regulation in ribozyme catalysis Bioorganic and Medicinal Chemistry, 9, 5, 1155-1163 , 9, 5, 1155-1163 Bioorganic and Medicinal Chemistry, 9, 5, 1155-1163 2001 Refereed English Disclose to all
Y. Hori; K. Suzuki; Y. Okuno; M. Nagaoka; S. Futaki; Y. Sugiura Y. Hori; K. Suzuki; Y. Okuno; M. Nagaoka; S. Futaki; Y. Sugiura Artificial zinc finger peptide containing a novel his<sub>4</sub> domain Artificial zinc finger peptide containing a novel his<sub>4</sub> domain Journal of the American Chemical Society, 122, 32, 7648-7653 , 122, 32, 7648-7653 Journal of the American Chemical Society, 122, 32, 7648-7653 2000/08/16 Refereed English Disclose to all
Y. Okuno; T. Iwashita; Y. Sugiura Y. Okuno; T. Iwashita; Y. Sugiura Structural basis for reaction mechanism and drug delivery system of chromoprotein antitumor antibiotic C-1027 Structural basis for reaction mechanism and drug delivery system of chromoprotein antitumor antibiotic C-1027 Journal of the American Chemical Society, 122, 29, 6848-6854 , 122, 29, 6848-6854 Journal of the American Chemical Society, 122, 29, 6848-6854 2000 Refereed English Disclose to all
M. Araki; Y. Okuno; Y. Hara; Y. Sugiura M. Araki; Y. Okuno; Y. Hara; Y. Sugiura Allosteric regulation of a ribozyme activity through ligand-induced conformational change Allosteric regulation of a ribozyme activity through ligand-induced conformational change Nucleic Acids Research, 26, 14, 3379-3384 , 26, 14, 3379-3384 Nucleic Acids Research, 26, 14, 3379-3384 1998 Refereed English Disclose to all
Y. Sugiura; R. Totsuka; M. Araki; Y. Okuno Y. Sugiura; R. Totsuka; M. Araki; Y. Okuno Selective cleavages of tRNA(Phe) with secondary and tertiary structures by enediyne antitumor antibiotics Selective cleavages of tRNA(Phe) with secondary and tertiary structures by enediyne antitumor antibiotics Bioorganic and Medicinal Chemistry, 5, 6, 1229-1234 , 5, 6, 1229-1234 Bioorganic and Medicinal Chemistry, 5, 6, 1229-1234 1997 Refereed English Disclose to all
Y. Okuno; T. Iwashita; T. Otani; Y. Sugiura Y. Okuno; T. Iwashita; T. Otani; Y. Sugiura Interaction of C-1027 chromophore with d(GTATAC)<sub>2</sub>: A binding model based on NMR experiments Interaction of C-1027 chromophore with d(GTATAC)<sub>2</sub>: A binding model based on NMR experiments Journal of the American Chemical Society, 118, 19, 4729-4730 , 118, 19, 4729-4730 Journal of the American Chemical Society, 118, 19, 4729-4730 1996 Refereed English Disclose to all
R. Totsuka; Y. Aizawa; M. Uesugi; Y. Okuno; T. Matsumoto; Y. Sugiura R. Totsuka; Y. Aizawa; M. Uesugi; Y. Okuno; T. Matsumoto; Y. Sugiura RNA cleavage by C-1027 chromophore, an enediyne antitumor antibiotic: High selectivity to an anticodon arm RNA cleavage by C-1027 chromophore, an enediyne antitumor antibiotic: High selectivity to an anticodon arm Biochemical and Biophysical Research Communications, 208, 1, 168-173 , 208, 1, 168-173 Biochemical and Biophysical Research Communications, 208, 1, 168-173 1995/03/08 Refereed English Disclose to all
Y. Okuno; M. Otsuka; Y. Sugiura Y. Okuno; M. Otsuka; Y. Sugiura Computer modeling analysis for enediyne chromophore-apoprotein complex of macromolecular antitumor antibiotic C-1027 Computer modeling analysis for enediyne chromophore-apoprotein complex of macromolecular antitumor antibiotic C-1027 Journal of Medicinal Chemistry, 37, 15, 2266-2273 , 37, 15, 2266-2273 Journal of Medicinal Chemistry, 37, 15, 2266-2273 1994 Refereed English Disclose to all
T. Matsumoto; Y. Okuno; Y. Sugiura T. Matsumoto; Y. Okuno; Y. Sugiura Specific interaction between a novel enediyne chromophore and apoprotein in macromolecular antitumor antibiotic C-1027 Specific interaction between a novel enediyne chromophore and apoprotein in macromolecular antitumor antibiotic C-1027 Biochemical and Biophysical Research Communications, 195, 2, 659-666 , 195, 2, 659-666 Biochemical and Biophysical Research Communications, 195, 2, 659-666 1993 Refereed English Disclose to all

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Title language:
Misc
Author Author(Japanese) Author(English) Title Title(Japanese) Title(English) Bibliography Bibliography(Japanese) Bibliography(English) Publication date Refereed paper Language Publishing type Disclose
J.B. Brown; S. Niijima; A. Shiraishi; M. Nakatsui; Y. Okuno J.B. Brown; S. Niijima; A. Shiraishi; M. Nakatsui; Y. Okuno Chemogenomic approach to comprehensive predictions of ligand-target interactions: A comparative study Chemogenomic approach to comprehensive predictions of ligand-target interactions: A comparative study Proceedings - 2012 IEEE International Conference on Bioinformatics and Biomedicine Workshops, BIBMW 2012, 136-142 , 136-142 Proceedings - 2012 IEEE International Conference on Bioinformatics and Biomedicine Workshops, BIBMW 2012, 136-142 2012 Refereed English Disclose to all
T. Inoue; Y. Kado; K. Tokuoka; H. Matsumura; Y. Kai; Y. Mori; H. Adachi; K. Takano; S. Murakami; Y. Fukunishi; H. Nakamura; T. Kinoshita; I. Nakanishi; Y. Okuno; S. Minakata; T. Sakata T. Inoue; Y. Kado; K. Tokuoka; H. Matsumura; Y. Kai; Y. Mori; H. Adachi; K. Takano; S. Murakami; Y. Fukunishi; H. Nakamura; T. Kinoshita; I. Nakanishi; Y. Okuno; S. Minakata; T. Sakata Drug development value chain constructed by collaboration between the SOSHO project and the NPO BIOGRID Drug development value chain constructed by collaboration between the SOSHO project and the NPO BIOGRID AIP Conference Proceedings, 85-88 , 85-88 AIP Conference Proceedings, 85-88 2007 Refereed English Disclose to all
M. Yamada; S. Katsuma; T. Adachi; A. Hirasawa; S. Shiojima; T. Kadowaki; Y. Okuno; T.-A. Koshimizu; S. Fujii; Y. Sekiya; Y. Miyamoto; M. Tamura; W. Yumura; H. Nihei; M. Kobayashi; G. Tsujimoto M. Yamada; S. Katsuma; T. Adachi; A. Hirasawa; S. Shiojima; T. Kadowaki; Y. Okuno; T.-A. Koshimizu; S. Fujii; Y. Sekiya; Y. Miyamoto; M. Tamura; W. Yumura; H. Nihei; M. Kobayashi; G. Tsujimoto Inhibition of protein kinase CK2 prevents the progression of glomerulonephritis Inhibition of protein kinase CK2 prevents the progression of glomerulonephritis Proceedings of the National Academy of Sciences of the United States of America, 102, 21, 7736-7741 , 102, 21, 7736-7741 Proceedings of the National Academy of Sciences of the United States of America, 102, 21, 7736-7741 2005/05/24 Refereed English Disclose to all
H. Mamitsuka; Y. Okuno H. Mamitsuka; Y. Okuno A hierarchical mixture of markov models for finding biologically active metabolic paths using gene expression and protein classes A hierarchical mixture of markov models for finding biologically active metabolic paths using gene expression and protein classes Proceedings - 2004 IEEE Computational Systems Bioinformatics Conference, CSB 2004, 341-352 , 341-352 Proceedings - 2004 IEEE Computational Systems Bioinformatics Conference, CSB 2004, 341-352 2004 Refereed English Disclose to all
M. Hattori; Y. Okuno; S. Goto; M. Kanehisa M. Hattori; Y. Okuno; S. Goto; M. Kanehisa Heuristics for chemical compound matching. Heuristics for chemical compound matching. Genome informatics series : proceedings of the . Workshop on Genome Informatics. Workshop on Genome Informatics, 14, 144-153 , 14, 144-153 Genome informatics series : proceedings of the . Workshop on Genome Informatics. Workshop on Genome Informatics, 14, 144-153 2003 Refereed English Disclose to all
K.F. Aoki; A. Yamaguchi; Y. Okuno; T. Akutsu; N. Ueda; M. Kanehisa; H. Mamitsuka K.F. Aoki; A. Yamaguchi; Y. Okuno; T. Akutsu; N. Ueda; M. Kanehisa; H. Mamitsuka Efficient tree-matching methods for accurate carbohydrate database queries. Efficient tree-matching methods for accurate carbohydrate database queries. Genome informatics series : proceedings of the . Workshop on Genome Informatics. Workshop on Genome Informatics, 14, 134-143 , 14, 134-143 Genome informatics series : proceedings of the . Workshop on Genome Informatics. Workshop on Genome Informatics, 14, 134-143 2003 Refereed English Disclose to all
Y. Hori; K. Suzuki; Y. Okuno; M. Nagaoka; S. Futaki; Y. Sugiura Y. Hori; K. Suzuki; Y. Okuno; M. Nagaoka; S. Futaki; Y. Sugiura The engineering, structure, and DNA binding properties of a novel His4-type zinc finger peptide. The engineering, structure, and DNA binding properties of a novel His4-type zinc finger peptide. Nucleic acids symposium series, 44, 295-296 , 44, 295-296 Nucleic acids symposium series, 44, 295-296 2000 Refereed English Disclose to all
M. Araki; Y. Okuno; Y. Sugiura M. Araki; Y. Okuno; Y. Sugiura Expression mechanism of the allosteric interactions in a ribozyme catalysis. Expression mechanism of the allosteric interactions in a ribozyme catalysis. Nucleic acids symposium series, 44, 205-206 , 44, 205-206 Nucleic acids symposium series, 44, 205-206 2000 Refereed English Disclose to all
Title language:
Conference Activities & Talks
Title Title(Japanese) Title(English) Conference Conference(Japanese) Conference(English) Promotor Promotor(Japanese) Promotor(English) Date Language Assortment Disclose
オミックス創薬への新展開 オミックス創薬への新展開 第84回日本生化学会大会 シンポジウム 第84回日本生化学会大会 シンポジウム 日本生化学会 日本生化学会 2011/09/24 Japanese Oral presentation(invited, special) Disclose to all
情報科学から生命科学へ:目に観えるものだけが真実では無い 情報科学から生命科学へ:目に観えるものだけが真実では無い 京都大学化学研究所 生体反応設計セミナー 京都大学化学研究所 生体反応設計セミナー 京都大学化学研究所 京都大学化学研究所 2011/09/10 Japanese Oral presentation(invited, special) Disclose to all
立体構造情報に依存しないインシリコ創薬の現状と可能性 立体構造情報に依存しないインシリコ創薬の現状と可能性 プロテイン・モール関西・情報交流セミナー プロテイン・モール関西・情報交流セミナー 蛋白質科学会 蛋白質科学会 2011/06/09 Japanese Oral presentation(invited, special) Disclose to all
Title language:
Awards
Title(Japanese) Title(English) Organization name(Japanese) Organization name(English) Date
平成23年 第43回市村学術賞 貢献賞 財団法人新技術開発財団 2011/04/28
平成21年度文部科学大臣表彰 科学技術賞 科学技術振興部門 受賞 文部科学省 2009/04/14
平成20年「第8回バイオビジネスコンペJAPAN」 優秀賞 バイオビジネスコンペJAPAN委員会 2008/06/03
平成20年度日本薬学会 奨励賞 日本薬学会 2008/03/25
External funds, competitive funds and Grants-in-Aid for Scientific Research(kaken)
Type Position Title(Japanese) Title(English) Period
挑戦的萌芽研究 次世代型創薬「ネットワーク創薬」の創成 2009-2010
新学術領域研究 小分子ー生体システム相互作用の分子階層における統合的解析 2010-2014
研究成果データベース Gタンパク質共役型受容体—リガンド相互作用データベース -
研究成果公開促進費(データベース) Gタンパク質共役型受容体ーリガント作用 2010-2010
若手研究(A) ケミカルゲノミクスに基づく創薬インフォマティクスの開拓 2010-2012
データベース Representative Gタンパク質共役型受容体_リガインド相互作用データベース -
研究成果データベース Representative Gタンパク質共役型受容体―リガンド相互作用データベース -
Non-external, competitive funds or grants other than grants-in-aid for Scientific research (kaken)
System Main person Title(Japanese) Title(English) Period
ゲノム創薬のためのインフォマティクス研究 Informatics of Genomic Drug Discovery 2002-
最先端・次世代研究開発支援プログラム 奥野 恭史 新薬創出を加速化するインシリコ創薬基盤の確立 2010-2013
Teaching subject(s)
Name(Japanese) Name(English) Term Department Period
基礎バイオインフォマティクス 前期 薬学部 2011/04-2012/03
医薬品開発学 前期 薬学部 2011/04-2012/03
応用バイオインフォマティクス 前期 薬学部 2011/04-2012/03
医薬品開発学 Pharmaceutical R&D 前期 薬学部 2012/04-2013/03
博士後期課程特論 doctoral program 前期集中 薬学研究科 2012/04-2013/03
博士後期課程特論 doctoral program 後期集中 薬学研究科 2012/04-2013/03
基礎バイオインフォマティクス Introduction to Bioinformatics 前期 薬学部 2012/04-2013/03
応用バイオインフォマティクス Bioinformatics and Biocomputing 前期 薬学部 2012/04-2013/03
分子生物学実習 Experimental Practice in Molecular Biology 後期 医学部(人間健康科学科) 2013/04-2014/03
遺伝子検査技術学 Genetic Testing 前期後半 医学部(人間健康科学科) 2013/04-2014/03
遺伝子検査技術学実習 Training for Genetic Testin 後期 医学部(人間健康科学科) 2013/04-2014/03
分子生物・遺伝子検査解析学 Molecular Biology 前期後半 医学部(人間健康科学科) 2013/04-2014/03
分子生物・遺伝子検査解析学実習 Experimental Practice in Molecular Biology 後期 医学部(人間健康科学科) 2013/04-2014/03
基礎バイオインフォマティクス Introduction to Bioinformatics 前期 薬学部 2013/04-2014/03
医薬品開発学 Pharmaceutical R&D 前期 薬学部 2013/04-2014/03
博士後期課程特論 doctoral program 前期集中 薬学研究科 2013/04-2014/03
博士後期課程特論 doctoral program 後期集中 薬学研究科 2013/04-2014/03
分子生物学実習 Experimental Practice in Molecular Biology 後期 医学部(人間健康科学科) 2014/04-2015/03
遺伝子検査技術学 Genetic Testing 前期後半 医学部(人間健康科学科) 2014/04-2015/03
遺伝子検査技術学実習 Training for Genetic Testin 後期 医学部(人間健康科学科) 2014/04-2015/03
分子生物・遺伝子検査解析学 Molecular Biology 前期後半 医学部(人間健康科学科) 2014/04-2015/03
分子生物・遺伝子検査解析学実習 Experimental Practice in Molecular Biology 後期 医学部(人間健康科学科) 2014/04-2015/03
基礎バイオインフォマティクス Introduction to Bioinformatics 前期 薬学部 2014/04-2015/03
分子生物・遺伝子検査解析学 Molecular Biology 前期後半 医学部(人間健康科学科) 2015/04-2016/03
分子生物・遺伝子検査解析学実習 Experimental Practice in Molecular Biology 後期 医学部(人間健康科学科) 2015/04-2016/03
基礎バイオインフォマティクス Introduction to Bioinformatics 前期 薬学部 2015/04-2016/03
分子生物・遺伝子検査解析学実習 Experimental Practice in Molecular Biology 後期 医学部(人間健康科学科) 2016/04-2017/03
基礎バイオインフォマティクス Introduction to Bioinformatics 前期 薬学部 2016/04-2017/03
人間健康科学特論 Applied Human Health Sciences 前期 医学研究科(人間健康科学系専攻) 2017/04-2018/03
健康科学II Health Science II 前期 全学共通科目 2017/04-2018/03
分子生物・遺伝子検査解析学実習 Experimental Practice in Molecular Biology 後期 医学部(人間健康科学科) 2017/04-2018/03
基礎バイオインフォマティクス Introduction to Bioinformatics 前期 薬学部 2017/04-2018/03
慢性看護学特論 III Chronic Care Nursing III 前期 医学研究科(人間健康科学系専攻) 2018/04-2019/03
健康科学II Health Science II 前期 全学共通科目 2018/04-2019/03
健康科学II Health Science II 後期 全学共通科目 2018/04-2019/03
ビッグデータ医科学総論 Big data science in medicine 後期前半 医学部(人間健康科学科) 2018/04-2019/03
基礎バイオインフォマティクス Introduction to Bioinformatics 前期 薬学部 2018/04-2019/03

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Faculty management (title, position)
Title Period
広報委員会(委員長) 2017/04/01-2019/03/31
紀要編集委員会 2017/04/01-2019/03/31
医学研究科広報委員会 2016/10/01-2020/09/30
病院協議会 2016/08/01-
医療情報AIシステム学講座 運営委員会 2018/01/01-2020/03/31
ネットワークWG 2017/04/01-2019/03/31
情報セキュリティWG 2017/07/20-
医学部附属病院 先制医療・生活習慣病研究 センター評価委員会 2018/01/01-2020/12/31