笹井 蘭

Last Update: 2019/06/13 19:24:55

Print

Name(Kanji/Kana/Abecedarium Latinum)
笹井 蘭/ササイ ラン/Sasai, Ran
Primary Affiliation(Org1/Job title)
Kyoto University Hospital/Assistant Professor
Academic Organizations You are Affiliated to in Japan
Organization name(Japanese) Organization name(English)
日本内科学会 The Japanese Society of Internal Medicine
日本リウマチ学会 Japan College of Rheumatology
日本臨床免疫学会 The Japan Society of Clinical Immunology
日本免疫学会 Japanese Society for Immunology
日本炎症・再生学会
Academic Degree
Field(Japanese) Field(English) University(Japanese) University(English) Method
博士(医学) 京都大学
Graduate School
University(Japanese) University(English) Faculty(Japanese) Faculty(English) Major(Japanese) Major(English) Degree
京都大学 大学院医学研究科博士課程内科系専攻 修了
Undergraduate School / Major(s)
University(Japanese) University(English) Faculty(Japanese) Faculty(English) Major(s)(Japanese) Major(s)(English) Degree
京都大学 医学部医学科 卒業
researchmap URL
https://researchmap.jp/7000008099
Research Topics
(Japanese)
多発性筋炎・皮膚筋炎に伴う自己抗体と対応抗原の検索 抗MDA5抗体陽性皮膚筋炎の病態の解明と治療法の探究
(English)
Investigation of new myositis-specific autoantibodies and autoantigens Investigation of pathophisiology and therapeutic strategy in anti-MDA5-positive dermatomyositis
Overview of the research
(Japanese)
抗MDA5抗体陽性皮膚筋炎は、多発性筋炎/皮膚筋炎(PM/DM)の中でも最も予後不良な一群であり、特に急速進行性間質性肺炎を合併するリスクが高い。しかし治療は未だ確立していない。本疾患の病態には単球やマクロファージの活性化が示唆されているが未だ明らかではなく、本疾患症例の末梢血・病変組織中に存在するリンパ球分画やサイトカイン・ケモカイン関連分子の発現を検討し、病態解明と新規治療法開発を探求している。
(English)
Anti-MDA5 is associated with rapidly progressive interstitial lung disease and one of the most important prognostic factor in PM/DM patients. However, therapeutic strategy for the disease have not been established. In anti-MDA5-positive DM, excessive activation of monocyte or macrophage has been suggested, but it remains to be proved. We investigate the lymphocyte fraction and expression of molecules which are associated with cytokines and chemokines to elucidate the pathophysiology and therapeutic strategy in anti-MDA5-positive DM with ILD.
Fields of research (key words)
Key words(Japanese) Key words(English)
自己免疫 autoimmune
膠原病 connective tissue disease
多発性筋炎/皮膚筋炎 polymyositis/dermatomyositis
自己抗体 autoantibody
間質性肺炎 interstitial pneumonia
External funds: competitive funds and Grants-in-Aid for Scientific Research (Kakenhi)
Type Position Title(Japanese) Title(English) Period
若手研究(B) Representative 抗MDA5抗体陽性皮膚筋炎の病因・病態解明 (平成26年度分) 2014/04/01-2015/03/31
若手研究(B) Representative 抗MDA5抗体陽性皮膚筋炎の病因・病態解明 (平成27年度分) 2015/04/01-2016/03/31