志村 和也

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Name(Kanji/Kana/Abecedarium Latinum)
志村 和也/シムラ カズヤ/Shimura, Kazuya
Primary Affiliation(Org1/Job title)
Institute for Frontier Life and Medical Sciences/Assistant Professor
Affiliated programs (koza)
Org1 Job title
Graduate Schools Medicine Assistant Professor
E-mail Address
shimura.kazuya.4w @ kyoto-u.ac.jp
E-mail Address
E-mail address
kshimura @ infront.kyoto-u.ac.jp
Academic Degree
Field(Japanese) Field(English) University(Japanese) University(English) Method
修士(薬学) 昭和薬科大学
博士(医学) 京都大学
Personal Profile
(Japanese)
後天性免疫不全症候群(エイズ)の原因ウイルスであるHIVに関する研究をしています。
ORCID ID
https://orcid.org/0000-0001-7819-5184
researchmap URL
https://researchmap.jp/read0201537
Research Topics
(Japanese)
ヒト免疫不全ウイルスに対する新規阻害剤の開発と耐性機序の解析
(English)
Development of novel antiviral drugs and analysis of HIV-1 drug resistance mechanisms
Overview of the research
(Japanese)
ヒト免疫不全ウイルス(human immunodeficiency virus: HIV)感染症は、CD4陽性Tリンパ球の減少による免疫不全状態を惹起し、後天性免疫不全症候群(acquired immunodeficiency syndrome: AIDS)を引き起こす。当初は不治の病として恐れられたAIDSも、近年では多くの抗HIV薬の開発や、それらを組み合わせた治療法の確立により、制御可能な慢性疾患へと変貌した。しかしながらウイルスの複製を検出限界以下に抑え続けるためには終生にわたる服用が不可欠であるため、それに付随する耐性ウイルスや副作用などへの対応が重要になっている。 我々は、薬剤耐性HIVにも効果を示す新規抗ウイルス薬の開発研究を進めており、作用機序解析や耐性化機構の解明なども行っている。
(English)
Recent anti-retroviral therapy potently suppresses HIV-1 replication, and improves prognosis of HIV-1 infected individuals. However, long-term antiviral therapies induce drug resistant viruses, and this is a major obstacle of efficient therapies. In order to develop new small-molecule anti-HIV drugs, we screened tens of thousands of compounds and several with anti-HIV activity were identified. Among them, some compounds seem to inhibit HIV replication by a novel mode of action. We are going to identify the mechanism of action and reveal antiviral spectrum. In addition, complete eradication of HIV has not yet been achieved due to the presence of latently infected cells. In order to gain deeper insight into their importance, we are analyzing the property of the reservoir cells.
Fields of research (key words)
Key words(Japanese) Key words(English)
ウイルス感染症 Viral infection
抗ウイルス剤 Antivirals
薬剤耐性 Drug resistance
Published Papers
Author Author(Japanese) Author(English) Title Title(Japanese) Title(English) Bibliography Bibliography(Japanese) Bibliography(English) Publication date Refereed paper Language Publishing type Disclose
Mahgoub M, Yasunaga JI, Iwami S, Nakaoka S, Koizumi Y, Shimura K, Matsuoka M Mahgoub M, Yasunaga JI, Iwami S, Nakaoka S, Koizumi Y, Shimura K, Matsuoka M Mahgoub M, Yasunaga JI, Iwami S, Nakaoka S, Koizumi Y, Shimura K, Matsuoka M Sporadic on/off switching of HTLV-1 Tax expression is crucial to maintain the whole population of virus-induced leukemic cells. Sporadic on/off switching of HTLV-1 Tax expression is crucial to maintain the whole population of virus-induced leukemic cells. Sporadic on/off switching of HTLV-1 Tax expression is crucial to maintain the whole population of virus-induced leukemic cells. Proceedings of the National Academy of Sciences of the United States of America, 115, 6, E1269-E1278 Proceedings of the National Academy of Sciences of the United States of America, 115, 6, E1269-E1278 Proceedings of the National Academy of Sciences of the United States of America, 115, 6, E1269-E1278 2018/02 Refereed Disclose to all
Kinosada H, Yasunaga JI, Shimura K, Miyazato P, Onishi C, Iyoda T, Inaba K, Matsuoka M Kinosada H, Yasunaga JI, Shimura K, Miyazato P, Onishi C, Iyoda T, Inaba K, Matsuoka M Kinosada H, Yasunaga JI, Shimura K, Miyazato P, Onishi C, Iyoda T, Inaba K, Matsuoka M Correction: HTLV-1 bZIP Factor Enhances T-cell Proliferation by Impeding the Suppressive Signaling of Co-inhibitory Receptors. Correction: HTLV-1 bZIP Factor Enhances T-cell Proliferation by Impeding the Suppressive Signaling of Co-inhibitory Receptors. Correction: HTLV-1 bZIP Factor Enhances T-cell Proliferation by Impeding the Suppressive Signaling of Co-inhibitory Receptors. PLoS pathogens, 13, 2, e1006228 PLoS pathogens, 13, 2, e1006228 PLoS pathogens, 13, 2, e1006228 2017/02 Refereed Disclose to all
Kinosada H, Yasunaga JI, Shimura K, Miyazato P, Onishi C, Iyoda T, Inaba K, Matsuoka M Kinosada H, Yasunaga JI, Shimura K, Miyazato P, Onishi C, Iyoda T, Inaba K, Matsuoka M Kinosada H, Yasunaga JI, Shimura K, Miyazato P, Onishi C, Iyoda T, Inaba K, Matsuoka M HTLV-1 bZIP Factor Enhances T-Cell Proliferation by Impeding the Suppressive Signaling of Co-inhibitory Receptors. HTLV-1 bZIP Factor Enhances T-Cell Proliferation by Impeding the Suppressive Signaling of Co-inhibitory Receptors. HTLV-1 bZIP Factor Enhances T-Cell Proliferation by Impeding the Suppressive Signaling of Co-inhibitory Receptors. PLoS pathogens, 13, 1, e1006120 PLoS pathogens, 13, 1, e1006120 PLoS pathogens, 13, 1, e1006120 2017/01 Refereed Disclose to all
Alam M, Kuwata T, Shimura K, Yokoyama M, Ramirez Valdez KP, Tanaka K, Maruta Y, Oishi S, Fujii N, Sato H, Matsuoka M, Matsushita S Alam M, Kuwata T, Shimura K, Yokoyama M, Ramirez Valdez KP, Tanaka K, Maruta Y, Oishi S, Fujii N, Sato H, Matsuoka M, Matsushita S Alam M, Kuwata T, Shimura K, Yokoyama M, Ramirez Valdez KP, Tanaka K, Maruta Y, Oishi S, Fujii N, Sato H, Matsuoka M, Matsushita S Enhanced antibody-mediated neutralization of HIV-1 variants that are resistant to fusion inhibitors. Enhanced antibody-mediated neutralization of HIV-1 variants that are resistant to fusion inhibitors. Enhanced antibody-mediated neutralization of HIV-1 variants that are resistant to fusion inhibitors. Retrovirology, 13, 1, 70 Retrovirology, 13, 1, 70 Retrovirology, 13, 1, 70 2016/09 Refereed Disclose to all
K. Shimura; P. Miyazato; S. Oishi; N. Fujii; M. Matsuoka Shimura K, Miyazato P, Oishi S, Fujii N, Matsuoka M K. Shimura; P. Miyazato; S. Oishi; N. Fujii; M. Matsuoka Impact of HIV-1 infection pathways on susceptibility to antiviral drugs and on virus spread Impact of HIV-1 infection pathways on susceptibility to antiviral drugs and on virus spread. Impact of HIV-1 infection pathways on susceptibility to antiviral drugs and on virus spread Virology, 484, 364-376 Virology, 484, 364-376 Virology, 484, 364-376 2015/07 Refereed Disclose to all
Okazaki S, Oishi S, Mizuhara T, Shimura K, Murayama H, Ohno H, Matsuoka M, Fujii N Okazaki S, Oishi S, Mizuhara T, Shimura K, Murayama H, Ohno H, Matsuoka M, Fujii N Okazaki S, Oishi S, Mizuhara T, Shimura K, Murayama H, Ohno H, Matsuoka M, Fujii N Investigations of possible prodrug structures for 2-(2-mercaptophenyl)tetrahydropyrimidines: reductive conversion from anti-HIV agents with pyrimidobenzothiazine and isothiazolopyrimidine scaffolds. Investigations of possible prodrug structures for 2-(2-mercaptophenyl)tetrahydropyrimidines: reductive conversion from anti-HIV agents with pyrimidobenzothiazine and isothiazolopyrimidine scaffolds. Investigations of possible prodrug structures for 2-(2-mercaptophenyl)tetrahydropyrimidines: reductive conversion from anti-HIV agents with pyrimidobenzothiazine and isothiazolopyrimidine scaffolds. Organic & biomolecular chemistry, 13, 16, 4706-4713 Organic & biomolecular chemistry, 13, 16, 4706-4713 Organic & biomolecular chemistry, 13, 16, 4706-4713 2015/04 Refereed Disclose to all
Okazaki S, Mizuhara T, Shimura K, Murayama H, Ohno H, Oishi S, Matsuoka M, Fujii N Okazaki S, Mizuhara T, Shimura K, Murayama H, Ohno H, Oishi S, Matsuoka M, Fujii N Okazaki S, Mizuhara T, Shimura K, Murayama H, Ohno H, Oishi S, Matsuoka M, Fujii N Identification of anti-HIV agents with a novel benzo[4,5]isothiazolo[2,3-a]pyrimidine scaffold. Identification of anti-HIV agents with a novel benzo[4,5]isothiazolo[2,3-a]pyrimidine scaffold. Identification of anti-HIV agents with a novel benzo[4,5]isothiazolo[2,3-a]pyrimidine scaffold. Bioorganic & medicinal chemistry, 23, 7, 1447-1452 Bioorganic & medicinal chemistry, 23, 7, 1447-1452 Bioorganic & medicinal chemistry, 23, 7, 1447-1452 2015/04 Refereed Disclose to all
T. Mizuhara; T. Kato; A. Hirai; H. Kurihara; Y. Shimada; M. Taniguchi; H. Maeta; H. Togami; K. Shimura; M. Matsuoka; S. Okazaki; T. Takeuchi; H. Ohno; S. Oishi; N. Fujii Mizuhara T, Kato T, Hirai A, Kurihara H, Shimada Y, Taniguchi M, Maeta H, Togami H, Shimura K, Matsuoka M, Okazaki S, Takeuchi T, Ohno H, Oishi S, Fujii N T. Mizuhara; T. Kato; A. Hirai; H. Kurihara; Y. Shimada; M. Taniguchi; H. Maeta; H. Togami; K. Shimura; M. Matsuoka; S. Okazaki; T. Takeuchi; H. Ohno; S. Oishi; N. Fujii Structure-activity relationship study of phenylpyrazole derivatives as a novel class of anti-HIV agents Structure-activity relationship study of phenylpyrazole derivatives as a novel class of anti-HIV agents. Structure-activity relationship study of phenylpyrazole derivatives as a novel class of anti-HIV agents Bioorganic and Medicinal Chemistry Letters, 23, 16, 4557-4561 Bioorganic & medicinal chemistry letters, 23, 16, 4557-4561 Bioorganic and Medicinal Chemistry Letters, 23, 16, 4557-4561 2013/08 Refereed English Disclose to all
K. Shimane; K. Kawaji; F. Miyamoto; S. Oishi; K. Watanabe; Y. Sakagami; N. Fujii; K. Shimura; M. Matsuoka; M. Kaku; S.G. Sarafianos; E.N. Kodama Shimane K, Kawaji K, Miyamoto F, Oishi S, Watanabe K, Sakagami Y, Fujii N, Shimura K, Matsuoka M, Kaku M, Sarafianos SG, Kodama EN K. Shimane; K. Kawaji; F. Miyamoto; S. Oishi; K. Watanabe; Y. Sakagami; N. Fujii; K. Shimura; M. Matsuoka; M. Kaku; S.G. Sarafianos; E.N. Kodama HIV-1 resistance mechanism to an electrostatically constrained peptide fusion inhibitor that is active against t-20-resistant strains HIV-1 resistance mechanism to an electrostatically constrained peptide fusion inhibitor that is active against T-20-resistant strains. HIV-1 resistance mechanism to an electrostatically constrained peptide fusion inhibitor that is active against t-20-resistant strains Antimicrobial Agents and Chemotherapy, 57, 8, 4035-4038 Antimicrobial agents and chemotherapy, 57, 8, 4035-4038 Antimicrobial Agents and Chemotherapy, 57, 8, 4035-4038 2013/08 Refereed English Disclose to all
T. Mizuhara; S. Oishi; H. Ohno; K. Shimura; M. Matsuoka; N. Fujii Mizuhara T, Oishi S, Ohno H, Shimura K, Matsuoka M, Fujii N T. Mizuhara; S. Oishi; H. Ohno; K. Shimura; M. Matsuoka; N. Fujii Design and synthesis of biotin- or alkyne-conjugated photoaffinity probes for studying the target molecules of PD 404182 Design and synthesis of biotin- or alkyne-conjugated photoaffinity probes for studying the target molecules of PD 404182. Design and synthesis of biotin- or alkyne-conjugated photoaffinity probes for studying the target molecules of PD 404182 Bioorganic and Medicinal Chemistry, 21, 7, 2079-2087 Bioorganic & medicinal chemistry, 21, 7, 2079-2087 Bioorganic and Medicinal Chemistry, 21, 7, 2079-2087 2013/04 Refereed English Disclose to all
H. Togami; K. Shimura; M. Okamoto; R. Yoshikawa; T. Miyazawa; M. Matsuoka Togami H, Shimura K, Okamoto M, Yoshikawa R, Miyazawa T, Matsuoka M H. Togami; K. Shimura; M. Okamoto; R. Yoshikawa; T. Miyazawa; M. Matsuoka Comprehensive in vitro analysis of simian retrovirus type 4 susceptibility to antiretroviral agents Comprehensive in vitro analysis of simian retrovirus type 4 susceptibility to antiretroviral agents. Comprehensive in vitro analysis of simian retrovirus type 4 susceptibility to antiretroviral agents Journal of Virology, 87, 8, 4322-4329 Journal of virology, 87, 8, 4322-4329 Journal of Virology, 87, 8, 4322-4329 2013/04 Refereed English Disclose to all
K. Izumi; K. Kawaji; F. Miyamoto; K. Shimane; K. Shimura; Y. Sakagami; T. Hattori; K. Watanabe; S. Oishi; N. Fujii; M. Matsuoka; M. Kaku; S.G. Sarafianos; E.N. Kodama Izumi K, Kawaji K, Miyamoto F, Shimane K, Shimura K, Sakagami Y, Hattori T, Watanabe K, Oishi S, Fujii N, Matsuoka M, Kaku M, Sarafianos SG, Kodama EN K. Izumi; K. Kawaji; F. Miyamoto; K. Shimane; K. Shimura; Y. Sakagami; T. Hattori; K. Watanabe; S. Oishi; N. Fujii; M. Matsuoka; M. Kaku; S.G. Sarafianos; E.N. Kodama Mechanism of resistance to S138A substituted enfuvirtide and its application to peptide design Mechanism of resistance to S138A substituted enfuvirtide and its application to peptide design. Mechanism of resistance to S138A substituted enfuvirtide and its application to peptide design International Journal of Biochemistry and Cell Biology, 45, 4, 908-915 The international journal of biochemistry & cell biology, 45, 4, 908-915 International Journal of Biochemistry and Cell Biology, 45, 4, 908-915 2013/04 Refereed English Disclose to all
Togami H, Shimura K, Okamoto M, Yoshikawa R, Miyazawa T, Matsuoka M. Togami H, Shimura K, Okamoto M, Yoshikawa R, Miyazawa T, Matsuoka M. Togami H, Shimura K, Okamoto M, Yoshikawa R, Miyazawa T, Matsuoka M. Comprehensive In Vitro Analysis of Simian Retrovirus Type 4 Susceptibility to Antiretroviral Agents Comprehensive In Vitro Analysis of Simian Retrovirus Type 4 Susceptibility to Antiretroviral Agents Comprehensive In Vitro Analysis of Simian Retrovirus Type 4 Susceptibility to Antiretroviral Agents Journal of Virology, 87, 8, 4322-4329 Journal of Virology, 87, 8, 4322-4329 Journal of Virology, 87, 8, 4322-4329 2013 Refereed Disclose to all
Mizuhara T, Oishi S, Ohno H, Shimura K, Matsuoka M, Fujii N. Mizuhara T, Oishi S, Ohno H, Shimura K, Matsuoka M, Fujii N. Mizuhara T, Oishi S, Ohno H, Shimura K, Matsuoka M, Fujii N. Design and synthesis of biotin- or alkyne-conjugated photoaffinity probes for studying the target molecules of PD 404182 Design and synthesis of biotin- or alkyne-conjugated photoaffinity probes for studying the target molecules of PD 404182 Design and synthesis of biotin- or alkyne-conjugated photoaffinity probes for studying the target molecules of PD 404182 Bioorganic and Medicinal Chemistry, 21, 7, 2079-2087 Bioorganic and Medicinal Chemistry, 21, 7, 2079-2087 Bioorganic and Medicinal Chemistry, 21, 7, 2079-2087 2013 Refereed Disclose to all
Shimane K, Kawaji K, Miyamoto F, Oishi S, Watanabe K, Sakagami Y, Fujii N, Shimura K, Matsuoka M, Kaku M, et al. Shimane K, Kawaji K, Miyamoto F, Oishi S, Watanabe K, Sakagami Y, Fujii N, Shimura K, Matsuoka M, Kaku M, et al. Shimane K, Kawaji K, Miyamoto F, Oishi S, Watanabe K, Sakagami Y, Fujii N, Shimura K, Matsuoka M, Kaku M, et al. HIV-1 Resistance Mechanism to an Electrostatically Constrained Peptide Fusion Inhibitor That Is Active against T-20-Resistant Strains HIV-1 Resistance Mechanism to an Electrostatically Constrained Peptide Fusion Inhibitor That Is Active against T-20-Resistant Strains HIV-1 Resistance Mechanism to an Electrostatically Constrained Peptide Fusion Inhibitor That Is Active against T-20-Resistant Strains Antimicrobial Agents and Chemotherapy, 57, 8, 4035-4038 Antimicrobial Agents and Chemotherapy, 57, 8, 4035-4038 Antimicrobial Agents and Chemotherapy, 57, 8, 4035-4038 2013 Refereed Disclose to all
Izumi Kazuki, Kawaji Kumi, Miyamoto Fusasko, Shimane Kazuki, Shimura Kazuya, Sakagami Yasuko, Hattori Toshio, Watanabe Kentaro, Oishi Shinya, Fujii Nobutaka, et al. Izumi Kazuki, Kawaji Kumi, Miyamoto Fusasko, Shimane Kazuki, Shimura Kazuya, Sakagami Yasuko, Hattori Toshio, Watanabe Kentaro, Oishi Shinya, Fujii Nobutaka, et al. Izumi Kazuki, Kawaji Kumi, Miyamoto Fusasko, Shimane Kazuki, Shimura Kazuya, Sakagami Yasuko, Hattori Toshio, Watanabe Kentaro, Oishi Shinya, Fujii Nobutaka, et al. Mechanism of resistance to S138A substituted enfuvirtide and its application to peptide design Mechanism of resistance to S138A substituted enfuvirtide and its application to peptide design Mechanism of resistance to S138A substituted enfuvirtide and its application to peptide design The International Journal of Biochemistry & Cell Biology, 45, 4, 908-915 The International Journal of Biochemistry & Cell Biology, 45, 4, 908-915 The International Journal of Biochemistry & Cell Biology, 45, 4, 908-915 2013 Refereed Disclose to all
Mizuhara Tsukasa, Kato Takayuki, Hirai Atsushi, Kurihara Hideki, Shimada Yasuhiro, Taniguchi Masahiko, Maeta Hideki, Togami Hiroaki, Shimura Kazuya, Matsuoka Masao, et al. Mizuhara Tsukasa, Kato Takayuki, Hirai Atsushi, Kurihara Hideki, Shimada Yasuhiro, Taniguchi Masahiko, Maeta Hideki, Togami Hiroaki, Shimura Kazuya, Matsuoka Masao, et al. Mizuhara Tsukasa, Kato Takayuki, Hirai Atsushi, Kurihara Hideki, Shimada Yasuhiro, Taniguchi Masahiko, Maeta Hideki, Togami Hiroaki, Shimura Kazuya, Matsuoka Masao, et al. Structure–activity relationship study of phenylpyrazole derivatives as a novel class of anti-HIV agents Structure–activity relationship study of phenylpyrazole derivatives as a novel class of anti-HIV agents Structure–activity relationship study of phenylpyrazole derivatives as a novel class of anti-HIV agents Bioorganic & Medicinal Chemistry Letters, 23, 16, 4557-4561 Bioorganic & Medicinal Chemistry Letters, 23, 16, 4557-4561 Bioorganic & Medicinal Chemistry Letters, 23, 16, 4557-4561 2013 Refereed Disclose to all
T. Mizuhara; S. Oishi; H. Ohno; K. Shimura; M. Matsuoka; N. Fujii Mizuhara T, Oishi S, Ohno H, Shimura K, Matsuoka M, Fujii N T. Mizuhara; S. Oishi; H. Ohno; K. Shimura; M. Matsuoka; N. Fujii Structure-activity relationship study of pyrimido[1,2-c][1,3]benzothiazin- 6-imine derivatives for potent anti-HIV agents Structure-activity relationship study of pyrimido[1,2-c][1,3]benzothiazin-6-imine derivatives for potent anti-HIV agents. Structure-activity relationship study of pyrimido[1,2-c][1,3]benzothiazin- 6-imine derivatives for potent anti-HIV agents Bioorganic and Medicinal Chemistry, 20, 21, 6434-6441 Bioorganic & medicinal chemistry, 20, 21, 6434-6441 Bioorganic and Medicinal Chemistry, 20, 21, 6434-6441 2012/11 Refereed English Disclose to all
G. Tanaka; I. Nakase; Y. Fukuda; R. Masuda; S. Oishi; K. Shimura; Y. Kawaguchi; T. Takatani-Nakase; Ü. Langel; A. Gräslund; K. Okawa; M. Matsuoka; N. Fujii; Y. Hatanaka; S. Futaki Tanaka G, Nakase I, Fukuda Y, Masuda R, Oishi S, Shimura K, Kawaguchi Y, Takatani-Nakase T, Langel U, Gräslund A, Okawa K, Matsuoka M, Fujii N, Hatanaka Y, Futaki S G. Tanaka; I. Nakase; Y. Fukuda; R. Masuda; S. Oishi; K. Shimura; Y. Kawaguchi; T. Takatani-Nakase; Ü. Langel; A. Gräslund; K. Okawa; M. Matsuoka; N. Fujii; Y. Hatanaka; S. Futaki CXCR4 stimulates macropinocytosis: Implications for cellular uptake of arginine-rich cell-penetrating peptides and HIV CXCR4 stimulates macropinocytosis: implications for cellular uptake of arginine-rich cell-penetrating peptides and HIV. CXCR4 stimulates macropinocytosis: Implications for cellular uptake of arginine-rich cell-penetrating peptides and HIV Chemistry and Biology, 19, 11, 1437-1446 Chemistry & biology, 19, 11, 1437-1446 Chemistry and Biology, 19, 11, 1437-1446 2012/11 Refereed English Disclose to all
T. Mizuhara; S. Oishi; H. Ohno; K. Shimura; M. Matsuoka; N. Fujii Mizuhara T, Oishi S, Ohno H, Shimura K, Matsuoka M, Fujii N T. Mizuhara; S. Oishi; H. Ohno; K. Shimura; M. Matsuoka; N. Fujii Concise synthesis and anti-HIV activity of pyrimido[1,2-c][1,3] benzothiazin-6-imines and related tricyclic heterocycles Concise synthesis and anti-HIV activity of pyrimido[1,2-c][1,3]benzothiazin-6-imines and related tricyclic heterocycles. Concise synthesis and anti-HIV activity of pyrimido[1,2-c][1,3] benzothiazin-6-imines and related tricyclic heterocycles Organic and Biomolecular Chemistry, 10, 33, 6792-6802 Organic & biomolecular chemistry, 10, 33, 6792-6802 Organic and Biomolecular Chemistry, 10, 33, 6792-6802 2012/09 Refereed English Disclose to all
志村和也, 松岡雅雄 志村和也, 松岡雅雄 HIV膜融合阻害薬の開発と耐性獲得機序の解析 HIV膜融合阻害薬の開発と耐性獲得機序の解析 遺伝子医学MOOK20 ナノバイオ技術と最新創薬応用研究, 84-88 遺伝子医学MOOK20 ナノバイオ技術と最新創薬応用研究, 84-88 , 84-88 2012 Japanese Disclose to all
Tanaka G, Nakase I, Fukuda Y, Masuda R, Oishi S, Shimura K, Kawaguchi Y, Takatani-Nakase T, Langel Ü, Gräslund A, Okawa K, Matsuoka M, Fujii N, Hatanaka Y, Futaki S. Tanaka G, Nakase I, Fukuda Y, Masuda R, Oishi S, Shimura K, Kawaguchi Y, Takatani-Nakase T, Langel Ü, Gräslund A, Okawa K, Matsuoka M, Fujii N, Hatanaka Y, Futaki S. Tanaka G, Nakase I, Fukuda Y, Masuda R, Oishi S, Shimura K, Kawaguchi Y, Takatani-Nakase T, Langel Ü, Gräslund A, Okawa K, Matsuoka M, Fujii N, Hatanaka Y, Futaki S. CXCR4 stimulates macropinocytosis: Implications for cellular uptake of arginine-rich cell-penetrating peptides and HIV CXCR4 stimulates macropinocytosis: Implications for cellular uptake of arginine-rich cell-penetrating peptides and HIV CXCR4 stimulates macropinocytosis: Implications for cellular uptake of arginine-rich cell-penetrating peptides and HIV Chemistry and Biology, 19, 11, 1437-1446 Chemistry and Biology, 19, 11, 1437-1446 Chemistry and Biology, 19, 11, 1437-1446 2012 Refereed Disclose to all
Mizuhara Tsukasa, Oishi Shinya, Ohno Hiroaki, Shimura Kazuya, Matsuoka Masao, Fujii Nobutaka Mizuhara Tsukasa, Oishi Shinya, Ohno Hiroaki, Shimura Kazuya, Matsuoka Masao, Fujii Nobutaka Mizuhara Tsukasa, Oishi Shinya, Ohno Hiroaki, Shimura Kazuya, Matsuoka Masao, Fujii Nobutaka Concise synthesis and anti-HIV activity of pyrimido[1,2-c][1,3]benzothiazin-6-imines and related tricyclic heterocycles Concise synthesis and anti-HIV activity of pyrimido[1,2-c][1,3]benzothiazin-6-imines and related tricyclic heterocycles Concise synthesis and anti-HIV activity of pyrimido[1,2-c][1,3]benzothiazin-6-imines and related tricyclic heterocycles Organic & Biomolecular Chemistry, 10, 33, 6792 Organic & Biomolecular Chemistry, 10, 33, 6792 Organic & Biomolecular Chemistry, 10, 33, 6792 2012 Refereed Disclose to all
Mizuhara Tsukasa, Oishi Shinya, Ohno Hiroaki, Shimura Kazuya, Matsuoka Masao, Fujii Nobutaka Mizuhara Tsukasa, Oishi Shinya, Ohno Hiroaki, Shimura Kazuya, Matsuoka Masao, Fujii Nobutaka Mizuhara Tsukasa, Oishi Shinya, Ohno Hiroaki, Shimura Kazuya, Matsuoka Masao, Fujii Nobutaka Structure–activity relationship study of pyrimido[1,2-c][1,3]benzothiazin-6-imine derivatives for potent anti-HIV agents Structure–activity relationship study of pyrimido[1,2-c][1,3]benzothiazin-6-imine derivatives for potent anti-HIV agents Structure–activity relationship study of pyrimido[1,2-c][1,3]benzothiazin-6-imine derivatives for potent anti-HIV agents Bioorganic & Medicinal Chemistry, 20, 21, 6434-6441 Bioorganic & Medicinal Chemistry, 20, 21, 6434-6441 Bioorganic & Medicinal Chemistry, 20, 21, 6434-6441 2012 Refereed Disclose to all
E. Inokuchi; S. Oishi; T. Kubo; H. Ohno; K. Shimura; M. Matsuoka; N. Fujii Inokuchi E, Oishi S, Kubo T, Ohno H, Shimura K, Matsuoka M, Fujii N E. Inokuchi; S. Oishi; T. Kubo; H. Ohno; K. Shimura; M. Matsuoka; N. Fujii Potent CXCR4 antagonists containing amidine type peptide bond isosteres Potent CXCR4 antagonists containing amidine type Peptide bond isosteres. Potent CXCR4 antagonists containing amidine type peptide bond isosteres ACS Medicinal Chemistry Letters, 2, 6, 477-480 ACS medicinal chemistry letters, 2, 6, 477-480 ACS Medicinal Chemistry Letters, 2, 6, 477-480 2011/06 Refereed English Disclose to all
K. Izumi; S. Nakamura; H. Nakano; K. Shimura; Y. Sakagami; S. Oishi; S. Uchiyama; T. Ohkubo; Y. Kobayashi; N. Fujii; M. Matsuoka; E.N. Kodama Izumi K, Nakamura S, Nakano H, Shimura K, Sakagami Y, Oishi S, Uchiyama S, Ohkubo T, Kobayashi Y, Fujii N, Matsuoka M, Kodama EN K. Izumi; S. Nakamura; H. Nakano; K. Shimura; Y. Sakagami; S. Oishi; S. Uchiyama; T. Ohkubo; Y. Kobayashi; N. Fujii; M. Matsuoka; E.N. Kodama Characterization of HIV-1 resistance to a fusion inhibitor, N36, derived from the gp41 amino-terminal heptad repeat Characterization of HIV-1 resistance to a fusion inhibitor, N36, derived from the gp41 amino-terminal heptad repeat. Characterization of HIV-1 resistance to a fusion inhibitor, N36, derived from the gp41 amino-terminal heptad repeat Antiviral Research, 87, 2, 179-186 Antiviral research, 87, 2, 179-186 Antiviral Research, 87, 2, 179-186 2010/08 Refereed English Disclose to all
Izumi K, Nakamura S, Nakano H, Shimura K, Sakagami Y, Oishi S, Uchiyama S, Ohkubo T, Kobayashi Y, Fujii N, Matsuoka M, Kodama E.N. Izumi K, Nakamura S, Nakano H, Shimura K, Sakagami Y, Oishi S, Uchiyama S, Ohkubo T, Kobayashi Y, Fujii N, Matsuoka M, Kodama E.N. Izumi K, Nakamura S, Nakano H, Shimura K, Sakagami Y, Oishi S, Uchiyama S, Ohkubo T, Kobayashi Y, Fujii N, Matsuoka M, Kodama E.N. Characterization of HIV-1 resistance to a fusion inhibitor, N36, derived from the gp41 amino-terminal heptad repeat Characterization of HIV-1 resistance to a fusion inhibitor, N36, derived from the gp41 amino-terminal heptad repeat Characterization of HIV-1 resistance to a fusion inhibitor, N36, derived from the gp41 amino-terminal heptad repeat Antiviral Research, 87, 2, 179-186 Antiviral Research, 87, 2, 179-186 Antiviral Research, 87, 2, 179-186 2010 Refereed Disclose to all
Shimura K, Nameki D, Kajiwara K, Watanabe K, Sakagami Y, Oishi S, Fujii N, Matsuoka M, Sarafianos S. G, Kodama E. N. Shimura K, Nameki D, Kajiwara K, Watanabe K, Sakagami Y, Oishi S, Fujii N, Matsuoka M, Sarafianos S. G, Kodama E. N. Shimura K, Nameki D, Kajiwara K, Watanabe K, Sakagami Y, Oishi S, Fujii N, Matsuoka M, Sarafianos S. G, Kodama E. N. Resistance Profiles of Novel Electrostatically Constrained HIV-1 Fusion Inhibitors Resistance Profiles of Novel Electrostatically Constrained HIV-1 Fusion Inhibitors Resistance Profiles of Novel Electrostatically Constrained HIV-1 Fusion Inhibitors Journal of Biological Chemistry, 285, 50, 39471-39480 Journal of Biological Chemistry, 285, 50, 39471-39480 Journal of Biological Chemistry, 285, 50, 39471-39480 2010 Refereed Disclose to all
K. Shimura; E.N. Kodama Shimura K, Kodama EN K. Shimura; E.N. Kodama Elvitegravir: A new HIV integrase inhibitor Elvitegravir: a new HIV integrase inhibitor. Elvitegravir: A new HIV integrase inhibitor Antiviral Chemistry and Chemotherapy, 20, 2, 79-85 Antiviral chemistry & chemotherapy, 20, 2, 79-85 Antiviral Chemistry and Chemotherapy, 20, 2, 79-85 2009/10 Refereed English Disclose to all
M. Ueno; E.N. Kodama; K. Shimura; Y. Sakurai; K. Kajiwara; Y. Sakagami; S. Oishi; N. Fujii; M. Matsuoka Ueno M, Kodama EN, Shimura K, Sakurai Y, Kajiwara K, Sakagami Y, Oishi S, Fujii N, Matsuoka M M. Ueno; E.N. Kodama; K. Shimura; Y. Sakurai; K. Kajiwara; Y. Sakagami; S. Oishi; N. Fujii; M. Matsuoka Synonymous mutations in stem-loop III of Rev responsive elements enhance HIV-1 replication impaired by primary mutations for resistance to enfuvirtide Synonymous mutations in stem-loop III of Rev responsive elements enhance HIV-1 replication impaired by primary mutations for resistance to enfuvirtide. Synonymous mutations in stem-loop III of Rev responsive elements enhance HIV-1 replication impaired by primary mutations for resistance to enfuvirtide Antiviral Research, 82, 1, 67-72 Antiviral research, 82, 1, 67-72 Antiviral Research, 82, 1, 67-72 2009/04 Refereed English Disclose to all
K. Izumi; E. Kodama; K. Shimura; Y. Sakagami; K. Watanabe; S. Ito; T. Watabe; Y. Terakawa; H. Nishikawa; S.G. Sarafianos; K. Kitaura; S. Oishi; N. Fujii; M. Matsuoka Izumi K, Kodama E, Shimura K, Sakagami Y, Watanabe K, Ito S, Watabe T, Terakawa Y, Nishikawa H, Sarafianos SG, Kitaura K, Oishi S, Fujii N, Matsuoka M K. Izumi; E. Kodama; K. Shimura; Y. Sakagami; K. Watanabe; S. Ito; T. Watabe; Y. Terakawa; H. Nishikawa; S.G. Sarafianos; K. Kitaura; S. Oishi; N. Fujii; M. Matsuoka Design of peptide-based inhibitors for human immunodeficiency virus type 1 strains resistant to T-20 Design of peptide-based inhibitors for human immunodeficiency virus type 1 strains resistant to T-20. Design of peptide-based inhibitors for human immunodeficiency virus type 1 strains resistant to T-20 Journal of Biological Chemistry, 284, 8, 4914-4920 The Journal of biological chemistry, 284, 8, 4914-4920 Journal of Biological Chemistry, 284, 8, 4914-4920 2009/02 Refereed English Disclose to all
Shimura Kazuya, Kodama Eiichi N Shimura Kazuya, Kodama Eiichi N Shimura Kazuya, Kodama Eiichi N Elvitegravir: a new HIV integrase inhibitor Elvitegravir: a new HIV integrase inhibitor Elvitegravir: a new HIV integrase inhibitor Antiviral Chemistry & Chemotherapy, 20, 2, 79-85 Antiviral Chemistry & Chemotherapy, 20, 2, 79-85 Antiviral Chemistry & Chemotherapy, 20, 2, 79-85 2009 Refereed Disclose to all
Ueno Mariko, Kodama Eiichi N, Shimura Kazuya, Sakurai Yasuteru, Kajiwara Keiko, Sakagami Yasuko, Oishi Shinya, Fujii Nobutaka, Matsuoka Masao Ueno Mariko, Kodama Eiichi N, Shimura Kazuya, Sakurai Yasuteru, Kajiwara Keiko, Sakagami Yasuko, Oishi Shinya, Fujii Nobutaka, Matsuoka Masao Ueno Mariko, Kodama Eiichi N, Shimura Kazuya, Sakurai Yasuteru, Kajiwara Keiko, Sakagami Yasuko, Oishi Shinya, Fujii Nobutaka, Matsuoka Masao Synonymous mutations in stem-loop III of Rev responsive elements enhance HIV-1 replication impaired by primary mutations for resistance to enfuvirtide Synonymous mutations in stem-loop III of Rev responsive elements enhance HIV-1 replication impaired by primary mutations for resistance to enfuvirtide Synonymous mutations in stem-loop III of Rev responsive elements enhance HIV-1 replication impaired by primary mutations for resistance to enfuvirtide Antiviral Research, 82, 1, 67-72 Antiviral Research, 82, 1, 67-72 Antiviral Research, 82, 1, 67-72 2009 Refereed Disclose to all
K. Shimura; E. Kodama; Y. Sakagami; Y. Matsuzaki; W. Watanabe; K. Yamataka; Y. Watanabe; Y. Ohata; S. Doi; M. Sato; M. Kano; S. Ikeda; M. Matsuoka Shimura K, Kodama E, Sakagami Y, Matsuzaki Y, Watanabe W, Yamataka K, Watanabe Y, Ohata Y, Doi S, Sato M, Kano M, Ikeda S, Matsuoka M K. Shimura; E. Kodama; Y. Sakagami; Y. Matsuzaki; W. Watanabe; K. Yamataka; Y. Watanabe; Y. Ohata; S. Doi; M. Sato; M. Kano; S. Ikeda; M. Matsuoka Broad antiretroviral activity and resistance profile of the novel human immunodeficiency virus integrase inhibitor elvitegravir (JTK-303/GS-9137) Broad antiretroviral activity and resistance profile of the novel human immunodeficiency virus integrase inhibitor elvitegravir (JTK-303/GS-9137). Broad antiretroviral activity and resistance profile of the novel human immunodeficiency virus integrase inhibitor elvitegravir (JTK-303/GS-9137) Journal of Virology, 82, 2, 764-774 Journal of virology, 82, 2, 764-774 Journal of Virology, 82, 2, 764-774 2008/01 Refereed English Disclose to all
Shimura K, Kodama E, Sakagami Y, Matsuzaki Y, Watanabe W, Yamataka K, Watanabe Y, Ohata Y, Doi S, Sato M, et al. Shimura K, Kodama E, Sakagami Y, Matsuzaki Y, Watanabe W, Yamataka K, Watanabe Y, Ohata Y, Doi S, Sato M, et al. Shimura K, Kodama E, Sakagami Y, Matsuzaki Y, Watanabe W, Yamataka K, Watanabe Y, Ohata Y, Doi S, Sato M, et al. Broad Antiretroviral Activity and Resistance Profile of the Novel Human Immunodeficiency Virus Integrase Inhibitor Elvitegravir (JTK-303/GS-9137) Broad Antiretroviral Activity and Resistance Profile of the Novel Human Immunodeficiency Virus Integrase Inhibitor Elvitegravir (JTK-303/GS-9137) Broad Antiretroviral Activity and Resistance Profile of the Novel Human Immunodeficiency Virus Integrase Inhibitor Elvitegravir (JTK-303/GS-9137) Journal of Virology, 82, 2, 764-774 Journal of Virology, 82, 2, 764-774 Journal of Virology, 82, 2, 764-774 2008 Refereed Disclose to all
Izumi K, Kodama E, Shimura K, Sakagami Y, Watanabe K, Ito S, Watabe T, Terakawa Y, Nishikawa H, Sarafianos S. G, et al. Izumi K, Kodama E, Shimura K, Sakagami Y, Watanabe K, Ito S, Watabe T, Terakawa Y, Nishikawa H, Sarafianos S. G, et al. Izumi K, Kodama E, Shimura K, Sakagami Y, Watanabe K, Ito S, Watabe T, Terakawa Y, Nishikawa H, Sarafianos S. G, et al. Design of Peptide-based Inhibitors for Human Immunodeficiency Virus Type 1 Strains Resistant to T-20 Design of Peptide-based Inhibitors for Human Immunodeficiency Virus Type 1 Strains Resistant to T-20 Design of Peptide-based Inhibitors for Human Immunodeficiency Virus Type 1 Strains Resistant to T-20 Journal of Biological Chemistry, 284, 8, 4914-4920 Journal of Biological Chemistry, 284, 8, 4914-4920 Journal of Biological Chemistry, 284, 8, 4914-4920 2008 Refereed Disclose to all
K. Shimura; E. Kodama Shimura K, Kodama E. K. Shimura; E. Kodama Elvitegravir: An emerging HIV integrase inhibitor Elvitegravir: An emerging HIV integrase inhibitor Elvitegravir: An emerging HIV integrase inhibitor Future HIV Therapy, 2, 5, 411-418 Future HIV Therapy, 2, 5, 411-418 Future HIV Therapy, 2, 5, 411-418 2008 Refereed English Disclose to all
K. Shimura; D. Nameki; K. Kajiwara; K. Watanabe; Y. Sakagami; S. Oishi; N. Fujii; M. Matsuoka; S.G. Sarafianos; E.N. Kodama K. Shimura; D. Nameki; K. Kajiwara; K. Watanabe; Y. Sakagami; S. Oishi; N. Fujii; M. Matsuoka; S.G. Sarafianos; E.N. Kodama Resistance profiles of novel electrostatically constrained HIV-1 fusion inhibitors Resistance profiles of novel electrostatically constrained HIV-1 fusion inhibitors Journal of Biological Chemistry, 285, 50, 39471-39480 , 285, 50, 39471-39480 Journal of Biological Chemistry, 285, 50, 39471-39480 2010 Refereed English Disclose to all

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Author Author(Japanese) Author(English) Title Title(Japanese) Title(English) Bibliography Bibliography(Japanese) Bibliography(English) Publication date Refereed paper Language Publishing type Disclose
志村和也、松岡雅雄 志村和也、松岡雅雄 HIV感染経路が抗ウイルス薬感受性とウイルス産生に与える影響 HIV感染経路が抗ウイルス薬感受性とウイルス産生に与える影響 第28回日本エイズ学会学術集会 第28回日本エイズ学会学術集会 2014 Japanese Disclose to all
志村和也、大石真也、藤井信孝、松岡雅雄 志村和也、大石真也、藤井信孝、松岡雅雄 抗ウイルス薬感受性に対するHIV感染経路の影響 抗ウイルス薬感受性に対するHIV感染経路の影響 第27回日本エイズ学会学術集会 第27回日本エイズ学会学術集会 2013 Disclose to all
志村和也、水原司、大石真也、藤井信孝、松岡雅雄 志村和也、水原司、大石真也、藤井信孝、松岡雅雄 広範なスペクトルを有する新規抗HIV薬の同定とその開発 広範なスペクトルを有する新規抗HIV薬の同定とその開発 第26回日本エイズ学会学術集会 第26回日本エイズ学会学術集会 2012 Disclose to all
戸上博昭、志村和也、宮沢孝幸、松岡雅雄 戸上博昭、志村和也、宮沢孝幸、松岡雅雄 ニホンザルより検出されたSRV-4に対する抗HIV薬の効果 ニホンザルより検出されたSRV-4に対する抗HIV薬の効果 第60回日本ウイルス学会学術集会 第60回日本ウイルス学会学術集会 2012 Japanese Disclose to all
志村和也、大石真也、藤井信孝、松岡雅雄 志村和也、大石真也、藤井信孝、松岡雅雄 HIV-1膜融合阻害剤に対する新規耐性メカニズムの解析 HIV-1膜融合阻害剤に対する新規耐性メカニズムの解析 第25回日本エイズ学会学術集会 第25回日本エイズ学会学術集会 2011 Japanese Disclose to all
Kazuya Shimura, Eiichi Kodama, Daisuke Namek, Yasuko Sakagami, Shinya Oishi, Nobutaka Fujii, Masao Matsuoka Kazuya Shimura, Eiichi Kodama, Daisuke Namek, Yasuko Sakagami, Shinya Oishi, Nobutaka Fujii, Masao Matsuoka Resistant Profile of the Electrostatically Constrained Next-generation HIV-1 Fusion Inhibitors Resistant Profile of the Electrostatically Constrained Next-generation HIV-1 Fusion Inhibitors Resistant Profile of the Electrostatically Constrained Next-generation HIV-1 Fusion Inhibitors 16th Conference on Retroviruses and Opportunistic Infections 16th Conference on Retroviruses and Opportunistic Infections 16th Conference on Retroviruses and Opportunistic Infections 2009 Disclose to all
志村和也、児玉栄一、阪上泰子、松崎裕児、渡辺渡、山高一修、佐藤元秀、加納光記、池田了、松岡雅雄 志村和也、児玉栄一、阪上泰子、松崎裕児、渡辺渡、山高一修、佐藤元秀、加納光記、池田了、松岡雅雄 HIVインテグレース阻害剤Elvitegravir (JTK-303/GS-9137) の抗ウイルス活性および耐性機序の解析 HIVインテグレース阻害剤Elvitegravir (JTK-303/GS-9137) の抗ウイルス活性および耐性機序の解析 第17回抗ウイルス療法研究会 第17回抗ウイルス療法研究会 2007 Japanese Disclose to all
志村和也、児玉栄一、池田了、松岡雅雄 志村和也、児玉栄一、池田了、松岡雅雄 インテグレース阻害剤に対する耐性HIVの誘導とその複製能の比較 インテグレース阻害剤に対する耐性HIVの誘導とその複製能の比較 第21回日本エイズ学会学術集会 第21回日本エイズ学会学術集会 2007 Japanese Disclose to all
泉和樹、西川裕輝、伊藤紗織、児玉栄一、志村和也、大石真也、藤井信孝、松岡雅雄 泉和樹、西川裕輝、伊藤紗織、児玉栄一、志村和也、大石真也、藤井信孝、松岡雅雄 T-20耐性HIV-1に対して有効な融合阻害薬の開発 T-20耐性HIV-1に対して有効な融合阻害薬の開発 第17回抗ウイルス療法研究会 第17回抗ウイルス療法研究会 2007 Japanese Disclose to all
泉和樹、児玉栄一、志村和也、大石真也、藤井信孝、松岡雅雄 泉和樹、児玉栄一、志村和也、大石真也、藤井信孝、松岡雅雄 T-20耐性変異を利用した融合阻害薬の開発 T-20耐性変異を利用した融合阻害薬の開発 第21回日本エイズ学会学術集会 第21回日本エイズ学会学術集会 2007 Japanese Disclose to all
志村和也、児玉栄一、池田了、松岡雅雄 志村和也、児玉栄一、池田了、松岡雅雄 新規HIVインテグレース阻害剤JTK-303/GS-9137の抗HIV 活性および耐性機序の解析 新規HIVインテグレース阻害剤JTK-303/GS-9137の抗HIV 活性および耐性機序の解析 第20回日本エイズ学会学術集会 第20回日本エイズ学会学術集会 2006 Japanese Disclose to all
Kodama E, Shimura K, Sakagami Y, Matsuzaki Y, Watanabe W, Yamataka K, Sato M, Kano M, Ikeda S, Matsuoka M. Kodama E, Shimura K, Sakagami Y, Matsuzaki Y, Watanabe W, Yamataka K, Sato M, Kano M, Ikeda S, Matsuoka M. In Vitro Antiviral Activity and Resistance Profile of a Novel HIV Integrase Inhibitor JTK-303/GS-9137 In Vitro Antiviral Activity and Resistance Profile of a Novel HIV Integrase Inhibitor JTK-303/GS-9137 In Vitro Antiviral Activity and Resistance Profile of a Novel HIV Integrase Inhibitor JTK-303/GS-9137 46th Interscience Conference on Antimicrobial Agents and Chemotherapy, San Francisco, CA, Sep 27-30, 2006. 46th Interscience Conference on Antimicrobial Agents and Chemotherapy, San Francisco, CA, Sep 27-30, 2006. 2006 English Disclose to all
上野真理子、梶原慶子、志村和也、児玉栄一、松岡雅雄 上野真理子、梶原慶子、志村和也、児玉栄一、松岡雅雄 融合阻害剤 T-20(Fuzeon)に対する耐性HIVの解析 融合阻害剤 T-20(Fuzeon)に対する耐性HIVの解析 第19回日本エイズ学会学術集会 第19回日本エイズ学会学術集会 2005 Japanese Disclose to all

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External funds: competitive funds and Grants-in-Aid for Scientific Research (Kakenhi)
Type Position Title(Japanese) Title(English) Period
政策創薬総合研究経費 Assignment 新規標的に対する小分子化合物を基盤とした抗HIV化学療法剤の開発 2012-2012
研究活動スタート支援 Representative 新たなHIV融合阻害薬耐性化メカニズムの解明と臨床的意義の検討 2011-2011
若手研究(B) Representative ヒト免疫不全ウイルスの細胞間感染による薬剤感受性・ウイルス複製動態への影響 2012-2013
若手研究(B) Representative エイズウイルスの経路依存的な新規細胞侵入機構と薬剤耐性との関連性 2015-2016
若手研究(B) Representative エイズウイルスの経路依存的な新規細胞侵入機構と薬剤耐性との関連性 (平成27年度分) 2015/04/01-2016/03/31
若手研究(B) Representative エイズウイルスの経路依存的な新規細胞侵入機構と薬剤耐性との関連性 (平成28年度分) 2016/04/01-2017/03/31
基盤研究(C) Representative HIV潜伏感染モデル細胞における再活性化動態に関する研究 (平成29年度分) 2017/04/01-2018/03/31
若手研究(B) Representative エイズウイルスの経路依存的な新規細胞侵入機構と薬剤耐性との関連性 (平成29年度分) 2017/04/01-2018/03/31
基盤研究(C) Representative HIV潜伏感染モデル細胞における再活性化動態に関する研究 (平成30年度分) 2018/04/01-2019/03/31
Teaching subject(s)
Name(Japanese) Name(English) Term Department Period
生命科学研究の第一線に立つII The Front Line of Life Science Research II 前期 全学共通科目 2013/04-2014/03
生命科学研究の第一線に立つII The Front Line of Life Science Research II 前期 全学共通科目 2014/04-2015/03
生命科学研究の第一線に立つII The Front Line of Life Science Research II 前期 全学共通科目 2015/04-2016/03
School management (title, position)
Title Period
衛生管理者 2017/04/01-2019/03/31
Faculty management (title, position)
Title Period
図書委員会 委員 2014/04/01-2015/03/31
化学物質管理委員会 委員 2013/04/01-2017/03/31
病原体安全管理委員会 委員 2016/10/01-2019/03/31
化学物質管理委員会 委員 2016/10/01-
安全衛生委員会 委員 2016/10/01-2019/03/31