大串 雅俊

Last Update: 2020/07/08 09:35:55

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Name(Kanji/Kana/Abecedarium Latinum)
大串 雅俊/オオグシ マサトシ/Ohgushi, Masatoshi
Primary Affiliation(Org1/Job title)
Institute for Frontier Life and Medical Sciences/Associate Professor
Academic Degree
Field(Japanese) Field(English) University(Japanese) University(English) Method
修士(生命科学) 京都大学
博士(生命科学) 京都大学
ORCID ID
https://orcid.org/0000-0002-1293-4893
researchmap URL
https://researchmap.jp/read0110981
Research Topics
(Japanese)
ヒト多能性幹細胞の性状解析と応用
(English)
Characterization and application of human pluripotent stem cells
Overview of the research
(Japanese)
ヒトES/iPS細胞は生体を構成するあらゆる細胞へ分化するポテンシャルを有した多能性幹細胞であり、その特性から医療・産業的に有用な細胞材料のリソースとして期待されている。これらヒト多能性幹細胞の有用性をさらに拡大させるため、より詳細な性状解析、分化特性検討などに取り組んでいる。
(English)
Human pluripotent stem cells, including embryonic stem cells and induced pluripotent stem cells, hold hold huge potential as reproductive resources for cell-therapies as well as for drug discovery. In order to further expand thier applications, we are working on detailed analyses of pluripotency and differentiation potency of human pluripotent stem cells.
Fields of research (key words)
Key words(Japanese) Key words(English)
ヒト多能性幹細胞 human embryonic stem cells
細胞分化 differentiation
初期発生 development
Published Papers
Author Author(Japanese) Author(English) Title Title(Japanese) Title(English) Bibliography Bibliography(Japanese) Bibliography(English) Publication date Refereed paper Language Publishing type Disclose
OGUSHI Masatoshi Ohgushi Masatoshi OGUSHI Masatoshi A Practical Protocol for the Conditional Depletion of Rho Isoforms in Human Embryonic Stem Cells. A Practical Protocol for the Conditional Depletion of Rho Isoforms in Human Embryonic Stem Cells. A Practical Protocol for the Conditional Depletion of Rho Isoforms in Human Embryonic Stem Cells. Methods in Molecular Biology, 1821, 283-295 Methods in Molecular Biology, 1821, 283-295 Methods in Molecular Biology, 1821, 283-295 2018/07 Refereed English Research paper(scientific journal) Disclose to all
Masatoshi Ohgushi, Maki Minaguchi, Mototsugu Eiraku, Yoshiki Sasai Masatoshi Ohgushi, Maki Minaguchi, Mototsugu Eiraku, Yoshiki Sasai Masatoshi Ohgushi, Maki Minaguchi, Mototsugu Eiraku, Yoshiki Sasai A RHO Small GTPase Regulator ABR Secures Mitotic Fidelity in Human Embryonic Stem Cells A RHO Small GTPase Regulator ABR Secures Mitotic Fidelity in Human Embryonic Stem Cells A RHO Small GTPase Regulator ABR Secures Mitotic Fidelity in Human Embryonic Stem Cells STEM CELL REPORTS, 9, 1, 58-66 STEM CELL REPORTS, 9, 1, 58-66 STEM CELL REPORTS, 9, 1, 58-66 2017/07 Refereed English Research paper(scientific journal) Disclose to all
Hideya Sakaguchi, Taisuke Kadoshima, Mika Soen, Nobuhiro Narii, Yoshihito Ishida, Masatoshi Ohgushi, Jun Takahashi, Mototsugu Eiraku, Yoshiki Sasai Hideya Sakaguchi, Taisuke Kadoshima, Mika Soen, Nobuhiro Narii, Yoshihito Ishida, Masatoshi Ohgushi, Jun Takahashi, Mototsugu Eiraku, Yoshiki Sasai Hideya Sakaguchi, Taisuke Kadoshima, Mika Soen, Nobuhiro Narii, Yoshihito Ishida, Masatoshi Ohgushi, Jun Takahashi, Mototsugu Eiraku, Yoshiki Sasai Generation of functional hippocampal neurons from self-organizing human embryonic stem cell-derived dorsomedial telencephalic tissue Generation of functional hippocampal neurons from self-organizing human embryonic stem cell-derived dorsomedial telencephalic tissue Generation of functional hippocampal neurons from self-organizing human embryonic stem cell-derived dorsomedial telencephalic tissue NATURE COMMUNICATIONS, 6, 8896 NATURE COMMUNICATIONS, 6, 8896 NATURE COMMUNICATIONS, 6, 8896 2015/11 Refereed English Research paper(scientific journal) Disclose to all
Masatoshi Ohgushi, Maki Minaguchi, Yoshiki Sasai Masatoshi Ohgushi, Maki Minaguchi, Yoshiki Sasai Masatoshi Ohgushi, Maki Minaguchi, Yoshiki Sasai Rho-Signaling-Directed YAP/TAZ Activity Underlies the Long-Term Survival and Expansion of Human Embryonic Stem Cells Rho-Signaling-Directed YAP/TAZ Activity Underlies the Long-Term Survival and Expansion of Human Embryonic Stem Cells Rho-Signaling-Directed YAP/TAZ Activity Underlies the Long-Term Survival and Expansion of Human Embryonic Stem Cells CELL STEM CELL, 17, 4, 448-461 CELL STEM CELL, 17, 4, 448-461 CELL STEM CELL, 17, 4, 448-461 2015/10 Refereed English Research paper(scientific journal) Disclose to all
Fukusumi H, Shofuda T, Kanematsu D, Yamamoto A, Suemizu H, Nakamura M, Yamasaki M, Ohgushi M, Sasai Y, Kanemura Y Fukusumi H, Shofuda T, Kanematsu D, Yamamoto A, Suemizu H, Nakamura M, Yamasaki M, Ohgushi M, Sasai Y, Kanemura Y Fukusumi H, Shofuda T, Kanematsu D, Yamamoto A, Suemizu H, Nakamura M, Yamasaki M, Ohgushi M, Sasai Y, Kanemura Y Feeder-free generation and long-term culture of human induced pluripotent stem cells using pericellular matrix of decidua derived mesenchymal cells. Feeder-free generation and long-term culture of human induced pluripotent stem cells using pericellular matrix of decidua derived mesenchymal cells. Feeder-free generation and long-term culture of human induced pluripotent stem cells using pericellular matrix of decidua derived mesenchymal cells. PloS one, 8, 1, e55226 PloS one, 8, 1, e55226 PloS one, 8, 1, e55226 2013 Refereed Disclose to all
Hidetaka Suga, Taisuke Kadoshima, Maki Minaguchi, Masatoshi Ohgushi, Mika Soen, Tokushige Nakano, Nozomu Takata, Takafumi Wataya, Keiko Muguruma, Hiroyuki Miyoshi, Shigenobu Yonemura, Yutaka Oiso, Yoshiki Sasai Hidetaka Suga, Taisuke Kadoshima, Maki Minaguchi, Masatoshi Ohgushi, Mika Soen, Tokushige Nakano, Nozomu Takata, Takafumi Wataya, Keiko Muguruma, Hiroyuki Miyoshi, Shigenobu Yonemura, Yutaka Oiso, Yoshiki Sasai Hidetaka Suga, Taisuke Kadoshima, Maki Minaguchi, Masatoshi Ohgushi, Mika Soen, Tokushige Nakano, Nozomu Takata, Takafumi Wataya, Keiko Muguruma, Hiroyuki Miyoshi, Shigenobu Yonemura, Yutaka Oiso, Yoshiki Sasai Self-formation of functional adenohypophysis in three-dimensional culture Self-formation of functional adenohypophysis in three-dimensional culture Self-formation of functional adenohypophysis in three-dimensional culture NATURE, 480, 7375, 57-U215 NATURE, 480, 7375, 57-U215 NATURE, 480, 7375, 57-U215 2011/12 Refereed English Research paper(scientific journal) Disclose to all
Masatoshi Ohgushi, Yoshiki Sasai Masatoshi Ohgushi, Yoshiki Sasai Masatoshi Ohgushi, Yoshiki Sasai Lonely death dance of human pluripotent stem cells: ROCKing between metastable cell states Lonely death dance of human pluripotent stem cells: ROCKing between metastable cell states Lonely death dance of human pluripotent stem cells: ROCKing between metastable cell states TRENDS IN CELL BIOLOGY, 21, 5, 274-282 TRENDS IN CELL BIOLOGY, 21, 5, 274-282 TRENDS IN CELL BIOLOGY, 21, 5, 274-282 2011/05 Refereed English Disclose to all
Daisuke Kamiya, Satoe Banno, Noriaki Sasai, Masatoshi Ohgushi, Hidehiko Inomata, Kiichi Watanabe, Masako Kawada, Rieko Yakura, Hiroshi Kiyonari, Kazuki Nakao, Lars Martin Jakt, Shin-ichi Nishikawa, Yoshiki Sasai Daisuke Kamiya, Satoe Banno, Noriaki Sasai, Masatoshi Ohgushi, Hidehiko Inomata, Kiichi Watanabe, Masako Kawada, Rieko Yakura, Hiroshi Kiyonari, Kazuki Nakao, Lars Martin Jakt, Shin-ichi Nishikawa, Yoshiki Sasai Daisuke Kamiya, Satoe Banno, Noriaki Sasai, Masatoshi Ohgushi, Hidehiko Inomata, Kiichi Watanabe, Masako Kawada, Rieko Yakura, Hiroshi Kiyonari, Kazuki Nakao, Lars Martin Jakt, Shin-ichi Nishikawa, Yoshiki Sasai Intrinsic transition of embryonic stem-cell differentiation into neural progenitors. Intrinsic transition of embryonic stem-cell differentiation into neural progenitors. Intrinsic transition of embryonic stem-cell differentiation into neural progenitors. Nature, 470, 7335, 503-9 Nature, 470, 7335, 503-9 Nature, 470, 7335, 503-9 2011/02/24 Refereed English Disclose to all
Masatoshi Ohgushi, Michiru Matsumura, Mototsugu Eiraku, Kazuhiro Murakami, Toshihiro Aramaki, Ayaka Nishiyama, Keiko Muguruma, Tokushige Nakano, Hidetaka Suga, Mono Ueno, Toshimasa Ishizaki, Hirofumi Suemori, Shuh Narumiya, Hitoshi Niwa, Yoshiki Sasai Masatoshi Ohgushi, Michiru Matsumura, Mototsugu Eiraku, Kazuhiro Murakami, Toshihiro Aramaki, Ayaka Nishiyama, Keiko Muguruma, Tokushige Nakano, Hidetaka Suga, Mono Ueno, Toshimasa Ishizaki, Hirofumi Suemori, Shuh Narumiya, Hitoshi Niwa, Yoshiki Sasai Masatoshi Ohgushi, Michiru Matsumura, Mototsugu Eiraku, Kazuhiro Murakami, Toshihiro Aramaki, Ayaka Nishiyama, Keiko Muguruma, Tokushige Nakano, Hidetaka Suga, Mono Ueno, Toshimasa Ishizaki, Hirofumi Suemori, Shuh Narumiya, Hitoshi Niwa, Yoshiki Sasai Molecular Pathway and Cell State Responsible for Dissociation-Induced Apoptosis in Human Pluripotent Stem Cells Molecular Pathway and Cell State Responsible for Dissociation-Induced Apoptosis in Human Pluripotent Stem Cells Molecular Pathway and Cell State Responsible for Dissociation-Induced Apoptosis in Human Pluripotent Stem Cells CELL STEM CELL, 7, 2, 225-239 CELL STEM CELL, 7, 2, 225-239 CELL STEM CELL, 7, 2, 225-239 2010/08 Refereed English Research paper(scientific journal) Disclose to all
Tomoko Nagase, Morio Ueno, Michiru Matsumura, Keiko Muguruma, Masatoshi Ohgushi, Naomi Kondo, Daisuke Kanematsu, Yonehiro Kanemura, Yoshiki Sasai Tomoko Nagase, Morio Ueno, Michiru Matsumura, Keiko Muguruma, Masatoshi Ohgushi, Naomi Kondo, Daisuke Kanematsu, Yonehiro Kanemura, Yoshiki Sasai Tomoko Nagase, Morio Ueno, Michiru Matsumura, Keiko Muguruma, Masatoshi Ohgushi, Naomi Kondo, Daisuke Kanematsu, Yonehiro Kanemura, Yoshiki Sasai Pericellular Matrix of Decidua-Derived Mesenchymal Cells: A Potent Human-Derived Substrate for the Maintenance Culture of Human ES Cells Pericellular Matrix of Decidua-Derived Mesenchymal Cells: A Potent Human-Derived Substrate for the Maintenance Culture of Human ES Cells Pericellular Matrix of Decidua-Derived Mesenchymal Cells: A Potent Human-Derived Substrate for the Maintenance Culture of Human ES Cells DEVELOPMENTAL DYNAMICS, 238, 5, 1118-1130 DEVELOPMENTAL DYNAMICS, 238, 5, 1118-1130 DEVELOPMENTAL DYNAMICS, 238, 5, 1118-1130 2009/05 Refereed English Research paper(scientific journal) Disclose to all
Yoshiki Sasai, Masatoshi Ogushi, Tomoko Nagase, Satoshi Ando Yoshiki Sasai, Masatoshi Ogushi, Tomoko Nagase, Satoshi Ando Yoshiki Sasai, Masatoshi Ogushi, Tomoko Nagase, Satoshi Ando Bridging the gap from frog research to human therapy: A tale of neural differentiation in Xenopus animal caps and human pluripotent cells Bridging the gap from frog research to human therapy: A tale of neural differentiation in Xenopus animal caps and human pluripotent cells Bridging the gap from frog research to human therapy: A tale of neural differentiation in Xenopus animal caps and human pluripotent cells DEVELOPMENT GROWTH & DIFFERENTIATION, 50, S47-S55 DEVELOPMENT GROWTH & DIFFERENTIATION, 50, S47-S55 DEVELOPMENT GROWTH & DIFFERENTIATION, 50, S47-S55 2008/06 Refereed English Disclose to all
M Ohgushi, S Kuroki, H Fukamachi, LA O'Reilly, K Kuida, A Strasser, S Yonehara M Ohgushi, S Kuroki, H Fukamachi, LA O'Reilly, K Kuida, A Strasser, S Yonehara M Ohgushi, S Kuroki, H Fukamachi, LA O'Reilly, K Kuida, A Strasser, S Yonehara Transforming growth factor beta-dependent sequential activation of Smad, Bim, and caspase-9 mediates physiological apoptosis in gastric epithelial cells Transforming growth factor beta-dependent sequential activation of Smad, Bim, and caspase-9 mediates physiological apoptosis in gastric epithelial cells Transforming growth factor beta-dependent sequential activation of Smad, Bim, and caspase-9 mediates physiological apoptosis in gastric epithelial cells MOLECULAR AND CELLULAR BIOLOGY, 25, 22, 10017-10028 MOLECULAR AND CELLULAR BIOLOGY, 25, 22, 10017-10028 MOLECULAR AND CELLULAR BIOLOGY, 25, 22, 10017-10028 2005/11 Refereed English Research paper(scientific journal) Disclose to all
T Imai, S Adachi, K Nishijo, M Ohgushi, M Okada, T Yasumi, K Watanabe, R Nishikomori, T Nakayama, S Yonehara, J Toguchida, T Nakahata T Imai, S Adachi, K Nishijo, M Ohgushi, M Okada, T Yasumi, K Watanabe, R Nishikomori, T Nakayama, S Yonehara, J Toguchida, T Nakahata T Imai, S Adachi, K Nishijo, M Ohgushi, M Okada, T Yasumi, K Watanabe, R Nishikomori, T Nakayama, S Yonehara, J Toguchida, T Nakahata FR901228 induces tumor regression associated with induction of Fas ligand and activation of Fas signaling in human osteosarcoma cells FR901228 induces tumor regression associated with induction of Fas ligand and activation of Fas signaling in human osteosarcoma cells FR901228 induces tumor regression associated with induction of Fas ligand and activation of Fas signaling in human osteosarcoma cells ONCOGENE, 22, 58, 9231-9242 ONCOGENE, 22, 58, 9231-9242 ONCOGENE, 22, 58, 9231-9242 2003/12 Refereed English Research paper(scientific journal) Disclose to all

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External funds: competitive funds and Grants-in-Aid for Scientific Research (Kakenhi)
Type Position Title(Japanese) Title(English) Period
基盤研究C Representative ヒト多能性幹細胞維持における細胞間コミュニケーションの役割と新規情報伝達機構解析 (平成29年度分) 2017/04/01-2018/03/31
基盤研究(C) Representative ヒト多能性幹細胞維持における細胞間コミュニケーションの役割と新規情報伝達機構解析 (平成30年度分) 2018/04/01-2019/03/31
基盤研究(C) Representative ヒト多能性幹細胞維持における細胞間コミュニケーションの役割と新規情報伝達機構解析 (2019年度分) 2019/04/01-2020/03/31
Teaching subject(s)
Name(Japanese) Name(English) Term Department Period
化学生物学 Chemical Biology 後期 工学部 2018/04-2019/03
生命医科学 Life and Medical Sciences 前期 工学研究科 2018/04-2019/03
生命医科学特論 Life and Medical Sciences, Adv. 前期 工学研究科 2018/04-2019/03
化学生物学 Chemical Biology 後期 工学部 2019/04-2020/03
生命医科学 Life and Medical Sciences 前期 工学研究科 2019/04-2020/03
生命医科学特論 Life and Medical Sciences, Adv. 前期 工学研究科 2019/04-2020/03
ILASセミナー:発生再生ゼミナール ILAS Seminar :Seminar on Developmental Biology and Regenerative Medicine 前期 全学共通科目 2020/04-2021/03
化学生物学 Chemical Biology 後期 工学部 2020/04-2021/03
生命医科学 Life and Medical Sciences 前期 工学研究科 2020/04-2021/03
生命医科学特論 Life and Medical Sciences, Adv. 前期 工学研究科 2020/04-2021/03