服部 明

Last Update: 2018/06/29 21:33:03

Print

Name(Kanji/Kana/Abecedarium Latinum)
服部 明/ハットリ アキラ/Hattori, Akira
Primary Affiliation(Org1/Job title)
Graduate Schools Pharmaceutical Sciences/Associate Professor
Faculty
Org1 Job title
薬学部
Academic Organizations You are Affiliated to in Japan
Organization name(Japanese) Organization name(English)
日本生化学会
日本癌学会
日本病態プロテアーゼ学会
日本癌分子標的学会
日本薬学会
Academic Degree
Field(Japanese) Field(English) University(Japanese) University(English) Method
修士(薬学) 岐阜薬科大学
博士(薬学) 岐阜薬科大学
Graduate School
University(Japanese) University(English) Faculty(Japanese) Faculty(English) Major(Japanese) Major(English) Degree
岐阜薬科大学 大学院薬学研究科博士課程分子生物学専攻 修了
岐阜薬科大学 大学院薬学研究科修士課程分子生物学専攻 修了
Undergraduate School / Major(s)
University(Japanese) University(English) Faculty(Japanese) Faculty(English) Major(s)(Japanese) Major(s)(English) Degree
岐阜薬科大学 製造薬学科 卒業
High School
Highschool Kana
愛知県立岡崎北高校 おかざききたこうこう
Work Experience
Period Organization(Japanese) Organization(English) Job title(Japanese) Job title(English)
-
researchmap URL
https://researchmap.jp/7000008644
Research Topics
(Japanese)
タンパク質分解反応の細胞生物学・化学生物学
Overview of the research
(Japanese)
M1アミノペプチダーゼや脱ユビキチン化酵素などのタンパク質分解酵素の生理的・病理的機能の解析を生化学や細胞生物的手法を用いて明らかにする。解析を通じて、病態と深く関わる分子の同定やそれを標的とした新しい疾患治療法の確立を目指す。
Fields of research (key words)
Key words(Japanese) Key words(English)
アミノペプチダーゼ
脂肪細胞由来ロイシンアミノペプチダーゼ
胎盤性ロイシンアミノペプチダーゼ
小胞体アミノペプチダーゼ
オキシトシナーゼサブファミリー
白血球由来アルギニンアミノペプチダーゼ
X線結晶構造解析
小胞体貯留機構
MHCクラスI抗原ペプチド
インターフェロン-γ
阻害剤
脱ユビキチン化酵素
基質特異性
抗原ペプチド
ユビキチン
activity-based probe
一塩基多型
プロテアーゼ
血圧調節
プロモーター領域
活性制御
Laeverin
プロテオミクス解析
ウィルス感染
抗原提示
遺伝子発現調節
強直性脊椎炎
ユビキチン様ドメイン
酸化ストレス
HLA
システインプロテアーゼ

  • <<
  • >>
Published Papers
Author Author(Japanese) Author(English) Title Title(Japanese) Title(English) Bibliography Bibliography(Japanese) Bibliography(English) Publication date Refereed paper Language Publishing type Disclose
Hisanori Matsumoto, Hisanori Matsumoto, Yukiyasu Sato, Yukiyasu Sato, Akihito Horie, Koh Suginami, Hirohiko Tani, Akira Hattori, Yoshihiko Araki, Kyosuke Kagami, Ikuo Konishi, Ikuo Konishi, Hiroshi Fujiwara, Hiroshi Fujiwara Hisanori Matsumoto, Hisanori Matsumoto, Yukiyasu Sato, Yukiyasu Sato, Akihito Horie, Koh Suginami, Hirohiko Tani, Akira Hattori, Yoshihiko Araki, Kyosuke Kagami, Ikuo Konishi, Ikuo Konishi, Hiroshi Fujiwara, Hiroshi Fujiwara Hisanori Matsumoto, Hisanori Matsumoto, Yukiyasu Sato, Yukiyasu Sato, Akihito Horie, Koh Suginami, Hirohiko Tani, Akira Hattori, Yoshihiko Araki, Kyosuke Kagami, Ikuo Konishi, Ikuo Konishi, Hiroshi Fujiwara, Hiroshi Fujiwara CD9 suppresses human extravillous trophoblast invasion CD9 suppresses human extravillous trophoblast invasion CD9 suppresses human extravillous trophoblast invasion Placenta, 47, 105-112 Placenta, 47, 105-112 Placenta, 47, 105-112 2016/11/01 Disclose to all
Atsushi Ohnishi, Jobu Watanabe, Yuko Ogawa, Yoshikuni Goto, Akira Hattori, Masafumi Tsujimoto Atsushi Ohnishi, Jobu Watanabe, Yuko Ogawa, Yoshikuni Goto, Akira Hattori, Masafumi Tsujimoto Atsushi Ohnishi, Jobu Watanabe, Yuko Ogawa, Yoshikuni Goto, Akira Hattori, Masafumi Tsujimoto Involvement of Phenylalanine 297 in the Construction of the Substrate Pocket of Human Aminopeptidase B Involvement of Phenylalanine 297 in the Construction of the Substrate Pocket of Human Aminopeptidase B Involvement of Phenylalanine 297 in the Construction of the Substrate Pocket of Human Aminopeptidase B Biochemistry, 54, 6062-6070 Biochemistry, 54, 6062-6070 Biochemistry, 54, 6062-6070 2015/10/06 Disclose to all
Piao J, Tashiro A, Nishikawa M, Aoki Y, Moriyoshi E, Hattori A, Kakeya H Piao J, Tashiro A, Nishikawa M, Aoki Y, Moriyoshi E, Hattori A, Kakeya H Piao J, Tashiro A, Nishikawa M, Aoki Y, Moriyoshi E, Hattori A, Kakeya H Expression, purification and enzymatic characterization of a recombinant human ubiquitin-specific protease 47. Expression, purification and enzymatic characterization of a recombinant human ubiquitin-specific protease 47. Expression, purification and enzymatic characterization of a recombinant human ubiquitin-specific protease 47. Journal of biochemistry, 158, 6, 477-484 Journal of biochemistry, 158, 6, 477-484 Journal of biochemistry, 158, 6, 477-484 2015/06 Refereed Disclose to all
Goto Y, Ogawa K, Nakamura TJ, Hattori A, Tsujimoto M Goto Y, Ogawa K, Nakamura TJ, Hattori A, Tsujimoto M Goto Y, Ogawa K, Nakamura TJ, Hattori A, Tsujimoto M Substrate-dependent nitric oxide synthesis by secreted endoplasmic reticulum aminopeptidase 1 in macrophages. Substrate-dependent nitric oxide synthesis by secreted endoplasmic reticulum aminopeptidase 1 in macrophages. Substrate-dependent nitric oxide synthesis by secreted endoplasmic reticulum aminopeptidase 1 in macrophages. Journal of biochemistry, 157, 6, 439-449 Journal of biochemistry, 157, 6, 439-449 Journal of biochemistry, 157, 6, 439-449 2015/06 Refereed Disclose to all
Yasuda Y, Arakawa T, Nawata Y, Shimada S, Oishi S, Fujii N, Nishimura S, Hattori A, Kakeya H Yasuda Y, Arakawa T, Nawata Y, Shimada S, Oishi S, Fujii N, Nishimura S, Hattori A, Kakeya H Yasuda Y, Arakawa T, Nawata Y, Shimada S, Oishi S, Fujii N, Nishimura S, Hattori A, Kakeya H Design, synthesis, and structure-activity relationships of 1-ethylpyrazole-3-carboxamide compounds as novel hypoxia-inducible factor (HIF)-1 inhibitors. Design, synthesis, and structure-activity relationships of 1-ethylpyrazole-3-carboxamide compounds as novel hypoxia-inducible factor (HIF)-1 inhibitors. Design, synthesis, and structure-activity relationships of 1-ethylpyrazole-3-carboxamide compounds as novel hypoxia-inducible factor (HIF)-1 inhibitors. Bioorganic & medicinal chemistry, 23, 8, 1776-1787 Bioorganic & medicinal chemistry, 23, 8, 1776-1787 Bioorganic & medicinal chemistry, 23, 8, 1776-1787 2015/04 Refereed Disclose to all
Tsunematsu Y, Nishimura S, Hattori A, Oishi S, Fujii N, Kakeya H Tsunematsu Y, Nishimura S, Hattori A, Oishi S, Fujii N, Kakeya H Tsunematsu Y, Nishimura S, Hattori A, Oishi S, Fujii N, Kakeya H Isolation, structure elucidation, and total synthesis of tryptopeptins A and B, new TGF-β signaling modulators from Streptomyces sp. Isolation, structure elucidation, and total synthesis of tryptopeptins A and B, new TGF-β signaling modulators from Streptomyces sp. Isolation, structure elucidation, and total synthesis of tryptopeptins A and B, new TGF-β signaling modulators from Streptomyces sp. Organic letters, 17, 2, 258-261 Organic letters, 17, 2, 258-261 Organic letters, 17, 2, 258-261 2015/01 Refereed Disclose to all
Kishimoto S, Nishimura S, Hattori A, Tsujimoto M, Hatano M, Igarashi M, Kakeya H Kishimoto S, Nishimura S, Hattori A, Tsujimoto M, Hatano M, Igarashi M, Kakeya H Kishimoto S, Nishimura S, Hattori A, Tsujimoto M, Hatano M, Igarashi M, Kakeya H Chlorocatechelins A and B from Streptomyces sp.: new siderophores containing chlorinated catecholate groups and an acylguanidine structure. Chlorocatechelins A and B from Streptomyces sp.: new siderophores containing chlorinated catecholate groups and an acylguanidine structure. Chlorocatechelins A and B from Streptomyces sp.: new siderophores containing chlorinated catecholate groups and an acylguanidine structure. Organic letters, 16, 23, 6108-6111 Organic letters, 16, 23, 6108-6111 Organic letters, 16, 23, 6108-6111 2014/12 Refereed Disclose to all
Yoshimura A, Kishimoto S, Nishimura S, Otsuka S, Sakai Y, Hattori A, Kakeya H Yoshimura A, Kishimoto S, Nishimura S, Otsuka S, Sakai Y, Hattori A, Kakeya H Yoshimura A, Kishimoto S, Nishimura S, Otsuka S, Sakai Y, Hattori A, Kakeya H Prediction and determination of the stereochemistry of the 1,3,5-trimethyl-substituted alkyl chain in verucopeptin, a microbial metabolite. Prediction and determination of the stereochemistry of the 1,3,5-trimethyl-substituted alkyl chain in verucopeptin, a microbial metabolite. Prediction and determination of the stereochemistry of the 1,3,5-trimethyl-substituted alkyl chain in verucopeptin, a microbial metabolite. The Journal of organic chemistry, 79, 15, 6858-6867 The Journal of organic chemistry, 79, 15, 6858-6867 The Journal of organic chemistry, 79, 15, 6858-6867 2014/08 Refereed Disclose to all
Ogawa Y, Ohnishi A, Goto Y, Sakuma Y, Watanabe J, Hattori A, Tsujimoto M Ogawa Y, Ohnishi A, Goto Y, Sakuma Y, Watanabe J, Hattori A, Tsujimoto M Ogawa Y, Ohnishi A, Goto Y, Sakuma Y, Watanabe J, Hattori A, Tsujimoto M Role of glutamine-169 in the substrate recognition of human aminopeptidase B. Role of glutamine-169 in the substrate recognition of human aminopeptidase B. Role of glutamine-169 in the substrate recognition of human aminopeptidase B. Biochimica et biophysica acta, 1840, 6, 1872-1881 Biochimica et biophysica acta, 1840, 6, 1872-1881 Biochimica et biophysica acta, 1840, 6, 1872-1881 2014/06 Refereed Disclose to all
Goto Y, Ogawa K, Nakamura TJ, Hattori A, Tsujimoto M Goto Y, Ogawa K, Nakamura TJ, Hattori A, Tsujimoto M Goto Y, Ogawa K, Nakamura TJ, Hattori A, Tsujimoto M TLR-mediated secretion of endoplasmic reticulum aminopeptidase 1 from macrophages. TLR-mediated secretion of endoplasmic reticulum aminopeptidase 1 from macrophages. TLR-mediated secretion of endoplasmic reticulum aminopeptidase 1 from macrophages. Journal of immunology (Baltimore, Md. : 1950), 192, 9, 4443-4452 Journal of immunology (Baltimore, Md. : 1950), 192, 9, 4443-4452 Journal of immunology (Baltimore, Md. : 1950), 192, 9, 4443-4452 2014/05 Refereed Disclose to all
Sugiyama R, Nishimura S, Matsumori N, Tsunematsu Y, Hattori A, Kakeya H Sugiyama R, Nishimura S, Matsumori N, Tsunematsu Y, Hattori A, Kakeya H Sugiyama R, Nishimura S, Matsumori N, Tsunematsu Y, Hattori A, Kakeya H Structure and biological activity of 8-deoxyheronamide C from a marine-derived Streptomyces sp.: heronamides target saturated hydrocarbon chains in lipid membranes. Structure and biological activity of 8-deoxyheronamide C from a marine-derived Streptomyces sp.: heronamides target saturated hydrocarbon chains in lipid membranes. Structure and biological activity of 8-deoxyheronamide C from a marine-derived Streptomyces sp.: heronamides target saturated hydrocarbon chains in lipid membranes. Journal of the American Chemical Society, 136, 14, 5209-5212 Journal of the American Chemical Society, 136, 14, 5209-5212 Journal of the American Chemical Society, 136, 14, 5209-5212 2014/04 Refereed Disclose to all
S. Otsuki; S. Nishimura; H. Takabatake; K. Nakajima; Y. Takasu; T. Yagura; Y. Sakai; A. Hattori; H. Kakeya S. Otsuki; S. Nishimura; H. Takabatake; K. Nakajima; Y. Takasu; T. Yagura; Y. Sakai; A. Hattori; H. Kakeya S. Otsuki; S. Nishimura; H. Takabatake; K. Nakajima; Y. Takasu; T. Yagura; Y. Sakai; A. Hattori; H. Kakeya Chemical tagging of a drug target using 5-sulfonyl tetrazole Chemical tagging of a drug target using 5-sulfonyl tetrazole Chemical tagging of a drug target using 5-sulfonyl tetrazole Bioorganic and Medicinal Chemistry Letters, 23, 6, 1608-1611 Bioorganic and Medicinal Chemistry Letters, 23, 6, 1608-1611 Bioorganic and Medicinal Chemistry Letters, 23, 6, 1608-1611 2013 Refereed English Disclose to all
Y. Nagamoto; A. Hattori; H. Kakeya; Y. Takemoto; K. Takasu Y. Nagamoto; A. Hattori; H. Kakeya; Y. Takemoto; K. Takasu Y. Nagamoto; A. Hattori; H. Kakeya; Y. Takemoto; K. Takasu PH-sensitive DNA cleaving agents: In situ activation by ring contraction of benzo-fused cyclobutanols PH-sensitive DNA cleaving agents: In situ activation by ring contraction of benzo-fused cyclobutanols PH-sensitive DNA cleaving agents: In situ activation by ring contraction of benzo-fused cyclobutanols Chemical Communications, 49, 26, 2622-2624 Chemical Communications, 49, 26, 2622-2624 Chemical Communications, 49, 26, 2622-2624 2013 Refereed English Disclose to all
A. Hattori; M. Tsujimoto A. Hattori; M. Tsujimoto A. Hattori; M. Tsujimoto Endoplasmic reticulum aminopeptidases: Biochemistry, physiology and pathology Endoplasmic reticulum aminopeptidases: Biochemistry, physiology and pathology Endoplasmic reticulum aminopeptidases: Biochemistry, physiology and pathology Journal of Biochemistry, 154, 3, 219-228 Journal of Biochemistry, 154, 3, 219-228 Journal of Biochemistry, 154, 3, 219-228 2013 Refereed English Disclose to all
A. Hattori; M. Maruyama; H. Fujiwara; M. Tsujimoto A. Hattori; M. Maruyama; H. Fujiwara; M. Tsujimoto A. Hattori; M. Maruyama; H. Fujiwara; M. Tsujimoto Aminopeptidase Q/Laeverin Aminopeptidase Q/Laeverin Aminopeptidase Q/Laeverin Handbook of Proteolytic Enzymes, 1, 442-444 Handbook of Proteolytic Enzymes, 1, 442-444 Handbook of Proteolytic Enzymes, 1, 442-444 2013 Refereed English Disclose to all
Y. Ohno; A. Hattori; T. Yoshiki; H. Kakeya Y. Ohno; A. Hattori; T. Yoshiki; H. Kakeya Y. Ohno; A. Hattori; T. Yoshiki; H. Kakeya Association of epigenetic alterations in the human C7orf24 gene with the aberrant gene expression in malignant cells Association of epigenetic alterations in the human C7orf24 gene with the aberrant gene expression in malignant cells Association of epigenetic alterations in the human C7orf24 gene with the aberrant gene expression in malignant cells Journal of Biochemistry, 154, 4, 355-362 Journal of Biochemistry, 154, 4, 355-362 Journal of Biochemistry, 154, 4, 355-362 2013 Refereed English Disclose to all
S. Mizutani; T. Tsunemi; E. Mizutani; A. Hattori; M. Tsujimoto; H. Kobayashi S. Mizutani; T. Tsunemi; E. Mizutani; A. Hattori; M. Tsujimoto; H. Kobayashi S. Mizutani; T. Tsunemi; E. Mizutani; A. Hattori; M. Tsujimoto; H. Kobayashi New insights into the role of aminopeptidases in the treatment for both preeclampsia and preterm labor New insights into the role of aminopeptidases in the treatment for both preeclampsia and preterm labor New insights into the role of aminopeptidases in the treatment for both preeclampsia and preterm labor Expert Opinion on Investigational Drugs, 22, 11, 1425-1436 Expert Opinion on Investigational Drugs, 22, 11, 1425-1436 Expert Opinion on Investigational Drugs, 22, 11, 1425-1436 2013 Refereed English Disclose to all
A. Horie; H. Fujiwara; Y. Sato; K. Suginami; H. Matsumoto; M. Maruyama; I. Konishi; A. Hattori A. Horie; H. Fujiwara; Y. Sato; K. Suginami; H. Matsumoto; M. Maruyama; I. Konishi; A. Hattori A. Horie; H. Fujiwara; Y. Sato; K. Suginami; H. Matsumoto; M. Maruyama; I. Konishi; A. Hattori Laeverin/aminopeptidase Q induces trophoblast invasion during human early placentation Laeverin/aminopeptidase Q induces trophoblast invasion during human early placentation Laeverin/aminopeptidase Q induces trophoblast invasion during human early placentation Human Reproduction, 27, 5, 1267-1276 Human Reproduction, 27, 5, 1267-1276 Human Reproduction, 27, 5, 1267-1276 2012/05 Refereed English Disclose to all
A. Hattori; Y. Goto; M. Tsujimoto A. Hattori; Y. Goto; M. Tsujimoto A. Hattori; Y. Goto; M. Tsujimoto Exon 10 coding sequence is important for endoplasmic reticulum retention of endoplasmic reticulum aminopeptidase 1 Exon 10 coding sequence is important for endoplasmic reticulum retention of endoplasmic reticulum aminopeptidase 1 Exon 10 coding sequence is important for endoplasmic reticulum retention of endoplasmic reticulum aminopeptidase 1 Biological and Pharmaceutical Bulletin, 35, 4, 601-605 Biological and Pharmaceutical Bulletin, 35, 4, 601-605 Biological and Pharmaceutical Bulletin, 35, 4, 601-605 2012 Refereed English Disclose to all
S. Kishimoto; Y. Tsunematsu; S. Nishimura; Y. Hayashi; A. Hattori; H. Kakeya S. Kishimoto; Y. Tsunematsu; S. Nishimura; Y. Hayashi; A. Hattori; H. Kakeya S. Kishimoto; Y. Tsunematsu; S. Nishimura; Y. Hayashi; A. Hattori; H. Kakeya Tumescenamide C, an antimicrobial cyclic lipodepsipeptide from Streptomyces sp. Tumescenamide C, an antimicrobial cyclic lipodepsipeptide from Streptomyces sp. Tumescenamide C, an antimicrobial cyclic lipodepsipeptide from Streptomyces sp. Tetrahedron, 68, 27-28, 5572-5578 Tetrahedron, 68, 27-28, 5572-5578 Tetrahedron, 68, 27-28, 5572-5578 2012 Refereed English Disclose to all
Y. Ohno; A. Hattori; H. Kakeya Y. Ohno; A. Hattori; H. Kakeya Y. Ohno; A. Hattori; H. Kakeya [C7orf24/gamma-glutamyl cyclotransferase as a molecular target for cancer chemotherapy]. [C7orf24/gamma-glutamyl cyclotransferase as a molecular target for cancer chemotherapy]. [C7orf24/gamma-glutamyl cyclotransferase as a molecular target for cancer chemotherapy]. Nihon rinsho. Japanese journal of clinical medicine, 70 Suppl 8, 723-727 Nihon rinsho. Japanese journal of clinical medicine, 70 Suppl 8, 723-727 Nihon rinsho. Japanese journal of clinical medicine, 70 Suppl 8, 723-727 2012 Refereed English Disclose to all
Y. Ohno; A. Hattori; M. Ueda; S. Kageyama; T. Yoshiki; H. Kakeya Y. Ohno; A. Hattori; M. Ueda; S. Kageyama; T. Yoshiki; H. Kakeya Y. Ohno; A. Hattori; M. Ueda; S. Kageyama; T. Yoshiki; H. Kakeya Multiple NF-Y-binding CCAAT boxes are essential for transcriptional regulation of the human C7orf24 gene, a novel tumor-associated gene Multiple NF-Y-binding CCAAT boxes are essential for transcriptional regulation of the human C7orf24 gene, a novel tumor-associated gene Multiple NF-Y-binding CCAAT boxes are essential for transcriptional regulation of the human C7orf24 gene, a novel tumor-associated gene FEBS Journal, 278, 21, 4088-4099 FEBS Journal, 278, 21, 4088-4099 FEBS Journal, 278, 21, 4088-4099 2011/11 Refereed English Disclose to all
Y. Goto; R. Yoshioka; N. Arisaka; A. Hattori; M. Tsujimoto Y. Goto; R. Yoshioka; N. Arisaka; A. Hattori; M. Tsujimoto Y. Goto; R. Yoshioka; N. Arisaka; A. Hattori; M. Tsujimoto Involvement of glutamine-238 in the substrate specificity of human laeverin/aminopeptidase Q Involvement of glutamine-238 in the substrate specificity of human laeverin/aminopeptidase Q Involvement of glutamine-238 in the substrate specificity of human laeverin/aminopeptidase Q Biological and Pharmaceutical Bulletin, 34, 1, 24-27 Biological and Pharmaceutical Bulletin, 34, 1, 24-27 Biological and Pharmaceutical Bulletin, 34, 1, 24-27 2011 Refereed English Disclose to all
I. Evnouchidou; R.P. Kamal; S.S. Seregin; Y. Goto; M. Tsujimoto; A. Hattori; P.V. Voulgari; A.A. Drosos; A. Amalfitano; I.A. York; E. Stratikos I. Evnouchidou; R.P. Kamal; S.S. Seregin; Y. Goto; M. Tsujimoto; A. Hattori; P.V. Voulgari; A.A. Drosos; A. Amalfitano; I.A. York; E. Stratikos I. Evnouchidou; R.P. Kamal; S.S. Seregin; Y. Goto; M. Tsujimoto; A. Hattori; P.V. Voulgari; A.A. Drosos; A. Amalfitano; I.A. York; E. Stratikos Cutting edge: Coding single nucleotide polymorphisms of endoplasmic reticulum aminopeptidase 1 can affect antigenic peptide generation in vitro by influencing basic enzymatic properties of the enzyme Cutting edge: Coding single nucleotide polymorphisms of endoplasmic reticulum aminopeptidase 1 can affect antigenic peptide generation in vitro by influencing basic enzymatic properties of the enzyme Cutting edge: Coding single nucleotide polymorphisms of endoplasmic reticulum aminopeptidase 1 can affect antigenic peptide generation in vitro by influencing basic enzymatic properties of the enzyme Journal of Immunology, 186, 4, 1909-1913 Journal of Immunology, 186, 4, 1909-1913 Journal of Immunology, 186, 4, 1909-1913 2011 Refereed English Disclose to all
E. Zervoudi; A. Papakyriakou; D. Georgiadou; I. Evnouchidou; A. Gajda; M. Poreba; G.S. Salvesen; M. Drag; A. Hattori; L. Swevers; D. Vourloumis; E. Stratikos E. Zervoudi; A. Papakyriakou; D. Georgiadou; I. Evnouchidou; A. Gajda; M. Poreba; G.S. Salvesen; M. Drag; A. Hattori; L. Swevers; D. Vourloumis; E. Stratikos E. Zervoudi; A. Papakyriakou; D. Georgiadou; I. Evnouchidou; A. Gajda; M. Poreba; G.S. Salvesen; M. Drag; A. Hattori; L. Swevers; D. Vourloumis; E. Stratikos Probing the S1 specificity pocket of the aminopeptidases that generate antigenic peptides Probing the S1 specificity pocket of the aminopeptidases that generate antigenic peptides Probing the S1 specificity pocket of the aminopeptidases that generate antigenic peptides Biochemical Journal, 435, 2, 411-420 Biochemical Journal, 435, 2, 411-420 Biochemical Journal, 435, 2, 411-420 2011 Refereed English Disclose to all
Y. Goto; K. Ogawa; A. Hattori; M. Tsujimoto Y. Goto; K. Ogawa; A. Hattori; M. Tsujimoto Y. Goto; K. Ogawa; A. Hattori; M. Tsujimoto Secretion of endoplasmic reticulum aminopeptidase 1 is involved in the activation of macrophages induced by lipopolysaccharide and interferon-γ Secretion of endoplasmic reticulum aminopeptidase 1 is involved in the activation of macrophages induced by lipopolysaccharide and interferon-γ Secretion of endoplasmic reticulum aminopeptidase 1 is involved in the activation of macrophages induced by lipopolysaccharide and interferon-γ Journal of Biological Chemistry, 286, 24, 21906-21914 Journal of Biological Chemistry, 286, 24, 21906-21914 Journal of Biological Chemistry, 286, 24, 21906-21914 2011 Refereed English Disclose to all
R. Waditee-Sirisattha; J. Shibato; R. Rakwal; S. Sirisattha; A. Hattori; T. Nakano; T. Takabe; M. Tsujimoto R. Waditee-Sirisattha; J. Shibato; R. Rakwal; S. Sirisattha; A. Hattori; T. Nakano; T. Takabe; M. Tsujimoto R. Waditee-Sirisattha; J. Shibato; R. Rakwal; S. Sirisattha; A. Hattori; T. Nakano; T. Takabe; M. Tsujimoto The Arabidopsis aminopeptidase LAP2 regulates plant growth, leaf longevity and stress response The Arabidopsis aminopeptidase LAP2 regulates plant growth, leaf longevity and stress response The Arabidopsis aminopeptidase LAP2 regulates plant growth, leaf longevity and stress response New Phytologist, 191, 4, 958-969 New Phytologist, 191, 4, 958-969 New Phytologist, 191, 4, 958-969 2011 Refereed English Disclose to all
R. Waditee-Sirisattha; A. Hattori; J. Shibato; R. Rakwal; S. Sirisattha; T. Takabe; M. Tsujimoto R. Waditee-Sirisattha; A. Hattori; J. Shibato; R. Rakwal; S. Sirisattha; T. Takabe; M. Tsujimoto R. Waditee-Sirisattha; A. Hattori; J. Shibato; R. Rakwal; S. Sirisattha; T. Takabe; M. Tsujimoto Role of the arabidopsis leucine aminopeptidase 2 Role of the arabidopsis leucine aminopeptidase 2 Role of the arabidopsis leucine aminopeptidase 2 Plant Signaling and Behavior, 6, 10, 1581-1583 Plant Signaling and Behavior, 6, 10, 1581-1583 Plant Signaling and Behavior, 6, 10, 1581-1583 2011 Refereed English Disclose to all
M. Ishii; K. Naruse; A. Hattori; M. Tsujimoto; S. Ishiura; Y. Numaguchi; T. Murohara; H. Kobayashi; S. Mizutani M. Ishii; K. Naruse; A. Hattori; M. Tsujimoto; S. Ishiura; Y. Numaguchi; T. Murohara; H. Kobayashi; S. Mizutani M. Ishii; K. Naruse; A. Hattori; M. Tsujimoto; S. Ishiura; Y. Numaguchi; T. Murohara; H. Kobayashi; S. Mizutani Oxytocin hypersensitivity in pregnant P-LAP deficient mice Oxytocin hypersensitivity in pregnant P-LAP deficient mice Oxytocin hypersensitivity in pregnant P-LAP deficient mice Life Sciences, 84, 19-20, 668-672 Life Sciences, 84, 19-20, 668-672 Life Sciences, 84, 19-20, 668-672 2009 Refereed English Disclose to all
M. Ishii; A. Hattori; Y. Numaguchi; X. Ma; T. Nagasaka; M. Tsujimoto; T. Murohara; H. Kobayashi; S. Mizutani M. Ishii; A. Hattori; Y. Numaguchi; X. Ma; T. Nagasaka; M. Tsujimoto; T. Murohara; H. Kobayashi; S. Mizutani M. Ishii; A. Hattori; Y. Numaguchi; X. Ma; T. Nagasaka; M. Tsujimoto; T. Murohara; H. Kobayashi; S. Mizutani The effect of recombinant aminopeptidase A (APA) on hypertension in pregnant spontaneously hypertensive rats (SHRs) The effect of recombinant aminopeptidase A (APA) on hypertension in pregnant spontaneously hypertensive rats (SHRs) The effect of recombinant aminopeptidase A (APA) on hypertension in pregnant spontaneously hypertensive rats (SHRs) Early Human Development, 85, 9, 589-594 Early Human Development, 85, 9, 589-594 Early Human Development, 85, 9, 589-594 2009 Refereed English Disclose to all
M. Maruyama; N. Arisaka; Y. Goto; Y. Ohsawa; H. Inoue; H. Fujiwara; A. Hattori; M. Tsujimoto M. Maruyama; N. Arisaka; Y. Goto; Y. Ohsawa; H. Inoue; H. Fujiwara; A. Hattori; M. Tsujimoto M. Maruyama; N. Arisaka; Y. Goto; Y. Ohsawa; H. Inoue; H. Fujiwara; A. Hattori; M. Tsujimoto Histidine 379 of Human laeverin/aminopeptidase Q, a nonconserved residue within the exopeptidase motif, defines its distinctive enzymatic properties Histidine 379 of Human laeverin/aminopeptidase Q, a nonconserved residue within the exopeptidase motif, defines its distinctive enzymatic properties Histidine 379 of Human laeverin/aminopeptidase Q, a nonconserved residue within the exopeptidase motif, defines its distinctive enzymatic properties Journal of Biological Chemistry, 284, 50, 34692-34702 Journal of Biological Chemistry, 284, 50, 34692-34702 Journal of Biological Chemistry, 284, 50, 34692-34702 2009 Refereed English Disclose to all
S. Mizutani; K. Naruse; A. Hattori; M. Tsujimoto; H. Kobayashi S. Mizutani; K. Naruse; A. Hattori; M. Tsujimoto; H. Kobayashi S. Mizutani; K. Naruse; A. Hattori; M. Tsujimoto; H. Kobayashi Physiological and pathophysiological roles of placental aminopeptidase in maternal sera: Possible relation to preeclampsia and preterm delivery Physiological and pathophysiological roles of placental aminopeptidase in maternal sera: Possible relation to preeclampsia and preterm delivery Physiological and pathophysiological roles of placental aminopeptidase in maternal sera: Possible relation to preeclampsia and preterm delivery Expert Opinion on Medical Diagnostics, 3, 5, 479-491 Expert Opinion on Medical Diagnostics, 3, 5, 479-491 Expert Opinion on Medical Diagnostics, 3, 5, 479-491 2009 Refereed English Disclose to all
M. Tsujimoto; Y. Goto; M. Maruyama; A. Hattori M. Tsujimoto; Y. Goto; M. Maruyama; A. Hattori M. Tsujimoto; Y. Goto; M. Maruyama; A. Hattori Biochemical and enzymatic properties of the M1 family of aminopeptidases involved in the regulation of blood pressure Biochemical and enzymatic properties of the M1 family of aminopeptidases involved in the regulation of blood pressure Biochemical and enzymatic properties of the M1 family of aminopeptidases involved in the regulation of blood pressure Heart Failure Reviews, 13, 3, 285-291 Heart Failure Reviews, 13, 3, 285-291 Heart Failure Reviews, 13, 3, 285-291 2008 Refereed English Disclose to all
S. Mizutani; M. Ishii; A. Hattori; S. Nomura; Y. Numaguchi; M. Tsujimoto; H. Kobayshi; T. Murohara; J.W. Wright S. Mizutani; M. Ishii; A. Hattori; S. Nomura; Y. Numaguchi; M. Tsujimoto; H. Kobayshi; T. Murohara; J.W. Wright S. Mizutani; M. Ishii; A. Hattori; S. Nomura; Y. Numaguchi; M. Tsujimoto; H. Kobayshi; T. Murohara; J.W. Wright New insights into the importance of aminopeptidase A in hypertension New insights into the importance of aminopeptidase A in hypertension New insights into the importance of aminopeptidase A in hypertension Heart Failure Reviews, 13, 3, 273-284 Heart Failure Reviews, 13, 3, 273-284 Heart Failure Reviews, 13, 3, 273-284 2008 Refereed English Disclose to all
Y. Goto; H. Tanji; A. Hattori; M. Tsujimoto Y. Goto; H. Tanji; A. Hattori; M. Tsujimoto Y. Goto; H. Tanji; A. Hattori; M. Tsujimoto Glutamine-181 is crucial in the enzymatic activity and substrate specificity of human endoplasmic-reticulum aminopeptidase-1 Glutamine-181 is crucial in the enzymatic activity and substrate specificity of human endoplasmic-reticulum aminopeptidase-1 Glutamine-181 is crucial in the enzymatic activity and substrate specificity of human endoplasmic-reticulum aminopeptidase-1 Biochemical Journal, 416, 1, 109-116 Biochemical Journal, 416, 1, 109-116 Biochemical Journal, 416, 1, 109-116 2008 Refereed English Disclose to all
M. Ishii; A. Hattori; Y. Numaguchi; M. Tsujimoto; S. Ishiura; H. Kobayashi; T. Murohara; J.-W. Wright; S. Mizutani M. Ishii; A. Hattori; Y. Numaguchi; M. Tsujimoto; S. Ishiura; H. Kobayashi; T. Murohara; J.-W. Wright; S. Mizutani M. Ishii; A. Hattori; Y. Numaguchi; M. Tsujimoto; S. Ishiura; H. Kobayashi; T. Murohara; J.-W. Wright; S. Mizutani The effect of recombinant aminopeptidase A on hypertension in spontaneously hypertensive rats: Its effect in comparison with candesartan The effect of recombinant aminopeptidase A on hypertension in spontaneously hypertensive rats: Its effect in comparison with candesartan The effect of recombinant aminopeptidase A on hypertension in spontaneously hypertensive rats: Its effect in comparison with candesartan Hormone and Metabolic Research, 40, 12, 887-891 Hormone and Metabolic Research, 40, 12, 887-891 Hormone and Metabolic Research, 40, 12, 887-891 2008 Refereed English Disclose to all
M. Maruyama; A. Hattori; Y. Goto; M. Ueda; M. Maeda; H. Fujiwara; M. Tsujimoto M. Maruyama; A. Hattori; Y. Goto; M. Ueda; M. Maeda; H. Fujiwara; M. Tsujimoto M. Maruyama; A. Hattori; Y. Goto; M. Ueda; M. Maeda; H. Fujiwara; M. Tsujimoto Laeverin/aminopeptidase Q, a novel bestatin-sensitive leucine aminopeptidase belonging to the M1 family of aminopeptidases Laeverin/aminopeptidase Q, a novel bestatin-sensitive leucine aminopeptidase belonging to the M1 family of aminopeptidases Laeverin/aminopeptidase Q, a novel bestatin-sensitive leucine aminopeptidase belonging to the M1 family of aminopeptidases Journal of Biological Chemistry, 282, 28, 20088-20096 Journal of Biological Chemistry, 282, 28, 20088-20096 Journal of Biological Chemistry, 282, 28, 20088-20096 2007/07/13 Refereed English Disclose to all
S. Mizutani; K. Shibata; F. Kikkawa; A. Hattori; M. Tsujimoto; M. Ishii; H. Kobayashi S. Mizutani; K. Shibata; F. Kikkawa; A. Hattori; M. Tsujimoto; M. Ishii; H. Kobayashi S. Mizutani; K. Shibata; F. Kikkawa; A. Hattori; M. Tsujimoto; M. Ishii; H. Kobayashi Essential role of placental leucine aminopeptidase in gynecologic malignancy Essential role of placental leucine aminopeptidase in gynecologic malignancy Essential role of placental leucine aminopeptidase in gynecologic malignancy Expert Opinion on Therapeutic Targets, 11, 4, 453-461 Expert Opinion on Therapeutic Targets, 11, 4, 453-461 Expert Opinion on Therapeutic Targets, 11, 4, 453-461 2007 Refereed English Disclose to all
Y. Goto; A. Hattori; S. Mizutani; M. Tsujimoto Y. Goto; A. Hattori; S. Mizutani; M. Tsujimoto Y. Goto; A. Hattori; S. Mizutani; M. Tsujimoto Asparatic acid 221 is critical in the calcium-induced modulation of the enzymatic activity of human aminopeptidase A Asparatic acid 221 is critical in the calcium-induced modulation of the enzymatic activity of human aminopeptidase A Asparatic acid 221 is critical in the calcium-induced modulation of the enzymatic activity of human aminopeptidase A Journal of Biological Chemistry, 282, 51, 37074-37081 Journal of Biological Chemistry, 282, 51, 37074-37081 Journal of Biological Chemistry, 282, 51, 37074-37081 2007 Refereed English Disclose to all
Y. Goto; A. Hattori; Y. Ishii; M. Tsujimoto Y. Goto; A. Hattori; Y. Ishii; M. Tsujimoto Y. Goto; A. Hattori; Y. Ishii; M. Tsujimoto Reduced activity of the hypertension-associated Lys528Arg mutant of human adipocyte-derived leucine aminopeptidase (A-LAP)/ER-aminopeptidase-1 Reduced activity of the hypertension-associated Lys528Arg mutant of human adipocyte-derived leucine aminopeptidase (A-LAP)/ER-aminopeptidase-1 Reduced activity of the hypertension-associated Lys528Arg mutant of human adipocyte-derived leucine aminopeptidase (A-LAP)/ER-aminopeptidase-1 FEBS Letters, 580, 7, 1833-1838 FEBS Letters, 580, 7, 1833-1838 FEBS Letters, 580, 7, 1833-1838 2006 Refereed English Disclose to all
F. Shido; T. Ito; S. Nomura; E. Yamamoto; S. Sumigama; K. Ino; A. Itakura; A. Hattori; M. Tsujimoto; S. Mizutani; F. Kikkawa F. Shido; T. Ito; S. Nomura; E. Yamamoto; S. Sumigama; K. Ino; A. Itakura; A. Hattori; M. Tsujimoto; S. Mizutani; F. Kikkawa F. Shido; T. Ito; S. Nomura; E. Yamamoto; S. Sumigama; K. Ino; A. Itakura; A. Hattori; M. Tsujimoto; S. Mizutani; F. Kikkawa Endoplasmic reticulum aminopeptidase-1 mediates leukemia inhibitory factor-induced cell surface human leukocyte antigen-G expression in JEG-3 choriocarcinoma cells Endoplasmic reticulum aminopeptidase-1 mediates leukemia inhibitory factor-induced cell surface human leukocyte antigen-G expression in JEG-3 choriocarcinoma cells Endoplasmic reticulum aminopeptidase-1 mediates leukemia inhibitory factor-induced cell surface human leukocyte antigen-G expression in JEG-3 choriocarcinoma cells Endocrinology, 147, 4, 1780-1788 Endocrinology, 147, 4, 1780-1788 Endocrinology, 147, 4, 1780-1788 2006 Refereed English Disclose to all
Y. Goto; A. Hattori; Y. Ishii; S. Mizutani; M. Tsujimoto Y. Goto; A. Hattori; Y. Ishii; S. Mizutani; M. Tsujimoto Y. Goto; A. Hattori; Y. Ishii; S. Mizutani; M. Tsujimoto Enzymatic properties of human aminopeptidase A: Regulation of its enzymatic activity by calcium and angiotensin IV Enzymatic properties of human aminopeptidase A: Regulation of its enzymatic activity by calcium and angiotensin IV Enzymatic properties of human aminopeptidase A: Regulation of its enzymatic activity by calcium and angiotensin IV Journal of Biological Chemistry, 281, 33, 23503-23513 Journal of Biological Chemistry, 281, 33, 23503-23513 Journal of Biological Chemistry, 281, 33, 23503-23513 2006 Refereed English Disclose to all
D. Fruci; S. Ferracuti; M.Z. Limongi; V. Cunsolo; E. Giorda; R. Fraioli; L. Sibilio; O. Carroll; A. Hattori; P.M. Van Endert; P. Giacomini D. Fruci; S. Ferracuti; M.Z. Limongi; V. Cunsolo; E. Giorda; R. Fraioli; L. Sibilio; O. Carroll; A. Hattori; P.M. Van Endert; P. Giacomini D. Fruci; S. Ferracuti; M.Z. Limongi; V. Cunsolo; E. Giorda; R. Fraioli; L. Sibilio; O. Carroll; A. Hattori; P.M. Van Endert; P. Giacomini Expression of endoplasmic reticulum aminopeptidases in EBV-B cell lines from healthy donors and in leukemia/lymphoma, carcinoma, and melanoma cell lines Expression of endoplasmic reticulum aminopeptidases in EBV-B cell lines from healthy donors and in leukemia/lymphoma, carcinoma, and melanoma cell lines Expression of endoplasmic reticulum aminopeptidases in EBV-B cell lines from healthy donors and in leukemia/lymphoma, carcinoma, and melanoma cell lines Journal of Immunology, 176, 8, 4869-4879 Journal of Immunology, 176, 8, 4869-4879 Journal of Immunology, 176, 8, 4869-4879 2006 Refereed English Disclose to all
T. Tanioka; A. Hattori; S. Mizutani; M. Tsujimoto T. Tanioka; A. Hattori; S. Mizutani; M. Tsujimoto T. Tanioka; A. Hattori; S. Mizutani; M. Tsujimoto Regulation of the human leukocyte-derived arginine aminopeptidase/ endoplasmic reticulum-aminopeptidase 2 gene by interferon-γ Regulation of the human leukocyte-derived arginine aminopeptidase/ endoplasmic reticulum-aminopeptidase 2 gene by interferon-γ Regulation of the human leukocyte-derived arginine aminopeptidase/ endoplasmic reticulum-aminopeptidase 2 gene by interferon-γ FEBS Journal, 272, 4, 916-928 FEBS Journal, 272, 4, 916-928 FEBS Journal, 272, 4, 916-928 2005 Refereed English Disclose to all
M. Tsujimoto; A. Hattori M. Tsujimoto; A. Hattori M. Tsujimoto; A. Hattori The oxytocinase subfamily of M1 aminopeptidases The oxytocinase subfamily of M1 aminopeptidases The oxytocinase subfamily of M1 aminopeptidases Biochimica et Biophysica Acta - Proteins and Proteomics, 1751, 1, 9-18 Biochimica et Biophysica Acta - Proteins and Proteomics, 1751, 1, 9-18 Biochimica et Biophysica Acta - Proteins and Proteomics, 1751, 1, 9-18 2005 Refereed English Disclose to all
A. Hattori; M. Tsujimoto A. Hattori; M. Tsujimoto A. Hattori; M. Tsujimoto Processing of antigenic peptides by aminopeptidases Processing of antigenic peptides by aminopeptidases Processing of antigenic peptides by aminopeptidases Biological and Pharmaceutical Bulletin, 27, 6, 777-780 Biological and Pharmaceutical Bulletin, 27, 6, 777-780 Biological and Pharmaceutical Bulletin, 27, 6, 777-780 2004 Refereed English Disclose to all
D. Shibata; H. Ando; A. Iwase; T. Nagasaka; A. Hattori; M. Tsujimoto; S. Mizutani D. Shibata; H. Ando; A. Iwase; T. Nagasaka; A. Hattori; M. Tsujimoto; S. Mizutani D. Shibata; H. Ando; A. Iwase; T. Nagasaka; A. Hattori; M. Tsujimoto; S. Mizutani Distribution of adipocyte-derived leucine aminopeptidase (A-LAP)/ER-aminopeptidase (ERAP)-1 in human uterine endometrium Distribution of adipocyte-derived leucine aminopeptidase (A-LAP)/ER-aminopeptidase (ERAP)-1 in human uterine endometrium Distribution of adipocyte-derived leucine aminopeptidase (A-LAP)/ER-aminopeptidase (ERAP)-1 in human uterine endometrium Journal of Histochemistry and Cytochemistry, 52, 9, 1169-1175 Journal of Histochemistry and Cytochemistry, 52, 9, 1169-1175 Journal of Histochemistry and Cytochemistry, 52, 9, 1169-1175 2004 Refereed English Disclose to all
S. Masuda; A. Hattori; H. Matsumoto; S. Miyazawa; Y. Natori; S. Mizutani; M. Tsujimoto S. Masuda; A. Hattori; H. Matsumoto; S. Miyazawa; Y. Natori; S. Mizutani; M. Tsujimoto S. Masuda; A. Hattori; H. Matsumoto; S. Miyazawa; Y. Natori; S. Mizutani; M. Tsujimoto Involvement of the V<sub>2</sub> receptor in vasopressin-stimulated translocation of placental leucine aminopeptidase/oxytocinase in renal cells Involvement of the V<sub>2</sub> receptor in vasopressin-stimulated translocation of placental leucine aminopeptidase/oxytocinase in renal cells Involvement of the V<sub>2</sub> receptor in vasopressin-stimulated translocation of placental leucine aminopeptidase/oxytocinase in renal cells European Journal of Biochemistry, 270, 9, 1988-1994 European Journal of Biochemistry, 270, 9, 1988-1994 European Journal of Biochemistry, 270, 9, 1988-1994 2003 Refereed English Disclose to all
T. Tanioka; A. Hattori; S. Masuda; Y. Nomura; H. Nakayama; S. Mizutani; M. Tsujimoto T. Tanioka; A. Hattori; S. Masuda; Y. Nomura; H. Nakayama; S. Mizutani; M. Tsujimoto T. Tanioka; A. Hattori; S. Masuda; Y. Nomura; H. Nakayama; S. Mizutani; M. Tsujimoto Human leukocyte-derived arginine aminopeptidase. The third member of the oxytocinase subfamily of aminopeptidases Human leukocyte-derived arginine aminopeptidase. The third member of the oxytocinase subfamily of aminopeptidases Human leukocyte-derived arginine aminopeptidase. The third member of the oxytocinase subfamily of aminopeptidases Journal of Biological Chemistry, 278, 34, 32275-32283 Journal of Biological Chemistry, 278, 34, 32275-32283 Journal of Biological Chemistry, 278, 34, 32275-32283 2003 Refereed English Disclose to all
H. Kazeto; S. Nomura; N. Ito; T. Ito; Y. Watanabe; H. Kajiyama; K. Shibata; K. Ino; K. Tamakoshi; A. Hattori; F. Kikkawa; T. Nagasaka; M. Tsujimoto; S. Mizutani H. Kazeto; S. Nomura; N. Ito; T. Ito; Y. Watanabe; H. Kajiyama; K. Shibata; K. Ino; K. Tamakoshi; A. Hattori; F. Kikkawa; T. Nagasaka; M. Tsujimoto; S. Mizutani H. Kazeto; S. Nomura; N. Ito; T. Ito; Y. Watanabe; H. Kajiyama; K. Shibata; K. Ino; K. Tamakoshi; A. Hattori; F. Kikkawa; T. Nagasaka; M. Tsujimoto; S. Mizutani Expression of adipocyte-derived leucine aminopeptidase in endometrial cancer: Association with tumor grade and CA-125 Expression of adipocyte-derived leucine aminopeptidase in endometrial cancer: Association with tumor grade and CA-125 Expression of adipocyte-derived leucine aminopeptidase in endometrial cancer: Association with tumor grade and CA-125 Tumor Biology, 24, 4, 203-208 Tumor Biology, 24, 4, 203-208 Tumor Biology, 24, 4, 203-208 2003 Refereed English Disclose to all
K. Ino; F. Kikkawa; T. Suzuki; H. Kajiyama; K. Shibata; S. Nomura; A. Itakura; M. Ito; T. Nagasaka; A. Hattori; M. Tsujimoto; S. Mizutani K. Ino; F. Kikkawa; T. Suzuki; H. Kajiyama; K. Shibata; S. Nomura; A. Itakura; M. Ito; T. Nagasaka; A. Hattori; M. Tsujimoto; S. Mizutani K. Ino; F. Kikkawa; T. Suzuki; H. Kajiyama; K. Shibata; S. Nomura; A. Itakura; M. Ito; T. Nagasaka; A. Hattori; M. Tsujimoto; S. Mizutani Expression of Placental Leucine Aminopeptidase and Adipocyte-Derived Leucine Aminopeptidase in Human Normal and Malignant Invasive Trophoblastic Cells Expression of Placental Leucine Aminopeptidase and Adipocyte-Derived Leucine Aminopeptidase in Human Normal and Malignant Invasive Trophoblastic Cells Expression of Placental Leucine Aminopeptidase and Adipocyte-Derived Leucine Aminopeptidase in Human Normal and Malignant Invasive Trophoblastic Cells Laboratory Investigation, 83, 12, 1799-1809 Laboratory Investigation, 83, 12, 1799-1809 Laboratory Investigation, 83, 12, 1799-1809 2003 Refereed English Disclose to all
Y. Nomura; Y. Abe; Y. Ishii; M. Watanabe; M. Kobayashi; A. Hattori; M. Tsujimoto Y. Nomura; Y. Abe; Y. Ishii; M. Watanabe; M. Kobayashi; A. Hattori; M. Tsujimoto Y. Nomura; Y. Abe; Y. Ishii; M. Watanabe; M. Kobayashi; A. Hattori; M. Tsujimoto Structural changes in the glycosaminoglycan chain of rat skin decorin with growth Structural changes in the glycosaminoglycan chain of rat skin decorin with growth Structural changes in the glycosaminoglycan chain of rat skin decorin with growth Journal of Dermatology, 30, 9, 655-664 Journal of Dermatology, 30, 9, 655-664 Journal of Dermatology, 30, 9, 655-664 2003 Refereed English Disclose to all
Y. Watanabe; K. Shibata; F. Kikkawa; H. Kajiyama; K. Ino; A. Hattori; M. Tsujimoto; S. Mizutani Y. Watanabe; K. Shibata; F. Kikkawa; H. Kajiyama; K. Ino; A. Hattori; M. Tsujimoto; S. Mizutani Y. Watanabe; K. Shibata; F. Kikkawa; H. Kajiyama; K. Ino; A. Hattori; M. Tsujimoto; S. Mizutani Adipocyte-Derived Leucine Aminopeptidase Suppresses Angiogenesis in Human Endometrial Carcinoma via Renin-Angiotensin System Adipocyte-Derived Leucine Aminopeptidase Suppresses Angiogenesis in Human Endometrial Carcinoma via Renin-Angiotensin System Adipocyte-Derived Leucine Aminopeptidase Suppresses Angiogenesis in Human Endometrial Carcinoma via Renin-Angiotensin System Clinical Cancer Research, 9, 17, 6497-6503 Clinical Cancer Research, 9, 17, 6497-6503 Clinical Cancer Research, 9, 17, 6497-6503 2003 Refereed English Disclose to all
T. Saric; S.-C. Chang; A. Hattori; I.A. York; S. Markant; K.L. Rock; M. Tsujimoto; A.L. Goldberg T. Saric; S.-C. Chang; A. Hattori; I.A. York; S. Markant; K.L. Rock; M. Tsujimoto; A.L. Goldberg T. Saric; S.-C. Chang; A. Hattori; I.A. York; S. Markant; K.L. Rock; M. Tsujimoto; A.L. Goldberg An IFN-γ-induced aminopeptidase in the ER, ERAP I, trims precursors to MHC class I-presented peptides An IFN-γ-induced aminopeptidase in the ER, ERAP I, trims precursors to MHC class I-presented peptides An IFN-γ-induced aminopeptidase in the ER, ERAP I, trims precursors to MHC class I-presented peptides Nature Immunology, 3, 12, 1169-1176 Nature Immunology, 3, 12, 1169-1176 Nature Immunology, 3, 12, 1169-1176 2002 Refereed English Disclose to all
Akira Hattori, Ken Matsumoto, Shigehiko Mizutani, Masafumi Tsujimoto Akira Hattori, Ken Matsumoto, Shigehiko Mizutani, Masafumi Tsujimoto Akira Hattori, Ken Matsumoto, Shigehiko Mizutani, Masafumi Tsujimoto Genomic organization of the human adipocyte-derived leucine aminopeptidase gene and its relationship to the placental leucine aminopeptidase/oxytocinase gene Genomic organization of the human adipocyte-derived leucine aminopeptidase gene and its relationship to the placental leucine aminopeptidase/oxytocinase gene Genomic organization of the human adipocyte-derived leucine aminopeptidase gene and its relationship to the placental leucine aminopeptidase/oxytocinase gene Journal of Biochemistry, 130, 235-241 Journal of Biochemistry, 130, 235-241 Journal of Biochemistry, 130, 235-241 2001/01/01 Disclose to all
H. Matsumoto; T. Nagasaka; A. Hattori; T. Rogi; N. Tsuruoka; S. Mizutani; M. Tsujimoto H. Matsumoto; T. Nagasaka; A. Hattori; T. Rogi; N. Tsuruoka; S. Mizutani; M. Tsujimoto H. Matsumoto; T. Nagasaka; A. Hattori; T. Rogi; N. Tsuruoka; S. Mizutani; M. Tsujimoto Expression of placental leucine aminopeptidase/oxytocinase in neuronal cells and its action on neuronal peptides Expression of placental leucine aminopeptidase/oxytocinase in neuronal cells and its action on neuronal peptides Expression of placental leucine aminopeptidase/oxytocinase in neuronal cells and its action on neuronal peptides European Journal of Biochemistry, 268, 11, 3259-3266 European Journal of Biochemistry, 268, 11, 3259-3266 European Journal of Biochemistry, 268, 11, 3259-3266 2001 Refereed English Disclose to all
Akira Hattori, Kenji Kitatani, Hideko Matsumoto, Shinobu Miyazawa, Tomohiro Rogi, Nobuo Tsuruoka, Shigehiko Mizutani, Yasuhiro Natori, Masafumi Tsujimoto Akira Hattori, Kenji Kitatani, Hideko Matsumoto, Shinobu Miyazawa, Tomohiro Rogi, Nobuo Tsuruoka, Shigehiko Mizutani, Yasuhiro Natori, Masafumi Tsujimoto Akira Hattori, Kenji Kitatani, Hideko Matsumoto, Shinobu Miyazawa, Tomohiro Rogi, Nobuo Tsuruoka, Shigehiko Mizutani, Yasuhiro Natori, Masafumi Tsujimoto Characterization of recombinant human adipocyte-derived leucine aminopeptidase expressed in Chinese hamster ovary cells Characterization of recombinant human adipocyte-derived leucine aminopeptidase expressed in Chinese hamster ovary cells Characterization of recombinant human adipocyte-derived leucine aminopeptidase expressed in Chinese hamster ovary cells Journal of Biochemistry, 128, 755-762 Journal of Biochemistry, 128, 755-762 Journal of Biochemistry, 128, 755-762 2000/01/01 Disclose to all
Y. Nakanishi; S. Nomura; M. Okada; T. Ito; Y. Katsumata; F. Kikkawa; A. Hattori; M. Tsujimoto; S. Mizutani Y. Nakanishi; S. Nomura; M. Okada; T. Ito; Y. Katsumata; F. Kikkawa; A. Hattori; M. Tsujimoto; S. Mizutani Y. Nakanishi; S. Nomura; M. Okada; T. Ito; Y. Katsumata; F. Kikkawa; A. Hattori; M. Tsujimoto; S. Mizutani Immunoaffinity purification and characterization of native placental leucine aminopeptidase/oxytocinase from human placenta Immunoaffinity purification and characterization of native placental leucine aminopeptidase/oxytocinase from human placenta Immunoaffinity purification and characterization of native placental leucine aminopeptidase/oxytocinase from human placenta Placenta, 21, 7, 628-634 Placenta, 21, 7, 628-634 Placenta, 21, 7, 628-634 2000 Refereed English Disclose to all
H. Matsumoto; T. Rogi; K. Yamashiro; S. Kodama; N. Tsuruoka; A. Hattori; K. Takio; S. Mizutani; M. Tsujimoto H. Matsumoto; T. Rogi; K. Yamashiro; S. Kodama; N. Tsuruoka; A. Hattori; K. Takio; S. Mizutani; M. Tsujimoto H. Matsumoto; T. Rogi; K. Yamashiro; S. Kodama; N. Tsuruoka; A. Hattori; K. Takio; S. Mizutani; M. Tsujimoto Characterization of a recombinant soluble form of human placental leucine aminopeptidase/oxytocinase expressed in Chinese hamster ovary cells Characterization of a recombinant soluble form of human placental leucine aminopeptidase/oxytocinase expressed in Chinese hamster ovary cells Characterization of a recombinant soluble form of human placental leucine aminopeptidase/oxytocinase expressed in Chinese hamster ovary cells European Journal of Biochemistry, 267, 1, 46-52 European Journal of Biochemistry, 267, 1, 46-52 European Journal of Biochemistry, 267, 1, 46-52 2000 Refereed English Disclose to all
A. Hattori; M. Katayama; S. Iwasaki; K. Ishii; M. Tsujimoto; M. Kohno A. Hattori; M. Katayama; S. Iwasaki; K. Ishii; M. Tsujimoto; M. Kohno A. Hattori; M. Katayama; S. Iwasaki; K. Ishii; M. Tsujimoto; M. Kohno Bone morphogenetic protein-2 promotes survival and differentiation of striatal GABAergic neurons in the absence of glial cell proliferation Bone morphogenetic protein-2 promotes survival and differentiation of striatal GABAergic neurons in the absence of glial cell proliferation Bone morphogenetic protein-2 promotes survival and differentiation of striatal GABAergic neurons in the absence of glial cell proliferation Journal of Neurochemistry, 72, 6, 2264-2271 Journal of Neurochemistry, 72, 6, 2264-2271 Journal of Neurochemistry, 72, 6, 2264-2271 1999 Refereed English Disclose to all
A. Hattori; H. Matsumoto; S. Mizutani; M. Tsujimoto A. Hattori; H. Matsumoto; S. Mizutani; M. Tsujimoto A. Hattori; H. Matsumoto; S. Mizutani; M. Tsujimoto Molecular cloning of adipocyte-derived leucine aminopeptidase highly related to placental leucine aminopeptidase/oxytocinase Molecular cloning of adipocyte-derived leucine aminopeptidase highly related to placental leucine aminopeptidase/oxytocinase Molecular cloning of adipocyte-derived leucine aminopeptidase highly related to placental leucine aminopeptidase/oxytocinase Journal of Biochemistry, 125, 5, 931-938 Journal of Biochemistry, 125, 5, 931-938 Journal of Biochemistry, 125, 5, 931-938 1999 Refereed English Disclose to all
A. Hattori; K. Hayashi; M. Kohno A. Hattori; K. Hayashi; M. Kohno A. Hattori; K. Hayashi; M. Kohno Tumor necrosis factor (TNF) stimulates the production of nerve growth factor in fibroblasts via the 55-kDa type 1 TNF receptor Tumor necrosis factor (TNF) stimulates the production of nerve growth factor in fibroblasts via the 55-kDa type 1 TNF receptor Tumor necrosis factor (TNF) stimulates the production of nerve growth factor in fibroblasts via the 55-kDa type 1 TNF receptor FEBS Letters, 379, 2, 157-160 FEBS Letters, 379, 2, 157-160 FEBS Letters, 379, 2, 157-160 1996 Refereed English Disclose to all
S. Iwasaki; A. Hattori; M. Sato; M. Tsujimoto; M. Kohno S. Iwasaki; A. Hattori; M. Sato; M. Tsujimoto; M. Kohno S. Iwasaki; A. Hattori; M. Sato; M. Tsujimoto; M. Kohno Characterization of the bone morphogenetic protein-2 as a neurotrophic factor. Induction of neuronal differentiation of PC12 cells in the absence of mitogen-activated protein kinase activation Characterization of the bone morphogenetic protein-2 as a neurotrophic factor. Induction of neuronal differentiation of PC12 cells in the absence of mitogen-activated protein kinase activation Characterization of the bone morphogenetic protein-2 as a neurotrophic factor. Induction of neuronal differentiation of PC12 cells in the absence of mitogen-activated protein kinase activation Journal of Biological Chemistry, 271, 29, 17360-17365 Journal of Biological Chemistry, 271, 29, 17360-17365 Journal of Biological Chemistry, 271, 29, 17360-17365 1996 Refereed English Disclose to all
A. Hattori; M. Tsujimoto; K. Hayashi; M. Kohno A. Hattori; M. Tsujimoto; K. Hayashi; M. Kohno A. Hattori; M. Tsujimoto; K. Hayashi; M. Kohno Bone morphogenetic protein-2 is markedly synergistic with tumor necrosis factor in stimulating the production of nerve growth factor in fibroblasts Bone morphogenetic protein-2 is markedly synergistic with tumor necrosis factor in stimulating the production of nerve growth factor in fibroblasts Bone morphogenetic protein-2 is markedly synergistic with tumor necrosis factor in stimulating the production of nerve growth factor in fibroblasts Biochemistry and Molecular Biology International, 38, 6, 1095-1101 Biochemistry and Molecular Biology International, 38, 6, 1095-1101 Biochemistry and Molecular Biology International, 38, 6, 1095-1101 1996 Refereed English Disclose to all
S. Iwasaki; N. Tsuruoka; A. Hattori; M. Sato; M. Tsujimoto; M. Kohno S. Iwasaki; N. Tsuruoka; A. Hattori; M. Sato; M. Tsujimoto; M. Kohno S. Iwasaki; N. Tsuruoka; A. Hattori; M. Sato; M. Tsujimoto; M. Kohno Distribution and characterization of specific cellular binding proteins for bone morphogenetic protein-2 Distribution and characterization of specific cellular binding proteins for bone morphogenetic protein-2 Distribution and characterization of specific cellular binding proteins for bone morphogenetic protein-2 Journal of Biological Chemistry, 270, 10, 5476-5482 Journal of Biological Chemistry, 270, 10, 5476-5482 Journal of Biological Chemistry, 270, 10, 5476-5482 1995 Refereed English Disclose to all
Y. Chatani; S. Tanimura; N. Miyoshi; A. Hattori; M. Sato; M. Kohno Y. Chatani; S. Tanimura; N. Miyoshi; A. Hattori; M. Sato; M. Kohno Y. Chatani; S. Tanimura; N. Miyoshi; A. Hattori; M. Sato; M. Kohno Cell type-specific modulation of cell growth by transforming growth factor β1 does not correlate with mitogen-activated protein kinase activation Cell type-specific modulation of cell growth by transforming growth factor β1 does not correlate with mitogen-activated protein kinase activation Cell type-specific modulation of cell growth by transforming growth factor β1 does not correlate with mitogen-activated protein kinase activation Journal of Biological Chemistry, 270, 51, 30686-30692 Journal of Biological Chemistry, 270, 51, 30686-30692 Journal of Biological Chemistry, 270, 51, 30686-30692 1995 Refereed English Disclose to all
K. Murase; A. Hattori; M. Kohno; K. Hayashi K. Murase; A. Hattori; M. Kohno; K. Hayashi K. Murase; A. Hattori; M. Kohno; K. Hayashi Stimulation of nerve growth factor synthesis/secretion in mouse astroglial cells by coenzymes Stimulation of nerve growth factor synthesis/secretion in mouse astroglial cells by coenzymes Stimulation of nerve growth factor synthesis/secretion in mouse astroglial cells by coenzymes Biochemistry and Molecular Biology International, 30, 4, 615-621 Biochemistry and Molecular Biology International, 30, 4, 615-621 Biochemistry and Molecular Biology International, 30, 4, 615-621 1993 Refereed English Disclose to all
A. Hattori; E. Tanaka; K. Murase; N. Ishida; Y. Chatani; M. Tsujimoto; K. Hayashi; M. Kohno A. Hattori; E. Tanaka; K. Murase; N. Ishida; Y. Chatani; M. Tsujimoto; K. Hayashi; M. Kohno A. Hattori; E. Tanaka; K. Murase; N. Ishida; Y. Chatani; M. Tsujimoto; K. Hayashi; M. Kohno Tumor necrosis factor stimulates the synthesis and secretion of biologically active nerve growth factor in non-neuronal cells Tumor necrosis factor stimulates the synthesis and secretion of biologically active nerve growth factor in non-neuronal cells Tumor necrosis factor stimulates the synthesis and secretion of biologically active nerve growth factor in non-neuronal cells Journal of Biological Chemistry, 268, 4, 2577-2582 Journal of Biological Chemistry, 268, 4, 2577-2582 Journal of Biological Chemistry, 268, 4, 2577-2582 1993 Refereed English Disclose to all
Y. Chatani; A. Itoh; E. Tanaka; A. Hattori; T. Nakamura; M. Kohno Y. Chatani; A. Itoh; E. Tanaka; A. Hattori; T. Nakamura; M. Kohno Y. Chatani; A. Itoh; E. Tanaka; A. Hattori; T. Nakamura; M. Kohno Hepatocyte growth factor rapidly induces the tyrosine phosphorylation of 41-kDa and 43-kDa proteins in mouse keratinocytes Hepatocyte growth factor rapidly induces the tyrosine phosphorylation of 41-kDa and 43-kDa proteins in mouse keratinocytes Hepatocyte growth factor rapidly induces the tyrosine phosphorylation of 41-kDa and 43-kDa proteins in mouse keratinocytes Biochemical and Biophysical Research Communications, 185, 3, 860-866 Biochemical and Biophysical Research Communications, 185, 3, 860-866 Biochemical and Biophysical Research Communications, 185, 3, 860-866 1992 Refereed English Disclose to all
M. Kohno; Y. Chatani; E. Tanaka; A. Hattori; N. Nishizawa M. Kohno; Y. Chatani; E. Tanaka; A. Hattori; N. Nishizawa M. Kohno; Y. Chatani; E. Tanaka; A. Hattori; N. Nishizawa Mitogen-induced tyrosine phosphorylation of 41 kDa and 43 kDa proteins: Potential role in integrating multiple mitogenic signalling pathways Mitogen-induced tyrosine phosphorylation of 41 kDa and 43 kDa proteins: Potential role in integrating multiple mitogenic signalling pathways Mitogen-induced tyrosine phosphorylation of 41 kDa and 43 kDa proteins: Potential role in integrating multiple mitogenic signalling pathways Biochemical Journal, 287, 3, 917-924 Biochemical Journal, 287, 3, 917-924 Biochemical Journal, 287, 3, 917-924 1992 Refereed English Disclose to all
Y. Chatani; E. Tanaka; K. Tobe; A. Hattori; M. Sato; H. Tamemoto; N. Nishizawa; H. Nomoto; T. Takeya; T. Kadowaki; M. Kasuga; M. Kohno Y. Chatani; E. Tanaka; K. Tobe; A. Hattori; M. Sato; H. Tamemoto; N. Nishizawa; H. Nomoto; T. Takeya; T. Kadowaki; M. Kasuga; M. Kohno Y. Chatani; E. Tanaka; K. Tobe; A. Hattori; M. Sato; H. Tamemoto; N. Nishizawa; H. Nomoto; T. Takeya; T. Kadowaki; M. Kasuga; M. Kohno Mitogen-induced tyrosine-phosphorylated 41- and 43-kDa proteins are family members of extracellular signal-regulated kinases/microtubule-associated protein 2 kinases Mitogen-induced tyrosine-phosphorylated 41- and 43-kDa proteins are family members of extracellular signal-regulated kinases/microtubule-associated protein 2 kinases Mitogen-induced tyrosine-phosphorylated 41- and 43-kDa proteins are family members of extracellular signal-regulated kinases/microtubule-associated protein 2 kinases Journal of Biological Chemistry, 267, 14, 9911-9916 Journal of Biological Chemistry, 267, 14, 9911-9916 Journal of Biological Chemistry, 267, 14, 9911-9916 1992 Refereed English Disclose to all

  • <<
  • >>
Title language:
Misc
Author Author(Japanese) Author(English) Title Title(Japanese) Title(English) Bibliography Bibliography(Japanese) Bibliography(English) Publication date Refereed paper Language Publishing type Disclose
Aya Yoshimura, Shinichi Nishimura, Saori Otsuka, Akira Hattori, Hideaki Kakeya Aya Yoshimura, Shinichi Nishimura, Saori Otsuka, Akira Hattori, Hideaki Kakeya Aya Yoshimura, Shinichi Nishimura, Saori Otsuka, Akira Hattori, Hideaki Kakeya Structure Elucidation of Verucopeptin, a HIF-1 Inhibitory Polyketide-Hexapeptide Hybrid Metabolite from an Actinomycete Structure Elucidation of Verucopeptin, a HIF-1 Inhibitory Polyketide-Hexapeptide Hybrid Metabolite from an Actinomycete Structure Elucidation of Verucopeptin, a HIF-1 Inhibitory Polyketide-Hexapeptide Hybrid Metabolite from an Actinomycete Organic Letters, 17, 5364-5367 Organic Letters, 17, 5364-5367 Organic Letters, 17, 5364-5367 2015/11/06 Disclose to all
M. Kohno, A. Hattori, H. Yamaguchi M. Kohno, A. Hattori, H. Yamaguchi M. Kohno, A. Hattori, H. Yamaguchi Application of NGF/PC12 cell system for screening tubulin inhibitors Application of NGF/PC12 cell system for screening tubulin inhibitors Application of NGF/PC12 cell system for screening tubulin inhibitors Japanese Journal of Cancer and Chemotherapy, 24, 164-177 Japanese Journal of Cancer and Chemotherapy, 24, 164-177 Japanese Journal of Cancer and Chemotherapy, 24, 164-177 1997/09/22 Disclose to all
Akira Hattori, Akira Hattori, Shoji Iwasaki, Katsuhito Murase, Masafumi Tsujimoto, Masahiro Sato, Kyozo Hayashi, Michiaki Kohno Akira Hattori, Akira Hattori, Shoji Iwasaki, Katsuhito Murase, Masafumi Tsujimoto, Masahiro Sato, Kyozo Hayashi, Michiaki Kohno Akira Hattori, Akira Hattori, Shoji Iwasaki, Katsuhito Murase, Masafumi Tsujimoto, Masahiro Sato, Kyozo Hayashi, Michiaki Kohno Tumor necrosis factor is markedly synergistic with interleukin 1 and interferon-γ in stimulating the production of nerve growth factor in fibroblasts Tumor necrosis factor is markedly synergistic with interleukin 1 and interferon-γ in stimulating the production of nerve growth factor in fibroblasts Tumor necrosis factor is markedly synergistic with interleukin 1 and interferon-γ in stimulating the production of nerve growth factor in fibroblasts FEBS Letters, 340, 177-180 FEBS Letters, 340, 177-180 FEBS Letters, 340, 177-180 1994/03/07 Disclose to all
Title language:
Conference Activities & Talks
Title Title(Japanese) Title(English) Conference Conference(Japanese) Conference(English) Promotor Promotor(Japanese) Promotor(English) Date Language Assortment Disclose
TGF-βシグナル伝達阻害剤KUSC-Y244はTGF-βによる上皮間葉転換を抑制する TGF-βシグナル伝達阻害剤KUSC-Y244はTGF-βによる上皮間葉転換を抑制する TGF-βシグナル伝達阻害剤KUSC-Y244はTGF-βによる上皮間葉転換を抑制する 2018/03/27 Poster presentation Disclose to all
脱ユビキチン化酵素USP47のポリユビキチン鎖消化に関わる分子内領域の同定 脱ユビキチン化酵素USP47のポリユビキチン鎖消化に関わる分子内領域の同定 脱ユビキチン化酵素USP47のポリユビキチン鎖消化に関わる分子内領域の同定 第89回日本生化学会大会 第89回日本生化学会大会 第89回日本生化学会大会 2016/09/27 Poster presentation Disclose to all
脱ユビキチン化酵素阻害によるHIF-1発現レベルの制御. 脱ユビキチン化酵素阻害によるHIF-1発現レベルの制御. 脱ユビキチン化酵素阻害によるHIF-1発現レベルの制御. 2016/09/27 Poster presentation Disclose to all
脱ユビキチン化酵素USP47の活性発現におけるC末端領域の役割 脱ユビキチン化酵素USP47の活性発現におけるC末端領域の役割 脱ユビキチン化酵素USP47の活性発現におけるC末端領域の役割 第19回日本病態プロテアーゼ学会学術集会 第19回日本病態プロテアーゼ学会学術集会 第19回日本病態プロテアーゼ学会学術集会 2014 Disclose to all
脱Urm1化活性の検出および分子同定 脱Urm1化活性の検出および分子同定 脱Urm1化活性の検出および分子同定 日本薬学会134年会 日本薬学会134年会 日本薬学会134年会 2014 Disclose to all
脱ユビキチン化酵素(USP)47の分子内ドメインの機能解析 脱ユビキチン化酵素(USP)47の分子内ドメインの機能解析 脱ユビキチン化酵素(USP)47の分子内ドメインの機能解析 日本薬学会134年会 日本薬学会134年会 日本薬学会134年会 2014 Disclose to all
脱ユビキチン化酵素(USP)47の活性発現機構の解析 脱ユビキチン化酵素(USP)47の活性発現機構の解析 脱ユビキチン化酵素(USP)47の活性発現機構の解析 日本薬学会第133年会 日本薬学会第133年会 日本薬学会第133年会 2013 Disclose to all
脱ユビキチン化酵素(USP)47の活性発現における分子内ユビキチン様ドメインの役割 脱ユビキチン化酵素(USP)47の活性発現における分子内ユビキチン様ドメインの役割 脱ユビキチン化酵素(USP)47の活性発現における分子内ユビキチン様ドメインの役割 第85回日本生化学会 第85回日本生化学会 第85回日本生化学会 2012 Disclose to all
脱ユビキチン化酵素UCH-L3は酸化ストレスの標的タンパク質である 脱ユビキチン化酵素UCH-L3は酸化ストレスの標的タンパク質である 脱ユビキチン化酵素UCH-L3は酸化ストレスの標的タンパク質である 第85回日本生化学会 第85回日本生化学会 第85回日本生化学会 2012 Disclose to all
Activity-based Profillingによる酸化ストレス感受性脱ユビキチン化酵素の同定 Activity-based Profillingによる酸化ストレス感受性脱ユビキチン化酵素の同定 Activity-based Profillingによる酸化ストレス感受性脱ユビキチン化酵素の同定 日本ケミカルバイオロジー学会 第7回年会 日本ケミカルバイオロジー学会 第7回年会 日本ケミカルバイオロジー学会 第7回年会 2012 Disclose to all
脱ユビキチン化酵素UCH-L3は酸化ストレス下で不活性化され 脱ユビキチン化酵素UCH-L3は酸化ストレス下で不活性化され 脱ユビキチン化酵素UCH-L3は酸化ストレス下で不活性化され 日本薬学会第132年会 日本薬学会第132年会 日本薬学会第132年会 2012 Disclose to all
ヒトUSP47の脱ユビキチン化酵素活性の解析 ヒトUSP47の脱ユビキチン化酵素活性の解析 ヒトUSP47の脱ユビキチン化酵素活性の解析 2012 Disclose to all
ヒトC7orf24の遺伝子発現は、転写開始点近傍の3ヶ所のCCAAT配列に制御される ヒトC7orf24の遺伝子発現は、転写開始点近傍の3ヶ所のCCAAT配列に制御される ヒトC7orf24の遺伝子発現は、転写開始点近傍の3ヶ所のCCAAT配列に制御される 第84回日本生化学会 第84回日本生化学会 第84回日本生化学会 2011 Disclose to all
グランザイムBをレポーターに用いた脱ユビキチン化酵素活性測定法の構築 グランザイムBをレポーターに用いた脱ユビキチン化酵素活性測定法の構築 グランザイムBをレポーターに用いた脱ユビキチン化酵素活性測定法の構築 第84回日本生化学会 第84回日本生化学会 第84回日本生化学会 2011 Disclose to all
脱ユビキチン化酵素活性の新しい測定法の確立 脱ユビキチン化酵素活性の新しい測定法の確立 脱ユビキチン化酵素活性の新しい測定法の確立 日本薬学会第131年会 日本薬学会第131年会 日本薬学会第131年会 2011 Disclose to all
ヒト脱ユビキチン化酵素USP47の酵素学的性状解析 ヒト脱ユビキチン化酵素USP47の酵素学的性状解析 ヒト脱ユビキチン化酵素USP47の酵素学的性状解析 83回日本生化学会大会・第33回日本分子生物学会年会合同大会: 83回日本生化学会大会・第33回日本分子生物学会年会合同大会: 83回日本生化学会大会・第33回日本分子生物学会年会合同大会: 2010 Disclose to all
C7orf24/GGCTの転写はNF-Yにより活性化される C7orf24/GGCTの転写はNF-Yにより活性化される C7orf24/GGCTの転写はNF-Yにより活性化される 83回日本生化学会大会・第33回日本分子生物学会年会合同大会: 83回日本生化学会大会・第33回日本分子生物学会年会合同大会: 83回日本生化学会大会・第33回日本分子生物学会年会合同大会: 2010 Disclose to all
新規癌関連因子ヒトC7orf24の転写制御機構の解析 新規癌関連因子ヒトC7orf24の転写制御機構の解析 新規癌関連因子ヒトC7orf24の転写制御機構の解析 第13回日本癌分子標的治療学会 第13回日本癌分子標的治療学会 第13回日本癌分子標的治療学会 2009 Disclose to all
HIF-1機能制御化合物の評価系構築と探索研究 HIF-1機能制御化合物の評価系構築と探索研究 HIF-1機能制御化合物の評価系構築と探索研究 日本薬学会第129年会 日本薬学会第129年会 日本薬学会第129年会 2009 Disclose to all

  • <<
  • >>
Title language:
Industrial Property Rights (Patent)
Inventor(s) Inventor(s) (Japanese) Inventor(s) (English) Title Title(Japanese) Title(English) Stage Patent number Date Disclose
掛谷 秀昭, 西村 慎一, 服部 明, 岸本 真治, 波多野 和樹, 五十嵐 雅之 掛谷 秀昭, 西村 慎一, 服部 明, 岸本 真治, 波多野 和樹, 五十嵐 雅之 掛谷 秀昭, 西村 慎一, 服部 明, 岸本 真治, 波多野 和樹, 五十嵐 雅之 新規生物活性物質 新規生物活性物質 新規生物活性物質 特許登録 特許第6270547号 2018/01/12 Disclose to all
掛谷 秀昭, 西村 慎一, 服部 明, 岸本 真治, 波多野 和樹, 五十嵐 雅之 掛谷 秀昭, 西村 慎一, 服部 明, 岸本 真治, 波多野 和樹, 五十嵐 雅之 掛谷 秀昭, 西村 慎一, 服部 明, 岸本 真治, 波多野 和樹, 五十嵐 雅之 新規生物活性物質 新規生物活性物質 新規生物活性物質 特許公開 特開2015-166329 2015/09/24 Disclose to all
掛谷 秀昭, 酒井 佑宜, 服部 明, 西村 慎一, 岡村 均, 土居 雅夫 掛谷 秀昭, 酒井 佑宜, 服部 明, 西村 慎一, 岡村 均, 土居 雅夫 掛谷 秀昭, 酒井 佑宜, 服部 明, 西村 慎一, 岡村 均, 土居 雅夫 3β−ヒドロキシステロイドデヒドロゲナーゼ阻害剤 3β−ヒドロキシステロイドデヒドロゲナーゼ阻害剤 3β−ヒドロキシステロイドデヒドロゲナーゼ阻害剤 特許公開 特開2014-097954 2014/05/29 Disclose to all
掛谷 秀昭, 服部 明, 高須 康明, 藤井 信孝, 大石 真也, 小嶋 聡一, 原 詳子 掛谷 秀昭, 服部 明, 高須 康明, 藤井 信孝, 大石 真也, 小嶋 聡一, 原 詳子 掛谷 秀昭, 服部 明, 高須 康明, 藤井 信孝, 大石 真也, 小嶋 聡一, 原 詳子 TGF−βシグナル伝達阻害剤 TGF−βシグナル伝達阻害剤 TGF−βシグナル伝達阻害剤 特許公開 WO2011-102436 2011/08/25 Disclose to all
Title language:
External funds: competitive funds and Grants-in-Aid for Scientific Research (Kakenhi)
Type Position Title(Japanese) Title(English) Period
挑戦的萌芽研究 Assignment 小胞体アミノペプチダーゼの双極性障害発症への関与-モデル動物としての評価・確立- 2015/04/01-2017/03/31
基盤研究(B) Assignment 胚由来の胚着床誘導因子(胚シグナル)の同定と臨床応用への試み 2014/04/01-2017/03/31
基盤研究(B) Assignment M1アミノペプチダーゼ機能異常と自己免疫疾患病態の分子機構 2014/04/01-2016/03/31
基盤研究(B) Assignment 分子ひずみの付与と解消を機軸とする新規分子変換法の開発と生理活性物質創製 2013/04/01-2016/03/31
挑戦的萌芽研究 Assignment ヒト栄養膜細胞に特異的な新規液性因子laeverinによる免疫寛容誘導機構の解析 Induction of immune-tolerance by a novel human trophoblast-specific soluble factor, laeverin 2012/04/01-2013/03/31
挑戦的萌芽研究 Assignment アミノペプチダーゼの動脈硬化症への関与 2012/04/01-2014/03/31
挑戦的萌芽研究 Representative 新しいスキャフォルド分子の生成機構とその生理的意義 Mechanism of unanchored polyubiquitin chain production 2012/04/01-2014/03/31
基盤研究(B) Assignment 胚特異的糖鎖抗原を介した母体の胚認識および胚着床・胎盤形成誘導機構の解析 Analysis of maternal recognition through embryo-specific sugar antigen and its inducing mechanisms for embryo implantation and placentation 2011/04/01-2014/03/31
新学術領域研究(研究領域提案型) Representative 抗原トリミングアミノペプチダーゼの作用発現メカニズムと制御 2011/04/01-2013/03/31
基盤研究(B) Representative 活性動態の理解に基づいた脱ユビキチン化酵素の機能解明 Biochemical and physiological studies on deubiquitinating enzymes based on an analysis of the enzymatic activity dynamics 2011/04/01-2014/03/31
挑戦的萌芽研究 Assignment 免疫系による発生初期胚の認識機構-透明帯を利用した哺乳類の着床誘導戦略の証明- 2010/04/01-2011/03/31
基盤研究(B) Assignment 生殖過程における組織再構築機構の解析ー体循環細胞による再生機序の解明を目指してー Analysis of tissue remodeling mechanisms by circulating blood cells during human reproduction 2008/04/01-2011/03/31
基盤研究(C) Representative ユニークな組織発現・細胞内局在を持つM1アミノペプチダーゼの生理機能の解明 Biological Function of the M1 Family of Human Aminopeptidases 2008/04/01-2011/03/31
基盤研究(B) Assignment 多機能性プロテアーゼ、オキシトシナーゼサブファミリーの作用メカニズム研究 Mechanisms of Enzymatic Action of the Oxytocinase Subfamily of Aminopeptidases 2006/04/01-2009/03/31
若手研究(B) Representative 小胞体におけるMHCクラスI提示抗原のN末端トリミング過程の分子メカニズム解析 2006/04/01-2008/03/31
萌芽研究 Assignment 血管新生の制御を目指した新たな標的分子の探索 2004/04/01-2006/03/31
若手研究(B) Representative 抗原ペプチドプロセシングにおける小胞体アミノペプチダーゼの作用メカニズムの解明 2004/04/01-2006/03/31
基盤研究(B)→基盤研究(B) Assignment 新規オキシトシナーゼサブファミリーの生物薬学的研究 The oxytocinase subfamily of M1 aminopeptidases 2003/04/01-2006/03/31
若手研究(B) Representative オキシトシナーゼサブファミリーの細胞内膜系局在の意義およびそのメカニズムの解明 2002/04/01-2004/03/31
奨励研究(A) Representative オキシトシナーゼサブファミリーに属する新規酵素の生理機能の解明 2000/04/01-2002/03/31
基盤研究(B) Assignment 新規アミノペプチダーゼファミリーの構造とその生物学的意義 STRUCTURE AND FUNCTION OF NOVEL AMINOPEPTIDASES BELONGING TO OXYTOCINASE SUB-FAMILY 1999/04/01-2002/03/31
奨励研究(A) Representative 腫瘍壊死因子によるアポトーシス誘導のシグナル系におけるcPLA_2の役割の解明 1998/04/01-2000/03/31
基盤研究(C) Representative 脱ユビキチン化酵素阻害剤が駆動する新規HIF-1分解経路の同定 (平成28年度分) 2016/04/01-2017/03/31
基盤研究(C) Representative 脱ユビキチン化酵素阻害剤が駆動する新規HIF-1分解経路の同定 (平成29年度分) 2017/04/01-2018/03/31

  • <<
  • >>
External funds: other than those above
System Main person Title(Japanese) Title(English) Period
JST産学共同シーズイノベーション化事業 服部 明 高感度アミノペプチダーゼ定量法の開発と疾患診断法への応用化の検討 2005/10/01-2006/09/30
Teaching subject(s)
Name(Japanese) Name(English) Term Department Period
創薬リード探索技術 Drug Discovery & Development II: 後期不定 薬学研究科 2011/04-2012/03
リード化合物探索スキル Skill Development for Lead Discovery 通年不定 薬学研究科 2011/04-2012/03
リード化合物探索スキル(秋入学用) Skill Development for Lead Discovery 後期前期 薬学研究科 2011/04-2012/03
くすりの化学 Organic Chemistry of Pharmaceuticals 前期 全学共通科目 2011/04-2012/03
医薬創成プロセス概論 Introduction to Drug Discovery Sciences 前期不定 薬学研究科 2011/04-2012/03
医薬創成研究プロジェクト特論 Advanced Drug Discovery & Development I 前期不定 薬学研究科 2011/04-2012/03
医薬品化学・新薬論 後期 薬学部 2011/04-2012/03
天然物薬学2(薬用資源学) 後期 薬学部 2011/04-2012/03
新薬論 後期 薬学部 2011/04-2012/03
システム生物学・医薬創成系コンテンツ制作 Advanced Methods in Systems 通年不定 薬学研究科 2011/04-2012/03
システム生物学・医薬創成系コンテンツ制作(秋入学) Advanced Methods in Systems 後期前期 薬学研究科 2011/04-2012/03
システム生物学・医薬創成系研究 Research in Systems 通年不定 薬学研究科 2011/04-2012/03
システム生物学・医薬創成系研究(秋入学用) Research in Systems 後期前期 薬学研究科 2011/04-2012/03
薬学専門実習II 前期 薬学部 2011/04-2012/03
薬学専門実習2 前期 薬学部 2011/04-2012/03
薬用資源学 後期 薬学部 2011/04-2012/03
創薬リード探索技術 Drug Discovery & Development II: Lead Discovery Technology 後期不定 薬学研究科 2012/04-2013/03
リード化合物探索スキル Skill Development for Lead Discovery 通年不定 薬学研究科 2012/04-2013/03
医薬創成プロセス概論 Introduction to Drug Discovery Sciences 前期不定 薬学研究科 2012/04-2013/03
医薬品化学・新薬論 Medicinal Chemistry and Drug Discovery 後期 薬学部 2012/04-2013/03
天然物薬学2(薬用資源学) Pharmacognosy 2 (Pharmaceutical Resources) 後期 薬学部 2012/04-2013/03
新薬論 Discovery and Developmennt of New Drugs 後期 薬学部 2012/04-2013/03
システム生物学・医薬創成系コンテンツ制作 Advanced Methods in Systems Biology & Drug Discovery 通年不定 薬学研究科 2012/04-2013/03
システム生物学・医薬創成系研究 Research in Systems Biology & Drug Dicovery 通年不定 薬学研究科 2012/04-2013/03
薬学専門実習II Pharmaceutical Laboratory II:Organic Chemistry 前期 薬学部 2012/04-2013/03
薬学専門実習2 Pharmaceutical Laboratory 2 : Organic Chemistry 前期 薬学部 2012/04-2013/03
薬用資源学 Pharmaceutical Resources 後期 薬学部 2012/04-2013/03
天然物薬学1(天然物化学) Pharmacognogy 1 (Natural Product Chemistry) 前期 薬学部 2013/04-2014/03
薬学専門実習2 Pharmaceutical Laboratory 2 : Organic Chemistry 前期 薬学部 2013/04-2014/03
医薬創成プロセス概論 Introduction to Drug Discovery Sciences 前期不定 薬学研究科 2013/04-2014/03
リード化合物探索スキル Skill Development for Lead Discovery 通年不定 薬学研究科 2013/04-2014/03
システム生物学・医薬創成系研究 Research in Systems Biology & Drug Dicovery 通年不定 薬学研究科 2013/04-2014/03
システム生物学・医薬創成系コンテンツ制作 Advanced Methods in Systems Biology & Drug Discovery 通年不定 薬学研究科 2013/04-2014/03
くすりの化学 Organic Chemistry of Pharmaceuticals 前期 全学共通科目 2013/04-2014/03
天然物薬学1(天然物化学) Pharmacognogy 1 (Natural Product Chemistry) 前期 薬学部 2014/04-2015/03
薬学専門実習2 Pharmaceutical Laboratory 2 : Organic Chemistry 前期 薬学部 2014/04-2015/03
医薬創成プロセス概論 Introduction to Drug Discovery Sciences 前期不定 薬学研究科 2014/04-2015/03
創薬リード探索技術 Drug Discovery & Development II: Lead Discovery Technology 後期不定 薬学研究科 2014/04-2015/03
リード化合物探索スキル Skill Development for Lead Discovery 通年不定 薬学研究科 2014/04-2015/03
システム生物学・医薬創成系研究 Research in Systems Biology & Drug Dicovery 通年不定 薬学研究科 2014/04-2015/03
システム生物学・医薬創成系コンテンツ制作 Advanced Methods in Systems Biology & Drug Discovery 通年不定 薬学研究科 2014/04-2015/03
くすりの化学 Organic Chemistry of Pharmaceuticals 前期 全学共通科目 2014/04-2015/03
リード化合物探索スキル Skill Development for Lead Discovery 通年不定 薬学研究科 2015/04-2016/03
くすりの化学 Organic Chemistry of Pharmaceuticals 前期 全学共通科目 2015/04-2016/03
医薬創成プロセス概論 Introduction to Drug Discovery Sciences 前期不定 薬学研究科 2015/04-2016/03
天然物薬学1(天然物化学) Pharmacognogy 1 (Natural Product Chemistry) 前期 薬学部 2015/04-2016/03
システム生物学・医薬創成系コンテンツ制作 Advanced Methods in Systems Biology & Drug Discovery 通年不定 薬学研究科 2015/04-2016/03
システム生物学・医薬創成系研究 Research in Systems Biology & Drug Dicovery 通年不定 薬学研究科 2015/04-2016/03
薬学専門実習2 Pharmaceutical Laboratory 2 : Organic Chemistry 前期 薬学部 2015/04-2016/03
創薬リード探索技術 Drug Discovery & Development II: Lead Discovery Technology 後期不定 薬学研究科 2016/04-2017/03
リード化合物探索スキル Skill Development for Lead Discovery 通年不定 薬学研究科 2016/04-2017/03
医薬創成プロセス概論 Introduction to Drug Discovery Sciences 前期不定 薬学研究科 2016/04-2017/03
天然物薬学1(天然物化学) Pharmacognogy 1 (Natural Product Chemistry) 前期 薬学部 2016/04-2017/03
システム生物学・医薬創成系コンテンツ制作 Advanced Methods in Systems Biology & Drug Discovery 通年不定 薬学研究科 2016/04-2017/03
システム生物学・医薬創成系研究 Research in Systems Biology & Drug Dicovery 通年不定 薬学研究科 2016/04-2017/03
薬学専門実習2 Pharmaceutical Laboratory 2 : Organic Chemistry 前期 薬学部 2016/04-2017/03
ILASセミナー ILAS Seminar 前期 全学共通科目 2017/04-2018/03
創薬有機化学概論 Introduction to Organic Chemistry for Drug Discovery 前期不定 薬学研究科 2017/04-2018/03
リード化合物探索スキル Skill Development for Lead Discovery 通年不定 薬学研究科 2017/04-2018/03
天然物薬学1(天然物化学) Pharmacognogy 1 (Natural Product Chemistry) 前期 薬学部 2017/04-2018/03
システム生物学・医薬創成系コンテンツ制作 Advanced Methods in Systems Biology & Drug Discovery 通年不定 薬学研究科 2017/04-2018/03
システム生物学・医薬創成系研究 Research in Systems Biology & Drug Dicovery 通年不定 薬学研究科 2017/04-2018/03
薬学専門実習2 Pharmaceutical Laboratory 2 : Organic Chemistry 前期 薬学部 2017/04-2018/03
創薬リード探索技術 Drug Discovery & Development II: Lead Discovery Technology 後期不定 薬学研究科 2018/04-2019/03
創薬有機化学概論 Introduction to Organic Chemistry for Drug Discovery 前期不定 薬学研究科 2018/04-2019/03
リード化合物探索スキル Skill Development for Lead Discovery 通年不定 薬学研究科 2018/04-2019/03
基盤有機化学特論II Advanced Basic Organic Chemistry II 後期不定 薬学研究科 2018/04-2019/03
基礎化学実験 Fundamental Chemical Experiments 後期 全学共通科目 2018/04-2019/03
天然物薬学1(天然物化学) Pharmacognogy 1 (Natural Product Chemistry) 前期 薬学部 2018/04-2019/03
システム生物学・医薬創成系コンテンツ制作 Advanced Methods in Systems Biology & Drug Discovery 後期前期 薬学研究科 2018/04-2019/03
システム生物学・医薬創成系コンテンツ制作 Advanced Methods in Systems Biology & Drug Discovery 通年不定 薬学研究科 2018/04-2019/03
システム生物学・医薬創成系研究 Research in Systems Biology & Drug Dicovery 後期前期 薬学研究科 2018/04-2019/03
システム生物学・医薬創成系研究 Research in Systems Biology & Drug Dicovery 通年不定 薬学研究科 2018/04-2019/03
薬学専門実習2 Pharmaceutical Laboratory 2 : Organic Chemistry 前期 薬学部 2018/04-2019/03

  • <<
  • >>
School management (title, position)
Title Period
ジュニアキャンパス実施検討会 2012/04/01-2014/03/31
京都大学組み換えDNA実験安全委員会 委員 2013/04/01-2015/03/31
ジュニアキャンパス実施検討会 委員 2014/04/01-2016/03/31
ジュニアキャンパス実施検討会 委員 2012/04/01-2016/03/31
組換えDNA実験安全委員会 1号委員 2015/04/01-2017/03/31
Faculty management (title, position)
Title Period
共用試験委員会 委員 2011/04/01-2013/03/31
ホームページ広報委員会 委員 2012/04/01-2014/03/31
ホームページ広報委員会 委員長 2014/04/01-2015/03/31
ホームページ広報委員会 委員 2015/04/01-
学生委員 委員 2013/04/01-2015/03/31
組換えDNA実験安全主任者 2013/04/01-
図書委員会 委員 2011/04/01-
動物実験委員会 委員 2011/04/01-
環境・安全衛生委員会 委員 2011/04/01-
RI管理委員会 委員 2011/04/01-