島村 達郎

Last Update: 2019/06/26 16:15:14

Print

Name(Kanji/Kana/Abecedarium Latinum)
島村 達郎/シマムラ タツロウ/Shimamura, Tatsuro
Primary Affiliation(Org1/Job title)
Graduate Schools Medicine/Program-Specific Senior Lecturer/Program-Specific Junior Associate Professor
Academic Organizations You are Affiliated to in Japan
Organization name(Japanese) Organization name(English)
日本生化学会
日本農芸化学会
日本蛋白質科学会
Academic Degree
Field(Japanese) Field(English) University(Japanese) University(English) Method
修士(農学) 東京大学
博士(農学) 東京大学
researchmap URL
https://researchmap.jp/7000009120
Research Topics
(Japanese)
膜タンパク質の構造生物学
(English)
Structural studies of membrane proteins
Overview of the research
(Japanese)
タンパク質は、生体の多様な機能を支える重要な働きを担っている。このようなタンパク質の機能を理解するには、タンパク質の立体構造情報が必須である。私は、膜タンパク質を主な研究対象とし、その立体構造を解明するとともに、タンパク質の構造変化や、タンパク質を標的とする化合物の探索、相互作用の解明などを目指した研究を行っている。
(English)
Proteins play important roles in various functions of the living cells. The structural information of the proteins is essential for understanding the functions of the proteins. The aims of my research include the elucidations of the 3D structure of membrane proteins and the mechanism of conformational changes of proteins as well as the structure-based design of new ligands.
Fields of research (key words)
Key words(Japanese) Key words(English)
構造生物学 Structural biology
生化学 Biochemistry
分子生物学 Molecular biology
ケミカルバイオロジー Chemical biology
Published Papers
Author Author(Japanese) Author(English) Title Title(Japanese) Title(English) Bibliography Bibliography(Japanese) Bibliography(English) Publication date Refereed paper Language Publishing type Disclose
Kimura KT, Asada H, Inoue A, Kadji FMN, Im D, Mori C, Arakawa T, Hirata K, Nomura Y, Nomura N, Aoki J, Iwata S, Shimamura T Kimura KT, Asada H, Inoue A, Kadji FMN, Im D, Mori C, Arakawa T, Hirata K, Nomura Y, Nomura N, Aoki J, Iwata S, Shimamura T Kimura KT, Asada H, Inoue A, Kadji FMN, Im D, Mori C, Arakawa T, Hirata K, Nomura Y, Nomura N, Aoki J, Iwata S, Shimamura T Structures of the 5-HT<sub>2A</sub> receptor in complex with the antipsychotics risperidone and zotepine. Structures of the 5-HT<sub>2A</sub> receptor in complex with the antipsychotics risperidone and zotepine. Structures of the 5-HT<sub>2A</sub> receptor in complex with the antipsychotics risperidone and zotepine. Nature structural & molecular biology, 26, 2, 121-128 Nature structural & molecular biology, 26, 2, 121-128 Nature structural & molecular biology, 26, 2, 121-128 2019/02 Refereed Disclose to all
Asada H, Horita S, Hirata K, Shiroishi M, Shiimura Y, Iwanari H, Hamakubo T, Shimamura T, Nomura N, Kusano-Arai O, Uemura T, Suno C, Kobayashi T, Iwata S Asada H, Horita S, Hirata K, Shiroishi M, Shiimura Y, Iwanari H, Hamakubo T, Shimamura T, Nomura N, Kusano-Arai O, Uemura T, Suno C, Kobayashi T, Iwata S Asada H, Horita S, Hirata K, Shiroishi M, Shiimura Y, Iwanari H, Hamakubo T, Shimamura T, Nomura N, Kusano-Arai O, Uemura T, Suno C, Kobayashi T, Iwata S Crystal structure of the human angiotensin II type 2 receptor bound to an angiotensin II analog. Crystal structure of the human angiotensin II type 2 receptor bound to an angiotensin II analog. Crystal structure of the human angiotensin II type 2 receptor bound to an angiotensin II analog. Nature structural & molecular biology, 25, 7, 570-576 Nature structural & molecular biology, 25, 7, 570-576 Nature structural & molecular biology, 25, 7, 570-576 2018/07 Refereed Disclose to all
Suno R, Kimura KT, Nakane T, Yamashita K, Wang J, Fujiwara T, Yamanaka Y, Im D, Horita S, Tsujimoto H, Tawaramoto MS, Hirokawa T, Nango E, Tono K, Kameshima T, Hatsui T, Joti Y, Yabashi M, Shimamoto K, Yamamoto M, Rosenbaum DM, Iwata S, Shimamura T, Kobayashi T Suno R, Kimura KT, Nakane T, Yamashita K, Wang J, Fujiwara T, Yamanaka Y, Im D, Horita S, Tsujimoto H, Tawaramoto MS, Hirokawa T, Nango E, Tono K, Kameshima T, Hatsui T, Joti Y, Yabashi M, Shimamoto K, Yamamoto M, Rosenbaum DM, Iwata S, Shimamura T, Kobayashi T Suno R, Kimura KT, Nakane T, Yamashita K, Wang J, Fujiwara T, Yamanaka Y, Im D, Horita S, Tsujimoto H, Tawaramoto MS, Hirokawa T, Nango E, Tono K, Kameshima T, Hatsui T, Joti Y, Yabashi M, Shimamoto K, Yamamoto M, Rosenbaum DM, Iwata S, Shimamura T, Kobayashi T Crystal Structures of Human Orexin 2 Receptor Bound to the Subtype-Selective Antagonist EMPA. Crystal Structures of Human Orexin 2 Receptor Bound to the Subtype-Selective Antagonist EMPA. Crystal Structures of Human Orexin 2 Receptor Bound to the Subtype-Selective Antagonist EMPA. Structure (London, England : 1993), 26, 1, 7-19.e5 Structure (London, England : 1993), 26, 1, 7-19.e5 Structure (London, England : 1993), 26, 1, 7-19.e5 2018/01 Refereed Disclose to all
Nango E, Royant A, Kubo M, Nakane T, Wickstrand C, Kimura T, Tanaka T, Tono K, Song C, Tanaka R, Arima T, Yamashita A, Kobayashi J, Hosaka T, Mizohata E, Nogly P, Sugahara M, Nam D, Nomura T, Shimamura T, Im D, Fujiwara T, Yamanaka Y, Jeon B, Nishizawa T, Oda K, Fukuda M, Andersson R, Båth P, Dods R, Davidsson J, Matsuoka S, Kawatake S, Murata M, Nureki O, Owada S, Kameshima T, Hatsui T, Joti Y, Schertler G, Yabashi M, Bondar AN, Standfuss J, Neutze R, Iwata S Nango E, Royant A, Kubo M, Nakane T, Wickstrand C, Kimura T, Tanaka T, Tono K, Song C, Tanaka R, Arima T, Yamashita A, Kobayashi J, Hosaka T, Mizohata E, Nogly P, Sugahara M, Nam D, Nomura T, Shimamura T, Im D, Fujiwara T, Yamanaka Y, Jeon B, Nishizawa T, Oda K, Fukuda M, Andersson R, Båth P, Dods R, Davidsson J, Matsuoka S, Kawatake S, Murata M, Nureki O, Owada S, Kameshima T, Hatsui T, Joti Y, Schertler G, Yabashi M, Bondar AN, Standfuss J, Neutze R, Iwata S Nango E, Royant A, Kubo M, Nakane T, Wickstrand C, Kimura T, Tanaka T, Tono K, Song C, Tanaka R, Arima T, Yamashita A, Kobayashi J, Hosaka T, Mizohata E, Nogly P, Sugahara M, Nam D, Nomura T, Shimamura T, Im D, Fujiwara T, Yamanaka Y, Jeon B, Nishizawa T, Oda K, Fukuda M, Andersson R, Båth P, Dods R, Davidsson J, Matsuoka S, Kawatake S, Murata M, Nureki O, Owada S, Kameshima T, Hatsui T, Joti Y, Schertler G, Yabashi M, Bondar AN, Standfuss J, Neutze R, Iwata S A three-dimensional movie of structural changes in bacteriorhodopsin. A three-dimensional movie of structural changes in bacteriorhodopsin. A three-dimensional movie of structural changes in bacteriorhodopsin. Science (New York, N.Y.), 354, 6319, 1552-1557 Science (New York, N.Y.), 354, 6319, 1552-1557 Science (New York, N.Y.), 354, 6319, 1552-1557 2016/12 Refereed Disclose to all
Nakane T, Hanashima S, Suzuki M, Saiki H, Hayashi T, Kakinouchi K, Sugiyama S, Kawatake S, Matsuoka S, Matsumori N, Nango E, Kobayashi J, Shimamura T, Kimura K, Mori C, Kunishima N, Sugahara M, Takakyu Y, Inoue S, Masuda T, Hosaka T, Tono K, Joti Y, Kameshima T, Hatsui T, Yabashi M, Inoue T, Nureki O, Iwata S, Murata M, Mizohata E Nakane T, Hanashima S, Suzuki M, Saiki H, Hayashi T, Kakinouchi K, Sugiyama S, Kawatake S, Matsuoka S, Matsumori N, Nango E, Kobayashi J, Shimamura T, Kimura K, Mori C, Kunishima N, Sugahara M, Takakyu Y, Inoue S, Masuda T, Hosaka T, Tono K, Joti Y, Kameshima T, Hatsui T, Yabashi M, Inoue T, Nureki O, Iwata S, Murata M, Mizohata E Nakane T, Hanashima S, Suzuki M, Saiki H, Hayashi T, Kakinouchi K, Sugiyama S, Kawatake S, Matsuoka S, Matsumori N, Nango E, Kobayashi J, Shimamura T, Kimura K, Mori C, Kunishima N, Sugahara M, Takakyu Y, Inoue S, Masuda T, Hosaka T, Tono K, Joti Y, Kameshima T, Hatsui T, Yabashi M, Inoue T, Nureki O, Iwata S, Murata M, Mizohata E Membrane protein structure determination by SAD, SIR, or SIRAS phasing in serial femtosecond crystallography using an iododetergent. Membrane protein structure determination by SAD, SIR, or SIRAS phasing in serial femtosecond crystallography using an iododetergent. Membrane protein structure determination by SAD, SIR, or SIRAS phasing in serial femtosecond crystallography using an iododetergent. Proceedings of the National Academy of Sciences of the United States of America, 113, 46, 13039-13044 Proceedings of the National Academy of Sciences of the United States of America, 113, 46, 13039-13044 Proceedings of the National Academy of Sciences of the United States of America, 113, 46, 13039-13044 2016/11 Refereed Disclose to all
Horita S, Nomura Y, Sato Y, Shimamura T, Iwata S, Nomura N Horita S, Nomura Y, Sato Y, Shimamura T, Iwata S, Nomura N Horita S, Nomura Y, Sato Y, Shimamura T, Iwata S, Nomura N High-resolution crystal structure of the therapeutic antibody pembrolizumab bound to the human PD-1. High-resolution crystal structure of the therapeutic antibody pembrolizumab bound to the human PD-1. High-resolution crystal structure of the therapeutic antibody pembrolizumab bound to the human PD-1. Scientific reports, 6, 35297 Scientific reports, 6, 35297 Scientific reports, 6, 35297 2016/10 Refereed Disclose to all
Kabe Y, Nakane T, Koike I, Yamamoto T, Sugiura Y, Harada E, Sugase K, Shimamura T, Ohmura M, Muraoka K, Yamamoto A, Uchida T, Iwata S, Yamaguchi Y, Krayukhina E, Noda M, Handa H, Ishimori K, Uchiyama S, Kobayashi T, Suematsu M Kabe Y, Nakane T, Koike I, Yamamoto T, Sugiura Y, Harada E, Sugase K, Shimamura T, Ohmura M, Muraoka K, Yamamoto A, Uchida T, Iwata S, Yamaguchi Y, Krayukhina E, Noda M, Handa H, Ishimori K, Uchiyama S, Kobayashi T, Suematsu M Kabe Y, Nakane T, Koike I, Yamamoto T, Sugiura Y, Harada E, Sugase K, Shimamura T, Ohmura M, Muraoka K, Yamamoto A, Uchida T, Iwata S, Yamaguchi Y, Krayukhina E, Noda M, Handa H, Ishimori K, Uchiyama S, Kobayashi T, Suematsu M Haem-dependent dimerization of PGRMC1/Sigma-2 receptor facilitates cancer proliferation and chemoresistance. Haem-dependent dimerization of PGRMC1/Sigma-2 receptor facilitates cancer proliferation and chemoresistance. Haem-dependent dimerization of PGRMC1/Sigma-2 receptor facilitates cancer proliferation and chemoresistance. Nature communications, 7, 11030 Nature communications, 7, 11030 Nature communications, 7, 11030 2016/03 Refereed Disclose to all
Nakane T, Song C, Suzuki M, Nango E, Kobayashi J, Masuda T, Inoue S, Mizohata E, Nakatsu T, Tanaka T, Tanaka R, Shimamura T, Tono K, Joti Y, Kameshima T, Hatsui T, Yabashi M, Nureki O, Iwata S, Sugahara M Nakane T, Song C, Suzuki M, Nango E, Kobayashi J, Masuda T, Inoue S, Mizohata E, Nakatsu T, Tanaka T, Tanaka R, Shimamura T, Tono K, Joti Y, Kameshima T, Hatsui T, Yabashi M, Nureki O, Iwata S, Sugahara M Nakane T, Song C, Suzuki M, Nango E, Kobayashi J, Masuda T, Inoue S, Mizohata E, Nakatsu T, Tanaka T, Tanaka R, Shimamura T, Tono K, Joti Y, Kameshima T, Hatsui T, Yabashi M, Nureki O, Iwata S, Sugahara M Native sulfur/chlorine SAD phasing for serial femtosecond crystallography. Native sulfur/chlorine SAD phasing for serial femtosecond crystallography. Native sulfur/chlorine SAD phasing for serial femtosecond crystallography. Acta crystallographica. Section D, Biological crystallography, 71, Pt 12, 2519-2525 Acta crystallographica. Section D, Biological crystallography, 71, Pt 12, 2519-2525 Acta crystallographica. Section D, Biological crystallography, 71, Pt 12, 2519-2525 2015/12 Refereed Disclose to all
Nomura N, Verdon G, Kang HJ, Shimamura T, Nomura Y, Sonoda Y, Hussien SA, Qureshi AA, Coincon M, Sato Y, Abe H, Nakada-Nakura Y, Hino T, Arakawa T, Kusano-Arai O, Iwanari H, Murata T, Kobayashi T, Hamakubo T, Kasahara M, Iwata S, Drew D Nomura N, Verdon G, Kang HJ, Shimamura T, Nomura Y, Sonoda Y, Hussien SA, Qureshi AA, Coincon M, Sato Y, Abe H, Nakada-Nakura Y, Hino T, Arakawa T, Kusano-Arai O, Iwanari H, Murata T, Kobayashi T, Hamakubo T, Kasahara M, Iwata S, Drew D Nomura N, Verdon G, Kang HJ, Shimamura T, Nomura Y, Sonoda Y, Hussien SA, Qureshi AA, Coincon M, Sato Y, Abe H, Nakada-Nakura Y, Hino T, Arakawa T, Kusano-Arai O, Iwanari H, Murata T, Kobayashi T, Hamakubo T, Kasahara M, Iwata S, Drew D Structure and mechanism of the mammalian fructose transporter GLUT5. Structure and mechanism of the mammalian fructose transporter GLUT5. Structure and mechanism of the mammalian fructose transporter GLUT5. Nature, 526, 7573, 397-401 Nature, 526, 7573, 397-401 Nature, 526, 7573, 397-401 2015/10 Refereed Disclose to all
Tono K, Nango E, Sugahara M, Song C, Park J, Tanaka T, Tanaka R, Joti Y, Kameshima T, Ono S, Hatsui T, Mizohata E, Suzuki M, Shimamura T, Tanaka Y, Iwata S, Yabashi M Tono K, Nango E, Sugahara M, Song C, Park J, Tanaka T, Tanaka R, Joti Y, Kameshima T, Ono S, Hatsui T, Mizohata E, Suzuki M, Shimamura T, Tanaka Y, Iwata S, Yabashi M Tono K, Nango E, Sugahara M, Song C, Park J, Tanaka T, Tanaka R, Joti Y, Kameshima T, Ono S, Hatsui T, Mizohata E, Suzuki M, Shimamura T, Tanaka Y, Iwata S, Yabashi M Diverse application platform for hard X-ray diffraction in SACLA (DAPHNIS): application to serial protein crystallography using an X-ray free-electron laser. Diverse application platform for hard X-ray diffraction in SACLA (DAPHNIS): application to serial protein crystallography using an X-ray free-electron laser. Diverse application platform for hard X-ray diffraction in SACLA (DAPHNIS): application to serial protein crystallography using an X-ray free-electron laser. Journal of synchrotron radiation, 22, Pt 3, 532-537 Journal of synchrotron radiation, 22, Pt 3, 532-537 Journal of synchrotron radiation, 22, Pt 3, 532-537 2015/05 Refereed Disclose to all
Sugahara M, Mizohata E, Nango E, Suzuki M, Tanaka T, Masuda T, Tanaka R, Shimamura T, Tanaka Y, Suno C, Ihara K, Pan D, Kakinouchi K, Sugiyama S, Murata M, Inoue T, Tono K, Song C, Park J, Kameshima T, Hatsui T, Joti Y, Yabashi M, Iwata S Sugahara M, Mizohata E, Nango E, Suzuki M, Tanaka T, Masuda T, Tanaka R, Shimamura T, Tanaka Y, Suno C, Ihara K, Pan D, Kakinouchi K, Sugiyama S, Murata M, Inoue T, Tono K, Song C, Park J, Kameshima T, Hatsui T, Joti Y, Yabashi M, Iwata S Sugahara M, Mizohata E, Nango E, Suzuki M, Tanaka T, Masuda T, Tanaka R, Shimamura T, Tanaka Y, Suno C, Ihara K, Pan D, Kakinouchi K, Sugiyama S, Murata M, Inoue T, Tono K, Song C, Park J, Kameshima T, Hatsui T, Joti Y, Yabashi M, Iwata S Grease matrix as a versatile carrier of proteins for serial crystallography. Grease matrix as a versatile carrier of proteins for serial crystallography. Grease matrix as a versatile carrier of proteins for serial crystallography. Nature methods, 12, 1, 61-63 Nature methods, 12, 1, 61-63 Nature methods, 12, 1, 61-63 2015/01 Refereed Disclose to all
Suharni, Nomura Y, Arakawa T, Hino T, Abe H, Nakada-Nakura Y, Sato Y, Iwanari H, Shiroishi M, Asada H, Shimamura T, Murata T, Kobayashi T, Hamakubo T, Iwata S, Nomura N Suharni, Nomura Y, Arakawa T, Hino T, Abe H, Nakada-Nakura Y, Sato Y, Iwanari H, Shiroishi M, Asada H, Shimamura T, Murata T, Kobayashi T, Hamakubo T, Iwata S, Nomura N Suharni, Nomura Y, Arakawa T, Hino T, Abe H, Nakada-Nakura Y, Sato Y, Iwanari H, Shiroishi M, Asada H, Shimamura T, Murata T, Kobayashi T, Hamakubo T, Iwata S, Nomura N Proteoliposome-based selection of a recombinant antibody fragment against the human M2 muscarinic acetylcholine receptor. Proteoliposome-based selection of a recombinant antibody fragment against the human M2 muscarinic acetylcholine receptor. Proteoliposome-based selection of a recombinant antibody fragment against the human M2 muscarinic acetylcholine receptor. Monoclonal antibodies in immunodiagnosis and immunotherapy, 33, 6, 378-385 Monoclonal antibodies in immunodiagnosis and immunotherapy, 33, 6, 378-385 Monoclonal antibodies in immunodiagnosis and immunotherapy, 33, 6, 378-385 2014/12 Refereed Disclose to all
Koike-Takeshita A, Arakawa T, Taguchi H, Shimamura T Koike-Takeshita A, Arakawa T, Taguchi H, Shimamura T Koike-Takeshita A, Arakawa T, Taguchi H, Shimamura T Crystal Structure of a Symmetric Football-Shaped GroEL:GroES2-ATP14 Complex Determined at 3.8Å Reveals Rearrangement between Two GroEL Rings. Crystal Structure of a Symmetric Football-Shaped GroEL:GroES2-ATP14 Complex Determined at 3.8Å Reveals Rearrangement between Two GroEL Rings. Crystal Structure of a Symmetric Football-Shaped GroEL:GroES2-ATP14 Complex Determined at 3.8Å Reveals Rearrangement between Two GroEL Rings. Journal of molecular biology, 426, 21, 3634-3641 Journal of molecular biology, 426, 21, 3634-3641 Journal of molecular biology, 426, 21, 3634-3641 2014/10 Refereed English Disclose to all
Shimamura T Shimamura T Shimamura T [X-ray structure of histamine H1 receptor]. [X-ray structure of histamine H1 receptor]. [X-ray structure of histamine H1 receptor]. Nihon yakurigaku zasshi. Folia pharmacologica Japonica, 144, 1, 43-44 Nihon yakurigaku zasshi. Folia pharmacologica Japonica, 144, 1, 43-44 Nihon yakurigaku zasshi. Folia pharmacologica Japonica, 144, 1, 43-44 2014/07 Refereed Japanese Disclose to all
Shimamura T, Iwata S Shimamura T, Iwata S Shimamura T, Iwata S [Structural biology and molecular targets]. [Structural biology and molecular targets]. [Structural biology and molecular targets]. Nihon rinsho. Japanese journal of clinical medicine, 70 Suppl 8, 316-320 Nihon rinsho. Japanese journal of clinical medicine, 70 Suppl 8, 316-320 Nihon rinsho. Japanese journal of clinical medicine, 70 Suppl 8, 316-320 2012/11 Refereed Japanese Disclose to all
Shimamura T Shimamura T Shimamura T [Structure of histamine H1 receptor]. [Structure of histamine H1 receptor]. [Structure of histamine H1 receptor]. Seikagaku. The Journal of Japanese Biochemical Society, 84, 9, 772-776 Seikagaku. The Journal of Japanese Biochemical Society, 84, 9, 772-776 Seikagaku. The Journal of Japanese Biochemical Society, 84, 9, 772-776 2012/09 Refereed Japanese Disclose to all
Suno R, Shimoyama M, Abe A, Shimamura T, Shimodate N, Watanabe YH, Akiyama Y, Yoshida M Suno R, Shimoyama M, Abe A, Shimamura T, Shimodate N, Watanabe YH, Akiyama Y, Yoshida M Suno R, Shimoyama M, Abe A, Shimamura T, Shimodate N, Watanabe YH, Akiyama Y, Yoshida M Conformational transition of the lid helix covering the protease active site is essential for the ATP-dependent protease activity of FtsH. Conformational transition of the lid helix covering the protease active site is essential for the ATP-dependent protease activity of FtsH. Conformational transition of the lid helix covering the protease active site is essential for the ATP-dependent protease activity of FtsH. FEBS letters, 586, 19, 3117-3121 FEBS letters, 586, 19, 3117-3121 FEBS letters, 586, 19, 3117-3121 2012/09 Refereed English Disclose to all
Shiroishi M, Tsujimoto H, Makyio H, Asada H, Yurugi-Kobayashi T, Shimamura T, Murata T, Nomura N, Haga T, Iwata S, Kobayashi T Shiroishi M, Tsujimoto H, Makyio H, Asada H, Yurugi-Kobayashi T, Shimamura T, Murata T, Nomura N, Haga T, Iwata S, Kobayashi T Shiroishi M, Tsujimoto H, Makyio H, Asada H, Yurugi-Kobayashi T, Shimamura T, Murata T, Nomura N, Haga T, Iwata S, Kobayashi T Platform for the rapid construction and evaluation of GPCRs for crystallography in Saccharomyces cerevisiae. Platform for the rapid construction and evaluation of GPCRs for crystallography in Saccharomyces cerevisiae. Platform for the rapid construction and evaluation of GPCRs for crystallography in Saccharomyces cerevisiae. Microbial cell factories, 11, 78 Microbial cell factories, 11, 78 Microbial cell factories, 11, 78 2012/06 Refereed English Disclose to all
Hino T, Arakawa T, Iwanari H, Yurugi-Kobayashi T, Ikeda-Suno C, Nakada-Nakura Y, Kusano-Arai O, Weyand S, Shimamura T, Nomura N, Cameron AD, Kobayashi T, Hamakubo T, Iwata S, Murata T Hino T, Arakawa T, Iwanari H, Yurugi-Kobayashi T, Ikeda-Suno C, Nakada-Nakura Y, Kusano-Arai O, Weyand S, Shimamura T, Nomura N, Cameron AD, Kobayashi T, Hamakubo T, Iwata S, Murata T Hino T, Arakawa T, Iwanari H, Yurugi-Kobayashi T, Ikeda-Suno C, Nakada-Nakura Y, Kusano-Arai O, Weyand S, Shimamura T, Nomura N, Cameron AD, Kobayashi T, Hamakubo T, Iwata S, Murata T G-protein-coupled receptor inactivation by an allosteric inverse-agonist antibody. G-protein-coupled receptor inactivation by an allosteric inverse-agonist antibody. G-protein-coupled receptor inactivation by an allosteric inverse-agonist antibody. Nature, 482, 7384, 237-240 Nature, 482, 7384, 237-240 Nature, 482, 7384, 237-240 2012/01 Refereed English Disclose to all
de Graaf C, Kooistra AJ, Vischer HF, Katritch V, Kuijer M, Shiroishi M, Iwata S, Shimamura T, Stevens RC, de Esch IJ, Leurs R de Graaf C, Kooistra AJ, Vischer HF, Katritch V, Kuijer M, Shiroishi M, Iwata S, Shimamura T, Stevens RC, de Esch IJ, Leurs R de Graaf C, Kooistra AJ, Vischer HF, Katritch V, Kuijer M, Shiroishi M, Iwata S, Shimamura T, Stevens RC, de Esch IJ, Leurs R Crystal structure-based virtual screening for fragment-like ligands of the human histamine H(1) receptor. Crystal structure-based virtual screening for fragment-like ligands of the human histamine H(1) receptor. Crystal structure-based virtual screening for fragment-like ligands of the human histamine H(1) receptor. Journal of medicinal chemistry, 54, 23, 8195-8206 Journal of medicinal chemistry, 54, 23, 8195-8206 Journal of medicinal chemistry, 54, 23, 8195-8206 2011/12 Refereed English Disclose to all
Shiroishi M, Kobayashi T, Ogasawara S, Tsujimoto H, Ikeda-Suno C, Iwata S, Shimamura T Shiroishi M, Kobayashi T, Ogasawara S, Tsujimoto H, Ikeda-Suno C, Iwata S, Shimamura T Shiroishi M, Kobayashi T, Ogasawara S, Tsujimoto H, Ikeda-Suno C, Iwata S, Shimamura T Production of the stable human histamine H₁ receptor in Pichia pastoris for structural determination. Production of the stable human histamine H₁ receptor in Pichia pastoris for structural determination. Production of the stable human histamine H₁ receptor in Pichia pastoris for structural determination. Methods (San Diego, Calif.), 55, 4, 281-286 Methods (San Diego, Calif.), 55, 4, 281-286 Methods (San Diego, Calif.), 55, 4, 281-286 2011/12 Refereed English Disclose to all
Tokuda N, Igarashi K, Shimamura T, Yurugi-Kobayashi T, Shiroishi M, Ito K, Sugawara T, Asada H, Murata T, Nomura N, Iwata S, Kobayashi T Tokuda N, Igarashi K, Shimamura T, Yurugi-Kobayashi T, Shiroishi M, Ito K, Sugawara T, Asada H, Murata T, Nomura N, Iwata S, Kobayashi T Tokuda N, Igarashi K, Shimamura T, Yurugi-Kobayashi T, Shiroishi M, Ito K, Sugawara T, Asada H, Murata T, Nomura N, Iwata S, Kobayashi T Cloning, expression and purification of the anion exchanger 1 homologue from the basidiomycete Phanerochaete chrysosporium. Cloning, expression and purification of the anion exchanger 1 homologue from the basidiomycete Phanerochaete chrysosporium. Cloning, expression and purification of the anion exchanger 1 homologue from the basidiomycete Phanerochaete chrysosporium. Protein expression and purification, 79, 1, 81-87 Protein expression and purification, 79, 1, 81-87 Protein expression and purification, 79, 1, 81-87 2011/09 Refereed English Disclose to all
Shimamura T, Shiroishi M, Weyand S, Tsujimoto H, Winter G, Katritch V, Abagyan R, Cherezov V, Liu W, Han GW, Kobayashi T, Stevens RC, Iwata S Shimamura T, Shiroishi M, Weyand S, Tsujimoto H, Winter G, Katritch V, Abagyan R, Cherezov V, Liu W, Han GW, Kobayashi T, Stevens RC, Iwata S Shimamura T, Shiroishi M, Weyand S, Tsujimoto H, Winter G, Katritch V, Abagyan R, Cherezov V, Liu W, Han GW, Kobayashi T, Stevens RC, Iwata S Structure of the human histamine H1 receptor complex with doxepin. Structure of the human histamine H1 receptor complex with doxepin. Structure of the human histamine H1 receptor complex with doxepin. Nature, 475, 7354, 65-70 Nature, 475, 7354, 65-70 Nature, 475, 7354, 65-70 2011/06 Refereed English Disclose to all
Asada H, Uemura T, Yurugi-Kobayashi T, Shiroishi M, Shimamura T, Tsujimoto H, Ito K, Sugawara T, Nakane T, Nomura N, Murata T, Haga T, Iwata S, Kobayashi T Asada H, Uemura T, Yurugi-Kobayashi T, Shiroishi M, Shimamura T, Tsujimoto H, Ito K, Sugawara T, Nakane T, Nomura N, Murata T, Haga T, Iwata S, Kobayashi T Asada H, Uemura T, Yurugi-Kobayashi T, Shiroishi M, Shimamura T, Tsujimoto H, Ito K, Sugawara T, Nakane T, Nomura N, Murata T, Haga T, Iwata S, Kobayashi T Evaluation of the Pichia pastoris expression system for the production of GPCRs for structural analysis. Evaluation of the Pichia pastoris expression system for the production of GPCRs for structural analysis. Evaluation of the Pichia pastoris expression system for the production of GPCRs for structural analysis. Microbial cell factories, 10, 24 Microbial cell factories, 10, 24 Microbial cell factories, 10, 24 2011/04 Refereed English Disclose to all
Ito K, Ito S, Shimamura T, Weyand S, Kawarasaki Y, Misaka T, Abe K, Kobayashi T, Cameron AD, Iwata S Ito K, Ito S, Shimamura T, Weyand S, Kawarasaki Y, Misaka T, Abe K, Kobayashi T, Cameron AD, Iwata S Ito K, Ito S, Shimamura T, Weyand S, Kawarasaki Y, Misaka T, Abe K, Kobayashi T, Cameron AD, Iwata S Crystal structure of glucansucrase from the dental caries pathogen Streptococcus mutans. Crystal structure of glucansucrase from the dental caries pathogen Streptococcus mutans. Crystal structure of glucansucrase from the dental caries pathogen Streptococcus mutans. Journal of molecular biology, 408, 2, 177-186 Journal of molecular biology, 408, 2, 177-186 Journal of molecular biology, 408, 2, 177-186 2011/04 Refereed English Disclose to all
Weyand S, Shimamura T, Beckstein O, Sansom MS, Iwata S, Henderson PJ, Cameron AD Weyand S, Shimamura T, Beckstein O, Sansom MS, Iwata S, Henderson PJ, Cameron AD Weyand S, Shimamura T, Beckstein O, Sansom MS, Iwata S, Henderson PJ, Cameron AD The alternating access mechanism of transport as observed in the sodium-hydantoin transporter Mhp1. The alternating access mechanism of transport as observed in the sodium-hydantoin transporter Mhp1. The alternating access mechanism of transport as observed in the sodium-hydantoin transporter Mhp1. Journal of synchrotron radiation, 18, 1, 20-23 Journal of synchrotron radiation, 18, 1, 20-23 Journal of synchrotron radiation, 18, 1, 20-23 2011/01 Refereed English Disclose to all
Ito K, Sugawara T, Koizumi A, Nakajima K, Shimizu-Ibuka A, Shiroishi M, Asada H, Yurugi-Kobayashi T, Shimamura T, Asakura T, Misaka T, Iwata S, Kobayashi T, Abe K Ito K, Sugawara T, Koizumi A, Nakajima K, Shimizu-Ibuka A, Shiroishi M, Asada H, Yurugi-Kobayashi T, Shimamura T, Asakura T, Misaka T, Iwata S, Kobayashi T, Abe K Ito K, Sugawara T, Koizumi A, Nakajima K, Shimizu-Ibuka A, Shiroishi M, Asada H, Yurugi-Kobayashi T, Shimamura T, Asakura T, Misaka T, Iwata S, Kobayashi T, Abe K Cysteine-to-serine shuffling using a Saccharomyces cerevisiae expression system improves protein secretion: case of a nonglycosylated mutant of miraculin, a taste-modifying protein. Cysteine-to-serine shuffling using a Saccharomyces cerevisiae expression system improves protein secretion: case of a nonglycosylated mutant of miraculin, a taste-modifying protein. Cysteine-to-serine shuffling using a Saccharomyces cerevisiae expression system improves protein secretion: case of a nonglycosylated mutant of miraculin, a taste-modifying protein. Biotechnology letters, 33, 1, 103-107 Biotechnology letters, 33, 1, 103-107 Biotechnology letters, 33, 1, 103-107 2011/01 Refereed English Disclose to all
Ito K, Ito S, Shimamura T, Kawarasaki Y, Abe K, Misaka T, Kobayashi T, Iwata S Ito K, Ito S, Shimamura T, Kawarasaki Y, Abe K, Misaka T, Kobayashi T, Iwata S Ito K, Ito S, Shimamura T, Kawarasaki Y, Abe K, Misaka T, Kobayashi T, Iwata S Crystallization and preliminary X-ray analysis of a glucansucrase from the dental caries pathogen Streptococcus mutans. Crystallization and preliminary X-ray analysis of a glucansucrase from the dental caries pathogen Streptococcus mutans. Crystallization and preliminary X-ray analysis of a glucansucrase from the dental caries pathogen Streptococcus mutans. Acta crystallographica. Section F, Structural biology and crystallization communications, 66, Pt 9, 1086-1088 Acta crystallographica. Section F, Structural biology and crystallization communications, 66, Pt 9, 1086-1088 Acta crystallographica. Section F, Structural biology and crystallization communications, 66, Pt 9, 1086-1088 2010/09 Refereed English Disclose to all
Ito K, Sugawara T, Koizumi A, Nakajima K, Shimizu-Ibuka A, Shiroishi M, Asada H, Yurugi-Kobayashi T, Shimamura T, Asakura T, Masuda K, Ishiguro M, Misaka T, Iwata S, Kobayashi T, Abe K Ito K, Sugawara T, Koizumi A, Nakajima K, Shimizu-Ibuka A, Shiroishi M, Asada H, Yurugi-Kobayashi T, Shimamura T, Asakura T, Masuda K, Ishiguro M, Misaka T, Iwata S, Kobayashi T, Abe K Ito K, Sugawara T, Koizumi A, Nakajima K, Shimizu-Ibuka A, Shiroishi M, Asada H, Yurugi-Kobayashi T, Shimamura T, Asakura T, Masuda K, Ishiguro M, Misaka T, Iwata S, Kobayashi T, Abe K Bulky high-mannose-type N-glycan blocks the taste-modifying activity of miraculin. Bulky high-mannose-type N-glycan blocks the taste-modifying activity of miraculin. Bulky high-mannose-type N-glycan blocks the taste-modifying activity of miraculin. Biochimica et biophysica acta, 1800, 9, 986-992 Biochimica et biophysica acta, 1800, 9, 986-992 Biochimica et biophysica acta, 1800, 9, 986-992 2010/09 Refereed English Disclose to all
Shimamura T, Weyand S, Beckstein O, Rutherford NG, Hadden JM, Sharples D, Sansom MS, Iwata S, Henderson PJ, Cameron AD T. Shimamura; S. Weyand; O. Beckstein; N.G. Rutherford; J.M. Hadden; D. Sharpies; M.S.P. Sansom; S. Iwata; P.J.F. Henderson; A.D. Cameron Shimamura T, Weyand S, Beckstein O, Rutherford NG, Hadden JM, Sharples D, Sansom MS, Iwata S, Henderson PJ, Cameron AD Molecular basis of alternating access membrane transport by the sodium-hydantoin transporter Mhp1. Molecular basis of alternating access membrane transport by the sodium-hydantoin transporter Mhp1 Molecular basis of alternating access membrane transport by the sodium-hydantoin transporter Mhp1. Science (New York, N.Y.), 328, 5977, 470-473 Science, 328, 5977, 470-473 Science (New York, N.Y.), 328, 5977, 470-473 2010/04 Refereed English Disclose to all
Nitanai Y, Shimamura T, Uchiyama T, Ishii Y, Takehira M, Yutani K, Matsuzawa H, Miyano M Nitanai Y, Shimamura T, Uchiyama T, Ishii Y, Takehira M, Yutani K, Matsuzawa H, Miyano M Nitanai Y, Shimamura T, Uchiyama T, Ishii Y, Takehira M, Yutani K, Matsuzawa H, Miyano M The catalytic efficiency (kcat/Km) of the class A beta-lactamase Toho-1 correlates with the thermal stability of its catalytic intermediate analog. The catalytic efficiency (kcat/Km) of the class A beta-lactamase Toho-1 correlates with the thermal stability of its catalytic intermediate analog. The catalytic efficiency (kcat/Km) of the class A beta-lactamase Toho-1 correlates with the thermal stability of its catalytic intermediate analog. Biochimica et biophysica acta, 1804, 4, 684-691 Biochimica et biophysica acta, 1804, 4, 684-691 Biochimica et biophysica acta, 1804, 4, 684-691 2010/04 Refereed English Disclose to all
Sugawara T, Ito K, Shiroishi M, Tokuda N, Asada H, Yurugi-Kobayashi T, Shimamura T, Misaka T, Nomura N, Murata T, Abe K, Iwata S, Kobayashi T Sugawara T, Ito K, Shiroishi M, Tokuda N, Asada H, Yurugi-Kobayashi T, Shimamura T, Misaka T, Nomura N, Murata T, Abe K, Iwata S, Kobayashi T Sugawara T, Ito K, Shiroishi M, Tokuda N, Asada H, Yurugi-Kobayashi T, Shimamura T, Misaka T, Nomura N, Murata T, Abe K, Iwata S, Kobayashi T Fluorescence-based optimization of human bitter taste receptor expression in Saccharomyces cerevisiae. Fluorescence-based optimization of human bitter taste receptor expression in Saccharomyces cerevisiae. Fluorescence-based optimization of human bitter taste receptor expression in Saccharomyces cerevisiae. Biochemical and biophysical research communications, 382, 4, 704-710 Biochemical and biophysical research communications, 382, 4, 704-710 Biochemical and biophysical research communications, 382, 4, 704-710 2009/05 Refereed English Disclose to all
Shimamura T, Nitanai Y, Uchiyama T, Matsuzawa H Shimamura T, Nitanai Y, Uchiyama T, Matsuzawa H Shimamura T, Nitanai Y, Uchiyama T, Matsuzawa H Improvement of crystal quality by surface mutations of beta-lactamase Toho-1. Improvement of crystal quality by surface mutations of beta-lactamase Toho-1. Improvement of crystal quality by surface mutations of beta-lactamase Toho-1. Acta crystallographica. Section F, Structural biology and crystallization communications, 65, Pt 4, 379-382 Acta crystallographica. Section F, Structural biology and crystallization communications, 65, Pt 4, 379-382 Acta crystallographica. Section F, Structural biology and crystallization communications, 65, Pt 4, 379-382 2009/04 Refereed English Disclose to all
Yurugi-Kobayashi T, Asada H, Shiroishi M, Shimamura T, Funamoto S, Katsuta N, Ito K, Sugawara T, Tokuda N, Tsujimoto H, Murata T, Nomura N, Haga K, Haga T, Iwata S, Kobayashi T Yurugi-Kobayashi T, Asada H, Shiroishi M, Shimamura T, Funamoto S, Katsuta N, Ito K, Sugawara T, Tokuda N, Tsujimoto H, Murata T, Nomura N, Haga K, Haga T, Iwata S, Kobayashi T Yurugi-Kobayashi T, Asada H, Shiroishi M, Shimamura T, Funamoto S, Katsuta N, Ito K, Sugawara T, Tokuda N, Tsujimoto H, Murata T, Nomura N, Haga K, Haga T, Iwata S, Kobayashi T Comparison of functional non-glycosylated GPCRs expression in Pichia pastoris. Comparison of functional non-glycosylated GPCRs expression in Pichia pastoris. Comparison of functional non-glycosylated GPCRs expression in Pichia pastoris. Biochemical and biophysical research communications, 380, 2, 271-276 Biochemical and biophysical research communications, 380, 2, 271-276 Biochemical and biophysical research communications, 380, 2, 271-276 2009/03 Refereed English Disclose to all
T. Shimamura; S. Yajima; S. Suzuki; N.G. Rutherford; J. O'Reilly; P.J.F. Henderson; S. Iwata Shimamura T, Yajima S, Suzuki S, Rutherford NG, O'Reilly J, Henderson PJ, Iwata S T. Shimamura; S. Yajima; S. Suzuki; N.G. Rutherford; J. O'Reilly; P.J.F. Henderson; S. Iwata Crystallization of the hydantoin transporter Mhp1 from Microbacterium liquefaciens Crystallization of the hydantoin transporter Mhp1 from Microbacterium liquefaciens. Crystallization of the hydantoin transporter Mhp1 from Microbacterium liquefaciens Acta Crystallographica Section F: Structural Biology and Crystallization Communications, 64, Pt 12, 1172-1174 Acta crystallographica. Section F, Structural biology and crystallization communications, 64, Pt 12, 1172-1174 Acta Crystallographica Section F: Structural Biology and Crystallization Communications, 64, Pt 12, 1172-1174 2008/12 Refereed English Disclose to all
Weyand S, Shimamura T, Yajima S, Suzuki S, Mirza O, Krusong K, Carpenter EP, Rutherford NG, Hadden JM, O'Reilly J, Ma P, Saidijam M, Patching SG, Hope RJ, Norbertczak HT, Roach PC, Iwata S, Henderson PJ, Cameron AD S. Weyand; T. Shimamura; S. Yajima; S. Suzuki; O. Mirza; K. Krusong; E.P. Carpenter; N.G. Rutherford; J.M. Hadden; J. O'Reilly; P. Ma; M. Saidijam; S.G. Patching; R.J. Hope; H.T. Norbertczak; P.C.J. Roach; S. Iwata; P.J.F. Henderson; A.D. Cameron Weyand S, Shimamura T, Yajima S, Suzuki S, Mirza O, Krusong K, Carpenter EP, Rutherford NG, Hadden JM, O'Reilly J, Ma P, Saidijam M, Patching SG, Hope RJ, Norbertczak HT, Roach PC, Iwata S, Henderson PJ, Cameron AD Structure and molecular mechanism of a nucleobase-cation-symport-1 family transporter. Structure and molecular mechanism of a nucleobase-cation-symport-1 family transporter Structure and molecular mechanism of a nucleobase-cation-symport-1 family transporter. Science (New York, N.Y.), 322, 5902, 709-713 Science, 322, 5902, 709-713 Science (New York, N.Y.), 322, 5902, 709-713 2008/10 Refereed English Disclose to all
M. Jormakka; K. Yokoyama; T. Yano; M. Tamakoshi; S. Akimoto; T. Shimamura; P. Curmi; S. Iwata Jormakka M, Yokoyama K, Yano T, Tamakoshi M, Akimoto S, Shimamura T, Curmi P, Iwata S M. Jormakka; K. Yokoyama; T. Yano; M. Tamakoshi; S. Akimoto; T. Shimamura; P. Curmi; S. Iwata Molecular mechanism of energy conservation in polysulfide respiration Molecular mechanism of energy conservation in polysulfide respiration. Molecular mechanism of energy conservation in polysulfide respiration Nature Structural and Molecular Biology, 15, 7, 730-737 Nature structural & molecular biology, 15, 7, 730-737 Nature Structural and Molecular Biology, 15, 7, 730-737 2008/07 Refereed English Disclose to all
K. Ito; T. Sugawara; M. Shiroishi; N. Tokuda; A. Kurokawa; T. Misaka; H. Makyio; T. Yurugi-Kobayashi; T. Shimamura; N. Nomura; T. Murata; K. Abe; S. Iwata; T. Kobayashi Ito K, Sugawara T, Shiroishi M, Tokuda N, Kurokawa A, Misaka T, Makyio H, Yurugi-Kobayashi T, Shimamura T, Nomura N, Murata T, Abe K, Iwata S, Kobayashi T K. Ito; T. Sugawara; M. Shiroishi; N. Tokuda; A. Kurokawa; T. Misaka; H. Makyio; T. Yurugi-Kobayashi; T. Shimamura; N. Nomura; T. Murata; K. Abe; S. Iwata; T. Kobayashi Advanced method for high-throughput expression of mutated eukaryotic membrane proteins in Saccharomyces cerevisiae Advanced method for high-throughput expression of mutated eukaryotic membrane proteins in Saccharomyces cerevisiae. Advanced method for high-throughput expression of mutated eukaryotic membrane proteins in Saccharomyces cerevisiae Biochemical and Biophysical Research Communications, 371, 4, 841-845 Biochemical and biophysical research communications, 371, 4, 841-845 Biochemical and Biophysical Research Communications, 371, 4, 841-845 2008/07 Refereed English Disclose to all
T. Shimamura; K. Hiraki; N. Takahashi; T. Hori; H. Ago; K. Masuda; K. Takio; M. Ishiguro; M. Miyano Shimamura T, Hiraki K, Takahashi N, Hori T, Ago H, Masuda K, Takio K, Ishiguro M, Miyano M T. Shimamura; K. Hiraki; N. Takahashi; T. Hori; H. Ago; K. Masuda; K. Takio; M. Ishiguro; M. Miyano Crystal structure of squid rhodopsin with intracellularly extended cytoplasmic region Crystal structure of squid rhodopsin with intracellularly extended cytoplasmic region. Crystal structure of squid rhodopsin with intracellularly extended cytoplasmic region Journal of Biological Chemistry, 283, 26, 17753-17756 The Journal of biological chemistry, 283, 26, 17753-17756 Journal of Biological Chemistry, 283, 26, 17753-17756 2008/06 Refereed English Disclose to all
H. Ago; Y. Kanaoka; D. Irikura; B.K. Lam; T. Shimamura; K.F. Austen; M. Miyano Ago H, Kanaoka Y, Irikura D, Lam BK, Shimamura T, Austen KF, Miyano M H. Ago; Y. Kanaoka; D. Irikura; B.K. Lam; T. Shimamura; K.F. Austen; M. Miyano Crystal structure of a human membrane protein involved in cysteinyl leukotriene biosynthesis Crystal structure of a human membrane protein involved in cysteinyl leukotriene biosynthesis. Crystal structure of a human membrane protein involved in cysteinyl leukotriene biosynthesis Nature, 448, 7153, 609-612 Nature, 448, 7153, 609-612 Nature, 448, 7153, 609-612 2007/08 Refereed English Disclose to all
H. Nakayama; T. Shimamura; T. Imagawa; N. Shirai; T. Itoh; Y. Sako; M. Miyano; H. Sakuraba; T. Ohshima; N. Nomura; H. Tsuge Nakayama H, Shimamura T, Imagawa T, Shirai N, Itoh T, Sako Y, Miyano M, Sakuraba H, Ohshima T, Nomura N, Tsuge H H. Nakayama; T. Shimamura; T. Imagawa; N. Shirai; T. Itoh; Y. Sako; M. Miyano; H. Sakuraba; T. Ohshima; N. Nomura; H. Tsuge Structure of a Hyperthermophilic Archaeal Homing Endonuclease, I-Tsp061I: Contribution of Cross-domain Polar Networks to Thermostability Structure of a hyperthermophilic archaeal homing endonuclease, I-Tsp061I: contribution of cross-domain polar networks to thermostability. Structure of a Hyperthermophilic Archaeal Homing Endonuclease, I-Tsp061I: Contribution of Cross-domain Polar Networks to Thermostability Journal of Molecular Biology, 365, 2, 362-378 Journal of molecular biology, 365, 2, 362-378 Journal of Molecular Biology, 365, 2, 362-378 2007/01 Refereed English Disclose to all
A. Koike-Takeshita; T. Shimamura; K. Yokoyama; M. Yoshida; H. Taguchi Koike-Takeshita A, Shimamura T, Yokoyama K, Yoshida M, Taguchi H A. Koike-Takeshita; T. Shimamura; K. Yokoyama; M. Yoshida; H. Taguchi Leu<sup>309</sup> plays a critical role in the encapsulation of substrate protein into the internal cavity of GroEL Leu309 plays a critical role in the encapsulation of substrate protein into the internal cavity of GroEL. Leu<sup>309</sup> plays a critical role in the encapsulation of substrate protein into the internal cavity of GroEL Journal of Biological Chemistry, 281, 2, 962-967 The Journal of biological chemistry, 281, 2, 962-967 Journal of Biological Chemistry, 281, 2, 962-967 2006/01 Refereed English Disclose to all
T. Shimamura; A. Koike-Takeshita; K. Yokoyama; R. Masui; N. Murai; M. Yoshida; H. Taguchi; S. Iwata Shimamura T, Koike-Takeshita A, Yokoyama K, Masui R, Murai N, Yoshida M, Taguchi H, Iwata S T. Shimamura; A. Koike-Takeshita; K. Yokoyama; R. Masui; N. Murai; M. Yoshida; H. Taguchi; S. Iwata Crystal structure of the native chaperonin complex from Thermus thermophilus revealed unexpected asymmetry at the cis-cavity Crystal structure of the native chaperonin complex from Thermus thermophilus revealed unexpected asymmetry at the cis-cavity. Crystal structure of the native chaperonin complex from Thermus thermophilus revealed unexpected asymmetry at the cis-cavity Structure, 12, 8, 1471-1480 Structure (London, England : 1993), 12, 8, 1471-1480 Structure, 12, 8, 1471-1480 2004/08 Refereed English Disclose to all
T. Shimamura; O. Shamotienko; S. Akhtar; J.O. Dolly; S. Iwata Shimamura T, Shamotienko O, Akhtar S, Dolly JO, Iwata S T. Shimamura; O. Shamotienko; S. Akhtar; J.O. Dolly; S. Iwata Crystallization and preliminary X-ray analysis of pseudo-merohedrally twinned crystals of the full-length β<sub>2</sub> subunit of the Kv1 K <sup>+</sup> channel from Rattus norvegicus Crystallization and preliminary X-ray analysis of pseudo-merohedrally twinned crystals of the full-length beta(2) subunit of the Kv1 K(+) channel from Rattus norvegicus. Crystallization and preliminary X-ray analysis of pseudo-merohedrally twinned crystals of the full-length β<sub>2</sub> subunit of the Kv1 K <sup>+</sup> channel from Rattus norvegicus Acta Crystallographica Section D: Biological Crystallography, 60, Pt 5, 912-914 Acta crystallographica. Section D, Biological crystallography, 60, Pt 5, 912-914 Acta Crystallographica Section D: Biological Crystallography, 60, Pt 5, 912-914 2004/05 Refereed English Disclose to all
T. Shimamura; A. Koike-Takeshita; K. Yokoyama; M. Yoshida; H. Taguchi; S. Iwata Shimamura T, Koike-Takeshita A, Yokoyama K, Yoshida M, Taguchi H, Iwata S T. Shimamura; A. Koike-Takeshita; K. Yokoyama; M. Yoshida; H. Taguchi; S. Iwata Crystallization of the chaperonin GroEL-GroES complex from Thermus thermophilus HB8 Crystallization of the chaperonin GroEL-GroES complex from Thermus thermophilus HB8. Crystallization of the chaperonin GroEL-GroES complex from Thermus thermophilus HB8 Acta Crystallographica - Section D Biological Crystallography, 59, Pt 9, 1632-1634 Acta crystallographica. Section D, Biological crystallography, 59, Pt 9, 1632-1634 Acta Crystallographica - Section D Biological Crystallography, 59, Pt 9, 1632-1634 2003/09 Refereed English Disclose to all
T. Shimamura; A. Ibuka; S. Fushinobu; T. Wakagi; M. Ishiguro; Y. Ishii; H. Matsuzaw Shimamura T, Ibuka A, Fushinobu S, Wakagi T, Ishiguro M, Ishii Y, Matsuzawa H T. Shimamura; A. Ibuka; S. Fushinobu; T. Wakagi; M. Ishiguro; Y. Ishii; H. Matsuzaw Acyl-intermediate structures of the extended-spectrum class A β-lactamase, Toho-1, in complex with cefotaxime, cephalothin, and benzylpenicillin Acyl-intermediate structures of the extended-spectrum class A beta-lactamase, Toho-1, in complex with cefotaxime, cephalothin, and benzylpenicillin. Acyl-intermediate structures of the extended-spectrum class A β-lactamase, Toho-1, in complex with cefotaxime, cephalothin, and benzylpenicillin Journal of Biological Chemistry, 277, 48, 46601-46608 The Journal of biological chemistry, 277, 48, 46601-46608 Journal of Biological Chemistry, 277, 48, 46601-46608 2002/11 Refereed English Disclose to all

  • <<
  • >>
Title language:
Conference Activities & Talks
Title Title(Japanese) Title(English) Conference Conference(Japanese) Conference(English) Promotor Promotor(Japanese) Promotor(English) Date Language Assortment Disclose
Serial Femtosecond crystallography using LCP crystals at SACLA[Invited] Serial Femtosecond crystallography using LCP crystals at SACLA [Invited] Serial Femtosecond crystallography using LCP crystals at SACLA [Invited] AsCA 2018/CRYSTAL 32 AsCA 2018/CRYSTAL 32 AsCA 2018/CRYSTAL 32 The Asian Crystallographic Association The Asian Crystallographic Association The Asian Crystallographic Association 2018/12/02 English Symposium workshop panel(nominated) Disclose to all
Structure of the human histamine H1 receptor with doxepin.[Invited] Structure of the human histamine H1 receptor with doxepin. [Invited] Structure of the human histamine H1 receptor with doxepin. [Invited] International Union of Crystallography, XXII Congress and General Assembly. International Union of Crystallography, XXII Congress and General Assembly. International Union of Crystallography, XXII Congress and General Assembly. International Union of Crystallography International Union of Crystallography 2011/08/29 English Oral presentation(invited, special) Disclose to all
Title language:
Patents
Inventor(s) Inventor(s) (Japanese) Inventor(s) (English) Title Title(Japanese) Title(English) Stage Patent number Date Disclose
小笠原 諭, 日野 智也, 島村 達郎, 荒川 孝俊, 万木 貴美, 寿野 千代, 村田 武士, 小林 拓也, 岩田 想 小笠原 諭, 日野 智也, 島村 達郎, 荒川 孝俊, 万木 貴美, 寿野 千代, 村田 武士, 小林 拓也, 岩田 想 アゴニストの親和性を亢進する抗ヒトアデノシンA2a受容体モノクローナル抗体 アゴニストの親和性を亢進する抗ヒトアデノシンA2a受容体モノクローナル抗体 特許登録 特許第5750700号 2015/05/29 Disclose to all
小笠原 諭, 日野 智也, 島村 達郎, 荒川 孝俊, 万木 貴美, 寿野 千代, 村田 武士, 小林 拓也, 岩田 想 小笠原 諭, 日野 智也, 島村 達郎, 荒川 孝俊, 万木 貴美, 寿野 千代, 村田 武士, 小林 拓也, 岩田 想 アゴニストの親和性を亢進する抗ヒトアデノシンA2a受容体モノクローナル抗体 アゴニストの親和性を亢進する抗ヒトアデノシンA2a受容体モノクローナル抗体 特許公開 特開2013-183660 2013/09/19 Disclose to all
Title language:
External funds: competitive funds and Grants-in-Aid for Scientific Research (Kakenhi)
Type Position Title(Japanese) Title(English) Period
基盤研究(B) Representative X線結晶構造解析による核酸塩基ー陽イオン共輸送体の輸送機構の解明 2009/04/01-2012/03/31
新学術領域研究(研究領域提案型) Representative アロステリック抗体を用いたアデノシン受容体の構造解析 2012/04/01-2014/03/31
基盤研究(B) Representative 次世代抗ヒスタミン薬の開発に役立つヒスタミン受容体の構造解析           2012/04/01-2015/03/31
挑戦的萌芽研究 Representative ヒト由来膜輸送体の結晶構造解析への挑戦 2013-2014
挑戦的萌芽研究 Representative ヒト由来膜輸送体の結晶構造解析への挑戦 (平成26年度分) 2014/04/01-2015/03/31
新学術領域研究(研究領域提案型) Representative 立体構造に基づくGPCRとリガンドの相互作用の解明 (平成26年度分) 2014/04/01-2015/03/31
基盤研究(B) Representative G蛋白質非依存的な情報伝達を行い、抗癌剤の標的であるケモカイン受容体の構造解析 (平成27年度分) 2015/04/01-2016/03/31
新学術領域研究(研究領域提案型) Representative 立体構造に基づくGPCRとリガンドの相互作用の解明 (平成27年度分) 2015/04/01-2016/03/31
基盤研究(B) Representative G蛋白質非依存的な情報伝達を行い、抗癌剤の標的であるケモカイン受容体の構造解析 (平成28年度分) 2016/04/01-2017/03/31
挑戦的研究(萌芽) Representative 分子量の小さいGPCRのクライオ電子顕微鏡を用いた単粒子解析の挑戦 (平成29年度分) 2017/04/01-2018/03/31
基盤研究(B) Representative G蛋白質非依存的な情報伝達を行い、抗癌剤の標的であるケモカイン受容体の構造解析 (平成29年度分) 2017/04/01-2018/03/31
挑戦的研究(萌芽) Representative 分子量の小さいGPCRのクライオ電子顕微鏡を用いた単粒子解析の挑戦 (平成30年度分) 2018/04/01-2019/03/31
基盤研究(B) Representative GPCRのバイアス型シグナル機構の構造基盤 (平成30年度分) 2018/04/01-2019/03/31

  • <<
  • >>
Teaching subject(s)
Name(Japanese) Name(English) Term Department Period
タンパク質のかたちを観る/生命現象を観る Direct observation of the protein shape and life phenomenon 前期 全学共通科目 2012/04-2013/03